Drug name	Is cardiotoxic	Drug class	Brand name	Approval data	Human targets
afatinib	No	Kinase inhibitor	Gilotrif	7/12/2013	EGFR;ERBB2;ERBB4
amiodarone	No	Antiarrhythmic	Cordarone	12/24/1985	ADRB1;ADRB2;ADRB3;CACNA1C;CACNA1D;CACNA1F;CACNA1I;CACNA1S;CACNB1;CACNB2;CACNB3;CACNB4;KCNH2;KCNH6;KCNH7;PPARA;PPARG;PPARGC1B
axitinib	No	Kinase inhibitor	Inlyta	1/27/2012	FLT1;FLT4;KDR
azacitidine	No	Antineoplastic	Vidaza	5/19/2004	DNA;DNMT1;RNA
bevacizumab	Yes	Monoclonal antibody	Avastin	2/26/2004	C1QA;C1QB;C1QC;FCGR1A;FCGR2A;FCGR2B;FCGR2C;FCGR3A;VEGFA
bortezomib	Yes	Antiproteasome	Velcade	5/13/2003	PSMB1;PSMB5
bosutinib	No	Kinase inhibitor	Bosulif	9/4/2012	ABL1;BCR;CAMK2G;CDK2;HCK;LYN;MAP2K1;MAP2K2;MAP3K2;SRC
cabozantinib	No	Kinase inhibitor	Cometriq	4/26/2016	KDR;MET;RET
carfilzomib	Yes	Antiproteasome	Kyprolis	7/20/2012	PSMB1;PSMB10;PSMB2;PSMB5;PSMB8;PSMB9
ceritinib	No	Kinase inhibitor	Zykadia	4/29/2014	ALK
crizotinib	No	Kinase inhibitor	Xalkori	8/26/2011	ALK;MET
cetuximab	No	Monoclonal antibody	Erbitux	11/7/2011	C1QA;C1QB;C1QC;EGFR;FCGR1A;FCGR2A;FCGR3A;FCGR3B
cyclosporine	Yes	Immunosuppressant	Restasis	1/13/2000	
dabrafenib	Yes	Kinase inhibitor	Tafinlar	5/29/2013	BRAF;LIMK1;NEK11;RAF1;SIK1
dasatinib	No	Kinase inhibitor	Sprycel	6/28/2006	ABL1;ABL2;BCR;BTK;CSK;EPHA2;EPHA5;EPHB4;FGR;FRK;FYN;HSPA8;KIT;LCK;LYN;MAPK14;NR4A3;PDGFRB;PPAT;SRC;STAT5B;YES1;ZAK
daunorubicin	Yes	Anthracycline	Cerubidine	8/3/2017	DNA;TOP2A;TOP2B
decitabine	No	Antineoplastic	Dacogen	2/2/2006	DNA;DNMT1;DNMT3A;DNMT3B
delavirdine	No	Antiviral	Rescriptor	5/16/2001	No human drug target proteins in drug bank
diclofenac	No	Anti-inflammatory	Voltaren	10/17/2007	PTGS1;PTGS2
dobutamine	No	Sympathomimetic	Dobutrex	7/23/2002	ADRA1A;ADRA1B;ADRA1D;ADRB1;ADRB2;ESR1
doxorubicin	Yes	Anthracycline	Adriamycin	5/8/2003	DNA;NOLC1;TOP2A
endothelin-1	No	Endogenous vasoconstrictor		No record in FDA	No human drug target proteins in drug bank
epirubicin	Yes	Anthracycline	Ellence	9/15/2006	DNA;TOP2A
erlotinib	No	Kinase inhibitor	Tarceva	11/18/2004	EGFR;NR1I2
estradiol	No	Female sex hormone	Estrace	2/9/2004	BECN1;CHRNA4;ESR1;ESR2;GPER1;MT-ATP6;NR1I2
flecainide	Yes	Antiarrhythmic	Tambocor	10/31/1985	KCNH2;RYR2;SCN4A;SCN5A
gefitinib	No	Kinase inhibitor	Iressa	5/3/2003	EGFR
idarubicin	Yes	Anthracycline	Idamycin	2/17/1997	DNA;TOP2A
insulin-like growth factor 1	No	Hormone		No record in FDA	No human drug target proteins in drug bank
imatinib	No	Kinase inhibitor	Gleevec	5/20/2003	ABL1;BCR;CSF1R;DDR1;KIT;NTRK1;PDGFRA;PDGFRB;RET
isoprenaline	No	Sympathomimetic	Isuprel	1/1/1982	ADRB1;ADRB2;ADRB3;SOD1
lapatinib	Yes	Kinase inhibitor	Tykerb	3/13/2007	EGFR;ERBB2
milrinone	Yes	Vasodilatator	Primacor	5/28/2002	PDE3A
nilotinib	No	Kinase inhibitor	Tasigna	10/29/2007	ABL1;KIT
olmesartan	No	Antihypertensive	Benicar	6/5/2003	AGTR1
pazopanib	Yes	Kinase inhibitor	Votrient	10/19/2009	FGF1;FGFR3;FLT1;FLT4;ITK;KDR;KIT;PDGFRA;PDGFRB;SH2B3
phenylephrine	No	Sympathomimetic	Neofrin	12/20/2012	ADRA1A;ADRA1B;ADRA1D
pioglitazone	No	Antidiabetic	Actos	7/15/1999	MAOB;PPARG
ponatinib	Yes	Kinase inhibitor	Iclusig	12/14/2012	ABL1;BCR;FGFR1;FGFR2;FGFR3;FGFR4;FLT3;KDR;KIT;LCK;LYN;PDGFRA;RET;SRC;TEK
prednisolone	Yes	Glucocorticoid	Cotolone	7/26/2012	NR3C1
regorafenib	No	Kinase inhibitor	Stivarga	9/27/2012	ABL1;BRAF;DDR2;EPHA2;FGFR1;FGFR2;FLT1;FLT4;FRK;KDR;KIT;MAPK11;NTRK1;PDGFRA;PDGFRB;RAF1;RET;TEK
rosiglitazone	No	Antidiabetic	Avandia	5/25/1999	ACSL4;PPARA;PPARD;PPARG;RXRA;RXRB;RXRG
rituximab	No	Monoclonal antibody	Rituxan	11/26/1997	No human drug target proteins in drug bank
ruxolitinib	No	Kinase inhibitor	Jakafi	11/16/2011	JAK1;JAK2;JAK3;TYK2
saxagliptin	No	Antidiabetic	Onglyza	7/31/2009	DPP4
sorafenib	Yes	Kinase inhibitor	Nexavar	12/20/2005	BRAF;FGFR1;FLT1;FLT3;FLT4;KDR;KIT;PDGFRB;RAF1;RET
sunitinib	Yes	Kinase inhibitor	Sutent	1/26/2006	CSF1R;FLT1;FLT3;FLT4;KDR;KIT;PDGFRA;PDGFRB
tnf-alpha		Cytokine			No human drug target proteins in drug bank
tofacitinib	No	Kinase inhibitor	Xeljanz	11/6/2012	JAK1;JAK2;JAK3;TYK2
trametinib	Yes	Kinase inhibitor	Mekinist	5/29/2013	MAP2K1;MAP2K2
trastuzumab	Yes	Monoclonal antibody	Herceptin	9/25/1998	ERBB2
vandetanib	Yes	Kinase inhibitor	Caprelsa	4/6/2011	EGFR;PTK6;RET;TEK;VEGFA
vemurafenib	No	Kinase inhibitor	Zelboraf	8/17/2011	BRAF
verapamil	Yes	Antiarrhythmic	Verelan	11/25/1998	ADRA1A;ADRA1B;ADRA1D;CACNA1A;CACNA1B;CACNA1C;CACNA1G;CACNA1H;KCNH2;KCNJ11;SLC6A4