Drug name Is cardiotoxic Drug class Risk frequency Odds ratio rank (FAERS) Odds ratio (FAERS) Date of approval # of years analysed # all adverse events # cardiotoxic adverse events Lower confidence interval (FAERS) Upper confidence interval (FAERS) trastuzumab Yes Monoclonal_antibody >10% 01 51.29602 9/25/1998 22 30208 545 46.86559 56.14529 doxorubicin Yes Anthracycline >10% 02 41.5502 5/8/2003 17 64976 917 38.62151 44.70097 daunorubicin Yes Anthracycline 03 28.02495 8/3/2017 3 4028 61 21.69462 36.20241 epirubicin Yes Anthracycline >10% 04 23.99009 9/15/2006 14 12527 127 20.08957 28.64792 idarubicin Yes Anthracycline >10% 05 20.47212 2/17/1997 23 4923 40 14.97677 27.98384 flecainide Yes Antiarrhythmic NaN 17.75334 10/31/1985 35 4974 33 12.59096 25.03234 lapatinib Yes Kinase_inhibitor 1-10% 06 13.08875 3/13/2007 13 9316 53 9.974654 17.17507 vandetanib Yes Kinase_inhibitor 1-10% 07 10.17172 4/6/2011 9 856 4 3.806851 27.17834 verapamil Yes Antiarrhythmic NaN 9.927223 11/25/1998 22 10781 43 7.347333 13.413 milrinone Yes Vasodilatator NaN 9.636311 5/28/2002 18 486 2 2.402328 38.65354 carfilzomib Yes Antiproteasome 1-10% 08 8.988023 7/20/2012 8 9043 38 6.524911 12.38094 rituximab No Monoclonal_antibody <1% 09 6.166714 11/26/1997 23 102108 242 5.416574 7.020741 bortezomib Yes Antiproteasome 1-10% 10 6.140896 5/13/2003 17 32672 85 4.953207 7.613373 pazopanib Yes Kinase_inhibitor >10% 11 4.182609 10/19/2009 11 14563 27 2.863683 6.108993 sorafenib Yes Kinase_inhibitor 1-10% 12 4.110372 12/20/2005 15 16918 30 2.8694 5.888046 bevacizumab Yes Monoclonal_antibody 1-10% 13 3.702681 2/26/2004 16 67392 106 3.053204 4.490315 dasatinib No Kinase_inhibitor No risk reported 14 3.514665 6/28/2006 14 13666 21 2.288403 5.398029 trametinib Yes Kinase_inhibitor >10% 15 3.418551 5/29/2013 7 9808 16 2.091099 5.588686 imatinib No Kinase_inhibitor <1% 16 3.244866 5/20/2003 17 42570 59 2.509319 4.19602 vemurafenib No Kinase_inhibitor No risk reported 17 3.195844 8/17/2011 9 7476 11 1.767566 5.778239 sunitinib Yes Kinase_inhibitor >10% 18 3.118081 1/26/2006 14 27940 38 2.265114 4.292245 prednisolone Yes Glucocorticoid NaN 2.498561 7/26/2012 8 45209 53 1.904811 3.277388 ponatinib Yes Kinase_inhibitor 1-10% 19 2.43296 12/14/2012 8 6086 7 1.158552 5.109219 cyclosporine Yes Immunosuppressant NaN 2.1048 1/13/2000 20 45769 40 1.541542 2.873865 dabrafenib Yes Kinase_inhibitor 1-10% 20 2.050532 5/29/2013 7 9174 9 1.065667 3.945587 nilotinib No Kinase_inhibitor No risk reported 21 1.969368 10/29/2007 13 16113 14 1.165067 3.328918 cetuximab No Monoclonal_antibody No risk reported 22 1.93248 11/7/2011 9 12349 11 1.069005 3.493417 azacitidine No Other_chemotherapy_drug NaN 1.82911 5/19/2004 16 12646 10 0.9832123 3.40277 axitinib No Kinase_inhibitor <1% 23 1.762127 1/27/2012 8 5997 5 0.7327321 4.237689 bosutinib No Kinase_inhibitor No risk reported 24 1.751858 9/4/2012 8 2412 2 0.4377087 7.011528 amiodarone No Antiarrhythmic NaN 1.559087 12/24/1985 35 30537 18 0.9812312 2.477246 afatinib No Kinase_inhibitor 25 1.374713 7/12/2013 7 4568 3 0.4429839 4.266148 dobutamine No Sympathomimetic NaN 1.353767 7/23/2002 18 1723 1 0.1905392 9.618419 gefitinib No Kinase_inhibitor 26 1.265209 5/3/2003 17 7329 4 0.4745099 3.373489 ceritinib No Kinase_inhibitor No risk reported 27 1.156491 4/29/2014 6 1807 1 0.1627633 8.217281 cabozantinib No Kinase_inhibitor No risk reported 28 1.127833 4/26/2016 4 6679 4 0.4228635 3.008081 decitabine No Other_chemotherapy_drug NaN 0.948975 2/2/2006 14 2399 1 0.1335859 6.741383 erlotinib No Kinase_inhibitor No risk reported 29 0.8975261 11/18/2004 16 33444 13 0.520673 1.547138 crizotinib No Kinase_inhibitor No risk reported 30 0.6727768 8/26/2011 9 6435 2 0.1681585 2.691679 regorafenib No Kinase_inhibitor No risk reported 31 0.3205124 9/27/2012 8 6582 1 0.04512819 2.276364 pioglitazone No Antidiabetic NaN 0.1350323 7/15/1999 21 17946 1 0.01901522 0.9589013 delavirdine No Antiviral NaN 0 5/16/2001 19 196 0 0 0 diclofenac No Nsaid NaN 0 10/17/2007 13 28848 0 0 0 endothelin-1 No Endogenous_vasoconstrictor NaN 0 No record in FDA 0 0 0 0 0 estradiol No Female_sex_hormone NaN 0 2/9/2004 16 11232 0 0 0 insulin-like growth factor 1 No Hormone NaN 0 No record in FDA 0 0 0 0 0 isoprenaline No Sympathomimetic NaN 0 1/1/1982 38 287 0 0 0 olmesartan No Antihypertensive NaN 0 6/5/2003 17 12391 0 0 0 phenylephrine No Sympathomimetic NaN 0 12/20/2012 8 2101 0 0 0 rosiglitazone No Antidiabetic NaN 0 5/25/1999 21 84471 0 0 0 ruxolitinib No Kinase_inhibitor No risk reported 32 0 11/16/2011 9 22646 0 0 0 saxagliptin No Antidiabetic NaN 0 7/31/2009 11 3061 0 0 0 tofacitinib No Kinase_inhibitor 33 0 11/6/2012 8 34751 0 0 0