Pathway	Up or down	F1 score AUC rank
Citric acid cycle	Up	1
Lysosomal glycoprotein degradation	Up	2
Restriction point	Up	3
Polyol pathway	Down	4
Leptin receptor signaling	Up	5
Myofibril formation	Down	6
Potassium transmembrane transport	Up	7
Adrenergic receptor signaling	Down	8
Water transmembrane transport	Down	9
Thyroid hormone receptor signaling	Up	10
Desaturation of fatty acids	Up	11
Vascular endothelial growth factor receptor signaling	Up	12
Hippo signaling	Down	13
Platelet-derived growth factor receptor signaling	Down	14
Cholesterol-sensitive control of SREBP activation	Up	15
Granulocyte-colony stimulating factor receptor signaling	Up	16
Chloride transmembrane transport	Down	17
Biglycan synthesis	Down	18
Serine and glycine metabolism	Up	19
HIF-1 receptor signaling pathway	Down	20
Thin myofilament organization	Down	21
Cholesterol synthesis	Up	22
Cellular cholesterol uptake and efflux	Down	23
Gap junction organization	Down	24
Transamination pathways	Up	25