predicTox

Datasets

NaN = Not a Number/Not Determined

Drug-induced pathways across all cell lines

Drug Name Drug Class Is Cardiotoxic Up/Down Pathway Enrichment p-value Enrichment rank Pathway F1 score AUC rank Cardiotoxicity Pathway Pathway Genes
verapamil Antiarrhythmic Yes Down Actin filament bundling and crosslinking 0.04714737 22 NaN ACTN2;SYNPO;TAGLN
verapamil Antiarrhythmic Yes Down Actin polymerization 0.042319189 20 NaN ABRA;ACTA1;ENAH;HSPB1
verapamil Antiarrhythmic Yes Up Alternative complement pathway 0.001694401 2 NaN C1S;C3
verapamil Antiarrhythmic Yes Down Antigen presentation via MHC class I molecules 0.037654174 17 NaN HLA-A;HLA-C
verapamil Antiarrhythmic Yes Up Cardiomyocyte repolarization during action potential and hyperpolarization 0.014260416 10 NaN KCNIP2;KCNJ2
verapamil Antiarrhythmic Yes Up Cellular cholesterol uptake and efflux 0.012329314 7 NaN ABCA1;ABCG1
verapamil Antiarrhythmic Yes Down Cholesterol synthesis 0.023724425 13 NaN DHCR24;DHCR7;MSMO1
verapamil Antiarrhythmic Yes Up Classical complement pathway 0.003496783 3.5 NaN C1R;C1S
verapamil Antiarrhythmic Yes Down Collagen fibril organization by fibril-associated bridges 0.013640012 10.5 NaN COL12A1;COL9A2
verapamil Antiarrhythmic Yes Down Connection of muscle sarcomere to plasma membrane 0.003151618 6 NaN DES;ILK;SYNM
verapamil Antiarrhythmic Yes Up Decorin synthesis 0.013232181 8.5 NaN DCN
verapamil Antiarrhythmic Yes Down Epithelial intermediate filament dynamics 0.001541535 5 NaN KRT19;KRT7;KRT8
verapamil Antiarrhythmic Yes Up Extracellular matrix breakdown and membrane shedding by adamalysins 0.003748527 5 NaN ADAMTS14;ADAMTS5;ADAMTS6
verapamil Antiarrhythmic Yes Down Glycolysis and Gluconeogenesis 2.90E-07 2 NaN ALDOA;ENO1;HK2;LDHA;PFKP;PGAM1;PGK1;TPI1
verapamil Antiarrhythmic Yes Up G-protein coupled receptor signaling pathway 0.028275372 12 NaN GRK5;RGS6
verapamil Antiarrhythmic Yes Down Granulocyte macrophage colony-stimulating factor receptor signaling 0.000989092 4 NaN JAK2;JUND
verapamil Antiarrhythmic Yes Down Growth differentiation factor receptor signaling 0.024421416 14 NaN GDF11;GDF2
verapamil Antiarrhythmic Yes Up Hemoglobin and myoglobin synthesis 0.039176997 13.5 NaN MB
verapamil Antiarrhythmic Yes Up Inhibition of amyloid aggregation, amyloid degradation and uptake 0.039176997 13.5 NaN MME
verapamil Antiarrhythmic Yes Down Microtubule crosslinking and bundling 0.013640012 10.5 NaN MAP2;MTCL1
verapamil Antiarrhythmic Yes Down Microtubule polymerization 0.013640012 10.5 NaN MAP4;TUBA1A
verapamil Antiarrhythmic Yes Down Myofibril formation 0.037654174 17 NaN DES;XIRP1
verapamil Antiarrhythmic Yes Down Natriuretic peptide receptor signaling 0.013640012 10.5 NaN NPPA;NPPB
verapamil Antiarrhythmic Yes Up Platelet-derived growth factor receptor signaling 0.008845574 6 NaN PDGFD;PDGFRA
verapamil Antiarrhythmic Yes Down Potassium transmembrane transport 0.038420172 19 NaN ATP1A2;ATP1A3;FXYD1
verapamil Antiarrhythmic Yes Down Progesterone receptor signaling 0.03149259 15 NaN PGR
verapamil Antiarrhythmic Yes Down Restriction point 0.037654174 17 NaN CCND2;CDKN1A
verapamil Antiarrhythmic Yes Up Roundabout signaling 0.003496783 3.5 NaN ROBO1;ROBO2
verapamil Antiarrhythmic Yes Up Semaphorin signaling 0.001002962 1 NaN NRP2;PLXNC1;SEMA6A;SEMA6D
verapamil Antiarrhythmic Yes Down Serine and glycine metabolism 0.045081089 21 NaN SHMT2;SLC1A5
verapamil Antiarrhythmic Yes Up Serotonin inactivation 0.026290423 11 NaN MAOA
verapamil Antiarrhythmic Yes Down Syndecan receptor signaling 0.009285718 8 NaN SDC3;SDC4
verapamil Antiarrhythmic Yes Down Thin myofilament organization 0.000986426 3 NaN ACTA1;TNNI3;TPM2
verapamil Antiarrhythmic Yes Down Thrombospondin receptor signaling 0.005689617 7 NaN THBS2;THBS4
verapamil Antiarrhythmic Yes Up Tropoelastin synthesis 0.013232181 8.5 NaN ELN
verapamil Antiarrhythmic Yes Down Z-disc organization 9.24E-09 1 NaN ACTN2;CSRP3;DES;DYSF;MYPN;NEXN;PDLIM3;TCAP
vemurafenib Kinase inhibitor No Down Adenylyl cyclase signaling pathway 0.007461589 12 NaN ADCY1;PDE4D;RAPGEF4
vemurafenib Kinase inhibitor No Down Adrenergic receptor signaling 0.02079651 17 NaN GRK5;PDE4D;RAPGEF4
vemurafenib Kinase inhibitor No Up Albumin mediated blood protein transport 0.021877205 9.5 NaN ALB
vemurafenib Kinase inhibitor No Down Aspartate and arginine metabolism 0.020733699 15.5 NaN ASS1;SLC7A1
vemurafenib Kinase inhibitor No Up Axonal intermediate filament dynamics 0.009309998 5.5 NaN NEFM;NES
vemurafenib Kinase inhibitor No Up Biglycan synthesis 0.021877205 9.5 NaN BGN
vemurafenib Kinase inhibitor No Down Calcitonin receptor signaling 0.045175089 20.5 NaN RAMP1
vemurafenib Kinase inhibitor No Down CCN intercellular signaling protein family receptor signaling 0.004968548 8 NaN CTGF;CYR61
vemurafenib Kinase inhibitor No Up Cellular cholesterol uptake and efflux 0.031721823 13 NaN ABCA1;ABCG1
vemurafenib Kinase inhibitor No Down Cholesterol synthesis 4.93E-12 1 NaN CYP51A1;DHCR7;FDFT1;FDPS;HMGCR;HMGCS1;MSMO1;MVD;MVK;SQLE
vemurafenib Kinase inhibitor No Down Cholesterol-sensitive control of SREBP activation 0.007340787 10.5 NaN INSIG1;SREBF1
vemurafenib Kinase inhibitor No Up Collagen fibril organization by fibril-associated bridges 0.006746931 4 NaN COL12A1;COL9A3
vemurafenib Kinase inhibitor No Up Decorin synthesis 0.021877205 9.5 NaN DCN
vemurafenib Kinase inhibitor No Down Desaturation of fatty acids 0.010122903 13 NaN FADS2;SCD
vemurafenib Kinase inhibitor No Down Epithelial intermediate filament dynamics 0.013295073 14 NaN KRT19;KRT7
vemurafenib Kinase inhibitor No Down Extracellular matrix breakdown and membrane shedding by adamalysins 0.001973052 6 NaN ADAMTS14;ADAMTS15;ADAMTS17;ADAMTS8
vemurafenib Kinase inhibitor No Up Extracellular matrix breakdown by matrix metalloproteases 0.015505928 7 NaN MMP14;MMP2
vemurafenib Kinase inhibitor No Up Extracellular matrix breakdown by serine proteases 0.009309998 5.5 NaN KLK5;PRSS8
vemurafenib Kinase inhibitor No Up Fibrillar collagen core structure organization 1.11E-06 1 NaN COL11A2;COL1A1;COL1A2;COL5A1;COL5A2
vemurafenib Kinase inhibitor No Down Fibrillar collagen core structure organization 0.001256016 3 NaN COL11A1;COL2A1;COL5A3
vemurafenib Kinase inhibitor No Up Hepatocyte growth factor receptor signaling 0.043277686 15.5 NaN MET
vemurafenib Kinase inhibitor No Down Hepatocyte growth factor receptor signaling 0.045175089 20.5 NaN HGF
vemurafenib Kinase inhibitor No Down Hyaluronan synthesis 0.001536541 4.5 NaN HAS2;HAS3
vemurafenib Kinase inhibitor No Down Inhibition of amyloid aggregation, amyloid degradation and uptake 0.001536541 4.5 NaN A2M;MME
vemurafenib Kinase inhibitor No Down Lipogenesis 0.045175089 20.5 NaN FASN
vemurafenib Kinase inhibitor No Up Methionine cycle 0.043277686 15.5 NaN BHMT
vemurafenib Kinase inhibitor No Up Osteonectin receptor signaling 0.00277824 3 NaN SMOC2;SPOCK1
vemurafenib Kinase inhibitor No Up Osteopontin receptor signaling 0.021877205 9.5 NaN SPP1
vemurafenib Kinase inhibitor No Down Prostaglandin E2 receptor signaling 0.007340787 10.5 NaN PTGER3;RAPGEF4
vemurafenib Kinase inhibitor No Down Restriction point 0.020733699 15.5 NaN CDK6;PFKFB3
vemurafenib Kinase inhibitor No Down Retinol metabolism 0.002845211 7 NaN RDH10;RPE65;TTR
vemurafenib Kinase inhibitor No Down Semaphorin signaling 0.007204299 9 NaN DPYSL3;NRP2;PLXNC1;SEMA3C
vemurafenib Kinase inhibitor No Up Serine and glycine metabolism 0.023018072 12 NaN PHGDH;PSAT1
vemurafenib Kinase inhibitor No Down Serotonin inactivation 0.000520042 2 NaN MAOA;MAOB
vemurafenib Kinase inhibitor No Up Sister chromatid attachment to mitotic spindle 0.043277686 15.5 NaN NUF2
vemurafenib Kinase inhibitor No Up Thrombospondin receptor signaling 4.07E-05 2 NaN CD47;THBS2;THBS4
vemurafenib Kinase inhibitor No Down Tropoelastin synthesis 0.022847565 18 NaN ELN
vemurafenib Kinase inhibitor No Up Vasoactive intestinal peptide receptor signaling 0.043277686 15.5 NaN VIPR2
vemurafenib Kinase inhibitor No Down Vasoactive intestinal peptide receptor signaling 0.045175089 20.5 NaN VIPR1
vemurafenib Kinase inhibitor No Up Z-disc organization 0.046759314 18 NaN CSRP3;DYSF
vandetanib Kinase inhibitor Yes Up Albumin mediated blood protein transport 0.021083275 12 NaN ALB
vandetanib Kinase inhibitor Yes Up Alternative complement pathway 0.004244577 3.5 NaN C1S;CFH
vandetanib Kinase inhibitor Yes Down Biglycan synthesis 0.022759351 8 18 Down by cardiotoxic TKIs BGN
vandetanib Kinase inhibitor Yes Down Cardiomyocyte pacemaker current generation 0.000599569 1 NaN CACNA1G;HCN4;KCNK2
vandetanib Kinase inhibitor Yes Up Cardiomyocyte repolarization during action potential and hyperpolarization 0.002836212 2 NaN KCNA5;KCNIP2;KCNJ2
vandetanib Kinase inhibitor Yes Up CD44-Mediated leukocyte rolling 0.041723865 19 NaN CD44
vandetanib Kinase inhibitor Yes Down Chloride transmembrane transport 0.034116484 13.5 17 Down by cardiotoxic TKIs SLC12A7;SLC26A1
vandetanib Kinase inhibitor Yes Up Cholesterol synthesis 0.008092624 6 22 Up by cardiotoxic TKIs HMGCR;HMGCS1;MSMO1
vandetanib Kinase inhibitor Yes Up Classical complement pathway 0.008668292 7.5 NaN C1R;C1S
vandetanib Kinase inhibitor Yes Up Collagen fibril organization by fibril-associated bridges 0.006278564 5 NaN COL14A1;COL9A1
vandetanib Kinase inhibitor Yes Up Decorin synthesis 0.021083275 12 NaN DCN
vandetanib Kinase inhibitor Yes Down Eicosanoid metabolism 0.044582774 16 NaN CYP2J2;PTGS2
vandetanib Kinase inhibitor Yes Up Endogenous control of complement activity 0.004244577 3.5 NaN CFH;CFI
vandetanib Kinase inhibitor Yes Down Eukaryotic axoneme organization 0.032767128 12 NaN DNAH11;GAS8;SERPINE2
vandetanib Kinase inhibitor Yes Up Extracellular matrix breakdown by matrix metalloproteases 0.014452362 10 NaN MMP1;MMP2
vandetanib Kinase inhibitor Yes Up Fibrillar collagen core structure organization 9.24E-07 1 NaN COL11A1;COL1A1;COL1A2;COL2A1;COL3A1
vandetanib Kinase inhibitor Yes Down Fibulin receptor signaling 0.045002676 18 NaN FBLN1
vandetanib Kinase inhibitor Yes Up G2 M transition checkpoint 0.025418115 15 NaN CCNG1;WEE1
vandetanib Kinase inhibitor Yes Down GABA metabolism 0.007285832 3.5 NaN ABAT;SLC6A1
vandetanib Kinase inhibitor Yes Down Gap junction organization 0.039215592 15 24 Down by cardiotoxic TKIs GJA5;GJD2
vandetanib Kinase inhibitor Yes Up Inhibin receptor signaling 0.011397983 9 NaN INHA;INHBA
vandetanib Kinase inhibitor Yes Down Inhibition of apoptosis 0.029300737 11 NaN BIRC5;BIRC7
vandetanib Kinase inhibitor Yes Up JAK-STAT signaling pathway 0.034093361 17 NaN STAT3;STAT4
vandetanib Kinase inhibitor Yes Down Natriuretic peptide receptor signaling 0.007285832 3.5 NaN NPR1;NPR3
vandetanib Kinase inhibitor Yes Down Notch receptor signaling 0.009974492 5 NaN DLK1;JAG1;LFNG
vandetanib Kinase inhibitor Yes Up Osteopontin receptor signaling 0.021083275 12 NaN SPP1
vandetanib Kinase inhibitor Yes Down Perlecan synthesis 0.022759351 8 NaN HSPG2
vandetanib Kinase inhibitor Yes Down Platelet-derived growth factor receptor signaling 0.024784198 10 14 Down by cardiotoxic TKIs PDGFD;PDGFRB
vandetanib Kinase inhibitor Yes Down Prostacycline receptor signaling 0.045002676 18 NaN PTGIR
vandetanib Kinase inhibitor Yes Down Prostaglandin PGF2 alpha receptor signaling 0.045002676 18 NaN PTGFR
vandetanib Kinase inhibitor Yes Up Retinol metabolism 0.029628054 16 NaN ALDH1A1;ALDH1A3
vandetanib Kinase inhibitor Yes Down Retinol metabolism 0.034116484 13.5 NaN DHRS3;RLBP1
vandetanib Kinase inhibitor Yes Down Roundabout signaling 0.010047711 6 NaN ROBO1;ROBO2
vandetanib Kinase inhibitor Yes Up Serine and glycine metabolism 0.02147651 14 19 Up by cardiotoxic TKIs PSAT1;SLC1A5
vandetanib Kinase inhibitor Yes Up Serotonin inactivation 0.041723865 19 NaN MAOA
vandetanib Kinase inhibitor Yes Up Thin myofilament organization 0.008668292 7.5 NaN ACTA1;LMOD3
vandetanib Kinase inhibitor Yes Down Thrombospondin receptor signaling 0.003003699 2 NaN THBS2;THBS4
vandetanib Kinase inhibitor Yes Down Tropoelastin synthesis 0.022759351 8 NaN ELN
vandetanib Kinase inhibitor Yes Up Vasoactive intestinal peptide receptor signaling 0.041723865 19 NaN VIPR2
trastuzumab Monoclonal antibody Yes Up Aggrecan synthesis 0.023288638 11.5 NaN ACAN
trastuzumab Monoclonal antibody Yes Up Albumin mediated blood protein transport 0.023288638 11.5 NaN ALB
trastuzumab Monoclonal antibody Yes Down Biglycan synthesis 0.021083275 16 18 Down by cardiotoxic TKIs BGN
trastuzumab Monoclonal antibody Yes Up Cardiomyocyte depolarization during action potential 0.023288638 11.5 NaN SCN5A
trastuzumab Monoclonal antibody Yes Down CCN intercellular signaling protein family receptor signaling 0.004244577 7 NaN CTGF;CYR61
trastuzumab Monoclonal antibody Yes Down CD44-Mediated leukocyte rolling 0.041723865 22.5 NaN CD44
trastuzumab Monoclonal antibody Yes Down Centrosome separation 0.000995243 2 NaN CCNB1;CDK1;ESPL1
trastuzumab Monoclonal antibody Yes Down Cholesterol synthesis 0.008092624 12 NaN DHCR24;DHCR7;MVK
trastuzumab Monoclonal antibody Yes Down Cholesterol-sensitive control of SREBP activation 0.006278564 9.5 NaN INSIG1;SREBF1
trastuzumab Monoclonal antibody Yes Up Collagen fiber crosslinking 0.005158008 3 NaN LOX;PXDN
trastuzumab Monoclonal antibody Yes Up Collagen fibril organization by fibril-associated bridges 0.007618457 4 NaN COL14A1;COL9A2
trastuzumab Monoclonal antibody Yes Down Decorin synthesis 0.021083275 16 NaN DCN
trastuzumab Monoclonal antibody Yes Up Epithelial intermediate filament dynamics 0.013789873 5 NaN KRT7;TCHH
trastuzumab Monoclonal antibody Yes Up Extracellular matrix breakdown and membrane shedding by adamalysins 0.017608297 7 NaN ADAM33;ADAMTS2;ADAMTS8
trastuzumab Monoclonal antibody Yes Up Extracellular matrix breakdown by cathepsins 0.021492826 8.5 NaN CTSH;CTSV
trastuzumab Monoclonal antibody Yes Up Fibrillar collagen core structure organization 0.021492826 8.5 NaN COL11A1;COL2A1
trastuzumab Monoclonal antibody Yes Down Fibrillar collagen core structure organization 3.66E-05 1 NaN COL1A1;COL1A2;COL3A1;COL5A2
trastuzumab Monoclonal antibody Yes Down G2 M transition checkpoint 0.025418115 19 NaN CCNB1;CDK1
trastuzumab Monoclonal antibody Yes Down GABA metabolism 0.006278564 9.5 NaN ABAT;SLC6A1
trastuzumab Monoclonal antibody Yes Down Glycolysis and Gluconeogenesis 0.012002569 13 NaN ENO1;HK2;LDHA
trastuzumab Monoclonal antibody Yes Up Granulocyte macrophage colony-stimulating factor receptor signaling 0.046036922 16 NaN JAK2
trastuzumab Monoclonal antibody Yes Down Inhibition of amyloid aggregation, amyloid degradation and uptake 0.001309537 3 NaN A2M;PLAT
trastuzumab Monoclonal antibody Yes Up Inhibition of apoptosis 0.030574288 14 NaN IFI6;XAF1
trastuzumab Monoclonal antibody Yes Down Insulin receptor signaling 0.038801493 20 NaN IRS1;IRS2
trastuzumab Monoclonal antibody Yes Down Lipogenesis 0.041723865 22.5 NaN FASN
trastuzumab Monoclonal antibody Yes Up Methionine cycle 0.046036922 16 NaN BHMT
trastuzumab Monoclonal antibody Yes Down Microfibril scaffold organization 0.041723865 22.5 NaN FBN1
trastuzumab Monoclonal antibody Yes Down Mitotic spindle disassembly 0.021083275 16 NaN CDK1
trastuzumab Monoclonal antibody Yes Down Natriuretic peptide receptor signaling 0.006278564 9.5 NaN NPPA;NPPB
trastuzumab Monoclonal antibody Yes Up Osteopontin receptor signaling 0.023288638 11.5 NaN SPP1
trastuzumab Monoclonal antibody Yes Down Platelet-derived growth factor receptor signaling 0.001347236 4.5 14 Down by cardiotoxic TKIs PDGFRA;PDGFRB;TNK2
trastuzumab Monoclonal antibody Yes Up Removal of caspase inhibition 0.046036922 16 NaN XAF1
trastuzumab Monoclonal antibody Yes Up Retinol metabolism 0.003003835 2 NaN ALDH1A1;ALDH1A2;ALDH1A3
trastuzumab Monoclonal antibody Yes Down Serine and glycine metabolism 0.001347236 4.5 NaN PHGDH;PSAT1;SHMT2
trastuzumab Monoclonal antibody Yes Down Sister chromatid segregation 0.006278564 9.5 NaN ESPL1;TOP2A
trastuzumab Monoclonal antibody Yes Up Thick myofilament organization 0.00159608 1 NaN MYBPC3;MYH7
trastuzumab Monoclonal antibody Yes Down Thrombospondin receptor signaling 0.002582626 6 NaN THBS1;THBS4
trastuzumab Monoclonal antibody Yes Down Tropoelastin synthesis 0.021083275 16 NaN ELN
trastuzumab Monoclonal antibody Yes Down Versican receptor signaling 0.041723865 22.5 NaN VCAN
trastuzumab Monoclonal antibody Yes Down Versican synthesis 0.021083275 16 NaN VCAN
trastuzumab Monoclonal antibody Yes Up WNT-Beta-catenin signaling pathway 0.016465738 6 NaN CTHRC1;FZD2;SFRP4;SFRP5;WNT2
trastuzumab Monoclonal antibody Yes Down WNT-Beta-catenin signaling pathway 0.045815603 25 NaN DACT1;FZD7;SFRP2;WNT1
trametinib Kinase inhibitor Yes Up Aggrecan synthesis 0.015878617 4.5 NaN ACAN
trametinib Kinase inhibitor Yes Up Androgen receptor signaling 0.031506482 9 NaN AR
trametinib Kinase inhibitor Yes Down Axonal intermediate filament dynamics 0.017816684 25.5 NaN NEFL;NES
trametinib Kinase inhibitor Yes Down CCN intercellular signaling protein family receptor signaling 0.008837033 20.5 NaN CTGF;CYR61
trametinib Kinase inhibitor Yes Up Cellular iron storage 0.046887533 10.5 NaN FTL
trametinib Kinase inhibitor Yes Down Centrosome maturation 0.005133558 16.5 NaN AURKA;PLK1;TPX2
trametinib Kinase inhibitor Yes Down Centrosome organization 0.004701563 15 NaN ASPM;NEK2;PLK4;POC1A;STIL;TACC3;WDR62
trametinib Kinase inhibitor Yes Down Centrosome separation 3.11E-11 1 NaN AURKA;CCNB1;CDK1;ESPL1;KIF11;NEK2;NEK6;SPAG5
trametinib Kinase inhibitor Yes Down Cholesterol synthesis 0.022193047 27 NaN DHCR24;DHCR7;MVK
trametinib Kinase inhibitor Yes Down Collagen fibril organization by fibril-associated bridges 0.012987834 23 NaN COL9A1;COL9A2
trametinib Kinase inhibitor Yes Down Contractile ring constriction 0.000273952 7.5 NaN ANLN;ECT2;MYLK
trametinib Kinase inhibitor Yes Up Decorin synthesis 0.015878617 4.5 NaN DCN
trametinib Kinase inhibitor Yes Down Desaturation of fatty acids 0.017816684 25.5 NaN FADS2;SCD
trametinib Kinase inhibitor Yes Down DNA replication elongation 0.008837033 20.5 NaN MCM5;MCM7
trametinib Kinase inhibitor Yes Down DNA replication initiation 7.21E-06 4 NaN CDC45;CDC6;GINS1;GINS2;MCM10;MCM5;MCM7
trametinib Kinase inhibitor Yes Down Equatorial RhoA activation 0.005411801 18.5 NaN ECT2;KIF23
trametinib Kinase inhibitor Yes Down Eukaryotic kinetochore dynamics 7.66E-10 2 NaN BUB1;CENPE;CENPF;CENPI;CENPU;MAD2L1;NDC80;NUF2;SKA3;SPC24;TTK;ZWINT
trametinib Kinase inhibitor Yes Down Extracellular matrix breakdown by heparanases and sulfatases 0.005411801 18.5 NaN SULF1;SULF2
trametinib Kinase inhibitor Yes Down Fanconi anemia interstrand cross-link repair pathway 0.001023657 13 NaN BRIP1;FANCA;FANCD2;FANCI;UBE2T
trametinib Kinase inhibitor Yes Up Fibrillar collagen core structure organization 1.20E-05 1 NaN COL1A1;COL1A2;COL3A1;COL5A1
trametinib Kinase inhibitor Yes Down G2 M transition checkpoint 0.005133558 16.5 NaN CCNB1;CDC25C;CDK1
trametinib Kinase inhibitor Yes Up Hemoglobin and myoglobin synthesis 0.046887533 10.5 NaN MB
trametinib Kinase inhibitor Yes Down Intracellular bridge assembly 0.002761969 14 NaN INCENP;KIF23
trametinib Kinase inhibitor Yes Down Metaphase to anaphase checkpoint 6.57E-06 3 NaN BUB1;BUB1B;CCNB2;CDC20;CENPE;MAD2L1;PTTG1;TTK
trametinib Kinase inhibitor Yes Down Mitotic chromosome condensation 0.000915708 11 NaN INCENP;NCAPG2;SMC4
trametinib Kinase inhibitor Yes Down Mitotic H3 phosphorylation and dephosphorylation 0.000273952 7.5 NaN AURKB;CCNA2;INCENP
trametinib Kinase inhibitor Yes Down Mitotic spindle assembly 2.78E-05 5 NaN DLGAP5;NUSAP1;TACC3;TPX2;TTK
trametinib Kinase inhibitor Yes Down Natriuretic peptide receptor signaling 0.012987834 23 NaN NPPA;NPPB
trametinib Kinase inhibitor Yes Down Nuclear intermediate filaments 0.012987834 23 NaN LMNB1;LMNB2
trametinib Kinase inhibitor Yes Up Potassium transmembrane transport 0.000509517 2 7 Up by cardiotoxic TKIs ABCC9;ATP1A2;FXYD1;SLC12A6
trametinib Kinase inhibitor Yes Down Pyrimidine synthesis and salvage 0.023278285 28 NaN TK1;TYMS
trametinib Kinase inhibitor Yes Down Retinol metabolism 0.000500941 9 NaN ALDH1A1;ALDH1A3;DHRS3;RDH10
trametinib Kinase inhibitor Yes Up Semaphorin signaling 0.016421671 6 NaN NRP2;SEMA6A;SEMA6D
trametinib Kinase inhibitor Yes Down Sister chromatid attachment to mitotic spindle 0.000939783 12 NaN NUF2;TACC3
trametinib Kinase inhibitor Yes Down Sister chromatid segregation 0.000535432 10 NaN ESPL1;PTTG1;TOP2A
trametinib Kinase inhibitor Yes Up Thin myofilament organization 0.004996504 3 NaN ACTA1;LMOD3
trametinib Kinase inhibitor Yes Down Thrombospondin receptor signaling 0.000112137 6 NaN THBS1;THBS2;THBS4
trametinib Kinase inhibitor Yes Up WNT-Beta-catenin signaling pathway 0.018655736 7 NaN AMER1;FZD1;SFRP1;SFRP2
trametinib Kinase inhibitor Yes Up Z-disc organization 0.025999312 8 NaN CSRP3;TCAP
tofacitinib Kinase inhibitor No Down Aggrecan synthesis 0.026199718 12.5 NaN ACAN
tofacitinib Kinase inhibitor No Up Albumin mediated blood protein transport 0.018966126 9 NaN ALB
tofacitinib Kinase inhibitor No Up Androgen receptor signaling 0.037574179 14 NaN AR
tofacitinib Kinase inhibitor No Down Antigen presentation via MHC class I molecules 0.026793335 14 NaN HLA-B;HLA-C
tofacitinib Kinase inhibitor No Up Biglycan synthesis 0.018966126 9 NaN BGN
tofacitinib Kinase inhibitor No Up CCN intercellular signaling protein family receptor signaling 6.54E-05 4 NaN CTGF;CYR61;WISP1
tofacitinib Kinase inhibitor No Up Cellular fatty acid uptake 0.037574179 14 NaN CD36
tofacitinib Kinase inhibitor No Up Chaperone-mediated autophagy 0.037574179 14 NaN HSPA8
tofacitinib Kinase inhibitor No Down Cholesterol synthesis 1.94E-08 1 NaN CYP51A1;DHCR7;HMGCR;HMGCS1;MSMO1;MVD;SC5D;SQLE
tofacitinib Kinase inhibitor No Down Cholesterol-sensitive control of SREBP activation 0.009570814 7.5 NaN INSIG1;SREBF1
tofacitinib Kinase inhibitor No Down Classical complement pathway 0.013168643 9 NaN C1QA;C1R
tofacitinib Kinase inhibitor No Up Coagulation cascade 0.02085161 11 NaN F2RL1;TFPI
tofacitinib Kinase inhibitor No Up Collagen fibril organization by fibril-associated bridges 0.005107525 5 NaN COL14A1;COL9A1
tofacitinib Kinase inhibitor No Down Collagen fibril organization by fibril-associated bridges 0.009570814 7.5 NaN COL9A2;COL9A3
tofacitinib Kinase inhibitor No Up Decorin synthesis 0.018966126 9 NaN DCN
tofacitinib Kinase inhibitor No Up DNA replication elongation 6.20E-07 3 NaN MCM4;MCM5;MCM7;PCNA
tofacitinib Kinase inhibitor No Up DNA replication initiation 2.88E-07 1 NaN CDC45;CDC6;MCM3;MCM4;MCM5;MCM6;MCM7
tofacitinib Kinase inhibitor No Down Epithelial intermediate filament dynamics 0.01725681 10 NaN KRT19;KRT8
tofacitinib Kinase inhibitor No Up Extracellular matrix breakdown by cathepsins 0.014575224 6.5 NaN CTSF;CTSV
tofacitinib Kinase inhibitor No Up Fibrillar collagen core structure organization 5.46E-07 2 NaN COL11A1;COL1A1;COL1A2;COL2A1;COL3A1
tofacitinib Kinase inhibitor No Down Glutamate and glutamine metabolism 0.044111632 16.5 NaN SLC1A5;SLC7A5
tofacitinib Kinase inhibitor No Down Granulocyte-colony stimulating factor receptor signaling 0.021807329 11 NaN SOCS3;STAT3
tofacitinib Kinase inhibitor No Down Inhibition of amyloid aggregation, amyloid degradation and uptake 0.002016908 4 NaN A2M;MME
tofacitinib Kinase inhibitor No Down Leptin receptor signaling 0.003963971 5 NaN SOCS3;STAT3
tofacitinib Kinase inhibitor No Up Microfibril scaffold organization 0.037574179 14 NaN FBN1
tofacitinib Kinase inhibitor No Up Myofibril formation 0.014575224 6.5 NaN KLHL41;XIRP1
tofacitinib Kinase inhibitor No Down Oncostatin-M receptor signaling 0.006492473 6 NaN OSMR;STAT3
tofacitinib Kinase inhibitor No Down Retinol metabolism 0.044111632 16.5 NaN DHRS3;RDH10
tofacitinib Kinase inhibitor No Down Serine and glycine metabolism 0.032189046 15 NaN PHGDH;SLC1A5
tofacitinib Kinase inhibitor No Up Serotonin inactivation 0.037574179 14 NaN MAOA
tofacitinib Kinase inhibitor No Down Thin myofilament organization 0.000576244 2 NaN ACTA1;NEBL;TNNI3
tofacitinib Kinase inhibitor No Down Tropoelastin synthesis 0.026199718 12.5 NaN ELN
tofacitinib Kinase inhibitor No Down Z-disc organization 0.000655008 3 NaN CSRP3;DES;NEBL;PDLIM3
tnf-alpha Cytokine Up Albumin mediated blood protein transport 0.017025406 8.5 NaN ALB
tnf-alpha Cytokine Up Antigen presentation via MHC class I molecules 0.011861068 5.5 NaN B2M;HLA-B
tnf-alpha Cytokine Down Biglycan synthesis 0.028140438 18 NaN BGN
tnf-alpha Cytokine Up Cardiomyocyte repolarization during action potential and hyperpolarization 0.022939425 11.5 NaN KCNIP2;KCNQ5
tnf-alpha Cytokine Up Cellular fatty acid uptake 0.033762424 14 NaN CD36
tnf-alpha Cytokine Down Centrosome maturation 0.043251813 22 NaN PLK1;TPX2
tnf-alpha Cytokine Down Centrosome separation 0.002286708 6 NaN CCNB1;KIF11;SPAG5
tnf-alpha Cytokine Down Cholesterol synthesis 1.26E-09 1 NaN CYP51A1;DHCR7;HMGCR;HMGCS1;MSMO1;MVD;MVK;NSDHL;SQLE
tnf-alpha Cytokine Up Collagen fibril organization by fibril-associated bridges 9.36E-05 1 NaN COL14A1;COL19A1;COL9A3
tnf-alpha Cytokine Down Contractile ring constriction 0.007462268 10.5 NaN ANLN;MYLK
tnf-alpha Cytokine Up Decorin synthesis 0.017025406 8.5 NaN DCN
tnf-alpha Cytokine Down Desaturation of fatty acids 0.000710301 5 NaN FADS2;FADS3;SCD
tnf-alpha Cytokine Down Epithelial intermediate filament dynamics 0.01975769 16 NaN KRT7;KRT8
tnf-alpha Cytokine Down Eukaryotic kinetochore dynamics 0.000611459 4 NaN BUB1;CENPF;NDC80;SPC24;TTK;ZWINT
tnf-alpha Cytokine Up Extracellular matrix breakdown and membrane shedding by adamalysins 0.000662661 2 NaN ADAM12;ADAMTS1;ADAMTS5;ADAMTS6
tnf-alpha Cytokine Down Extracellular matrix breakdown and membrane shedding by adamalysins 0.028853674 20 NaN ADAM19;ADAMTS15;ADAMTS8
tnf-alpha Cytokine Up Fibrillar collagen core structure organization 0.011861068 5.5 NaN COL11A2;COL3A1
tnf-alpha Cytokine Down Gluthatione conjugation 0.028140438 18 NaN GSTP1
tnf-alpha Cytokine Down Glycolysis and Gluconeogenesis 0.003568606 8 NaN ALDOA;ENO1;LDHA;TPI1
tnf-alpha Cytokine Up Granulocyte macrophage colony-stimulating factor receptor signaling 0.033762424 14 NaN JAK2
tnf-alpha Cytokine Up Granulocyte-colony stimulating factor receptor signaling 0.009595627 4 NaN SOCS3;STAT3
tnf-alpha Cytokine Up JAK-STAT signaling pathway 0.022939425 11.5 NaN SOCS3;STAT3
tnf-alpha Cytokine Up Leptin receptor signaling 0.001691693 3 NaN SOCS3;STAT3
tnf-alpha Cytokine Down Metaphase to anaphase checkpoint 0.002433212 7 NaN BUB1;CCNB2;CDC20;PTTG1;TTK
tnf-alpha Cytokine Up Methionine cycle 0.033762424 14 NaN BHMT
tnf-alpha Cytokine Down Mitotic H3 phosphorylation and dephosphorylation 0.007462268 10.5 NaN AURKB;CCNA2
tnf-alpha Cytokine Down Mitotic spindle assembly 0.000359811 3 NaN DLGAP5;TACC3;TPX2;TTK
tnf-alpha Cytokine Down Natriuretic peptide receptor signaling 0.010986142 13.5 NaN NPPA;NPPB
tnf-alpha Cytokine Up Neuregulin receptor signaling 0.014335775 7 NaN ERBB3;SH3TC2
tnf-alpha Cytokine Down Platelet-derived growth factor receptor signaling 0.036713271 21 NaN PDGFB;TNK2
tnf-alpha Cytokine Down Protein polyubiquitination 0.009416278 12 NaN ISG15;UBE2S;UCHL1
tnf-alpha Cytokine Down Retinol metabolism 0.005118789 9 NaN DHRS3;RBP1;RDH10
tnf-alpha Cytokine Up Semaphorin signaling 0.019739244 10 NaN SEMA3D;SEMA6A;SEMA6D
tnf-alpha Cytokine Down Serine and glycine metabolism 0.000173654 2 NaN PHGDH;PSAT1;SHMT2;SLC1A5
tnf-alpha Cytokine Down Sister chromatid segregation 0.010986142 13.5 NaN PTTG1;TOP2A
tnf-alpha Cytokine Down Thin myofilament organization 0.015096478 15 NaN ACTA1;TPM4
tnf-alpha Cytokine Down Tropoelastin synthesis 0.028140438 18 NaN ELN
sunitinib Kinase inhibitor Yes Down Aggrecan synthesis 0.023023994 9.5 NaN ACAN
sunitinib Kinase inhibitor Yes Up Albumin mediated blood protein transport 0.019936486 9 NaN ALB
sunitinib Kinase inhibitor Yes Up Biglycan synthesis 0.019936486 9 NaN BGN
sunitinib Kinase inhibitor Yes Down CCN intercellular signaling protein family receptor signaling 0.0001166 2 NaN CTGF;CYR61;WISP1
sunitinib Kinase inhibitor Yes Down CD44-Mediated leukocyte rolling 0.045519869 15 NaN CD44
sunitinib Kinase inhibitor Yes Down Cellular cholesterol uptake and efflux 0.034848653 11.5 23 Down by cardiotoxic TKIs ABCA1;ARL4C
sunitinib Kinase inhibitor Yes Down Centrosome separation 0.021035933 8 NaN ESPL1;SPAG5
sunitinib Kinase inhibitor Yes Down Classical complement pathway 0.000394321 4.5 NaN C1QB;C1QC;C1R
sunitinib Kinase inhibitor Yes Up Extracellular matrix breakdown and membrane shedding by adamalysins 0.001194517 4 NaN ADAM33;ADAMTS15;ADAMTS5;ADAMTS8
sunitinib Kinase inhibitor Yes Up Extracellular matrix breakdown by cathepsins 0.016025171 6.5 NaN CTSF;CTSV
sunitinib Kinase inhibitor Yes Up Extracellular matrix breakdown by matrix metalloproteases 0.000601039 3 NaN MMP12;MMP2;MMP3
sunitinib Kinase inhibitor Yes Up Fibrillar collagen core structure organization 7.00E-07 1 NaN COL11A2;COL1A1;COL1A2;COL2A1;COL3A1
sunitinib Kinase inhibitor Yes Down Fibulin receptor signaling 0.045519869 15 NaN FBLN1
sunitinib Kinase inhibitor Yes Up Granulocyte macrophage colony-stimulating factor receptor signaling 0.039477231 12.5 NaN JUND
sunitinib Kinase inhibitor Yes Down Hepatocyte growth factor receptor signaling 0.00052812 6 NaN HGF;MET
sunitinib Kinase inhibitor Yes Down Inhibition of amyloid aggregation, amyloid degradation and uptake 1.21E-05 1 NaN A2M;MME;PLAT
sunitinib Kinase inhibitor Yes Down Methionine cycle 0.045519869 15 NaN BHMT
sunitinib Kinase inhibitor Yes Up Microfibril scaffold organization 0.039477231 12.5 NaN FBN1
sunitinib Kinase inhibitor Yes Down Mineralocorticoid receptor signaling 0.045519869 15 NaN GPER1
sunitinib Kinase inhibitor Yes Up Osteonectin receptor signaling 3.08E-05 2 NaN SMOC2;SPARC;SPOCK1
sunitinib Kinase inhibitor Yes Down Progesterone receptor signaling 0.023023994 9.5 NaN PGR
sunitinib Kinase inhibitor Yes Up Prostaglandin PGF2 alpha receptor signaling 0.039477231 12.5 NaN PTGFR
sunitinib Kinase inhibitor Yes Up Protein polyubiquitination 0.039518883 15 NaN ISG15;UCHL1
sunitinib Kinase inhibitor Yes Up Restriction point 0.016025171 6.5 3 Up by cardiotoxic TKIs CCND2;CDKN1A
sunitinib Kinase inhibitor Yes Down Retinol metabolism 0.034848653 11.5 NaN ALDH1A3;DHRS3
sunitinib Kinase inhibitor Yes Up Serotonin inactivation 0.039477231 12.5 NaN MAOA
sunitinib Kinase inhibitor Yes Down Serotonin inactivation 0.045519869 15 NaN MAOB
sunitinib Kinase inhibitor Yes Down Sister chromatid segregation 0.000229227 3 NaN ESPL1;PTTG1;TOP2A
sunitinib Kinase inhibitor Yes Down Thin myofilament organization 0.000394321 4.5 21 Down by cardiotoxic TKIs ACTA1;LMOD3;TNNI3
sunitinib Kinase inhibitor Yes Up Tropoelastin synthesis 0.019936486 9 NaN ELN
sunitinib Kinase inhibitor Yes Up WNT-Beta-catenin signaling pathway 0.008849032 5 NaN AXIN2;FZD2;FZD8;PAX6;WNT5A
sunitinib Kinase inhibitor Yes Down Z-disc organization 0.005410758 7 NaN DYSF;PDLIM3;TCAP
sorafenib Kinase inhibitor Yes Down Albumin mediated blood protein transport 0.019848271 9.5 NaN ALB
sorafenib Kinase inhibitor Yes Down Antigen presentation via MHC class I molecules 0.015890842 5 NaN HLA-B;HLA-C
sorafenib Kinase inhibitor Yes Up CD44-Mediated leukocyte rolling 0.048447984 24.5 NaN CD44
sorafenib Kinase inhibitor Yes Up Centrosome maturation 0.002723606 10 NaN AURKA;PLK1;TPX2
sorafenib Kinase inhibitor Yes Up Centrosome organization 0.00632086 13 NaN ASPM;ATF5;NEK2;PLK3;TACC3;WDR62
sorafenib Kinase inhibitor Yes Up Centrosome separation 5.58E-10 1 NaN AURKA;CCNB1;CDK1;ESPL1;KIF11;NEK2;SPAG5
sorafenib Kinase inhibitor Yes Up Cholesterol synthesis 0.012211764 15 22 Up by cardiotoxic TKIs DHCR7;MVD;MVK
sorafenib Kinase inhibitor Yes Up Collagen fiber crosslinking 0.005706386 12 NaN LOXL1;PXDN
sorafenib Kinase inhibitor Yes Down Decorin synthesis 0.019848271 9.5 NaN DCN
sorafenib Kinase inhibitor Yes Up Desaturation of fatty acids 0.011600172 14 11 Up by cardiotoxic TKIs FADS2;SCD
sorafenib Kinase inhibitor Yes Down Epithelial intermediate filament dynamics 0.010149397 2.5 NaN KRT19;KRT7
sorafenib Kinase inhibitor Yes Up Eukaryotic kinetochore dynamics 3.05E-06 3 NaN BUB1;CENPE;CENPF;NDC80;NUF2;SPC24;TTK;ZWINT
sorafenib Kinase inhibitor Yes Down Extracellular matrix breakdown by cathepsins 0.015890842 5 NaN CTSF;CTSV
sorafenib Kinase inhibitor Yes Down Fibrillar collagen core structure organization 0.015890842 5 NaN COL1A2;COL3A1
sorafenib Kinase inhibitor Yes Up Fibulin receptor signaling 0.048447984 24.5 NaN FBLN1
sorafenib Kinase inhibitor Yes Up G2 M transition checkpoint 0.0336321 20.5 NaN CCNB1;CDK1
sorafenib Kinase inhibitor Yes Up Gap junction organization 0.004345619 11 NaN GJA1;GJA5;GJB2
sorafenib Kinase inhibitor Yes Down Granulocyte macrophage colony-stimulating factor receptor signaling 0.039304304 17.5 NaN JAK2
sorafenib Kinase inhibitor Yes Up Hepatocyte growth factor receptor signaling 0.048447984 24.5 NaN HGF
sorafenib Kinase inhibitor Yes Up Hyaluronan-mediated motility receptor signaling 0.024523641 17 NaN HMMR
sorafenib Kinase inhibitor Yes Up Inhibition of apoptosis 0.0336321 20.5 NaN BIRC5;XAF1
sorafenib Kinase inhibitor Yes Down Interferon alpha receptor signaling 0.010149397 2.5 NaN IRF9;STAT1
sorafenib Kinase inhibitor Yes Down Interferon beta receptor signaling 0.007712399 1 NaN IFIT2;IRF9
sorafenib Kinase inhibitor Yes Up Intracellular bridge assembly 0.001768708 8 NaN INCENP;KIF23
sorafenib Kinase inhibitor Yes Down JAK-STAT signaling pathway 0.030506558 13 NaN SOCS2;STAT1
sorafenib Kinase inhibitor Yes Up Lipogenesis 0.048447984 24.5 NaN FASN
sorafenib Kinase inhibitor Yes Down Mammalian target of rapamycin signaling pathway 0.043858476 20 NaN PIK3R1;RICTOR
sorafenib Kinase inhibitor Yes Up Metaphase to anaphase checkpoint 8.64E-08 2 NaN BUB1;BUB1B;CCNB2;CDC20;CENPE;MXD3;PLK3;PTTG1;TTK
sorafenib Kinase inhibitor Yes Down Methionine cycle 0.039304304 17.5 NaN BHMT
sorafenib Kinase inhibitor Yes Down Microfibril scaffold organization 0.039304304 17.5 NaN FBN1
sorafenib Kinase inhibitor Yes Up Mitotic H3 phosphorylation and dephosphorylation 0.000140678 5 NaN AURKB;CCNA2;INCENP
sorafenib Kinase inhibitor Yes Up Mitotic spindle assembly 9.37E-06 4 NaN DLGAP5;NUSAP1;TACC3;TPX2;TTK
sorafenib Kinase inhibitor Yes Up Mitotic spindle disassembly 0.024523641 17 NaN CDK1
sorafenib Kinase inhibitor Yes Down Osteopontin receptor signaling 0.019848271 9.5 NaN SPP1
sorafenib Kinase inhibitor Yes Up Platelet-derived growth factor receptor signaling 0.028480684 19 NaN FOSL1;TNK2
sorafenib Kinase inhibitor Yes Down Platelet-derived growth factor receptor signaling 0.019170669 7 14 Down by cardiotoxic TKIs PDGFRA;RGS5
sorafenib Kinase inhibitor Yes Up Removal of caspase inhibition 0.048447984 24.5 NaN XAF1
sorafenib Kinase inhibitor Yes Down Retinol metabolism 0.02648975 12 NaN ALDH1A1;ALDH1A3
sorafenib Kinase inhibitor Yes Up Semaphorin signaling 0.049939927 28 NaN PLXNA2;PLXNA4;RND1
sorafenib Kinase inhibitor Yes Up Serine and glycine metabolism 0.002080203 9 19 Up by cardiotoxic TKIs PHGDH;PSAT1;SHMT2
sorafenib Kinase inhibitor Yes Down Serotonin inactivation 0.039304304 17.5 NaN MAOA
sorafenib Kinase inhibitor Yes Up Sister chromatid attachment to mitotic spindle 0.000599299 7 NaN NUF2;TACC3
sorafenib Kinase inhibitor Yes Up Sister chromatid segregation 0.000276247 6 NaN ESPL1;PTTG1;TOP2A
sorafenib Kinase inhibitor Yes Down Tropoelastin synthesis 0.019848271 9.5 NaN ELN
sorafenib Kinase inhibitor Yes Up Versican receptor signaling 0.048447984 24.5 NaN VCAN
sorafenib Kinase inhibitor Yes Up Versican synthesis 0.024523641 17 NaN VCAN
sorafenib Kinase inhibitor Yes Down WNT-Beta-catenin signaling pathway 0.03806357 14 NaN FRZB;PAX6;SFRP2;WNT9A
sorafenib Kinase inhibitor Yes Down Z-disc organization 0.039201142 15 NaN CSRP3;PDLIM3
saxagliptin Antidiabetic No Down Actin filament bundling and crosslinking 0.019555227 13 NaN SYNPO;SYNPO2;USH1C
saxagliptin Antidiabetic No Up Actin filament severing and depolymerization 0.03363188 13.5 NaN SCIN;TAGLN2
saxagliptin Antidiabetic No Up Aggrecan synthesis 0.022582922 11.5 NaN ACAN
saxagliptin Antidiabetic No Down Albumin mediated blood protein transport 0.022318278 16 NaN ALB
saxagliptin Antidiabetic No Down Biglycan synthesis 0.022318278 16 NaN BGN
saxagliptin Antidiabetic No Down Cellular cholesterol uptake and efflux 0.000147809 2 NaN ABCA1;ABCA12;ABCG1;SCARA3
saxagliptin Antidiabetic No Down Centrosome separation 0.001173699 4.5 NaN CCNB1;CDK1;NEK2
saxagliptin Antidiabetic No Up Chloride transmembrane transport 0.03363188 13.5 NaN ANO1;SLC12A6
saxagliptin Antidiabetic No Up Classical complement pathway 0.000372505 1 NaN C1QA;C1QB;C1QC
saxagliptin Antidiabetic No Down Collagen fibril organization by fibril-associated bridges 0.000209049 3 NaN COL12A1;COL14A1;COL9A1
saxagliptin Antidiabetic No Up Decorin synthesis 0.022582922 11.5 NaN DCN
saxagliptin Antidiabetic No Up DNA replication initiation 0.002211379 4 NaN CDC6;MCM10;MCM5;MCM6
saxagliptin Antidiabetic No Down Epithelial intermediate filament dynamics 0.012712092 9 NaN KRT19;KRT8
saxagliptin Antidiabetic No Up Extracellular matrix breakdown and membrane shedding by adamalysins 0.01622804 9 NaN ADAMTS2;ADAMTS5;ADAMTS9
saxagliptin Antidiabetic No Down Extracellular matrix breakdown by serine proteases 0.009675618 8 NaN KLK5;PRSS12
saxagliptin Antidiabetic No Up Fibrillar collagen core structure organization 0.001214412 2 NaN COL1A1;COL1A2;COL3A1
saxagliptin Antidiabetic No Down Fibrillar collagen core structure organization 0.001173699 4.5 NaN COL11A1;COL2A1;COL5A2
saxagliptin Antidiabetic No Down Fibronectin synthesis and extracellular assembly 0.000106279 1 NaN FN1;ITGA5;ITGB3
saxagliptin Antidiabetic No Down G2 M transition checkpoint 0.028256676 19 NaN CCNB1;CDK1
saxagliptin Antidiabetic No Up Glutamate and glutamine metabolism 0.002752604 5 NaN GLS;SLC1A5;SLC7A5
saxagliptin Antidiabetic No Down Granulocyte-colony stimulating factor receptor signaling 0.016105455 12 NaN SOCS3;STAT3
saxagliptin Antidiabetic No Up Hepatocyte growth factor receptor signaling 0.044657802 15.5 NaN HGF
saxagliptin Antidiabetic No Up HIF-1 receptor signaling pathway 0.016470005 10 NaN CITED2;EGLN3
saxagliptin Antidiabetic No Up Inhibin receptor signaling 0.013002108 8 NaN INHBB;INHBE
saxagliptin Antidiabetic No Down JAK-STAT signaling pathway 0.037839911 20 NaN SOCS3;STAT3
saxagliptin Antidiabetic No Down Leptin receptor signaling 0.002889904 7 NaN SOCS3;STAT3
saxagliptin Antidiabetic No Down Microfibril scaffold organization 0.044140376 21 NaN FBN1
saxagliptin Antidiabetic No Down Mitotic spindle assembly 0.002661905 6 NaN DLGAP5;NUSAP1;TPX2
saxagliptin Antidiabetic No Down Mitotic spindle disassembly 0.022318278 16 NaN CDK1
saxagliptin Antidiabetic No Up Natriuretic peptide receptor signaling 0.007176501 7 NaN NPPB;NPR3
saxagliptin Antidiabetic No Down Osteopontin receptor signaling 0.022318278 16 NaN SPP1
saxagliptin Antidiabetic No Down Potassium transmembrane transport 0.015726997 11 NaN ABCC9;ATP1A2;ATP1A3
saxagliptin Antidiabetic No Up Protein polyubiquitination 0.049507089 17 NaN ISG15;UCHL1
saxagliptin Antidiabetic No Up Serine and glycine metabolism 0.00164207 3 NaN GLDC;PSAT1;SLC1A5
saxagliptin Antidiabetic No Up Serotonin inactivation 0.044657802 15.5 NaN MAOA
saxagliptin Antidiabetic No Up Tight junction organization 0.006917983 6 NaN CGN;CLDN19;EMP1;MYLK
saxagliptin Antidiabetic No Down Tropoelastin synthesis 0.022318278 16 NaN ELN
saxagliptin Antidiabetic No Down WNT-Beta-catenin signaling pathway 0.013926759 10 NaN DACT1;DKK2;FRZB;WNT2;WNT9A
ruxolitinib Kinase inhibitor No Down Actin polymerization 0.026886169 16 NaN ACTA1;ENAH;FMNL2;GAS7
ruxolitinib Kinase inhibitor No Down Aggrecan synthesis 0.027258292 18 NaN ACAN
ruxolitinib Kinase inhibitor No Up Albumin mediated blood protein transport 0.018877911 14 NaN ALB
ruxolitinib Kinase inhibitor No Down Antigen presentation via MHC class I molecules 0.028842387 20.5 NaN HLA-B;HLA-C
ruxolitinib Kinase inhibitor No Down Aspartate and arginine metabolism 9.99E-05 2 NaN ARG2;ASS1;SLC7A1;SLC7A2
ruxolitinib Kinase inhibitor No Up Biglycan synthesis 0.018877911 14 NaN BGN
ruxolitinib Kinase inhibitor No Down CCN intercellular signaling protein family receptor signaling 0.007013572 8 NaN CTGF;NOV
ruxolitinib Kinase inhibitor No Up Centrosome maturation 0.001286823 6 NaN AURKA;PLK1;TPX2
ruxolitinib Kinase inhibitor No Up Centrosome separation 5.34E-07 2 NaN AURKA;CCNB1;CDK1;NEK2;SPAG5
ruxolitinib Kinase inhibitor No Down Chloride transmembrane transport 0.047387116 22.5 NaN ANO1;BEST1
ruxolitinib Kinase inhibitor No Up Cholesterol synthesis 2.82E-05 3 NaN DHCR24;FDFT1;FDPS;HMGCS1;MVK
ruxolitinib Kinase inhibitor No Up Collagen fibril organization by fibril-associated bridges 0.005061213 9 NaN COL14A1;COL9A1
ruxolitinib Kinase inhibitor No Down Collagen fibril organization by fibril-associated bridges 0.010331661 9.5 NaN COL12A1;COL9A2
ruxolitinib Kinase inhibitor No Down Connection of muscle sarcomere to plasma membrane 0.028842387 20.5 NaN DES;SYNM
ruxolitinib Kinase inhibitor No Up Decorin synthesis 0.018877911 14 NaN DCN
ruxolitinib Kinase inhibitor No Up Eukaryotic kinetochore dynamics 0.005514636 11 NaN BUB1;CENPE;CENPF;NUF2
ruxolitinib Kinase inhibitor No Up Extracellular matrix breakdown by matrix metalloproteases 0.000512369 5 NaN MMP12;MMP2;MMP3
ruxolitinib Kinase inhibitor No Up Fibrillar collagen core structure organization 8.32E-09 1 NaN COL11A2;COL1A1;COL1A2;COL2A1;COL3A1;COL5A1
ruxolitinib Kinase inhibitor No Up Fibulin receptor signaling 0.037401081 22.5 NaN FBLN1
ruxolitinib Kinase inhibitor No Down Filopodium organization 0.026579947 15 NaN ENAH;FMNL2;GAP43
ruxolitinib Kinase inhibitor No Up G2 M transition checkpoint 0.020669774 17.5 NaN CCNB1;CDK1
ruxolitinib Kinase inhibitor No Up GABA metabolism 0.005061213 9 NaN ABAT;SLC6A1
ruxolitinib Kinase inhibitor No Down Glutamate and glutamine metabolism 0.004682035 7 NaN SLC1A5;SLC38A2;SLC7A5
ruxolitinib Kinase inhibitor No Down Granulocyte-colony stimulating factor receptor signaling 0.023491402 14 NaN SOCS3;STAT3
ruxolitinib Kinase inhibitor No Down Hepatocyte growth factor receptor signaling 0.000740675 4 NaN HGF;MET
ruxolitinib Kinase inhibitor No Up Inhibition of apoptosis 0.020669774 17.5 NaN BIRC5;IFI6
ruxolitinib Kinase inhibitor No Down Leptin receptor signaling 0.004285177 5.5 NaN SOCS3;STAT3
ruxolitinib Kinase inhibitor No Up Lipogenesis 0.037401081 22.5 NaN FASN
ruxolitinib Kinase inhibitor No Up Metaphase to anaphase checkpoint 3.65E-05 4 NaN BUB1;BUB1B;CCNB2;CDC20;CENPE;PTTG1
ruxolitinib Kinase inhibitor No Up Microfibril scaffold organization 0.037401081 22.5 NaN FBN1
ruxolitinib Kinase inhibitor No Up Microtubule destabilization 0.005061213 9 NaN KIF2C;STMN1
ruxolitinib Kinase inhibitor No Up Mitotic spindle assembly 0.001649697 7 NaN DLGAP5;NUSAP1;TPX2
ruxolitinib Kinase inhibitor No Up Mitotic spindle disassembly 0.018877911 14 NaN CDK1
ruxolitinib Kinase inhibitor No Down Notch receptor signaling 0.01621364 12 NaN DLK1;LFNG;NOTCH3
ruxolitinib Kinase inhibitor No Down Osteonectin receptor signaling 0.004285177 5.5 NaN SMOC2;SPOCK1
ruxolitinib Kinase inhibitor No Up Osteopontin receptor signaling 0.018877911 14 NaN SPP1
ruxolitinib Kinase inhibitor No Down Progesterone receptor signaling 0.027258292 18 NaN PGR
ruxolitinib Kinase inhibitor No Down Retinoic acid receptor signaling 0.047387116 22.5 NaN NR4A1;TBL1XR1
ruxolitinib Kinase inhibitor No Up Retinol metabolism 0.024127969 19 NaN ALDH1A1;RDH10
ruxolitinib Kinase inhibitor No Down Sarcoplasmic reticulum organization 0.018602463 13 NaN PLN;TRDN
ruxolitinib Kinase inhibitor No Down Serine and glycine metabolism 0.000153557 3 NaN PHGDH;PSAT1;SHMT2;SLC1A5
ruxolitinib Kinase inhibitor No Up Sister chromatid attachment to mitotic spindle 0.037401081 22.5 NaN NUF2
ruxolitinib Kinase inhibitor No Down Thin myofilament organization 0.014205479 11 NaN ACTA1;TNNI3
ruxolitinib Kinase inhibitor No Down Tropoelastin synthesis 0.027258292 18 NaN ELN
ruxolitinib Kinase inhibitor No Down Urea cycle 0.010331661 9.5 NaN ARG2;ASS1
ruxolitinib Kinase inhibitor No Up WNT-Beta-catenin signaling pathway 0.03254987 20 NaN APCDD1;FRZB;SFRP2;SFRP5
ruxolitinib Kinase inhibitor No Down Z-disc organization 4.97E-05 1 NaN CSRP3;DES;LDB3;PDLIM3;TCAP
rosiglitazone Antidiabetic No Down Adherens junction organization 0.007969333 8 NaN CDH1;CDH3;CGNL1;MYO1D
rosiglitazone Antidiabetic No Down Albumin mediated blood protein transport 0.019407198 14.5 NaN ALB
rosiglitazone Antidiabetic No Up Alternative complement pathway 0.00628096 8 NaN C3;CFH
rosiglitazone Antidiabetic No Down Amyloid plaque organization 0.018374809 11.5 NaN COL25A1;HSPB6
rosiglitazone Antidiabetic No Up Aspartate and arginine metabolism 0.025958406 19 NaN ARG2;DDAH1
rosiglitazone Antidiabetic No Down Biglycan synthesis 0.019407198 14.5 NaN BGN
rosiglitazone Antidiabetic No Down Cellular cholesterol uptake and efflux 0.0254047 17 NaN ABCA1;ABCG1
rosiglitazone Antidiabetic No Up Cellular iron uptake and export 0.042773869 21 NaN CP;TFRC
rosiglitazone Antidiabetic No Up Collagen fiber crosslinking 0.00628096 8 NaN LOXL1;PXDN
rosiglitazone Antidiabetic No Down Collagen fibril organization by fibril-associated bridges 0.005342076 4 NaN COL12A1;COL14A1
rosiglitazone Antidiabetic No Up Decorin synthesis 0.025758645 17.5 NaN DCN
rosiglitazone Antidiabetic No Up DNA replication initiation 0.0255927 16 NaN CDC45;CDC6;MCM5
rosiglitazone Antidiabetic No Up Endogenous control of complement activity 0.00628096 8 NaN CFH;CFI
rosiglitazone Antidiabetic No Down Endothelin receptor signaling 0.007383606 6.5 NaN ECE1;EDN1
rosiglitazone Antidiabetic No Up Extracellular matrix breakdown and membrane shedding by adamalysins 2.53E-05 1 NaN ADAM19;ADAM33;ADAMTS1;ADAMTS2;ADAMTS5;ADAMTS9
rosiglitazone Antidiabetic No Down Extracellular matrix breakdown by cathepsins 0.000782324 1 NaN CTSB;CTSF;CTSZ
rosiglitazone Antidiabetic No Down Extracellular matrix breakdown by serine proteases 0.007383606 6.5 NaN KLK5;PRSS12
rosiglitazone Antidiabetic No Up Fibrillar collagen core structure organization 0.001774618 4 NaN COL11A2;COL1A2;COL3A1
rosiglitazone Antidiabetic No Down Fibrillar collagen core structure organization 0.015226725 10 NaN COL1A1;COL5A2
rosiglitazone Antidiabetic No Down GABA metabolism 0.005342076 4 NaN ABAT;SLC6A1
rosiglitazone Antidiabetic No Up Gap junction organization 0.04907168 23 NaN GJA5;GJA8
rosiglitazone Antidiabetic No Up Glutamate and glutamine metabolism 0.042773869 21 NaN SLC1A5;SLC7A5
rosiglitazone Antidiabetic No Up Glycolysis and Gluconeogenesis 0.020461275 14 NaN ENO1;HK2;PCK2
rosiglitazone Antidiabetic No Up Granulocyte-colony stimulating factor receptor signaling 0.021121648 15 NaN SOCS3;STAT3
rosiglitazone Antidiabetic No Down Growth differentiation factor receptor signaling 0.009719559 9 NaN GDF2;GDF6
rosiglitazone Antidiabetic No Up Inhibin receptor signaling 0.000860536 3 NaN INHBB;INHBE;TGFBR3
rosiglitazone Antidiabetic No Up Interferon alpha receptor signaling 0.016709342 13 NaN IRF9;STAT1
rosiglitazone Antidiabetic No Up JAK-STAT signaling pathway 0.000351975 2 NaN SOCS2;SOCS3;STAT1;STAT3
rosiglitazone Antidiabetic No Up Leptin receptor signaling 0.003833695 6 NaN SOCS3;STAT3
rosiglitazone Antidiabetic No Down Microfibril scaffold organization 0.038439436 19.5 NaN FBN1
rosiglitazone Antidiabetic No Up Mitotic chromosome condensation 0.01274714 11 NaN INCENP;NCAPG2
rosiglitazone Antidiabetic No Up Natriuretic peptide receptor signaling 0.009261749 10 NaN NPPA;NPPB
rosiglitazone Antidiabetic No Up Notch receptor signaling 0.013937761 12 NaN DLK1;LFNG;NOTCH3
rosiglitazone Antidiabetic No Down Osteopontin receptor signaling 0.019407198 14.5 NaN SPP1
rosiglitazone Antidiabetic No Down Platelet-derived growth factor receptor signaling 0.018374809 11.5 NaN PDGFRA;TNK2
rosiglitazone Antidiabetic No Down Prostaglandin PGF2 alpha receptor signaling 0.038439436 19.5 NaN PTGFR
rosiglitazone Antidiabetic No Down Removal of caspase inhibition 0.038439436 19.5 NaN XAF1
rosiglitazone Antidiabetic No Up Retinol metabolism 0.042773869 21 NaN DHRS3;RLBP1
rosiglitazone Antidiabetic No Down Selectin-mediated Leukocyte rolling 0.005342076 4 NaN SELP;VCAM1
rosiglitazone Antidiabetic No Up Serine and glycine metabolism 0.002393839 5 NaN GLDC;PSAT1;SLC1A5
rosiglitazone Antidiabetic No Down Thrombospondin receptor signaling 0.00219248 2 NaN THBS2;THBS4
rosiglitazone Antidiabetic No Up Tropoelastin synthesis 0.025758645 17.5 NaN ELN
rosiglitazone Antidiabetic No Down Versican receptor signaling 0.038439436 19.5 NaN VCAN
rosiglitazone Antidiabetic No Down Versican synthesis 0.019407198 14.5 NaN VCAN
rituximab Monoclonal antibody No Down Adrenergic receptor signaling 0.019352519 8 NaN ADCY2;RAPGEF4;RGS4
rituximab Monoclonal antibody No Down Aggrecan synthesis 0.022230064 11 NaN ACAN
rituximab Monoclonal antibody No Up Antigen presentation via MHC class I molecules 0.019397192 8 NaN HLA-B;HLA-C
rituximab Monoclonal antibody No Up Basement membrane assembly and organization 0.019397192 8 NaN COL4A4;HSPG2
rituximab Monoclonal antibody No Up Biglycan synthesis 0.022053634 11 NaN BGN
rituximab Monoclonal antibody No Up Cardiomyocyte repolarization during action potential and hyperpolarization 0.037023918 16 NaN KCNIP2;KCNJ2
rituximab Monoclonal antibody No Down Cardiomyocyte repolarization during action potential and hyperpolarization 0.037567125 14 NaN KCNA1;KCNQ1
rituximab Monoclonal antibody No Down CCN intercellular signaling protein family receptor signaling 0.000105033 1 NaN CTGF;NOV;WISP1
rituximab Monoclonal antibody No Down Cellular cholesterol uptake and efflux 0.032671153 13 NaN ABCA1;ABCG1
rituximab Monoclonal antibody No Down Cholesterol-sensitive control of SREBP activation 0.006960163 5.5 NaN INSIG1;SREBF1
rituximab Monoclonal antibody No Up Collagen fibril organization by fibril-associated bridges 0.000201793 4 NaN COL9A1;COL9A2;COL9A3
rituximab Monoclonal antibody No Down Decorin synthesis 0.022230064 11 NaN DCN
rituximab Monoclonal antibody No Down Electron transport chain 0.002058279 4 NaN COX7A1;NDUFS4;NDUFV2
rituximab Monoclonal antibody No Up Epithelial intermediate filament dynamics 0.012425035 6 NaN KRT19;KRT4
rituximab Monoclonal antibody No Up Extracellular matrix breakdown and membrane shedding by adamalysins 1.04E-05 1 NaN ADAM15;ADAMTS1;ADAMTS12;ADAMTS14;ADAMTS17;ADAMTS9
rituximab Monoclonal antibody No Up Extracellular matrix breakdown by cathepsins 0.019397192 8 NaN CTSD;CTSV
rituximab Monoclonal antibody No Up Extracellular matrix breakdown by matrix metalloproteases 2.67E-05 2 NaN MMP12;MMP14;MMP2;MMP3
rituximab Monoclonal antibody No Up Fibrillar collagen core structure organization 4.37E-05 3 NaN COL11A2;COL2A1;COL3A1;COL5A2
rituximab Monoclonal antibody No Down Fibrillar collagen core structure organization 0.019690847 9 NaN COL11A1;COL1A2
rituximab Monoclonal antibody No Down Glucuronidation 0.022230064 11 NaN UGT2B4
rituximab Monoclonal antibody No Up Glutamate and glutamine metabolism 0.032195057 14.5 NaN SLC1A5;SLC7A5
rituximab Monoclonal antibody No Down Glycolysis and Gluconeogenesis 0.0015134 2 NaN LDHA;PCK2;PGK1;TPI1
rituximab Monoclonal antibody No Down Hepatocyte growth factor receptor signaling 0.043967869 16.5 NaN MET
rituximab Monoclonal antibody No Up Lipogenesis 0.043622809 18 NaN FASN
rituximab Monoclonal antibody No Down Microfibril scaffold organization 0.043967869 16.5 NaN FBN1
rituximab Monoclonal antibody No Down Microtubule polymerization 0.006960163 5.5 NaN DCLK1;TUBA1A
rituximab Monoclonal antibody No Up Perlecan synthesis 0.022053634 11 NaN HSPG2
rituximab Monoclonal antibody No Up Platelet-derived growth factor receptor signaling 0.023366841 13 NaN FOSL1;TNK2
rituximab Monoclonal antibody No Down Removal of caspase inhibition 0.043967869 16.5 NaN XAF1
rituximab Monoclonal antibody No Up Retinol metabolism 0.032195057 14.5 NaN ALDH1A2;STRA6
rituximab Monoclonal antibody No Up Semaphorin signaling 0.038375695 17 NaN CRMP1;PLXNA4;PLXND1
rituximab Monoclonal antibody No Down Serine and glycine metabolism 0.00156935 3 NaN PHGDH;SHMT2;SLC1A4
rituximab Monoclonal antibody No Down Serotonin inactivation 0.043967869 16.5 NaN MAOA
rituximab Monoclonal antibody No Up Sulfonation 0.004636036 5 NaN SULT1A1;SULT1E1
rituximab Monoclonal antibody No Down Transamination pathways 0.009601976 7 NaN BCAT1;GOT1
rituximab Monoclonal antibody No Up Tropoelastin synthesis 0.022053634 11 NaN ELN
rituximab Monoclonal antibody No Down Z-disc organization 0.048125749 19 NaN CSRP3;TCAP
regorafenib Kinase inhibitor No Up Aggrecan synthesis 0.024964714 24 NaN ACAN
regorafenib Kinase inhibitor No Down Antigen presentation via MHC class I molecules 0.017535602 7.5 NaN HLA-B;HLA-C
regorafenib Kinase inhibitor No Up Centrosome maturation 0.002865155 11 NaN AURKA;PLK1;TPX2
regorafenib Kinase inhibitor No Up Centrosome separation 6.32E-10 2 NaN AURKA;CCNB1;CDK1;ESPL1;KIF11;NEK2;SPAG5
regorafenib Kinase inhibitor No Up Chaperone-mediated autophagy 0.049308339 30 NaN HSPA8
regorafenib Kinase inhibitor No Up Cholesterol synthesis 4.90E-15 1 NaN CYP51A1;DHCR24;DHCR7;FDFT1;FDPS;HMGCR;HMGCS1;LSS;MSMO1;MVD;NSDHL;SQLE
regorafenib Kinase inhibitor No Up Collagen fibril organization by fibril-associated bridges 0.0087173 17 NaN COL9A2;COL9A3
regorafenib Kinase inhibitor No Up Contractile ring constriction 0.000148334 6 NaN ANLN;ECT2;MYH14
regorafenib Kinase inhibitor No Up Contractile ring formation 0.005908595 14.5 NaN MYH14;RACGAP1
regorafenib Kinase inhibitor No Up Decorin synthesis 0.024964714 24 NaN DCN
regorafenib Kinase inhibitor No Up Desaturation of fatty acids 0.012004155 19.5 NaN FADS2;SCD
regorafenib Kinase inhibitor No Up Equatorial RhoA activation 0.003604491 12.5 NaN ECT2;KIF23
regorafenib Kinase inhibitor No Down ER unfolded protein response pathway 0.011215577 6 NaN ATF4;HERPUD1
regorafenib Kinase inhibitor No Up Eukaryotic kinetochore dynamics 3.49E-06 3 NaN BUB1;CENPE;CENPF;MTUS2;NDC80;NUF2;SPC24;TTK
regorafenib Kinase inhibitor No Up Extracellular matrix breakdown and membrane shedding by adamalysins 0.021145298 21 NaN ADAM33;ADAMTS15;ADAMTS2
regorafenib Kinase inhibitor No Up Fibrillar collagen core structure organization 7.09E-05 5 NaN COL11A1;COL2A1;COL5A1;COL5A2
regorafenib Kinase inhibitor No Down Fibrillar collagen core structure organization 0.000971271 2 NaN COL1A1;COL1A2;COL3A1
regorafenib Kinase inhibitor No Up G2 M transition checkpoint 0.034752905 27 NaN CCNB1;CDK1
regorafenib Kinase inhibitor No Down Gap junction organization 0.033571046 12 NaN GJA3;GJA5
regorafenib Kinase inhibitor No Down Glutamate and glutamine metabolism 0.029170805 10.5 NaN SLC38A2;SLC7A5
regorafenib Kinase inhibitor No Up Hyaluronan-mediated motility receptor signaling 0.024964714 24 NaN HMMR
regorafenib Kinase inhibitor No Up Lipogenesis 0.049308339 30 NaN FASN
regorafenib Kinase inhibitor No Up MAPK signaling pathway 0.038039913 28 NaN FOXM1;MAP2K3;MAP2K6
regorafenib Kinase inhibitor No Up Metaphase to anaphase checkpoint 1.69E-05 4 NaN BUB1;BUB1B;CCNB2;CDC20;CENPE;PTTG1;TTK
regorafenib Kinase inhibitor No Down Methionine cycle 0.041378401 14.5 NaN BHMT
regorafenib Kinase inhibitor No Up Microtubule destabilization 0.0087173 17 NaN KIF2C;STMN1
regorafenib Kinase inhibitor No Up Mitotic H3 phosphorylation and dephosphorylation 0.005908595 14.5 NaN AURKB;CCNA2
regorafenib Kinase inhibitor No Up Mitotic spindle assembly 0.000227554 7 NaN DLGAP5;NUSAP1;TPX2;TTK
regorafenib Kinase inhibitor No Up Mitotic spindle disassembly 0.024964714 24 NaN CDK1
regorafenib Kinase inhibitor No Up Muscarinic receptor signaling 0.0087173 17 NaN CHRM4;RGS5
regorafenib Kinase inhibitor No Down Myofibril formation 0.017535602 7.5 NaN DES;MYOZ1
regorafenib Kinase inhibitor No Down Natriuretic peptide receptor signaling 0.006176635 5 NaN NPPA;NPPB
regorafenib Kinase inhibitor No Down Osteonectin receptor signaling 0.002540098 4 NaN SPARC;SPOCK1
regorafenib Kinase inhibitor No Up Osteopontin receptor signaling 0.024964714 24 NaN SPP1
regorafenib Kinase inhibitor No Up Platelet-derived growth factor receptor signaling 0.002189037 10 NaN PDGFRA;PDGFRB;RGS5
regorafenib Kinase inhibitor No Up Polyol pathway 0.003604491 12.5 NaN AKR1A1;SORD
regorafenib Kinase inhibitor No Down Prostaglandin PGF2 alpha receptor signaling 0.041378401 14.5 NaN PTGFR
regorafenib Kinase inhibitor No Up Proteasomal regulatory particle organization 0.012004155 19.5 NaN PSMC4;PSMD14
regorafenib Kinase inhibitor No Down Retinol metabolism 0.029170805 10.5 NaN RDH10;STRA6
regorafenib Kinase inhibitor No Down Serine and glycine metabolism 0.001314959 3 NaN PHGDH;PSAT1;SHMT2
regorafenib Kinase inhibitor No Down Serotonin inactivation 0.041378401 14.5 NaN MAOA
regorafenib Kinase inhibitor No Up Sister chromatid attachment to mitotic spindle 0.049308339 30 NaN NUF2
regorafenib Kinase inhibitor No Up Sister chromatid segregation 0.000291184 8 NaN ESPL1;PTTG1;TOP2A
regorafenib Kinase inhibitor No Down Tropoelastin synthesis 0.020906845 9 NaN ELN
regorafenib Kinase inhibitor No Down Vasoactive intestinal peptide receptor signaling 0.041378401 14.5 NaN VIPR1
regorafenib Kinase inhibitor No Up WNT-Beta-catenin signaling pathway 0.001032546 9 NaN APCDD1;CTHRC1;DKK2;FRZB;SFRP4;SFRP5;WNT2
regorafenib Kinase inhibitor No Down Z-disc organization 0.000278145 1 NaN CSRP3;DES;MYOZ1;PDLIM3
prednisolone Glucocorticoid Yes Up Albumin mediated blood protein transport 0.018966126 5 NaN ALB
prednisolone Glucocorticoid Yes Down Base excision repair 0.007309952 22 NaN FEN1;NEIL3;PCNA;POLQ
prednisolone Glucocorticoid Yes Up Cardiomyocyte repolarization during action potential and hyperpolarization 0.028045575 7 NaN KCNJ12;KCNJ2
prednisolone Glucocorticoid Yes Down CCN intercellular signaling protein family receptor signaling 0.00741681 23.5 NaN CTGF;CYR61
prednisolone Glucocorticoid Yes Up Cellular iron uptake and export 0.024338824 6 NaN RASD1;SLC39A14
prednisolone Glucocorticoid Yes Down Centrosome maturation 0.003985148 19 NaN AURKA;PLK1;TPX2
prednisolone Glucocorticoid Yes Down Centrosome organization 0.011839456 29 NaN ASPM;NEK2;PLK4;POC1A;TACC3;WDR62
prednisolone Glucocorticoid Yes Down Centrosome separation 1.43E-09 3 NaN AURKA;CCNB1;CDK1;ESPL1;KIF11;NEK2;SPAG5
prednisolone Glucocorticoid Yes Up Class switch recombination 0.049549457 11 NaN BCL6;IRF8
prednisolone Glucocorticoid Yes Down Collagen fibril organization by fibril-associated bridges 0.010919862 27 NaN COL14A1;COL9A1
prednisolone Glucocorticoid Yes Down Contractile ring constriction 0.00741681 23.5 NaN ANLN;ECT2
prednisolone Glucocorticoid Yes Down DNA replication elongation 1.68E-08 4 NaN MCM2;MCM4;MCM5;MCM7;PCNA
prednisolone Glucocorticoid Yes Down DNA replication initiation 4.75E-16 1 NaN CDC45;CDC6;GINS1;GINS2;GINS4;MCM10;MCM2;MCM3;MCM4;MCM5;MCM6;MCM7;ORC6;TICRR
prednisolone Glucocorticoid Yes Down Equatorial RhoA activation 0.004533971 20.5 NaN ECT2;KIF23
prednisolone Glucocorticoid Yes Down Eukaryotic kinetochore dynamics 7.41E-13 2 NaN BUB1;CENPE;CENPF;CENPH;CENPI;CENPU;KIF15;MAD2L1;NDC80;NUF2;SKA3;SPC24;TTK;ZWINT
prednisolone Glucocorticoid Yes Down Fanconi anemia interstrand cross-link repair pathway 5.32E-06 8 NaN BRCA2;BRIP1;FANCA;FANCD2;FANCG;FANCI;UBE2T
prednisolone Glucocorticoid Yes Down Fibrillar collagen core structure organization 3.78E-06 7 NaN COL1A1;COL1A2;COL2A1;COL3A1;COL5A2
prednisolone Glucocorticoid Yes Down G2 M transition checkpoint 0.000251674 12 NaN CCNB1;CDC25C;CDK1;CHEK2
prednisolone Glucocorticoid Yes Up Glycogen synthesis and glycogenolysis 0.036079961 9 NaN AGL;PPP1R3B
prednisolone Glucocorticoid Yes Up HIF-1 receptor signaling pathway 0.000519411 1 NaN EGLN1;EGLN3;HIF1A
prednisolone Glucocorticoid Yes Down Homologous recombination DSB repair 0.000267364 13 NaN BRCA2;EXO1;PIF1;RAD51AP1;RECQL4;RMI2;XRCC2
prednisolone Glucocorticoid Yes Down Intracellular bridge assembly 0.002309819 17.5 NaN INCENP;KIF23
prednisolone Glucocorticoid Yes Up Lipid droplet biogenesis 0.000731661 2 NaN FITM2;PLIN2;PLIN5
prednisolone Glucocorticoid Yes Down Metaphase to anaphase checkpoint 2.72E-07 5 NaN BUB1;BUB1B;CCNB2;CDC20;CENPE;MAD2L1;MXD3;PTTG1;TTK
prednisolone Glucocorticoid Yes Down Microtubule destabilization 0.010919862 27 NaN KIF2C;STMN1
prednisolone Glucocorticoid Yes Down Mitotic chromosome condensation 1.99E-05 9 NaN INCENP;NCAPG2;SMC2;SMC4
prednisolone Glucocorticoid Yes Down Mitotic H3 phosphorylation and dephosphorylation 0.000209712 11 NaN AURKB;CCNA2;INCENP
prednisolone Glucocorticoid Yes Down Mitotic spindle assembly 6.76E-07 6 NaN CKAP2;DLGAP5;NUSAP1;TACC3;TPX2;TTK
prednisolone Glucocorticoid Yes Up Natriuretic peptide receptor signaling 0.005107525 3 NaN NPPA;NPPB
prednisolone Glucocorticoid Yes Down Notch receptor signaling 0.017499293 30 NaN DLK1;JAG1;NOTCH3
prednisolone Glucocorticoid Yes Down Nuclear envelope maintenance 0.010919862 27 NaN LMNB1;TMPO
prednisolone Glucocorticoid Yes Down Nuclear intermediate filaments 0.000410704 14.5 NaN LMNB1;LMNB2;TMPO
prednisolone Glucocorticoid Yes Down Osteonectin receptor signaling 0.004533971 20.5 NaN SPARC;SPOCK1
prednisolone Glucocorticoid Yes Down Ribonucleotide reduction 0.002309819 17.5 NaN RRM1;RRM2
prednisolone Glucocorticoid Yes Up Serotonin inactivation 0.037574179 10 NaN MAOA
prednisolone Glucocorticoid Yes Down Sister chromatid attachment to mitotic spindle 0.000784522 16 NaN NUF2;TACC3
prednisolone Glucocorticoid Yes Down Sister chromatid segregation 0.000410704 14.5 NaN ESPL1;PTTG1;TOP2A
prednisolone Glucocorticoid Yes Down Telomere replication and maintenance 0.00933578 25 NaN EXO1;PIF1;RECQL4
prednisolone Glucocorticoid Yes Down Thrombospondin receptor signaling 8.57E-05 10 NaN CD47;THBS1;THBS2
prednisolone Glucocorticoid Yes Up Water transmembrane transport 0.009298267 4 NaN AQP1;AQP10
prednisolone Glucocorticoid Yes Up WNT-Beta-catenin signaling pathway 0.033030217 8 NaN AXIN2;DKK3;SFRP5;WNT9A
ponatinib Kinase inhibitor Yes Down Adrenergic receptor signaling 0.026192093 14 8 Down by cardiotoxic TKIs RASD1;RGS16;RGS4
ponatinib Kinase inhibitor Yes Up Albumin mediated blood protein transport 0.021436133 18 NaN ALB
ponatinib Kinase inhibitor Yes Down Biglycan synthesis 0.024964714 12.5 18 Down by cardiotoxic TKIs BGN
ponatinib Kinase inhibitor Yes Down Cardiomyocyte pacemaker current generation 0.000785504 4 NaN CACNA1D;CACNA1G;HCN4
ponatinib Kinase inhibitor Yes Down CCN intercellular signaling protein family receptor signaling 0.005908595 6 NaN CTGF;CYR61
ponatinib Kinase inhibitor Yes Up Centrosome maturation 0.001854703 10.5 NaN AURKA;PLK1;TPX2
ponatinib Kinase inhibitor Yes Up Centrosome separation 2.17E-10 1 NaN AURKA;CCNB1;CDK1;ESPL1;KIF11;NEK2;SPAG5
ponatinib Kinase inhibitor Yes Down Chloride transmembrane transport 0.003656435 5 17 Down by cardiotoxic TKIs ANO1;SLC12A6;SLC12A7
ponatinib Kinase inhibitor Yes Up Contractile ring constriction 0.004385018 14 NaN ANLN;ECT2
ponatinib Kinase inhibitor Yes Up Decorin synthesis 0.021436133 18 NaN DCN
ponatinib Kinase inhibitor Yes Up Equatorial RhoA activation 0.00266871 12.5 NaN ECT2;KIF23
ponatinib Kinase inhibitor Yes Up Eukaryotic kinetochore dynamics 1.11E-06 4 NaN BUB1;CENPE;CENPF;KNSTRN;MAD2L1;NDC80;NUF2;TTK
ponatinib Kinase inhibitor Yes Down Extracellular matrix breakdown by matrix metalloproteases 0.019911463 9 NaN MMP14;MMP3
ponatinib Kinase inhibitor Yes Down Fibrillar collagen core structure organization 0.024483872 10.5 NaN COL1A1;COL1A2
ponatinib Kinase inhibitor Yes Up G2 M transition checkpoint 0.001854703 10.5 NaN CCNB1;CDC25C;CDK1
ponatinib Kinase inhibitor Yes Down Gap junction organization 0.046379866 15 24 Down by cardiotoxic TKIs GJA5;GJB2
ponatinib Kinase inhibitor Yes Down Growth differentiation factor receptor signaling 0.015743705 8 NaN GDF11;GDF6
ponatinib Kinase inhibitor Yes Up Hyaluronan-mediated motility receptor signaling 0.021436133 18 NaN HMMR
ponatinib Kinase inhibitor Yes Up Inhibition of apoptosis 0.026216245 21 NaN BIRC5;IFI6
ponatinib Kinase inhibitor Yes Up Intracellular bridge assembly 0.001353509 8 NaN INCENP;KIF23
ponatinib Kinase inhibitor Yes Up Metaphase to anaphase checkpoint 4.46E-07 3 NaN BUB1;BUB1B;CCNB2;CDC20;CENPE;MAD2L1;PTTG1;TTK
ponatinib Kinase inhibitor Yes Up Methionine cycle 0.042414608 22.5 NaN BHMT
ponatinib Kinase inhibitor Yes Down Microfibril scaffold organization 0.049308339 16 NaN FBN1
ponatinib Kinase inhibitor Yes Up Mitotic chromosome condensation 0.008950881 15 NaN INCENP;SMC4
ponatinib Kinase inhibitor Yes Up Mitotic H3 phosphorylation and dephosphorylation 9.42E-05 5 NaN AURKB;CCNA2;INCENP
ponatinib Kinase inhibitor Yes Up Mitotic spindle assembly 1.38E-07 2 NaN CKAP2;DLGAP5;NUSAP1;TACC3;TPX2;TTK
ponatinib Kinase inhibitor Yes Up Mitotic spindle disassembly 0.021436133 18 NaN CDK1
ponatinib Kinase inhibitor Yes Down Muscarinic receptor signaling 0.0087173 7 NaN CHRM4;RGS4
ponatinib Kinase inhibitor Yes Down Myofibril formation 0.024483872 10.5 6 Down by cardiotoxic TKIs KLHL41;XIRP1
ponatinib Kinase inhibitor Yes Up Osteonectin receptor signaling 0.00266871 12.5 NaN SMOC2;SPOCK1
ponatinib Kinase inhibitor Yes Down Platelet-derived growth factor receptor signaling 0.000109262 2 14 Down by cardiotoxic TKIs FOSL1;PDGFB;PDGFRA;PDGFRB
ponatinib Kinase inhibitor Yes Up Protein polyubiquitination 0.04507252 24 NaN ISG15;UCHL1
ponatinib Kinase inhibitor Yes Up Serine and glycine metabolism 0.001413291 9 19 Up by cardiotoxic TKIs PHGDH;PSAT1;SHMT2
ponatinib Kinase inhibitor Yes Up Sister chromatid attachment to mitotic spindle 0.000457657 7 NaN NUF2;TACC3
ponatinib Kinase inhibitor Yes Up Sister chromatid segregation 0.000185509 6 NaN ESPL1;PTTG1;TOP2A
ponatinib Kinase inhibitor Yes Down Thin myofilament organization 1.25E-05 1 21 Down by cardiotoxic TKIs ACTA1;LMOD3;TNNI3;TPM2
ponatinib Kinase inhibitor Yes Down Tropoelastin synthesis 0.024964714 12.5 NaN ELN
ponatinib Kinase inhibitor Yes Up Versican receptor signaling 0.042414608 22.5 NaN VCAN
ponatinib Kinase inhibitor Yes Up Versican synthesis 0.021436133 18 NaN VCAN
ponatinib Kinase inhibitor Yes Down Z-disc organization 0.000545929 3 NaN CSRP3;MYPN;PDLIM3;TCAP
pioglitazone Antidiabetic No Down Aggrecan synthesis 0.023553282 13.5 NaN ACAN
pioglitazone Antidiabetic No Up Albumin mediated blood protein transport 0.020906845 13 NaN ALB
pioglitazone Antidiabetic No Up Axonal intermediate filament dynamics 0.00852857 7.5 NaN NEFH;NES
pioglitazone Antidiabetic No Down Basement membrane assembly and organization 0.02195395 10 NaN COL8A2;HSPG2
pioglitazone Antidiabetic No Up Biglycan synthesis 0.020906845 13 NaN BGN
pioglitazone Antidiabetic No Down CCN intercellular signaling protein family receptor signaling 0.005273302 5.5 NaN CTGF;CYR61
pioglitazone Antidiabetic No Down Cellular cholesterol uptake and efflux 0.036331775 18.5 NaN ARL4C;SCARA3
pioglitazone Antidiabetic No Up Cholesterol-sensitive control of SREBP activation 0.006176635 5.5 NaN INSIG1;SREBF1
pioglitazone Antidiabetic No Down Classical complement pathway 9.96E-06 1 NaN C1QA;C1QB;C1QC;C1R
pioglitazone Antidiabetic No Down Collagen fibril organization by fibril-associated bridges 0.007787369 7.5 NaN COL12A1;COL14A1
pioglitazone Antidiabetic No Down Decorin synthesis 0.023553282 13.5 NaN DCN
pioglitazone Antidiabetic No Down Extracellular matrix breakdown and membrane shedding by adamalysins 0.018142498 9 NaN ADAM19;ADAMTS1;ADAMTS8
pioglitazone Antidiabetic No Up Extracellular matrix breakdown by matrix metalloproteases 0.014222736 9 NaN MMP1;MMP2
pioglitazone Antidiabetic No Up Fibrillar collagen core structure organization 0.017535602 10.5 NaN COL1A1;COL5A1
pioglitazone Antidiabetic No Down Fibrillar collagen core structure organization 5.65E-05 3 NaN COL11A1;COL1A2;COL2A1;COL3A1
pioglitazone Antidiabetic No Down Glutamate and glutamine metabolism 0.0031016 4 NaN SLC1A5;SLC38A2;SLC7A5
pioglitazone Antidiabetic No Down Granulocyte macrophage colony-stimulating factor receptor signaling 0.046553835 22 NaN JUND
pioglitazone Antidiabetic No Down Hepatocyte growth factor receptor signaling 0.046553835 22 NaN HGF
pioglitazone Antidiabetic No Up Inhibition of amyloid aggregation, amyloid degradation and uptake 0.00128782 1 NaN A2M;PLAT
pioglitazone Antidiabetic No Down Macrophage migration inhibitory factor signaling 0.005273302 5.5 NaN ACKR3;JUND
pioglitazone Antidiabetic No Up Microfibril scaffold organization 0.041378401 16.5 NaN FBN1
pioglitazone Antidiabetic No Up Myofibril formation 0.017535602 10.5 NaN DES;KLHL41
pioglitazone Antidiabetic No Down Natriuretic peptide receptor signaling 0.007787369 7.5 NaN NPPB;NPR3
pioglitazone Antidiabetic No Down Osteonectin receptor signaling 5.08E-05 2 NaN SMOC2;SPARC;SPOCK1
pioglitazone Antidiabetic No Up Osteopontin receptor signaling 0.020906845 13 NaN SPP1
pioglitazone Antidiabetic No Down Perlecan synthesis 0.023553282 13.5 NaN HSPG2
pioglitazone Antidiabetic No Up Platelet-derived growth factor receptor signaling 0.02114019 15 NaN PDGFRA;PDGFRB
pioglitazone Antidiabetic No Down Progesterone receptor signaling 0.023553282 13.5 NaN PGR
pioglitazone Antidiabetic No Up Prostaglandin E2 receptor signaling 0.006176635 5.5 NaN PTGER3;RAPGEF4
pioglitazone Antidiabetic No Down Removal of caspase inhibition 0.046553835 22 NaN XAF1
pioglitazone Antidiabetic No Down Retinoic acid receptor signaling 0.036331775 18.5 NaN NCOR2;NR4A1
pioglitazone Antidiabetic No Up Retinol metabolism 0.002209804 2 NaN ALDH1A1;RBP1;STRA6
pioglitazone Antidiabetic No Down Serine and glycine metabolism 0.026420838 17 NaN SHMT2;SLC1A5
pioglitazone Antidiabetic No Down Serotonin inactivation 0.046553835 22 NaN MAOA
pioglitazone Antidiabetic No Up Sulfonation 0.004175176 4 NaN SULT1A1;SULT1E1
pioglitazone Antidiabetic No Up Thin myofilament organization 0.00852857 7.5 NaN ACTA1;TNNI3
pioglitazone Antidiabetic No Up Thrombospondin receptor signaling 0.002540098 3 NaN THBS1;THBS2
pioglitazone Antidiabetic No Down Tropoelastin synthesis 0.023553282 13.5 NaN ELN
pioglitazone Antidiabetic No Up Vasoactive intestinal peptide receptor signaling 0.041378401 16.5 NaN VIPR1
pioglitazone Antidiabetic No Down Versican receptor signaling 0.046553835 22 NaN VCAN
pioglitazone Antidiabetic No Down Versican synthesis 0.023553282 13.5 NaN VCAN
pioglitazone Antidiabetic No Up Z-disc organization 0.043080025 18 NaN DES;TCAP
phenylephrine Sympathomimetic No Up Actin filament bundling and crosslinking 0.003732001 3 NaN FLNA;FLNB;TAGLN;USH1C
phenylephrine Sympathomimetic No Up Actin polymerization 0.020461081 8 NaN ACTA1;CYFIP2;FMNL2;HSPB1
phenylephrine Sympathomimetic No Down Adenylyl cyclase signaling pathway 0.046780829 17 NaN ADCY3;PDE3A
phenylephrine Sympathomimetic No Up Adrenergic receptor signaling 0.02643188 13 NaN PPP1R9B;RASD1;RGS4
phenylephrine Sympathomimetic No Down Albumin mediated blood protein transport 0.019407198 10.5 NaN ALB
phenylephrine Sympathomimetic No Up Amyloid plaque organization 0.029631379 14.5 NaN COL25A1;HSPB6
phenylephrine Sympathomimetic No Down Antigen presentation via MHC class I molecules 0.015226725 7 NaN HLA-B;HLA-C
phenylephrine Sympathomimetic No Up Biglycan synthesis 0.025052929 11 NaN BGN
phenylephrine Sympathomimetic No Up Calcium transmembrane transport 0.023812663 9 NaN ATP2B4;SLC8A1;TRPC4
phenylephrine Sympathomimetic No Up Cardiomyocyte depolarization during action potential 0.025052929 11 NaN SCN5A
phenylephrine Sympathomimetic No Down Centrosome separation 0.000782324 2.5 NaN CDK1;ESPL1;KIF11
phenylephrine Sympathomimetic No Up Chaperone-mediated autophagy 0.049480363 18.5 NaN HSPA8
phenylephrine Sympathomimetic No Down Collagen fibril organization by fibril-associated bridges 0.005342076 6 NaN COL9A1;COL9A3
phenylephrine Sympathomimetic No Down Decorin synthesis 0.019407198 10.5 NaN DCN
phenylephrine Sympathomimetic No Down Fibrillar collagen core structure organization 0.000782324 2.5 NaN COL1A1;COL1A2;COL3A1
phenylephrine Sympathomimetic No Up Glutamate and glutamine metabolism 0.04066719 16 NaN SLC1A3;SLC7A5
phenylephrine Sympathomimetic No Down Inhibition of apoptosis 0.021771043 13 NaN BIRC5;XAF1
phenylephrine Sympathomimetic No Up JAK-STAT signaling pathway 0.046676079 17 NaN SOCS2;STAT4
phenylephrine Sympathomimetic No Up Microfibril scaffold organization 0.049480363 18.5 NaN FBN1
phenylephrine Sympathomimetic No Down Mitotic spindle disassembly 0.019407198 10.5 NaN CDK1
phenylephrine Sympathomimetic No Up Natriuretic peptide receptor signaling 0.008777038 5 NaN NPPA;NPPB
phenylephrine Sympathomimetic No Up Nodal growth differentiation factor receptor signaling 0.004613854 4 NaN LEFTY2;NCLN;TGIF1
phenylephrine Sympathomimetic No Up Notch receptor signaling 0.012935202 6 NaN JAG2;NOTCH1;NOTCH3
phenylephrine Sympathomimetic No Down Osteopontin receptor signaling 0.019407198 10.5 NaN SPP1
phenylephrine Sympathomimetic No Up Platelet-derived growth factor receptor signaling 0.029631379 14.5 NaN PDGFB;PDGFRB
phenylephrine Sympathomimetic No Down Platelet-derived growth factor receptor signaling 0.018374809 8 NaN PDGFD;PDGFRA
phenylephrine Sympathomimetic No Down Prostaglandin PGF2 alpha receptor signaling 0.038439436 15.5 NaN PTGFR
phenylephrine Sympathomimetic No Down Removal of caspase inhibition 0.038439436 15.5 NaN XAF1
phenylephrine Sympathomimetic No Down Retinol metabolism 0.001785928 4 NaN ALDH1A1;DHRS3;TTR
phenylephrine Sympathomimetic No Down Serotonin inactivation 0.00037496 1 NaN MAOA;MAOB
phenylephrine Sympathomimetic No Down Syndecan receptor signaling 0.003607424 5 NaN SDC1;SDC3
phenylephrine Sympathomimetic No Up Thin myofilament organization 0.000505368 1 NaN ACTA1;LMOD3;TPM2
phenylephrine Sympathomimetic No Up Thrombospondin receptor signaling 0.003629621 2 NaN THBS2;THBS4
phenylephrine Sympathomimetic No Up Tropoelastin synthesis 0.025052929 11 NaN ELN
phenylephrine Sympathomimetic No Up Water transmembrane transport 0.015849734 7 NaN AQP1;AQP3
phenylephrine Sympathomimetic No Down WNT-Beta-catenin signaling pathway 0.035494567 14 NaN FRZB;FZD7;PAX6;SFRP2
pazopanib Kinase inhibitor Yes Down Alternative complement pathway 0.005081819 2.5 NaN C3;CFH
pazopanib Kinase inhibitor Yes Down CCN intercellular signaling protein family receptor signaling 0.005081819 2.5 NaN CTGF;CYR61
pazopanib Kinase inhibitor Yes Down CD44-Mediated leukocyte rolling 0.045692235 12 NaN CD44
pazopanib Kinase inhibitor Yes Up Cholesterol synthesis 0.006522404 7 22 Up by cardiotoxic TKIs DHCR24;DHCR7;EBP
pazopanib Kinase inhibitor Yes Up Cholesterol-sensitive control of SREBP activation 0.005389583 5.5 15 Up by cardiotoxic TKIs INSIG1;SREBF1
pazopanib Kinase inhibitor Yes Up Citric acid cycle 0.0018093 3 1 Up by cardiotoxic TKIs ACO2;CS;OGDH
pazopanib Kinase inhibitor Yes Up Decorin synthesis 0.019495413 11.5 NaN DCN
pazopanib Kinase inhibitor Yes Up Desaturation of fatty acids 0.007448831 9 11 Up by cardiotoxic TKIs FADS2;SCD
pazopanib Kinase inhibitor Yes Up ER unfolded protein response pathway 0.000380789 2 NaN ATF4;DDIT3;HERPUD1
pazopanib Kinase inhibitor Yes Down Gap junction organization 0.003678073 1 24 Down by cardiotoxic TKIs GJA5;GJC1;PANX1
pazopanib Kinase inhibitor Yes Up Glutamate and glutamine metabolism 0.025620183 13 NaN GLUL;SLC1A5
pazopanib Kinase inhibitor Yes Down Granulocyte macrophage colony-stimulating factor receptor signaling 0.045692235 12 NaN JAK2
pazopanib Kinase inhibitor Yes Down HIF-1 receptor signaling pathway 0.017209911 5 20 Down by cardiotoxic TKIs CITED2;EGLN3
pazopanib Kinase inhibitor Yes Up Lipogenesis 0.038612441 15 NaN FASN
pazopanib Kinase inhibitor Yes Up Lysosomal glycoprotein degradation 0.005389583 5.5 2 Up by cardiotoxic TKIs CTSA;IFI30
pazopanib Kinase inhibitor Yes Up Mammalian target of rapamycin signaling pathway 0.004061432 4 NaN DDIT4;EIF4EBP1;FLCN
pazopanib Kinase inhibitor Yes Down Microfibril scaffold organization 0.045692235 12 NaN FBN1
pazopanib Kinase inhibitor Yes Up Mitochondrial ADP import and ATP export 0.019495413 11.5 NaN SLC25A5
pazopanib Kinase inhibitor Yes Down Osteopontin receptor signaling 0.023112209 7 NaN SPP1
pazopanib Kinase inhibitor Yes Up Peroxisome proliferator-activated receptor alpha signaling 0.038612441 15 NaN PPARA
pazopanib Kinase inhibitor Yes Down Progesterone receptor signaling 0.023112209 7 NaN PGR
pazopanib Kinase inhibitor Yes Down Retinol metabolism 0.035094106 9 NaN ALDH1A3;RDH10
pazopanib Kinase inhibitor Yes Up Serine and glycine metabolism 1.13E-06 1 19 Up by cardiotoxic TKIs AMT;PHGDH;PSAT1;SHMT2;SLC1A5
pazopanib Kinase inhibitor Yes Up Serotonin inactivation 0.038612441 15 NaN MAOB
pazopanib Kinase inhibitor Yes Down Sodium transmembrane transport 0.036972701 10 NaN ATP1A2;SLC38A2;SLC5A1
pazopanib Kinase inhibitor Yes Up Transamination pathways 0.007448831 9 25 Up by cardiotoxic TKIs GOT1;GOT2
pazopanib Kinase inhibitor Yes Down Tropoelastin synthesis 0.023112209 7 NaN ELN
pazopanib Kinase inhibitor Yes Up Vascular endothelial growth factor receptor signaling 0.007448831 9 12 Up by cardiotoxic TKIs VEGFA;VEGFB
pazopanib Kinase inhibitor Yes Down WNT-Beta-catenin signaling pathway 0.015982704 4 NaN APCDD1;CDK14;FZD1;FZD8;SFRP5
olmesartan Antihypertensive No Down Biglycan synthesis 0.022759351 13.5 NaN BGN
olmesartan Antihypertensive No Up Cellular cholesterol uptake and efflux 0.002183285 2 NaN ABCA7;ABCG1;ARL4C
olmesartan Antihypertensive No Down Centrosome separation 0.001242048 2 NaN CCNB1;CDK1;KIF11
olmesartan Antihypertensive No Down Collagen fiber crosslinking 0.00493106 5.5 NaN LOX;LOXL1
olmesartan Antihypertensive No Up Collagen fibril organization by fibril-associated bridges 0.006125965 3 NaN COL9A2;COL9A3
olmesartan Antihypertensive No Up Decorin synthesis 0.020818631 6.5 NaN DCN
olmesartan Antihypertensive No Down Elastin cross-linking and assembly 0.001524767 3 NaN LOX;LOXL1
olmesartan Antihypertensive No Down Extracellular matrix breakdown and membrane shedding by adamalysins 0.016567078 11 NaN ADAMTS14;ADAMTS17;ADAMTS8
olmesartan Antihypertensive No Down Fibrillar collagen core structure organization 4.94E-05 1 NaN COL11A1;COL1A1;COL2A1;COL5A2
olmesartan Antihypertensive No Up Fibulin receptor signaling 0.041205645 10.5 NaN FBLN1
olmesartan Antihypertensive No Down G2 M transition checkpoint 0.029300737 16 NaN CCNB1;CDK1
olmesartan Antihypertensive No Down Glycolysis and Gluconeogenesis 0.01473936 10 NaN ENO1;LDHA;PFKFB3
olmesartan Antihypertensive No Down Granulocyte macrophage colony-stimulating factor receptor signaling 0.045002676 19 NaN JUND
olmesartan Antihypertensive No Up Inhibition of amyloid aggregation, amyloid degradation and uptake 0.001277029 1 NaN A2M;PLAT
olmesartan Antihypertensive No Up Ketone body metabolism 0.020818631 6.5 NaN OXCT1
olmesartan Antihypertensive No Up Lipogenesis 0.041205645 10.5 NaN FASN
olmesartan Antihypertensive No Down Macrophage migration inhibitory factor signaling 0.00493106 5.5 NaN CXCR4;JUND
olmesartan Antihypertensive No Down Mitotic spindle assembly 0.034116484 17 NaN DLGAP5;TPX2
olmesartan Antihypertensive No Down Mitotic spindle disassembly 0.022759351 13.5 NaN CDK1
olmesartan Antihypertensive No Down Natriuretic peptide receptor signaling 0.007285832 7.5 NaN NPPA;NPPB
olmesartan Antihypertensive No Up Platelet-derived growth factor receptor signaling 0.020972888 8 NaN PDGFRB;RGS5
olmesartan Antihypertensive No Down Progesterone receptor signaling 0.022759351 13.5 NaN PGR
olmesartan Antihypertensive No Down Prostaglandin PGF2 alpha receptor signaling 0.045002676 19 NaN PTGFR
olmesartan Antihypertensive No Up Proteasomal regulatory particle organization 0.008459104 4.5 NaN PSMC4;PSMD14
olmesartan Antihypertensive No Down Retinol metabolism 0.002814129 4 NaN ALDH1A1;STRA6;TTR
olmesartan Antihypertensive No Up Roundabout signaling 0.008459104 4.5 NaN ROBO1;ROBO2
olmesartan Antihypertensive No Up Semaphorin signaling 0.033182637 9 NaN DPYSL4;PLXNA2;SEMA3F
olmesartan Antihypertensive No Down Serotonin inactivation 0.045002676 19 NaN MAOA
olmesartan Antihypertensive No Down Sister chromatid segregation 0.007285832 7.5 NaN PTTG1;TOP2A
olmesartan Antihypertensive No Down Thin myofilament organization 0.010047711 9 NaN TNNI3;TPM1
olmesartan Antihypertensive No Down Tropoelastin synthesis 0.022759351 13.5 NaN ELN
olmesartan Antihypertensive No Up WNT-Beta-catenin signaling pathway 0.044085052 12 NaN APCDD1;PAX6;SFRP2;SFRP5
nilotinib Kinase inhibitor No Down Albumin mediated blood protein transport 0.019407198 14 NaN ALB
nilotinib Kinase inhibitor No Up Aspartate and arginine metabolism 0.028324186 28 NaN ARG2;SLC7A1
nilotinib Kinase inhibitor No Down Cardiomyocyte pacemaker current generation 0.009719559 9.5 NaN CACNA1G;TRPM4
nilotinib Kinase inhibitor No Down CCN intercellular signaling protein family receptor signaling 0.003607424 7 NaN CYR61;WISP1
nilotinib Kinase inhibitor No Down CD44-Mediated leukocyte rolling 0.038439436 17 NaN CD44
nilotinib Kinase inhibitor No Up Centrosome duplication 0.028878239 29 NaN CDKN1A;PLK2;PLK4
nilotinib Kinase inhibitor No Up Centrosome maturation 0.003575188 14.5 NaN AURKA;PLK1;TPX2
nilotinib Kinase inhibitor No Up Centrosome organization 0.002308941 13 NaN ASPM;ATF5;NEK2;PLK4;POC1A;TACC3;WDR62
nilotinib Kinase inhibitor No Up Centrosome separation 1.11E-11 1 NaN AURKA;CCNB1;CDK1;ESPL1;KIF11;NEK2;NEK6;SPAG5
nilotinib Kinase inhibitor No Up Cholesterol synthesis 0.015797556 23 NaN DHCR24;DHCR7;MVK
nilotinib Kinase inhibitor No Up Cholesterol-sensitive control of SREBP activation 0.010138932 19.5 NaN INSIG1;SREBF1
nilotinib Kinase inhibitor No Up Contractile ring constriction 0.000187089 6.5 NaN ANLN;ECT2;MYLK
nilotinib Kinase inhibitor No Down Decorin synthesis 0.019407198 14 NaN DCN
nilotinib Kinase inhibitor No Up Desaturation of fatty acids 0.013942946 22 NaN FADS2;SCD
nilotinib Kinase inhibitor No Down Epithelial intermediate filament dynamics 0.009719559 9.5 NaN KRT19;KRT7
nilotinib Kinase inhibitor No Up Equatorial RhoA activation 0.004203747 16.5 NaN ECT2;KIF23
nilotinib Kinase inhibitor No Up ER unfolded protein response pathway 0.000986163 11 NaN ATF4;DDIT3;HERPUD1
nilotinib Kinase inhibitor No Up Eukaryotic kinetochore dynamics 1.74E-10 2 NaN BUB1;CENPE;CENPF;KIF15;KNSTRN;MAD2L1;NDC80;NUF2;SKA3;SPC24;TTK;ZWINT
nilotinib Kinase inhibitor No Down Extracellular matrix breakdown and membrane shedding by adamalysins 0.001080992 4 NaN ADAM12;ADAM19;ADAMTS5;ADAMTS6
nilotinib Kinase inhibitor No Down Extracellular matrix breakdown by cathepsins 0.015226725 12 NaN CTSF;CTSV
nilotinib Kinase inhibitor No Down Fibrillar collagen core structure organization 2.64E-05 2 NaN COL11A1;COL11A2;COL1A1;COL2A1
nilotinib Kinase inhibitor No Up G2 M transition checkpoint 0.003575188 14.5 NaN CCNB1;CDC25C;CDK1
nilotinib Kinase inhibitor No Up GABA metabolism 0.010138932 19.5 NaN ABAT;SLC6A1
nilotinib Kinase inhibitor No Down Granulocyte macrophage colony-stimulating factor receptor signaling 0.038439436 17 NaN JAK2
nilotinib Kinase inhibitor No Up Growth differentiation factor receptor signaling 0.018261874 24 NaN GDF15;GDF2
nilotinib Kinase inhibitor No Up Hyaluronan-mediated motility receptor signaling 0.026993649 26 NaN HMMR
nilotinib Kinase inhibitor No Up Inhibition of apoptosis 0.04009759 30 NaN BIRC5;IFI6
nilotinib Kinase inhibitor No Up Intracellular bridge assembly 0.002140056 12 NaN INCENP;KIF23
nilotinib Kinase inhibitor No Up Metaphase to anaphase checkpoint 1.96E-07 3 NaN BUB1;BUB1B;CCNB2;CDC20;CENPE;MAD2L1;MXD3;PTTG1;TTK
nilotinib Kinase inhibitor No Up Mitotic chromosome condensation 0.000628897 9 NaN INCENP;NCAPG2;SMC4
nilotinib Kinase inhibitor No Up Mitotic H3 phosphorylation and dephosphorylation 0.000187089 6.5 NaN AURKB;CCNA2;INCENP
nilotinib Kinase inhibitor No Up Mitotic spindle assembly 5.39E-07 4 NaN CKAP2;DLGAP5;NUSAP1;TACC3;TPX2;TTK
nilotinib Kinase inhibitor No Up Mitotic spindle disassembly 0.026993649 26 NaN CDK1
nilotinib Kinase inhibitor No Up Nuclear envelope maintenance 0.010138932 19.5 NaN LMNB1;TMPO
nilotinib Kinase inhibitor No Up Nuclear intermediate filaments 0.010138932 19.5 NaN LMNB1;TMPO
nilotinib Kinase inhibitor No Down Osteopontin receptor signaling 0.019407198 14 NaN SPP1
nilotinib Kinase inhibitor No Down Potassium transmembrane transport 0.010803729 11 NaN ABCC9;ATP1A2;FXYD1
nilotinib Kinase inhibitor No Down Retinol metabolism 0.001785928 6 NaN ALDH1A1;ALDH1A3;STRA6
nilotinib Kinase inhibitor No Up Serine and glycine metabolism 5.61E-06 5 NaN PHGDH;PSAT1;PSPH;SHMT2;SLC1A5
nilotinib Kinase inhibitor No Up Sister chromatid attachment to mitotic spindle 0.00072634 10 NaN NUF2;TACC3
nilotinib Kinase inhibitor No Up Sister chromatid segregation 0.000366694 8 NaN ESPL1;PTTG1;TOP2A
nilotinib Kinase inhibitor No Down Thick myofilament organization 0.001110457 5 NaN MYBPC3;MYH7
nilotinib Kinase inhibitor No Down Thin myofilament organization 0.00023825 3 NaN ACTA1;TNNI3;TPM2
nilotinib Kinase inhibitor No Up Thrombospondin receptor signaling 0.004203747 16.5 NaN THBS1;THBS4
nilotinib Kinase inhibitor No Up Tropoelastin synthesis 0.026993649 26 NaN ELN
nilotinib Kinase inhibitor No Down Vascular endothelial growth factor receptor signaling 0.007383606 8 NaN FLT1;KDR
nilotinib Kinase inhibitor No Down Vasoactive intestinal peptide receptor signaling 0.038439436 17 NaN VIPR2
nilotinib Kinase inhibitor No Down Z-disc organization 9.65E-06 1 NaN ACTN2;CSRP3;LDB3;PDLIM3;TCAP
milrinone Vasodilatator Yes Down Aggrecan synthesis 0.024258998 11 NaN ACAN
milrinone Vasodilatator Yes Up Albumin mediated blood protein transport 0.019936486 15 NaN ALB
milrinone Vasodilatator Yes Up Alternative complement pathway 0.003803269 6 NaN C3;CFH
milrinone Vasodilatator Yes Down Antigen presentation via MHC class I molecules 0.00149326 4 NaN HLA-A;HLA-B;HLA-C
milrinone Vasodilatator Yes Up Biglycan synthesis 0.019936486 15 NaN BGN
milrinone Vasodilatator Yes Down CD44-Mediated leukocyte rolling 0.047931585 20 NaN CD44
milrinone Vasodilatator Yes Down Cellular cholesterol uptake and efflux 0.003371923 5 NaN ABCA1;ABCG1;SCARA3
milrinone Vasodilatator Yes Up Chaperone-mediated autophagy 0.039477231 20.5 NaN HSPA8
milrinone Vasodilatator Yes Up Classical complement pathway 0.007778956 10 NaN C4A;C4B
milrinone Vasodilatator Yes Down Decorin synthesis 0.024258998 11 NaN DCN
milrinone Vasodilatator Yes Up Endogenous control of complement activity 0.003803269 6 NaN CFH;CFI
milrinone Vasodilatator Yes Up Extracellular matrix breakdown and membrane shedding by adamalysins 0.001194517 3 NaN ADAM12;ADAMTS14;ADAMTS2;ADAMTS5
milrinone Vasodilatator Yes Down Fibrillar collagen core structure organization 6.34E-05 1 NaN COL1A1;COL1A2;COL2A1;COL3A1
milrinone Vasodilatator Yes Up Fibronectin synthesis and extracellular assembly 0.003803269 6 NaN FN1;ITGB3
milrinone Vasodilatator Yes Up Gap junction organization 0.030757337 17 NaN GJA1;GJA5
milrinone Vasodilatator Yes Down Glutamate and glutamine metabolism 0.000203815 3 NaN SLC1A3;SLC1A5;SLC38A2;SLC7A5
milrinone Vasodilatator Yes Up Granulocyte macrophage colony-stimulating factor receptor signaling 0.039477231 20.5 NaN JAK2
milrinone Vasodilatator Yes Down Granulocyte macrophage colony-stimulating factor receptor signaling 0.047931585 20 NaN JUND
milrinone Vasodilatator Yes Up Granulocyte-colony stimulating factor receptor signaling 0.012989342 12 NaN SOCS3;STAT3
milrinone Vasodilatator Yes Down Hepatocyte growth factor receptor signaling 0.047931585 20 NaN MET
milrinone Vasodilatator Yes Up Inhibition of amyloid aggregation, amyloid degradation and uptake 0.001171577 2 NaN A2M;MME
milrinone Vasodilatator Yes Up Interleukin 6 receptor signaling 0.039477231 20.5 NaN JAK3
milrinone Vasodilatator Yes Up Interleukin 7 receptor signaling 0.039477231 20.5 NaN JAK3
milrinone Vasodilatator Yes Up JAK-STAT signaling pathway 0.000131598 1 NaN SOCS2;SOCS3;STAT3;STAT4
milrinone Vasodilatator Yes Up Leptin receptor signaling 0.00231233 4 NaN SOCS3;STAT3
milrinone Vasodilatator Yes Down Macrophage migration inhibitory factor signaling 0.005586664 8 NaN CXCR4;JUND
milrinone Vasodilatator Yes Up Mammalian target of rapamycin signaling pathway 0.044211458 25 NaN DDIT4;RICTOR
milrinone Vasodilatator Yes Down MAPK signaling pathway 0.035387843 15 NaN DUSP1;MAP2K6;RPS6KA2
milrinone Vasodilatator Yes Up Methionine cycle 0.039477231 20.5 NaN BHMT
milrinone Vasodilatator Yes Up Microfibril scaffold organization 0.039477231 20.5 NaN FBN1
milrinone Vasodilatator Yes Up Natriuretic peptide receptor signaling 0.0056301 8 NaN NPPA;NPPB
milrinone Vasodilatator Yes Down Osteonectin receptor signaling 0.003406483 6 NaN SMOC2;SPOCK1
milrinone Vasodilatator Yes Up Osteopontin receptor signaling 0.019936486 15 NaN SPP1
milrinone Vasodilatator Yes Down Platelet-derived growth factor receptor signaling 0.027912485 14 NaN PDGFB;TNK2
milrinone Vasodilatator Yes Down Progesterone receptor signaling 0.024258998 11 NaN PGR
milrinone Vasodilatator Yes Down Removal of caspase inhibition 0.047931585 20 NaN XAF1
milrinone Vasodilatator Yes Up Restriction point 0.016025171 13 NaN CDKN2A;PFKFB3
milrinone Vasodilatator Yes Down Retinol metabolism 0.038347708 16 NaN ALDH1A3;RLBP1
milrinone Vasodilatator Yes Down Serine and glycine metabolism 9.78E-05 2 NaN GLDC;PHGDH;SHMT2;SLC1A5
milrinone Vasodilatator Yes Down Serotonin inactivation 0.047931585 20 NaN MAOA
milrinone Vasodilatator Yes Up Thin myofilament organization 0.007778956 10 NaN ACTA1;LMOD3
milrinone Vasodilatator Yes Down Tropoelastin synthesis 0.024258998 11 NaN ELN
milrinone Vasodilatator Yes Up Vascular endothelial growth factor receptor signaling 0.007778956 10 NaN KDR;VEGFA
milrinone Vasodilatator Yes Down Vasoactive intestinal peptide receptor signaling 0.047931585 20 NaN VIPR2
milrinone Vasodilatator Yes Down Versican receptor signaling 0.047931585 20 NaN VCAN
milrinone Vasodilatator Yes Down Versican synthesis 0.024258998 11 NaN VCAN
milrinone Vasodilatator Yes Down WNT-Beta-catenin signaling pathway 0.004454715 7 NaN APCDD1;FRZB;FZD1;SFRP1;SFRP2;SFRP5
milrinone Vasodilatator Yes Up Z-disc organization 0.039518883 24 NaN DES;TCAP
lapatinib Kinase inhibitor Yes Down Axonal intermediate filament dynamics 0.013510309 18 NaN NEFM;NES
lapatinib Kinase inhibitor Yes Down Biglycan synthesis 0.026552576 22 18 Down by cardiotoxic TKIs BGN
lapatinib Kinase inhibitor Yes Down Centrosome separation 0.001936235 5 NaN CDK1;KIF11;NEK6
lapatinib Kinase inhibitor Yes Up Cholesterol synthesis 2.52E-18 1 22 Up by cardiotoxic TKIs CYP51A1;DHCR24;DHCR7;FDFT1;FDPS;HMGCR;HMGCS1;LSS;MSMO1;MVD;MVK;NSDHL;SQLE
lapatinib Kinase inhibitor Yes Up Cholesterol-sensitive control of SREBP activation 0.000136265 2 15 Up by cardiotoxic TKIs INSIG1;SREBF1;SREBF2
lapatinib Kinase inhibitor Yes Down Collagen fiber crosslinking 0.006664064 12.5 NaN LOX;LOXL1
lapatinib Kinase inhibitor Yes Down Collagen fibril organization by fibril-associated bridges 0.009821443 15 NaN COL9A1;COL9A2
lapatinib Kinase inhibitor Yes Down Contractile ring constriction 0.000178158 2 NaN ANLN;MYH14;MYLK
lapatinib Kinase inhibitor Yes Up Decorin synthesis 0.019318984 12 NaN DCN
lapatinib Kinase inhibitor Yes Up Desaturation of fatty acids 0.000235064 3 11 Up by cardiotoxic TKIs FADS1;FADS2;SCD
lapatinib Kinase inhibitor Yes Down DNA replication elongation 0.006664064 12.5 NaN MCM5;PCNA
lapatinib Kinase inhibitor Yes Down DNA replication initiation 0.003966921 8 NaN CDC6;MCM10;MCM5;MCM6
lapatinib Kinase inhibitor Yes Down Elastin cross-linking and assembly 0.002071198 6.5 NaN LOX;LOXL1
lapatinib Kinase inhibitor Yes Down Eukaryotic kinetochore dynamics 5.40E-05 1 NaN BUB1;CENPE;CENPF;CENPU;SPC24;TTK;ZWINT
lapatinib Kinase inhibitor Yes Up Extracellular matrix breakdown and membrane shedding by adamalysins 0.010671147 10 NaN ADAM33;ADAMTS2;ADAMTS5
lapatinib Kinase inhibitor Yes Down Extracellular matrix breakdown and membrane shedding by adamalysins 0.024834371 19 NaN ADAM19;ADAMTS12;ADAMTS8
lapatinib Kinase inhibitor Yes Down Fanconi anemia interstrand cross-link repair pathway 0.004591664 11 NaN BRCA2;BRIP1;FANCD2;FANCI
lapatinib Kinase inhibitor Yes Down Glutamate and glutamine metabolism 0.004349738 10 NaN SLC1A5;SLC38A2;SLC7A5
lapatinib Kinase inhibitor Yes Up Granulocyte macrophage colony-stimulating factor receptor signaling 0.038266416 15 NaN JUND
lapatinib Kinase inhibitor Yes Up Granulocyte-colony stimulating factor receptor signaling 0.012230733 11 16 Up by cardiotoxic TKIs SOCS3;STAT3
lapatinib Kinase inhibitor Yes Up Heme degradation to bilirubin 0.001100428 4.5 NaN BLVRB;HMOX1
lapatinib Kinase inhibitor Yes Up Inhibition of amyloid aggregation, amyloid degradation and uptake 0.001100428 4.5 NaN A2M;MME
lapatinib Kinase inhibitor Yes Up Interferon alpha receptor signaling 0.009634616 9 NaN IRF9;STAT1
lapatinib Kinase inhibitor Yes Up Interferon beta receptor signaling 0.007318648 8 NaN IFIT2;IRF9
lapatinib Kinase inhibitor Yes Down Intracellular bridge assembly 0.002071198 6.5 NaN KIF23;NEK7
lapatinib Kinase inhibitor Yes Up Intrinsic apoptosis pathway 0.029019694 13 NaN BCL2L11;BMF
lapatinib Kinase inhibitor Yes Up JAK-STAT signaling pathway 0.00221172 7 NaN SOCS3;STAT1;STAT3
lapatinib Kinase inhibitor Yes Up Leptin receptor signaling 0.002172807 6 5 Up by cardiotoxic TKIs SOCS3;STAT3
lapatinib Kinase inhibitor Yes Up Lipogenesis 0.038266416 15 NaN FASN
lapatinib Kinase inhibitor Yes Down Metaphase to anaphase checkpoint 0.001887856 4 NaN BUB1;BUB1B;CENPE;PTTG1;TTK
lapatinib Kinase inhibitor Yes Down Mitotic spindle assembly 0.00028822 3 NaN DLGAP5;NUSAP1;TPX2;TTK
lapatinib Kinase inhibitor Yes Down Mitotic spindle disassembly 0.026552576 22 NaN CDK1
lapatinib Kinase inhibitor Yes Down Natriuretic peptide receptor signaling 0.009821443 15 NaN NPPA;NPPB
lapatinib Kinase inhibitor Yes Down Osteonectin receptor signaling 0.004069701 9 NaN SPARC;SPOCK1
lapatinib Kinase inhibitor Yes Down Osteopontin receptor signaling 0.026552576 22 NaN SPP1
lapatinib Kinase inhibitor Yes Down Retinol metabolism 0.045193362 25 NaN ALDH1A1;ALDH1A3
lapatinib Kinase inhibitor Yes Down Sister chromatid segregation 0.009821443 15 NaN PTTG1;TOP2A
lapatinib Kinase inhibitor Yes Down Tight junction organization 0.012068674 17 NaN CLDN1;CLDN6;CRB2;MYLK
lapatinib Kinase inhibitor Yes Down Tropoelastin synthesis 0.026552576 22 NaN ELN
lapatinib Kinase inhibitor Yes Up Vasoactive intestinal peptide receptor signaling 0.038266416 15 NaN VIPR1
lapatinib Kinase inhibitor Yes Down Versican synthesis 0.026552576 22 NaN VCAN
isoprenaline Sympathomimetic No Down Acetylcholine-mediated control of postsynaptic potential 0.006934528 5 NaN AGRN;DOK7
isoprenaline Sympathomimetic No Up Adrenergic receptor signaling 0.000413387 4 NaN GNB3;GRK5;PDE4D;RASD1;RGS16
isoprenaline Sympathomimetic No Up Aggrecan synthesis 0.025141143 14.5 NaN ACAN
isoprenaline Sympathomimetic No Down Albumin mediated blood protein transport 0.018789697 8.5 NaN ALB
isoprenaline Sympathomimetic No Up Amyloid plaque organization 0.029825004 17 NaN COL25A1;HSPB6
isoprenaline Sympathomimetic No Up Androgen receptor signaling 0.049652372 23 NaN AR
isoprenaline Sympathomimetic No Down Antigen presentation via MHC class I molecules 0.000712003 1.5 NaN HLA-A;HLA-B;HLA-C
isoprenaline Sympathomimetic No Down Basement membrane assembly and organization 0.000712003 1.5 NaN COL4A3;COL4A4;COL8A2
isoprenaline Sympathomimetic No Down Biglycan synthesis 0.018789697 8.5 NaN BGN
isoprenaline Sympathomimetic No Up CCN intercellular signaling protein family receptor signaling 0.005990412 7 NaN CTGF;CYR61
isoprenaline Sympathomimetic No Up CD44-Mediated leukocyte rolling 0.049652372 23 NaN CD44
isoprenaline Sympathomimetic No Up Cellular fatty acid uptake 0.049652372 23 NaN CD36
isoprenaline Sympathomimetic No Up Cellular iron uptake and export 0.040928231 20 NaN RASD1;TFRC
isoprenaline Sympathomimetic No Up Cholesterol synthesis 9.94E-19 1 NaN CYP51A1;DHCR24;DHCR7;EBP;FDFT1;FDPS;HMGCR;HMGCS1;LSS;MSMO1;MVD;MVK;NSDHL;SQLE
isoprenaline Sympathomimetic No Up Cholesterol-sensitive control of SREBP activation 0.008836966 9 NaN INSIG1;SREBF1
isoprenaline Sympathomimetic No Up Coagulation cascade 0.035205397 19 NaN F2RL1;TFPI
isoprenaline Sympathomimetic No Up Collagen fibril organization by fibril-associated bridges 0.000297304 3 NaN COL12A1;COL14A1;COL19A1
isoprenaline Sympathomimetic No Up Desaturation of fatty acids 0.000510607 5 NaN FADS1;FADS2;SCD
isoprenaline Sympathomimetic No Up Fatty acid elongation 0.020177706 13 NaN ELOVL5;ELOVL6
isoprenaline Sympathomimetic No Up Fibrillar collagen core structure organization 2.20E-06 2 NaN COL11A1;COL11A2;COL1A2;COL2A1;COL3A1
isoprenaline Sympathomimetic No Down Fibrillar collagen core structure organization 0.014318179 6 NaN COL1A1;COL5A1
isoprenaline Sympathomimetic No Up G-protein coupled receptor signaling pathway 0.013058143 12 NaN GRK5;PDE4D;RGS16
isoprenaline Sympathomimetic No Up Granulocyte macrophage colony-stimulating factor receptor signaling 0.049652372 23 NaN JAK2
isoprenaline Sympathomimetic No Down Granulocyte macrophage colony-stimulating factor receptor signaling 0.037227967 12.5 NaN JUND
isoprenaline Sympathomimetic No Up Lipogenesis 0.000629915 6 NaN ACLY;FASN
isoprenaline Sympathomimetic No Down Macrophage migration inhibitory factor signaling 0.003385224 3 NaN CXCR4;JUND
isoprenaline Sympathomimetic No Up Microfibril scaffold organization 0.049652372 23 NaN FBN1
isoprenaline Sympathomimetic No Down Mitotic spindle assembly 0.023917892 11 NaN DLGAP5;NUSAP1
isoprenaline Sympathomimetic No Up Muscarinic receptor signaling 0.008836966 9 NaN CHRM1;CHRM4
isoprenaline Sympathomimetic No Up Natriuretic peptide receptor signaling 0.008836966 9 NaN NPPA;NPPB
isoprenaline Sympathomimetic No Up Perlecan synthesis 0.025141143 14.5 NaN HSPG2
isoprenaline Sympathomimetic No Up Platelet-derived growth factor receptor signaling 0.029825004 17 NaN PDGFRA;PDGFRB
isoprenaline Sympathomimetic No Down Semaphorin signaling 0.00361285 4 NaN CRMP1;DPYSL4;NRP2;PLXNA2
isoprenaline Sympathomimetic No Up Serine and glycine metabolism 0.029825004 17 NaN PHGDH;SLC1A4
isoprenaline Sympathomimetic No Up Thin myofilament organization 0.012167509 11 NaN TNNI3;TPM2
isoprenaline Sympathomimetic No Down Tropoelastin synthesis 0.018789697 8.5 NaN ELN
isoprenaline Sympathomimetic No Down Versican receptor signaling 0.037227967 12.5 NaN VCAN
isoprenaline Sympathomimetic No Down Versican synthesis 0.018789697 8.5 NaN VCAN
insulin-like growth factor 1 Hormone No Down Actin filament bundling and crosslinking 0.019414005 19 NaN FLNA;PLS3;SYNPO;TAGLN
insulin-like growth factor 1 Hormone No Down Aggrecan synthesis 0.040402258 28 NaN ACAN
insulin-like growth factor 1 Hormone No Up Alternative complement pathway 0.030931719 7.5 NaN C3
insulin-like growth factor 1 Hormone No Down Alternative complement pathway 0.015017541 17 NaN C1S;CFH
insulin-like growth factor 1 Hormone No Down Antigen presentation via MHC class I molecules 0.000454745 5 NaN B2M;HLA-A;HLA-B;HLA-C
insulin-like growth factor 1 Hormone No Down Biglycan synthesis 0.040402258 28 NaN BGN
insulin-like growth factor 1 Hormone No Down CCN intercellular signaling protein family receptor signaling 1.27E-05 2 NaN CTGF;CYR61;NOV;WISP1
insulin-like growth factor 1 Hormone No Up Cholesterol-sensitive control of SREBP activation 0.000570829 1 NaN INSIG1;SREBF1
insulin-like growth factor 1 Hormone No Down Classical complement pathway 8.35E-05 4 NaN C1QB;C1QC;C1R;C1S
insulin-like growth factor 1 Hormone No Down Collagen fiber crosslinking 0.015017541 17 NaN LOX;PXDN
insulin-like growth factor 1 Hormone No Up Contractile ring constriction 0.030931719 7.5 NaN MYH14
insulin-like growth factor 1 Hormone No Up Contractile ring formation 0.030931719 7.5 NaN MYH14
insulin-like growth factor 1 Hormone No Down Decorin synthesis 0.040402258 28 NaN DCN
insulin-like growth factor 1 Hormone No Up Desaturation of fatty acids 0.043038559 11 NaN SCD
insulin-like growth factor 1 Hormone No Down Endogenous control of complement activity 0.015017541 17 NaN CFH;CFI
insulin-like growth factor 1 Hormone No Down Epithelial intermediate filament dynamics 0.038799267 24 NaN KRT7;KRT8
insulin-like growth factor 1 Hormone No Down Extracellular matrix breakdown and membrane shedding by adamalysins 0.002366842 8 NaN ADAM12;ADAMTS12;ADAMTS2;ADAMTS4;ADAMTS8
insulin-like growth factor 1 Hormone No Down Extracellular matrix breakdown by heparanases and sulfatases 0.009257136 11.5 NaN SULF1;SULF2
insulin-like growth factor 1 Hormone No Down Extracellular matrix breakdown by matrix metalloproteases 0.004586711 9 NaN MMP1;MMP14;MMP2
insulin-like growth factor 1 Hormone No Down Extracellular matrix breakdown by serine proteases 0.029887387 21.5 NaN HTRA1;PRSS12
insulin-like growth factor 1 Hormone No Down Fibrillar collagen core structure organization 1.81E-08 1 NaN COL11A1;COL1A1;COL1A2;COL3A1;COL5A1;COL5A2;COL5A3
insulin-like growth factor 1 Hormone No Up GABA metabolism 0.037003897 10 NaN SLC6A1
insulin-like growth factor 1 Hormone No Up Glycogen synthesis and glycogenolysis 0.004385318 2 NaN PPP1R3A;PYGM
insulin-like growth factor 1 Hormone No Down Growth differentiation factor receptor signaling 0.038799267 24 NaN GDF2;GDF6
insulin-like growth factor 1 Hormone No Down Inhibin receptor signaling 0.038799267 24 NaN INHBA;INHBE
insulin-like growth factor 1 Hormone No Down Inhibition of amyloid aggregation, amyloid degradation and uptake 6.55E-05 3 NaN A2M;MME;PLAT
insulin-like growth factor 1 Hormone No Down Inhibition of apoptosis 0.010974619 13 NaN IFI6;PEA15;XAF1
insulin-like growth factor 1 Hormone No Up Lipogenesis 0.012487785 3.5 NaN FASN
insulin-like growth factor 1 Hormone No Down Microfibril scaffold organization 0.001628922 7 NaN FBN1;MFAP2
insulin-like growth factor 1 Hormone No Down Natriuretic peptide receptor signaling 0.021928273 20 NaN NPPA;NPPB
insulin-like growth factor 1 Hormone No Down Osteonectin receptor signaling 0.009257136 11.5 NaN SMOC2;SPARC
insulin-like growth factor 1 Hormone No Down Osteopontin receptor signaling 0.040402258 28 NaN SPP1
insulin-like growth factor 1 Hormone No Up Peroxisome proliferator-activated receptor gamma signaling 0.024821795 5 NaN PPARGC1B
insulin-like growth factor 1 Hormone No Down Procollagen processing in the ER 0.004755694 10 NaN P3H1;SERPINH1
insulin-like growth factor 1 Hormone No Down Retinol metabolism 0.013845369 14 NaN ALDH1A1;ALDH1A3;TTR
insulin-like growth factor 1 Hormone No Down Serine and glycine metabolism 0.000691879 6 NaN PHGDH;PSAT1;SHMT2;SLC1A5
insulin-like growth factor 1 Hormone No Up Serotonin inactivation 0.012487785 3.5 NaN MAOA
insulin-like growth factor 1 Hormone No Up Sulfonation 0.030931719 7.5 NaN SULT1A1
insulin-like growth factor 1 Hormone No Down Thin myofilament organization 0.029887387 21.5 NaN ACTA1;TPM4
insulin-like growth factor 1 Hormone No Down Tropoelastin synthesis 0.040402258 28 NaN ELN
insulin-like growth factor 1 Hormone No Down WNT-Beta-catenin signaling pathway 0.014304543 15 NaN CTHRC1;DKK2;DKK3;FZD7;SFRP2;SFRP4;WNT2
imatinib Kinase inhibitor No Down Biglycan synthesis 0.026287932 17 NaN BGN
imatinib Kinase inhibitor No Up Centrosome maturation 5.33E-05 4 NaN AURKA;CDC25B;PLK1;TPX2
imatinib Kinase inhibitor No Up Centrosome organization 0.038825593 22 NaN ASPM;NEK2;POC1A;TACC3
imatinib Kinase inhibitor No Up Centrosome separation 8.58E-11 2 NaN AURKA;CCNB1;CDK1;ESPL1;KIF11;NEK2;SPAG5
imatinib Kinase inhibitor No Up Cholesterol synthesis 1.56E-20 1 NaN CYP51A1;DHCR24;DHCR7;EBP;FDFT1;FDPS;HMGCR;HMGCS1;LSS;MSMO1;MVD;MVK;NSDHL;SQLE
imatinib Kinase inhibitor No Up Cholesterol-sensitive control of SREBP activation 0.005015101 12 NaN INSIG1;SREBF1
imatinib Kinase inhibitor No Up Citric acid cycle 0.001627653 11 NaN OGDH;PDHA1;SDHA
imatinib Kinase inhibitor No Down Collagen fiber crosslinking 0.006535173 9 NaN LOX;PXDN
imatinib Kinase inhibitor No Down Collagen fibril organization by fibril-associated bridges 7.13E-08 2 NaN COL12A1;COL14A1;COL9A1;COL9A2;COL9A3
imatinib Kinase inhibitor No Down Decorin synthesis 0.026287932 17 NaN DCN
imatinib Kinase inhibitor No Up Desaturation of fatty acids 0.006934528 13.5 NaN FADS2;SCD
imatinib Kinase inhibitor No Up Electron transport chain 0.020488625 17 NaN COX7A1;SDHA
imatinib Kinase inhibitor No Down Epithelial intermediate filament dynamics 0.017367241 11 NaN KRT19;KRT7
imatinib Kinase inhibitor No Up Eukaryotic kinetochore dynamics 0.000676926 8 NaN BUB1;CENPE;CENPF;KNSTRN;NDC80
imatinib Kinase inhibitor No Down Extracellular matrix breakdown and membrane shedding by adamalysins 0.00034208 4 NaN ADAM12;ADAMTS14;ADAMTS2;ADAMTS4;ADAMTS8
imatinib Kinase inhibitor No Down Extracellular matrix breakdown by matrix metalloproteases 0.021945601 13.5 NaN MMP14;MMP2
imatinib Kinase inhibitor No Down Fibrillar collagen core structure organization 6.03E-08 1 NaN COL11A1;COL1A1;COL1A2;COL3A1;COL5A1;COL5A3
imatinib Kinase inhibitor No Up G2 M transition checkpoint 0.001269544 10 NaN CCNB1;CDC25B;CDK1
imatinib Kinase inhibitor No Up Gap junction organization 0.027563704 18.5 NaN GJA1;GJA5
imatinib Kinase inhibitor No Down Glycolysis and Gluconeogenesis 0.021582273 12 NaN HK2;LDHA;PGK1
imatinib Kinase inhibitor No Down HIF-1 receptor signaling pathway 0.021945601 13.5 NaN CITED2;EGLN3
imatinib Kinase inhibitor No Down Inhibition of amyloid aggregation, amyloid degradation and uptake 0.002030414 6 NaN MME;PLAT
imatinib Kinase inhibitor No Up Intracellular bridge assembly 0.001041194 9 NaN INCENP;KIF23
imatinib Kinase inhibitor No Up JAK-STAT signaling pathway 0.027563704 18.5 NaN SOCS2;STAT4
imatinib Kinase inhibitor No Up Lipogenesis 0.037227967 20.5 NaN FASN
imatinib Kinase inhibitor No Up Metaphase to anaphase checkpoint 3.55E-05 3 NaN BUB1;BUB1B;CCNB2;CDC20;CENPE;PTTG1
imatinib Kinase inhibitor No Up Mitochondrial ADP import and ATP export 0.018789697 15.5 NaN SLC25A5
imatinib Kinase inhibitor No Up Mitotic H3 phosphorylation and dephosphorylation 6.36E-05 5 NaN AURKB;CCNA2;INCENP
imatinib Kinase inhibitor No Up Mitotic spindle assembly 7.58E-05 6 NaN DLGAP5;NUSAP1;TACC3;TPX2
imatinib Kinase inhibitor No Up Mitotic spindle disassembly 0.018789697 15.5 NaN CDK1
imatinib Kinase inhibitor No Down Natriuretic peptide receptor signaling 0.009633191 10 NaN NPPB;NPR3
imatinib Kinase inhibitor No Down Osteopontin receptor signaling 0.026287932 17 NaN SPP1
imatinib Kinase inhibitor No Down Platelet-derived growth factor receptor signaling 0.002536833 7 NaN PDGFRA;PDGFRB;RGS5
imatinib Kinase inhibitor No Down Progesterone receptor signaling 0.026287932 17 NaN PGR
imatinib Kinase inhibitor No Down Retinol metabolism 0.00027738 3 NaN ALDH1A1;ALDH1A3;RDH10;STRA6
imatinib Kinase inhibitor No Up Sister chromatid attachment to mitotic spindle 0.037227967 20.5 NaN TACC3
imatinib Kinase inhibitor No Up Sister chromatid segregation 0.000125472 7 NaN ESPL1;PTTG1;TOP2A
imatinib Kinase inhibitor No Down Tenascin receptor signaling 0.003990278 8 NaN TENM1;TNC
imatinib Kinase inhibitor No Up Transamination pathways 0.006934528 13.5 NaN GOT1;GOT2
imatinib Kinase inhibitor No Down Tropoelastin synthesis 0.026287932 17 NaN ELN
imatinib Kinase inhibitor No Down WNT-Beta-catenin signaling pathway 0.001392668 5 NaN CTHRC1;DKK1;DKK2;FRZB;FZD2;PAX6;SFRP2
idarubicin Anthracycline Yes Up Bicarbonate transmembrane transport 0.012073295 10.5 NaN SLC26A8;SLC26A9;SLC4A10
idarubicin Anthracycline Yes Up Biglycan synthesis 0.025758645 15.5 NaN BGN
idarubicin Anthracycline Yes Up Cell cycle arrest in response to DNA damage 0.022948589 13 NaN BBC3;CDKN1A;MDM2
idarubicin Anthracycline Yes Down Centrosome maturation 0.022330855 16.5 NaN PLK1;TPX2
idarubicin Anthracycline Yes Down Centrosome separation 2.79E-05 2 NaN CCNB1;CDK1;KIF11;SPAG5
idarubicin Anthracycline Yes Down Chaperone-mediated autophagy 0.038958404 19.5 NaN HSPA8
idarubicin Anthracycline Yes Up Chloride transmembrane transport 0.042773869 19 NaN CFTR;SLC26A8
idarubicin Anthracycline Yes Up Coagulation cascade 0.003131352 7 NaN F11;F5;KLKB1
idarubicin Anthracycline Yes Up Coagulation factor synthesis and vitamin K metabolism 0.009261749 9 NaN F11;F5
idarubicin Anthracycline Yes Down Contractile ring constriction 0.003704726 8 NaN ANLN;MYH14
idarubicin Anthracycline Yes Down Contractile ring formation 0.003704726 8 NaN MYH14;RACGAP1
idarubicin Anthracycline Yes Up Decorin synthesis 0.025758645 15.5 NaN DCN
idarubicin Anthracycline Yes Up Desmosome organization 0.012073295 10.5 NaN DSG1;DSG3;DSG4
idarubicin Anthracycline Yes Down DNA replication elongation 7.30E-05 3 NaN MCM2;MCM5;MCM7
idarubicin Anthracycline Yes Down DNA replication initiation 0.012553809 12 NaN MCM2;MCM5;MCM7
idarubicin Anthracycline Yes Up Epithelial intermediate filament dynamics 0.016709342 12 NaN KRT19;KRT8
idarubicin Anthracycline Yes Down Eukaryotic kinetochore dynamics 7.79E-06 1 NaN BUB1;CENPE;CENPF;CENPU;MTUS2;TTK;ZWINT
idarubicin Anthracycline Yes Down Extracellular matrix breakdown and membrane shedding by adamalysins 0.011207265 11 NaN ADAM15;ADAMTS1;ADAMTS14
idarubicin Anthracycline Yes Up Extracellular matrix breakdown by matrix metalloproteases 0.00126627 3 NaN MMP1;MMP14;MMP2
idarubicin Anthracycline Yes Up Extrinsic apoptosis pathway 0.000548269 2 NaN FAS;TNFRSF10A;TNFRSF10B
idarubicin Anthracycline Yes Up Fibrillar collagen core structure organization 8.01E-05 1 NaN COL1A1;COL1A2;COL3A1;COL5A1
idarubicin Anthracycline Yes Down G2 M transition checkpoint 0.001449092 5 NaN CCNB1;CDK1;WEE1
idarubicin Anthracycline Yes Down Granulocyte macrophage colony-stimulating factor receptor signaling 0.038958404 19.5 NaN JAK2
idarubicin Anthracycline Yes Up Inhibition of amyloid aggregation, amyloid degradation and uptake 0.001950041 5 NaN A2M;PLAT
idarubicin Anthracycline Yes Down Intracellular bridge abscission 0.01712795 13 NaN CEP55;EXOC6B;TEX14
idarubicin Anthracycline Yes Up Intrinsic apoptosis pathway 0.004987 8 NaN BAX;BBC3;BCL2L1
idarubicin Anthracycline Yes Down Metaphase to anaphase checkpoint 0.000492096 4 NaN BUB1;CCNB2;CDC20;CENPE;TTK
idarubicin Anthracycline Yes Down Mitotic H3 phosphorylation and dephosphorylation 0.003704726 8 NaN AURKB;CCNA2
idarubicin Anthracycline Yes Down Mitotic spindle assembly 0.001856622 6 NaN NUSAP1;TPX2;TTK
idarubicin Anthracycline Yes Down Mitotic spindle disassembly 0.019671842 15 NaN CDK1
idarubicin Anthracycline Yes Up Necroptosis induction 0.025758645 15.5 NaN TNFRSF1A
idarubicin Anthracycline Yes Down Neuregulin receptor signaling 0.018850561 14 NaN ERBB3;ERBB4
idarubicin Anthracycline Yes Up Nucleotide excision repair 0.002593632 6 NaN DDB2;PCNA;POLH;XPC
idarubicin Anthracycline Yes Up Platelet-derived growth factor receptor signaling 0.031194976 18 NaN PDGFRB;RGS5
idarubicin Anthracycline Yes Up RNA editing 0.001774618 4 NaN A1CF;APOBEC2;APOBEC3C
idarubicin Anthracycline Yes Down Thin myofilament organization 0.007580082 10 NaN ACTA1;TNNI3
idarubicin Anthracycline Yes Up Tropoelastin synthesis 0.025758645 15.5 NaN ELN
idarubicin Anthracycline Yes Down Vesicle tethering at plasma membrane 0.022330855 16.5 NaN EXOC6B;RHOQ
idarubicin Anthracycline Yes Down Z-disc organization 0.038568701 18 NaN ACTN2;PDLIM5
gefitinib Kinase inhibitor No Up Alternative complement pathway 5.59E-05 1 NaN C1S;C3;CFH
gefitinib Kinase inhibitor No Down Antigen presentation via MHC class I molecules 0.030597968 29.5 NaN HLA-B;HLA-C
gefitinib Kinase inhibitor No Down Centrosome maturation 0.004020563 13 NaN AURKA;PLK1;TPX2
gefitinib Kinase inhibitor No Down Centrosome organization 0.012010543 21 NaN ASPM;NEK2;PAX6;TACC3;TUBG1;WDR62
gefitinib Kinase inhibitor No Down Centrosome separation 1.46E-09 1 NaN AURKA;CCNB1;CDK1;ESPL1;KIF11;NEK2;SPAG5
gefitinib Kinase inhibitor No Down Cholesterol synthesis 0.002086621 10 NaN DHCR24;DHCR7;MVK;NSDHL
gefitinib Kinase inhibitor No Up Classical complement pathway 0.006376527 4 NaN C1R;C1S
gefitinib Kinase inhibitor No Down Collagen fibril organization by fibril-associated bridges 0.010986142 19.5 NaN COL9A1;COL9A2
gefitinib Kinase inhibitor No Down Contractile ring constriction 0.000211674 5.5 NaN ANLN;ECT2;MYLK
gefitinib Kinase inhibitor No Up Decorin synthesis 0.017995766 7 NaN DCN
gefitinib Kinase inhibitor No Down Desaturation of fatty acids 0.015096478 22 NaN FADS2;SCD
gefitinib Kinase inhibitor No Down Epithelial intermediate filament dynamics 0.01975769 23.5 NaN KRT19;KRT7
gefitinib Kinase inhibitor No Down Equatorial RhoA activation 0.00456203 15.5 NaN ECT2;KIF23
gefitinib Kinase inhibitor No Down Eukaryotic kinetochore dynamics 8.43E-06 2 NaN BUB1;CENPE;CENPF;NDC80;NUF2;SPC24;TTK;ZWINT
gefitinib Kinase inhibitor No Up Extracellular matrix breakdown and membrane shedding by adamalysins 0.008797024 6 NaN ADAM33;ADAMTS2;ADAMTS5
gefitinib Kinase inhibitor No Down Fibrillar collagen core structure organization 0.030597968 29.5 NaN COL11A1;COL2A1
gefitinib Kinase inhibitor No Up Gap junction organization 0.02543863 8 NaN GJA5;GJB2
gefitinib Kinase inhibitor No Down Glycolysis and Gluconeogenesis 0.003568606 12 NaN ENO1;LDHA;PGAM1;TPI1
gefitinib Kinase inhibitor No Up Hedgehog receptor signaling 0.045084589 10 NaN CDON;GAS1
gefitinib Kinase inhibitor No Up Hepatocyte growth factor receptor signaling 0.035669243 9 NaN HGF
gefitinib Kinase inhibitor No Down Intracellular bridge assembly 0.002324253 11 NaN INCENP;KIF23
gefitinib Kinase inhibitor No Down Lipogenesis 0.000789471 8.5 NaN ACLY;FASN
gefitinib Kinase inhibitor No Down Metaphase to anaphase checkpoint 3.66E-05 4 NaN BUB1;BUB1B;CCNB2;CDC20;CENPE;PTTG1;TTK
gefitinib Kinase inhibitor No Down Mitotic H3 phosphorylation and dephosphorylation 0.000211674 5.5 NaN AURKB;CCNA2;INCENP
gefitinib Kinase inhibitor No Down Mitotic spindle assembly 1.83E-05 3 NaN DLGAP5;NUSAP1;TACC3;TPX2;TTK
gefitinib Kinase inhibitor No Down Mitotic spindle disassembly 0.028140438 26.5 NaN CDK1
gefitinib Kinase inhibitor No Down Natriuretic peptide receptor signaling 0.010986142 19.5 NaN NPPA;NPPB
gefitinib Kinase inhibitor No Down Osteopontin receptor signaling 0.028140438 26.5 NaN SPP1
gefitinib Kinase inhibitor No Down Pyrimidine synthesis and salvage 0.01975769 23.5 NaN TK1;TYMS
gefitinib Kinase inhibitor No Down Retinol metabolism 0.005118789 18 NaN ALDH1A1;ALDH1A3;RPE65
gefitinib Kinase inhibitor No Up Semaphorin signaling 0.003094259 3 NaN NRP2;RND1;SEMA6A;SEMA6D
gefitinib Kinase inhibitor No Up Serine and glycine metabolism 0.000851742 2 NaN PHGDH;PSAT1;SHMT2
gefitinib Kinase inhibitor No Down Sister chromatid attachment to mitotic spindle 0.000789471 8.5 NaN NUF2;TACC3
gefitinib Kinase inhibitor No Down Sister chromatid segregation 0.000414519 7 NaN ESPL1;PTTG1;TOP2A
gefitinib Kinase inhibitor No Down Tenascin receptor signaling 0.00456203 15.5 NaN TENM1;TNC
gefitinib Kinase inhibitor No Down Thrombospondin receptor signaling 0.00456203 15.5 NaN THBS1;THBS4
gefitinib Kinase inhibitor No Down Transmembrane glucose transport 0.00456203 15.5 NaN SLC2A1;SLC2A3
gefitinib Kinase inhibitor No Down Tropoelastin synthesis 0.028140438 26.5 NaN ELN
gefitinib Kinase inhibitor No Down Versican synthesis 0.028140438 26.5 NaN VCAN
gefitinib Kinase inhibitor No Up Water transmembrane transport 0.008401748 5 NaN AQP3;AQP7
flecainide Antiarrhythmic Yes Down Aggrecan synthesis 0.028757939 14 NaN ACAN
flecainide Antiarrhythmic Yes Up Alternative complement pathway 0.002537364 5 NaN C3;CFH
flecainide Antiarrhythmic Yes Down Antigen presentation via MHC class I molecules 0.031852436 18.5 NaN HLA-B;HLA-C
flecainide Antiarrhythmic Yes Down Aspartate and arginine metabolism 0.031852436 18.5 NaN ARG2;SLC7A1
flecainide Antiarrhythmic Yes Up Cellular iron storage 0.047912477 21 NaN FTH1
flecainide Antiarrhythmic Yes Up Centrosome maturation 0.015540411 13 NaN PLK1;TPX2
flecainide Antiarrhythmic Yes Up Centrosome separation 0.010823703 11.5 NaN CDK1;KIF11
flecainide Antiarrhythmic Yes Down Cholesterol synthesis 0.000207154 3 NaN DHCR24;DHCR7;FDFT1;HMGCS1;MSMO1
flecainide Antiarrhythmic Yes Up Collagen fibril organization by fibril-associated bridges 0.003765459 7 NaN COL14A1;COL9A1
flecainide Antiarrhythmic Yes Down Connection of muscle sarcomere to plasma membrane 0.031852436 18.5 NaN ANK3;TLN2
flecainide Antiarrhythmic Yes Up Decorin synthesis 0.016231475 14.5 NaN DCN
flecainide Antiarrhythmic Yes Down ER unfolded protein response pathway 0.020584442 10 NaN ATF4;HERPUD1
flecainide Antiarrhythmic Yes Up Eukaryotic kinetochore dynamics 1.33E-07 1 NaN BUB1;CENPE;CENPF;CENPU;MAD2L1;NDC80;NUF2;TTK
flecainide Antiarrhythmic Yes Down Extracellular matrix breakdown and membrane shedding by adamalysins 0.03050589 16 NaN ADAMTS1;ADAMTS12;ADAMTS14
flecainide Antiarrhythmic Yes Up Extracellular matrix breakdown by matrix metalloproteases 0.008751803 10 NaN MMP1;MMP2
flecainide Antiarrhythmic Yes Down Extracellular matrix breakdown by matrix metalloproteases 0.025968562 12 NaN MMP12;MMP3
flecainide Antiarrhythmic Yes Up Fibrillar collagen core structure organization 0.010823703 11.5 NaN COL1A1;COL3A1
flecainide Antiarrhythmic Yes Down Fibrillar collagen core structure organization 0.031852436 18.5 NaN COL11A1;COL5A1
flecainide Antiarrhythmic Yes Up Folate cycle 0.047912477 21 NaN DHFR
flecainide Antiarrhythmic Yes Down Glycolysis and Gluconeogenesis 3.60E-05 1 NaN ENO1;HK2;LDHA;PCK2;PFKFB3;PFKFB4
flecainide Antiarrhythmic Yes Up Granulocyte macrophage colony-stimulating factor receptor signaling 0.032200898 18 NaN JUND
flecainide Antiarrhythmic Yes Up Hepatocyte growth factor receptor signaling 0.032200898 18 NaN HGF
flecainide Antiarrhythmic Yes Down Inhibin receptor signaling 0.020584442 10 NaN INHBE;TGFBR3
flecainide Antiarrhythmic Yes Down Interferon alpha receptor signaling 0.020584442 10 NaN IRF9;STAT1
flecainide Antiarrhythmic Yes Down JAK-STAT signaling pathway 0.00677632 7 NaN SOCS3;STAT1;USP18
flecainide Antiarrhythmic Yes Up Metaphase to anaphase checkpoint 0.002129332 4 NaN BUB1;CENPE;MAD2L1;TTK
flecainide Antiarrhythmic Yes Up Mitotic spindle assembly 1.24E-06 2 NaN CKAP2;DLGAP5;NUSAP1;TPX2;TTK
flecainide Antiarrhythmic Yes Up Mitotic spindle disassembly 0.016231475 14.5 NaN CDK1
flecainide Antiarrhythmic Yes Down Natriuretic peptide receptor signaling 0.011455252 8 NaN NPPA;NPPB
flecainide Antiarrhythmic Yes Up Nuclear envelope maintenance 0.003765459 7 NaN LMNB1;TMPO
flecainide Antiarrhythmic Yes Up Nuclear intermediate filaments 0.003765459 7 NaN LMNB1;TMPO
flecainide Antiarrhythmic Yes Up Osteonectin receptor signaling 0.00153885 3 NaN SMOC2;SPARC
flecainide Antiarrhythmic Yes Down Osteopontin receptor signaling 0.028757939 14 NaN SPP1
flecainide Antiarrhythmic Yes Up Pyrimidine synthesis and salvage 0.006880038 9 NaN TK1;TYMS
flecainide Antiarrhythmic Yes Up Retinol metabolism 0.018171887 16 NaN ALDH1A2;RDH10
flecainide Antiarrhythmic Yes Down Retinol metabolism 0.00543886 6 NaN ALDH1A1;STRA6;TTR
flecainide Antiarrhythmic Yes Up Ribonucleotide reduction 0.047912477 21 NaN RRM2
flecainide Antiarrhythmic Yes Down Serine and glycine metabolism 0.000188817 2 NaN PHGDH;PSAT1;SHMT2;SLC1A5
flecainide Antiarrhythmic Yes Up Sister chromatid attachment to mitotic spindle 0.032200898 18 NaN NUF2
flecainide Antiarrhythmic Yes Down Tenascin receptor signaling 0.004760776 4.5 NaN TENM1;TNC
flecainide Antiarrhythmic Yes Down Transmembrane glucose transport 0.004760776 4.5 NaN SLC2A1;SLC2A3
flecainide Antiarrhythmic Yes Down Tropoelastin synthesis 0.028757939 14 NaN ELN
estradiol Female sex hormone No Down Adherens junction organization 0.038033595 18 NaN CDH1;CDH3;CDH5
estradiol Female sex hormone No Up Albumin mediated blood protein transport 0.026199718 13 NaN ALB
estradiol Female sex hormone No Down Alternative complement pathway 0.003169819 7 NaN C3;CFH
estradiol Female sex hormone No Up Axonal intermediate filament dynamics 0.000576244 2 NaN NEFH;NEFL;NEFM
estradiol Female sex hormone No Down CCN intercellular signaling protein family receptor signaling 0.003169819 7 NaN CTGF;CYR61
estradiol Female sex hormone No Down Collagen fiber crosslinking 0.003169819 7 NaN LOXL1;PXDN
estradiol Female sex hormone No Up Collagen fibril organization by fibril-associated bridges 0.009570814 7.5 NaN COL9A2;COL9A3
estradiol Female sex hormone No Up Contractile ring constriction 0.006492473 6 NaN MYH14;MYLK
estradiol Female sex hormone No Down Decorin synthesis 0.018172195 13.5 NaN DCN
estradiol Female sex hormone No Down Epithelial intermediate filament dynamics 7.00E-06 1 NaN KRT19;KRT4;KRT7;TCHH
estradiol Female sex hormone No Up Extracellular matrix breakdown and membrane shedding by adamalysins 0.023986054 10 NaN ADAM12;ADAM33;ADAMTS5
estradiol Female sex hormone No Down Fibrillar collagen core structure organization 2.04E-05 2 NaN COL1A2;COL2A1;COL3A1;COL5A2
estradiol Female sex hormone No Up Fibroblast growth factor receptor signaling 0.003285666 3 NaN FGF10;FGF18;FGFR3
estradiol Female sex hormone No Up Growth differentiation factor receptor signaling 0.01725681 9 NaN GDF2;GDF6
estradiol Female sex hormone No Down Heme synthesis 0.045884436 19 NaN ABCG2;ALAS2
estradiol Female sex hormone No Up Inhibition of amyloid aggregation, amyloid degradation and uptake 1.78E-05 1 NaN A2M;MME;PLAT
estradiol Female sex hormone No Down Integrin-mediated leukocyte rolling 0.006498634 11.5 NaN ICAM1;VCAM1
estradiol Female sex hormone No Down Methionine cycle 0.036015735 16.5 NaN BHMT
estradiol Female sex hormone No Down Microtubule crosslinking and bundling 0.004697925 9.5 NaN MAP2;MTCL1
estradiol Female sex hormone No Down Natriuretic peptide receptor signaling 0.000113608 3 NaN NPPA;NPPB;NPR1
estradiol Female sex hormone No Up Osteonectin receptor signaling 0.003963971 4 NaN SMOC2;SPOCK1
estradiol Female sex hormone No Up Osteopontin receptor signaling 0.026199718 13 NaN SPP1
estradiol Female sex hormone No Up Platelet-derived growth factor receptor signaling 0.032189046 15 NaN PDGFRA;RGS5
estradiol Female sex hormone No Up Progesterone receptor signaling 0.026199718 13 NaN PGR
estradiol Female sex hormone No Up Prostaglandin E2 receptor signaling 0.009570814 7.5 NaN PTGER3;RAPGEF4
estradiol Female sex hormone No Up Retinol metabolism 0.004189215 5 NaN ALDH1A1;RDH10;RPE65
estradiol Female sex hormone No Down Retinol metabolism 0.02246927 15 NaN ALDH1A2;DHRS3
estradiol Female sex hormone No Down Selectin-mediated Leukocyte rolling 0.004697925 9.5 NaN ICAM1;VCAM1
estradiol Female sex hormone No Down Serine and glycine metabolism 0.000876231 4 NaN PHGDH;PSAT1;SHMT2
estradiol Female sex hormone No Down Sister chromatid attachment to mitotic spindle 0.036015735 16.5 NaN TACC3
estradiol Female sex hormone No Down Thin myofilament organization 0.006498634 11.5 NaN ACTA1;TNNI3
estradiol Female sex hormone No Down Tropoelastin synthesis 0.018172195 13.5 NaN ELN
estradiol Female sex hormone No Up WNT-Beta-catenin signaling pathway 0.025887605 11 NaN APCDD1;DKK2;FRZB;PAX6;WNT9A
estradiol Female sex hormone No Down Z-disc organization 0.002781024 5 NaN DES;LDB3;PDLIM3
erlotinib Kinase inhibitor No Up Androgen receptor signaling 0.024374358 9 NaN AR
erlotinib Kinase inhibitor No Up Aspartate and arginine metabolism 0.006298081 3 NaN ARG2;SLC7A1
erlotinib Kinase inhibitor No Down CCN intercellular signaling protein family receptor signaling 0.010319741 26.5 NaN CTGF;CYR61
erlotinib Kinase inhibitor No Up CD44-Mediated leukocyte rolling 0.024374358 9 NaN CD44
erlotinib Kinase inhibitor No Up Cellular iron storage 0.036339415 13.5 NaN FTL
erlotinib Kinase inhibitor No Down Centrosome maturation 0.006418182 22.5 NaN AURKA;PLK1;TPX2
erlotinib Kinase inhibitor No Down Centrosome organization 0.001796506 14 NaN ASPM;NEK2;PLK3;PLK4;POC1A;STIL;TACC3;WDR62
erlotinib Kinase inhibitor No Down Centrosome separation 4.69E-09 3 NaN AURKA;CCNB1;CDK1;ESPL1;KIF11;NEK2;SPAG5
erlotinib Kinase inhibitor No Up Class switch recombination 0.022270657 7 NaN BCL6;IL7R
erlotinib Kinase inhibitor No Down Collagen fiber crosslinking 0.010319741 26.5 NaN LOX;LOXL1
erlotinib Kinase inhibitor No Down Contractile ring constriction 0.000347172 8.5 NaN ANLN;ECT2;MYLK
erlotinib Kinase inhibitor No Up Discoidin domain receptor signaling 0.036339415 13.5 NaN DDR2
erlotinib Kinase inhibitor No Down DNA replication elongation 3.96E-08 4 NaN MCM2;MCM4;MCM5;MCM7;PCNA
erlotinib Kinase inhibitor No Down DNA replication initiation 1.80E-13 1 NaN CDC45;CDC6;GINS1;GINS2;GINS4;MCM10;MCM2;MCM3;MCM4;MCM5;MCM6;MCM7;ORC6
erlotinib Kinase inhibitor No Down Elastin cross-linking and assembly 0.003236551 17 NaN LOX;LOXL1
erlotinib Kinase inhibitor No Down Epithelial intermediate filament dynamics 0.001804023 15 NaN KRT19;KRT7;KRT8
erlotinib Kinase inhibitor No Down Equatorial RhoA activation 0.006330714 20 NaN ECT2;KIF23
erlotinib Kinase inhibitor No Up ER unfolded protein response pathway 1.46E-06 2 NaN ATF4;DDIT3;HERPUD1;PPP1R15A
erlotinib Kinase inhibitor No Down Eukaryotic kinetochore dynamics 3.94E-13 2 NaN BUB1;CENPE;CENPF;CENPH;CENPI;CENPU;CENPW;KIF15;MAD2L1;NDC80;NUF2;SKA3;SPC24;TTK;ZWINT
erlotinib Kinase inhibitor No Down Fanconi anemia interstrand cross-link repair pathway 0.000170094 7 NaN BRCA2;BRIP1;FANCA;FANCD2;FANCI;UBE2T
erlotinib Kinase inhibitor No Down G2 M transition checkpoint 0.006418182 22.5 NaN CCNB1;CDC25C;CDK1
erlotinib Kinase inhibitor No Up Glutamate and glutamine metabolism 0.010657121 5 NaN SLC1A5;SLC7A5
erlotinib Kinase inhibitor No Up Heme degradation to bilirubin 0.036339415 13.5 NaN HMOX1
erlotinib Kinase inhibitor No Down Homologous recombination DSB repair 0.000743214 11 NaN BRCA2;EXO1;PIF1;RAD51AP1;RECQL4;RMI2;XRCC2
erlotinib Kinase inhibitor No Up Hyaluronan receptor CD44 signaling 0.036339415 13.5 NaN CD44
erlotinib Kinase inhibitor No Down Intracellular bridge assembly 0.003236551 17 NaN INCENP;KIF23
erlotinib Kinase inhibitor No Up Mammalian target of rapamycin signaling pathway 0.01799692 6 NaN DDIT4;EIF4EBP1
erlotinib Kinase inhibitor No Down Metaphase to anaphase checkpoint 1.14E-06 5 NaN BUB1;BUB1B;CCNB2;CDC20;CENPE;MAD2L1;PLK3;PTTG1;TTK
erlotinib Kinase inhibitor No Down Mitotic chromosome condensation 0.001155937 13 NaN INCENP;NCAPG2;SMC4
erlotinib Kinase inhibitor No Down Mitotic H3 phosphorylation and dephosphorylation 0.000347172 8.5 NaN AURKB;CCNA2;INCENP
erlotinib Kinase inhibitor No Down Mitotic spindle assembly 4.09E-05 6 NaN DLGAP5;NUSAP1;TACC3;TPX2;TTK
erlotinib Kinase inhibitor No Up Neuregulin receptor signaling 0.007636099 4 NaN ERBB3;ERBB4
erlotinib Kinase inhibitor No Up Potassium transmembrane transport 0.034546233 11 NaN ABCC9;ATP1A3
erlotinib Kinase inhibitor No Down Retinol metabolism 0.008140214 24 NaN ALDH1A1;ALDH1A3;RBP1
erlotinib Kinase inhibitor No Down Ribonucleotide reduction 0.003236551 17 NaN RRM1;RRM2
erlotinib Kinase inhibitor No Up Serine and glycine metabolism 1.12E-07 1 NaN PHGDH;PSAT1;PSPH;SHMT2;SLC1A5
erlotinib Kinase inhibitor No Down Sister chromatid attachment to mitotic spindle 0.001103184 12 NaN NUF2;TACC3
erlotinib Kinase inhibitor No Down Sister chromatid cohesion 0.010080538 25 NaN CDCA5;CHTF18;ESCO2;WDHD1
erlotinib Kinase inhibitor No Down Sister chromatid segregation 0.000677215 10 NaN ESPL1;PTTG1;TOP2A
erlotinib Kinase inhibitor No Down Telomere replication and maintenance 0.014805151 28 NaN EXO1;PIF1;RECQL4
erlotinib Kinase inhibitor No Down Tenascin receptor signaling 0.006330714 20 NaN TENM1;TNC
erlotinib Kinase inhibitor No Down Thrombospondin receptor signaling 0.006330714 20 NaN THBS2;THBS4
erlotinib Kinase inhibitor No Up Vasoactive intestinal peptide receptor signaling 0.024374358 9 NaN VIPR1
epirubicin Anthracycline Yes Up Actin filament severing and depolymerization 0.001294662 9 NaN CFL1;CFL2;DSTN;GSN
epirubicin Anthracycline Yes Up Albumin mediated blood protein transport 0.039520113 25.5 NaN ALB
epirubicin Anthracycline Yes Up Amination of alpha-keto acids and deamination of amino acids 0.008867547 15 NaN GLUD1;LOXL2
epirubicin Anthracycline Yes Up Amyloid plaque organization 0.00063643 5 NaN APOE;APP;HSPB6;SNCA
epirubicin Anthracycline Yes Up Antigen presentation via MHC class I molecules 0.000418001 4 NaN B2M;HLA-A;HLA-B;HLA-C
epirubicin Anthracycline Yes Up Basement membrane attachment to cell surface 3.39E-05 3 NaN BCAM;BSG;CD151;NID1
epirubicin Anthracycline Yes Up Beta-oxidation 0.002999064 11 NaN ACADM;ACADVL;DECR1;HADH
epirubicin Anthracycline Yes Up Biglycan synthesis 0.039520113 25.5 NaN BGN
epirubicin Anthracycline Yes Up Chaperone mediated protein folding in ER 0.042412632 30 NaN ERP29;FKBP10;PDIA3
epirubicin Anthracycline Yes Up Collagen fibril organization by fibril-associated bridges 0.021030373 19.5 NaN COL9A1;COL9A3
epirubicin Anthracycline Yes Up Contractile ring constriction 0.014394098 17.5 NaN CDC42;MYLK
epirubicin Anthracycline Yes Up Cytosolic protein folding 0.039520113 25.5 NaN HSP90AA1
epirubicin Anthracycline Yes Up Decorin synthesis 0.039520113 25.5 NaN DCN
epirubicin Anthracycline Yes Up Extracellular matrix breakdown by cathepsins 2.02E-05 2 NaN CTSB;CTSF;CTSL;CTSV;CTSZ
epirubicin Anthracycline Yes Up Fibrillar collagen core structure organization 1.56E-08 1 NaN COL11A2;COL1A1;COL1A2;COL2A1;COL3A1;COL5A1;COL5A2
epirubicin Anthracycline Yes Up Fibulin receptor signaling 0.001558491 10 NaN EFEMP2;FBLN1
epirubicin Anthracycline Yes Down Glycogen synthesis and glycogenolysis 0.003151912 2 NaN PPP1R3B;PPP1R3C
epirubicin Anthracycline Yes Up GPI-anchor synthesis and attachment to protein 0.000924994 6.5 NaN GPAA1;PIGK;PIGS;PIGT
epirubicin Anthracycline Yes Up G-protein coupled receptor signaling pathway 0.042412632 30 NaN GNAS;RGS16;RGS5
epirubicin Anthracycline Yes Down Granulocyte macrophage colony-stimulating factor receptor signaling 0.010558195 3 NaN JUND
epirubicin Anthracycline Yes Up Ketone body metabolism 0.039520113 25.5 NaN OXCT1
epirubicin Anthracycline Yes Up Lipid droplet mitochondria interaction 0.004552817 12 NaN SCP2;SNAP23
epirubicin Anthracycline Yes Up Lysosomal acidification 0.008867547 15 NaN ATP6AP1;ATP6AP2
epirubicin Anthracycline Yes Up Lysosomal glycosaminoglycan degradation 0.000924994 6.5 NaN ARSB;GNS;IDS;SUMF1
epirubicin Anthracycline Yes Up Lysosomal lipid degradation 0.001121548 8 NaN GALC;HEXA;PSAP
epirubicin Anthracycline Yes Up Macroautophagy 0.042412632 30 NaN BECN1;MAP1LC3A;MAP1LC3B
epirubicin Anthracycline Yes Down Macrophage migration inhibitory factor signaling 0.026190267 4 NaN JUND
epirubicin Anthracycline Yes Down Myelin biogenesis and maturation 0.031346792 5 NaN PMP22
epirubicin Anthracycline Yes Down Myofibril formation 0.001206358 1 NaN KLHL41;XIRP1
epirubicin Anthracycline Yes Up Natriuretic peptide receptor signaling 0.021030373 19.5 NaN NPPA;NPPB
epirubicin Anthracycline Yes Up Non-vesicular phospholipid transport 0.028680422 22 NaN PITPNM1;SCP2
epirubicin Anthracycline Yes Up Phase I biotransformation via alcohol dehydrogenases 0.008867547 15 NaN ALDH2;ALDH9A1
epirubicin Anthracycline Yes Up Protein N-linked glycosylation in ER 0.007980244 13 NaN DDOST;RPN2;TUSC3
epirubicin Anthracycline Yes Up Protein polyubiquitination 0.023395932 21 NaN NEDD8;SKP1;UCHL1
epirubicin Anthracycline Yes Down Retrograde vesicle traffic from Golgi to ER 0.046655803 6 NaN COPB1
epirubicin Anthracycline Yes Up Syndecan receptor signaling 0.014394098 17.5 NaN SDC4;SDCBP
epirubicin Anthracycline Yes Up Tropoelastin synthesis 0.039520113 25.5 NaN ELN
endothelin-1 Endogenous vasoconstrictor No Up Actin filament bundling and crosslinking 0.027648786 17 NaN PLS3;SYNPO2;TAGLN
endothelin-1 Endogenous vasoconstrictor No Up Aggrecan synthesis 0.025494001 15 NaN ACAN
endothelin-1 Endogenous vasoconstrictor No Up Albumin mediated blood protein transport 0.025494001 15 NaN ALB
endothelin-1 Endogenous vasoconstrictor No Down Alternative complement pathway 0.003737436 7.5 NaN C3;CFH
endothelin-1 Endogenous vasoconstrictor No Up Amyloid plaque organization 0.030604726 18 NaN APBB2;APOE
endothelin-1 Endogenous vasoconstrictor No Up Antigen presentation via MHC class I molecules 0.025462828 13 NaN HLA-B;HLA-C
endothelin-1 Endogenous vasoconstrictor No Down Biglycan synthesis 0.019760056 12 NaN BGN
endothelin-1 Endogenous vasoconstrictor No Down Calcitonin receptor signaling 0.039131362 18.5 NaN RAMP1
endothelin-1 Endogenous vasoconstrictor No Down CD44-Mediated leukocyte rolling 0.039131362 18.5 NaN CD44
endothelin-1 Endogenous vasoconstrictor No Down Cellular cholesterol uptake and efflux 0.001880573 6 NaN ABCA1;ABCG1;SCARA3
endothelin-1 Endogenous vasoconstrictor No Down Cellular iron storage 0.001151024 5 NaN FTH1;FTL
endothelin-1 Endogenous vasoconstrictor No Up Centrosome maturation 0.036117476 19.5 NaN PLK1;TPX2
endothelin-1 Endogenous vasoconstrictor No Up Centrosome separation 7.70E-05 3 NaN CCNB1;CDK1;KIF11;NEK2
endothelin-1 Endogenous vasoconstrictor No Down Chaperone-mediated autophagy 0.039131362 18.5 NaN HSPA8
endothelin-1 Endogenous vasoconstrictor No Up Cholesterol synthesis 5.28E-10 1 NaN CYP51A1;DHCR24;DHCR7;FDFT1;FDPS;HMGCR;HMGCS1;MSMO1;MVD
endothelin-1 Endogenous vasoconstrictor No Up Classical complement pathway 1.36E-05 2 NaN C1QA;C1QB;C1QC;C1R
endothelin-1 Endogenous vasoconstrictor No Up Collagen fiber crosslinking 0.006155642 9 NaN LOXL1;PXDN
endothelin-1 Endogenous vasoconstrictor No Down Collagen fibril organization by fibril-associated bridges 0.000145711 2 NaN COL12A1;COL14A1;COL9A2
endothelin-1 Endogenous vasoconstrictor No Down Decorin synthesis 0.019760056 12 NaN DCN
endothelin-1 Endogenous vasoconstrictor No Down Endogenous control of complement activity 0.003737436 7.5 NaN CFH;CFI
endothelin-1 Endogenous vasoconstrictor No Up Eukaryotic kinetochore dynamics 0.000361948 6 NaN BUB1;CENPE;CENPF;DYNLT3;SPC24;ZWINT
endothelin-1 Endogenous vasoconstrictor No Down Extracellular matrix breakdown by cathepsins 0.015757014 10 NaN CTSF;CTSH
endothelin-1 Endogenous vasoconstrictor No Up Fibrillar collagen core structure organization 0.001722716 7 NaN COL11A2;COL2A1;COL5A1
endothelin-1 Endogenous vasoconstrictor No Down Fibrillar collagen core structure organization 2.84E-05 1 NaN COL1A1;COL1A2;COL3A1;COL5A2
endothelin-1 Endogenous vasoconstrictor No Up G2 M transition checkpoint 0.036117476 19.5 NaN CCNB1;CDK1
endothelin-1 Endogenous vasoconstrictor No Up Glycolysis and Gluconeogenesis 0.00024 4 NaN ALDOA;ENO1;LDHA;PGK1;TPI1
endothelin-1 Endogenous vasoconstrictor No Up Growth differentiation factor receptor signaling 0.016384625 11.5 NaN GDF2;GDF6
endothelin-1 Endogenous vasoconstrictor No Down Hepatocyte growth factor receptor signaling 0.039131362 18.5 NaN MET
endothelin-1 Endogenous vasoconstrictor No Up Inhibition of apoptosis 0.003040976 8 NaN BIRC5;IFI6;XAF1
endothelin-1 Endogenous vasoconstrictor No Up JAK-STAT signaling pathway 0.048167963 22 NaN SOCS2;STAT1
endothelin-1 Endogenous vasoconstrictor No Down Methionine cycle 0.039131362 18.5 NaN BHMT
endothelin-1 Endogenous vasoconstrictor No Down Microfibril scaffold organization 0.039131362 18.5 NaN FBN1
endothelin-1 Endogenous vasoconstrictor No Up Mitotic spindle assembly 0.041978966 21 NaN NUSAP1;TPX2
endothelin-1 Endogenous vasoconstrictor No Up Mitotic spindle disassembly 0.025494001 15 NaN CDK1
endothelin-1 Endogenous vasoconstrictor No Up Natriuretic peptide receptor signaling 0.000309793 5 NaN NPPA;NPPB;NPR3
endothelin-1 Endogenous vasoconstrictor No Down Parathyroid hormone receptor signaling 0.007646107 9 NaN PTHLH;SLC9A3R1
endothelin-1 Endogenous vasoconstrictor No Down Platelet-derived growth factor receptor signaling 0.001117129 3.5 NaN FOSL1;PDGFRA;PDGFRB
endothelin-1 Endogenous vasoconstrictor No Up Prostaglandin E2 receptor signaling 0.009078567 10 NaN PTGER3;RAPGEF4
endothelin-1 Endogenous vasoconstrictor No Down Protein polyubiquitination 0.038884414 15 NaN UBC;UCHL1
endothelin-1 Endogenous vasoconstrictor No Up Pyrimidine synthesis and salvage 0.016384625 11.5 NaN TK1;TYMP
endothelin-1 Endogenous vasoconstrictor No Down Retinol metabolism 0.026271217 14 NaN ALDH1A1;ALDH1A3
endothelin-1 Endogenous vasoconstrictor No Down Serine and glycine metabolism 0.001117129 3.5 NaN PHGDH;PSAT1;SHMT2
endothelin-1 Endogenous vasoconstrictor No Down Tropoelastin synthesis 0.019760056 12 NaN ELN
doxorubicin Anthracycline Yes Down Apoptosome assembly 0.024461509 11 NaN BAG3
doxorubicin Anthracycline Yes Down Axonal intermediate filament dynamics 0.034080706 15 NaN NEFM
doxorubicin Anthracycline Yes Up Cardiomyocyte pacemaker current generation 0.03076651 11 NaN CACNA1G;KCNJ5
doxorubicin Anthracycline Yes Down CD44-Mediated leukocyte rolling 0.009856058 5.5 NaN CD44
doxorubicin Anthracycline Yes Down Cellular iron storage 0.014748246 8 NaN FTL
doxorubicin Anthracycline Yes Down Chaperone-mediated autophagy 2.40E-05 1 NaN HSP90AA1;HSPA8
doxorubicin Anthracycline Yes Up Contractile ring constriction 0.011795627 4.5 NaN ANLN;MYLK
doxorubicin Anthracycline Yes Down Contractile ring constriction 0.024461509 11 NaN MYH14
doxorubicin Anthracycline Yes Down Contractile ring formation 0.024461509 11 NaN MYH14
doxorubicin Anthracycline Yes Down Cytosolic protein folding 0.004940014 4 NaN HSP90AA1
doxorubicin Anthracycline Yes Down ER unfolded protein response pathway 0.038855309 16 NaN DDIT3
doxorubicin Anthracycline Yes Down Extracellular matrix breakdown by matrix metalloproteases 0.043606731 17 NaN MMP1
doxorubicin Anthracycline Yes Up Extracellular matrix breakdown by serine proteases 0.023625158 9.5 NaN HTRA1;ST14
doxorubicin Anthracycline Yes Up Extrinsic apoptosis pathway 0.023625158 9.5 NaN TNFRSF10A;TNFRSF10B
doxorubicin Anthracycline Yes Up Gap junction organization 0.012201709 6 NaN GJA5;GJB2;PRKCG
doxorubicin Anthracycline Yes Down Heme degradation to bilirubin 0.014748246 8 NaN HMOX1
doxorubicin Anthracycline Yes Down Hepatocyte growth factor receptor signaling 0.009856058 5.5 NaN MET
doxorubicin Anthracycline Yes Down Hyaluronan receptor CD44 signaling 0.014748246 8 NaN CD44
doxorubicin Anthracycline Yes Up Lipid droplet fusion 0.035638673 13 NaN CIDEC
doxorubicin Anthracycline Yes Down Microtubule crosslinking and bundling 0.02928281 13.5 NaN MAP2
doxorubicin Anthracycline Yes Down Mitochondrial transport 0.048335081 18 NaN KIF1A
doxorubicin Anthracycline Yes Up Mitotic spindle disassembly 0.035638673 13 NaN CDK1
doxorubicin Anthracycline Yes Up Muscarinic receptor signaling 0.017278804 7.5 NaN CHRM4;RGS5
doxorubicin Anthracycline Yes Up Natriuretic peptide receptor signaling 0.017278804 7.5 NaN NPPA;NPPC
doxorubicin Anthracycline Yes Down NFkB signaling pathway 0.02928281 13.5 NaN SQSTM1
doxorubicin Anthracycline Yes Up Nucleosome assembly 0.000893891 2 NaN ASF1B;BAZ1A;HIST1H1D;HIST1H1E;HIST2H2BE
doxorubicin Anthracycline Yes Down Proteasomal regulatory particle organization 0.000495433 2 NaN PSMC4;PSMD14
doxorubicin Anthracycline Yes Down Protein polyubiquitination 0.002751374 3 NaN UBC;UCHL1
doxorubicin Anthracycline Yes Up Syndecan receptor signaling 0.011795627 4.5 NaN SDC1;SDC4
doxorubicin Anthracycline Yes Up Thick myofilament organization 0.003711366 3 NaN MYBPC3;MYH7
doxorubicin Anthracycline Yes Up Tropoelastin synthesis 0.035638673 13 NaN ELN
doxorubicin Anthracycline Yes Up WNT-Beta-catenin signaling pathway 0.000410988 1 NaN APCDD1;DKK2;DKK3;FZD1;FZD7;FZD8;LEF1;MSX2;SFRP5
dobutamine Sympathomimetic No Up Actin filament bundling and crosslinking 0.000247349 1 NaN EPS8;FLNA;FSCN2;TAGLN;USH1C
dobutamine Sympathomimetic No Down Aggrecan synthesis 0.022141849 8.5 NaN ACAN
dobutamine Sympathomimetic No Down Albumin mediated blood protein transport 0.022141849 8.5 NaN ALB
dobutamine Sympathomimetic No Down Bicarbonate transmembrane transport 0.007994779 5 NaN CA2;CA9;SLC4A8
dobutamine Sympathomimetic No Up Biglycan synthesis 0.022494707 8.5 NaN BGN
dobutamine Sympathomimetic No Up Collagen fibril organization by fibril-associated bridges 0.007122126 5 NaN COL12A1;COL9A1
dobutamine Sympathomimetic No Down Extracellular matrix breakdown by cathepsins 0.019543779 7 NaN CTSF;CTSZ
dobutamine Sympathomimetic No Up Extracellular matrix breakdown by matrix metalloproteases 0.000854681 2 NaN MMP12;MMP2;MMP3
dobutamine Sympathomimetic No Up Extracellular matrix breakdown by serine proteases 0.00982368 6 NaN HTRA1;KLK5
dobutamine Sympathomimetic No Up Fibrillar collagen core structure organization 0.001200742 3 NaN COL11A2;COL2A1;COL5A2
dobutamine Sympathomimetic No Down Fibrillar collagen core structure organization 4.44E-05 1 NaN COL1A1;COL1A2;COL3A1;COL5A3
dobutamine Sympathomimetic No Down Granulocyte macrophage colony-stimulating factor receptor signaling 0.043795347 12 NaN JUND
dobutamine Sympathomimetic No Down Hepatocyte growth factor receptor signaling 0.000488351 3 NaN HGF;MET
dobutamine Sympathomimetic No Up JAK-STAT signaling pathway 0.03838784 13 NaN SOCS2;STAT4
dobutamine Sympathomimetic No Up Methionine cycle 0.044485342 14.5 NaN BHMT
dobutamine Sympathomimetic No Down Microfibril scaffold organization 0.043795347 12 NaN FBN1
dobutamine Sympathomimetic No Down Mineralocorticoid receptor signaling 0.043795347 12 NaN GPER1
dobutamine Sympathomimetic No Up Osteopontin receptor signaling 0.022494707 8.5 NaN SPP1
dobutamine Sympathomimetic No Up Platelet-derived growth factor receptor signaling 0.024248529 11 NaN FOSL1;PDGFRB
dobutamine Sympathomimetic No Up Polyol pathway 0.002935166 4 NaN AKR1B1;AKR1B10
dobutamine Sympathomimetic No Down Removal of caspase inhibition 0.043795347 12 NaN XAF1
dobutamine Sympathomimetic No Up Retinol metabolism 0.033390636 12 NaN RPE65;STRA6
dobutamine Sympathomimetic No Down Retinol metabolism 0.000143348 2 NaN ALDH1A3;CYP26A1;DHRS3;RBP1
dobutamine Sympathomimetic No Down Serotonin inactivation 0.043795347 12 NaN MAOB
dobutamine Sympathomimetic No Down Thin myofilament organization 0.009528592 6 NaN LMOD3;TPM4
dobutamine Sympathomimetic No Down Thrombospondin receptor signaling 0.002844982 4 NaN THBS2;THBS4
dobutamine Sympathomimetic No Up Tropoelastin synthesis 0.022494707 8.5 NaN ELN
dobutamine Sympathomimetic No Up Versican receptor signaling 0.044485342 14.5 NaN VCAN
dobutamine Sympathomimetic No Up Versican synthesis 0.022494707 8.5 NaN VCAN
diclofenac Nsaid No Up Aggrecan synthesis 0.024170783 14 NaN ACAN
diclofenac Nsaid No Up Alternative complement pathway 0.005547025 6 NaN C1S;C3
diclofenac Nsaid No Down Amyloid plaque organization 0.02047443 3.5 NaN APOE;HSPB6
diclofenac Nsaid No Up Androgen receptor signaling 0.047759421 17.5 NaN AR
diclofenac Nsaid No Down Antigen presentation via MHC class I molecules 0.016979423 2 NaN HLA-B;HLA-C
diclofenac Nsaid No Down Biglycan synthesis 0.020553987 6 NaN BGN
diclofenac Nsaid No Up Cardiomyocyte pacemaker current generation 0.014803768 11 NaN CACNA1G;KCNK2
diclofenac Nsaid No Up Cardiomyocyte repolarization during action potential and hyperpolarization 0.004172266 4 NaN KCNA1;KCNA4;KCNIP2
diclofenac Nsaid No Up CCN intercellular signaling protein family receptor signaling 0.005547025 6 NaN CTGF;CYR61
diclofenac Nsaid No Down Cholesterol-sensitive control of SREBP activation 0.005975135 1 NaN INSIG1;SREBF1
diclofenac Nsaid No Up Classical complement pathway 0.011281532 9.5 NaN C1R;C1S
diclofenac Nsaid No Up Collagen fibril organization by fibril-associated bridges 4.82E-06 1 NaN COL12A1;COL14A1;COL19A1;COL9A3
diclofenac Nsaid No Down Decorin synthesis 0.020553987 6 NaN DCN
diclofenac Nsaid No Up Fibrillar collagen core structure organization 0.023046241 12 NaN COL2A1;COL5A3
diclofenac Nsaid No Up Fibulin receptor signaling 0.047759421 17.5 NaN FBLN1
diclofenac Nsaid No Down Glutamate and glutamine metabolism 0.028265172 8.5 NaN SLC1A5;SLC7A5
diclofenac Nsaid No Up Hepatocyte growth factor receptor signaling 0.047759421 17.5 NaN HGF
diclofenac Nsaid No Down Lipogenesis 0.040687284 10.5 NaN FASN
diclofenac Nsaid No Down Methionine cycle 0.040687284 10.5 NaN BHMT
diclofenac Nsaid No Up Microfibril scaffold organization 0.047759421 17.5 NaN FBN1
diclofenac Nsaid No Down Mitotic spindle assembly 0.028265172 8.5 NaN NUSAP1;TPX2
diclofenac Nsaid No Up Natriuretic peptide receptor signaling 0.008188205 8 NaN NPPB;NPR3
diclofenac Nsaid No Down Osteopontin receptor signaling 0.020553987 6 NaN SPP1
diclofenac Nsaid No Up Perlecan synthesis 0.024170783 14 NaN HSPG2
diclofenac Nsaid No Up Platelet-derived growth factor receptor signaling 0.001995643 2 NaN PDGFRB;RGS5;TNK2
diclofenac Nsaid No Down Platelet-derived growth factor receptor signaling 0.02047443 3.5 NaN FOSL1;PDGFRA
diclofenac Nsaid No Up Progesterone receptor signaling 0.024170783 14 NaN PGR
diclofenac Nsaid No Up Roundabout signaling 0.011281532 9.5 NaN ROBO1;ROBO2
diclofenac Nsaid No Up Sulfonation 0.005547025 6 NaN SULT1A1;SULT1E1
diclofenac Nsaid No Up Thrombospondin receptor signaling 0.003382112 3 NaN CD47;THBS2
diclofenac Nsaid No Down WNT-Beta-catenin signaling pathway 0.04239236 13 NaN FRAT1;FRZB;PAX6;SFRP5
diclofenac Nsaid No Down Z-disc organization 0.041771182 12 NaN DES;TCAP
delavirdine Antiviral No Down Albumin mediated blood protein transport 0.027081863 11.5 NaN ALB
delavirdine Antiviral No Up Alternative complement pathway 0.003079589 4.5 NaN C1S;CFH
delavirdine Antiviral No Down Biglycan synthesis 0.027081863 11.5 NaN BGN
delavirdine Antiviral No Down CCN intercellular signaling protein family receptor signaling 0.006925405 3 NaN CTGF;CYR61
delavirdine Antiviral No Up Cellular cholesterol uptake and efflux 0.021860273 15.5 NaN ABCA1;SCARA3
delavirdine Antiviral No Up Centrosome separation 0.000618808 1 NaN CCNB1;NEK2;SPAG5
delavirdine Antiviral No Up Chaperone-mediated autophagy 0.035495973 20.5 NaN HSPA8
delavirdine Antiviral No Up Cholesterol synthesis 0.049079429 22 NaN DHCR24;FDFT1
delavirdine Antiviral No Up Classical complement pathway 0.006315881 8 NaN C1R;C1S
delavirdine Antiviral No Up Decorin synthesis 0.017907551 13.5 NaN DCN
delavirdine Antiviral No Up Drug and toxin export via membrane transport proteins 0.003786015 7 NaN ABCA1;ABCC3;ABCC5
delavirdine Antiviral No Down Eicosanoid metabolism 0.007026965 4 NaN PLA2G4A;PTGS1;PTGS2
delavirdine Antiviral No Up Endogenous control of complement activity 0.003079589 4.5 NaN CFH;CFI
delavirdine Antiviral No Down Extracellular matrix breakdown by matrix metalloproteases 0.023206981 7 NaN BSG;MMP9
delavirdine Antiviral No Up Fibronectin synthesis and extracellular assembly 0.003079589 4.5 NaN FN1;ITGB3
delavirdine Antiviral No Down Filopodium organization 0.026137435 9 NaN ENAH;GPM6A;TNK2
delavirdine Antiviral No Down GABA metabolism 0.010202989 5 NaN ABAT;SLC6A1
delavirdine Antiviral No Down Glutamate and glutamine metabolism 0.004597545 1.5 NaN SLC1A5;SLC38A2;SLC7A5
delavirdine Antiviral No Down Glycolysis and Gluconeogenesis 0.023326766 8 NaN HK2;PFKFB3;PFKFB4
delavirdine Antiviral No Up Granulocyte-colony stimulating factor receptor signaling 0.010574722 11 NaN SOCS3;STAT3
delavirdine Antiviral No Up Growth differentiation factor receptor signaling 0.008322328 9.5 NaN GDF2;GDF6
delavirdine Antiviral No Down Hippo signaling 0.032277294 14 NaN AMOTL1;CRB2;WWC1
delavirdine Antiviral No Up Inhibin receptor signaling 0.008322328 9.5 NaN INHBE;TGFBR3
delavirdine Antiviral No Up JAK-STAT signaling pathway 0.025206934 17 NaN SOCS3;STAT3
delavirdine Antiviral No Up Leptin receptor signaling 0.001869797 2 NaN SOCS3;STAT3
delavirdine Antiviral No Up Macrophage migration inhibitory factor signaling 0.003079589 4.5 NaN ACKR3;CXCR4
delavirdine Antiviral No Up Microfibril scaffold organization 0.035495973 20.5 NaN FBN1
delavirdine Antiviral No Down Notch receptor signaling 0.01593556 6 NaN DLK1;JAG1;LFNG
delavirdine Antiviral No Up Osteopontin receptor signaling 0.017907551 13.5 NaN SPP1
delavirdine Antiviral No Down Platelet-derived growth factor receptor signaling 0.034215437 15.5 NaN PDGFRA;TNK2
delavirdine Antiviral No Up Protein polyubiquitination 0.032472681 19 NaN UBC;UCHL1
delavirdine Antiviral No Up Retinol metabolism 0.021860273 15.5 NaN ALDH1A1;STRA6
delavirdine Antiviral No Down Retinol metabolism 0.004597545 1.5 NaN ALDH1A2;DHRS3;RLBP1
delavirdine Antiviral No Up Serine and glycine metabolism 0.015780154 12 NaN PHGDH;SHMT2
delavirdine Antiviral No Down Serine and glycine metabolism 0.034215437 15.5 NaN PSAT1;SLC1A5
delavirdine Antiviral No Down Tropoelastin synthesis 0.027081863 11.5 NaN ELN
delavirdine Antiviral No Down Versican synthesis 0.027081863 11.5 NaN VCAN
delavirdine Antiviral No Up WNT-Beta-catenin signaling pathway 0.027539864 18 NaN FRZB;FZD8;SFRP2;WNT2
decitabine Other chemotherapy drug No Down Aggrecan synthesis 0.023376853 14.5 NaN ACAN
decitabine Other chemotherapy drug No Down Albumin mediated blood protein transport 0.023376853 14.5 NaN ALB
decitabine Other chemotherapy drug No Down Alternative complement pathway 0.005196305 4 NaN C1S;CFH
decitabine Other chemotherapy drug No Up Amyloid plaque organization 0.001117129 2 NaN APOE;HSPB6;VSNL1
decitabine Other chemotherapy drug No Up Antigen presentation via MHC class I molecules 0.015757014 12 NaN HLA-A;HLA-B
decitabine Other chemotherapy drug No Up Aspartate and arginine metabolism 0.015757014 12 NaN ARG2;DDAH1
decitabine Other chemotherapy drug No Down Axonal intermediate filament dynamics 0.010579453 7.5 NaN NEFH;NEFM
decitabine Other chemotherapy drug No Down Biglycan synthesis 0.023376853 14.5 NaN BGN
decitabine Other chemotherapy drug No Down Cardiomyocyte depolarization during action potential 0.023376853 14.5 NaN SCN5A
decitabine Other chemotherapy drug No Up Caveolin-mediated endocytosis 0.001151024 3 NaN CAV1;CAV2
decitabine Other chemotherapy drug No Down CD44-Mediated leukocyte rolling 0.046209242 20 NaN CD44
decitabine Other chemotherapy drug No Down Cellular cholesterol uptake and efflux 0.035834633 19 NaN ABCA1;ABCG1
decitabine Other chemotherapy drug No Down Cholesterol synthesis 2.11E-07 1 NaN DHCR24;DHCR7;HMGCR;HMGCS1;MSMO1;MVD;MVK
decitabine Other chemotherapy drug No Down Collagen fibril organization by fibril-associated bridges 0.007674569 5.5 NaN COL12A1;COL9A3
decitabine Other chemotherapy drug No Down Decorin synthesis 0.023376853 14.5 NaN DCN
decitabine Other chemotherapy drug No Up DNA replication initiation 0.012705831 9 NaN CDC6;MCM5;MCM6
decitabine Other chemotherapy drug No Down ER unfolded protein response pathway 0.013889809 9 NaN ATF4;HERPUD1
decitabine Other chemotherapy drug No Up Extracellular matrix breakdown and membrane shedding by adamalysins 0.001155785 4 NaN ADAM19;ADAMTS1;ADAMTS2;ADAMTS7
decitabine Other chemotherapy drug No Up Extracellular matrix breakdown by matrix metalloproteases 0.012770499 10 NaN MMP1;MMP14
decitabine Other chemotherapy drug No Up Fibrillar collagen core structure organization 0.000824437 1 NaN COL1A1;COL1A2;COL3A1
decitabine Other chemotherapy drug No Down Fibrillar collagen core structure organization 0.021646065 11 NaN COL11A1;COL2A1
decitabine Other chemotherapy drug No Down GABA metabolism 0.007674569 5.5 NaN ABAT;SLC6A1
decitabine Other chemotherapy drug No Up Glycolysis and Gluconeogenesis 0.01007022 8 NaN PCK2;PFKFB3;PFKFB4
decitabine Other chemotherapy drug No Up Hepatocyte growth factor receptor signaling 0.039131362 16.5 NaN HGF
decitabine Other chemotherapy drug No Up Inhibin receptor signaling 0.010062749 7 NaN INHBB;INHBE
decitabine Other chemotherapy drug No Up JAK-STAT signaling pathway 0.030256623 15 NaN SOCS2;STAT4
decitabine Other chemotherapy drug No Up Microfibril scaffold organization 0.039131362 16.5 NaN MFAP2
decitabine Other chemotherapy drug No Down Mitochondrial fission 0.030788722 18 NaN DNM1;MTFR2
decitabine Other chemotherapy drug No Up Natriuretic peptide receptor signaling 0.005533298 5 NaN NPPA;NPPB
decitabine Other chemotherapy drug No Up Neuregulin receptor signaling 0.019010322 14 NaN ERBB3;SH3TC2
decitabine Other chemotherapy drug No Down Osteonectin receptor signaling 0.003166583 3 NaN SMOC2;SPOCK1
decitabine Other chemotherapy drug No Down Progesterone receptor signaling 0.023376853 14.5 NaN PGR
decitabine Other chemotherapy drug No Up Restriction point 0.015757014 12 NaN CCND2;PFKFB3
decitabine Other chemotherapy drug No Down Thin myofilament organization 0.010579453 7.5 NaN ACTA1;TNNI3
decitabine Other chemotherapy drug No Down Thrombospondin receptor signaling 4.97E-05 2 NaN THBS1;THBS2;THBS4
decitabine Other chemotherapy drug No Up Vascular endothelial growth factor receptor signaling 0.007646107 6 NaN FLT1;KDR
decitabine Other chemotherapy drug No Down WNT-Beta-catenin signaling pathway 0.016710881 10 NaN APCDD1;DACT1;DKK2;FRZB;WNT2
daunorubicin Anthracycline Yes Down Apoptosome assembly 0.048441967 13 NaN BAG3
daunorubicin Anthracycline Yes Up Cardiomyocyte pacemaker current generation 0.027854729 10 NaN CACNA1G;KCNJ5
daunorubicin Anthracycline Yes Down CD44-Mediated leukocyte rolling 0.019663305 5.5 NaN CD44
daunorubicin Anthracycline Yes Down Cellular iron storage 0.029350768 8 NaN FTL
daunorubicin Anthracycline Yes Down Chaperone-mediated autophagy 9.68E-05 1 NaN HSP90AA1;HSPA8
daunorubicin Anthracycline Yes Up Contractile ring constriction 0.010639818 6 NaN ANLN;MYLK
daunorubicin Anthracycline Yes Down Contractile ring constriction 0.048441967 13 NaN MYH14
daunorubicin Anthracycline Yes Down Contractile ring formation 0.048441967 13 NaN MYH14
daunorubicin Anthracycline Yes Down Cytosolic protein folding 0.009880028 3 NaN HSP90AA1
daunorubicin Anthracycline Yes Down Erythropoietin receptor signaling 0.038943348 10.5 NaN GAB2
daunorubicin Anthracycline Yes Up Extracellular matrix breakdown and membrane shedding by adamalysins 0.045801684 15 NaN ADAMTS5;ADAMTS7;ADAMTS8
daunorubicin Anthracycline Yes Up Extracellular matrix breakdown by heparanases and sulfatases 0.006529396 5 NaN SULF1;SULF2
daunorubicin Anthracycline Yes Up Extracellular matrix breakdown by serine proteases 0.021363034 8.5 NaN HTRA1;ST14
daunorubicin Anthracycline Yes Up Extrinsic apoptosis pathway 0.0012102 3 NaN FAS;TNFRSF10A;TNFRSF10B
daunorubicin Anthracycline Yes Up Fibrillar collagen core structure organization 0.04281872 14 NaN COL5A1;COL5A2
daunorubicin Anthracycline Yes Down Heme degradation to bilirubin 0.029350768 8 NaN HMOX1
daunorubicin Anthracycline Yes Down Hepatocyte growth factor receptor signaling 0.019663305 5.5 NaN MET
daunorubicin Anthracycline Yes Down Hyaluronan receptor CD44 signaling 0.029350768 8 NaN CD44
daunorubicin Anthracycline Yes Up Interferon beta receptor signaling 0.021363034 8.5 NaN IFIT2;IRF3
daunorubicin Anthracycline Yes Up Mitotic spindle disassembly 0.033786168 12.5 NaN CDK1
daunorubicin Anthracycline Yes Up Muscarinic receptor signaling 0.015605081 7 NaN CHRM4;RGS5
daunorubicin Anthracycline Yes Up Notch receptor signaling 0.028469401 11 NaN DLL4;LFNG;NOTCH1
daunorubicin Anthracycline Yes Up Nucleosome assembly 0.000702025 2 NaN ASF1B;BAZ1A;HIST1H1D;HIST1H1E;HIST2H2BE
daunorubicin Anthracycline Yes Down Proteasomal regulatory particle organization 0.001967001 2 NaN PSMC4;PSMD14
daunorubicin Anthracycline Yes Down Protein polyubiquitination 0.010606382 4 NaN UBC;UCHL1
daunorubicin Anthracycline Yes Down Syndecan ectodomain shedding 0.038943348 10.5 NaN ADAMTS1
daunorubicin Anthracycline Yes Up Thick myofilament organization 0.003339324 4 NaN MYBPC3;MYH7
daunorubicin Anthracycline Yes Up Tropoelastin synthesis 0.033786168 12.5 NaN ELN
daunorubicin Anthracycline Yes Up WNT-Beta-catenin signaling pathway 5.12E-05 1 NaN APCDD1;DKK2;DKK3;FRAT1;FZD10;FZD7;FZD8;SFRP2;SFRP5;WNT1
dasatinib Kinase inhibitor No Down Albumin mediated blood protein transport 0.025317572 15 NaN ALB
dasatinib Kinase inhibitor No Up Bicarbonate transmembrane transport 0.04913699 14.5 NaN CA2;CA9
dasatinib Kinase inhibitor No Down Biglycan synthesis 0.025317572 15 NaN BGN
dasatinib Kinase inhibitor No Up Calcitonin receptor signaling 0.037401081 12.5 NaN RAMP1
dasatinib Kinase inhibitor No Up CCN intercellular signaling protein family receptor signaling 0.003416552 2 NaN CTGF;NOV
dasatinib Kinase inhibitor No Down CCN intercellular signaling protein family receptor signaling 0.006072761 5.5 NaN CYR61;WISP1
dasatinib Kinase inhibitor No Up Centrosome separation 0.014446446 5 NaN CCNB1;CDK1
dasatinib Kinase inhibitor No Up Class switch recombination 0.04913699 14.5 NaN BCL6;IRF4
dasatinib Kinase inhibitor No Down Collagen fiber crosslinking 0.006072761 5.5 NaN LOX;PXDN
dasatinib Kinase inhibitor No Up Collagen fibril organization by fibril-associated bridges 0.005061213 3.5 NaN COL12A1;COL14A1
dasatinib Kinase inhibitor No Up Decorin synthesis 0.018877911 7.5 NaN DCN
dasatinib Kinase inhibitor No Down Epithelial intermediate filament dynamics 0.016169721 11 NaN KRT19;KRT7
dasatinib Kinase inhibitor No Down Extracellular matrix breakdown by matrix metalloproteases 0.020445489 12 NaN MMP14;MMP9
dasatinib Kinase inhibitor No Down Extracellular matrix breakdown by serine proteases 0.012331868 9 NaN PRSS12;PRSS8
dasatinib Kinase inhibitor No Down Fibrillar collagen core structure organization 7.49E-05 1 NaN COL11A1;COL11A2;COL2A1;COL5A1
dasatinib Kinase inhibitor No Up G2 M transition checkpoint 0.020669774 9 NaN CCNB1;CDK1
dasatinib Kinase inhibitor No Down Gap junction organization 0.047569054 19 NaN GJA1;GJA5
dasatinib Kinase inhibitor No Down Glycolysis and Gluconeogenesis 0.00243598 3 NaN ENO1;PCK2;PFKFB3;PFKFB4
dasatinib Kinase inhibitor No Down Inhibition of apoptosis 0.035660258 18 NaN IFI6;XAF1
dasatinib Kinase inhibitor No Down Microfibril scaffold organization 0.049996342 21 NaN FBN1
dasatinib Kinase inhibitor No Up Mineralocorticoid receptor signaling 0.037401081 12.5 NaN NR3C2
dasatinib Kinase inhibitor No Up Mitotic spindle assembly 0.024127969 10 NaN DLGAP5;NUSAP1
dasatinib Kinase inhibitor No Up Mitotic spindle disassembly 0.018877911 7.5 NaN CDK1
dasatinib Kinase inhibitor No Up Natriuretic peptide receptor signaling 0.005061213 3.5 NaN NPPA;NPPB
dasatinib Kinase inhibitor No Down Non-vesicular phospholipid transport 0.012331868 9 NaN PITPNM1;PLTP
dasatinib Kinase inhibitor No Down Osteopontin receptor signaling 0.025317572 15 NaN SPP1
dasatinib Kinase inhibitor No Up Platelet-derived growth factor receptor signaling 0.017439282 6 NaN PDGFRA;TNK2
dasatinib Kinase inhibitor No Down Removal of caspase inhibition 0.049996342 21 NaN XAF1
dasatinib Kinase inhibitor No Down Restriction point 0.001688656 2 NaN CCND2;CDKN1A;PFKFB3
dasatinib Kinase inhibitor No Down Semaphorin signaling 0.010263471 7 NaN DPYSL4;PLXND1;SEMA5A;SEMA6D
dasatinib Kinase inhibitor No Up Thin myofilament organization 0.000219552 1 NaN ACTA1;LMOD3;TNNI3
dasatinib Kinase inhibitor No Down Tropoelastin synthesis 0.025317572 15 NaN ELN
dasatinib Kinase inhibitor No Down Vascular endothelial growth factor receptor signaling 0.012331868 9 NaN FLT1;KDR
dasatinib Kinase inhibitor No Down Versican receptor signaling 0.049996342 21 NaN VCAN
dasatinib Kinase inhibitor No Down Versican synthesis 0.025317572 15 NaN VCAN
dasatinib Kinase inhibitor No Down WNT-Beta-catenin signaling pathway 0.005475082 4 NaN FRZB;FZD2;SFRP1;SFRP5;WNT5A;WNT9A
dasatinib Kinase inhibitor No Up Z-disc organization 0.035773535 11 NaN MYOZ1;TCAP
dabrafenib Kinase inhibitor Yes Up Aspartate and arginine metabolism 0.002245939 4 NaN ARG2;SLC7A1;SLC7A2
dabrafenib Kinase inhibitor Yes Up Chaperone mediated protein folding in ER 0.002039177 3 NaN ERP29;HSP90B1;HSPA5;PDIA3
dabrafenib Kinase inhibitor Yes Up Chondroitin sulfate and dermatan sulfate synthesis 0.01491633 11.5 NaN CHST11;SOX9
dabrafenib Kinase inhibitor Yes Down Decorin synthesis 0.016584333 9 NaN DCN
dabrafenib Kinase inhibitor Yes Up Desaturation of fatty acids 0.01491633 11.5 11 Up by cardiotoxic TKIs FADS3;SCD
dabrafenib Kinase inhibitor Yes Down DNA replication elongation 0.002647307 2 NaN MCM4;PCNA
dabrafenib Kinase inhibitor Yes Down Epithelial intermediate filament dynamics 0.007173082 4.5 NaN KRT19;KRT7
dabrafenib Kinase inhibitor Yes Up ER unfolded protein response pathway 8.66E-07 1 NaN ATF4;DDIT3;HERPUD1;HSP90B1;HSPA5
dabrafenib Kinase inhibitor Yes Up Extracellular matrix breakdown by cathepsins 0.030243397 14 NaN CTSB;CTSZ
dabrafenib Kinase inhibitor Yes Down Fibrillar collagen core structure organization 0.011279449 7 NaN COL1A2;COL3A1
dabrafenib Kinase inhibitor Yes Down Folate cycle 0.048936686 16.5 NaN DHFR
dabrafenib Kinase inhibitor Yes Up GABA metabolism 0.010853767 8 NaN ABAT;SLC6A1
dabrafenib Kinase inhibitor Yes Up Glutamate and glutamine metabolism 0.005029519 6 NaN SLC1A5;SLC38A2;SLC7A5
dabrafenib Kinase inhibitor Yes Down Glycogen synthesis and glycogenolysis 0.02818348 12.5 NaN PPP1R3A;PYGM
dabrafenib Kinase inhibitor Yes Down Hemoglobin and myoglobin synthesis 0.048936686 16.5 NaN MB
dabrafenib Kinase inhibitor Yes Down Heparin-binding EGF-like growth factor receptor signaling 0.048936686 16.5 NaN HBEGF
dabrafenib Kinase inhibitor Yes Down HIF-1 receptor signaling pathway 0.009122437 6 20 Down by cardiotoxic TKIs CITED2;EGLN3
dabrafenib Kinase inhibitor Yes Up Microtubule crosslinking and bundling 0.010853767 8 NaN MAP1B;MAP2
dabrafenib Kinase inhibitor Yes Up Natriuretic peptide receptor signaling 0.010853767 8 NaN NPPA;NPPB
dabrafenib Kinase inhibitor Yes Down Osteopontin receptor signaling 0.016584333 9 NaN SPP1
dabrafenib Kinase inhibitor Yes Up Ras signaling pathway 0.049620602 15 NaN KSR1;SHC1
dabrafenib Kinase inhibitor Yes Down Retinol metabolism 0.001135795 1 NaN ALDH1A1;ALDH1A2;ALDH1A3
dabrafenib Kinase inhibitor Yes Up Semaphorin signaling 0.014369829 10 NaN CRMP1;PLXNA2;PLXNB3;SEMA5A
dabrafenib Kinase inhibitor Yes Up Serine and glycine metabolism 6.67E-06 2 19 Up by cardiotoxic TKIs PHGDH;PSAT1;PSPH;SHMT2;SLC1A5
dabrafenib Kinase inhibitor Yes Down Serotonin and melatonin synthesis 0.048936686 16.5 NaN SLC6A4
dabrafenib Kinase inhibitor Yes Down Thin myofilament organization 0.005438922 3 21 Down by cardiotoxic TKIs ACTA1;LMOD3
dabrafenib Kinase inhibitor Yes Up Thrombospondin receptor signaling 0.004505994 5 NaN THBS1;THBS4
dabrafenib Kinase inhibitor Yes Down Tight junction organization 0.018422427 11 NaN CLDN11;CLDN6;MPP5
dabrafenib Kinase inhibitor Yes Down Tropoelastin synthesis 0.016584333 9 NaN ELN
dabrafenib Kinase inhibitor Yes Down Vasoactive intestinal peptide receptor signaling 0.032895065 14 NaN VIPR2
dabrafenib Kinase inhibitor Yes Up Versican synthesis 0.027964008 13 NaN VCAN
dabrafenib Kinase inhibitor Yes Down Water transmembrane transport 0.007173082 4.5 9 Down by cardiotoxic TKIs AQP3;AQP7
dabrafenib Kinase inhibitor Yes Down Z-disc organization 0.02818348 12.5 NaN CSRP3;TCAP
cyclosporine Immunosuppressant Yes Down Albumin mediated blood protein transport 0.02293578 13.5 NaN ALB
cyclosporine Immunosuppressant Yes Down Biglycan synthesis 0.02293578 13.5 NaN BGN
cyclosporine Immunosuppressant Yes Up CCN intercellular signaling protein family receptor signaling 0.004599768 2.5 NaN CTGF;CYR61
cyclosporine Immunosuppressant Yes Down CD44-Mediated leukocyte rolling 0.045347487 21.5 NaN CD44
cyclosporine Immunosuppressant Yes Down Cellular iron uptake and export 0.034603897 18 NaN RASD1;TFRC
cyclosporine Immunosuppressant Yes Down Decorin synthesis 0.02293578 13.5 NaN DCN
cyclosporine Immunosuppressant Yes Down Discoidin domain receptor signaling 0.00154836 2 NaN DDR2;RUNX2
cyclosporine Immunosuppressant Yes Down Endogenous control of complement activity 0.00500617 6 NaN CFH;CFI
cyclosporine Immunosuppressant Yes Down Extracellular matrix breakdown and membrane shedding by adamalysins 0.01691013 8 NaN ADAMTS14;ADAMTS2;ADAMTS8
cyclosporine Immunosuppressant Yes Down Extracellular matrix breakdown by heparanases and sulfatases 0.003049812 4.5 NaN SULF1;SULF2
cyclosporine Immunosuppressant Yes Down Extracellular matrix breakdown by matrix metalloproteases 0.01696168 9 NaN MMP1;MMP12
cyclosporine Immunosuppressant Yes Down Fibrillar collagen core structure organization 0.02088458 10 NaN COL1A2;COL2A1
cyclosporine Immunosuppressant Yes Up Fibroblast growth factor receptor signaling 0.027432825 9 NaN FGF1;FGF18
cyclosporine Immunosuppressant Yes Up Fibronectin synthesis and extracellular assembly 0.004599768 2.5 NaN FN1;ITGB3
cyclosporine Immunosuppressant Yes Up Fibulin receptor signaling 0.043450255 13 NaN FBLN1
cyclosporine Immunosuppressant Yes Down Glutamate and glutamine metabolism 0.000164225 1 NaN GLUL;SLC1A1;SLC1A5;SLC7A5
cyclosporine Immunosuppressant Yes Up Growth differentiation factor receptor signaling 0.012330009 5 NaN GDF15;GDF2
cyclosporine Immunosuppressant Yes Down Hepatocyte growth factor receptor signaling 0.045347487 21.5 NaN HGF
cyclosporine Immunosuppressant Yes Up JAK-STAT signaling pathway 0.036753502 10 NaN SOCS3;STAT4
cyclosporine Immunosuppressant Yes Down Mitotic spindle disassembly 0.02293578 13.5 NaN CDK1
cyclosporine Immunosuppressant Yes Down Natriuretic peptide receptor signaling 0.007395936 7 NaN NPPA;NPPB
cyclosporine Immunosuppressant Yes Up Notch receptor signaling 0.009053903 4 NaN DLK1;JAG1;NOTCH3
cyclosporine Immunosuppressant Yes Down Osteonectin receptor signaling 0.003049812 4.5 NaN SMOC2;SPARC
cyclosporine Immunosuppressant Yes Down Osteopontin receptor signaling 0.02293578 13.5 NaN SPP1
cyclosporine Immunosuppressant Yes Up Platelet-derived growth factor receptor signaling 0.023192176 8 NaN PDGFB;TNK2
cyclosporine Immunosuppressant Yes Up Progesterone receptor signaling 0.02196542 7 NaN PGR
cyclosporine Immunosuppressant Yes Down Prostaglandin PGF2 alpha receptor signaling 0.045347487 21.5 NaN PTGFR
cyclosporine Immunosuppressant Yes Down Retinol metabolism 0.002876507 3 NaN ALDH1A1;ALDH1A2;STRA6
cyclosporine Immunosuppressant Yes Down rRNA transcription 0.045209403 19 NaN BNC1;BNC2
cyclosporine Immunosuppressant Yes Up Semaphorin signaling 0.037991607 11 NaN PLXNA2;PLXNA4;SEMA6B
cyclosporine Immunosuppressant Yes Down Serine and glycine metabolism 0.025144066 17 NaN SHMT2;SLC1A5
cyclosporine Immunosuppressant Yes Up Serotonin inactivation 0.043450255 13 NaN MAOB
cyclosporine Immunosuppressant Yes Down Serotonin inactivation 0.045347487 21.5 NaN MAOA
cyclosporine Immunosuppressant Yes Up Thrombospondin receptor signaling 0.002800402 1 NaN THBS1;THBS4
cyclosporine Immunosuppressant Yes Down Tropoelastin synthesis 0.02293578 13.5 NaN ELN
cyclosporine Immunosuppressant Yes Up Vasoactive intestinal peptide receptor signaling 0.043450255 13 NaN VIPR1
cyclosporine Immunosuppressant Yes Up WNT-Beta-catenin signaling pathway 0.013073502 6 NaN APCDD1;DACT1;SFRP4;SFRP5;WNT1
crizotinib Kinase inhibitor No Down Adherens junction organization 0.031245885 17 NaN ALCAM;CDH3;CTNND2;TIAM1
crizotinib Kinase inhibitor No Down Aggrecan synthesis 0.029287227 15 NaN ACAN
crizotinib Kinase inhibitor No Up Albumin mediated blood protein transport 0.013849682 7 NaN ALB
crizotinib Kinase inhibitor No Down Basement membrane assembly and organization 0.002563095 4 NaN COL4A1;COL4A4;COL8A2
crizotinib Kinase inhibitor No Up Biglycan synthesis 0.013849682 7 NaN BGN
crizotinib Kinase inhibitor No Down Cardiomyocyte pacemaker current generation 0.021304837 12.5 NaN CACNA1G;HCN4
crizotinib Kinase inhibitor No Up CD44-Mediated leukocyte rolling 0.027508756 11 NaN CD44
crizotinib Kinase inhibitor No Down Cellular cholesterol uptake and efflux 0.005722729 6 NaN ABCA1;ABCA7;ABCG1
crizotinib Kinase inhibitor No Up Cellular iron storage 0.040979828 17.5 NaN FTH1
crizotinib Kinase inhibitor No Up Coagulation cascade 0.011484345 5 NaN F3;TFPI
crizotinib Kinase inhibitor No Down Collagen fiber crosslinking 0.008065076 7.5 NaN LOX;LOXL1
crizotinib Kinase inhibitor No Down Collagen fibril organization by fibril-associated bridges 0.011864496 9 NaN COL12A1;COL9A1
crizotinib Kinase inhibitor No Down Contractile ring constriction 0.008065076 7.5 NaN ANLN;MYH14
crizotinib Kinase inhibitor No Up Decorin synthesis 0.013849682 7 NaN DCN
crizotinib Kinase inhibitor No Up Discoidin domain receptor signaling 0.040979828 17.5 NaN DDR2
crizotinib Kinase inhibitor No Down Elastin cross-linking and assembly 0.002515899 3 NaN LOX;LOXL1
crizotinib Kinase inhibitor No Up Endogenous control of complement activity 0.001854483 3 NaN CFH;CFI
crizotinib Kinase inhibitor No Up Extracellular matrix breakdown and membrane shedding by adamalysins 0.043108095 22 NaN ADAMTS2;ADAMTS5
crizotinib Kinase inhibitor No Down Extracellular matrix breakdown and membrane shedding by adamalysins 0.000561546 2 NaN ADAMTS1;ADAMTS12;ADAMTS14;ADAMTS6;ADAMTS7
crizotinib Kinase inhibitor No Up Extracellular matrix breakdown by heparanases and sulfatases 0.001122905 2 NaN SULF1;SULF2
crizotinib Kinase inhibitor No Down Extracellular matrix breakdown by serine proteases 0.016291005 10 NaN PRSS12;PRSS8
crizotinib Kinase inhibitor No Up Fatty acid transfer between membranes 0.040979828 17.5 NaN FABP3
crizotinib Kinase inhibitor No Down Fibrillar collagen core structure organization 0.000131941 1 NaN COL11A1;COL1A1;COL2A1;COL5A1
crizotinib Kinase inhibitor No Up Fibrillin synthesis 0.040979828 17.5 NaN FBN1
crizotinib Kinase inhibitor No Down G-protein coupled receptor signaling pathway 0.019611275 11 NaN PDE4D;RGS5;RGS6
crizotinib Kinase inhibitor No Down Growth differentiation factor receptor signaling 0.021304837 12.5 NaN GDF15;GDF6
crizotinib Kinase inhibitor No Up Heparin-binding EGF-like growth factor receptor signaling 0.040979828 17.5 NaN HBEGF
crizotinib Kinase inhibitor No Up Hepatocyte growth factor receptor signaling 0.027508756 11 NaN HGF
crizotinib Kinase inhibitor No Up Hyaluronan receptor CD44 signaling 0.040979828 17.5 NaN CD44
crizotinib Kinase inhibitor No Up Inhibition of amyloid aggregation, amyloid degradation and uptake 0.040979828 17.5 NaN A2M
crizotinib Kinase inhibitor No Up Methionine cycle 0.027508756 11 NaN BHMT
crizotinib Kinase inhibitor No Up Microfibril scaffold organization 0.027508756 11 NaN FBN1
crizotinib Kinase inhibitor No Up Natriuretic peptide receptor signaling 0.002756446 4 NaN NPPA;NPPB
crizotinib Kinase inhibitor No Down Platelet-derived growth factor receptor signaling 0.003448295 5 NaN PDGFB;RGS5;TNK2
crizotinib Kinase inhibitor No Up Removal of caspase inhibition 0.027508756 11 NaN XAF1
crizotinib Kinase inhibitor No Up Retinol metabolism 0.000673123 1 NaN ALDH1A1;ALDH1A2;DHRS3
crizotinib Kinase inhibitor No Up Thick myofilament organization 0.040979828 17.5 NaN MYH7
crizotinib Kinase inhibitor No Down Tropoelastin synthesis 0.029287227 15 NaN ELN
crizotinib Kinase inhibitor No Down Versican synthesis 0.029287227 15 NaN VCAN
crizotinib Kinase inhibitor No Down WNT-Beta-catenin signaling pathway 0.039082025 18 NaN AMER1;FRZB;PAX6;SFRP2;WNT9A
cetuximab Monoclonal antibody No Up Albumin mediated blood protein transport 0.025935074 12.5 NaN ALB
cetuximab Monoclonal antibody No Up Alternative complement pathway 0.006365168 4.5 NaN C3;CFH
cetuximab Monoclonal antibody No Up Axonal intermediate filament dynamics 0.012914996 7.5 NaN NEFH;NES
cetuximab Monoclonal antibody No Down Centrosome maturation 0.02346865 14.5 NaN PLK1;TPX2
cetuximab Monoclonal antibody No Down Centrosome separation 7.47E-07 1 NaN CCNB1;CDK1;KIF11;NEK2;SPAG5
cetuximab Monoclonal antibody No Down Cholesterol synthesis 1.95E-06 2 NaN DHCR24;DHCR7;HMGCR;HMGCS1;MSMO1;MVD
cetuximab Monoclonal antibody No Down Contractile ring constriction 0.003903051 8 NaN ANLN;ECT2
cetuximab Monoclonal antibody No Up Decorin synthesis 0.025935074 12.5 NaN DCN
cetuximab Monoclonal antibody No Down Eukaryotic kinetochore dynamics 0.000938379 5 NaN BUB1;CENPE;CENPF;NDC80;TTK
cetuximab Monoclonal antibody No Up Fibrillar collagen core structure organization 8.23E-05 1 NaN COL1A1;COL1A2;COL3A1;COL5A1
cetuximab Monoclonal antibody No Down G2 M transition checkpoint 0.02346865 14.5 NaN CCNB1;CDK1
cetuximab Monoclonal antibody No Down GABA metabolism 0.005776787 9 NaN ABAT;SLC6A1
cetuximab Monoclonal antibody No Up Granulocyte macrophage colony-stimulating factor receptor signaling 0.000670399 2 NaN JAK2;JUND
cetuximab Monoclonal antibody No Down Hepatocyte growth factor receptor signaling 0.039995919 18.5 NaN HGF
cetuximab Monoclonal antibody No Up HIF-1 receptor signaling pathway 0.021394782 10 NaN CITED2;EGLN3
cetuximab Monoclonal antibody No Down Hyaluronan-mediated motility receptor signaling 0.020201129 11.5 NaN HMMR
cetuximab Monoclonal antibody No Down Inhibition of amyloid aggregation, amyloid degradation and uptake 8.14E-06 3 NaN A2M;MME;PLAT
cetuximab Monoclonal antibody No Down Inhibition of apoptosis 0.001564153 7 NaN BIRC5;IFI6;XAF1
cetuximab Monoclonal antibody No Up Macrophage migration inhibitory factor signaling 0.006365168 4.5 NaN ACKR3;JUND
cetuximab Monoclonal antibody No Down Metaphase to anaphase checkpoint 0.030735645 16 NaN BUB1;CENPE;TTK
cetuximab Monoclonal antibody No Down Mitotic spindle assembly 0.000100501 4 NaN DLGAP5;NUSAP1;TPX2;TTK
cetuximab Monoclonal antibody No Down Mitotic spindle disassembly 0.020201129 11.5 NaN CDK1
cetuximab Monoclonal antibody No Up Myofibril formation 0.001809764 3 NaN DES;KLHL41;XIRP1
cetuximab Monoclonal antibody No Up Neuregulin receptor signaling 0.031591061 15 NaN ERBB2;ERBB3
cetuximab Monoclonal antibody No Down Osteopontin receptor signaling 0.020201129 11.5 NaN SPP1
cetuximab Monoclonal antibody No Up Progesterone receptor signaling 0.025935074 12.5 NaN PGR
cetuximab Monoclonal antibody No Down Prostaglandin PGF2 alpha receptor signaling 0.039995919 18.5 NaN PTGFR
cetuximab Monoclonal antibody No Down Removal of caspase inhibition 0.039995919 18.5 NaN XAF1
cetuximab Monoclonal antibody No Down Serine and glycine metabolism 0.001190789 6 NaN PHGDH;PSAT1;SHMT2
cetuximab Monoclonal antibody No Up Thin myofilament organization 0.012914996 7.5 NaN ACTA1;LMOD3
cetuximab Monoclonal antibody No Up Tropoelastin synthesis 0.025935074 12.5 NaN ELN
cetuximab Monoclonal antibody No Down Versican receptor signaling 0.039995919 18.5 NaN VCAN
cetuximab Monoclonal antibody No Down Versican synthesis 0.020201129 11.5 NaN VCAN
cetuximab Monoclonal antibody No Up Water transmembrane transport 0.01692739 9 NaN AQP3;AQP7
cetuximab Monoclonal antibody No Up Z-disc organization 0.007526147 6 NaN CSRP3;DES;PDLIM3
ceritinib Kinase inhibitor No Up Actin filament bundling and crosslinking 0.000886033 5 NaN FLNA;FLNB;FSCN2;PLS3;SYNPO
ceritinib Kinase inhibitor No Up Aggrecan synthesis 0.029728299 22 NaN ACAN
ceritinib Kinase inhibitor No Up Amyloid plaque organization 0.040591897 27 NaN APBB2;APOE
ceritinib Kinase inhibitor No Up Antigen presentation via MHC class I molecules 0.033865605 26 NaN HLA-B;HLA-C
ceritinib Kinase inhibitor No Down Base excision repair 0.001281927 15 NaN FEN1;NEIL3;PCNA;POLQ
ceritinib Kinase inhibitor No Up Biglycan synthesis 0.029728299 22 NaN BGN
ceritinib Kinase inhibitor No Up CCN intercellular signaling protein family receptor signaling 0.008302765 12.5 NaN CYR61;WISP1
ceritinib Kinase inhibitor No Down Centrosome maturation 0.000998085 13.5 NaN AURKA;PLK1;TPX2
ceritinib Kinase inhibitor No Down Centrosome organization 0.00634391 19 NaN ASPM;NEK2;POC1A;TACC3;WDR62
ceritinib Kinase inhibitor No Down Centrosome separation 4.77E-11 2 NaN AURKA;CCNB1;CDK1;ESPL1;KIF11;NEK2;SPAG5
ceritinib Kinase inhibitor No Up Cholesterol-sensitive control of SREBP activation 0.012210551 14 NaN INSIG1;SREBF1
ceritinib Kinase inhibitor No Up Classical complement pathway 0.000833823 3 NaN C1QB;C1QC;C1R
ceritinib Kinase inhibitor No Up Coagulation cascade 0.047771954 28.5 NaN F2RL1;TFPI
ceritinib Kinase inhibitor No Up Collagen fiber crosslinking 0.008302765 12.5 NaN LOX;PXDN
ceritinib Kinase inhibitor No Down Contractile ring constriction 0.002873937 17.5 NaN ANLN;ECT2
ceritinib Kinase inhibitor No Up Decorin synthesis 0.029728299 22 NaN DCN
ceritinib Kinase inhibitor No Down DNA cleavage 0.014762628 22 NaN FEN1;HMGB2
ceritinib Kinase inhibitor No Down DNA replication elongation 0.002873937 17.5 NaN MCM4;PCNA
ceritinib Kinase inhibitor No Down DNA replication initiation 3.33E-06 6 NaN CDC45;CDC6;GINS1;GINS2;MCM10;MCM4
ceritinib Kinase inhibitor No Up Epidermal growth factor receptor signaling 0.029688885 19 NaN ERRFI1;SH3PXD2B;TNK2
ceritinib Kinase inhibitor No Down Equatorial RhoA activation 0.001744211 16 NaN ECT2;KIF23
ceritinib Kinase inhibitor No Down Eukaryotic kinetochore dynamics 3.07E-14 1 NaN BUB1;CENPE;CENPF;CENPH;CENPU;KIF15;MAD2L1;NDC80;NUF2;SKA3;SPC24;TTK;ZWINT
ceritinib Kinase inhibitor No Up Extracellular matrix breakdown and membrane shedding by adamalysins 0.005090993 10 NaN ADAM12;ADAM33;ADAMTS10;ADAMTS2
ceritinib Kinase inhibitor No Up Extracellular matrix breakdown by heparanases and sulfatases 0.005081293 8 NaN SULF1;SULF2
ceritinib Kinase inhibitor No Up Extracellular matrix breakdown by matrix metalloproteases 0.027627429 18 NaN MMP14;MMP2
ceritinib Kinase inhibitor No Down Fanconi anemia interstrand cross-link repair pathway 7.19E-05 8 NaN BRCA2;BRIP1;FANCD2;FANCI;UBE2T
ceritinib Kinase inhibitor No Up Fibrillar collagen core structure organization 2.14E-09 1 NaN COL11A1;COL1A1;COL1A2;COL3A1;COL5A1;COL5A2;COL5A3
ceritinib Kinase inhibitor No Up Filopodium organization 0.033202869 25 NaN DAAM2;FMNL2;TNK2
ceritinib Kinase inhibitor No Down G2 M transition checkpoint 0.000998085 13.5 NaN CCNB1;CDC25C;CDK1
ceritinib Kinase inhibitor No Down Glycolysis and Gluconeogenesis 0.006986429 20 NaN LDHA;PGK1;TPI1
ceritinib Kinase inhibitor No Down Homologous recombination DSB repair 0.044900726 25 NaN BRCA2;EXO1;RAD51AP1
ceritinib Kinase inhibitor No Down Hyaluronan-mediated motility receptor signaling 0.017290049 23.5 NaN HMMR
ceritinib Kinase inhibitor No Up Inhibition of amyloid aggregation, amyloid degradation and uptake 2.60E-05 2 NaN A2M;MME;PLAT
ceritinib Kinase inhibitor No Up Inhibition of apoptosis 0.047771954 28.5 NaN IFI6;XAF1
ceritinib Kinase inhibitor No Up Interferon alpha receptor signaling 0.02191339 17 NaN IRF9;STAT1
ceritinib Kinase inhibitor No Down Intracellular bridge assembly 0.000882158 11.5 NaN INCENP;KIF23
ceritinib Kinase inhibitor No Down Metaphase to anaphase checkpoint 8.55E-08 4 NaN BUB1;BUB1B;CCNB2;CDC20;CENPE;MAD2L1;PTTG1;TTK
ceritinib Kinase inhibitor No Up Microfibril scaffold organization 0.000881227 4 NaN FBN1;MFAP2
ceritinib Kinase inhibitor No Down Mitotic chromosome condensation 2.91E-06 5 NaN INCENP;NCAPG2;SMC2;SMC4
ceritinib Kinase inhibitor No Down Mitotic H3 phosphorylation and dephosphorylation 4.96E-05 7 NaN AURKB;CCNA2;INCENP
ceritinib Kinase inhibitor No Down Mitotic spindle assembly 3.84E-08 3 NaN CKAP2;DLGAP5;NUSAP1;TACC3;TPX2;TTK
ceritinib Kinase inhibitor No Down Mitotic spindle disassembly 0.017290049 23.5 NaN CDK1
ceritinib Kinase inhibitor No Up NOD-like receptor signaling 0.005966066 11 NaN NLRC5;NLRP1;NOD1
ceritinib Kinase inhibitor No Up Non-vesicular phospholipid transport 0.016761242 15.5 NaN PITPNM1;PLTP
ceritinib Kinase inhibitor No Up Osteonectin receptor signaling 0.005081293 8 NaN SMOC2;SPARC
ceritinib Kinase inhibitor No Up Osteopontin receptor signaling 0.029728299 22 NaN SPP1
ceritinib Kinase inhibitor No Up Platelet-derived growth factor receptor signaling 0.00359729 6 NaN PDGFRA;PDGFRB;TNK2
ceritinib Kinase inhibitor No Down Pyrimidine synthesis and salvage 0.007776169 21 NaN TK1;TYMS
ceritinib Kinase inhibitor No Down Ribonucleotide reduction 0.000882158 11.5 NaN RRM1;RRM2
ceritinib Kinase inhibitor No Down Sister chromatid attachment to mitotic spindle 0.000297447 10 NaN NUF2;TACC3
ceritinib Kinase inhibitor No Down Sister chromatid segregation 9.80E-05 9 NaN ESPL1;PTTG1;TOP2A
ceritinib Kinase inhibitor No Up Thin myofilament organization 0.016761242 15.5 NaN ACTA1;TPM4
ceritinib Kinase inhibitor No Up Thrombospondin receptor signaling 0.005081293 8 NaN THBS1;THBS2
ceritinib Kinase inhibitor No Up Tropoelastin synthesis 0.029728299 22 NaN ELN
carfilzomib Antiproteasome Yes Down Basement membrane assembly and organization 0.041001024 16 NaN COL4A5;HSPG2
carfilzomib Antiproteasome Yes Down Biglycan synthesis 0.032992237 12.5 NaN BGN
carfilzomib Antiproteasome Yes Up CD44-Mediated leukocyte rolling 0.020711186 5.5 NaN CD44
carfilzomib Antiproteasome Yes Up Cellular iron storage 0.030906711 10 NaN FTL
carfilzomib Antiproteasome Yes Up Chaperone-mediated autophagy 0.020711186 5.5 NaN HSPA8
carfilzomib Antiproteasome Yes Down Decorin synthesis 0.032992237 12.5 NaN DCN
carfilzomib Antiproteasome Yes Up Epidermal growth factor receptor signaling 0.023570453 8 NaN ERRFI1;SPINK1
carfilzomib Antiproteasome Yes Down Epithelial intermediate filament dynamics 0.026644498 9 NaN KRT8;TCHH
carfilzomib Antiproteasome Yes Up ER unfolded protein response pathway 0.002887618 1 NaN DDIT3;PPP1R15A
carfilzomib Antiproteasome Yes Up Erythropoietin receptor signaling 0.040996979 12 NaN GAB2
carfilzomib Antiproteasome Yes Down Extracellular matrix breakdown by heparanases and sulfatases 0.00623247 5 NaN SULF1;SULF2
carfilzomib Antiproteasome Yes Up Extracellular matrix breakdown by matrix metalloproteases 0.00368744 2 NaN MMP1;MMP3
carfilzomib Antiproteasome Yes Down Extracellular matrix breakdown by serine proteases 0.020424115 7.5 NaN HTRA1;ST14
carfilzomib Antiproteasome Yes Down Extrinsic apoptosis pathway 0.001129403 3 NaN FAS;TNFRSF10A;TNFRSF10B
carfilzomib Antiproteasome Yes Down Fibrillar collagen core structure organization 8.37E-06 1 NaN COL1A1;COL1A2;COL3A1;COL5A1;COL5A2
carfilzomib Antiproteasome Yes Up Heme degradation to bilirubin 0.030906711 10 NaN HMOX1
carfilzomib Antiproteasome Yes Up Hepatocyte growth factor receptor signaling 0.020711186 5.5 NaN MET
carfilzomib Antiproteasome Yes Up Hyaluronan receptor CD44 signaling 0.030906711 10 NaN CD44
carfilzomib Antiproteasome Yes Up Mineralocorticoid receptor signaling 0.020711186 5.5 NaN GPER1
carfilzomib Antiproteasome Yes Down Muscarinic receptor signaling 0.01491134 6 NaN CHRM4;RGS5
carfilzomib Antiproteasome Yes Down Notch receptor signaling 0.026772904 10 NaN DLK1;DLL4;LFNG
carfilzomib Antiproteasome Yes Up Nuclear mRNA export 0.013193945 3 NaN NXF1;THOC6
carfilzomib Antiproteasome Yes Down Nucleosome assembly 0.000630086 2 NaN ASF1B;HIST1H1C;HIST1H1D;HIST1H1E;HIST2H2BE
carfilzomib Antiproteasome Yes Down Nucleotide excision repair 0.038691864 15 NaN DDB2;PCNA;XPC
carfilzomib Antiproteasome Yes Down Perlecan synthesis 0.032992237 12.5 NaN HSPG2
carfilzomib Antiproteasome Yes Down Ribonucleotide reduction 0.003185752 4 NaN RRM2;RRM2B
carfilzomib Antiproteasome Yes Down Thin myofilament organization 0.020424115 7.5 NaN NEBL;TPM1
carfilzomib Antiproteasome Yes Down Tropoelastin synthesis 0.032992237 12.5 NaN ELN
cabozantinib Kinase inhibitor No Down Aggrecan synthesis 0.022053634 15 NaN ACAN
cabozantinib Kinase inhibitor No Up Albumin mediated blood protein transport 0.022318278 11 NaN ALB
cabozantinib Kinase inhibitor No Down Alternative complement pathway 0.004636036 8.5 NaN C3;CFH
cabozantinib Kinase inhibitor No Down Basement membrane assembly and organization 0.019397192 12 NaN COL4A1;HSPG2
cabozantinib Kinase inhibitor No Up Betaglycan signaling 0.004745654 4 NaN SMAD6;TGFBR3
cabozantinib Kinase inhibitor No Down Biglycan synthesis 0.022053634 15 NaN BGN
cabozantinib Kinase inhibitor No Down Cardiomyocyte depolarization during action potential 0.022053634 15 NaN SCN5A
cabozantinib Kinase inhibitor No Down Cardiomyocyte pacemaker current generation 0.012425035 11 NaN CACNA1G;HCN4
cabozantinib Kinase inhibitor No Down CCN intercellular signaling protein family receptor signaling 0.004636036 8.5 NaN CTGF;CYR61
cabozantinib Kinase inhibitor No Down Cellular iron uptake and export 0.032195057 19 NaN RASD1;TFRC
cabozantinib Kinase inhibitor No Up Centrosome separation 0.019838394 8 NaN CCNB1;CDK1
cabozantinib Kinase inhibitor No Down Chaperone-mediated autophagy 0.043622809 26 NaN HSPA8
cabozantinib Kinase inhibitor No Down Chloride transmembrane transport 0.032195057 19 NaN ANO1;SLC12A7
cabozantinib Kinase inhibitor No Up Cholesterol synthesis 3.47E-06 1 NaN CYP51A1;HMGCR;HMGCS1;MSMO1;MVK;SQLE
cabozantinib Kinase inhibitor No Up Chondroitin sulfate and dermatan sulfate synthesis 0.009675618 7 NaN CHST11;SOX9
cabozantinib Kinase inhibitor No Down Collagen fiber crosslinking 0.00010257 4 NaN LOX;LOXL1;PXDN
cabozantinib Kinase inhibitor No Up Collagen fibril organization by fibril-associated bridges 0.007013957 5.5 NaN COL14A1;COL9A2
cabozantinib Kinase inhibitor No Down Decorin synthesis 0.022053634 15 NaN DCN
cabozantinib Kinase inhibitor No Down Eicosanoid metabolism 0.042110321 22 NaN CYP2J2;PTGS1
cabozantinib Kinase inhibitor No Down Elastin cross-linking and assembly 0.001432179 6 NaN LOX;LOXL1
cabozantinib Kinase inhibitor No Down Extracellular matrix breakdown and membrane shedding by adamalysins 0.001733291 7 NaN ADAM12;ADAMTS14;ADAMTS2;ADAMTS9
cabozantinib Kinase inhibitor No Down Extracellular matrix breakdown by matrix metalloproteases 0.000806813 5 NaN MMP1;MMP14;MMP2
cabozantinib Kinase inhibitor No Down Fibrillar collagen core structure organization 2.11E-08 1 NaN COL1A1;COL1A2;COL2A1;COL3A1;COL5A1;COL5A3
cabozantinib Kinase inhibitor No Up G2 M transition checkpoint 0.028256676 15 NaN CCNB1;CDK1
cabozantinib Kinase inhibitor No Down Gap junction organization 0.037023918 21 NaN GJA1;GJA5
cabozantinib Kinase inhibitor No Down Glycolysis and Gluconeogenesis 7.98E-06 2 NaN ALDOA;ENO1;LDHA;PFKL;PGK1;TPI1
cabozantinib Kinase inhibitor No Down Hepatocyte growth factor receptor signaling 0.043622809 26 NaN HGF
cabozantinib Kinase inhibitor No Down Inhibition of amyloid aggregation, amyloid degradation and uptake 1.06E-05 3 NaN A2M;MME;PLAT
cabozantinib Kinase inhibitor No Down Methionine cycle 0.043622809 26 NaN BHMT
cabozantinib Kinase inhibitor No Down Microfibril scaffold organization 0.043622809 26 NaN FBN1
cabozantinib Kinase inhibitor No Up Microtubule crosslinking and bundling 0.007013957 5.5 NaN MAP2;MTCL1
cabozantinib Kinase inhibitor No Up Mitotic spindle disassembly 0.022318278 11 NaN CDK1
cabozantinib Kinase inhibitor No Up Osteonectin receptor signaling 0.002889904 2.5 NaN SMOC1;SPOCK1
cabozantinib Kinase inhibitor No Up Osteopontin receptor signaling 0.022318278 11 NaN SPP1
cabozantinib Kinase inhibitor No Down Perlecan synthesis 0.022053634 15 NaN HSPG2
cabozantinib Kinase inhibitor No Up Platelet-derived growth factor receptor signaling 0.023894185 14 NaN PDGFD;TNK2
cabozantinib Kinase inhibitor No Down Removal of caspase inhibition 0.043622809 26 NaN XAF1
cabozantinib Kinase inhibitor No Up Retinol metabolism 0.032910271 16 NaN ALDH1A1;RDH10
cabozantinib Kinase inhibitor No Down Retinol metabolism 0.032195057 19 NaN ALDH1A2;DHRS3
cabozantinib Kinase inhibitor No Down Serotonin inactivation 0.043622809 26 NaN MAOA
cabozantinib Kinase inhibitor No Up Thrombospondin receptor signaling 0.002889904 2.5 NaN CD47;THBS4
cabozantinib Kinase inhibitor No Up Tropoelastin synthesis 0.022318278 11 NaN ELN
cabozantinib Kinase inhibitor No Down Vascular endothelial growth factor receptor signaling 0.009455468 10 NaN FLT1;VEGFA
cabozantinib Kinase inhibitor No Down Vasoactive intestinal peptide receptor signaling 0.043622809 26 NaN VIPR2
cabozantinib Kinase inhibitor No Up Versican receptor signaling 0.044140376 17 NaN VCAN
cabozantinib Kinase inhibitor No Up Versican synthesis 0.022318278 11 NaN VCAN
bosutinib Kinase inhibitor No Up Actin filament bundling and crosslinking 0.016825429 7 NaN SYNPO;TAGLN;USH1C
bosutinib Kinase inhibitor No Up Aggrecan synthesis 0.021083275 10 NaN ACAN
bosutinib Kinase inhibitor No Up Albumin mediated blood protein transport 0.021083275 10 NaN ALB
bosutinib Kinase inhibitor No Down Alternative complement pathway 0.004636036 6 NaN C3;CFH
bosutinib Kinase inhibitor No Down CD44-Mediated leukocyte rolling 0.043622809 17.5 NaN CD44
bosutinib Kinase inhibitor No Down Cholesterol synthesis 0.009153583 9 NaN DHCR7;MVD;SQLE
bosutinib Kinase inhibitor No Up Collagen fibril organization by fibril-associated bridges 0.006278564 5 NaN COL9A2;COL9A3
bosutinib Kinase inhibitor No Down Collagen fibril organization by fibril-associated bridges 0.006853158 7.5 NaN COL12A1;COL9A1
bosutinib Kinase inhibitor No Down Decorin synthesis 0.022053634 11 NaN DCN
bosutinib Kinase inhibitor No Up Epithelial intermediate filament dynamics 0.011397983 6 NaN KRT7;KRT8
bosutinib Kinase inhibitor No Up Fibrillar collagen core structure organization 0.000995243 3 NaN COL11A1;COL11A2;COL2A1
bosutinib Kinase inhibitor No Down Fibrillar collagen core structure organization 0.001133868 3 NaN COL1A1;COL1A2;COL3A1
bosutinib Kinase inhibitor No Down GABA metabolism 0.006853158 7.5 NaN ABAT;SLC6A1
bosutinib Kinase inhibitor No Down Granulocyte macrophage colony-stimulating factor receptor signaling 0.043622809 17.5 NaN JAK2
bosutinib Kinase inhibitor No Up Hepatocyte growth factor receptor signaling 0.041723865 13.5 NaN MET
bosutinib Kinase inhibitor No Down Hepatocyte growth factor receptor signaling 0.043622809 17.5 NaN HGF
bosutinib Kinase inhibitor No Down Inhibin receptor signaling 0.000546766 2 NaN INHA;INHBB;TGFBR3
bosutinib Kinase inhibitor No Down Inhibition of amyloid aggregation, amyloid degradation and uptake 0.001432179 4 NaN MME;PLAT
bosutinib Kinase inhibitor No Down JAK-STAT signaling pathway 0.037023918 13 NaN SOCS2;SOCS3
bosutinib Kinase inhibitor No Up Lipid droplet fusion 0.021083275 10 NaN CIDEC
bosutinib Kinase inhibitor No Down Lipogenesis 0.043622809 17.5 NaN FASN
bosutinib Kinase inhibitor No Up Microfibril scaffold organization 0.041723865 13.5 NaN FBN1
bosutinib Kinase inhibitor No Up Natriuretic peptide receptor signaling 2.80E-06 1 NaN NPPA;NPPB;NPPC;NPR3
bosutinib Kinase inhibitor No Up Osteopontin receptor signaling 0.021083275 10 NaN SPP1
bosutinib Kinase inhibitor No Up Potassium transmembrane transport 0.00146888 4 NaN ATP1A2;ATP1A3;KCNE4;SLC12A1
bosutinib Kinase inhibitor No Down Retinol metabolism 0.032195057 12 NaN CYP26A1;RDH10
bosutinib Kinase inhibitor No Down Roundabout signaling 0.009455468 10 NaN ROBO1;ROBO2
bosutinib Kinase inhibitor No Down Semaphorin signaling 0.038375695 14 NaN DPYSL4;SEMA5A;SEMA6D
bosutinib Kinase inhibitor No Down Serotonin inactivation 0.043622809 17.5 NaN MAOA
bosutinib Kinase inhibitor No Up Thin myofilament organization 6.42E-06 2 NaN ACTA1;TNNI3;TPM2;TPM4
bosutinib Kinase inhibitor No Down Thrombospondin receptor signaling 0.00282265 5 NaN THBS1;THBS4
bosutinib Kinase inhibitor No Up Tropoelastin synthesis 0.021083275 10 NaN ELN
bosutinib Kinase inhibitor No Down Vasoactive intestinal peptide receptor signaling 0.043622809 17.5 NaN VIPR1
bosutinib Kinase inhibitor No Down WNT-Beta-catenin signaling pathway 7.62E-05 1 NaN APCDD1;DACT1;FZD10;FZD2;FZD7;LRP4;SFRP2;WNT9A
bosutinib Kinase inhibitor No Up Z-disc organization 0.043740316 15 NaN DES;PDLIM3
bortezomib Antiproteasome Yes Up Amyloid plaque organization 0.017593716 8 NaN HSPB6;SOD1
bortezomib Antiproteasome Yes Down Axonal intermediate filament dynamics 0.011123733 2.5 NaN NEFH;NEFL
bortezomib Antiproteasome Yes Down Cardiomyocyte pacemaker current generation 0.014598411 5.5 NaN CACNA1G;KCNJ5
bortezomib Antiproteasome Yes Up Chaperone-mediated autophagy 0.000358072 2 NaN HSP90AA1;HSPA8
bortezomib Antiproteasome Yes Up Cholesterol synthesis 0.00048019 3 NaN CYP51A1;HMGCR;HMGCS1;SQLE
bortezomib Antiproteasome Yes Up Clathrin-mediated endocytosis 0.03976104 16 NaN AAK1;CLTC;DNM1
bortezomib Antiproteasome Yes Up Cytosolic protein folding 0.018966126 9 NaN HSP90AA1
bortezomib Antiproteasome Yes Up Endoplasmic reticulum quality control system 0.042319081 17 NaN BCAP31;FBXO2;NPLOC4
bortezomib Antiproteasome Yes Up Extracellular matrix breakdown and membrane shedding by adamalysins 0.010150423 6 NaN ADAM15;ADAMTS1;ADAMTS14
bortezomib Antiproteasome Yes Down Extracellular matrix breakdown and membrane shedding by adamalysins 0.019053024 8 NaN ADAMTS15;ADAMTS7;ADAMTS8
bortezomib Antiproteasome Yes Down Extrinsic apoptosis pathway 0.011123733 2.5 NaN FAS;TNFRSF10A
bortezomib Antiproteasome Yes Up Fibroblast growth factor receptor signaling 0.02085161 10 NaN FGF1;FGF18
bortezomib Antiproteasome Yes Up Hepatocyte growth factor receptor signaling 0.037574179 14 NaN MET
bortezomib Antiproteasome Yes Down Intrinsic apoptosis pathway 0.043169865 10 NaN BMF;PMAIP1
bortezomib Antiproteasome Yes Up Lipogenesis 0.037574179 14 NaN FASN
bortezomib Antiproteasome Yes Up Multivesicular body dynamics 0.017100594 7 NaN HGS;NEDD4L;VPS37A
bortezomib Antiproteasome Yes Down Muscarinic receptor signaling 0.008072724 1 NaN CHRM4;RGS5
bortezomib Antiproteasome Yes Up NFkB signaling pathway 0.005107525 4 NaN NFKB2;SQSTM1
bortezomib Antiproteasome Yes Down Notch receptor signaling 0.011512573 4 NaN DLL4;LFNG;NOTCH1
bortezomib Antiproteasome Yes Down Nucleosome assembly 0.015014532 7 NaN ASF1B;HIST1H1D;HIST1H1E
bortezomib Antiproteasome Yes Up Proteasomal core organization 0.037574179 14 NaN PSMA7
bortezomib Antiproteasome Yes Up Proteasomal regulatory particle organization 0.000222599 1 NaN PSMC4;PSMD14;PSMD8
bortezomib Antiproteasome Yes Up Protein polyubiquitination 0.036079961 11.5 NaN UBC;UCHL1
bortezomib Antiproteasome Yes Down Pyrimidine synthesis and salvage 0.014598411 5.5 NaN TK1;TYMS
bortezomib Antiproteasome Yes Up Thin myofilament organization 0.007061495 5 NaN ACTA1;TNNI3
bortezomib Antiproteasome Yes Down Tropoelastin synthesis 0.023994354 9 NaN ELN
bortezomib Antiproteasome Yes Up Z-disc organization 0.036079961 11.5 NaN BAG3;MYPN
bevacizumab Monoclonal antibody Yes Down Adrenergic receptor signaling 0.020170501 8 8 Down by cardiotoxic TKIs RASD1;RGS16;RGS4
bevacizumab Monoclonal antibody Yes Down Aggrecan synthesis 0.022582922 11.5 NaN ACAN
bevacizumab Monoclonal antibody Yes Down Albumin mediated blood protein transport 0.022582922 11.5 NaN ALB
bevacizumab Monoclonal antibody Yes Up Biglycan synthesis 0.023200423 12.5 NaN BGN
bevacizumab Monoclonal antibody Yes Up Cardiomyocyte pacemaker current generation 0.013690263 8.5 NaN HCN4;KCNK2
bevacizumab Monoclonal antibody Yes Up CCN intercellular signaling protein family receptor signaling 0.005119846 6.5 NaN CYR61;WISP1
bevacizumab Monoclonal antibody Yes Down CD44-Mediated leukocyte rolling 0.044657802 15.5 NaN CD44
bevacizumab Monoclonal antibody Yes Up Cellular cholesterol uptake and efflux 0.035340255 15.5 NaN ABCA1;ABCA12
bevacizumab Monoclonal antibody Yes Down Collagen fibril organization by fibril-associated bridges 0.007176501 3 NaN COL12A1;COL9A2
bevacizumab Monoclonal antibody Yes Up Contractile ring constriction 0.005119846 6.5 NaN MYH14;MYLK
bevacizumab Monoclonal antibody Yes Up Eicosanoid metabolism 0.046155652 23 NaN CYP2J2;PTGES
bevacizumab Monoclonal antibody Yes Down ER unfolded protein response pathway 0.013002108 6 NaN ATF4;HERPUD1
bevacizumab Monoclonal antibody Yes Up Extracellular matrix breakdown and membrane shedding by adamalysins 0.017432245 11 NaN ADAM33;ADAMTS5;ADAMTS7
bevacizumab Monoclonal antibody Yes Up Extracellular matrix breakdown by matrix metalloproteases 0.017334623 10 NaN MMP14;MMP2
bevacizumab Monoclonal antibody Yes Down Extracellular matrix breakdown by matrix metalloproteases 0.016470005 7 NaN MMP12;MMP3
bevacizumab Monoclonal antibody Yes Up Fibrillar collagen core structure organization 5.33E-05 1 NaN COL1A1;COL1A2;COL2A1;COL3A1
bevacizumab Monoclonal antibody Yes Down Fibrillar collagen core structure organization 0.020283903 9 NaN COL11A2;COL5A1
bevacizumab Monoclonal antibody Yes Down Gap junction organization 0.038662978 14 24 Down by cardiotoxic TKIs GJA5;GJB2
bevacizumab Monoclonal antibody Yes Up Granulocyte macrophage colony-stimulating factor receptor signaling 0.045864587 19.5 NaN JAK2
bevacizumab Monoclonal antibody Yes Up Inhibin receptor signaling 0.013690263 8.5 NaN INHBA;INHBE
bevacizumab Monoclonal antibody Yes Up Inhibition of amyloid aggregation, amyloid degradation and uptake 0.001584083 3 NaN MME;PLAT
bevacizumab Monoclonal antibody Yes Up Inositol metabolism and transport 0.045864587 19.5 NaN INPP5D
bevacizumab Monoclonal antibody Yes Up Lipid droplet fusion 0.023200423 12.5 NaN CIDEC
bevacizumab Monoclonal antibody Yes Up Lipogenesis 0.045864587 19.5 NaN FASN
bevacizumab Monoclonal antibody Yes Up Methionine cycle 0.045864587 19.5 NaN BHMT
bevacizumab Monoclonal antibody Yes Up Microfibril scaffold organization 0.045864587 19.5 NaN FBN1
bevacizumab Monoclonal antibody Yes Up Osteonectin receptor signaling 0.00311962 4.5 NaN SMOC2;SPARC
bevacizumab Monoclonal antibody Yes Up Platelet-derived growth factor receptor signaling 0.025687982 14 NaN PDGFRA;PDGFRB
bevacizumab Monoclonal antibody Yes Down Polyol pathway 4.48E-05 1 4 Down by cardiotoxic TKIs AKR1A1;AKR1B10;SORD
bevacizumab Monoclonal antibody Yes Down Progesterone receptor signaling 0.022582922 11.5 NaN PGR
bevacizumab Monoclonal antibody Yes Up Prostaglandin PGF2 alpha receptor signaling 0.045864587 19.5 NaN PTGFR
bevacizumab Monoclonal antibody Yes Up Retinol metabolism 0.035340255 15.5 NaN ALDH1A2;RDH10
bevacizumab Monoclonal antibody Yes Down Roundabout signaling 0.009898099 4.5 NaN ROBO1;ROBO2
bevacizumab Monoclonal antibody Yes Down Tenascin receptor signaling 0.002957925 2 NaN TENM1;TNC
bevacizumab Monoclonal antibody Yes Down Thin myofilament organization 0.009898099 4.5 21 Down by cardiotoxic TKIs LMOD3;TPM2
bevacizumab Monoclonal antibody Yes Up Thyroid hormone receptor signaling 0.00311962 4.5 10 Up by cardiotoxic TKIs THRB;TRIP6
bevacizumab Monoclonal antibody Yes Up Tight junction organization 0.001037836 2 NaN CLDN11;CLDN6;CRB2;MPP5;MYLK
bevacizumab Monoclonal antibody Yes Down Tropoelastin synthesis 0.022582922 11.5 NaN ELN
bevacizumab Monoclonal antibody Yes Down Vasoactive intestinal peptide receptor signaling 0.044657802 15.5 NaN VIPR2
azacitidine Other chemotherapy drug No Up Adenylyl cyclase signaling pathway 0.039728723 25 NaN PDE4D;RAPGEF4
azacitidine Other chemotherapy drug No Up Aggrecan synthesis 0.017731122 16.5 NaN ACAN
azacitidine Other chemotherapy drug No Up Albumin mediated blood protein transport 0.017731122 16.5 NaN ALB
azacitidine Other chemotherapy drug No Down Alternative complement pathway 0.006449906 8 NaN C3;CFH
azacitidine Other chemotherapy drug No Down Amyloid plaque organization 0.002488588 4.5 NaN APOE;PRNP;VSNL1
azacitidine Other chemotherapy drug No Up Biglycan synthesis 0.017731122 16.5 NaN BGN
azacitidine Other chemotherapy drug No Up Cardiomyocyte depolarization during action potential 0.017731122 16.5 NaN SCN5A
azacitidine Other chemotherapy drug No Down Cardiomyocyte pacemaker current generation 0.017146691 10 NaN CACNA1D;CACNA1G
azacitidine Other chemotherapy drug No Up Cardiomyocyte repolarization during action potential and hyperpolarization 0.02474622 22 NaN KCNA1;KCNH2
azacitidine Other chemotherapy drug No Up Chloride transmembrane transport 0.021458257 21 NaN ANO1;BEST1
azacitidine Other chemotherapy drug No Down Cholesterol synthesis 8.58E-06 2 NaN DHCR24;FDPS;HMGCR;HMGCS1;MSMO1;MVD
azacitidine Other chemotherapy drug No Down Collagen fibril organization by fibril-associated bridges 6.56E-06 1 NaN COL12A1;COL14A1;COL9A1;COL9A3
azacitidine Other chemotherapy drug No Up Contractile ring constriction 0.003020133 5 NaN MYH14;MYLK
azacitidine Other chemotherapy drug No Down Decorin synthesis 0.026111503 11.5 NaN DCN
azacitidine Other chemotherapy drug No Up Fibrillar collagen core structure organization 0.012819001 12.5 NaN COL1A2;COL3A1
azacitidine Other chemotherapy drug No Down Fibrillar collagen core structure organization 8.45E-05 3 NaN COL11A1;COL2A1;COL5A1;COL5A2
azacitidine Other chemotherapy drug No Down Glutamate and glutamine metabolism 0.043842794 13 NaN SLC1A1;SLC7A5
azacitidine Other chemotherapy drug No Up Glycogen synthesis and glycogenolysis 0.031886475 23 NaN PPP1R3A;PYGM
azacitidine Other chemotherapy drug No Up Glycolysis and Gluconeogenesis 0.00748822 8 NaN GPI;PGK1;TPI1
azacitidine Other chemotherapy drug No Up Granulocyte-colony stimulating factor receptor signaling 0.010375434 11 NaN SOCS3;STAT3
azacitidine Other chemotherapy drug No Up Growth differentiation factor receptor signaling 0.008164533 9.5 NaN GDF2;GDF6
azacitidine Other chemotherapy drug No Up Inhibin receptor signaling 0.008164533 9.5 NaN INHBA;TGFBR3
azacitidine Other chemotherapy drug No Up JAK-STAT signaling pathway 0.001730476 2 NaN SOCS2;SOCS3;STAT3
azacitidine Other chemotherapy drug No Up Leptin receptor signaling 0.00183348 3.5 NaN SOCS3;STAT3
azacitidine Other chemotherapy drug No Up Microfibril scaffold organization 0.035149388 24 NaN FBN1
azacitidine Other chemotherapy drug No Up Mitochondrial fission 0.018368919 20 NaN DNM1;MTFP1
azacitidine Other chemotherapy drug No Up Natriuretic peptide receptor signaling 0.004477398 6 NaN NPPA;NPPB
azacitidine Other chemotherapy drug No Up Osteonectin receptor signaling 0.00183348 3.5 NaN SMOC2;SPARC
azacitidine Other chemotherapy drug No Down Osteopontin receptor signaling 0.026111503 11.5 NaN SPP1
azacitidine Other chemotherapy drug No Down Platelet-derived growth factor receptor signaling 0.002488588 4.5 NaN PDGFRA;RGS5;TNK2
azacitidine Other chemotherapy drug No Up Potassium transmembrane transport 0.000771738 1 NaN ATP1A3;KCNE4;KCNH2;KCNK2
azacitidine Other chemotherapy drug No Up Progesterone receptor signaling 0.017731122 16.5 NaN PGR
azacitidine Other chemotherapy drug No Down Proteasomal regulatory particle organization 0.013083845 9 NaN PSMC4;PSMD14
azacitidine Other chemotherapy drug No Up Restriction point 0.012819001 12.5 NaN CCND2;CDKN1A
azacitidine Other chemotherapy drug No Up Roundabout signaling 0.006195402 7 NaN ROBO2;ROBO3
azacitidine Other chemotherapy drug No Down Thrombospondin receptor signaling 0.003937748 6 NaN CD47;THBS4
azacitidine Other chemotherapy drug No Up Tropoelastin synthesis 0.017731122 16.5 NaN ELN
azacitidine Other chemotherapy drug No Down WNT-Beta-catenin signaling pathway 0.006346162 7 NaN CTHRC1;FRZB;PAX6;SFRP2;SFRP4;WNT2
axitinib Kinase inhibitor No Up Albumin mediated blood protein transport 0.017819337 10.5 NaN ALB
axitinib Kinase inhibitor No Down Alternative complement pathway 0.006925405 9.5 NaN C3;CFH
axitinib Kinase inhibitor No Up Antigen presentation via MHC class I molecules 0.012941091 8 NaN HLA-B;HLA-C
axitinib Kinase inhibitor No Up Axonal intermediate filament dynamics 0.006255506 5 NaN NEFM;NES
axitinib Kinase inhibitor No Down Bone morphogenetic protein receptor signaling 0.020689638 15 NaN BMP2;BMP7;CHRD
axitinib Kinase inhibitor No Down Chloride transmembrane transport 0.046834922 18 NaN SLC12A7;SLC26A8
axitinib Kinase inhibitor No Down Cholesterol synthesis 0.001813198 5 NaN DHCR7;HMGCS1;MSMO1;MVD
axitinib Kinase inhibitor No Down Class switch recombination 0.013817206 12 NaN BCL6;IL7R;IRF4
axitinib Kinase inhibitor No Down Collagen fibril organization by fibril-associated bridges 0.010202989 11 NaN COL12A1;COL9A2
axitinib Kinase inhibitor No Down Contractile ring constriction 0.006925405 9.5 NaN ANLN;MYLK
axitinib Kinase inhibitor No Up Decorin synthesis 0.017819337 10.5 NaN DCN
axitinib Kinase inhibitor No Down Desaturation of fatty acids 0.014030212 13.5 NaN FADS2;SCD
axitinib Kinase inhibitor No Up Extracellular matrix breakdown and membrane shedding by adamalysins 0.008563218 7 NaN ADAM33;ADAMTS5;ADAMTS6
axitinib Kinase inhibitor No Down Extracellular matrix breakdown and membrane shedding by adamalysins 3.35E-05 1 NaN ADAMTS1;ADAMTS12;ADAMTS14;ADAMTS15;ADAMTS2;ADAMTS7
axitinib Kinase inhibitor No Down Extracellular matrix breakdown by cathepsins 0.028496482 16 NaN CTSH;CTSV
axitinib Kinase inhibitor No Down Extracellular matrix breakdown by heparanases and sulfatases 0.004230807 8 NaN SULF1;SULF2
axitinib Kinase inhibitor No Down Extracellular matrix breakdown by matrix metalloproteases 0.001463495 4 NaN MMP14;MMP2;MMP3
axitinib Kinase inhibitor No Up Extrinsic apoptosis pathway 0.006255506 5 NaN FAS;TNFRSF10A
axitinib Kinase inhibitor No Up Fibrillar collagen core structure organization 1.89E-05 1 NaN COL11A2;COL1A1;COL1A2;COL3A1
axitinib Kinase inhibitor No Down Glutamate and glutamine metabolism 0.046834922 18 NaN SLC1A5;SLC7A5
axitinib Kinase inhibitor No Down Glycolysis and Gluconeogenesis 0.000317571 3 NaN LDHA;PCK2;PFKFB3;PFKFB4;PGK1
axitinib Kinase inhibitor No Up Granulocyte macrophage colony-stimulating factor receptor signaling 0.035322689 14.5 NaN JUND
axitinib Kinase inhibitor No Down Inhibition of amyloid aggregation, amyloid degradation and uptake 0.00215396 7 NaN A2M;PLAT
axitinib Kinase inhibitor No Up Natriuretic peptide receptor signaling 0.004521101 3 NaN NPPA;NPPB
axitinib Kinase inhibitor No Up Non-vesicular phospholipid transport 0.006255506 5 NaN PITPNB;PITPNM1
axitinib Kinase inhibitor No Down Non-vesicular phospholipid transport 0.014030212 13.5 NaN PLTP;SCP2
axitinib Kinase inhibitor No Up Notch receptor signaling 0.048646647 16 NaN DLK1;NOTCH3
axitinib Kinase inhibitor No Down Restriction point 0.002048978 6 NaN CCND1;CDKN1A;PFKFB3
axitinib Kinase inhibitor No Down Retinol metabolism 0.046834922 18 NaN ALDH1A3;DHRS3
axitinib Kinase inhibitor No Down Serine and glycine metabolism 0.000149752 2 NaN PHGDH;PSAT1;SHMT2;SLC1A5
axitinib Kinase inhibitor No Up Thin myofilament organization 0.000185089 2 NaN ACTA1;TNNI3;TPM2
axitinib Kinase inhibitor No Up Tropoelastin synthesis 0.017819337 10.5 NaN ELN
axitinib Kinase inhibitor No Up Versican receptor signaling 0.035322689 14.5 NaN VCAN
axitinib Kinase inhibitor No Up Versican synthesis 0.017819337 10.5 NaN VCAN
axitinib Kinase inhibitor No Up Z-disc organization 0.032179035 13 NaN CSRP3;PDLIM3
amiodarone Antiarrhythmic No Down Actin polymerization 0.046827129 19 NaN ABRA;ACTA1;ENAH;HSPB1
amiodarone Antiarrhythmic No Up Adenylyl cyclase signaling pathway 0.020631434 10 NaN PDE3A;RAPGEF3
amiodarone Antiarrhythmic No Up Adherens junction organization 0.014224113 9 NaN ALCAM;CGNL1;RAPGEF3
amiodarone Antiarrhythmic No Up Alternative complement pathway 1.85E-05 1 NaN C1S;C3;CFH
amiodarone Antiarrhythmic No Up Cardiomyocyte repolarization during action potential and hyperpolarization 0.012675119 8 NaN KCNIP2;KCNJ2
amiodarone Antiarrhythmic No Down CCN intercellular signaling protein family receptor signaling 0.009900042 8.5 NaN CTGF;CYR61
amiodarone Antiarrhythmic No Up Cellular cholesterol uptake and efflux 0.010952979 6 NaN ABCA1;ABCG1
amiodarone Antiarrhythmic No Up Classical complement pathway 0.003096655 5 NaN C1R;C1S
amiodarone Antiarrhythmic No Down Collagen fibril organization by fibril-associated bridges 0.014532096 13 NaN COL12A1;COL9A2
amiodarone Antiarrhythmic No Down Connection of muscle sarcomere to plasma membrane 0.040004807 17 NaN DES;SYNM
amiodarone Antiarrhythmic No Up Decorin synthesis 0.01243825 7 NaN DCN
amiodarone Antiarrhythmic No Down Epithelial intermediate filament dynamics 0.001695869 6 NaN KRT19;KRT7;KRT8
amiodarone Antiarrhythmic No Up Extracellular matrix breakdown and membrane shedding by adamalysins 0.035460509 13 NaN ADAMTS14;ADAMTS2
amiodarone Antiarrhythmic No Up Extracellular matrix breakdown by heparanases and sulfatases 0.048838754 15 NaN SULF1
amiodarone Antiarrhythmic No Up Fibrillar collagen core structure organization 0.000212048 3 NaN COL1A1;COL3A1;COL5A2
amiodarone Antiarrhythmic No Down Fibrillar collagen core structure organization 0.040004807 17 NaN COL11A1;COL2A1
amiodarone Antiarrhythmic No Down Glycogen synthesis and glycogenolysis 0.013976325 11 NaN GYG1;GYS1;PYGB
amiodarone Antiarrhythmic No Down Glycolysis and Gluconeogenesis 5.71E-06 2 NaN ALDOA;ENO1;HK2;LDHA;PGAM1;PGK1;TPI1
amiodarone Antiarrhythmic No Down Granulocyte macrophage colony-stimulating factor receptor signaling 0.0010568 4 NaN JAK2;JUND
amiodarone Antiarrhythmic No Up Hemoglobin and myoglobin synthesis 0.036855754 14 NaN MB
amiodarone Antiarrhythmic No Up Hepatocyte growth factor receptor signaling 0.024722873 11.5 NaN HGF
amiodarone Antiarrhythmic No Up Inhibition of amyloid aggregation, amyloid degradation and uptake 0.000457111 4 NaN A2M;MME
amiodarone Antiarrhythmic No Down Macrophage migration inhibitory factor signaling 0.009900042 8.5 NaN ACKR3;JUND
amiodarone Antiarrhythmic No Down Microtubule crosslinking and bundling 0.014532096 13 NaN MAP2;MTCL1
amiodarone Antiarrhythmic No Down Myofibril formation 0.040004807 17 NaN DES;XIRP1
amiodarone Antiarrhythmic No Down Natriuretic peptide receptor signaling 0.014532096 13 NaN NPPA;NPPB
amiodarone Antiarrhythmic No Down Osteopontin receptor signaling 0.032551164 15 NaN SPP1
amiodarone Antiarrhythmic No Down Recycling endosome dynamics 0.012188594 10 NaN RAB11FIP1;RAB11FIP5;RAB15;SNAP23
amiodarone Antiarrhythmic No Down Retinol metabolism 0.007672487 7 NaN ALDH1A1;ALDH1A3;STRA6
amiodarone Antiarrhythmic No Up Semaphorin signaling 5.77E-05 2 NaN NRP2;PLXNA4;PLXNC1;SEMA6A;SEMA6D
amiodarone Antiarrhythmic No Up Serotonin inactivation 0.024722873 11.5 NaN MAOA
amiodarone Antiarrhythmic No Down Thin myofilament organization 0.001086055 5 NaN ACTA1;TNNI3;TPM2
amiodarone Antiarrhythmic No Down Thrombospondin receptor signaling 0.000133563 3 NaN CD47;THBS2;THBS4
amiodarone Antiarrhythmic No Down Z-disc organization 3.25E-07 1 NaN ACTN2;CSRP3;DES;DYSF;NEXN;PDLIM3;TCAP
afatinib Kinase inhibitor No Up Actin polymerization 0.017971346 7 NaN ABRA;ACTA1;HSPB1;TMSB10
afatinib Kinase inhibitor No Down Albumin mediated blood protein transport 0.022230064 22.5 NaN ALB
afatinib Kinase inhibitor No Up Axonal intermediate filament dynamics 0.011202506 5 NaN NEFH;NEFM
afatinib Kinase inhibitor No Up Cardiomyocyte repolarization during action potential and hyperpolarization 0.043457985 12 NaN KCNIP2;KCNQ5
afatinib Kinase inhibitor No Down Cardiomyocyte repolarization during action potential and hyperpolarization 0.037567125 25 NaN KCNJ2;KCNQ1
afatinib Kinase inhibitor No Up CD44-Mediated leukocyte rolling 0.047587241 14.5 NaN CD44
afatinib Kinase inhibitor No Down Centrosome maturation 0.002058279 14 NaN AURKA;PLK1;TPX2
afatinib Kinase inhibitor No Down Centrosome separation 2.80E-10 1 NaN AURKA;CCNB1;CDK1;ESPL1;KIF11;NEK2;SPAG5
afatinib Kinase inhibitor No Up Chaperone-mediated autophagy 0.047587241 14.5 NaN HSPA8
afatinib Kinase inhibitor No Down Cholesterol synthesis 3.39E-06 3 NaN DHCR24;DHCR7;HMGCS1;MSMO1;MVD;MVK
afatinib Kinase inhibitor No Down Cholesterol-sensitive control of SREBP activation 0.006960163 19 NaN INSIG1;SREBF1
afatinib Kinase inhibitor No Down Collagen fibril organization by fibril-associated bridges 0.000206611 7.5 NaN COL9A1;COL9A2;COL9A3
afatinib Kinase inhibitor No Down Contractile ring constriction 0.004708979 17 NaN ANLN;ECT2
afatinib Kinase inhibitor No Down Equatorial RhoA activation 0.002867401 16 NaN ECT2;KIF23
afatinib Kinase inhibitor No Down Eukaryotic kinetochore dynamics 1.07E-07 2 NaN BUB1;CENPE;CENPF;CENPI;NDC80;NUF2;SPC24;TTK;ZWINT
afatinib Kinase inhibitor No Up Extracellular matrix breakdown by matrix metalloproteases 0.018603478 8 NaN MMP12;MMP3
afatinib Kinase inhibitor No Up Fibrillar collagen core structure organization 0.001462167 2 NaN COL1A1;COL5A1;COL5A2
afatinib Kinase inhibitor No Down Fibrillar collagen core structure organization 0.001160324 10 NaN COL11A1;COL11A2;COL2A1
afatinib Kinase inhibitor No Down G2 M transition checkpoint 0.002058279 14 NaN CCNB1;CDC25C;CDK1
afatinib Kinase inhibitor No Down GABA metabolism 0.006960163 19 NaN ABAT;SLC6A1
afatinib Kinase inhibitor No Up Glycolysis and Gluconeogenesis 0.01713221 6 NaN HK2;LDHA;PFKFB3
afatinib Kinase inhibitor No Up Granulocyte macrophage colony-stimulating factor receptor signaling 0.047587241 14.5 NaN JAK2
afatinib Kinase inhibitor No Down Hepatocyte growth factor receptor signaling 0.043967869 28 NaN MET
afatinib Kinase inhibitor No Down Inhibition of apoptosis 0.002058279 14 NaN BIRC5;IFI6;XAF1
afatinib Kinase inhibitor No Down Intracellular bridge assembly 0.001455058 11 NaN INCENP;KIF23
afatinib Kinase inhibitor No Down Lipogenesis 0.043967869 28 NaN FASN
afatinib Kinase inhibitor No Down Metaphase to anaphase checkpoint 7.95E-06 5 NaN BUB1;BUB1B;CCNB2;CDC20;CENPE;PTTG1;TTK
afatinib Kinase inhibitor No Down Methionine cycle 0.043967869 28 NaN BHMT
afatinib Kinase inhibitor No Down Mitotic H3 phosphorylation and dephosphorylation 0.000105033 6 NaN AURKB;CCNA2;INCENP
afatinib Kinase inhibitor No Down Mitotic spindle assembly 5.80E-06 4 NaN DLGAP5;NUSAP1;TACC3;TPX2;TTK
afatinib Kinase inhibitor No Down Mitotic spindle disassembly 0.022230064 22.5 NaN CDK1
afatinib Kinase inhibitor No Up Muscarinic receptor signaling 0.008130369 4 NaN RGS4;RGS5
afatinib Kinase inhibitor No Up Myofibril formation 0.022888806 9 NaN DES;KLHL41
afatinib Kinase inhibitor No Down Natriuretic peptide receptor signaling 0.006960163 19 NaN NPPA;NPPB
afatinib Kinase inhibitor No Up Platelet-derived growth factor receptor signaling 0.027536352 10 NaN PDGFRA;RGS5
afatinib Kinase inhibitor No Down Removal of caspase inhibition 0.043967869 28 NaN XAF1
afatinib Kinase inhibitor No Up Retinol metabolism 0.037839646 11 NaN ALDH1A2;ALDH1A3
afatinib Kinase inhibitor No Down Serine and glycine metabolism 0.00156935 12 NaN PHGDH;PSAT1;SHMT2
afatinib Kinase inhibitor No Down Sister chromatid attachment to mitotic spindle 0.000492258 9 NaN NUF2;TACC3
afatinib Kinase inhibitor No Down Sister chromatid segregation 0.000206611 7.5 NaN ESPL1;PTTG1;TOP2A
afatinib Kinase inhibitor No Down Tropoelastin synthesis 0.022230064 22.5 NaN ELN
afatinib Kinase inhibitor No Up Vasoactive intestinal peptide receptor signaling 0.047587241 14.5 NaN VIPR2
afatinib Kinase inhibitor No Down Versican receptor signaling 0.043967869 28 NaN VCAN
afatinib Kinase inhibitor No Down Versican synthesis 0.022230064 22.5 NaN VCAN
afatinib Kinase inhibitor No Up Water transmembrane transport 0.000707235 1 NaN AQP1;AQP3;AQP7
afatinib Kinase inhibitor No Up WNT-Beta-catenin signaling pathway 0.004299451 3 NaN APCDD1;DKK2;DKK3;FZD1;FZD2;FZD8