predicTox

Datasets

NaN = Not a Number/Not Determined

Drug-induced pathways in each cell line

Drug Name Drug Class Is Cardiotoxic Cardiomyocyte Line Up/Down Pathway Enrichment p-value Enrichment rank Pathway F1 score AUC rank Cardiotoxicity of pathway Pathway Genes
verapamil Antiarrhythmic Yes MSN01 Down Z-disc organization 5.96E-05 1 NaN CSRP3;DES;MYPN;PDLIM3;TCAP
verapamil Antiarrhythmic Yes MSN05 Down Z-disc organization 1.75E-07 1 NaN ACTN2;CSRP3;DES;DYSF;NEXN;PDLIM3;TCAP
verapamil Antiarrhythmic Yes MSN06 Down Z-disc organization 7.73E-08 1 NaN ACTN2;CSRP3;DES;DYSF;MYPN;PDLIM3;TCAP
verapamil Antiarrhythmic Yes MSN08 Down Z-disc organization 9.62E-05 3 NaN ACTN2;CSRP3;DES;PDLIM3;TCAP
verapamil Antiarrhythmic Yes MSN09 Down Z-disc organization 2.10E-07 2 NaN ACTN2;CSRP3;DES;DYSF;MYOZ1;PDLIM3;TCAP
verapamil Antiarrhythmic Yes MSN01 Down Mitotic spindle disassembly 0.028316867 14 NaN CDK1
verapamil Antiarrhythmic Yes MSN01 Down Myofibril formation 0.030954254 18 NaN DES;XIRP1
verapamil Antiarrhythmic Yes MSN05 Down Myofibril formation 0.033865605 20.5 NaN DES;XIRP1
verapamil Antiarrhythmic Yes MSN06 Down Myofibril formation 0.027130428 17 NaN DES;XIRP1
verapamil Antiarrhythmic Yes MSN08 Down Myofibril formation 0.037267993 20 NaN DES;XIRP1
verapamil Antiarrhythmic Yes MSN09 Down Myofibril formation 0.002883263 6.5 NaN DES;MYOZ1;XIRP1
verapamil Antiarrhythmic Yes MSN01 Down Natriuretic peptide receptor signaling 0.011119254 8 NaN NPPA;NPPB
verapamil Antiarrhythmic Yes MSN05 Down Natriuretic peptide receptor signaling 0.012210551 9.5 NaN NPPA;NPPB
verapamil Antiarrhythmic Yes MSN06 Down Natriuretic peptide receptor signaling 0.009695754 10 NaN NPPA;NPPB
verapamil Antiarrhythmic Yes MSN08 Down Natriuretic peptide receptor signaling 0.013493828 10.5 NaN NPPA;NPPB
verapamil Antiarrhythmic Yes MSN09 Down Natriuretic peptide receptor signaling 0.012844883 12 NaN NPPA;NPPB
verapamil Antiarrhythmic Yes MSN06 Up Nodal growth differentiation factor receptor signaling 0.019919132 13 NaN LEFTY2;TCEA3
verapamil Antiarrhythmic Yes MSN01 Down Non-vesicular phospholipid transport 0.015277597 11.5 NaN PITPNM1;PLTP
verapamil Antiarrhythmic Yes MSN05 Up Notch receptor signaling 0.033700302 15.5 NaN DLK1;NOTCH3
verapamil Antiarrhythmic Yes MSN06 Up Osteopontin receptor signaling 0.015790402 9.5 NaN SPP1
verapamil Antiarrhythmic Yes MSN09 Up Osteopontin receptor signaling 0.014643613 12 NaN SPP1
verapamil Antiarrhythmic Yes MSN09 Up Platelet-derived growth factor receptor signaling 0.000466725 5 NaN PDGFD;PDGFRA;PDGFRB
verapamil Antiarrhythmic Yes MSN01 Down Platelet-derived growth factor receptor signaling 0.037136486 20.5 NaN FOSL1;TNK2
verapamil Antiarrhythmic Yes MSN05 Down Potassium transmembrane transport 0.033202869 18 NaN ATP1A2;ATP1A3;FXYD1
verapamil Antiarrhythmic Yes MSN06 Down Potassium transmembrane transport 0.024408174 13 NaN ATP1A2;ATP1A3;FXYD1
verapamil Antiarrhythmic Yes MSN08 Down Potassium transmembrane transport 0.037880307 22 NaN ATP1A2;ATP1A3;FXYD1
verapamil Antiarrhythmic Yes MSN01 Up Progesterone receptor signaling 0.016231475 3.5 NaN PGR
verapamil Antiarrhythmic Yes MSN05 Down Progesterone receptor signaling 0.029728299 17 NaN PGR
verapamil Antiarrhythmic Yes MSN06 Down Progesterone receptor signaling 0.026376147 14.5 NaN PGR
verapamil Antiarrhythmic Yes MSN05 Up Prostaglandin E2 receptor signaling 0.0030397 4 NaN PTGER3;RAPGEF4
verapamil Antiarrhythmic Yes MSN05 Down Recycling endosome dynamics 0.008937543 7 NaN RAB11FIP5;RAB15;S100A10;SNAP23
verapamil Antiarrhythmic Yes MSN06 Down Recycling endosome dynamics 0.036588123 19 NaN EHD1;RAB11FIP5;RAB15
verapamil Antiarrhythmic Yes MSN05 Down Restriction point 0.033865605 20.5 NaN CCND2;CDKN1A
verapamil Antiarrhythmic Yes MSN09 Down Restriction point 0.035550215 16.5 NaN CDKN1A;PFKFB3
verapamil Antiarrhythmic Yes MSN06 Up Retinol metabolism 0.000985446 2 NaN ALDH1A2;DHRS3;RDH10
verapamil Antiarrhythmic Yes MSN05 Up Roundabout signaling 0.004214967 5 NaN ROBO1;ROBO2
verapamil Antiarrhythmic Yes MSN01 Up Semaphorin signaling 0.017405753 6 NaN PLXNC1;RND1;SEMA6D
verapamil Antiarrhythmic Yes MSN05 Up Semaphorin signaling 0.00142787 3 NaN NRP2;PLXNC1;SEMA6A;SEMA6D
verapamil Antiarrhythmic Yes MSN06 Up Semaphorin signaling 0.000178161 1 NaN NRP2;PLXNC1;PLXND1;SEMA6A;SEMA6D
verapamil Antiarrhythmic Yes MSN08 Up Semaphorin signaling 0.00142787 1 NaN NRP2;PLXNC1;SEMA6A;SEMA6D
verapamil Antiarrhythmic Yes MSN09 Up Semaphorin signaling 0.001460037 6 NaN NRP2;PLXNC1;SEMA6A;SEMA6D
verapamil Antiarrhythmic Yes MSN05 Down Serine and glycine metabolism 0.00359729 4 NaN PHGDH;SHMT2;SLC1A5
verapamil Antiarrhythmic Yes MSN08 Down Serine and glycine metabolism 0.004166579 6 NaN PHGDH;PSAT1;SHMT2
verapamil Antiarrhythmic Yes MSN06 Up Serotonin inactivation 0.031332839 14.5 NaN MAOA
verapamil Antiarrhythmic Yes MSN09 Up Serotonin inactivation 0.029074064 18 NaN MAOA
verapamil Antiarrhythmic Yes MSN09 Up Sister chromatid attachment to mitotic spindle 0.029074064 18 NaN NUF2
verapamil Antiarrhythmic Yes MSN09 Up Sister chromatid segregation 0.003076041 8 NaN PTTG1;TOP2A
verapamil Antiarrhythmic Yes MSN01 Down Sister chromatid segregation 0.011119254 8 NaN PTTG1;TOP2A
verapamil Antiarrhythmic Yes MSN06 Up Sodium transmembrane transport 0.001530203 3 NaN SCN1A;SCN2A;SCN3A;SCN9A
verapamil Antiarrhythmic Yes MSN01 Down Syndecan receptor signaling 0.007553576 4.5 NaN SDC1;SDC3
verapamil Antiarrhythmic Yes MSN06 Down Syndecan receptor signaling 0.006578004 7.5 NaN SDC3;SDC4
verapamil Antiarrhythmic Yes MSN08 Down Syndecan receptor signaling 0.009185114 8 NaN SDC3;SDC4
verapamil Antiarrhythmic Yes MSN09 Down Syndecan receptor signaling 0.008738735 10 NaN SDC3;SDC4
verapamil Antiarrhythmic Yes MSN01 Down Thin myofilament organization 0.015277597 11.5 NaN ACTA1;TNNI3
verapamil Antiarrhythmic Yes MSN05 Down Thin myofilament organization 0.016761242 12.5 NaN ACTA1;TNNI3
verapamil Antiarrhythmic Yes MSN06 Down Thin myofilament organization 1.56E-05 3 NaN ACTA1;LMOD3;TNNI3;TPM2
verapamil Antiarrhythmic Yes MSN08 Down Thin myofilament organization 0.018503192 13.5 NaN ACTA1;TNNI3
verapamil Antiarrhythmic Yes MSN09 Down Thin myofilament organization 0.000900451 3 NaN ACTA1;TNNI3;TPM2
verapamil Antiarrhythmic Yes MSN05 Down Thrombospondin receptor signaling 0.005081293 5 NaN THBS2;THBS4
verapamil Antiarrhythmic Yes MSN06 Down Thrombospondin receptor signaling 0.004016669 6 NaN THBS2;THBS4
verapamil Antiarrhythmic Yes MSN05 Down Tight junction organization 0.017618286 14 NaN CLDN6;CRB2;MPP5;MYLK
verapamil Antiarrhythmic Yes MSN06 Up Tropoelastin synthesis 0.015790402 9.5 NaN ELN
verapamil Antiarrhythmic Yes MSN09 Up Tropoelastin synthesis 0.014643613 12 NaN ELN
verapamil Antiarrhythmic Yes MSN08 Down Tropoelastin synthesis 0.031316161 16.5 NaN ELN
verapamil Antiarrhythmic Yes MSN05 Up Versican receptor signaling 0.028900203 13.5 NaN VCAN
verapamil Antiarrhythmic Yes MSN06 Up Versican receptor signaling 0.031332839 14.5 NaN VCAN
verapamil Antiarrhythmic Yes MSN08 Up Versican receptor signaling 0.028900203 8.5 NaN VCAN
verapamil Antiarrhythmic Yes MSN05 Up Versican synthesis 0.014555399 9 NaN VCAN
verapamil Antiarrhythmic Yes MSN06 Up Versican synthesis 0.015790402 9.5 NaN VCAN
verapamil Antiarrhythmic Yes MSN08 Up Versican synthesis 0.014555399 4.5 NaN VCAN
verapamil Antiarrhythmic Yes MSN09 Down Water transmembrane transport 0.02302747 15 NaN AQP10;AQP3
verapamil Antiarrhythmic Yes MSN05 Down Actin filament bundling and crosslinking 0.040847464 23 NaN ACTN2;SYNPO;TAGLN
verapamil Antiarrhythmic Yes MSN09 Down Actin filament bundling and crosslinking 0.007494453 8 NaN ACTN2;FLNB;SYNPO;TAGLN
verapamil Antiarrhythmic Yes MSN01 Down Actin polymerization 0.030357852 16 NaN ABRA;ACTA1;ENAH;HSPB1
verapamil Antiarrhythmic Yes MSN08 Down Actin polymerization 0.041593261 23 NaN ABRA;ACTA1;MAL2;VAV3
verapamil Antiarrhythmic Yes MSN09 Down Actin polymerization 0.038416284 19 NaN ABRA;ACTA1;ENAH;HSPB1
verapamil Antiarrhythmic Yes MSN01 Up Adenylyl cyclase signaling pathway 0.03380839 10 NaN PDE3A;PDE4D
verapamil Antiarrhythmic Yes MSN05 Up Adenylyl cyclase signaling pathway 0.027655274 12 NaN PDE3A;RAPGEF4
verapamil Antiarrhythmic Yes MSN08 Down Aggrecan synthesis 0.031316161 16.5 NaN ACAN
verapamil Antiarrhythmic Yes MSN05 Up Albumin mediated blood protein transport 0.014555399 9 NaN ALB
verapamil Antiarrhythmic Yes MSN08 Down Albumin mediated blood protein transport 0.031316161 16.5 NaN ALB
verapamil Antiarrhythmic Yes MSN08 Up Alternative complement pathway 0.002046016 2 NaN C1S;C3
verapamil Antiarrhythmic Yes MSN09 Up Alternative complement pathway 0.002070599 7 NaN C1S;C3
verapamil Antiarrhythmic Yes MSN01 Down Amyloid plaque organization 0.037136486 20.5 NaN APOE;HSPB6
verapamil Antiarrhythmic Yes MSN06 Down Antigen presentation via MHC class I molecules 0.027130428 17 NaN HLA-A;HLA-C
verapamil Antiarrhythmic Yes MSN09 Down Antigen presentation via MHC class I molecules 0.035550215 16.5 NaN HLA-A;HLA-C
verapamil Antiarrhythmic Yes MSN05 Down Aspartate and arginine metabolism 0.033865605 20.5 NaN DDAH1;SLC7A1
verapamil Antiarrhythmic Yes MSN08 Down Aspartate and arginine metabolism 0.037267993 20 NaN ARG2;SLC7A1
verapamil Antiarrhythmic Yes MSN08 Down Basement membrane attachment to cell surface 0.013493828 10.5 NaN CD151;ITGA5
verapamil Antiarrhythmic Yes MSN01 Up Biglycan synthesis 0.016231475 3.5 NaN BGN
verapamil Antiarrhythmic Yes MSN08 Up Biglycan synthesis 0.014555399 4.5 NaN BGN
verapamil Antiarrhythmic Yes MSN06 Down Cardiomyocyte depolarization during action potential 0.026376147 14.5 NaN SCN5A
verapamil Antiarrhythmic Yes MSN05 Up Cardiomyocyte pacemaker current generation 0.005566383 6 NaN CACNA1D;CACNA1G
verapamil Antiarrhythmic Yes MSN06 Up Cardiomyocyte pacemaker current generation 0.006521753 6 NaN CACNA1D;CACNA1G
verapamil Antiarrhythmic Yes MSN01 Up Cardiomyocyte repolarization during action potential and hyperpolarization 0.020976831 7 NaN KCNIP2;KCNJ2
verapamil Antiarrhythmic Yes MSN08 Up Cardiomyocyte repolarization during action potential and hyperpolarization 0.017084419 7 NaN KCNIP2;KCNJ2
verapamil Antiarrhythmic Yes MSN09 Up Cardiomyocyte repolarization during action potential and hyperpolarization 0.017280609 15.5 NaN KCNIP2;KCNJ2
verapamil Antiarrhythmic Yes MSN01 Down CCN intercellular signaling protein family receptor signaling 0.007553576 4.5 NaN CTGF;CYR61
verapamil Antiarrhythmic Yes MSN05 Up Cellular cholesterol uptake and efflux 0.014783725 11 NaN ABCA1;ABCG1
verapamil Antiarrhythmic Yes MSN06 Up Cellular cholesterol uptake and efflux 0.017250642 12 NaN ABCA1;ABCG1
verapamil Antiarrhythmic Yes MSN08 Up Cellular cholesterol uptake and efflux 0.014783725 6 NaN ABCA1;ABCG1
verapamil Antiarrhythmic Yes MSN09 Up Cellular cholesterol uptake and efflux 0.014954359 14 NaN ABCA1;ABCG1
verapamil Antiarrhythmic Yes MSN01 Down Centrosome maturation 0.043745388 22.5 NaN PLK1;TPX2
verapamil Antiarrhythmic Yes MSN09 Up Centrosome separation 0.00034312 4 NaN CCNB1;KIF11;NEK2
verapamil Antiarrhythmic Yes MSN01 Down Centrosome separation 0.030954254 18 NaN CCNB1;CDK1
verapamil Antiarrhythmic Yes MSN05 Down Cholesterol synthesis 1.07E-06 2 NaN CYP51A1;DHCR24;DHCR7;HMGCR;MSMO1;NSDHL;SQLE
verapamil Antiarrhythmic Yes MSN09 Down Cholesterol synthesis 0.021860488 14 NaN DHCR7;MSMO1;MVD
verapamil Antiarrhythmic Yes MSN06 Up Cholesterol-sensitive control of SREBP activation 0.003567273 4.5 NaN INSIG1;SREBF1
verapamil Antiarrhythmic Yes MSN06 Down Citric acid cycle 0.044651224 20 NaN ACO2;IDH2
verapamil Antiarrhythmic Yes MSN08 Up Classical complement pathway 0.004214967 3 NaN C1R;C1S
verapamil Antiarrhythmic Yes MSN09 Up Classical complement pathway 0.004265108 9 NaN C1R;C1S
verapamil Antiarrhythmic Yes MSN01 Down Collagen fiber crosslinking 0.007553576 4.5 NaN LOXL1;PXDN
verapamil Antiarrhythmic Yes MSN06 Up Collagen fibril organization by fibril-associated bridges 0.003567273 4.5 NaN COL14A1;COL9A3
verapamil Antiarrhythmic Yes MSN05 Down Collagen fibril organization by fibril-associated bridges 0.012210551 9.5 NaN COL12A1;COL9A2
verapamil Antiarrhythmic Yes MSN08 Down Collagen fibril organization by fibril-associated bridges 0.013493828 10.5 NaN COL12A1;COL9A2
verapamil Antiarrhythmic Yes MSN05 Down Connection of muscle sarcomere to plasma membrane 0.033865605 20.5 NaN DES;SYNM
verapamil Antiarrhythmic Yes MSN06 Down Connection of muscle sarcomere to plasma membrane 0.027130428 17 NaN DES;SYNM
verapamil Antiarrhythmic Yes MSN08 Down Connection of muscle sarcomere to plasma membrane 0.037267993 20 NaN DES;SYNM
verapamil Antiarrhythmic Yes MSN09 Down Connection of muscle sarcomere to plasma membrane 0.002883263 6.5 NaN DES;ILK;SYNM
verapamil Antiarrhythmic Yes MSN01 Up Decorin synthesis 0.016231475 3.5 NaN DCN
verapamil Antiarrhythmic Yes MSN05 Up Decorin synthesis 0.014555399 9 NaN DCN
verapamil Antiarrhythmic Yes MSN06 Up Decorin synthesis 0.015790402 9.5 NaN DCN
verapamil Antiarrhythmic Yes MSN08 Down Decorin synthesis 0.031316161 16.5 NaN DCN
verapamil Antiarrhythmic Yes MSN05 Down Desaturation of fatty acids 0.016761242 12.5 NaN FADS3;SCD
verapamil Antiarrhythmic Yes MSN01 Up Discoidin domain receptor signaling 0.047912477 13.5 NaN DDR2
verapamil Antiarrhythmic Yes MSN08 Up Discoidin domain receptor signaling 0.043037442 11.5 NaN DDR2
verapamil Antiarrhythmic Yes MSN08 Up Elastin cross-linking and assembly 0.043037442 11.5 NaN LOX
verapamil Antiarrhythmic Yes MSN01 Down Epithelial intermediate filament dynamics 0.019992392 13 NaN KRT19;KRT8
verapamil Antiarrhythmic Yes MSN05 Down Epithelial intermediate filament dynamics 0.02191339 15 NaN KRT7;KRT8
verapamil Antiarrhythmic Yes MSN06 Down Epithelial intermediate filament dynamics 0.017477983 12 NaN KRT7;KRT8
verapamil Antiarrhythmic Yes MSN08 Down Epithelial intermediate filament dynamics 5.99E-05 2 NaN KRT19;KRT7;KRT8;TCHH
verapamil Antiarrhythmic Yes MSN09 Down Epithelial intermediate filament dynamics 0.001408213 5 NaN KRT19;KRT7;KRT8
verapamil Antiarrhythmic Yes MSN09 Up Eukaryotic kinetochore dynamics 1.10E-06 1 NaN BUB1;CENPE;CENPF;MAD2L1;NDC80;NUF2;TTK
verapamil Antiarrhythmic Yes MSN05 Up Extracellular matrix breakdown and membrane shedding by adamalysins 0.000366348 2 NaN ADAMTS1;ADAMTS10;ADAMTS14;ADAMTS6
verapamil Antiarrhythmic Yes MSN08 Up Extracellular matrix breakdown and membrane shedding by adamalysins 0.047145108 14 NaN ADAM12;ADAMTS1
verapamil Antiarrhythmic Yes MSN09 Up Extracellular matrix breakdown and membrane shedding by adamalysins 0.004978893 10 NaN ADAM33;ADAMTS14;ADAMTS5
verapamil Antiarrhythmic Yes MSN01 Up Fibrillar collagen core structure organization 0.000464199 1 NaN COL11A1;COL1A2;COL5A2
verapamil Antiarrhythmic Yes MSN01 Down Fibrillar collagen core structure organization 0.030954254 18 NaN COL2A1;COL3A1
verapamil Antiarrhythmic Yes MSN01 Up Fibrillin synthesis 0.047912477 13.5 NaN FBN1
verapamil Antiarrhythmic Yes MSN05 Up Fibroblast growth factor receptor signaling 0.012628988 7 NaN ANOS1;FGF10
verapamil Antiarrhythmic Yes MSN06 Up Fibroblast growth factor receptor signaling 0.014748304 7 NaN ANOS1;FGF18
verapamil Antiarrhythmic Yes MSN05 Down Fibronectin synthesis and extracellular assembly 0.008302765 6 NaN FN1;ITGB3
verapamil Antiarrhythmic Yes MSN08 Up Fibulin receptor signaling 0.028900203 8.5 NaN FBLN1
verapamil Antiarrhythmic Yes MSN09 Up Fibulin receptor signaling 0.029074064 18 NaN FBLN1
verapamil Antiarrhythmic Yes MSN01 Down Filopodium organization 0.029320646 15 NaN ENAH;MYL9;TNK2
verapamil Antiarrhythmic Yes MSN09 Down Focal adhesion organization 0.035582818 18 NaN CSRP1;ILK;RND3;ZYX
verapamil Antiarrhythmic Yes MSN01 Down G2 M transition checkpoint 0.043745388 22.5 NaN CCNB1;CDK1
verapamil Antiarrhythmic Yes MSN09 Up Gap junction organization 0.017280609 15.5 NaN GJA1;GJA5
verapamil Antiarrhythmic Yes MSN01 Down Glycolysis and Gluconeogenesis 0.003649528 2 NaN ENO1;HK2;LDHA;TPI1
verapamil Antiarrhythmic Yes MSN05 Down Glycolysis and Gluconeogenesis 0.029688885 16 NaN ENO1;HK2;LDHA
verapamil Antiarrhythmic Yes MSN06 Down Glycolysis and Gluconeogenesis 1.41E-06 2 NaN ALDOA;ENO1;HK2;LDHA;PGAM1;PGK1;TPI1
verapamil Antiarrhythmic Yes MSN08 Down Glycolysis and Gluconeogenesis 4.43E-06 1 NaN ALDOA;ENO1;GPI;LDHA;PCK2;PGK1;TPI1
verapamil Antiarrhythmic Yes MSN09 Down Glycolysis and Gluconeogenesis 5.41E-13 1 NaN ALDOA;ENO1;GPI;HK2;LDHA;PFKFB3;PFKFB4;PFKL;PFKP;PGAM1;PGK1;TPI1
verapamil Antiarrhythmic Yes MSN01 Up G-protein coupled receptor signaling pathway 0.041109436 11 NaN PDE4D;RGS4
verapamil Antiarrhythmic Yes MSN05 Up G-protein coupled receptor signaling pathway 0.033700302 15.5 NaN GRK5;RGS6
verapamil Antiarrhythmic Yes MSN05 Down Granulocyte macrophage colony-stimulating factor receptor signaling 0.000881227 3 NaN JAK2;JUND
verapamil Antiarrhythmic Yes MSN06 Down Granulocyte macrophage colony-stimulating factor receptor signaling 0.000693436 4 NaN JAK2;JUND
verapamil Antiarrhythmic Yes MSN08 Down Granulocyte macrophage colony-stimulating factor receptor signaling 0.000978026 4 NaN JAK2;JUND
verapamil Antiarrhythmic Yes MSN09 Down Granulocyte macrophage colony-stimulating factor receptor signaling 0.000928996 4 NaN JAK2;JUND
verapamil Antiarrhythmic Yes MSN08 Down Growth differentiation factor receptor signaling 0.001516721 5 NaN GDF11;GDF2;GDF6
verapamil Antiarrhythmic Yes MSN08 Down Hemidesmosome organization 0.018503192 13.5 NaN CD151;ITGB4
verapamil Antiarrhythmic Yes MSN01 Up Hemoglobin and myoglobin synthesis 0.047912477 13.5 NaN MB
verapamil Antiarrhythmic Yes MSN05 Up Hemoglobin and myoglobin synthesis 0.043037442 17 NaN MB
verapamil Antiarrhythmic Yes MSN08 Up Hemoglobin and myoglobin synthesis 0.043037442 11.5 NaN MB
verapamil Antiarrhythmic Yes MSN09 Up Hemoglobin and myoglobin synthesis 0.043294437 20 NaN MB
verapamil Antiarrhythmic Yes MSN01 Up Hepatocyte growth factor receptor signaling 0.032200898 8.5 NaN HGF
verapamil Antiarrhythmic Yes MSN09 Up Hyaluronan-mediated motility receptor signaling 0.014643613 12 NaN HMMR
verapamil Antiarrhythmic Yes MSN01 Up Inhibition of amyloid aggregation, amyloid degradation and uptake 0.047912477 13.5 NaN A2M
verapamil Antiarrhythmic Yes MSN05 Up Inhibition of amyloid aggregation, amyloid degradation and uptake 3.03E-06 1 NaN A2M;MME;PLAT
verapamil Antiarrhythmic Yes MSN06 Down Inhibition of apoptosis 0.003348691 5 NaN IFI6;PEA15;XAF1
verapamil Antiarrhythmic Yes MSN08 Down JAK-STAT signaling pathway 0.008572798 7 NaN SOCS2;SOCS3;STAT4
verapamil Antiarrhythmic Yes MSN09 Down JAK-STAT signaling pathway 0.007987951 9 NaN SOCS2;SOCS3;STAT4
verapamil Antiarrhythmic Yes MSN01 Down Lectin complement pathway 0.007553576 4.5 NaN COLEC11;MASP1
verapamil Antiarrhythmic Yes MSN01 Up Lipid droplet fusion 0.016231475 3.5 NaN CIDEC
verapamil Antiarrhythmic Yes MSN08 Up Lysine metabolism 0.043037442 11.5 NaN LOX
verapamil Antiarrhythmic Yes MSN06 Down Macrophage migration inhibitory factor signaling 0.006578004 7.5 NaN ACKR3;JUND
verapamil Antiarrhythmic Yes MSN09 Up Metaphase to anaphase checkpoint 8.62E-06 2 NaN BUB1;CCNB2;CENPE;MAD2L1;PTTG1;TTK
verapamil Antiarrhythmic Yes MSN01 Down Metaphase to anaphase checkpoint 0.014985954 10 NaN BUB1;CDC20;LZTS1;PTTG1
verapamil Antiarrhythmic Yes MSN01 Up Microfibril scaffold organization 0.032200898 8.5 NaN FBN1
verapamil Antiarrhythmic Yes MSN05 Up Microfibril scaffold organization 0.028900203 13.5 NaN MFAP2
verapamil Antiarrhythmic Yes MSN01 Down Microtubule crosslinking and bundling 0.011119254 8 NaN MAP2;MTCL1
verapamil Antiarrhythmic Yes MSN05 Down Microtubule crosslinking and bundling 0.012210551 9.5 NaN MAP2;MTCL1
verapamil Antiarrhythmic Yes MSN06 Down Microtubule crosslinking and bundling 0.009695754 10 NaN MAP2;MTCL1
verapamil Antiarrhythmic Yes MSN08 Down Microtubule crosslinking and bundling 0.013493828 10.5 NaN MAP2;MTCL1
verapamil Antiarrhythmic Yes MSN09 Down Microtubule crosslinking and bundling 0.012844883 12 NaN MAP2;MTCL1
verapamil Antiarrhythmic Yes MSN05 Down Microtubule polymerization 0.012210551 9.5 NaN MAP4;TUBA1A
verapamil Antiarrhythmic Yes MSN06 Down Microtubule polymerization 0.009695754 10 NaN MAP4;TUBA1A
verapamil Antiarrhythmic Yes MSN09 Down Microtubule polymerization 0.012844883 12 NaN MAP4;TUBA1A
verapamil Antiarrhythmic Yes MSN09 Up Mitotic spindle assembly 2.86E-05 3 NaN DLGAP5;NUSAP1;TPX2;TTK
vemurafenib Kinase inhibitor No MSN05 Up Extracellular matrix breakdown and membrane shedding by adamalysins 0.001561493 2 NaN ADAM19;ADAMTS5;ADAMTS6;ADAMTS7
vemurafenib Kinase inhibitor No MSN01 Down Extracellular matrix breakdown and membrane shedding by adamalysins 0.018503677 13 NaN ADAMTS14;ADAMTS15;ADAMTS8
vemurafenib Kinase inhibitor No MSN05 Down Extracellular matrix breakdown and membrane shedding by adamalysins 0.001682921 6 NaN ADAMTS14;ADAMTS15;ADAMTS2;ADAMTS8
vemurafenib Kinase inhibitor No MSN06 Down Extracellular matrix breakdown and membrane shedding by adamalysins 0.000287499 2 NaN ADAMTS1;ADAMTS14;ADAMTS15;ADAMTS8;ADAMTS9
vemurafenib Kinase inhibitor No MSN08 Down Extracellular matrix breakdown and membrane shedding by adamalysins 1.59E-05 2 NaN ADAMTS14;ADAMTS15;ADAMTS17;ADAMTS5;ADAMTS8;ADAMTS9
vemurafenib Kinase inhibitor No MSN09 Down Extracellular matrix breakdown and membrane shedding by adamalysins 0.001446344 5 NaN ADAM12;ADAMTS14;ADAMTS15;ADAMTS8
vemurafenib Kinase inhibitor No MSN01 Down Extracellular matrix breakdown by matrix metalloproteases 0.01809121 12 NaN MMP1;MMP3
vemurafenib Kinase inhibitor No MSN05 Down Extracellular matrix breakdown by matrix metalloproteases 0.015505928 10 NaN MMP1;MMP3
vemurafenib Kinase inhibitor No MSN09 Up Extracellular matrix breakdown by serine proteases 0.009455468 4.5 NaN KLK5;PRSS8
vemurafenib Kinase inhibitor No MSN01 Up Fibrillar collagen core structure organization 7.16E-07 1 NaN COL11A2;COL1A1;COL1A2;COL5A1;COL5A2
vemurafenib Kinase inhibitor No MSN05 Up Fibrillar collagen core structure organization 1.00E-06 1 NaN COL11A2;COL1A1;COL1A2;COL5A1;COL5A2
vemurafenib Kinase inhibitor No MSN06 Up Fibrillar collagen core structure organization 2.89E-05 1 NaN COL11A2;COL1A1;COL1A2;COL5A2
vemurafenib Kinase inhibitor No MSN08 Up Fibrillar collagen core structure organization 0.01910546 7 NaN COL1A1;COL1A2
vemurafenib Kinase inhibitor No MSN09 Up Fibrillar collagen core structure organization 4.37E-05 2 NaN COL11A2;COL1A1;COL1A2;COL5A2
vemurafenib Kinase inhibitor No MSN01 Down Fibrillar collagen core structure organization 0.001401225 3 NaN COL11A1;COL2A1;COL5A3
vemurafenib Kinase inhibitor No MSN06 Down Fibrillar collagen core structure organization 0.025134697 14.5 NaN COL11A1;COL2A1
vemurafenib Kinase inhibitor No MSN08 Down Fibrillar collagen core structure organization 0.001401225 5 NaN COL11A1;COL2A1;COL5A3
vemurafenib Kinase inhibitor No MSN09 Down Fibrillar collagen core structure organization 0.00098321 3 NaN COL11A1;COL2A1;COL5A3
vemurafenib Kinase inhibitor No MSN08 Down Fibroblast growth factor receptor signaling 0.031652619 16.5 NaN ANOS1;FGF18
vemurafenib Kinase inhibitor No MSN06 Up GABA metabolism 0.0055816 4 NaN ABAT;SLC6A1
vemurafenib Kinase inhibitor No MSN05 Up Gap junction organization 0.035147755 11 NaN GJA5;GJA8
vemurafenib Kinase inhibitor No MSN06 Up Gap junction organization 0.002388906 3 NaN GJA1;GJA5;GJA8
vemurafenib Kinase inhibitor No MSN08 Up Gap junction organization 0.03648388 13.5 NaN GJA1;GJA8
vemurafenib Kinase inhibitor No MSN09 Up Gap junction organization 0.037023918 12 NaN GJA5;GJA8
vemurafenib Kinase inhibitor No MSN08 Down Glutamate and glutamine metabolism 0.036831666 19 NaN SLC1A5;SLC7A5
vemurafenib Kinase inhibitor No MSN01 Down Glycolysis and Gluconeogenesis 0.01647391 11 NaN ENO1;LDHA;PFKFB3
vemurafenib Kinase inhibitor No MSN06 Down Granulocyte-colony stimulating factor receptor signaling 0.020445489 12.5 NaN SOCS3;STAT3
vemurafenib Kinase inhibitor No MSN08 Down Heparin and heparan sulfate synthesis 0.022263706 13.5 NaN GLCE;HS6ST1
vemurafenib Kinase inhibitor No MSN01 Up Hepatocyte growth factor receptor signaling 0.039650143 13 NaN MET
vemurafenib Kinase inhibitor No MSN05 Up Hepatocyte growth factor receptor signaling 0.042414608 13.5 NaN MET
vemurafenib Kinase inhibitor No MSN09 Up Hepatocyte growth factor receptor signaling 0.043622809 14 NaN MET
vemurafenib Kinase inhibitor No MSN01 Down Hepatocyte growth factor receptor signaling 0.046898366 17 NaN HGF
vemurafenib Kinase inhibitor No MSN05 Down Hepatocyte growth factor receptor signaling 0.043277686 12.5 NaN HGF
vemurafenib Kinase inhibitor No MSN08 Down Hepatocyte growth factor receptor signaling 0.046898366 21 NaN HGF
vemurafenib Kinase inhibitor No MSN09 Down Hepatocyte growth factor receptor signaling 0.041551141 15 NaN HGF
vemurafenib Kinase inhibitor No MSN06 Down HIF-1 receptor signaling pathway 0.020445489 12.5 NaN CITED2;EGLN3
vemurafenib Kinase inhibitor No MSN05 Down Hyaluronan synthesis 0.001409479 4.5 NaN HAS2;HAS3
vemurafenib Kinase inhibitor No MSN09 Down Hyaluronan synthesis 0.001298656 4 NaN HAS2;HAS3
vemurafenib Kinase inhibitor No MSN06 Down Inhibin receptor signaling 0.016169721 10.5 NaN INHA;INHBA
vemurafenib Kinase inhibitor No MSN08 Down Inhibin receptor signaling 0.014292788 11.5 NaN INHA;INHBA
vemurafenib Kinase inhibitor No MSN01 Down Inhibition of amyloid aggregation, amyloid degradation and uptake 0.001656732 4 NaN A2M;MME
vemurafenib Kinase inhibitor No MSN05 Down Inhibition of amyloid aggregation, amyloid degradation and uptake 0.001409479 4.5 NaN A2M;MME
vemurafenib Kinase inhibitor No MSN06 Down Inhibition of amyloid aggregation, amyloid degradation and uptake 0.001884281 4.5 NaN A2M;MME
vemurafenib Kinase inhibitor No MSN08 Down Inhibition of amyloid aggregation, amyloid degradation and uptake 0.001656732 6 NaN A2M;MME
vemurafenib Kinase inhibitor No MSN01 Down Inhibition of apoptosis 0.031652619 15 NaN BIRC5;IFI6
vemurafenib Kinase inhibitor No MSN08 Down Inhibition of apoptosis 0.031652619 16.5 NaN BIRC3;IFI6
vemurafenib Kinase inhibitor No MSN08 Up Inositol metabolism and transport 0.043277686 16 NaN INPP5D
vemurafenib Kinase inhibitor No MSN01 Up JAK-STAT signaling pathway 0.031008959 10 NaN SOCS2;STAT4
vemurafenib Kinase inhibitor No MSN06 Down JAK-STAT signaling pathway 0.004751696 7 NaN SOCS3;STAT3;STAT4
vemurafenib Kinase inhibitor No MSN06 Down Leptin receptor signaling 0.003705518 6 NaN SOCS3;STAT3
vemurafenib Kinase inhibitor No MSN01 Down Lipogenesis 0.046898366 17 NaN FASN
vemurafenib Kinase inhibitor No MSN05 Down Lipogenesis 0.043277686 12.5 NaN FASN
vemurafenib Kinase inhibitor No MSN06 Down Lipogenesis 0.049996342 20.5 NaN FASN
vemurafenib Kinase inhibitor No MSN08 Down Lipogenesis 0.000561055 3.5 NaN ACLY;FASN
vemurafenib Kinase inhibitor No MSN01 Down Macrophage migration inhibitory factor signaling 0.005350837 7.5 NaN ACKR3;CXCR4
vemurafenib Kinase inhibitor No MSN08 Down MAPK signaling pathway 0.033465072 18 NaN DUSP1;RPS6KA2;TRIM45
vemurafenib Kinase inhibitor No MSN05 Up Methionine cycle 0.042414608 13.5 NaN BHMT
vemurafenib Kinase inhibitor No MSN09 Up Methionine cycle 0.043622809 14 NaN BHMT
vemurafenib Kinase inhibitor No MSN09 Down Methionine cycle 0.041551141 15 NaN MAT1A
vemurafenib Kinase inhibitor No MSN08 Down Microtubule crosslinking and bundling 0.007900936 9 NaN MAP2;MTCL1
vemurafenib Kinase inhibitor No MSN06 Down Natriuretic peptide receptor signaling 0.008957388 9 NaN NPPB;NPR3
vemurafenib Kinase inhibitor No MSN08 Down Natriuretic peptide receptor signaling 0.007900936 9 NaN NPPB;NPR3
vemurafenib Kinase inhibitor No MSN06 Up Osteonectin receptor signaling 0.00229214 2 NaN SMOC2;SPOCK1
vemurafenib Kinase inhibitor No MSN08 Up Osteonectin receptor signaling 4.07E-05 1.5 NaN SMOC2;SPARC;SPOCK1
vemurafenib Kinase inhibitor No MSN01 Up Osteopontin receptor signaling 0.0200247 6.5 NaN SPP1
vemurafenib Kinase inhibitor No MSN05 Up Osteopontin receptor signaling 0.021436133 7.5 NaN SPP1
vemurafenib Kinase inhibitor No MSN06 Up Osteopontin receptor signaling 0.019848271 8 NaN SPP1
vemurafenib Kinase inhibitor No MSN08 Up Osteopontin receptor signaling 0.021877205 9.5 NaN SPP1
vemurafenib Kinase inhibitor No MSN09 Up Osteopontin receptor signaling 0.022053634 9.5 NaN SPP1
vemurafenib Kinase inhibitor No MSN09 Down Platelet-derived growth factor receptor signaling 0.021308064 11 NaN PDGFD;TNK2
vemurafenib Kinase inhibitor No MSN08 Up Progesterone receptor signaling 0.021877205 9.5 NaN PGR
vemurafenib Kinase inhibitor No MSN09 Down Prostaglandin E2 receptor signaling 0.006227501 8.5 NaN PTGER3;RAPGEF4
vemurafenib Kinase inhibitor No MSN08 Up Regulation of coagulation cascade by protein C 0.00277824 4 NaN PROS1;THBD
vemurafenib Kinase inhibitor No MSN09 Up Restriction point 0.019397192 7 NaN CCND2;E2F1
vemurafenib Kinase inhibitor No MSN01 Down Restriction point 0.022263706 14 NaN CDKN1A;PFKFB3
vemurafenib Kinase inhibitor No MSN01 Down Retinol metabolism 0.003167864 5 NaN ALDH1A3;RDH10;TTR
vemurafenib Kinase inhibitor No MSN05 Down Retinol metabolism 5.37E-06 1 NaN ALDH1A3;CYP26A1;RDH10;RPE65;TTR
vemurafenib Kinase inhibitor No MSN06 Down Retinol metabolism 0.041452288 19 NaN RDH10;RPE65
vemurafenib Kinase inhibitor No MSN09 Down Retinol metabolism 0.002236525 6 NaN RDH10;RPE65;TTR
vemurafenib Kinase inhibitor No MSN08 Down Semaphorin signaling 0.04605371 20 NaN DPYSL3;NRP2;SEMA3C
vemurafenib Kinase inhibitor No MSN08 Up Serine and glycine metabolism 0.023018072 12 NaN PHGDH;PSAT1
vemurafenib Kinase inhibitor No MSN08 Down Serine and glycine metabolism 0.02679052 15 NaN SHMT2;SLC1A5
vemurafenib Kinase inhibitor No MSN01 Down Serotonin inactivation 0.000561055 2 NaN MAOA;MAOB
vemurafenib Kinase inhibitor No MSN05 Down Serotonin inactivation 0.000476724 3 NaN MAOA;MAOB
vemurafenib Kinase inhibitor No MSN06 Down Serotonin inactivation 0.000638802 3 NaN MAOA;MAOB
vemurafenib Kinase inhibitor No MSN08 Down Serotonin inactivation 0.000561055 3.5 NaN MAOA;MAOB
vemurafenib Kinase inhibitor No MSN09 Down Serotonin inactivation 0.000438979 2 NaN MAOA;MAOB
vemurafenib Kinase inhibitor No MSN05 Up Sister chromatid attachment to mitotic spindle 0.042414608 13.5 NaN NUF2
vemurafenib Kinase inhibitor No MSN06 Up Sister chromatid attachment to mitotic spindle 0.039304304 13 NaN NUF2
vemurafenib Kinase inhibitor No MSN08 Up Sister chromatid attachment to mitotic spindle 0.043277686 16 NaN NUF2
vemurafenib Kinase inhibitor No MSN09 Up Sister chromatid attachment to mitotic spindle 0.043622809 14 NaN NUF2
vemurafenib Kinase inhibitor No MSN09 Down Sodium transmembrane transport 0.028965755 12 NaN FXYD5;SCN1A;SLC5A1
vemurafenib Kinase inhibitor No MSN09 Up Sphingolipid metabolism 0.01523495 6 NaN CERS4;ST8SIA1;UGCG
vemurafenib Kinase inhibitor No MSN01 Up Thrombospondin receptor signaling 0.002332606 2 NaN THBS2;THBS4
vemurafenib Kinase inhibitor No MSN08 Up Thrombospondin receptor signaling 4.07E-05 1.5 NaN CD47;THBS2;THBS4
vemurafenib Kinase inhibitor No MSN09 Up Thrombospondin receptor signaling 4.17E-05 1 NaN CD47;THBS2;THBS4
vemurafenib Kinase inhibitor No MSN09 Down Tight junction organization 0.033900141 13 NaN CLDN11;CLDN6;MYLK
vemurafenib Kinase inhibitor No MSN01 Down Transmembrane glucose transport 0.003261527 6 NaN SLC2A1;SLC2A3
vemurafenib Kinase inhibitor No MSN09 Down Transsulfuration pathway 0.02099506 10 NaN MAT1A
vemurafenib Kinase inhibitor No MSN01 Up Tropoelastin synthesis 0.0200247 6.5 NaN ELN
vemurafenib Kinase inhibitor No MSN05 Down Tropoelastin synthesis 0.021877205 11 NaN ELN
vemurafenib Kinase inhibitor No MSN01 Up Vasoactive intestinal peptide receptor signaling 0.039650143 13 NaN VIPR2
vemurafenib Kinase inhibitor No MSN05 Up Vasoactive intestinal peptide receptor signaling 0.042414608 13.5 NaN VIPR2
vemurafenib Kinase inhibitor No MSN06 Up Vasoactive intestinal peptide receptor signaling 0.039304304 13 NaN VIPR2
vemurafenib Kinase inhibitor No MSN08 Up Vasoactive intestinal peptide receptor signaling 0.043277686 16 NaN VIPR2
vemurafenib Kinase inhibitor No MSN09 Down Vasoactive intestinal peptide receptor signaling 0.041551141 15 NaN VIPR1
vemurafenib Kinase inhibitor No MSN06 Up Versican receptor signaling 0.039304304 13 NaN VCAN
vemurafenib Kinase inhibitor No MSN06 Up Versican synthesis 0.019848271 8 NaN VCAN
vemurafenib Kinase inhibitor No MSN06 Down Vimentin-like intermediate filament dynamics 0.001884281 4.5 NaN DES;GFAP
vemurafenib Kinase inhibitor No MSN06 Up Water transmembrane transport 0.010149397 6 NaN AQP10;AQP7
vemurafenib Kinase inhibitor No MSN01 Up WNT-Beta-catenin signaling pathway 0.039120547 11 NaN FZD1;SFRP1;SFRP2;WNT3A
vemurafenib Kinase inhibitor No MSN05 Up WNT-Beta-catenin signaling pathway 0.002420842 3 NaN FZD1;FZD2;PAX6;SFRP1;SFRP2;WNT3A
vemurafenib Kinase inhibitor No MSN01 Up Z-disc organization 0.039837635 15 NaN CSRP3;DYSF
vemurafenib Kinase inhibitor No MSN09 Up Z-disc organization 0.047440656 16 NaN CSRP3;DYSF
vemurafenib Kinase inhibitor No MSN05 Down Z-disc organization 0.046759314 14 NaN DES;PDLIM3
vemurafenib Kinase inhibitor No MSN09 Down Z-disc organization 0.043409684 17 NaN DES;PDLIM3
vemurafenib Kinase inhibitor No MSN06 Down Adrenergic receptor signaling 0.02715843 18 NaN ADRB3;GRK5;PDE4D
vemurafenib Kinase inhibitor No MSN01 Up Aggrecan synthesis 0.0200247 6.5 NaN ACAN
vemurafenib Kinase inhibitor No MSN08 Up Aggrecan synthesis 0.021877205 9.5 NaN ACAN
vemurafenib Kinase inhibitor No MSN01 Up Albumin mediated blood protein transport 0.0200247 6.5 NaN ALB
vemurafenib Kinase inhibitor No MSN05 Up Albumin mediated blood protein transport 0.021436133 7.5 NaN ALB
vemurafenib Kinase inhibitor No MSN09 Up Albumin mediated blood protein transport 0.022053634 9.5 NaN ALB
vemurafenib Kinase inhibitor No MSN06 Down Albumin mediated blood protein transport 0.025317572 16.5 NaN ALB
vemurafenib Kinase inhibitor No MSN06 Down Aspartate and arginine metabolism 0.025134697 14.5 NaN ASS1;SLC7A1
vemurafenib Kinase inhibitor No MSN08 Down Aspartate and arginine metabolism 0.022263706 13.5 NaN ASS1;SLC7A1
vemurafenib Kinase inhibitor No MSN05 Up Axonal intermediate filament dynamics 0.008950881 5 NaN NEFL;NES
vemurafenib Kinase inhibitor No MSN06 Up Axonal intermediate filament dynamics 0.007712399 5 NaN NEFM;NES
vemurafenib Kinase inhibitor No MSN08 Up Axonal intermediate filament dynamics 0.009309998 6 NaN NEFH;NES
vemurafenib Kinase inhibitor No MSN09 Up Axonal intermediate filament dynamics 0.009455468 4.5 NaN NEFH;NEFM
vemurafenib Kinase inhibitor No MSN01 Up Biglycan synthesis 0.0200247 6.5 NaN BGN
vemurafenib Kinase inhibitor No MSN05 Up Biglycan synthesis 0.021436133 7.5 NaN BGN
vemurafenib Kinase inhibitor No MSN06 Up Biglycan synthesis 0.019848271 8 NaN BGN
vemurafenib Kinase inhibitor No MSN08 Up Biglycan synthesis 0.021877205 9.5 NaN BGN
vemurafenib Kinase inhibitor No MSN09 Up Biglycan synthesis 0.022053634 9.5 NaN BGN
vemurafenib Kinase inhibitor No MSN01 Down Calcitonin receptor signaling 0.046898366 17 NaN RAMP1
vemurafenib Kinase inhibitor No MSN06 Up Cardiomyocyte repolarization during action potential and hyperpolarization 0.030506558 11 NaN KCNA1;KCNJ2
vemurafenib Kinase inhibitor No MSN08 Up Cardiomyocyte repolarization during action potential and hyperpolarization 0.03648388 13.5 NaN KCNA1;KCNJ2
vemurafenib Kinase inhibitor No MSN01 Down CCN intercellular signaling protein family receptor signaling 0.005350837 7.5 NaN CTGF;CYR61
vemurafenib Kinase inhibitor No MSN05 Down CCN intercellular signaling protein family receptor signaling 0.004563637 7 NaN CTGF;CYR61
vemurafenib Kinase inhibitor No MSN06 Down CCN intercellular signaling protein family receptor signaling 0.006072761 8 NaN CTGF;CYR61
vemurafenib Kinase inhibitor No MSN08 Down CCN intercellular signaling protein family receptor signaling 0.005350837 7 NaN CTGF;CYR61
vemurafenib Kinase inhibitor No MSN09 Down CCN intercellular signaling protein family receptor signaling 0.004209808 7 NaN CTGF;WISP1
vemurafenib Kinase inhibitor No MSN01 Up CD44-Mediated leukocyte rolling 0.039650143 13 NaN CD44
vemurafenib Kinase inhibitor No MSN06 Down CD44-Mediated leukocyte rolling 0.049996342 20.5 NaN CD44
vemurafenib Kinase inhibitor No MSN05 Up Cellular cholesterol uptake and efflux 0.03055135 10 NaN ABCA1;ABCG1
vemurafenib Kinase inhibitor No MSN06 Up Cellular cholesterol uptake and efflux 0.02648975 10 NaN ABCA1;ABCG1
vemurafenib Kinase inhibitor No MSN08 Up Cellular cholesterol uptake and efflux 0.002514941 3 NaN ABCA1;ABCG1;SCARA3
vemurafenib Kinase inhibitor No MSN01 Down Cholesterol synthesis 4.95E-06 1 NaN FDPS;HMGCR;HMGCS1;MVD;MVK;SQLE
vemurafenib Kinase inhibitor No MSN05 Down Cholesterol synthesis 5.70E-05 2 NaN DHCR7;FDPS;HMGCR;HMGCS1;MVD
vemurafenib Kinase inhibitor No MSN06 Down Cholesterol synthesis 5.81E-15 1 NaN CYP51A1;DHCR24;DHCR7;FDFT1;FDPS;HMGCR;HMGCS1;LSS;MSMO1;MVD;NSDHL;SQLE
vemurafenib Kinase inhibitor No MSN08 Down Cholesterol synthesis 1.52E-13 1 NaN CYP51A1;DHCR7;FDFT1;HMGCR;HMGCS1;LSS;MSMO1;MVD;MVK;NSDHL;SQLE
vemurafenib Kinase inhibitor No MSN09 Down Cholesterol synthesis 4.69E-05 1 NaN CYP51A1;DHCR7;HMGCS1;MVD;MVK
vemurafenib Kinase inhibitor No MSN01 Down Cholesterol-sensitive control of SREBP activation 0.007900936 9 NaN INSIG1;SREBF1
vemurafenib Kinase inhibitor No MSN08 Down Cholesterol-sensitive control of SREBP activation 0.007900936 9 NaN INSIG1;SREBF1
vemurafenib Kinase inhibitor No MSN09 Down Cholesterol-sensitive control of SREBP activation 0.006227501 8.5 NaN INSIG1;SREBF1
vemurafenib Kinase inhibitor No MSN01 Up Collagen fibril organization by fibril-associated bridges 0.005678798 3 NaN COL12A1;COL9A3
vemurafenib Kinase inhibitor No MSN05 Up Collagen fibril organization by fibril-associated bridges 0.006484773 4 NaN COL12A1;COL9A3
vemurafenib Kinase inhibitor No MSN08 Up Collagen fibril organization by fibril-associated bridges 0.006746931 5 NaN COL12A1;COL9A3
vemurafenib Kinase inhibitor No MSN09 Up Collagen fibril organization by fibril-associated bridges 0.006853158 3 NaN COL12A1;COL9A3
vemurafenib Kinase inhibitor No MSN05 Down Collagen fibril organization by fibril-associated bridges 0.006746931 8 NaN COL14A1;COL9A1
vemurafenib Kinase inhibitor No MSN01 Up Decorin synthesis 0.0200247 6.5 NaN DCN
vemurafenib Kinase inhibitor No MSN05 Up Decorin synthesis 0.021436133 7.5 NaN DCN
vemurafenib Kinase inhibitor No MSN09 Up Decorin synthesis 0.022053634 9.5 NaN DCN
vemurafenib Kinase inhibitor No MSN06 Down Decorin synthesis 0.025317572 16.5 NaN DCN
vemurafenib Kinase inhibitor No MSN01 Down Desaturation of fatty acids 0.01088894 10 NaN FADS2;SCD
vemurafenib Kinase inhibitor No MSN05 Down Desaturation of fatty acids 0.009309998 9 NaN FADS2;SCD
vemurafenib Kinase inhibitor No MSN06 Down Epithelial intermediate filament dynamics 0.016169721 10.5 NaN KRT19;KRT4
vemurafenib Kinase inhibitor No MSN08 Down Epithelial intermediate filament dynamics 0.014292788 11.5 NaN KRT19;KRT7
vandetanib Kinase inhibitor Yes MSN09 Down Activin receptor signaling 0.028464226 10 NaN ACVRL1;SMAD9
vandetanib Kinase inhibitor Yes MSN05 Up Albumin mediated blood protein transport 0.02099506 12 NaN ALB
vandetanib Kinase inhibitor Yes MSN08 Up Albumin mediated blood protein transport 0.02099506 10 NaN ALB
vandetanib Kinase inhibitor Yes MSN09 Up Albumin mediated blood protein transport 0.020906845 11.5 NaN ALB
vandetanib Kinase inhibitor Yes MSN05 Up Alternative complement pathway 0.004209808 5.5 NaN C1S;CFH
vandetanib Kinase inhibitor Yes MSN08 Up Alternative complement pathway 0.004209808 4.5 NaN C1S;CFH
vandetanib Kinase inhibitor Yes MSN09 Up Alternative complement pathway 0.004175176 4.5 NaN C1S;CFH
vandetanib Kinase inhibitor Yes MSN05 Down Biglycan synthesis 0.023200423 10 18 Down by cardiotoxic TKIs BGN
vandetanib Kinase inhibitor Yes MSN08 Down Biglycan synthesis 0.022582922 4.5 18 Down by cardiotoxic TKIs BGN
vandetanib Kinase inhibitor Yes MSN09 Down Biglycan synthesis 0.022406493 7.5 18 Down by cardiotoxic TKIs BGN
vandetanib Kinase inhibitor Yes MSN05 Down Cardiomyocyte pacemaker current generation 0.013690263 6 NaN CACNA1G;KCNK2
vandetanib Kinase inhibitor Yes MSN08 Down Cardiomyocyte pacemaker current generation 0.013002108 3 NaN CACNA1G;KCNK2
vandetanib Kinase inhibitor Yes MSN05 Up Cardiomyocyte repolarization during action potential and hyperpolarization 0.002802661 4 NaN KCNA5;KCNIP2;KCNJ2
vandetanib Kinase inhibitor Yes MSN08 Up Cardiomyocyte repolarization during action potential and hyperpolarization 0.002802661 3 NaN KCND2;KCNIP2;KCNJ2
vandetanib Kinase inhibitor Yes MSN09 Up Cardiomyocyte repolarization during action potential and hyperpolarization 0.002769359 3 NaN KCNA5;KCNIP2;KCNJ2
vandetanib Kinase inhibitor Yes MSN05 Up CD44-Mediated leukocyte rolling 0.041551141 18 NaN CD44
vandetanib Kinase inhibitor Yes MSN08 Up CD44-Mediated leukocyte rolling 0.041551141 17 NaN CD44
vandetanib Kinase inhibitor Yes MSN09 Up CD44-Mediated leukocyte rolling 0.041378401 17.5 NaN CD44
vandetanib Kinase inhibitor Yes MSN05 Down Cellular cholesterol uptake and efflux 0.035340255 15 23 Down by cardiotoxic TKIs ABCA1;SCARA3
vandetanib Kinase inhibitor Yes MSN08 Down Cellular cholesterol uptake and efflux 0.002752604 1 23 Down by cardiotoxic TKIs ABCA1;MYLIP;SCARA3
vandetanib Kinase inhibitor Yes MSN05 Down Centrosome separation 0.021340058 7 NaN CDK1;NEK6
vandetanib Kinase inhibitor Yes MSN08 Down Chloride transmembrane transport 0.03363188 7.5 17 Down by cardiotoxic TKIs SLC12A7;SLC26A1
vandetanib Kinase inhibitor Yes MSN05 Up Cholesterol synthesis 0.00070437 2 22 Up by cardiotoxic TKIs HMGCR;HMGCS1;MSMO1;MVD
vandetanib Kinase inhibitor Yes MSN05 Up Classical complement pathway 0.0085983 8 NaN C1R;C1S
vandetanib Kinase inhibitor Yes MSN08 Up Classical complement pathway 0.0085983 6.5 NaN C1R;C1S
vandetanib Kinase inhibitor Yes MSN09 Up Classical complement pathway 0.00852857 7 NaN C1R;C1S
vandetanib Kinase inhibitor Yes MSN05 Up Collagen fibril organization by fibril-associated bridges 0.006227501 7 NaN COL14A1;COL9A1
vandetanib Kinase inhibitor Yes MSN09 Up Collagen fibril organization by fibril-associated bridges 0.006176635 6 NaN COL14A1;COL9A1
vandetanib Kinase inhibitor Yes MSN05 Up Decorin synthesis 0.02099506 12 NaN DCN
vandetanib Kinase inhibitor Yes MSN08 Up Decorin synthesis 0.02099506 10 NaN DCN
vandetanib Kinase inhibitor Yes MSN09 Up Decorin synthesis 0.020906845 11.5 NaN DCN
vandetanib Kinase inhibitor Yes MSN05 Down Eicosanoid metabolism 0.046155652 19 NaN CYP2J2;PTGS2
vandetanib Kinase inhibitor Yes MSN09 Down Eicosanoid metabolism 0.043339696 12 NaN CYP2J2;PTGS2
vandetanib Kinase inhibitor Yes MSN05 Up Endogenous control of complement activity 0.004209808 5.5 NaN CFH;CFI
vandetanib Kinase inhibitor Yes MSN08 Up Endogenous control of complement activity 0.004209808 4.5 NaN CFH;CFI
vandetanib Kinase inhibitor Yes MSN09 Up Endogenous control of complement activity 0.004175176 4.5 NaN CFH;CFI
vandetanib Kinase inhibitor Yes MSN05 Down Mitotic spindle disassembly 0.023200423 10 NaN CDK1
vandetanib Kinase inhibitor Yes MSN09 Down Natriuretic peptide receptor signaling 0.007067944 2.5 NaN NPR1;NPR3
vandetanib Kinase inhibitor Yes MSN05 Down Notch receptor signaling 0.010508893 5 NaN DLK1;JAG1;LFNG
vandetanib Kinase inhibitor Yes MSN09 Down Notch receptor signaling 0.009558809 4 NaN DLK1;JAG1;LFNG
vandetanib Kinase inhibitor Yes MSN05 Up Osteonectin receptor signaling 0.002561319 3 NaN SMOC2;SPARC
vandetanib Kinase inhibitor Yes MSN08 Up Osteonectin receptor signaling 0.002561319 1.5 NaN SMOC2;SPOCK1
vandetanib Kinase inhibitor Yes MSN09 Up Osteonectin receptor signaling 0.002540098 2 NaN SMOC2;SPARC
vandetanib Kinase inhibitor Yes MSN05 Up Osteopontin receptor signaling 0.02099506 12 NaN SPP1
vandetanib Kinase inhibitor Yes MSN08 Up Osteopontin receptor signaling 0.02099506 10 NaN SPP1
vandetanib Kinase inhibitor Yes MSN09 Up Osteopontin receptor signaling 0.020906845 11.5 NaN SPP1
vandetanib Kinase inhibitor Yes MSN05 Down Perlecan synthesis 0.023200423 10 NaN HSPG2
vandetanib Kinase inhibitor Yes MSN05 Down Platelet-derived growth factor receptor signaling 0.025687982 13 14 Down by cardiotoxic TKIs PDGFD;PDGFRB
vandetanib Kinase inhibitor Yes MSN09 Down Platelet-derived growth factor receptor signaling 0.02407108 9 14 Down by cardiotoxic TKIs PDGFD;PDGFRB
vandetanib Kinase inhibitor Yes MSN09 Up Progesterone receptor signaling 0.020906845 11.5 NaN PGR
vandetanib Kinase inhibitor Yes MSN05 Down Prostacycline receptor signaling 0.045864587 17 NaN PTGIR
vandetanib Kinase inhibitor Yes MSN08 Down Prostacycline receptor signaling 0.044657802 11.5 NaN PTGIR
vandetanib Kinase inhibitor Yes MSN09 Down Prostacycline receptor signaling 0.044312867 14 NaN PTGIR
vandetanib Kinase inhibitor Yes MSN05 Down Prostaglandin PGF2 alpha receptor signaling 0.045864587 17 NaN PTGFR
vandetanib Kinase inhibitor Yes MSN08 Down Prostaglandin PGF2 alpha receptor signaling 0.044657802 11.5 NaN PTGFR
vandetanib Kinase inhibitor Yes MSN09 Down Prostaglandin PGF2 alpha receptor signaling 0.044312867 14 NaN PTGFR
vandetanib Kinase inhibitor Yes MSN08 Up Regulation of coagulation cascade by protein C 0.002561319 1.5 NaN PROS1;THBD
vandetanib Kinase inhibitor Yes MSN09 Up Restriction point 0.017535602 9 3 Up by cardiotoxic TKIs CDKN1A;E2F1
vandetanib Kinase inhibitor Yes MSN08 Up Retinol metabolism 0.029399062 13.5 NaN ALDH1A1;ALDH1A3
vandetanib Kinase inhibitor Yes MSN05 Down Retinol metabolism 0.00297168 1 NaN DHRS3;RLBP1;STRA6
vandetanib Kinase inhibitor Yes MSN08 Down Retinol metabolism 0.03363188 7.5 NaN DHRS3;RLBP1
vandetanib Kinase inhibitor Yes MSN09 Down Retinol metabolism 0.033150099 11 NaN DHRS3;RLBP1
vandetanib Kinase inhibitor Yes MSN05 Down Roundabout signaling 0.010426243 4 NaN ROBO1;ROBO2
vandetanib Kinase inhibitor Yes MSN05 Up Serine and glycine metabolism 0.021308064 14 19 Up by cardiotoxic TKIs PSAT1;SLC1A5
vandetanib Kinase inhibitor Yes MSN08 Up Serine and glycine metabolism 0.021308064 12 19 Up by cardiotoxic TKIs PSAT1;SLC1A5
vandetanib Kinase inhibitor Yes MSN05 Up Serotonin inactivation 0.041551141 18 NaN MAOA
vandetanib Kinase inhibitor Yes MSN08 Up Serotonin inactivation 0.041551141 17 NaN MAOA
vandetanib Kinase inhibitor Yes MSN09 Up Serotonin inactivation 0.041378401 17.5 NaN MAOA
vandetanib Kinase inhibitor Yes MSN09 Up Sodium transmembrane transport 0.028654752 15 NaN ATP1A2;SLC38A2;SLC5A1
vandetanib Kinase inhibitor Yes MSN08 Up Thin myofilament organization 0.0085983 6.5 NaN ACTA1;LMOD3
vandetanib Kinase inhibitor Yes MSN05 Down Thrombospondin receptor signaling 0.00311962 2 NaN THBS2;THBS4
vandetanib Kinase inhibitor Yes MSN08 Down Thrombospondin receptor signaling 0.002957925 2 NaN THBS2;THBS4
vandetanib Kinase inhibitor Yes MSN05 Down Tropoelastin synthesis 0.023200423 10 NaN ELN
vandetanib Kinase inhibitor Yes MSN08 Down Tropoelastin synthesis 0.022582922 4.5 NaN ELN
vandetanib Kinase inhibitor Yes MSN09 Down Tropoelastin synthesis 0.022406493 7.5 NaN ELN
vandetanib Kinase inhibitor Yes MSN05 Up Vasoactive intestinal peptide receptor signaling 0.041551141 18 NaN VIPR2
vandetanib Kinase inhibitor Yes MSN08 Up Vasoactive intestinal peptide receptor signaling 0.041551141 17 NaN VIPR2
vandetanib Kinase inhibitor Yes MSN09 Up Vasoactive intestinal peptide receptor signaling 0.041378401 17.5 NaN VIPR2
vandetanib Kinase inhibitor Yes MSN09 Down ER unfolded protein response pathway 0.012808436 5.5 NaN HERPUD1;PPP1R15A
vandetanib Kinase inhibitor Yes MSN05 Up Extracellular matrix breakdown by matrix metalloproteases 0.014337343 10 NaN MMP1;MMP2
vandetanib Kinase inhibitor Yes MSN08 Up Extracellular matrix breakdown by matrix metalloproteases 0.014337343 8 NaN MMP1;MMP2
vandetanib Kinase inhibitor Yes MSN09 Up Extracellular matrix breakdown by matrix metalloproteases 0.014222736 8 NaN MMP1;MMP2
vandetanib Kinase inhibitor Yes MSN05 Up Fibrillar collagen core structure organization 3.60E-05 1 NaN COL11A1;COL1A1;COL1A2;COL3A1
vandetanib Kinase inhibitor Yes MSN09 Up Fibrillar collagen core structure organization 8.86E-07 1 NaN COL11A1;COL1A1;COL1A2;COL2A1;COL3A1
vandetanib Kinase inhibitor Yes MSN09 Down Fibronectin synthesis and extracellular assembly 0.004782464 1 NaN FN1;ITGB3
vandetanib Kinase inhibitor Yes MSN05 Down Fibulin receptor signaling 0.045864587 17 NaN FBLN1
vandetanib Kinase inhibitor Yes MSN09 Down Fibulin receptor signaling 0.044312867 14 NaN FBLN1
vandetanib Kinase inhibitor Yes MSN05 Up G2 M transition checkpoint 0.02522021 15 NaN CCNG1;WEE1
vandetanib Kinase inhibitor Yes MSN09 Up G2 M transition checkpoint 0.025022959 14 NaN CCNG1;WEE1
vandetanib Kinase inhibitor Yes MSN05 Down GABA metabolism 0.007562538 3 NaN ABAT;SLC6A1
vandetanib Kinase inhibitor Yes MSN09 Down GABA metabolism 0.007067944 2.5 NaN ABAT;SLC6A1
vandetanib Kinase inhibitor Yes MSN08 Down Gap junction organization 0.038662978 9 24 Down by cardiotoxic TKIs GJA5;GJD2
vandetanib Kinase inhibitor Yes MSN08 Up Glutamate and glutamine metabolism 0.029399062 13.5 NaN SLC1A5;SLC7A5
vandetanib Kinase inhibitor Yes MSN09 Down Growth differentiation factor receptor signaling 0.012808436 5.5 NaN GDF10;GDF2
vandetanib Kinase inhibitor Yes MSN05 Down Hyaluronan-mediated motility receptor signaling 0.023200423 10 NaN HMMR
vandetanib Kinase inhibitor Yes MSN05 Up Inhibin receptor signaling 0.011306612 9 NaN INHA;INHBA
vandetanib Kinase inhibitor Yes MSN05 Down Inhibition of apoptosis 0.030360474 14 NaN BIRC5;BIRC7
vandetanib Kinase inhibitor Yes MSN08 Down Inhibition of apoptosis 0.028881222 6 NaN BIRC5;BIRC7
vandetanib Kinase inhibitor Yes MSN05 Up JAK-STAT signaling pathway 0.033831795 16 NaN STAT3;STAT4
vandetanib Kinase inhibitor Yes MSN08 Up JAK-STAT signaling pathway 0.033831795 15 NaN STAT3;STAT4
vandetanib Kinase inhibitor Yes MSN08 Down Lipogenesis 0.044657802 11.5 NaN FASN
vandetanib Kinase inhibitor Yes MSN09 Up Methionine cycle 0.041378401 17.5 NaN BHMT
vandetanib Kinase inhibitor Yes MSN08 Down Microfibril scaffold organization 0.044657802 11.5 NaN FBN1
vandetanib Kinase inhibitor Yes MSN09 Down Z-disc organization 0.048814568 16 NaN DES;TCAP
trastuzumab Monoclonal antibody Yes MSN05 Down WNT-Beta-catenin signaling pathway 0.009672366 12 NaN DACT1;FZD7;MSX2;SFRP2;WNT1
trastuzumab Monoclonal antibody Yes MSN09 Down WNT-Beta-catenin signaling pathway 0.038589958 19 NaN DACT1;FZD7;SFRP2;WNT1
trastuzumab Monoclonal antibody Yes MSN01 Up Z-disc organization 0.003569197 6 NaN CSRP3;DYSF;TCAP
trastuzumab Monoclonal antibody Yes MSN02 Up Z-disc organization 0.048814568 20.5 NaN DES;TCAP
trastuzumab Monoclonal antibody Yes MSN09 Up Z-disc organization 0.006383649 1 NaN CSRP3;DES;TCAP
trastuzumab Monoclonal antibody Yes MSN01 Down Mitotic spindle assembly 0.000249918 5 NaN DLGAP5;NUSAP1;TPX2;TTK
trastuzumab Monoclonal antibody Yes MSN02 Down Mitotic spindle assembly 0.032910271 23 NaN NUSAP1;TPX2
trastuzumab Monoclonal antibody Yes MSN01 Down Mitotic spindle disassembly 0.025582216 22 NaN CDK1
trastuzumab Monoclonal antibody Yes MSN02 Down Mitotic spindle disassembly 0.022318278 18.5 NaN CDK1
trastuzumab Monoclonal antibody Yes MSN09 Down Mitotic spindle disassembly 0.019936486 15 NaN CDK1
trastuzumab Monoclonal antibody Yes MSN09 Up Natriuretic peptide receptor signaling 0.008362857 2.5 NaN NPPC;NPR1
trastuzumab Monoclonal antibody Yes MSN02 Down Natriuretic peptide receptor signaling 0.007013957 13 NaN NPPA;NPPB
trastuzumab Monoclonal antibody Yes MSN05 Down Natriuretic peptide receptor signaling 0.005875567 9.5 NaN NPPA;NPPB
trastuzumab Monoclonal antibody Yes MSN09 Down Natriuretic peptide receptor signaling 0.0056301 9.5 NaN NPPA;NPPB
trastuzumab Monoclonal antibody Yes MSN01 Down Osteonectin receptor signaling 0.003782172 14 NaN SPARC;SPOCK1
trastuzumab Monoclonal antibody Yes MSN02 Down Osteonectin receptor signaling 0.002889904 8.5 NaN SPARC;SPOCK1
trastuzumab Monoclonal antibody Yes MSN01 Up Osteopontin receptor signaling 0.019848271 15 NaN SPP1
trastuzumab Monoclonal antibody Yes MSN02 Up Osteopontin receptor signaling 0.022406493 11.5 NaN SPP1
trastuzumab Monoclonal antibody Yes MSN05 Up Osteopontin receptor signaling 0.024170783 8 NaN SPP1
trastuzumab Monoclonal antibody Yes MSN09 Up Osteopontin receptor signaling 0.024435427 8 NaN SPP1
trastuzumab Monoclonal antibody Yes MSN01 Down Platelet-derived growth factor receptor signaling 0.002347329 10.5 14 Down by cardiotoxic TKIs PDGFD;PDGFRA;TNK2
trastuzumab Monoclonal antibody Yes MSN02 Down Platelet-derived growth factor receptor signaling 7.07E-05 2 14 Down by cardiotoxic TKIs FOSL1;PDGFRA;PDGFRB;TNK2
trastuzumab Monoclonal antibody Yes MSN05 Down Platelet-derived growth factor receptor signaling 0.001221097 5 14 Down by cardiotoxic TKIs PDGFRA;PDGFRB;TNK2
trastuzumab Monoclonal antibody Yes MSN09 Down Platelet-derived growth factor receptor signaling 0.001146233 3.5 14 Down by cardiotoxic TKIs PDGFRA;PDGFRB;TNK2
trastuzumab Monoclonal antibody Yes MSN01 Up Potassium transmembrane transport 0.011481125 10 7 Up by cardiotoxic TKIs ABCC9;ATP1A2;KCNE4
trastuzumab Monoclonal antibody Yes MSN02 Up Potassium transmembrane transport 0.015893011 6.5 7 Up by cardiotoxic TKIs ATP1A2;KCNE4;KCNQ1
trastuzumab Monoclonal antibody Yes MSN02 Up Protein polyubiquitination 0.048814568 20.5 NaN ISG15;UCHL1
trastuzumab Monoclonal antibody Yes MSN01 Up Removal of caspase inhibition 0.039304304 21 NaN XAF1
trastuzumab Monoclonal antibody Yes MSN02 Up Removal of caspase inhibition 0.044312867 18 NaN XAF1
trastuzumab Monoclonal antibody Yes MSN05 Up Removal of caspase inhibition 0.047759421 12 NaN XAF1
trastuzumab Monoclonal antibody Yes MSN09 Up Removal of caspase inhibition 0.048275867 14 NaN XAF1
trastuzumab Monoclonal antibody Yes MSN02 Up Retinol metabolism 0.033150099 15 NaN ALDH1A1;ALDH1A3
trastuzumab Monoclonal antibody Yes MSN05 Up Retinol metabolism 0.00020098 1 NaN ALDH1A2;ALDH1A3;DHRS3;RBP1
trastuzumab Monoclonal antibody Yes MSN09 Up Retinol metabolism 0.038858469 11 NaN ALDH1A2;ALDH1A3
trastuzumab Monoclonal antibody Yes MSN02 Up Semaphorin signaling 0.039932176 16 NaN NRP2;PLXND1;RND1
trastuzumab Monoclonal antibody Yes MSN05 Up Semaphorin signaling 0.04819315 14 NaN PLXND1;RND1;SEMA6B
trastuzumab Monoclonal antibody Yes MSN01 Down Serine and glycine metabolism 0.002347329 10.5 NaN PHGDH;PSAT1;SHMT2
trastuzumab Monoclonal antibody Yes MSN02 Down Serine and glycine metabolism 0.001587334 7 NaN PHGDH;PSAT1;SHMT2
trastuzumab Monoclonal antibody Yes MSN05 Down Serine and glycine metabolism 0.020145007 14 NaN PHGDH;SHMT2
trastuzumab Monoclonal antibody Yes MSN09 Down Serine and glycine metabolism 0.001146233 3.5 NaN PHGDH;PSAT1;SHMT2
trastuzumab Monoclonal antibody Yes MSN01 Down Serotonin inactivation 0.000652251 7 NaN MAOA;MAOB
trastuzumab Monoclonal antibody Yes MSN01 Down Sister chromatid segregation 0.009139439 17.5 NaN PTTG1;TOP2A
trastuzumab Monoclonal antibody Yes MSN02 Down Sister chromatid segregation 0.007013957 13 NaN ESPL1;TOP2A
trastuzumab Monoclonal antibody Yes MSN05 Down Sister chromatid segregation 0.005875567 9.5 NaN ESPL1;TOP2A
trastuzumab Monoclonal antibody Yes MSN09 Down Sister chromatid segregation 0.0056301 9.5 NaN ESPL1;TOP2A
trastuzumab Monoclonal antibody Yes MSN01 Up Thick myofilament organization 0.001161278 3 NaN MYBPC3;TTN
trastuzumab Monoclonal antibody Yes MSN02 Up Thick myofilament organization 0.001478116 1 NaN MYBPC3;MYH7
trastuzumab Monoclonal antibody Yes MSN01 Up Thin myofilament organization 0.000254603 2 NaN ACTA1;LMOD3;TNNI3
trastuzumab Monoclonal antibody Yes MSN05 Up Thin myofilament organization 0.000454886 2 NaN ACTA1;LMOD3;TNNI3
trastuzumab Monoclonal antibody Yes MSN09 Up Thin myofilament organization 0.011520133 4 NaN ACTA1;LMOD3
trastuzumab Monoclonal antibody Yes MSN01 Down Thrombospondin receptor signaling 0.003782172 14 NaN THBS1;THBS4
trastuzumab Monoclonal antibody Yes MSN02 Down Thrombospondin receptor signaling 0.002889904 8.5 NaN THBS1;THBS4
trastuzumab Monoclonal antibody Yes MSN05 Down Thrombospondin receptor signaling 3.29E-05 2 NaN THBS1;THBS2;THBS4
trastuzumab Monoclonal antibody Yes MSN09 Down Thrombospondin receptor signaling 0.00231233 6 NaN THBS1;THBS4
trastuzumab Monoclonal antibody Yes MSN01 Down Tropoelastin synthesis 0.025582216 22 NaN ELN
trastuzumab Monoclonal antibody Yes MSN02 Down Tropoelastin synthesis 0.022318278 18.5 NaN ELN
trastuzumab Monoclonal antibody Yes MSN05 Down Tropoelastin synthesis 0.020377558 16.5 NaN ELN
trastuzumab Monoclonal antibody Yes MSN09 Down Tropoelastin synthesis 0.019936486 15 NaN ELN
trastuzumab Monoclonal antibody Yes MSN02 Down Versican receptor signaling 0.044140376 26 NaN VCAN
trastuzumab Monoclonal antibody Yes MSN05 Down Versican receptor signaling 0.040341633 21 NaN VCAN
trastuzumab Monoclonal antibody Yes MSN09 Down Versican receptor signaling 0.039477231 21.5 NaN VCAN
trastuzumab Monoclonal antibody Yes MSN02 Down Versican synthesis 0.022318278 18.5 NaN VCAN
trastuzumab Monoclonal antibody Yes MSN05 Down Versican synthesis 0.020377558 16.5 NaN VCAN
trastuzumab Monoclonal antibody Yes MSN09 Down Versican synthesis 0.019936486 15 NaN VCAN
trastuzumab Monoclonal antibody Yes MSN09 Up Water transmembrane transport 0.015114208 5.5 NaN AQP1;AQP3
trastuzumab Monoclonal antibody Yes MSN01 Up WNT-Beta-catenin signaling pathway 0.03806357 20 NaN CTHRC1;SFRP4;SFRP5;WNT2
trastuzumab Monoclonal antibody Yes MSN02 Up WNT-Beta-catenin signaling pathway 0.014145821 5 NaN CTHRC1;FZD2;SFRP4;SFRP5;WNT2
trastuzumab Monoclonal antibody Yes MSN01 Up Aggrecan synthesis 0.019848271 15 NaN ACAN
trastuzumab Monoclonal antibody Yes MSN02 Up Aggrecan synthesis 0.022406493 11.5 NaN ACAN
trastuzumab Monoclonal antibody Yes MSN09 Up Aggrecan synthesis 0.024435427 8 NaN ACAN
trastuzumab Monoclonal antibody Yes MSN02 Up Albumin mediated blood protein transport 0.022406493 11.5 NaN ALB
trastuzumab Monoclonal antibody Yes MSN05 Up Albumin mediated blood protein transport 0.024170783 8 NaN ALB
trastuzumab Monoclonal antibody Yes MSN09 Up Albumin mediated blood protein transport 0.024435427 8 NaN ALB
trastuzumab Monoclonal antibody Yes MSN01 Up Antigen presentation via MHC class I molecules 0.015890842 12.5 NaN HLA-A;HLA-C
trastuzumab Monoclonal antibody Yes MSN01 Down Aspartate and arginine metabolism 0.025627571 24 NaN ARG2;SLC7A1
trastuzumab Monoclonal antibody Yes MSN02 Down Aspartate and arginine metabolism 0.019838394 15 NaN ARG2;SLC7A1
trastuzumab Monoclonal antibody Yes MSN02 Down Biglycan synthesis 0.022318278 18.5 18 Down by cardiotoxic TKIs BGN
trastuzumab Monoclonal antibody Yes MSN05 Down Biglycan synthesis 0.020377558 16.5 18 Down by cardiotoxic TKIs BGN
trastuzumab Monoclonal antibody Yes MSN09 Down Biglycan synthesis 0.019936486 15 18 Down by cardiotoxic TKIs BGN
trastuzumab Monoclonal antibody Yes MSN01 Up Cardiomyocyte depolarization during action potential 0.019848271 15 NaN SCN5A
trastuzumab Monoclonal antibody Yes MSN02 Up Cardiomyocyte depolarization during action potential 0.022406493 11.5 NaN SCN5A
trastuzumab Monoclonal antibody Yes MSN05 Up Cardiomyocyte depolarization during action potential 0.024170783 8 NaN SCN5A
trastuzumab Monoclonal antibody Yes MSN01 Up Cardiomyocyte pacemaker current generation 0.010149397 8.5 NaN CACNA1G;HCN4
trastuzumab Monoclonal antibody Yes MSN01 Up Cardiomyocyte repolarization during action potential and hyperpolarization 0.030506558 19 NaN KCNA1;KCNQ5
trastuzumab Monoclonal antibody Yes MSN02 Down CCN intercellular signaling protein family receptor signaling 0.004745654 10.5 NaN CTGF;CYR61
trastuzumab Monoclonal antibody Yes MSN05 Down CCN intercellular signaling protein family receptor signaling 0.003970259 6.5 NaN CTGF;CYR61
trastuzumab Monoclonal antibody Yes MSN09 Down CCN intercellular signaling protein family receptor signaling 0.003803269 7 NaN CTGF;CYR61
trastuzumab Monoclonal antibody Yes MSN02 Down CD44-Mediated leukocyte rolling 0.044140376 26 NaN CD44
trastuzumab Monoclonal antibody Yes MSN09 Down CD44-Mediated leukocyte rolling 0.039477231 21.5 NaN CD44
trastuzumab Monoclonal antibody Yes MSN01 Up Cellular cholesterol uptake and efflux 0.02648975 18 NaN ABCA1;SCARA3
trastuzumab Monoclonal antibody Yes MSN01 Down Centrosome separation 7.80E-05 3 NaN CCNB1;CDK1;KIF11;SPAG5
trastuzumab Monoclonal antibody Yes MSN02 Down Centrosome separation 0.001173699 5 NaN CCNB1;CDK1;ESPL1
trastuzumab Monoclonal antibody Yes MSN09 Down Centrosome separation 0.016025171 12 NaN CDK1;ESPL1
trastuzumab Monoclonal antibody Yes MSN09 Up Chaperone-mediated autophagy 0.048275867 14 NaN HSPA8
trastuzumab Monoclonal antibody Yes MSN01 Down Cholesterol synthesis 3.48E-13 1 NaN CYP51A1;DHCR24;DHCR7;FDFT1;HMGCR;HMGCS1;MSMO1;MVD;MVK;SC5D;SQLE
trastuzumab Monoclonal antibody Yes MSN05 Down Cholesterol synthesis 0.000629594 3 NaN DHCR24;DHCR7;MSMO1;MVK
trastuzumab Monoclonal antibody Yes MSN01 Down Cholesterol-sensitive control of SREBP activation 0.009139439 17.5 NaN INSIG1;SREBF1
trastuzumab Monoclonal antibody Yes MSN05 Down Cholesterol-sensitive control of SREBP activation 0.005875567 9.5 NaN INSIG1;SREBF1
trastuzumab Monoclonal antibody Yes MSN09 Down Cholesterol-sensitive control of SREBP activation 0.0056301 9.5 NaN INSIG1;SREBF1
trastuzumab Monoclonal antibody Yes MSN02 Up Classical complement pathway 0.00974952 3 NaN C1QB;C1R
trastuzumab Monoclonal antibody Yes MSN01 Up Collagen fiber crosslinking 0.003770283 7 NaN LOX;PXDN
trastuzumab Monoclonal antibody Yes MSN05 Up Collagen fiber crosslinking 0.005547025 3 NaN LOX;PXDN
trastuzumab Monoclonal antibody Yes MSN01 Up Collagen fibril organization by fibril-associated bridges 0.000147651 1 NaN COL12A1;COL14A1;COL9A2
trastuzumab Monoclonal antibody Yes MSN02 Up Collagen fibril organization by fibril-associated bridges 0.007067944 2 NaN COL14A1;COL9A2
trastuzumab Monoclonal antibody Yes MSN09 Up Collagen fibril organization by fibril-associated bridges 0.008362857 2.5 NaN COL14A1;COL9A2
trastuzumab Monoclonal antibody Yes MSN05 Up Connection of muscle sarcomere to plasma membrane 0.023046241 5.5 NaN DES;TLN2
trastuzumab Monoclonal antibody Yes MSN01 Down Contractile ring constriction 0.000159506 4 NaN ANLN;ECT2;MYLK
trastuzumab Monoclonal antibody Yes MSN02 Down Contractile ring constriction 0.004745654 10.5 NaN ECT2;MYLK
trastuzumab Monoclonal antibody Yes MSN05 Down Contractile ring constriction 0.003970259 6.5 NaN ANLN;MYLK
trastuzumab Monoclonal antibody Yes MSN01 Down Decorin synthesis 0.025582216 22 NaN DCN
trastuzumab Monoclonal antibody Yes MSN02 Down Decorin synthesis 0.022318278 18.5 NaN DCN
trastuzumab Monoclonal antibody Yes MSN05 Down Decorin synthesis 0.020377558 16.5 NaN DCN
trastuzumab Monoclonal antibody Yes MSN09 Down Decorin synthesis 0.019936486 15 NaN DCN
trastuzumab Monoclonal antibody Yes MSN01 Down Desaturation of fatty acids 0.012580282 19 NaN FADS2;SCD
trastuzumab Monoclonal antibody Yes MSN05 Up Eicosanoid metabolism 0.049688981 15 NaN CYP2J2;PTGS1
trastuzumab Monoclonal antibody Yes MSN02 Up Epithelial intermediate filament dynamics 0.012808436 4 NaN KRT7;TCHH
trastuzumab Monoclonal antibody Yes MSN09 Up Epithelial intermediate filament dynamics 0.015114208 5.5 NaN KRT7;KRT8
trastuzumab Monoclonal antibody Yes MSN01 Down Equatorial RhoA activation 0.003782172 14 NaN ECT2;KIF23
trastuzumab Monoclonal antibody Yes MSN01 Down ER unfolded protein response pathway 0.00084348 8 NaN ATF4;DDIT3;HERPUD1
trastuzumab Monoclonal antibody Yes MSN01 Down Eukaryotic kinetochore dynamics 0.000368695 6 NaN BUB1;CENPE;CENPF;NDC80;TTK;ZWINT
trastuzumab Monoclonal antibody Yes MSN02 Up Extracellular matrix breakdown and membrane shedding by adamalysins 0.015893011 6.5 NaN ADAM33;ADAMTS2;ADAMTS8
trastuzumab Monoclonal antibody Yes MSN05 Up Extracellular matrix breakdown and membrane shedding by adamalysins 0.019424314 4 NaN ADAM33;ADAMTS2;ADAMTS8
trastuzumab Monoclonal antibody Yes MSN02 Up Extracellular matrix breakdown by cathepsins 0.019986419 8.5 NaN CTSH;CTSV
trastuzumab Monoclonal antibody Yes MSN05 Up Extracellular matrix breakdown by cathepsins 0.023046241 5.5 NaN CTSH;CTSV
trastuzumab Monoclonal antibody Yes MSN02 Down Extracellular matrix breakdown by matrix metalloproteases 0.000835321 4 NaN MMP12;MMP2;MMP3
trastuzumab Monoclonal antibody Yes MSN01 Up Fibrillar collagen core structure organization 0.015890842 12.5 NaN COL11A1;COL2A1
trastuzumab Monoclonal antibody Yes MSN02 Up Fibrillar collagen core structure organization 0.019986419 8.5 NaN COL11A1;COL2A1
trastuzumab Monoclonal antibody Yes MSN01 Down Fibrillar collagen core structure organization 2.40E-06 2 NaN COL11A2;COL1A1;COL1A2;COL3A1;COL5A2
trastuzumab Monoclonal antibody Yes MSN02 Down Fibrillar collagen core structure organization 4.58E-05 1 NaN COL1A1;COL1A2;COL3A1;COL5A2
trastuzumab Monoclonal antibody Yes MSN05 Down Fibrillar collagen core structure organization 0.000901583 4 NaN COL1A1;COL1A2;COL3A1
trastuzumab Monoclonal antibody Yes MSN09 Down Fibrillar collagen core structure organization 0.000846027 1 NaN COL1A1;COL1A2;COL3A1
trastuzumab Monoclonal antibody Yes MSN01 Down G2 M transition checkpoint 0.036346966 25.5 NaN CCNB1;CDK1
trastuzumab Monoclonal antibody Yes MSN02 Down G2 M transition checkpoint 0.028256676 22 NaN CCNB1;CDK1
trastuzumab Monoclonal antibody Yes MSN02 Down GABA metabolism 0.007013957 13 NaN ABAT;SLC6A1
trastuzumab Monoclonal antibody Yes MSN05 Down GABA metabolism 0.005875567 9.5 NaN ABAT;SLC6A1
trastuzumab Monoclonal antibody Yes MSN09 Down GABA metabolism 0.0056301 9.5 NaN ABAT;SLC6A1
trastuzumab Monoclonal antibody Yes MSN09 Up Gap junction organization 0.044617901 12 NaN GJA5;GJB2
trastuzumab Monoclonal antibody Yes MSN01 Down Glycolysis and Gluconeogenesis 0.002529748 12 NaN ENO1;HK2;LDHA;PCK2
trastuzumab Monoclonal antibody Yes MSN02 Down Glycolysis and Gluconeogenesis 0.000128846 3 NaN ENO1;HK2;LDHA;PCK2;PFKFB3
trastuzumab Monoclonal antibody Yes MSN05 Down Glycolysis and Gluconeogenesis 0.010947197 13 NaN ENO1;HK2;LDHA
trastuzumab Monoclonal antibody Yes MSN09 Down Glycolysis and Gluconeogenesis 0.001011093 2 NaN ENO1;HK2;LDHA;PFKFB4
trastuzumab Monoclonal antibody Yes MSN02 Up Granulocyte macrophage colony-stimulating factor receptor signaling 0.044312867 18 NaN JAK2
trastuzumab Monoclonal antibody Yes MSN05 Up Granulocyte macrophage colony-stimulating factor receptor signaling 0.047759421 12 NaN JAK2
trastuzumab Monoclonal antibody Yes MSN09 Up Granulocyte macrophage colony-stimulating factor receptor signaling 0.048275867 14 NaN JAK2
trastuzumab Monoclonal antibody Yes MSN01 Up Granulocyte-colony stimulating factor receptor signaling 0.012879711 11 16 Up by cardiotoxic TKIs SOCS3;STAT3
trastuzumab Monoclonal antibody Yes MSN01 Up Growth differentiation factor receptor signaling 0.010149397 8.5 NaN GDF11;GDF6
trastuzumab Monoclonal antibody Yes MSN01 Down Growth differentiation factor receptor signaling 0.016492549 20 NaN GDF15;GDF2
trastuzumab Monoclonal antibody Yes MSN02 Down Hyaluronan-mediated motility receptor signaling 0.022318278 18.5 NaN HMMR
trastuzumab Monoclonal antibody Yes MSN02 Down Inhibition of amyloid aggregation, amyloid degradation and uptake 0.001466565 6 NaN A2M;PLAT
trastuzumab Monoclonal antibody Yes MSN05 Down Inhibition of amyloid aggregation, amyloid degradation and uptake 8.35E-06 1 NaN A2M;MME;PLAT
trastuzumab Monoclonal antibody Yes MSN09 Down Inhibition of amyloid aggregation, amyloid degradation and uptake 0.001171577 5 NaN A2M;PLAT
trastuzumab Monoclonal antibody Yes MSN01 Up Inhibition of apoptosis 0.022707438 17 NaN IFI6;XAF1
trastuzumab Monoclonal antibody Yes MSN02 Up Inhibition of apoptosis 0.028464226 14 NaN IFI6;XAF1
trastuzumab Monoclonal antibody Yes MSN05 Up Inhibition of apoptosis 0.032746265 10 NaN IFI6;XAF1
trastuzumab Monoclonal antibody Yes MSN09 Up Inhibition of apoptosis 0.033409737 10 NaN IFI6;XAF1
trastuzumab Monoclonal antibody Yes MSN01 Down Inhibition of apoptosis 0.036346966 25.5 NaN BIRC3;BIRC5
trastuzumab Monoclonal antibody Yes MSN02 Down Insulin receptor signaling 0.043031062 24 NaN IRS1;IRS2
trastuzumab Monoclonal antibody Yes MSN05 Down Insulin receptor signaling 0.036462821 19 NaN IRS1;IRS2
trastuzumab Monoclonal antibody Yes MSN09 Down Insulin receptor signaling 0.035030785 18 NaN IRS1;IRS2
trastuzumab Monoclonal antibody Yes MSN01 Up JAK-STAT signaling pathway 0.002388906 5 NaN SOCS3;STAT3;STAT4
trastuzumab Monoclonal antibody Yes MSN01 Up Leptin receptor signaling 0.00229214 4 5 Up by cardiotoxic TKIs SOCS3;STAT3
trastuzumab Monoclonal antibody Yes MSN05 Down Lipogenesis 0.040341633 21 NaN FASN
trastuzumab Monoclonal antibody Yes MSN09 Down Lipogenesis 0.039477231 21.5 NaN FASN
trastuzumab Monoclonal antibody Yes MSN01 Down Metaphase to anaphase checkpoint 0.0016025 9 NaN BUB1;CCNB2;CENPE;PTTG1;TTK
trastuzumab Monoclonal antibody Yes MSN02 Up Methionine cycle 0.044312867 18 NaN BHMT
trastuzumab Monoclonal antibody Yes MSN05 Up Methionine cycle 0.047759421 12 NaN BHMT
trastuzumab Monoclonal antibody Yes MSN02 Down Microfibril scaffold organization 0.044140376 26 NaN FBN1
trastuzumab Monoclonal antibody Yes MSN05 Down Microfibril scaffold organization 0.040341633 21 NaN FBN1
trastuzumab Monoclonal antibody Yes MSN09 Down Microfibril scaffold organization 0.039477231 21.5 NaN FBN1
trastuzumab Monoclonal antibody Yes MSN01 Down Mitotic H3 phosphorylation and dephosphorylation 0.006197282 16 NaN AURKB;CCNA2
trametinib Kinase inhibitor Yes MSN01 Down Eukaryotic kinetochore dynamics 3.42E-07 2 NaN BUB1;CENPE;CENPF;MAD2L1;NDC80;NUF2;SPC24;TTK;ZWINT
trametinib Kinase inhibitor Yes MSN05 Down Eukaryotic kinetochore dynamics 2.29E-08 2 NaN BUB1;CENPE;CENPF;CENPU;MAD2L1;NDC80;NUF2;SKA3;SPC24;TTK;ZWINT
trametinib Kinase inhibitor Yes MSN08 Down Eukaryotic kinetochore dynamics 1.70E-12 1 NaN BUB1;CENPE;CENPF;CENPI;CENPU;KIF15;KNSTRN;MAD2L1;NDC80;NUF2;SKA3;SPC24;TTK;ZWINT
trametinib Kinase inhibitor Yes MSN09 Down Eukaryotic kinetochore dynamics 1.30E-06 2 NaN BUB1;CENPE;CENPF;CENPU;NDC80;NUF2;SPC24;TTK;ZWINT
trametinib Kinase inhibitor Yes MSN05 Up Extracellular matrix breakdown and membrane shedding by adamalysins 0.041630095 8.5 NaN ADAM33;ADAMTS5
trametinib Kinase inhibitor Yes MSN09 Up Extracellular matrix breakdown and membrane shedding by adamalysins 0.007238399 2.5 NaN ADAMTS1;ADAMTS5;ADAMTS6
trametinib Kinase inhibitor Yes MSN01 Down Extracellular matrix breakdown and membrane shedding by adamalysins 0.022338334 22 NaN ADAMTS1;ADAMTS12;ADAMTS6
trametinib Kinase inhibitor Yes MSN05 Down Extracellular matrix breakdown by heparanases and sulfatases 0.006199885 15.5 NaN SULF1;SULF2
trametinib Kinase inhibitor Yes MSN08 Down Extracellular matrix breakdown by heparanases and sulfatases 0.005110927 18.5 NaN SULF1;SULF2
trametinib Kinase inhibitor Yes MSN09 Down Extracellular matrix breakdown by heparanases and sulfatases 0.005140644 15.5 NaN SULF1;SULF2
trametinib Kinase inhibitor Yes MSN01 Down Extracellular matrix breakdown by matrix metalloproteases 4.71E-05 5 NaN MMP1;MMP12;MMP2;MMP3
trametinib Kinase inhibitor Yes MSN01 Down Fanconi anemia interstrand cross-link repair pathway 0.027648786 29 NaN BRIP1;FANCD2;FANCI
trametinib Kinase inhibitor Yes MSN05 Down Fanconi anemia interstrand cross-link repair pathway 0.009718089 19 NaN FANCA;FANCD2;FANCI;UBE2T
trametinib Kinase inhibitor Yes MSN08 Down Fanconi anemia interstrand cross-link repair pathway 0.000897935 13 NaN BRIP1;FANCA;FANCD2;FANCI;UBE2T
trametinib Kinase inhibitor Yes MSN09 Down Fanconi anemia interstrand cross-link repair pathway 0.006979217 17 NaN FANCA;FANCD2;FANCI;UBE2T
trametinib Kinase inhibitor Yes MSN01 Up Fibrillar collagen core structure organization 0.000912967 3 NaN COL1A1;COL1A2;COL3A1
trametinib Kinase inhibitor Yes MSN05 Up Fibrillar collagen core structure organization 0.007681705 1 NaN COL1A2;COL3A1
trametinib Kinase inhibitor Yes MSN08 Up Fibrillar collagen core structure organization 0.000471631 1 NaN COL11A1;COL1A1;COL5A1
trametinib Kinase inhibitor Yes MSN09 Up Fibrillar collagen core structure organization 1.48E-05 1 NaN COL1A1;COL1A2;COL3A1;COL5A1
trametinib Kinase inhibitor Yes MSN01 Down Fibrillar collagen core structure organization 0.025462828 23 NaN COL2A1;COL5A2
trametinib Kinase inhibitor Yes MSN01 Down G2 M transition checkpoint 0.003040976 11.5 NaN CCNB1;CDC25C;CDK1
trametinib Kinase inhibitor Yes MSN05 Down G2 M transition checkpoint 0.006230507 17.5 NaN CCNB1;CDC25C;CDK1
trametinib Kinase inhibitor Yes MSN08 Down G2 M transition checkpoint 0.004730779 16.5 NaN CCNB1;CDC25C;CDK1
trametinib Kinase inhibitor Yes MSN09 Down G2 M transition checkpoint 0.004770148 13.5 NaN CCNB1;CDC25C;CDK1
trametinib Kinase inhibitor Yes MSN01 Down GABA metabolism 0.009078567 18.5 NaN ABAT;SLC6A1
trametinib Kinase inhibitor Yes MSN01 Up Glutamate and glutamine metabolism 0.028040621 9 NaN SLC1A5;SLC7A5
trametinib Kinase inhibitor Yes MSN01 Up Glycolysis and Gluconeogenesis 0.011076009 7 NaN HK2;LDHA;PCK2
trametinib Kinase inhibitor Yes MSN01 Up Granulocyte macrophage colony-stimulating factor receptor signaling 0.040514466 10.5 NaN JAK2
trametinib Kinase inhibitor Yes MSN09 Up Heme degradation to bilirubin 0.049448514 13 NaN HMOX1
trametinib Kinase inhibitor Yes MSN05 Up Hemoglobin and myoglobin synthesis 0.040207462 6.5 NaN MB
trametinib Kinase inhibitor Yes MSN08 Up Hemoglobin and myoglobin synthesis 0.048168598 12.5 NaN MB
trametinib Kinase inhibitor Yes MSN09 Up Hemoglobin and myoglobin synthesis 0.049448514 13 NaN MB
trametinib Kinase inhibitor Yes MSN08 Up Heparin-binding EGF-like growth factor receptor signaling 0.048168598 12.5 NaN HBEGF
trametinib Kinase inhibitor Yes MSN09 Up Hepatocyte growth factor receptor signaling 0.033242055 9 NaN MET
trametinib Kinase inhibitor Yes MSN08 Up HIF-1 receptor signaling pathway 0.008843799 5 NaN CITED2;EGLN3
trametinib Kinase inhibitor Yes MSN09 Up Hyaluronan receptor CD44 signaling 0.049448514 13 NaN CD44
trametinib Kinase inhibitor Yes MSN01 Down Hyaluronan-mediated motility receptor signaling 0.025494001 26 NaN HMMR
trametinib Kinase inhibitor Yes MSN09 Down Hyaluronan-mediated motility receptor signaling 0.029904728 27.5 NaN HMMR
trametinib Kinase inhibitor Yes MSN09 Up Inhibition of amyloid aggregation, amyloid degradation and uptake 0.049448514 13 NaN A2M
trametinib Kinase inhibitor Yes MSN01 Down Integrin-mediated leukocyte rolling 0.012497227 20.5 NaN MAPK14;VCAM1
trametinib Kinase inhibitor Yes MSN01 Up Interferon alpha receptor signaling 0.010765432 5.5 NaN IRF9;STAT1
trametinib Kinase inhibitor Yes MSN01 Down Intracellular bridge assembly 0.001910452 10 NaN INCENP;KIF23
trametinib Kinase inhibitor Yes MSN05 Down Intracellular bridge assembly 0.003168907 14 NaN INCENP;KIF23
trametinib Kinase inhibitor Yes MSN08 Down Intracellular bridge assembly 0.002606858 14 NaN INCENP;KIF23
trametinib Kinase inhibitor Yes MSN09 Down Intracellular bridge assembly 0.002622171 12 NaN INCENP;KIF23
trametinib Kinase inhibitor Yes MSN08 Up Lysine metabolism 0.048168598 12.5 NaN LOX
trametinib Kinase inhibitor Yes MSN01 Down Metaphase to anaphase checkpoint 1.65E-06 3 NaN BUB1;BUB1B;CCNB2;CDC20;CENPE;MAD2L1;PTTG1;TTK
trametinib Kinase inhibitor Yes MSN05 Down Metaphase to anaphase checkpoint 1.09E-05 3 NaN BUB1;BUB1B;CCNB2;CDC20;CENPE;MAD2L1;PTTG1;TTK
trametinib Kinase inhibitor Yes MSN08 Down Metaphase to anaphase checkpoint 5.30E-06 4 NaN BUB1;BUB1B;CCNB2;CDC20;CENPE;MAD2L1;PTTG1;TTK
trametinib Kinase inhibitor Yes MSN09 Down Metaphase to anaphase checkpoint 5.39E-05 4 NaN BUB1;BUB1B;CCNB2;CDC20;CENPE;PTTG1;TTK
trametinib Kinase inhibitor Yes MSN01 Down Mitotic chromosome condensation 0.012497227 20.5 NaN INCENP;SMC4
trametinib Kinase inhibitor Yes MSN05 Down Mitotic chromosome condensation 0.001120646 13 NaN INCENP;NCAPG2;SMC4
trametinib Kinase inhibitor Yes MSN08 Down Mitotic chromosome condensation 0.000841063 10 NaN INCENP;NCAPG2;SMC4
trametinib Kinase inhibitor Yes MSN01 Down Mitotic H3 phosphorylation and dephosphorylation 0.000157878 7 NaN AURKB;CCNA2;INCENP
trametinib Kinase inhibitor Yes MSN05 Down Mitotic H3 phosphorylation and dephosphorylation 0.000336392 8 NaN AURKB;CCNA2;INCENP
trametinib Kinase inhibitor Yes MSN08 Down Mitotic H3 phosphorylation and dephosphorylation 0.000251283 7.5 NaN AURKB;CCNA2;INCENP
trametinib Kinase inhibitor Yes MSN09 Down Mitotic H3 phosphorylation and dephosphorylation 0.000253492 6 NaN AURKB;CCNA2;INCENP
trametinib Kinase inhibitor Yes MSN01 Down Mitotic spindle assembly 1.13E-05 4 NaN DLGAP5;NUSAP1;TACC3;TPX2;TTK
trametinib Kinase inhibitor Yes MSN05 Down Mitotic spindle assembly 3.89E-05 5 NaN DLGAP5;NUSAP1;TACC3;TPX2;TTK
trametinib Kinase inhibitor Yes MSN08 Down Mitotic spindle assembly 2.42E-05 5 NaN DLGAP5;NUSAP1;TACC3;TPX2;TTK
trametinib Kinase inhibitor Yes MSN09 Down Mitotic spindle assembly 2.45E-05 3 NaN DLGAP5;NUSAP1;TACC3;TPX2;TTK
trametinib Kinase inhibitor Yes MSN01 Down Mitotic spindle disassembly 0.025494001 26 NaN CDK1
trametinib Kinase inhibitor Yes MSN09 Down Mitotic spindle disassembly 0.029904728 27.5 NaN CDK1
trametinib Kinase inhibitor Yes MSN05 Down Natriuretic peptide receptor signaling 0.014835138 22 NaN NPPA;NPPB
trametinib Kinase inhibitor Yes MSN08 Down Natriuretic peptide receptor signaling 0.012280307 23 NaN NPPA;NPPB
trametinib Kinase inhibitor Yes MSN09 Down Natriuretic peptide receptor signaling 0.012350245 20.5 NaN NPPA;NPPB
trametinib Kinase inhibitor Yes MSN05 Down Nuclear intermediate filaments 0.014835138 22 NaN LMNB1;LMNB2
trametinib Kinase inhibitor Yes MSN08 Down Nuclear intermediate filaments 0.012280307 23 NaN LMNB1;LMNB2
trametinib Kinase inhibitor Yes MSN09 Down Osteopontin receptor signaling 0.029904728 27.5 NaN SPP1
trametinib Kinase inhibitor Yes MSN01 Down Platelet-derived growth factor receptor signaling 0.030604726 30 14 Down by cardiotoxic TKIs PDGFRA;TNK2
trametinib Kinase inhibitor Yes MSN08 Down Platelet-derived growth factor receptor signaling 0.003627561 15 14 Down by cardiotoxic TKIs PDGFRA;PDGFRB;TNK2
trametinib Kinase inhibitor Yes MSN05 Up Potassium transmembrane transport 0.041630095 8.5 7 Up by cardiotoxic TKIs ABCC9;SLC12A6
trametinib Kinase inhibitor Yes MSN08 Up Potassium transmembrane transport 0.000565038 2 7 Up by cardiotoxic TKIs ABCC9;ATP1A2;FXYD1;SLC12A6
trametinib Kinase inhibitor Yes MSN09 Up Potassium transmembrane transport 0.007238399 2.5 7 Up by cardiotoxic TKIs ABCC9;ATP1A2;SLC12A6
trametinib Kinase inhibitor Yes MSN05 Down Pyrimidine synthesis and salvage 0.026511442 27.5 NaN TK1;TYMS
trametinib Kinase inhibitor Yes MSN08 Down Pyrimidine synthesis and salvage 0.022035993 27 NaN TK1;TYMS
trametinib Kinase inhibitor Yes MSN09 Down Pyrimidine synthesis and salvage 0.022158893 24 NaN TK1;TYMS
trametinib Kinase inhibitor Yes MSN05 Down Retinol metabolism 0.000651322 10 NaN ALDH1A1;ALDH1A3;DHRS3;RDH10
trametinib Kinase inhibitor Yes MSN09 Down Retinol metabolism 0.000453515 7 NaN ALDH1A1;ALDH1A3;DHRS3;RDH10
trametinib Kinase inhibitor Yes MSN05 Up Semaphorin signaling 0.010810161 2 NaN NRP2;SEMA6A;SEMA6D
trametinib Kinase inhibitor Yes MSN08 Up Semaphorin signaling 0.017656862 7 NaN NRP2;SEMA6A;SEMA6D
trametinib Kinase inhibitor Yes MSN09 Up Semaphorin signaling 0.018943017 6 NaN NRP2;SEMA6A;SEMA6D
trametinib Kinase inhibitor Yes MSN01 Up Serine and glycine metabolism 0.001236434 4 19 Up by cardiotoxic TKIs PHGDH;SHMT2;SLC1A5
trametinib Kinase inhibitor Yes MSN08 Up Serotonin and melatonin synthesis 0.048168598 12.5 NaN SLC6A4
trametinib Kinase inhibitor Yes MSN01 Down Sister chromatid attachment to mitotic spindle 0.000647752 9 NaN NUF2;TACC3
trametinib Kinase inhibitor Yes MSN05 Down Sister chromatid attachment to mitotic spindle 0.001079867 12 NaN NUF2;TACC3
trametinib Kinase inhibitor Yes MSN08 Down Sister chromatid attachment to mitotic spindle 0.000886472 11 NaN NUF2;TACC3
trametinib Kinase inhibitor Yes MSN09 Down Sister chromatid attachment to mitotic spindle 0.000891733 10 NaN NUF2;TACC3
trametinib Kinase inhibitor Yes MSN01 Down Sister chromatid segregation 0.000309793 8 NaN ESPL1;PTTG1;TOP2A
trametinib Kinase inhibitor Yes MSN05 Down Sister chromatid segregation 0.000656363 11 NaN ESPL1;PTTG1;TOP2A
trametinib Kinase inhibitor Yes MSN08 Down Sister chromatid segregation 0.000491456 9 NaN ESPL1;PTTG1;TOP2A
trametinib Kinase inhibitor Yes MSN09 Down Sister chromatid segregation 0.000495743 8 NaN ESPL1;PTTG1;TOP2A
trametinib Kinase inhibitor Yes MSN01 Up Thin myofilament organization 0.000278703 2 NaN ACTA1;LMOD3;TNNI3
trametinib Kinase inhibitor Yes MSN08 Up Thin myofilament organization 0.005270942 3 NaN ACTA1;LMOD3
trametinib Kinase inhibitor Yes MSN09 Down Thin myofilament organization 0.016951006 22 21 Down by cardiotoxic TKIs ACTA1;TNNI3
trametinib Kinase inhibitor Yes MSN01 Down Thrombospondin receptor signaling 6.44E-05 6 NaN THBS1;THBS2;THBS4
trametinib Kinase inhibitor Yes MSN05 Down Thrombospondin receptor signaling 0.000137929 6 NaN THBS1;THBS2;THBS4
trametinib Kinase inhibitor Yes MSN08 Down Thrombospondin receptor signaling 0.000102789 6 NaN THBS1;THBS2;THBS4
trametinib Kinase inhibitor Yes MSN09 Down Thrombospondin receptor signaling 0.005140644 15.5 NaN THBS1;THBS4
trametinib Kinase inhibitor Yes MSN09 Down Tight junction organization 0.017966495 23 NaN CLDN1;CLDN6;CRB2;MYLK
trametinib Kinase inhibitor Yes MSN01 Up Tropoelastin synthesis 0.020465773 8 NaN ELN
trametinib Kinase inhibitor Yes MSN09 Down Tropoelastin synthesis 0.029904728 27.5 NaN ELN
trametinib Kinase inhibitor Yes MSN01 Up Vasoactive intestinal peptide receptor signaling 0.040514466 10.5 NaN VIPR2
trametinib Kinase inhibitor Yes MSN01 Down Versican synthesis 0.025494001 26 NaN VCAN
trametinib Kinase inhibitor Yes MSN09 Down Versican synthesis 0.029904728 27.5 NaN VCAN
trametinib Kinase inhibitor Yes MSN01 Up Water transmembrane transport 0.010765432 5.5 NaN AQP3;AQP7
trametinib Kinase inhibitor Yes MSN01 Up WNT-Beta-catenin signaling pathway 0.041836543 12 NaN AMER1;FZD1;FZD2;SFRP2
trametinib Kinase inhibitor Yes MSN08 Up WNT-Beta-catenin signaling pathway 0.020407614 8 NaN AMER1;FZD1;FZD2;SFRP1
trametinib Kinase inhibitor Yes MSN01 Up Z-disc organization 0.000256358 1 NaN CSRP3;DES;PDLIM3;TCAP
trametinib Kinase inhibitor Yes MSN08 Up Aggrecan synthesis 0.016319689 6 NaN ACAN
trametinib Kinase inhibitor Yes MSN09 Up Aggrecan synthesis 0.016760762 4.5 NaN ACAN
trametinib Kinase inhibitor Yes MSN01 Down Albumin mediated blood protein transport 0.025494001 26 NaN ALB
trametinib Kinase inhibitor Yes MSN01 Down Alternative complement pathway 0.006155642 15 NaN C3;CFH
trametinib Kinase inhibitor Yes MSN05 Up Androgen receptor signaling 0.026986707 5 NaN AR
trametinib Kinase inhibitor Yes MSN08 Up Androgen receptor signaling 0.032374463 9 NaN AR
trametinib Kinase inhibitor Yes MSN09 Up Androgen receptor signaling 0.033242055 9 NaN AR
trametinib Kinase inhibitor Yes MSN05 Down Axonal intermediate filament dynamics 0.020320935 24.5 NaN NEFL;NES
trametinib Kinase inhibitor Yes MSN01 Down Biglycan synthesis 0.025494001 26 18 Down by cardiotoxic TKIs BGN
trametinib Kinase inhibitor Yes MSN09 Down Biglycan synthesis 0.029904728 27.5 18 Down by cardiotoxic TKIs BGN
trametinib Kinase inhibitor Yes MSN08 Up Cardiomyocyte pacemaker current generation 0.006952765 4 NaN CACNA1D;CACNA1G
trametinib Kinase inhibitor Yes MSN05 Up Cardiomyocyte repolarization during action potential and hyperpolarization 0.014991487 4 NaN KCNIP2;KCNQ5
trametinib Kinase inhibitor Yes MSN09 Up Cardiomyocyte repolarization during action potential and hyperpolarization 0.022276912 7 NaN KCNIP2;KCNQ5
trametinib Kinase inhibitor Yes MSN09 Up Caveolin-mediated endocytosis 0.049448514 13 NaN CAV1
trametinib Kinase inhibitor Yes MSN01 Down CCN intercellular signaling protein family receptor signaling 0.006155642 15 NaN CTGF;CYR61
trametinib Kinase inhibitor Yes MSN05 Down CCN intercellular signaling protein family receptor signaling 0.01010888 20 NaN CTGF;CYR61
trametinib Kinase inhibitor Yes MSN09 Up CD44-Mediated leukocyte rolling 0.033242055 9 NaN CD44
trametinib Kinase inhibitor Yes MSN05 Up Cellular iron storage 0.040207462 6.5 NaN FTL
trametinib Kinase inhibitor Yes MSN08 Up Cellular iron storage 0.048168598 12.5 NaN FTL
trametinib Kinase inhibitor Yes MSN08 Down Centrosome duplication 0.005983039 20 NaN CCNF;CEP152;PLK4;STIL
trametinib Kinase inhibitor Yes MSN01 Down Centrosome maturation 0.003040976 11.5 NaN AURKA;PLK1;TPX2
trametinib Kinase inhibitor Yes MSN05 Down Centrosome maturation 0.006230507 17.5 NaN AURKA;PLK1;TPX2
trametinib Kinase inhibitor Yes MSN08 Down Centrosome maturation 0.004730779 16.5 NaN AURKA;PLK1;TPX2
trametinib Kinase inhibitor Yes MSN09 Down Centrosome maturation 0.004770148 13.5 NaN AURKA;PLK1;TPX2
trametinib Kinase inhibitor Yes MSN01 Down Centrosome organization 0.007595905 17 NaN ASPM;CEP152;NEK2;POC1A;TACC3;WDR62
trametinib Kinase inhibitor Yes MSN05 Down Centrosome organization 0.024067422 26 NaN ASPM;NEK2;POC1A;TACC3;TUBG1;WDR62
trametinib Kinase inhibitor Yes MSN08 Down Centrosome organization 0.00089418 12 NaN ASPM;CEP152;NEK2;PLK4;POC1A;STIL;TACC3;WDR62
trametinib Kinase inhibitor Yes MSN01 Down Centrosome separation 6.98E-12 1 NaN AURKA;CCNB1;CDK1;ESPL1;KIF11;NEK2;NEK6;SPAG5
trametinib Kinase inhibitor Yes MSN05 Down Centrosome separation 5.42E-11 1 NaN AURKA;CCNB1;CDK1;ESPL1;KIF11;NEK2;NEK6;SPAG5
trametinib Kinase inhibitor Yes MSN08 Down Centrosome separation 2.46E-11 2 NaN AURKA;CCNB1;CDK1;ESPL1;KIF11;NEK2;NEK6;SPAG5
trametinib Kinase inhibitor Yes MSN09 Down Centrosome separation 2.52E-11 1 NaN AURKA;CCNB1;CDK1;ESPL1;KIF11;NEK2;NEK6;SPAG5
trametinib Kinase inhibitor Yes MSN08 Down Cholesterol synthesis 0.020558376 26 NaN DHCR24;DHCR7;MVK
trametinib Kinase inhibitor Yes MSN01 Down Collagen fibril organization by fibril-associated bridges 0.009078567 18.5 NaN COL14A1;COL9A1
trametinib Kinase inhibitor Yes MSN05 Down Collagen fibril organization by fibril-associated bridges 0.014835138 22 NaN COL9A1;COL9A2
trametinib Kinase inhibitor Yes MSN08 Down Collagen fibril organization by fibril-associated bridges 0.012280307 23 NaN COL9A1;COL9A2
trametinib Kinase inhibitor Yes MSN09 Down Collagen fibril organization by fibril-associated bridges 0.012350245 20.5 NaN COL9A1;COL9A2
trametinib Kinase inhibitor Yes MSN01 Down Contractile ring constriction 0.006155642 15 NaN ANLN;ECT2
trametinib Kinase inhibitor Yes MSN05 Down Contractile ring constriction 0.000336392 8 NaN ANLN;ECT2;MYLK
trametinib Kinase inhibitor Yes MSN08 Down Contractile ring constriction 0.000251283 7.5 NaN ANLN;ECT2;MYLK
trametinib Kinase inhibitor Yes MSN09 Down Contractile ring constriction 0.008398745 18.5 NaN ANLN;MYLK
trametinib Kinase inhibitor Yes MSN05 Up Decorin synthesis 0.013585039 3 NaN DCN
trametinib Kinase inhibitor Yes MSN09 Up Decorin synthesis 0.016760762 4.5 NaN DCN
trametinib Kinase inhibitor Yes MSN05 Down Desaturation of fatty acids 0.020320935 24.5 NaN FADS2;SCD
trametinib Kinase inhibitor Yes MSN08 Down Desaturation of fatty acids 0.016856005 25 NaN FADS2;SCD
trametinib Kinase inhibitor Yes MSN09 Down Desaturation of fatty acids 0.000848344 9 NaN FADS2;FADS3;SCD
trametinib Kinase inhibitor Yes MSN05 Down DNA replication elongation 0.000336392 8 NaN MCM5;MCM7;PCNA
trametinib Kinase inhibitor Yes MSN08 Down DNA replication elongation 0.00835069 21 NaN MCM4;MCM5
trametinib Kinase inhibitor Yes MSN09 Down DNA replication elongation 0.008398745 18.5 NaN MCM5;MCM7
trametinib Kinase inhibitor Yes MSN05 Down DNA replication initiation 1.14E-05 4 NaN CDC45;CDC6;GINS1;GINS2;MCM10;MCM5;MCM7
trametinib Kinase inhibitor Yes MSN08 Down DNA replication initiation 3.99E-07 3 NaN CDC45;CDC6;GINS1;GINS2;MCM10;MCM4;MCM5;MCM6
trametinib Kinase inhibitor Yes MSN09 Down DNA replication initiation 7.49E-05 5 NaN CDC45;CDC6;GINS2;MCM10;MCM5;MCM7
trametinib Kinase inhibitor Yes MSN08 Up Elastin cross-linking and assembly 0.048168598 12.5 NaN LOX
trametinib Kinase inhibitor Yes MSN05 Down Epithelial intermediate filament dynamics 0.026511442 27.5 NaN KRT7;KRT8
trametinib Kinase inhibitor Yes MSN09 Down Epithelial intermediate filament dynamics 0.001327345 11 NaN KRT19;KRT7;KRT8
trametinib Kinase inhibitor Yes MSN01 Down Equatorial RhoA activation 0.003756536 13 NaN ECT2;KIF23
trametinib Kinase inhibitor Yes MSN05 Down Equatorial RhoA activation 0.006199885 15.5 NaN ECT2;KIF23
trametinib Kinase inhibitor Yes MSN08 Down Equatorial RhoA activation 0.005110927 18.5 NaN ECT2;KIF23
tofacitinib Kinase inhibitor No MSN09 Down Actin filament bundling and crosslinking 0.032545775 15 NaN PLS3;SYNPO;TAGLN
tofacitinib Kinase inhibitor No MSN05 Down Adrenergic receptor signaling 0.026672865 13 NaN RAPGEF4;RGS16;RGS4
tofacitinib Kinase inhibitor No MSN08 Down Adrenergic receptor signaling 0.02789576 15 NaN RAPGEF4;RASD1;RGS4
tofacitinib Kinase inhibitor No MSN01 Down Aggrecan synthesis 0.026287932 12.5 NaN ACAN
tofacitinib Kinase inhibitor No MSN05 Down Aggrecan synthesis 0.025141143 11 NaN ACAN
tofacitinib Kinase inhibitor No MSN06 Down Aggrecan synthesis 0.026287932 13.5 NaN ACAN
tofacitinib Kinase inhibitor No MSN08 Down Aggrecan synthesis 0.025582216 12.5 NaN ACAN
tofacitinib Kinase inhibitor No MSN09 Down Aggrecan synthesis 0.027170078 12.5 NaN ACAN
tofacitinib Kinase inhibitor No MSN01 Up Albumin mediated blood protein transport 0.018348624 7 NaN ALB
tofacitinib Kinase inhibitor No MSN05 Up Albumin mediated blood protein transport 0.019671842 9.5 NaN ALB
tofacitinib Kinase inhibitor No MSN08 Up Albumin mediated blood protein transport 0.018260409 7 NaN ALB
tofacitinib Kinase inhibitor No MSN09 Up Albumin mediated blood protein transport 0.018436838 8 NaN ALB
tofacitinib Kinase inhibitor No MSN01 Up Androgen receptor signaling 0.036362165 11 NaN AR
tofacitinib Kinase inhibitor No MSN05 Up Androgen receptor signaling 0.038958404 14.5 NaN AR
tofacitinib Kinase inhibitor No MSN08 Up Androgen receptor signaling 0.036188958 13 NaN AR
tofacitinib Kinase inhibitor No MSN06 Down Antigen presentation via MHC class I molecules 0.026961659 15 NaN HLA-B;HLA-C
tofacitinib Kinase inhibitor No MSN08 Down Antigen presentation via MHC class I molecules 0.025627571 14 NaN HLA-B;HLA-C
tofacitinib Kinase inhibitor No MSN09 Down Antigen presentation via MHC class I molecules 0.028669216 14 NaN HLA-B;HLA-C
tofacitinib Kinase inhibitor No MSN01 Up Biglycan synthesis 0.018348624 7 NaN BGN
tofacitinib Kinase inhibitor No MSN05 Up Biglycan synthesis 0.019671842 9.5 NaN BGN
tofacitinib Kinase inhibitor No MSN06 Up Biglycan synthesis 0.019230769 9 NaN BGN
tofacitinib Kinase inhibitor No MSN09 Up Biglycan synthesis 0.018436838 8 NaN BGN
tofacitinib Kinase inhibitor No MSN01 Up CCN intercellular signaling protein family receptor signaling 5.93E-05 2 NaN CTGF;CYR61;WISP1
tofacitinib Kinase inhibitor No MSN05 Up CCN intercellular signaling protein family receptor signaling 0.003704726 4 NaN CTGF;CYR61
tofacitinib Kinase inhibitor No MSN06 Up CCN intercellular signaling protein family receptor signaling 0.003543247 4.5 NaN CTGF;WISP1
tofacitinib Kinase inhibitor No MSN08 Up CCN intercellular signaling protein family receptor signaling 5.84E-05 2 NaN CTGF;CYR61;WISP1
tofacitinib Kinase inhibitor No MSN01 Up Cellular fatty acid uptake 0.036362165 11 NaN CD36
tofacitinib Kinase inhibitor No MSN05 Up Cellular fatty acid uptake 0.038958404 14.5 NaN CD36
tofacitinib Kinase inhibitor No MSN09 Up Cellular fatty acid uptake 0.036535356 11.5 NaN CD36
tofacitinib Kinase inhibitor No MSN06 Up Centrosome separation 0.014964605 7 NaN CCNB1;SPAG5
tofacitinib Kinase inhibitor No MSN01 Up Chaperone-mediated autophagy 0.036362165 11 NaN HSPA8
tofacitinib Kinase inhibitor No MSN05 Up Chaperone-mediated autophagy 0.038958404 14.5 NaN HSPA8
tofacitinib Kinase inhibitor No MSN06 Up Chaperone-mediated autophagy 0.03809338 14 NaN HSPA8
tofacitinib Kinase inhibitor No MSN08 Up Chaperone-mediated autophagy 0.036188958 13 NaN HSPA8
tofacitinib Kinase inhibitor No MSN09 Up Chaperone-mediated autophagy 0.036535356 11.5 NaN HSPA8
tofacitinib Kinase inhibitor No MSN09 Down Chloride transmembrane transport 0.047110708 17.5 NaN ANO1;BEST1
tofacitinib Kinase inhibitor No MSN01 Down Cholesterol synthesis 6.93E-10 1 NaN CYP51A1;DHCR24;DHCR7;HMGCR;HMGCS1;MSMO1;MVD;SC5D;SQLE
tofacitinib Kinase inhibitor No MSN06 Down Cholesterol synthesis 9.13E-15 1 NaN CYP51A1;DHCR24;DHCR7;FDFT1;FDPS;HMGCR;HMGCS1;LSS;MSMO1;MVD;SC5D;SQLE
tofacitinib Kinase inhibitor No MSN09 Down Cholesterol synthesis 0.016074254 9 NaN DHCR7;MSMO1;SC5D
tofacitinib Kinase inhibitor No MSN01 Down Cholesterol-sensitive control of SREBP activation 0.009633191 6.5 NaN INSIG1;SREBF1
tofacitinib Kinase inhibitor No MSN05 Down Cholesterol-sensitive control of SREBP activation 0.008836966 6 NaN INSIG1;SREBF1
tofacitinib Kinase inhibitor No MSN06 Down Cholesterol-sensitive control of SREBP activation 0.009633191 7.5 NaN INSIG1;SREBF1
tofacitinib Kinase inhibitor No MSN08 Down Cholesterol-sensitive control of SREBP activation 0.009139439 7.5 NaN INSIG1;SREBF1
tofacitinib Kinase inhibitor No MSN09 Down Cholesterol-sensitive control of SREBP activation 0.010267232 6.5 NaN INSIG1;SREBF1
tofacitinib Kinase inhibitor No MSN01 Down Classical complement pathway 0.013253688 8.5 NaN C1QA;C1R
tofacitinib Kinase inhibitor No MSN05 Down Classical complement pathway 0.012167509 7 NaN C1QA;C1R
tofacitinib Kinase inhibitor No MSN06 Down Classical complement pathway 0.013253688 10 NaN C1QA;C1R
tofacitinib Kinase inhibitor No MSN08 Down Classical complement pathway 0.012580282 9 NaN C1QA;C1R
tofacitinib Kinase inhibitor No MSN09 Down Classical complement pathway 0.014117723 8 NaN C1QA;C1R
tofacitinib Kinase inhibitor No MSN05 Up Coagulation cascade 0.022330855 11 NaN F2RL1;TFPI
tofacitinib Kinase inhibitor No MSN08 Up Coagulation cascade 0.019416232 8 NaN F2RL1;TFPI
tofacitinib Kinase inhibitor No MSN01 Up Collagen fibril organization by fibril-associated bridges 0.000116919 3 NaN COL12A1;COL14A1;COL9A1
tofacitinib Kinase inhibitor No MSN05 Up Collagen fibril organization by fibril-associated bridges 0.005485195 5.5 NaN COL12A1;COL14A1
tofacitinib Kinase inhibitor No MSN06 Up Collagen fibril organization by fibril-associated bridges 0.005247657 6 NaN COL14A1;COL9A1
tofacitinib Kinase inhibitor No MSN08 Up Collagen fibril organization by fibril-associated bridges 0.000115256 3 NaN COL12A1;COL14A1;COL9A1
tofacitinib Kinase inhibitor No MSN01 Down Collagen fibril organization by fibril-associated bridges 0.009633191 6.5 NaN COL9A2;COL9A3
tofacitinib Kinase inhibitor No MSN06 Down Collagen fibril organization by fibril-associated bridges 0.009633191 7.5 NaN COL9A2;COL9A3
tofacitinib Kinase inhibitor No MSN09 Down Collagen fibril organization by fibril-associated bridges 0.010267232 6.5 NaN COL9A2;COL9A3
tofacitinib Kinase inhibitor No MSN06 Up Contractile ring constriction 0.003543247 4.5 NaN ANLN;MYLK
tofacitinib Kinase inhibitor No MSN08 Up Contractile ring constriction 0.003200174 5 NaN ANLN;MYLK
tofacitinib Kinase inhibitor No MSN01 Up Decorin synthesis 0.018348624 7 NaN DCN
tofacitinib Kinase inhibitor No MSN06 Up Decorin synthesis 0.019230769 9 NaN DCN
tofacitinib Kinase inhibitor No MSN09 Up Decorin synthesis 0.018436838 8 NaN DCN
tofacitinib Kinase inhibitor No MSN06 Down Desaturation of fatty acids 0.013253688 10 NaN FADS2;SCD
tofacitinib Kinase inhibitor No MSN06 Up DNA replication elongation 6.82E-05 3 NaN MCM4;MCM5;PCNA
tofacitinib Kinase inhibitor No MSN09 Up DNA replication elongation 5.53E-07 2 NaN MCM2;MCM4;MCM7;PCNA
tofacitinib Kinase inhibitor No MSN06 Up DNA replication initiation 3.16E-07 1 NaN CDC45;CDC6;MCM10;MCM3;MCM4;MCM5;MCM6
tofacitinib Kinase inhibitor No MSN08 Up DNA replication initiation 0.010265284 6 NaN CDC6;MCM5;MCM6
tofacitinib Kinase inhibitor No MSN09 Up DNA replication initiation 2.37E-07 1 NaN CDC45;CDC6;MCM2;MCM3;MCM4;MCM6;MCM7
tofacitinib Kinase inhibitor No MSN01 Down Epithelial intermediate filament dynamics 0.017367241 10 NaN KRT19;KRT8
tofacitinib Kinase inhibitor No MSN06 Down Epithelial intermediate filament dynamics 0.00091303 3 NaN KRT19;KRT8;TCHH
tofacitinib Kinase inhibitor No MSN08 Down Epithelial intermediate filament dynamics 0.016492549 10 NaN KRT19;TCHH
tofacitinib Kinase inhibitor No MSN09 Down Epithelial intermediate filament dynamics 0.018488625 10 NaN KRT19;KRT8
tofacitinib Kinase inhibitor No MSN08 Down Muscarinic receptor signaling 0.009139439 7.5 NaN CHRM4;RGS4
tofacitinib Kinase inhibitor No MSN09 Up Myofibril formation 0.013810218 4.5 NaN KLHL41;XIRP1
tofacitinib Kinase inhibitor No MSN05 Up Natriuretic peptide receptor signaling 0.005485195 5.5 NaN NPPA;NPPB
tofacitinib Kinase inhibitor No MSN01 Down Oncostatin-M receptor signaling 0.006535173 4 NaN OSMR;STAT3
tofacitinib Kinase inhibitor No MSN05 Down Oncostatin-M receptor signaling 0.005990412 5 NaN OSMR;STAT3
tofacitinib Kinase inhibitor No MSN08 Down Oncostatin-M receptor signaling 0.006197282 6 NaN OSMR;STAT3
tofacitinib Kinase inhibitor No MSN09 Down Oncostatin-M receptor signaling 0.006969423 5 NaN OSMR;STAT3
tofacitinib Kinase inhibitor No MSN01 Up Osteonectin receptor signaling 0.001962106 4 NaN SPARC;SPOCK1
tofacitinib Kinase inhibitor No MSN05 Up Osteonectin receptor signaling 0.002252017 3 NaN SPARC;SPOCK1
tofacitinib Kinase inhibitor No MSN06 Up Osteopontin receptor signaling 0.019230769 9 NaN SPP1
tofacitinib Kinase inhibitor No MSN05 Down Osteopontin receptor signaling 0.025141143 11 NaN SPP1
tofacitinib Kinase inhibitor No MSN09 Up Platelet-derived growth factor receptor signaling 0.016676089 6 NaN PDGFRA;PDGFRB
tofacitinib Kinase inhibitor No MSN06 Up Prostaglandin PGF2 alpha receptor signaling 0.03809338 14 NaN PTGFR
tofacitinib Kinase inhibitor No MSN05 Down Removal of caspase inhibition 0.049652372 19 NaN XAF1
tofacitinib Kinase inhibitor No MSN06 Up Retinol metabolism 0.024976036 11 NaN ALDH1A1;TTR
tofacitinib Kinase inhibitor No MSN08 Up Retinol metabolism 0.022673855 9 NaN ALDH1A2;TTR
tofacitinib Kinase inhibitor No MSN01 Down Retinol metabolism 0.044381109 15 NaN DHRS3;RDH10
tofacitinib Kinase inhibitor No MSN05 Down Retinol metabolism 0.040928231 15 NaN ALDH1A1;RDH10
tofacitinib Kinase inhibitor No MSN06 Down Retinol metabolism 0.044381109 16.5 NaN DHRS3;RDH10
tofacitinib Kinase inhibitor No MSN05 Up Serine and glycine metabolism 0.001102755 2 NaN PHGDH;PSAT1;SHMT2
tofacitinib Kinase inhibitor No MSN06 Down Serine and glycine metabolism 0.000133471 2 NaN PHGDH;PSAT1;SHMT2;SLC1A5
tofacitinib Kinase inhibitor No MSN09 Down Serine and glycine metabolism 0.000151646 1 NaN PHGDH;PSAT1;SHMT2;SLC1A5
tofacitinib Kinase inhibitor No MSN01 Up Serotonin inactivation 0.036362165 11 NaN MAOA
tofacitinib Kinase inhibitor No MSN05 Up Serotonin inactivation 0.038958404 14.5 NaN MAOA
tofacitinib Kinase inhibitor No MSN06 Up Serotonin inactivation 0.03809338 14 NaN MAOA
tofacitinib Kinase inhibitor No MSN08 Up Serotonin inactivation 0.036188958 13 NaN MAOA
tofacitinib Kinase inhibitor No MSN09 Up Serotonin inactivation 0.036535356 11.5 NaN MAOA
tofacitinib Kinase inhibitor No MSN05 Down Serotonin inactivation 0.049652372 19 NaN MAOB
tofacitinib Kinase inhibitor No MSN08 Down Sodium transmembrane transport 0.047614878 16 NaN SCN1A;SLC5A1;SLC5A5
tofacitinib Kinase inhibitor No MSN01 Down Thin myofilament organization 0.013253688 8.5 NaN ACTA1;TNNI3
tofacitinib Kinase inhibitor No MSN05 Down Thin myofilament organization 0.000510607 1 NaN ACTA1;NEBL;TNNI3
tofacitinib Kinase inhibitor No MSN06 Down Thin myofilament organization 0.013253688 10 NaN ACTA1;TNNI3
tofacitinib Kinase inhibitor No MSN08 Down Thin myofilament organization 0.000537331 3 NaN ACTA1;NEBL;TNNI3
tofacitinib Kinase inhibitor No MSN09 Down Thin myofilament organization 0.000641005 2 NaN ACTA1;NEBL;TNNI3
tofacitinib Kinase inhibitor No MSN08 Down Thrombospondin receptor signaling 0.003782172 4.5 NaN THBS1;THBS2
tofacitinib Kinase inhibitor No MSN01 Down Tropoelastin synthesis 0.026287932 12.5 NaN ELN
tofacitinib Kinase inhibitor No MSN05 Down Tropoelastin synthesis 0.025141143 11 NaN ELN
tofacitinib Kinase inhibitor No MSN06 Down Tropoelastin synthesis 0.026287932 13.5 NaN ELN
tofacitinib Kinase inhibitor No MSN08 Down Tropoelastin synthesis 0.025582216 12.5 NaN ELN
tofacitinib Kinase inhibitor No MSN09 Down Tropoelastin synthesis 0.027170078 12.5 NaN ELN
tofacitinib Kinase inhibitor No MSN06 Up WNT-Beta-catenin signaling pathway 0.03449629 12 NaN DACT1;DKK2;FRZB;FZD7
tofacitinib Kinase inhibitor No MSN08 Up WNT-Beta-catenin signaling pathway 0.029303797 10 NaN DKK2;FZD7;SFRP2;SFRP5
tofacitinib Kinase inhibitor No MSN05 Down Eukaryotic kinetochore dynamics 0.014752831 8 NaN CENPE;SKA2;SPC24;TTK
tofacitinib Kinase inhibitor No MSN05 Up Extracellular matrix breakdown and membrane shedding by adamalysins 0.011207265 7 NaN ADAMTS1;ADAMTS14;ADAMTS5
tofacitinib Kinase inhibitor No MSN08 Up Extracellular matrix breakdown and membrane shedding by adamalysins 0.000861504 4 NaN ADAMTS1;ADAMTS14;ADAMTS5;ADAMTS8
tofacitinib Kinase inhibitor No MSN01 Up Extracellular matrix breakdown by cathepsins 0.01368451 5 NaN CTSF;CTSV
tofacitinib Kinase inhibitor No MSN05 Up Extracellular matrix breakdown by cathepsins 0.015623688 8 NaN CTSF;CTSV
tofacitinib Kinase inhibitor No MSN09 Up Extracellular matrix breakdown by cathepsins 0.013810218 4.5 NaN CTSF;CTSV
tofacitinib Kinase inhibitor No MSN01 Up Fibrillar collagen core structure organization 2.12E-05 1 NaN COL1A1;COL1A2;COL2A1;COL3A1
tofacitinib Kinase inhibitor No MSN05 Up Fibrillar collagen core structure organization 2.79E-05 1 NaN COL1A1;COL1A2;COL2A1;COL3A1
tofacitinib Kinase inhibitor No MSN06 Up Fibrillar collagen core structure organization 5.85E-07 2 NaN COL11A1;COL1A1;COL1A2;COL2A1;COL3A1
tofacitinib Kinase inhibitor No MSN08 Up Fibrillar collagen core structure organization 2.08E-05 1 NaN COL1A1;COL1A2;COL2A1;COL3A1
tofacitinib Kinase inhibitor No MSN09 Up Fibrillar collagen core structure organization 2.16E-05 3 NaN COL1A1;COL1A2;COL2A1;COL3A1
tofacitinib Kinase inhibitor No MSN05 Up Fibulin receptor signaling 0.038958404 14.5 NaN FBLN1
tofacitinib Kinase inhibitor No MSN08 Up Fibulin receptor signaling 0.036188958 13 NaN FBLN1
tofacitinib Kinase inhibitor No MSN06 Down Glutamate and glutamine metabolism 0.044381109 16.5 NaN SLC1A5;SLC7A5
tofacitinib Kinase inhibitor No MSN09 Down Glutamate and glutamine metabolism 0.047110708 17.5 NaN SLC1A5;SLC7A5
tofacitinib Kinase inhibitor No MSN01 Down Granulocyte-colony stimulating factor receptor signaling 0.021945601 11 NaN SOCS3;STAT3
tofacitinib Kinase inhibitor No MSN05 Down Granulocyte-colony stimulating factor receptor signaling 0.020177706 9 NaN SOCS3;STAT3
tofacitinib Kinase inhibitor No MSN06 Down Granulocyte-colony stimulating factor receptor signaling 0.021945601 12 NaN SOCS3;STAT3
tofacitinib Kinase inhibitor No MSN08 Down Granulocyte-colony stimulating factor receptor signaling 0.020850038 11 NaN SOCS3;STAT3
tofacitinib Kinase inhibitor No MSN09 Down Granulocyte-colony stimulating factor receptor signaling 0.023349005 11 NaN SOCS3;STAT3
tofacitinib Kinase inhibitor No MSN05 Down Hepatocyte growth factor receptor signaling 0.049652372 19 NaN HGF
tofacitinib Kinase inhibitor No MSN01 Down Inhibition of amyloid aggregation, amyloid degradation and uptake 0.002030414 2 NaN A2M;MME
tofacitinib Kinase inhibitor No MSN05 Down Inhibition of amyloid aggregation, amyloid degradation and uptake 0.001858288 3 NaN A2M;MME
tofacitinib Kinase inhibitor No MSN06 Down Inhibition of amyloid aggregation, amyloid degradation and uptake 0.002030414 4 NaN A2M;MME
tofacitinib Kinase inhibitor No MSN08 Down Inhibition of amyloid aggregation, amyloid degradation and uptake 1.66E-05 1 NaN A2M;MME;PLAT
tofacitinib Kinase inhibitor No MSN01 Down Inhibition of apoptosis 0.038203861 14 NaN BIRC5;XAF1
tofacitinib Kinase inhibitor No MSN05 Down Inhibition of apoptosis 0.035205397 14 NaN BIRC5;XAF1
tofacitinib Kinase inhibitor No MSN09 Down Inhibition of apoptosis 0.040576702 16 NaN IFI6;XAF1
tofacitinib Kinase inhibitor No MSN05 Down Interleukin 6 receptor signaling 0.049652372 19 NaN JAK3
tofacitinib Kinase inhibitor No MSN05 Down Interleukin 7 receptor signaling 0.049652372 19 NaN JAK3
tofacitinib Kinase inhibitor No MSN05 Down JAK-STAT signaling pathway 0.046973016 16 NaN SOCS3;STAT3
tofacitinib Kinase inhibitor No MSN08 Down JAK-STAT signaling pathway 0.048468491 17 NaN SOCS3;STAT3
tofacitinib Kinase inhibitor No MSN01 Down Leptin receptor signaling 0.003990278 3 NaN SOCS3;STAT3
tofacitinib Kinase inhibitor No MSN05 Down Leptin receptor signaling 0.003654836 4 NaN SOCS3;STAT3
tofacitinib Kinase inhibitor No MSN06 Down Leptin receptor signaling 0.003990278 5 NaN SOCS3;STAT3
tofacitinib Kinase inhibitor No MSN08 Down Leptin receptor signaling 0.003782172 4.5 NaN SOCS3;STAT3
tofacitinib Kinase inhibitor No MSN09 Down Leptin receptor signaling 0.00425795 4 NaN SOCS3;STAT3
tofacitinib Kinase inhibitor No MSN01 Up Microfibril scaffold organization 0.036362165 11 NaN FBN1
tofacitinib Kinase inhibitor No MSN05 Up Microfibril scaffold organization 0.038958404 14.5 NaN FBN1
tofacitinib Kinase inhibitor No MSN08 Up Microfibril scaffold organization 0.036188958 13 NaN FBN1
tofacitinib Kinase inhibitor No MSN09 Up Microfibril scaffold organization 0.036535356 11.5 NaN FBN1
tofacitinib Kinase inhibitor No MSN01 Down Z-disc organization 0.007811597 5 NaN CSRP3;DES;PDLIM3
tofacitinib Kinase inhibitor No MSN05 Down Z-disc organization 0.000560649 2 NaN CSRP3;DES;NEBL;PDLIM3
tofacitinib Kinase inhibitor No MSN06 Down Z-disc organization 0.007811597 6 NaN CSRP3;DES;PDLIM3
tofacitinib Kinase inhibitor No MSN08 Down Z-disc organization 3.67E-05 2 NaN CSRP3;DES;NEBL;PDLIM3;TCAP
tofacitinib Kinase inhibitor No MSN09 Down Z-disc organization 0.000751011 3 NaN CSRP3;DES;NEBL;PDLIM3
tnf-alpha Cytokine MSN08 Down WNT-Beta-catenin signaling pathway 0.028954927 20 NaN APCDD1;FZD10;FZD2;PAX6;SFRP5
tnf-alpha Cytokine MSN05 Up Z-disc organization 0.006642272 11 NaN CSRP3;DYSF;TCAP
tnf-alpha Cytokine MSN01 Down Mitotic spindle assembly 0.00351239 4 NaN NUSAP1;TACC3;TPX2
tnf-alpha Cytokine MSN02 Down Mitotic spindle assembly 2.52E-05 3 NaN DLGAP5;NUSAP1;TACC3;TPX2;TTK
tnf-alpha Cytokine MSN08 Down Mitotic spindle assembly 0.000306964 4.5 NaN DLGAP5;TACC3;TPX2;TTK
tnf-alpha Cytokine MSN09 Down Mitotic spindle assembly 2.32E-05 3 NaN DLGAP5;NUSAP1;TACC3;TPX2;TTK
tnf-alpha Cytokine MSN02 Down Mitotic spindle disassembly 0.030081157 18 NaN CDK1
tnf-alpha Cytokine MSN09 Down Mitotic spindle disassembly 0.02955187 22 NaN CDK1
tnf-alpha Cytokine MSN05 Up Natriuretic peptide receptor signaling 0.008598393 12 NaN NPPA;NPR3
tnf-alpha Cytokine MSN02 Down Natriuretic peptide receptor signaling 0.012490666 14.5 NaN NPPA;NPPB
tnf-alpha Cytokine MSN08 Down Natriuretic peptide receptor signaling 0.010138932 14 NaN NPPA;NPPB
tnf-alpha Cytokine MSN09 Down Natriuretic peptide receptor signaling 0.012071583 15.5 NaN NPPA;NPPB
tnf-alpha Cytokine MSN01 Up Neuregulin receptor signaling 0.02030943 9 NaN ERBB3;SH3TC2
tnf-alpha Cytokine MSN08 Up Neuregulin receptor signaling 0.019010322 6.5 NaN ERBB3;SH3TC2
tnf-alpha Cytokine MSN01 Up Osteopontin receptor signaling 0.020465773 12 NaN SPP1
tnf-alpha Cytokine MSN05 Up Osteopontin receptor signaling 0.024788285 19 NaN SPP1
tnf-alpha Cytokine MSN06 Up Osteopontin receptor signaling 0.024347212 14.5 NaN SPP1
tnf-alpha Cytokine MSN08 Down Osteopontin receptor signaling 0.026993649 18 NaN SPP1
tnf-alpha Cytokine MSN09 Down Osteopontin receptor signaling 0.02955187 22 NaN SPP1
tnf-alpha Cytokine MSN05 Down Phosphoglyceride biosynthesis 0.019655219 7 NaN PCYT1B;PCYT2
tnf-alpha Cytokine MSN02 Down Platelet-derived growth factor receptor signaling 0.04147483 23 NaN PDGFB;TNK2
tnf-alpha Cytokine MSN06 Down Platelet-derived growth factor receptor signaling 0.02047443 11 NaN PDGFB;TNK2
tnf-alpha Cytokine MSN02 Up Potassium transmembrane transport 0.04817565 15 NaN ABCC9;SLC12A6
tnf-alpha Cytokine MSN02 Up Procollagen cleavage into collagen 0.043551386 12 NaN PCOLCE
tnf-alpha Cytokine MSN09 Up Procollagen cleavage into collagen 0.047400097 11.5 NaN PCOLCE
tnf-alpha Cytokine MSN01 Up Progesterone receptor signaling 0.020465773 12 NaN PGR
tnf-alpha Cytokine MSN05 Up Progesterone receptor signaling 0.024788285 19 NaN PGR
tnf-alpha Cytokine MSN06 Up Progesterone receptor signaling 0.024347212 14.5 NaN PGR
tnf-alpha Cytokine MSN02 Down Protein polyubiquitination 0.011292395 13 NaN ISG15;UBE2S;UCHL1
tnf-alpha Cytokine MSN05 Down Protein polyubiquitination 0.040157393 16 NaN ISG15;UCHL1
tnf-alpha Cytokine MSN06 Down Protein polyubiquitination 0.041771182 17 NaN ISG15;UCHL1
tnf-alpha Cytokine MSN09 Down Protein polyubiquitination 0.010760649 14 NaN ISG15;UBE2S;UCHL1
tnf-alpha Cytokine MSN08 Down Pyrimidine synthesis and salvage 0.018261874 16 NaN TK1;TYMS
tnf-alpha Cytokine MSN09 Down Pyrimidine synthesis and salvage 0.021669075 18 NaN TK1;TYMS
tnf-alpha Cytokine MSN02 Up Removal of caspase inhibition 0.029247909 8.5 NaN XAF1
tnf-alpha Cytokine MSN08 Up Removal of caspase inhibition 0.039131362 13.5 NaN XAF1
tnf-alpha Cytokine MSN09 Up Removal of caspase inhibition 0.031853721 9 NaN XAF1
tnf-alpha Cytokine MSN05 Down Removal of caspase inhibition 0.039823039 13.5 NaN XAF1
tnf-alpha Cytokine MSN05 Down Retinoic acid receptor signaling 0.027149894 9 NaN NR4A1;RARG
tnf-alpha Cytokine MSN05 Up Retinol metabolism 0.003583963 7 NaN ALDH1A1;ALDH1A3;CYP26A1
tnf-alpha Cytokine MSN06 Up Retinol metabolism 0.038602752 18.5 NaN ALDH1A1;ALDH1A3
tnf-alpha Cytokine MSN01 Down Retinol metabolism 0.039371914 14 NaN ALDH1A2;RDH10
tnf-alpha Cytokine MSN02 Down Retinol metabolism 0.006165206 11 NaN DHRS3;RBP1;RDH10
tnf-alpha Cytokine MSN08 Down Retinol metabolism 0.000306964 4.5 NaN ALDH1A1;ALDH1A3;RBP1;RDH10
tnf-alpha Cytokine MSN09 Down Retinol metabolism 0.000433512 5 NaN ALDH1A3;DHRS3;RBP1;RDH10
tnf-alpha Cytokine MSN02 Down Semaphorin signaling 0.003246644 8.5 NaN CRMP1;DPYSL4;FARP1;PLXNA2;SEMA6B
tnf-alpha Cytokine MSN09 Down Semaphorin signaling 0.003007696 9 NaN CRMP1;DPYSL4;FARP1;PLXNA2;SEMA6B
tnf-alpha Cytokine MSN08 Up Serine and glycine metabolism 0.001117129 2 NaN PHGDH;PSAT1;SHMT2
tnf-alpha Cytokine MSN01 Down Serine and glycine metabolism 0.028671146 12 NaN PHGDH;PSAT1
tnf-alpha Cytokine MSN02 Down Serine and glycine metabolism 0.000224525 4 NaN PHGDH;PSAT1;SHMT2;SLC1A5
tnf-alpha Cytokine MSN05 Down Serine and glycine metabolism 4.71E-05 2 NaN PHGDH;PSAT1;SHMT2;SLC1A5
tnf-alpha Cytokine MSN06 Down Serine and glycine metabolism 5.12E-05 2 NaN PHGDH;PSAT1;SHMT2;SLC1A5
tnf-alpha Cytokine MSN06 Down Serotonin inactivation 0.040687284 15 NaN MAOA
tnf-alpha Cytokine MSN01 Down Sister chromatid attachment to mitotic spindle 0.048620086 17 NaN TACC3
tnf-alpha Cytokine MSN02 Down Sister chromatid segregation 0.012490666 14.5 NaN PTTG1;TOP2A
tnf-alpha Cytokine MSN08 Down Sister chromatid segregation 0.010138932 14 NaN PTTG1;TOP2A
tnf-alpha Cytokine MSN09 Down Sister chromatid segregation 0.012071583 15.5 NaN PTTG1;TOP2A
tnf-alpha Cytokine MSN02 Up Thick myofilament organization 0.043551386 12 NaN TTN
tnf-alpha Cytokine MSN09 Up Thick myofilament organization 0.047400097 11.5 NaN TTN
tnf-alpha Cytokine MSN02 Down Thin myofilament organization 0.000863028 6.5 NaN ACTA1;TNNI3;TPM4
tnf-alpha Cytokine MSN06 Down Thin myofilament organization 0.008252285 5 NaN ACTA1;TPM2
tnf-alpha Cytokine MSN09 Down Thin myofilament organization 0.016572431 17 NaN ACTA1;TNNI3
tnf-alpha Cytokine MSN05 Up Thrombospondin receptor signaling 0.003554482 5.5 NaN THBS2;THBS4
tnf-alpha Cytokine MSN06 Up Thrombospondin receptor signaling 0.003430939 6.5 NaN THBS2;THBS4
tnf-alpha Cytokine MSN01 Down Thrombospondin receptor signaling 0.003504812 3 NaN THBS1;THBS4
tnf-alpha Cytokine MSN06 Down Tight junction organization 0.032121671 13 NaN CLDN11;CRB2;MYLK
tnf-alpha Cytokine MSN06 Up Tropoelastin synthesis 0.024347212 14.5 NaN ELN
tnf-alpha Cytokine MSN01 Down Tropoelastin synthesis 0.024611856 11 NaN ELN
tnf-alpha Cytokine MSN08 Down Tropoelastin synthesis 0.026993649 18 NaN ELN
tnf-alpha Cytokine MSN09 Down Tropoelastin synthesis 0.02955187 22 NaN ELN
tnf-alpha Cytokine MSN01 Down Urea cycle 0.008480245 6.5 NaN ARG2;ASS1
tnf-alpha Cytokine MSN05 Down Urea cycle 0.005727694 4.5 NaN ARG2;ASS1
tnf-alpha Cytokine MSN06 Down Vascular endothelial growth factor receptor signaling 0.008252285 5 NaN FLT1;KDR
tnf-alpha Cytokine MSN05 Down Vasoactive intestinal peptide receptor signaling 0.039823039 13.5 NaN VIPR1
tnf-alpha Cytokine MSN02 Down Actin polymerization 0.036714622 22 NaN ACTA1;HSPB1;PFN1;TMSB10
tnf-alpha Cytokine MSN01 Up Albumin mediated blood protein transport 0.020465773 12 NaN ALB
tnf-alpha Cytokine MSN02 Up Albumin mediated blood protein transport 0.014731828 5.5 NaN ALB
tnf-alpha Cytokine MSN05 Up Albumin mediated blood protein transport 0.024788285 19 NaN ALB
tnf-alpha Cytokine MSN06 Up Albumin mediated blood protein transport 0.024347212 14.5 NaN ALB
tnf-alpha Cytokine MSN08 Up Albumin mediated blood protein transport 0.019760056 8.5 NaN ALB
tnf-alpha Cytokine MSN09 Up Albumin mediated blood protein transport 0.016055046 6.5 NaN ALB
tnf-alpha Cytokine MSN05 Up Alternative complement pathway 0.005827311 9.5 NaN C3;CFH
tnf-alpha Cytokine MSN06 Up Alternative complement pathway 0.005626438 9.5 NaN C3;CFH
tnf-alpha Cytokine MSN08 Up Amyloid plaque organization 0.019010322 6.5 NaN APOE;COL25A1
tnf-alpha Cytokine MSN01 Up Antigen presentation via MHC class I molecules 0.000912967 2 NaN HLA-A;HLA-B;HLA-C
tnf-alpha Cytokine MSN05 Up Antigen presentation via MHC class I molecules 0.00158905 3.5 NaN HLA-A;HLA-B;HLA-C
tnf-alpha Cytokine MSN06 Up Antigen presentation via MHC class I molecules 0.001508963 4 NaN B2M;HLA-B;HLA-C
tnf-alpha Cytokine MSN01 Down Aspartate and arginine metabolism 0.001556699 2 NaN ARG2;ASS1;SLC7A1
tnf-alpha Cytokine MSN05 Down Aspartate and arginine metabolism 0.016295327 6 NaN ARG2;ASS1
tnf-alpha Cytokine MSN05 Up Biglycan synthesis 0.024788285 19 NaN BGN
tnf-alpha Cytokine MSN02 Down Biglycan synthesis 0.030081157 18 NaN BGN
tnf-alpha Cytokine MSN08 Down Biglycan synthesis 0.026993649 18 NaN BGN
tnf-alpha Cytokine MSN09 Down Biglycan synthesis 0.02955187 22 NaN BGN
tnf-alpha Cytokine MSN01 Up Cardiomyocyte depolarization during action potential 0.020465773 12 NaN SCN5A
tnf-alpha Cytokine MSN06 Up Cardiomyocyte depolarization during action potential 0.024347212 14.5 NaN SCN5A
tnf-alpha Cytokine MSN06 Down Cardiomyocyte pacemaker current generation 0.010854789 7 NaN HCN4;KCNJ5
tnf-alpha Cytokine MSN01 Up Cardiomyocyte repolarization during action potential and hyperpolarization 0.032279631 16.5 NaN KCNA1;KCNQ5
tnf-alpha Cytokine MSN02 Up Cardiomyocyte repolarization during action potential and hyperpolarization 0.017477776 7 NaN KCNIP2;KCNQ5
tnf-alpha Cytokine MSN06 Up Cardiomyocyte repolarization during action potential and hyperpolarization 0.044326811 20 NaN KCNA1;KCNQ5
tnf-alpha Cytokine MSN08 Up Cardiomyocyte repolarization during action potential and hyperpolarization 0.030256623 11 NaN KCNIP2;KCNQ5
tnf-alpha Cytokine MSN09 Up Cardiomyocyte repolarization during action potential and hyperpolarization 0.02055093 8 NaN KCNIP2;KCNQ5
tnf-alpha Cytokine MSN01 Down Cardiomyocyte repolarization during action potential and hyperpolarization 0.045202293 15 NaN KCNIP2;KCNJ2
tnf-alpha Cytokine MSN05 Down Cardiomyocyte repolarization during action potential and hyperpolarization 0.002480731 3 NaN KCNIP2;KCNJ2;KCNQ1
tnf-alpha Cytokine MSN05 Up CCN intercellular signaling protein family receptor signaling 0.005827311 9.5 NaN CTGF;CYR61
tnf-alpha Cytokine MSN06 Up Cellular cholesterol uptake and efflux 0.038602752 18.5 NaN ABCA12;SCARA3
tnf-alpha Cytokine MSN05 Down Cellular cholesterol uptake and efflux 0.027149894 9 NaN ABCA1;ABCG1
tnf-alpha Cytokine MSN06 Up Cellular fatty acid uptake 0.048103734 22.5 NaN CD36
tnf-alpha Cytokine MSN08 Up Cellular fatty acid uptake 0.039131362 13.5 NaN CD36
tnf-alpha Cytokine MSN02 Down Centrosome maturation 0.048799898 24.5 NaN PLK1;TPX2
tnf-alpha Cytokine MSN08 Down Centrosome maturation 0.04009759 21 NaN PLK1;TPX2
tnf-alpha Cytokine MSN09 Down Centrosome maturation 0.047261143 26.5 NaN PLK1;TPX2
tnf-alpha Cytokine MSN02 Down Centrosome separation 5.32E-06 1 NaN CCNB1;CDK1;KIF11;NEK2;SPAG5
tnf-alpha Cytokine MSN08 Down Centrosome separation 0.002029907 7 NaN CCNB1;KIF11;SPAG5
tnf-alpha Cytokine MSN09 Down Centrosome separation 4.88E-06 1 NaN CCNB1;CDK1;KIF11;NEK2;SPAG5
tnf-alpha Cytokine MSN01 Down Cholesterol synthesis 2.28E-13 1 NaN CYP51A1;DHCR24;DHCR7;FDPS;HMGCR;HMGCS1;MSMO1;MVD;MVK;SC5D;SQLE
tnf-alpha Cytokine MSN02 Down Cholesterol synthesis 1.92E-05 2 NaN DHCR7;MSMO1;MVD;MVK;NSDHL;SQLE
tnf-alpha Cytokine MSN05 Down Cholesterol synthesis 1.90E-06 1 NaN DHCR7;HMGCR;HMGCS1;MSMO1;MVD;MVK
tnf-alpha Cytokine MSN06 Down Cholesterol synthesis 8.74E-08 1 NaN DHCR7;HMGCR;HMGCS1;MSMO1;MVD;MVK;SQLE
tnf-alpha Cytokine MSN08 Down Cholesterol synthesis 0.000154045 2 NaN CYP51A1;DHCR7;MSMO1;MVD;SQLE
tnf-alpha Cytokine MSN09 Down Cholesterol synthesis 1.74E-05 2 NaN DHCR7;MSMO1;MVD;MVK;NSDHL;SQLE
tnf-alpha Cytokine MSN05 Down Cholesterol-sensitive control of SREBP activation 0.005727694 4.5 NaN INSIG1;SREBF1
tnf-alpha Cytokine MSN06 Down Cholesterol-sensitive control of SREBP activation 0.005975135 3 NaN INSIG1;SREBF1
tnf-alpha Cytokine MSN08 Down Collagen fiber crosslinking 0.006881519 11 NaN LOX;LOXL1
tnf-alpha Cytokine MSN01 Up Collagen fibril organization by fibril-associated bridges 0.000161702 1 NaN COL14A1;COL9A2;COL9A3
tnf-alpha Cytokine MSN02 Up Collagen fibril organization by fibril-associated bridges 6.08E-05 1 NaN COL14A1;COL19A1;COL9A3
tnf-alpha Cytokine MSN05 Up Collagen fibril organization by fibril-associated bridges 0.000285148 1 NaN COL12A1;COL9A1;COL9A2
tnf-alpha Cytokine MSN06 Up Collagen fibril organization by fibril-associated bridges 4.86E-08 1 NaN COL12A1;COL19A1;COL9A1;COL9A2;COL9A3
tnf-alpha Cytokine MSN08 Up Collagen fibril organization by fibril-associated bridges 0.005533298 3 NaN COL14A1;COL9A3
tnf-alpha Cytokine MSN09 Up Collagen fibril organization by fibril-associated bridges 7.86E-05 1 NaN COL14A1;COL19A1;COL9A3
tnf-alpha Cytokine MSN02 Down Connection of muscle sarcomere to plasma membrane 0.034610193 21 NaN DES;LIMS2
tnf-alpha Cytokine MSN06 Down Connection of muscle sarcomere to plasma membrane 0.016979423 9.5 NaN DES;LIMS2
tnf-alpha Cytokine MSN01 Down Contractile ring constriction 0.005746561 5 NaN ANLN;MYLK
tnf-alpha Cytokine MSN02 Down Contractile ring constriction 0.000257949 5 NaN ANLN;MYH14;MYLK
tnf-alpha Cytokine MSN08 Down Contractile ring constriction 0.006881519 11 NaN ANLN;MYLK
tnf-alpha Cytokine MSN09 Down Contractile ring constriction 0.008207301 12 NaN ANLN;MYLK
tnf-alpha Cytokine MSN01 Up Decorin synthesis 0.020465773 12 NaN DCN
tnf-alpha Cytokine MSN02 Up Decorin synthesis 0.014731828 5.5 NaN DCN
tnf-alpha Cytokine MSN05 Up Decorin synthesis 0.024788285 19 NaN DCN
tnf-alpha Cytokine MSN06 Up Decorin synthesis 0.024347212 14.5 NaN DCN
tnf-alpha Cytokine MSN08 Up Decorin synthesis 0.019760056 8.5 NaN DCN
tnf-alpha Cytokine MSN09 Up Decorin synthesis 0.016055046 6.5 NaN DCN
tnf-alpha Cytokine MSN01 Down Desaturation of fatty acids 0.011680465 8 NaN FADS2;SCD
tnf-alpha Cytokine MSN02 Down Desaturation of fatty acids 0.000863028 6.5 NaN FADS2;FADS3;SCD
tnf-alpha Cytokine MSN06 Down Desaturation of fatty acids 0.008252285 5 NaN FADS2;SCD
tnf-alpha Cytokine MSN09 Down Desaturation of fatty acids 0.000819463 7 NaN FADS2;FADS3;SCD
tnf-alpha Cytokine MSN09 Down DNA replication elongation 0.008207301 12 NaN MCM5;PCNA
tnf-alpha Cytokine MSN05 Down Drug and toxin export via membrane transport proteins 0.049880636 18 NaN ABCA1;ABCB6
tnf-alpha Cytokine MSN08 Down Elastin cross-linking and assembly 0.002140056 8 NaN LOX;LOXL1
tnf-alpha Cytokine MSN06 Up Endogenous control of complement activity 0.005626438 9.5 NaN CFH;CFI
tnf-alpha Cytokine MSN01 Up Epithelial intermediate filament dynamics 0.010765432 4 NaN KRT19;KRT4
tnf-alpha Cytokine MSN05 Up Epithelial intermediate filament dynamics 0.0155326 14 NaN KRT19;KRT7
tnf-alpha Cytokine MSN02 Down Epithelial intermediate filament dynamics 0.022405582 16 NaN KRT7;KRT8
tnf-alpha Cytokine MSN08 Down Epithelial intermediate filament dynamics 0.000986163 6 NaN KRT19;KRT7;KRT8
tnf-alpha Cytokine MSN09 Down Epithelial intermediate filament dynamics 0.001282499 8 NaN KRT19;KRT7;KRT8
tnf-alpha Cytokine MSN08 Up ER unfolded protein response pathway 0.010062749 4.5 NaN DDIT3;HERPUD1
tnf-alpha Cytokine MSN01 Down Eukaryotic kinetochore dynamics 0.013737565 9 NaN BUB1;CENPF;CENPU;ZWINT
tnf-alpha Cytokine MSN02 Down Eukaryotic kinetochore dynamics 0.005310417 10 NaN BUB1;CENPF;NDC80;SPC24;TTK
tnf-alpha Cytokine MSN08 Down Eukaryotic kinetochore dynamics 5.99E-05 1 NaN BUB1;CENPE;CENPF;NDC80;SPC24;TTK;ZWINT
tnf-alpha Cytokine MSN09 Down Eukaryotic kinetochore dynamics 0.000790538 6 NaN BUB1;CENPE;CENPF;NDC80;SPC24;TTK
tnf-alpha Cytokine MSN01 Up Extracellular matrix breakdown and membrane shedding by adamalysins 0.012470268 5 NaN ADAMTS1;ADAMTS5;ADAMTS6
tnf-alpha Cytokine MSN02 Up Extracellular matrix breakdown and membrane shedding by adamalysins 0.000383518 3 NaN ADAM12;ADAMTS1;ADAMTS5;ADAMTS6
tnf-alpha Cytokine MSN05 Up Extracellular matrix breakdown and membrane shedding by adamalysins 0.020755752 16 NaN ADAMTS1;ADAMTS12;ADAMTS8
tnf-alpha Cytokine MSN06 Up Extracellular matrix breakdown and membrane shedding by adamalysins 0.002487369 5 NaN ADAMTS1;ADAMTS5;ADAMTS6;ADAMTS8
tnf-alpha Cytokine MSN09 Up Extracellular matrix breakdown and membrane shedding by adamalysins 0.000531234 2 NaN ADAM12;ADAMTS1;ADAMTS5;ADAMTS6
tnf-alpha Cytokine MSN02 Down Extracellular matrix breakdown and membrane shedding by adamalysins 0.034214016 20 NaN ADAMTS12;ADAMTS15;ADAMTS8
tnf-alpha Cytokine MSN06 Down Extracellular matrix breakdown and membrane shedding by adamalysins 0.012615481 8 NaN ADAM33;ADAMTS14;ADAMTS2
tnf-alpha Cytokine MSN08 Down Extracellular matrix breakdown and membrane shedding by adamalysins 0.00360961 9 NaN ADAM19;ADAMTS12;ADAMTS7;ADAMTS8
tnf-alpha Cytokine MSN09 Down Extracellular matrix breakdown and membrane shedding by adamalysins 0.004984789 10 NaN ADAM19;ADAMTS12;ADAMTS15;ADAMTS8
tnf-alpha Cytokine MSN06 Down Extracellular matrix breakdown by cathepsins 0.016979423 9.5 NaN CTSF;CTSZ
tnf-alpha Cytokine MSN09 Down Extracellular matrix breakdown by cathepsins 0.033495803 25 NaN CTSV;CTSZ
tnf-alpha Cytokine MSN05 Up Extrinsic apoptosis pathway 0.011841806 13 NaN FAS;TNFRSF10A
tnf-alpha Cytokine MSN01 Up Fibrillar collagen core structure organization 0.016841612 8 NaN COL2A1;COL3A1
tnf-alpha Cytokine MSN02 Up Fibrillar collagen core structure organization 0.000349234 2 NaN COL11A1;COL11A2;COL3A1
tnf-alpha Cytokine MSN05 Up Fibrillar collagen core structure organization 0.00158905 3.5 NaN COL11A1;COL1A2;COL2A1
tnf-alpha Cytokine MSN06 Up Fibrillar collagen core structure organization 0.023362497 11 NaN COL1A2;COL3A1
tnf-alpha Cytokine MSN08 Up Fibrillar collagen core structure organization 0.000824437 1 NaN COL11A2;COL1A1;COL3A1
tnf-alpha Cytokine MSN09 Up Fibrillar collagen core structure organization 0.010599032 4 NaN COL11A2;COL3A1
tnf-alpha Cytokine MSN01 Up Fibroblast growth factor receptor signaling 0.024046558 15 NaN ANOS1;FGF18
tnf-alpha Cytokine MSN02 Down G2 M transition checkpoint 0.048799898 24.5 NaN CCNB1;CDK1
tnf-alpha Cytokine MSN09 Down G2 M transition checkpoint 0.047261143 26.5 NaN CCNB1;CDK1
tnf-alpha Cytokine MSN05 Down Glutamate and glutamine metabolism 0.027149894 9 NaN SLC1A5;SLC7A5
tnf-alpha Cytokine MSN06 Down Glutamate and glutamine metabolism 0.028265172 12 NaN SLC1A5;SLC7A5
tnf-alpha Cytokine MSN02 Down Gluthatione conjugation 0.030081157 18 NaN GSTP1
tnf-alpha Cytokine MSN09 Down Gluthatione conjugation 0.02955187 22 NaN GSTP1
tnf-alpha Cytokine MSN01 Up Glycogen synthesis and glycogenolysis 0.041446435 20 NaN PPP1R3A;PPP1R3B
tnf-alpha Cytokine MSN08 Up Glycogen synthesis and glycogenolysis 0.038884414 12 NaN PPP1R3B;PYGM
tnf-alpha Cytokine MSN01 Down Glycolysis and Gluconeogenesis 0.018147346 10 NaN ALDOA;ENO1;LDHA
tnf-alpha Cytokine MSN09 Down Glycolysis and Gluconeogenesis 0.029238552 19 NaN ENO1;LDHA;TPI1
tnf-alpha Cytokine MSN01 Up Granulocyte macrophage colony-stimulating factor receptor signaling 0.040514466 18.5 NaN JAK2
tnf-alpha Cytokine MSN02 Up Granulocyte macrophage colony-stimulating factor receptor signaling 0.029247909 8.5 NaN JAK2
tnf-alpha Cytokine MSN05 Up Granulocyte macrophage colony-stimulating factor receptor signaling 0.048964244 23 NaN JAK2
tnf-alpha Cytokine MSN06 Up Granulocyte macrophage colony-stimulating factor receptor signaling 0.048103734 22.5 NaN JAK2
tnf-alpha Cytokine MSN01 Up Granulocyte-colony stimulating factor receptor signaling 0.013655883 6.5 NaN SOCS3;STAT3
tnf-alpha Cytokine MSN05 Up Granulocyte-colony stimulating factor receptor signaling 0.019646762 15 NaN SOCS3;STAT3
tnf-alpha Cytokine MSN06 Up Granulocyte-colony stimulating factor receptor signaling 0.001075569 2.5 NaN INPP5D;SOCS3;STAT3
tnf-alpha Cytokine MSN02 Up Hemoglobin and myoglobin synthesis 0.043551386 12 NaN MB
tnf-alpha Cytokine MSN09 Up Hemoglobin and myoglobin synthesis 0.047400097 11.5 NaN MB
tnf-alpha Cytokine MSN01 Down Hepatocyte growth factor receptor signaling 0.048620086 17 NaN HGF
tnf-alpha Cytokine MSN05 Down Hepatocyte growth factor receptor signaling 0.039823039 13.5 NaN HGF
tnf-alpha Cytokine MSN06 Down Hepatocyte growth factor receptor signaling 0.040687284 15 NaN HGF
tnf-alpha Cytokine MSN01 Up HIF-1 receptor signaling pathway 0.013655883 6.5 NaN CITED2;EGLN1
tnf-alpha Cytokine MSN05 Up HIF-1 receptor signaling pathway 0.001133031 2 NaN CITED2;EGLN1;EGLN3
tnf-alpha Cytokine MSN06 Up HIF-1 receptor signaling pathway 0.001075569 2.5 NaN CITED2;EGLN1;EGLN3
tnf-alpha Cytokine MSN08 Up Inhibin receptor signaling 0.010062749 4.5 NaN INHBE;TGFBR3
tnf-alpha Cytokine MSN02 Up Inhibition of amyloid aggregation, amyloid degradation and uptake 0.000640957 4 NaN A2M;MME
tnf-alpha Cytokine MSN09 Up Inhibition of amyloid aggregation, amyloid degradation and uptake 0.000760969 3 NaN A2M;MME
tnf-alpha Cytokine MSN08 Up Inhibition of apoptosis 0.02251881 10 NaN IFI6;XAF1
tnf-alpha Cytokine MSN09 Up Inhibition of apoptosis 0.015221369 5 NaN CFLAR;XAF1
tnf-alpha Cytokine MSN06 Up Inositol metabolism and transport 0.048103734 22.5 NaN INPP5D
tnf-alpha Cytokine MSN05 Down Insulin receptor signaling 0.035600836 11 NaN IRS1;IRS2
tnf-alpha Cytokine MSN02 Up Intracellular bridge assembly 0.043551386 12 NaN NEK7
tnf-alpha Cytokine MSN01 Up JAK-STAT signaling pathway 0.032279631 16.5 NaN SOCS3;STAT3
tnf-alpha Cytokine MSN05 Up JAK-STAT signaling pathway 0.0044785 8 NaN SOCS3;STAT3;STAT4
tnf-alpha Cytokine MSN06 Up JAK-STAT signaling pathway 0.004258398 8 NaN SOCS2;SOCS3;STAT3
tnf-alpha Cytokine MSN01 Up Leptin receptor signaling 0.002435279 3 NaN SOCS3;STAT3
tnf-alpha Cytokine MSN05 Up Leptin receptor signaling 0.003554482 5.5 NaN SOCS3;STAT3
tnf-alpha Cytokine MSN06 Up Leptin receptor signaling 0.003430939 6.5 NaN SOCS3;STAT3
tnf-alpha Cytokine MSN01 Down Lipogenesis 0.048620086 17 NaN FASN
tnf-alpha Cytokine MSN06 Down Lipogenesis 0.040687284 15 NaN FASN
tnf-alpha Cytokine MSN02 Up Lysine metabolism 0.043551386 12 NaN AASS
tnf-alpha Cytokine MSN09 Up Lysine metabolism 0.047400097 11.5 NaN AASS
tnf-alpha Cytokine MSN05 Down Mammalian target of rapamycin signaling pathway 0.044920687 17 NaN DDIT4;FLCN
tnf-alpha Cytokine MSN01 Down MAPK signaling pathway 0.036701282 13 NaN FOXM1;MAP2K3;MAP2K6
tnf-alpha Cytokine MSN02 Down Metaphase to anaphase checkpoint 0.003246644 8.5 NaN BUB1;CCNB2;CDC20;PTTG1;TTK
tnf-alpha Cytokine MSN08 Down Metaphase to anaphase checkpoint 0.000261746 3 NaN BUB1;CCNB2;CDC20;CENPE;PTTG1;TTK
tnf-alpha Cytokine MSN09 Down Metaphase to anaphase checkpoint 0.000425339 4 NaN BUB1;CCNB2;CDC20;CENPE;PTTG1;TTK
tnf-alpha Cytokine MSN01 Up Methionine cycle 0.040514466 18.5 NaN BHMT
tnf-alpha Cytokine MSN05 Up Methionine cycle 0.048964244 23 NaN BHMT
tnf-alpha Cytokine MSN06 Up Methionine cycle 0.048103734 22.5 NaN BHMT
tnf-alpha Cytokine MSN05 Up Microfibril scaffold organization 0.048964244 23 NaN FBN1
tnf-alpha Cytokine MSN01 Down Microtubule crosslinking and bundling 0.008480245 6.5 NaN DCX;MAP2
tnf-alpha Cytokine MSN08 Down Microtubule crosslinking and bundling 0.010138932 14 NaN MAP2;MTCL1
tnf-alpha Cytokine MSN05 Down Mineralocorticoid receptor signaling 0.039823039 13.5 NaN NR3C2
tnf-alpha Cytokine MSN02 Down Mitotic H3 phosphorylation and dephosphorylation 0.008495241 12 NaN AURKB;CCNA2
tnf-alpha Cytokine MSN08 Down Mitotic H3 phosphorylation and dephosphorylation 0.006881519 11 NaN AURKB;CCNA2
tnf-alpha Cytokine MSN09 Down Mitotic H3 phosphorylation and dephosphorylation 0.008207301 12 NaN AURKB;CCNA2
sunitinib Kinase inhibitor Yes MSN01 Up Extracellular matrix breakdown and membrane shedding by adamalysins 0.000102089 1 NaN ADAM33;ADAMTS15;ADAMTS5;ADAMTS6;ADAMTS8
sunitinib Kinase inhibitor Yes MSN02 Up Extracellular matrix breakdown and membrane shedding by adamalysins 0.013057005 8 NaN ADAMTS15;ADAMTS5;ADAMTS8
sunitinib Kinase inhibitor Yes MSN05 Up Extracellular matrix breakdown and membrane shedding by adamalysins 0.001117947 4 NaN ADAM33;ADAMTS15;ADAMTS5;ADAMTS8
sunitinib Kinase inhibitor Yes MSN06 Up Extracellular matrix breakdown and membrane shedding by adamalysins 0.001234155 4 NaN ADAM33;ADAMTS15;ADAMTS5;ADAMTS8
sunitinib Kinase inhibitor Yes MSN08 Up Extracellular matrix breakdown and membrane shedding by adamalysins 0.001009684 5 NaN ADAM33;ADAMTS15;ADAMTS5;ADAMTS8
sunitinib Kinase inhibitor Yes MSN09 Up Extracellular matrix breakdown and membrane shedding by adamalysins 0.001234155 5 NaN ADAM33;ADAMTS15;ADAMTS5;ADAMTS8
sunitinib Kinase inhibitor Yes MSN05 Up Extracellular matrix breakdown by cathepsins 0.015490863 7 NaN CTSF;CTSV
sunitinib Kinase inhibitor Yes MSN08 Up Extracellular matrix breakdown by cathepsins 0.01470451 7.5 NaN CTSF;CTSV
sunitinib Kinase inhibitor Yes MSN09 Up Extracellular matrix breakdown by cathepsins 0.016295327 9 NaN CTSF;CTSV
sunitinib Kinase inhibitor Yes MSN01 Up Extracellular matrix breakdown by matrix metalloproteases 0.000632653 4 NaN MMP1;MMP12;MMP3
sunitinib Kinase inhibitor Yes MSN02 Up Extracellular matrix breakdown by matrix metalloproteases 0.000682052 2 NaN MMP1;MMP12;MMP3
sunitinib Kinase inhibitor Yes MSN05 Up Extracellular matrix breakdown by matrix metalloproteases 0.000570464 2 NaN MMP12;MMP2;MMP3
sunitinib Kinase inhibitor Yes MSN06 Up Extracellular matrix breakdown by matrix metalloproteases 0.000616715 3 NaN MMP12;MMP2;MMP3
sunitinib Kinase inhibitor Yes MSN08 Up Extracellular matrix breakdown by matrix metalloproteases 0.000526515 3 NaN MMP12;MMP2;MMP3
sunitinib Kinase inhibitor Yes MSN09 Up Extracellular matrix breakdown by matrix metalloproteases 0.000616715 4 NaN MMP12;MMP2;MMP3
sunitinib Kinase inhibitor Yes MSN01 Up Fibrillar collagen core structure organization 0.00089029 5.5 NaN COL1A1;COL1A2;COL2A1
sunitinib Kinase inhibitor Yes MSN02 Up Fibrillar collagen core structure organization 0.000959425 3 NaN COL11A2;COL1A2;COL2A1
sunitinib Kinase inhibitor Yes MSN05 Up Fibrillar collagen core structure organization 6.41E-07 1 NaN COL11A2;COL1A1;COL1A2;COL2A1;COL3A1
sunitinib Kinase inhibitor Yes MSN06 Up Fibrillar collagen core structure organization 7.31E-07 2 NaN COL11A2;COL1A1;COL1A2;COL2A1;COL3A1
sunitinib Kinase inhibitor Yes MSN08 Up Fibrillar collagen core structure organization 2.46E-05 1 NaN COL11A2;COL1A1;COL1A2;COL3A1
sunitinib Kinase inhibitor Yes MSN09 Up Fibrillar collagen core structure organization 7.31E-07 1.5 NaN COL11A2;COL1A1;COL1A2;COL3A1;COL5A2
sunitinib Kinase inhibitor Yes MSN01 Down Fibulin receptor signaling 0.045175089 16 NaN FBLN1
sunitinib Kinase inhibitor Yes MSN02 Down Fibulin receptor signaling 0.044830247 16.5 NaN FBLN1
sunitinib Kinase inhibitor Yes MSN05 Down Fibulin receptor signaling 0.046036922 15 NaN FBLN1
sunitinib Kinase inhibitor Yes MSN06 Down Fibulin receptor signaling 0.045002676 11.5 NaN FBLN1
sunitinib Kinase inhibitor Yes MSN08 Down Fibulin receptor signaling 0.046209242 13.5 NaN FBLN1
sunitinib Kinase inhibitor Yes MSN09 Down Fibulin receptor signaling 0.047070608 17 NaN FBLN1
sunitinib Kinase inhibitor Yes MSN06 Up Glycolysis and Gluconeogenesis 0.010566066 9 NaN ENO1;LDHA;PFKFB4
sunitinib Kinase inhibitor Yes MSN01 Up Granulocyte macrophage colony-stimulating factor receptor signaling 0.040168784 13.5 NaN JUND
sunitinib Kinase inhibitor Yes MSN05 Up Granulocyte macrophage colony-stimulating factor receptor signaling 0.03878543 13 NaN JUND
sunitinib Kinase inhibitor Yes MSN09 Up Granulocyte macrophage colony-stimulating factor receptor signaling 0.039823039 14 NaN JUND
sunitinib Kinase inhibitor Yes MSN08 Down Growth differentiation factor receptor signaling 0.013889809 9 NaN GDF15;GDF2
sunitinib Kinase inhibitor Yes MSN09 Down Growth differentiation factor receptor signaling 0.01439434 9 NaN GDF2;GDF6
sunitinib Kinase inhibitor Yes MSN01 Down Heme degradation to bilirubin 0.001536541 6 NaN BLVRB;HMOX1
sunitinib Kinase inhibitor Yes MSN01 Down Hepatocyte growth factor receptor signaling 0.000520042 5 NaN HGF;MET
sunitinib Kinase inhibitor Yes MSN02 Down Hepatocyte growth factor receptor signaling 0.000512026 5 NaN HGF;MET
sunitinib Kinase inhibitor Yes MSN05 Down Hepatocyte growth factor receptor signaling 0.000540354 5 NaN HGF;MET
sunitinib Kinase inhibitor Yes MSN06 Down Hepatocyte growth factor receptor signaling 0.000516026 4 NaN HGF;MET
sunitinib Kinase inhibitor Yes MSN08 Down Hepatocyte growth factor receptor signaling 0.000544463 1 NaN HGF;MET
sunitinib Kinase inhibitor Yes MSN05 Down Inhibin receptor signaling 0.013789873 8 NaN INHBA;INHBE
sunitinib Kinase inhibitor Yes MSN09 Down Inhibin receptor signaling 0.01439434 9 NaN INHBA;INHBE
sunitinib Kinase inhibitor Yes MSN01 Down Inhibition of amyloid aggregation, amyloid degradation and uptake 1.18E-05 1 NaN A2M;MME;PLAT
sunitinib Kinase inhibitor Yes MSN02 Down Inhibition of amyloid aggregation, amyloid degradation and uptake 1.15E-05 1 NaN A2M;MME;PLAT
sunitinib Kinase inhibitor Yes MSN05 Down Inhibition of amyloid aggregation, amyloid degradation and uptake 1.25E-05 1 NaN A2M;MME;PLAT
sunitinib Kinase inhibitor Yes MSN06 Down Inhibition of amyloid aggregation, amyloid degradation and uptake 1.17E-05 1 NaN A2M;MME;PLAT
sunitinib Kinase inhibitor Yes MSN08 Down Inhibition of amyloid aggregation, amyloid degradation and uptake 0.001608121 2 NaN MME;PLAT
sunitinib Kinase inhibitor Yes MSN09 Down Inhibition of amyloid aggregation, amyloid degradation and uptake 1.34E-05 2 NaN A2M;MME;PLAT
sunitinib Kinase inhibitor Yes MSN01 Up Inhibition of apoptosis 0.023660622 12 NaN BIRC3;IFI6
sunitinib Kinase inhibitor Yes MSN06 Up JAK-STAT signaling pathway 0.002480731 8 NaN SOCS2;STAT1;STAT4
sunitinib Kinase inhibitor Yes MSN08 Up JAK-STAT signaling pathway 0.00212632 6 NaN SOCS2;STAT1;STAT4
sunitinib Kinase inhibitor Yes MSN02 Up Lipogenesis 0.041205645 15.5 NaN FASN
sunitinib Kinase inhibitor Yes MSN01 Down Metaphase to anaphase checkpoint 0.041922907 14 NaN CDC20;PLK3;PTTG1
sunitinib Kinase inhibitor Yes MSN02 Down Metaphase to anaphase checkpoint 0.041120613 13 NaN CDC20;PLK3;PTTG1
sunitinib Kinase inhibitor Yes MSN01 Down Methionine cycle 0.045175089 16 NaN BHMT
sunitinib Kinase inhibitor Yes MSN05 Down Methionine cycle 0.046036922 15 NaN BHMT
sunitinib Kinase inhibitor Yes MSN08 Down Methionine cycle 0.046209242 13.5 NaN BHMT
sunitinib Kinase inhibitor Yes MSN09 Down Methionine cycle 0.047070608 17 NaN BHMT
sunitinib Kinase inhibitor Yes MSN01 Up Microfibril scaffold organization 0.000409904 2 NaN FBN1;MFAP2
sunitinib Kinase inhibitor Yes MSN02 Up Microfibril scaffold organization 0.041205645 15.5 NaN FBN1
sunitinib Kinase inhibitor Yes MSN05 Up Microfibril scaffold organization 0.03878543 13 NaN FBN1
sunitinib Kinase inhibitor Yes MSN06 Up Microfibril scaffold organization 0.039823039 16 NaN FBN1
sunitinib Kinase inhibitor Yes MSN08 Up Microfibril scaffold organization 0.037747261 15 NaN FBN1
sunitinib Kinase inhibitor Yes MSN09 Up Microfibril scaffold organization 0.000402791 3 NaN FBN1;MFAP2
sunitinib Kinase inhibitor Yes MSN05 Down Mineralocorticoid receptor signaling 0.046036922 15 NaN GPER1
sunitinib Kinase inhibitor Yes MSN06 Down Mineralocorticoid receptor signaling 0.045002676 11.5 NaN GPER1
sunitinib Kinase inhibitor Yes MSN01 Down Natriuretic peptide receptor signaling 0.007340787 9.5 NaN NPPA;NPPB
sunitinib Kinase inhibitor Yes MSN02 Down Natriuretic peptide receptor signaling 0.00723107 7 NaN NPPA;NPPB
sunitinib Kinase inhibitor Yes MSN06 Down Natriuretic peptide receptor signaling 0.007285832 7.5 NaN NPPA;NPPB
sunitinib Kinase inhibitor Yes MSN02 Up Nuclear mRNA export 0.04780063 20 NaN NXF1;THOC6
sunitinib Kinase inhibitor Yes MSN06 Up Nuclear mRNA export 0.044920687 18 NaN NAB2;THOC6
sunitinib Kinase inhibitor Yes MSN01 Up Osteonectin receptor signaling 0.002393952 7.5 NaN SPARC;SPOCK1
sunitinib Kinase inhibitor Yes MSN02 Up Osteonectin receptor signaling 0.002518963 4 NaN SPARC;SPOCK1
sunitinib Kinase inhibitor Yes MSN05 Up Osteonectin receptor signaling 0.002232086 5 NaN SMOC2;SPARC
sunitinib Kinase inhibitor Yes MSN06 Up Osteonectin receptor signaling 0.002352969 6 NaN SPARC;SPOCK1
sunitinib Kinase inhibitor Yes MSN09 Up Osteonectin receptor signaling 0.002352969 6 NaN SPARC;SPOCK1
sunitinib Kinase inhibitor Yes MSN08 Up Osteopontin receptor signaling 0.01905434 10 NaN SPP1
sunitinib Kinase inhibitor Yes MSN01 Down Osteopontin receptor signaling 0.022847565 12.5 NaN SPP1
sunitinib Kinase inhibitor Yes MSN02 Down Osteopontin receptor signaling 0.022671136 9 NaN SPP1
sunitinib Kinase inhibitor Yes MSN02 Down Progesterone receptor signaling 0.022671136 9 NaN PGR
sunitinib Kinase inhibitor Yes MSN05 Down Progesterone receptor signaling 0.023288638 10.5 NaN PGR
sunitinib Kinase inhibitor Yes MSN08 Down Progesterone receptor signaling 0.023376853 10.5 NaN PGR
sunitinib Kinase inhibitor Yes MSN09 Down Progesterone receptor signaling 0.023817925 13 NaN PGR
sunitinib Kinase inhibitor Yes MSN02 Up Prostaglandin PGF2 alpha receptor signaling 0.041205645 15.5 NaN PTGFR
sunitinib Kinase inhibitor Yes MSN06 Up Prostaglandin PGF2 alpha receptor signaling 0.039823039 16 NaN PTGFR
sunitinib Kinase inhibitor Yes MSN08 Up Prostaglandin PGF2 alpha receptor signaling 0.037747261 15 NaN PTGFR
sunitinib Kinase inhibitor Yes MSN02 Up Proteasomal regulatory particle organization 0.008459104 5.5 NaN PSMC4;PSMD14
sunitinib Kinase inhibitor Yes MSN02 Up Protein polyubiquitination 0.042751342 18 NaN ISG15;UCHL1
sunitinib Kinase inhibitor Yes MSN05 Up Protein polyubiquitination 0.038254008 11 NaN ISG15;UCHL1
sunitinib Kinase inhibitor Yes MSN08 Up Protein polyubiquitination 0.036387431 13 NaN ISG15;UCHL1
sunitinib Kinase inhibitor Yes MSN09 Up Protein polyubiquitination 0.040157393 16 NaN ISG15;UCHL1
sunitinib Kinase inhibitor Yes MSN06 Up Regulation of coagulation cascade by protein C 0.002352969 6 NaN PROCR;THBD
sunitinib Kinase inhibitor Yes MSN01 Up Restriction point 0.00089029 5.5 3 Up by cardiotoxic TKIs CCND2;CDKN1A;PFKFB3
sunitinib Kinase inhibitor Yes MSN05 Up Restriction point 0.000803203 3 3 Up by cardiotoxic TKIs CCND2;CDK6;CDKN1A
sunitinib Kinase inhibitor Yes MSN06 Up Restriction point 0.016295327 10.5 3 Up by cardiotoxic TKIs CCND2;CDKN1A
sunitinib Kinase inhibitor Yes MSN08 Up Restriction point 0.000741619 4 3 Up by cardiotoxic TKIs CCND2;E2F1;PFKFB3
sunitinib Kinase inhibitor Yes MSN09 Up Restriction point 7.31E-07 1.5 3 Up by cardiotoxic TKIs CCND1;CCND2;CDK6;CDKN1A;PFKFB3
sunitinib Kinase inhibitor Yes MSN08 Up Retinol metabolism 0.024550455 12 NaN ALDH1A1;RDH10
sunitinib Kinase inhibitor Yes MSN02 Down Retinol metabolism 0.03387383 11.5 NaN ALDH1A3;DHRS3
sunitinib Kinase inhibitor Yes MSN06 Down Retinol metabolism 0.034116484 9 NaN ALDH1A3;DHRS3
sunitinib Kinase inhibitor Yes MSN09 Down Semaphorin signaling 0.046477669 15 NaN PLXNA4;PLXNC1;RND1
sunitinib Kinase inhibitor Yes MSN02 Up Serine and glycine metabolism 0.020972888 12 19 Up by cardiotoxic TKIs PHGDH;PSAT1
sunitinib Kinase inhibitor Yes MSN08 Down Serine and glycine metabolism 0.026053323 12 NaN PSAT1;SHMT2
sunitinib Kinase inhibitor Yes MSN01 Up Serotonin inactivation 0.040168784 13.5 NaN MAOA
sunitinib Kinase inhibitor Yes MSN02 Up Serotonin inactivation 0.041205645 15.5 NaN MAOA
sunitinib Kinase inhibitor Yes MSN06 Up Serotonin inactivation 0.039823039 16 NaN MAOA
sunitinib Kinase inhibitor Yes MSN02 Down Serotonin inactivation 0.044830247 16.5 NaN MAOB
sunitinib Kinase inhibitor Yes MSN05 Down Serotonin inactivation 0.046036922 15 NaN MAOB
sunitinib Kinase inhibitor Yes MSN06 Down Serotonin inactivation 0.045002676 11.5 NaN MAOB
sunitinib Kinase inhibitor Yes MSN09 Down Serotonin inactivation 0.047070608 17 NaN MAOB
sunitinib Kinase inhibitor Yes MSN01 Down Sister chromatid segregation 0.007340787 9.5 NaN ESPL1;PTTG1
sunitinib Kinase inhibitor Yes MSN05 Down Sister chromatid segregation 0.000237111 3 NaN ESPL1;PTTG1;TOP2A
sunitinib Kinase inhibitor Yes MSN06 Down Sister chromatid segregation 0.007285832 7.5 NaN PTTG1;TOP2A
sunitinib Kinase inhibitor Yes MSN09 Down Sister chromatid segregation 0.007958007 6 NaN ESPL1;PTTG1
sunitinib Kinase inhibitor Yes MSN01 Down Thin myofilament organization 0.000385498 2.5 21 Down by cardiotoxic TKIs ACTA1;LMOD3;TNNI3
sunitinib Kinase inhibitor Yes MSN02 Down Thin myofilament organization 0.000376804 4 21 Down by cardiotoxic TKIs ACTA1;LMOD3;TNNI3
sunitinib Kinase inhibitor Yes MSN05 Down Thin myofilament organization 0.01050272 7 21 Down by cardiotoxic TKIs ACTA1;LMOD3
sunitinib Kinase inhibitor Yes MSN06 Down Thin myofilament organization 0.000381135 2.5 21 Down by cardiotoxic TKIs ACTA1;LMOD3;TNNI3
sunitinib Kinase inhibitor Yes MSN08 Down Thin myofilament organization 0.010579453 7 21 Down by cardiotoxic TKIs ACTA1;TNNI3
sunitinib Kinase inhibitor Yes MSN09 Down Thin myofilament organization 0.01096695 7 21 Down by cardiotoxic TKIs ACTA1;LMOD3
sunitinib Kinase inhibitor Yes MSN01 Up Thrombospondin receptor signaling 0.002393952 7.5 NaN THBS1;THBS2
sunitinib Kinase inhibitor Yes MSN06 Up Thrombospondin receptor signaling 0.002352969 6 NaN THBS1;THBS4
sunitinib Kinase inhibitor Yes MSN02 Down Thrombospondin receptor signaling 0.002980769 6 NaN THBS2;THBS4
sunitinib Kinase inhibitor Yes MSN02 Up Tight junction organization 0.033182637 13 NaN CLDN11;CLDN6;MYLK
sunitinib Kinase inhibitor Yes MSN01 Up Tropoelastin synthesis 0.020289344 10 NaN ELN
sunitinib Kinase inhibitor Yes MSN02 Up Tropoelastin synthesis 0.020818631 10 NaN ELN
sunitinib Kinase inhibitor Yes MSN05 Up Tropoelastin synthesis 0.019583627 9 NaN ELN
sunitinib Kinase inhibitor Yes MSN06 Up Tropoelastin synthesis 0.020112915 13 NaN ELN
sunitinib Kinase inhibitor Yes MSN08 Up Tropoelastin synthesis 0.01905434 10 NaN ELN
sunitinib Kinase inhibitor Yes MSN09 Up Tropoelastin synthesis 0.020112915 11 NaN ELN
sunitinib Kinase inhibitor Yes MSN08 Up Vasoactive intestinal peptide receptor signaling 0.037747261 15 NaN VIPR2
sunitinib Kinase inhibitor Yes MSN09 Up Vasoactive intestinal peptide receptor signaling 0.039823039 14 NaN VIPR2
sunitinib Kinase inhibitor Yes MSN02 Down Vasoactive intestinal peptide receptor signaling 0.044830247 16.5 NaN VIPR1
sunitinib Kinase inhibitor Yes MSN01 Up WNT-Beta-catenin signaling pathway 0.040737529 15 NaN AXIN2;FZD2;LEF1;WNT5A
sunitinib Kinase inhibitor Yes MSN02 Up WNT-Beta-catenin signaling pathway 0.044085052 19 NaN FZD2;FZD8;SFRP5;WNT5A
sunitinib Kinase inhibitor Yes MSN05 Up WNT-Beta-catenin signaling pathway 0.008226445 6 NaN AXIN2;FZD2;FZD8;PAX6;WNT5A
sunitinib Kinase inhibitor Yes MSN08 Up WNT-Beta-catenin signaling pathway 0.000204525 2 NaN AXIN2;DACT1;FZD2;FZD8;PAX6;SFRP5;WNT5A
sunitinib Kinase inhibitor Yes MSN01 Down Z-disc organization 0.000390166 4 NaN CSRP3;DYSF;PDLIM3;TCAP
sunitinib Kinase inhibitor Yes MSN02 Down Z-disc organization 2.05E-05 2 NaN CSRP3;DES;DYSF;PDLIM3;TCAP
sunitinib Kinase inhibitor Yes MSN05 Down Z-disc organization 0.005585744 6 NaN DYSF;PDLIM3;TCAP
sunitinib Kinase inhibitor Yes MSN06 Down Z-disc organization 0.00523916 6 NaN DES;PDLIM3;TCAP
sunitinib Kinase inhibitor Yes MSN02 Up Acetylcholine-mediated control of postsynaptic potential 0.008459104 5.5 NaN AGRN;CHRNA1
sunitinib Kinase inhibitor Yes MSN01 Down Aggrecan synthesis 0.022847565 12.5 NaN ACAN
sunitinib Kinase inhibitor Yes MSN02 Down Aggrecan synthesis 0.022671136 9 NaN ACAN
sunitinib Kinase inhibitor Yes MSN05 Down Aggrecan synthesis 0.023288638 10.5 NaN ACAN
sunitinib Kinase inhibitor Yes MSN09 Down Aggrecan synthesis 0.023817925 13 NaN ACAN
sunitinib Kinase inhibitor Yes MSN01 Up Albumin mediated blood protein transport 0.020289344 10 NaN ALB
sunitinib Kinase inhibitor Yes MSN02 Up Albumin mediated blood protein transport 0.020818631 10 NaN ALB
sunitinib Kinase inhibitor Yes MSN05 Up Albumin mediated blood protein transport 0.019583627 9 NaN ALB
sunitinib Kinase inhibitor Yes MSN06 Up Albumin mediated blood protein transport 0.020112915 13 NaN ALB
sunitinib Kinase inhibitor Yes MSN08 Up Albumin mediated blood protein transport 0.01905434 10 NaN ALB
sunitinib Kinase inhibitor Yes MSN09 Up Albumin mediated blood protein transport 0.020112915 11 NaN ALB
sunitinib Kinase inhibitor Yes MSN01 Down Alternative complement pathway 0.004968548 8 NaN C3;CFH
sunitinib Kinase inhibitor Yes MSN09 Down Alternative complement pathway 0.005389806 4.5 NaN C1S;CFH
sunitinib Kinase inhibitor Yes MSN05 Up Androgen receptor signaling 0.03878543 13 NaN AR
sunitinib Kinase inhibitor Yes MSN09 Up Androgen receptor signaling 0.039823039 14 NaN AR
sunitinib Kinase inhibitor Yes MSN06 Up Antigen presentation via MHC class I molecules 0.016295327 10.5 NaN HLA-B;HLA-C
sunitinib Kinase inhibitor Yes MSN08 Up Antigen presentation via MHC class I molecules 0.01470451 7.5 NaN HLA-B;HLA-C
sunitinib Kinase inhibitor Yes MSN08 Down Axonal intermediate filament dynamics 0.010579453 7 NaN NEFH;NEFM
sunitinib Kinase inhibitor Yes MSN01 Up Biglycan synthesis 0.020289344 10 NaN BGN
sunitinib Kinase inhibitor Yes MSN02 Up Biglycan synthesis 0.020818631 10 NaN BGN
sunitinib Kinase inhibitor Yes MSN05 Up Biglycan synthesis 0.019583627 9 NaN BGN
sunitinib Kinase inhibitor Yes MSN06 Up Biglycan synthesis 0.020112915 13 NaN BGN
sunitinib Kinase inhibitor Yes MSN09 Up Biglycan synthesis 0.020112915 11 NaN BGN
sunitinib Kinase inhibitor Yes MSN09 Down Cardiomyocyte pacemaker current generation 0.01439434 9 NaN CACNA1G;KCNK2
sunitinib Kinase inhibitor Yes MSN08 Down Cardiomyocyte repolarization during action potential and hyperpolarization 0.003798018 4 NaN KCNA1;KCNIP2;KCNQ1
sunitinib Kinase inhibitor Yes MSN02 Down CCN intercellular signaling protein family receptor signaling 0.000111361 3 NaN CTGF;CYR61;NOV
sunitinib Kinase inhibitor Yes MSN05 Down CCN intercellular signaling protein family receptor signaling 0.000120634 2 NaN CTGF;CYR61;WISP1
sunitinib Kinase inhibitor Yes MSN06 Down CCN intercellular signaling protein family receptor signaling 0.00493106 5 NaN CTGF;CYR61
sunitinib Kinase inhibitor Yes MSN08 Down CCN intercellular signaling protein family receptor signaling 0.005196305 5 NaN CTGF;CYR61
sunitinib Kinase inhibitor Yes MSN09 Down CCN intercellular signaling protein family receptor signaling 0.005389806 4.5 NaN CYR61;WISP1
sunitinib Kinase inhibitor Yes MSN01 Down CD44-Mediated leukocyte rolling 0.045175089 16 NaN CD44
sunitinib Kinase inhibitor Yes MSN02 Down CD44-Mediated leukocyte rolling 0.044830247 16.5 NaN CD44
sunitinib Kinase inhibitor Yes MSN05 Down CD44-Mediated leukocyte rolling 0.046036922 15 NaN CD44
sunitinib Kinase inhibitor Yes MSN06 Down CD44-Mediated leukocyte rolling 0.045002676 11.5 NaN CD44
sunitinib Kinase inhibitor Yes MSN01 Down Cellular cholesterol uptake and efflux 0.002845211 7 23 Down by cardiotoxic TKIs ABCA1;ABCG1;ARL4C
sunitinib Kinase inhibitor Yes MSN08 Down Cellular cholesterol uptake and efflux 0.003036207 3 23 Down by cardiotoxic TKIs ABCA1;ARL4C;SCARA3
sunitinib Kinase inhibitor Yes MSN09 Down Cellular cholesterol uptake and efflux 0.003201324 3 23 Down by cardiotoxic TKIs ABCA1;ABCG1;ARL4C
sunitinib Kinase inhibitor Yes MSN01 Down Centrosome separation 0.020733699 11 NaN ESPL1;SPAG5
sunitinib Kinase inhibitor Yes MSN05 Down Centrosome separation 0.021492826 9 NaN ESPL1;SPAG5
sunitinib Kinase inhibitor Yes MSN09 Down Centrosome separation 0.022419283 11 NaN ESPL1;SPAG5
sunitinib Kinase inhibitor Yes MSN02 Down Chloride transmembrane transport 0.03387383 11.5 17 Down by cardiotoxic TKIs ANO1;SLC12A7
sunitinib Kinase inhibitor Yes MSN05 Down Chloride transmembrane transport 0.035587098 12 17 Down by cardiotoxic TKIs ANO1;BEST1
sunitinib Kinase inhibitor Yes MSN01 Up Cholesterol synthesis 0.000619396 3 22 Up by cardiotoxic TKIs CYP51A1;HMGCS1;MSMO1;SC5D
sunitinib Kinase inhibitor Yes MSN02 Up Cholesterol synthesis 4.50E-05 1 22 Up by cardiotoxic TKIs HMGCR;HMGCS1;MSMO1;SC5D;SQLE
sunitinib Kinase inhibitor Yes MSN06 Up Cholesterol synthesis 7.53E-08 1 22 Up by cardiotoxic TKIs CYP51A1;DHCR24;HMGCR;HMGCS1;MSMO1;SC5D;SQLE
sunitinib Kinase inhibitor Yes MSN09 Up Cholesterol synthesis 0.007108895 8 22 Up by cardiotoxic TKIs MSMO1;SC5D;SQLE
sunitinib Kinase inhibitor Yes MSN09 Up Cholesterol-sensitive control of SREBP activation 0.005727694 7 15 Up by cardiotoxic TKIs INSIG1;SREBF1
sunitinib Kinase inhibitor Yes MSN01 Down Classical complement pathway 0.000385498 2.5 NaN C1QB;C1QC;C1R
sunitinib Kinase inhibitor Yes MSN05 Down Classical complement pathway 0.0004078 4 NaN C1QB;C1QC;C1R
sunitinib Kinase inhibitor Yes MSN06 Down Classical complement pathway 0.000381135 2.5 NaN C1QB;C1QC;C1R
sunitinib Kinase inhibitor Yes MSN08 Down Classical complement pathway 0.010579453 7 NaN C1QB;C1QC
sunitinib Kinase inhibitor Yes MSN09 Down Classical complement pathway 1.04E-05 1 NaN C1QB;C1QC;C1R;C1S
sunitinib Kinase inhibitor Yes MSN08 Down Decorin synthesis 0.023376853 10.5 NaN DCN
sunitinib Kinase inhibitor Yes MSN09 Down Decorin synthesis 0.023817925 13 NaN DCN
sunitinib Kinase inhibitor Yes MSN02 Down Eicosanoid metabolism 0.044270729 14 NaN CYP2J2;PTGS2
sunitinib Kinase inhibitor Yes MSN02 Up Epithelial intermediate filament dynamics 0.011124876 7 NaN KRT4;KRT7
sorafenib Kinase inhibitor Yes MSN01 Down Actin polymerization 0.044957827 20 NaN ABRA;ACTA1;ENAH
sorafenib Kinase inhibitor Yes MSN01 Down Albumin mediated blood protein transport 0.018966126 9 NaN ALB
sorafenib Kinase inhibitor Yes MSN05 Down Albumin mediated blood protein transport 0.020201129 12.5 NaN ALB
sorafenib Kinase inhibitor Yes MSN08 Down Albumin mediated blood protein transport 0.017907551 8 NaN ALB
sorafenib Kinase inhibitor Yes MSN09 Down Albumin mediated blood protein transport 0.02099506 12.5 NaN ALB
sorafenib Kinase inhibitor Yes MSN01 Down Antigen presentation via MHC class I molecules 0.000731661 2 NaN B2M;HLA-B;HLA-C
sorafenib Kinase inhibitor Yes MSN09 Down Antigen presentation via MHC class I molecules 0.017675877 9.5 NaN B2M;HLA-C
sorafenib Kinase inhibitor Yes MSN08 Down Biglycan synthesis 0.017907551 8 18 Down by cardiotoxic TKIs BGN
sorafenib Kinase inhibitor Yes MSN05 Down Cardiomyocyte pacemaker current generation 0.010499387 4 NaN CACNA1D;CACNA1G
sorafenib Kinase inhibitor Yes MSN08 Down Cardiomyocyte pacemaker current generation 0.008322328 3 NaN CACNA1D;CACNA1G
sorafenib Kinase inhibitor Yes MSN09 Down Cardiomyocyte pacemaker current generation 0.011306612 6 NaN CACNA1D;CACNA1G
sorafenib Kinase inhibitor Yes MSN05 Up CD44-Mediated leukocyte rolling 0.049652372 28.5 NaN CD44
sorafenib Kinase inhibitor Yes MSN09 Up CD44-Mediated leukocyte rolling 0.047931585 25.5 NaN CD44
sorafenib Kinase inhibitor Yes MSN05 Up Cell cycle arrest in response to DNA damage 0.021538908 15 NaN CDKN1A;H2AFX;MDM2
sorafenib Kinase inhibitor Yes MSN01 Up Centrosome maturation 0.003131352 12 NaN AURKA;PLK1;TPX2
sorafenib Kinase inhibitor Yes MSN05 Up Centrosome maturation 0.002923036 10 NaN AURKA;PLK1;TPX2
sorafenib Kinase inhibitor Yes MSN08 Up Centrosome maturation 0.003317085 10 NaN AURKA;PLK1;TPX2
sorafenib Kinase inhibitor Yes MSN09 Up Centrosome maturation 0.002640821 9 NaN AURKA;PLK1;TPX2
sorafenib Kinase inhibitor Yes MSN05 Up Centrosome organization 0.02793459 19 NaN ASPM;ATF5;NEK2;TACC3;WDR62
sorafenib Kinase inhibitor Yes MSN08 Up Centrosome organization 0.008770243 11 NaN ASPM;ATF5;NEK2;PLK3;TACC3;WDR62
sorafenib Kinase inhibitor Yes MSN09 Up Centrosome organization 0.006002146 12 NaN ASPM;ATF5;NEK2;PLK3;TACC3;WDR62
sorafenib Kinase inhibitor Yes MSN01 Up Centrosome separation 7.87E-10 1 NaN AURKA;CCNB1;CDK1;ESPL1;KIF11;NEK2;SPAG5
sorafenib Kinase inhibitor Yes MSN05 Up Centrosome separation 6.64E-10 1 NaN AURKA;CCNB1;CDK1;ESPL1;KIF11;NEK2;SPAG5
sorafenib Kinase inhibitor Yes MSN08 Up Centrosome separation 9.07E-10 1 NaN AURKA;CCNB1;CDK1;ESPL1;KIF11;NEK2;SPAG5
sorafenib Kinase inhibitor Yes MSN09 Up Centrosome separation 5.17E-10 1 NaN AURKA;CCNB1;CDK1;ESPL1;KIF11;NEK2;SPAG5
sorafenib Kinase inhibitor Yes MSN01 Up Cholesterol synthesis 0.000123613 2 22 Up by cardiotoxic TKIs DHCR24;DHCR7;MVD;MVK;SQLE
sorafenib Kinase inhibitor Yes MSN05 Up Cholesterol synthesis 6.90E-06 4 22 Up by cardiotoxic TKIs DHCR24;DHCR7;HMGCR;HMGCS1;MVD;MVK
sorafenib Kinase inhibitor Yes MSN01 Up Cholesterol-sensitive control of SREBP activation 0.009261749 13.5 15 Up by cardiotoxic TKIs INSIG1;SREBF1
sorafenib Kinase inhibitor Yes MSN05 Up Coagulation cascade 0.035205397 23 NaN F5;TFPI
sorafenib Kinase inhibitor Yes MSN09 Up Coagulation cascade 0.032966818 21 NaN F5;TFPI
sorafenib Kinase inhibitor Yes MSN09 Up Collagen fiber crosslinking 0.005586664 11 NaN LOXL1;PXDN
sorafenib Kinase inhibitor Yes MSN01 Down Collagen fibril organization by fibril-associated bridges 0.005107525 3 NaN COL12A1;COL9A2
sorafenib Kinase inhibitor Yes MSN08 Down Collagen fibril organization by fibril-associated bridges 0.000108759 1 NaN COL12A1;COL9A2;COL9A3
sorafenib Kinase inhibitor Yes MSN09 Down Collagen fibril organization by fibril-associated bridges 0.006227501 3 NaN COL9A2;COL9A3
sorafenib Kinase inhibitor Yes MSN05 Up Contractile ring constriction 0.005990412 12 NaN ANLN;ECT2
sorafenib Kinase inhibitor Yes MSN01 Down Decorin synthesis 0.018966126 9 NaN DCN
sorafenib Kinase inhibitor Yes MSN05 Down Decorin synthesis 0.020201129 12.5 NaN DCN
sorafenib Kinase inhibitor Yes MSN08 Down Decorin synthesis 0.017907551 8 NaN DCN
sorafenib Kinase inhibitor Yes MSN09 Down Decorin synthesis 0.02099506 12.5 NaN DCN
sorafenib Kinase inhibitor Yes MSN01 Up Desaturation of fatty acids 0.000548269 8 11 Up by cardiotoxic TKIs FADS2;FADS3;SCD
sorafenib Kinase inhibitor Yes MSN05 Up Desaturation of fatty acids 0.012167509 13.5 11 Up by cardiotoxic TKIs FADS2;SCD
sorafenib Kinase inhibitor Yes MSN08 Up Desaturation of fatty acids 0.000581947 7 11 Up by cardiotoxic TKIs FADS2;FADS3;SCD
sorafenib Kinase inhibitor Yes MSN09 Up Desaturation of fatty acids 0.011360812 14 11 Up by cardiotoxic TKIs FADS2;SCD
sorafenib Kinase inhibitor Yes MSN09 Down Eicosanoid metabolism 0.038506003 17 NaN CYP2J2;PTGES
sorafenib Kinase inhibitor Yes MSN01 Down Epithelial intermediate filament dynamics 0.000351179 1 NaN KRT19;KRT7;TCHH
sorafenib Kinase inhibitor Yes MSN05 Down Epithelial intermediate filament dynamics 0.010499387 4 NaN KRT19;KRT7
sorafenib Kinase inhibitor Yes MSN09 Down Epithelial intermediate filament dynamics 0.011306612 6 NaN KRT19;KRT7
sorafenib Kinase inhibitor Yes MSN05 Up Equatorial RhoA activation 0.003654836 11 NaN ECT2;KIF23
sorafenib Kinase inhibitor Yes MSN08 Up ER unfolded protein response pathway 0.017367241 12 NaN ATF4;HERPUD1
sorafenib Kinase inhibitor Yes MSN01 Up Mitotic spindle disassembly 0.025758645 15 NaN CDK1
sorafenib Kinase inhibitor Yes MSN05 Up Mitotic spindle disassembly 0.025141143 17 NaN CDK1
sorafenib Kinase inhibitor Yes MSN08 Up Mitotic spindle disassembly 0.026287932 13 NaN CDK1
sorafenib Kinase inhibitor Yes MSN09 Up Mitotic spindle disassembly 0.024258998 16 NaN CDK1
sorafenib Kinase inhibitor Yes MSN05 Down Myofibril formation 0.016431153 8 6 Down by cardiotoxic TKIs DES;KLHL41
sorafenib Kinase inhibitor Yes MSN01 Up Nuclear intermediate filaments 0.009261749 13.5 NaN LMNB1;LMNB2
sorafenib Kinase inhibitor Yes MSN01 Down Osteopontin receptor signaling 0.018966126 9 NaN SPP1
sorafenib Kinase inhibitor Yes MSN05 Down Osteopontin receptor signaling 0.020201129 12.5 NaN SPP1
sorafenib Kinase inhibitor Yes MSN08 Down Osteopontin receptor signaling 0.017907551 8 NaN SPP1
sorafenib Kinase inhibitor Yes MSN09 Down Osteopontin receptor signaling 0.02099506 12.5 NaN SPP1
sorafenib Kinase inhibitor Yes MSN01 Up Platelet-derived growth factor receptor signaling 0.031194976 17 NaN FOSL1;TNK2
sorafenib Kinase inhibitor Yes MSN05 Up Platelet-derived growth factor receptor signaling 0.029825004 20.5 NaN FOSL1;TNK2
sorafenib Kinase inhibitor Yes MSN08 Up Platelet-derived growth factor receptor signaling 0.032389398 14 NaN FOSL1;TNK2
sorafenib Kinase inhibitor Yes MSN09 Up Platelet-derived growth factor receptor signaling 0.027912485 18.5 NaN FOSL1;TNK2
sorafenib Kinase inhibitor Yes MSN01 Down Platelet-derived growth factor receptor signaling 0.017593716 6 14 Down by cardiotoxic TKIs PDGFRA;RGS5
sorafenib Kinase inhibitor Yes MSN05 Down Platelet-derived growth factor receptor signaling 0.019817901 10 14 Down by cardiotoxic TKIs PDGFD;PDGFRA
sorafenib Kinase inhibitor Yes MSN08 Down Platelet-derived growth factor receptor signaling 0.015780154 5 14 Down by cardiotoxic TKIs PDGFRA;RGS5
sorafenib Kinase inhibitor Yes MSN09 Down Platelet-derived growth factor receptor signaling 0.021308064 15 14 Down by cardiotoxic TKIs PDGFD;PDGFRA
sorafenib Kinase inhibitor Yes MSN01 Down Progesterone receptor signaling 0.018966126 9 NaN PGR
sorafenib Kinase inhibitor Yes MSN09 Down Prostaglandin PGF2 alpha receptor signaling 0.041551141 19.5 NaN PTGFR
sorafenib Kinase inhibitor Yes MSN05 Up Removal of caspase inhibition 0.049652372 28.5 NaN XAF1
sorafenib Kinase inhibitor Yes MSN09 Up Removal of caspase inhibition 0.047931585 25.5 NaN XAF1
sorafenib Kinase inhibitor Yes MSN01 Down Retinoic acid receptor signaling 0.024338824 12.5 NaN NR4A1;TBL1XR1
sorafenib Kinase inhibitor Yes MSN01 Down Retinol metabolism 0.024338824 12.5 NaN ALDH1A1;ALDH1A3
sorafenib Kinase inhibitor Yes MSN05 Down Retinol metabolism 0.02737145 15.5 NaN ALDH1A1;ALDH1A3
sorafenib Kinase inhibitor Yes MSN08 Down Retinol metabolism 0.021860273 11 NaN ALDH1A1;ALDH1A3
sorafenib Kinase inhibitor Yes MSN09 Down Retinol metabolism 0.029399062 16 NaN ALDH1A1;ALDH1A3
sorafenib Kinase inhibitor Yes MSN09 Up Semaphorin signaling 0.048626917 29 NaN PLXNA2;PLXNA4;RND1
sorafenib Kinase inhibitor Yes MSN01 Up Serine and glycine metabolism 0.002393839 11 19 Up by cardiotoxic TKIs PHGDH;PSAT1;SHMT2
sorafenib Kinase inhibitor Yes MSN05 Up Serine and glycine metabolism 0.029825004 20.5 19 Up by cardiotoxic TKIs PHGDH;PSAT1
sorafenib Kinase inhibitor Yes MSN08 Up Serine and glycine metabolism 0.000133471 2 19 Up by cardiotoxic TKIs PHGDH;PSAT1;SHMT2;SLC1A5
sorafenib Kinase inhibitor Yes MSN09 Up Serine and glycine metabolism 0.027912485 18.5 19 Up by cardiotoxic TKIs PHGDH;PSAT1
sorafenib Kinase inhibitor Yes MSN01 Down Serotonin inactivation 0.037574179 17 NaN MAOA
sorafenib Kinase inhibitor Yes MSN05 Down Serotonin inactivation 0.039995919 19.5 NaN MAOA
sorafenib Kinase inhibitor Yes MSN08 Down Serotonin inactivation 0.035495973 13.5 NaN MAOA
sorafenib Kinase inhibitor Yes MSN09 Down Serotonin inactivation 0.041551141 19.5 NaN MAOA
sorafenib Kinase inhibitor Yes MSN01 Up Sister chromatid attachment to mitotic spindle 0.000661294 9 NaN NUF2;TACC3
sorafenib Kinase inhibitor Yes MSN05 Up Sister chromatid attachment to mitotic spindle 0.000629915 8 NaN NUF2;TACC3
sorafenib Kinase inhibitor Yes MSN09 Up Sister chromatid attachment to mitotic spindle 0.000586411 7 NaN NUF2;TACC3
sorafenib Kinase inhibitor Yes MSN01 Up Sister chromatid segregation 0.000319382 6 NaN ESPL1;PTTG1;TOP2A
sorafenib Kinase inhibitor Yes MSN05 Up Sister chromatid segregation 0.000297304 7 NaN ESPL1;PTTG1;TOP2A
sorafenib Kinase inhibitor Yes MSN08 Up Sister chromatid segregation 0.000339137 6 NaN ESPL1;PTTG1;TOP2A
sorafenib Kinase inhibitor Yes MSN09 Up Sister chromatid segregation 0.00026753 6 NaN ESPL1;PTTG1;TOP2A
sorafenib Kinase inhibitor Yes MSN01 Down Tropoelastin synthesis 0.018966126 9 NaN ELN
sorafenib Kinase inhibitor Yes MSN05 Down Tropoelastin synthesis 0.020201129 12.5 NaN ELN
sorafenib Kinase inhibitor Yes MSN08 Down Tropoelastin synthesis 0.017907551 8 NaN ELN
sorafenib Kinase inhibitor Yes MSN09 Down Tropoelastin synthesis 0.02099506 12.5 NaN ELN
sorafenib Kinase inhibitor Yes MSN05 Up Versican receptor signaling 0.049652372 28.5 NaN VCAN
sorafenib Kinase inhibitor Yes MSN09 Up Versican receptor signaling 0.047931585 25.5 NaN VCAN
sorafenib Kinase inhibitor Yes MSN05 Up Versican synthesis 0.025141143 17 NaN VCAN
sorafenib Kinase inhibitor Yes MSN09 Up Versican synthesis 0.024258998 16 NaN VCAN
sorafenib Kinase inhibitor Yes MSN01 Up Eukaryotic kinetochore dynamics 0.000382484 7 NaN BUB1;CENPE;CENPF;NDC80;NUF2;SPC24
sorafenib Kinase inhibitor Yes MSN05 Up Eukaryotic kinetochore dynamics 3.67E-06 3 NaN BUB1;CENPE;CENPF;NDC80;NUF2;SPC24;TTK;ZWINT
sorafenib Kinase inhibitor Yes MSN08 Up Eukaryotic kinetochore dynamics 0.002991751 9 NaN BUB1;CENPE;CENPF;NDC80;SPC24
sorafenib Kinase inhibitor Yes MSN09 Up Eukaryotic kinetochore dynamics 2.82E-06 3 NaN BUB1;CENPE;CENPF;NDC80;NUF2;SPC24;TTK;ZWINT
sorafenib Kinase inhibitor Yes MSN01 Down Extracellular matrix breakdown by cathepsins 0.014575224 4.5 NaN CTSF;CTSV
sorafenib Kinase inhibitor Yes MSN05 Down Extracellular matrix breakdown by cathepsins 0.016431153 8 NaN CTSF;CTSV
sorafenib Kinase inhibitor Yes MSN08 Down Extracellular matrix breakdown by cathepsins 0.013063701 4 NaN CTSF;CTSV
sorafenib Kinase inhibitor Yes MSN01 Down Fibrillar collagen core structure organization 0.014575224 4.5 NaN COL11A1;COL3A1
sorafenib Kinase inhibitor Yes MSN05 Down Fibrillar collagen core structure organization 0.016431153 8 NaN COL1A2;COL3A1
sorafenib Kinase inhibitor Yes MSN08 Down Fibrillar collagen core structure organization 0.000618808 2 NaN COL1A1;COL1A2;COL3A1
sorafenib Kinase inhibitor Yes MSN09 Down Fibrillar collagen core structure organization 0.017675877 9.5 NaN COL1A2;COL3A1
sorafenib Kinase inhibitor Yes MSN05 Up Fibulin receptor signaling 0.049652372 28.5 NaN FBLN1
sorafenib Kinase inhibitor Yes MSN09 Up Fibulin receptor signaling 0.047931585 25.5 NaN FBLN1
sorafenib Kinase inhibitor Yes MSN01 Up G2 M transition checkpoint 0.036807701 18 NaN CCNB1;CDK1
sorafenib Kinase inhibitor Yes MSN05 Up G2 M transition checkpoint 0.035205397 23 NaN CCNB1;CDK1
sorafenib Kinase inhibitor Yes MSN08 Up G2 M transition checkpoint 0.038203861 15.5 NaN CCNB1;CDK1
sorafenib Kinase inhibitor Yes MSN09 Up G2 M transition checkpoint 0.032966818 21 NaN CCNB1;CDK1
sorafenib Kinase inhibitor Yes MSN01 Up Gap junction organization 0.04907168 19 NaN GJA5;GJB2
sorafenib Kinase inhibitor Yes MSN05 Up Gap junction organization 0.046973016 25 NaN GJA1;GJA5
sorafenib Kinase inhibitor Yes MSN09 Up Gap junction organization 0.004215197 10 NaN GJA1;GJA5;GJB2
sorafenib Kinase inhibitor Yes MSN08 Up Glutamate and glutamine metabolism 0.044381109 17 NaN SLC1A5;SLC7A5
sorafenib Kinase inhibitor Yes MSN05 Down Glutamate and glutamine metabolism 0.02737145 15.5 NaN SLC1A5;SLC38A2
sorafenib Kinase inhibitor Yes MSN05 Down Glycolysis and Gluconeogenesis 0.010692227 6 NaN HK2;LDHA;PCK2
sorafenib Kinase inhibitor Yes MSN09 Down Glycolysis and Gluconeogenesis 0.01186753 8 NaN HK2;LDHA;PGK1
sorafenib Kinase inhibitor Yes MSN01 Down Granulocyte macrophage colony-stimulating factor receptor signaling 0.037574179 17 NaN JAK2
sorafenib Kinase inhibitor Yes MSN05 Down Granulocyte macrophage colony-stimulating factor receptor signaling 0.039995919 19.5 NaN JAK2
sorafenib Kinase inhibitor Yes MSN08 Down Granulocyte macrophage colony-stimulating factor receptor signaling 0.035495973 13.5 NaN JAK2
sorafenib Kinase inhibitor Yes MSN09 Down Granulocyte macrophage colony-stimulating factor receptor signaling 0.041551141 19.5 NaN JAK2
sorafenib Kinase inhibitor Yes MSN05 Up Hepatocyte growth factor receptor signaling 0.049652372 28.5 NaN HGF
sorafenib Kinase inhibitor Yes MSN09 Up Hepatocyte growth factor receptor signaling 0.047931585 25.5 NaN HGF
sorafenib Kinase inhibitor Yes MSN05 Up Hyaluronan-mediated motility receptor signaling 0.025141143 17 NaN HMMR
sorafenib Kinase inhibitor Yes MSN09 Up Hyaluronan-mediated motility receptor signaling 0.024258998 16 NaN HMMR
sorafenib Kinase inhibitor Yes MSN05 Up Inhibition of apoptosis 0.035205397 23 NaN BIRC5;XAF1
sorafenib Kinase inhibitor Yes MSN08 Up Inhibition of apoptosis 0.038203861 15.5 NaN BIRC5;XAF1
sorafenib Kinase inhibitor Yes MSN09 Up Inhibition of apoptosis 0.032966818 21 NaN BIRC5;XAF1
sorafenib Kinase inhibitor Yes MSN05 Down Interferon alpha receptor signaling 0.010499387 4 NaN IRF9;STAT1
sorafenib Kinase inhibitor Yes MSN09 Down Interferon alpha receptor signaling 0.011306612 6 NaN IRF9;STAT1
sorafenib Kinase inhibitor Yes MSN09 Down Interferon beta receptor signaling 0.0085983 4 NaN IFIT2;IRF9
sorafenib Kinase inhibitor Yes MSN01 Up Intracellular bridge assembly 0.001950041 10 NaN INCENP;KIF23
sorafenib Kinase inhibitor Yes MSN05 Up Intracellular bridge assembly 0.001858288 9 NaN INCENP;KIF23
sorafenib Kinase inhibitor Yes MSN08 Up Intracellular bridge assembly 0.002030414 8 NaN INCENP;KIF23
sorafenib Kinase inhibitor Yes MSN09 Up Intracellular bridge assembly 0.001730983 8 NaN INCENP;KIF23
sorafenib Kinase inhibitor Yes MSN01 Down JAK-STAT signaling pathway 0.028045575 14 NaN SOCS2;STAT1
sorafenib Kinase inhibitor Yes MSN05 Down JAK-STAT signaling pathway 0.031514722 17 NaN SOCS2;STAT1
sorafenib Kinase inhibitor Yes MSN09 Down JAK-STAT signaling pathway 0.002802661 2 NaN SOCS2;SOCS3;STAT1
sorafenib Kinase inhibitor Yes MSN05 Up Lipogenesis 0.049652372 28.5 NaN FASN
sorafenib Kinase inhibitor Yes MSN09 Up Lipogenesis 0.047931585 25.5 NaN FASN
sorafenib Kinase inhibitor Yes MSN01 Down Mammalian target of rapamycin signaling pathway 0.040389424 19 NaN PIK3R1;RICTOR
sorafenib Kinase inhibitor Yes MSN05 Down Mammalian target of rapamycin signaling pathway 0.045276928 22 NaN PIK3R1;RICTOR
sorafenib Kinase inhibitor Yes MSN08 Down Mammalian target of rapamycin signaling pathway 0.036376129 16 NaN PIK3R1;RICTOR
sorafenib Kinase inhibitor Yes MSN09 Down Mammalian target of rapamycin signaling pathway 0.048531229 23 NaN PIK3R1;RICTOR
sorafenib Kinase inhibitor Yes MSN01 Up Metaphase to anaphase checkpoint 0.000203151 4 NaN BUB1;BUB1B;CDC20;CENPE;MXD3;PTTG1
sorafenib Kinase inhibitor Yes MSN05 Up Metaphase to anaphase checkpoint 1.49E-06 2 NaN BUB1;BUB1B;CCNB2;CDC20;CENPE;MXD3;PTTG1;TTK
sorafenib Kinase inhibitor Yes MSN08 Up Metaphase to anaphase checkpoint 0.00022683 4 NaN BUB1;BUB1B;CDC20;CENPE;PLK3;PTTG1
sorafenib Kinase inhibitor Yes MSN09 Up Metaphase to anaphase checkpoint 1.14E-06 2 NaN BUB1;BUB1B;CCNB2;CDC20;CENPE;PLK3;PTTG1;TTK
sorafenib Kinase inhibitor Yes MSN01 Down Methionine cycle 0.037574179 17 NaN BHMT
sorafenib Kinase inhibitor Yes MSN05 Down Methionine cycle 0.039995919 19.5 NaN BHMT
sorafenib Kinase inhibitor Yes MSN08 Down Methionine cycle 0.035495973 13.5 NaN BHMT
sorafenib Kinase inhibitor Yes MSN05 Down Microfibril scaffold organization 0.039995919 19.5 NaN FBN1
sorafenib Kinase inhibitor Yes MSN08 Down Microfibril scaffold organization 0.035495973 13.5 NaN FBN1
sorafenib Kinase inhibitor Yes MSN09 Down Microfibril scaffold organization 0.041551141 19.5 NaN FBN1
sorafenib Kinase inhibitor Yes MSN09 Up Microtubule crosslinking and bundling 0.008246232 13 NaN MAP1B;MAP2
sorafenib Kinase inhibitor Yes MSN01 Up Mitochondrial transport 0.025958406 16 NaN KIF1A;RHOT2
sorafenib Kinase inhibitor Yes MSN05 Up Mitotic chromosome condensation 0.012167509 13.5 NaN INCENP;SMC4
sorafenib Kinase inhibitor Yes MSN01 Up Mitotic H3 phosphorylation and dephosphorylation 0.000162797 3 NaN AURKB;CCNA2;INCENP
sorafenib Kinase inhibitor Yes MSN05 Up Mitotic H3 phosphorylation and dephosphorylation 0.000151472 6 NaN AURKB;CCNA2;INCENP
sorafenib Kinase inhibitor Yes MSN08 Up Mitotic H3 phosphorylation and dephosphorylation 0.000172936 3 NaN AURKB;CCNA2;INCENP
sorafenib Kinase inhibitor Yes MSN09 Up Mitotic H3 phosphorylation and dephosphorylation 0.000136211 5 NaN AURKB;CCNA2;INCENP
sorafenib Kinase inhibitor Yes MSN01 Up Mitotic spindle assembly 0.00025659 5 NaN DLGAP5;NUSAP1;TACC3;TPX2
sorafenib Kinase inhibitor Yes MSN05 Up Mitotic spindle assembly 1.06E-05 5 NaN DLGAP5;NUSAP1;TACC3;TPX2;TTK
sorafenib Kinase inhibitor Yes MSN08 Up Mitotic spindle assembly 0.00027738 5 NaN DLGAP5;NUSAP1;TACC3;TPX2
sorafenib Kinase inhibitor Yes MSN09 Up Mitotic spindle assembly 8.89E-06 4 NaN DLGAP5;NUSAP1;TACC3;TPX2;TTK
sorafenib Kinase inhibitor Yes MSN05 Down WNT-Beta-catenin signaling pathway 0.009336933 2 NaN FZD1;PAX6;SFRP2;WNT5A;WNT9A
sorafenib Kinase inhibitor Yes MSN09 Down WNT-Beta-catenin signaling pathway 0.000369348 1 NaN DKK2;FRZB;FZD7;PAX6;SFRP2;WNT5A;WNT9A
sorafenib Kinase inhibitor Yes MSN01 Down Z-disc organization 0.036079961 15 NaN CSRP3;PDLIM3
sorafenib Kinase inhibitor Yes MSN05 Down Z-disc organization 0.003750874 1 NaN CSRP3;DES;PDLIM3
sorafenib Kinase inhibitor Yes MSN09 Down Z-disc organization 0.043409684 22 NaN CSRP3;PDLIM3
saxagliptin Antidiabetic No MSN01 Down WNT-Beta-catenin signaling pathway 0.013495554 8 NaN DACT1;DKK2;FRZB;WNT2;WNT9A
saxagliptin Antidiabetic No MSN05 Down WNT-Beta-catenin signaling pathway 0.003718285 8 NaN APCDD1;DACT1;DKK2;FRZB;WNT2;WNT9A
saxagliptin Antidiabetic No MSN08 Down WNT-Beta-catenin signaling pathway 0.002626412 4 NaN DKK2;FRZB;SFRP2;SFRP4;WNT2;WNT9A
saxagliptin Antidiabetic No MSN01 Down Mitotic spindle assembly 0.002602492 6 NaN DLGAP5;NUSAP1;TPX2
saxagliptin Antidiabetic No MSN02 Down Mitotic spindle assembly 0.002602492 5.5 NaN DLGAP5;NUSAP1;TPX2
saxagliptin Antidiabetic No MSN05 Down Mitotic spindle assembly 0.003036207 6.5 NaN DLGAP5;NUSAP1;TPX2
saxagliptin Antidiabetic No MSN09 Down Mitotic spindle assembly 0.031486283 19 NaN DLGAP5;NUSAP1
saxagliptin Antidiabetic No MSN01 Down Mitotic spindle disassembly 0.022141849 14.5 NaN CDK1
saxagliptin Antidiabetic No MSN02 Down Mitotic spindle disassembly 0.022141849 12 NaN CDK1
saxagliptin Antidiabetic No MSN05 Down Mitotic spindle disassembly 0.023376853 14 NaN CDK1
saxagliptin Antidiabetic No MSN08 Down Mitotic spindle disassembly 0.021788991 10.5 NaN CDK1
saxagliptin Antidiabetic No MSN09 Down Mitotic spindle disassembly 0.021788991 15 NaN CDK1
saxagliptin Antidiabetic No MSN01 Up Natriuretic peptide receptor signaling 0.007395936 5 NaN NPPB;NPR3
saxagliptin Antidiabetic No MSN02 Up Natriuretic peptide receptor signaling 0.006960163 8 NaN NPPB;NPR3
saxagliptin Antidiabetic No MSN05 Up Natriuretic peptide receptor signaling 0.006381277 7 NaN NPPB;NPR3
saxagliptin Antidiabetic No MSN08 Up Natriuretic peptide receptor signaling 0.007562538 9.5 NaN NPPB;NPR3
saxagliptin Antidiabetic No MSN09 Up Natriuretic peptide receptor signaling 0.007176501 5 NaN NPPB;NPR3
saxagliptin Antidiabetic No MSN05 Down Neuregulin receptor signaling 0.026053323 17 NaN ERBB3;NRG1
saxagliptin Antidiabetic No MSN01 Down Osteopontin receptor signaling 0.022141849 14.5 NaN SPP1
saxagliptin Antidiabetic No MSN02 Down Osteopontin receptor signaling 0.022141849 12 NaN SPP1
saxagliptin Antidiabetic No MSN05 Down Osteopontin receptor signaling 0.023376853 14 NaN SPP1
saxagliptin Antidiabetic No MSN08 Down Osteopontin receptor signaling 0.021788991 10.5 NaN SPP1
saxagliptin Antidiabetic No MSN09 Down Osteopontin receptor signaling 0.021788991 15 NaN SPP1
saxagliptin Antidiabetic No MSN01 Down Potassium transmembrane transport 0.015397967 9 NaN ABCC9;ATP1A2;ATP1A3
saxagliptin Antidiabetic No MSN02 Down Potassium transmembrane transport 0.001758867 4 NaN ABCC9;ATP1A2;ATP1A3;KCNE4
saxagliptin Antidiabetic No MSN09 Down Potassium transmembrane transport 0.001658125 7 NaN ABCC9;ATP1A2;ATP1A3;KCNE4
saxagliptin Antidiabetic No MSN01 Down Progesterone receptor signaling 0.022141849 14.5 NaN PGR
saxagliptin Antidiabetic No MSN05 Down Prostaglandin PGF2 alpha receptor signaling 0.046209242 20 NaN PTGFR
saxagliptin Antidiabetic No MSN02 Up Protein polyubiquitination 0.048125749 15 NaN ISG15;UCHL1
saxagliptin Antidiabetic No MSN05 Up Protein polyubiquitination 0.044404489 18 NaN ISG15;UCHL1
saxagliptin Antidiabetic No MSN09 Up Protein polyubiquitination 0.049507089 14 NaN ISG15;UCHL1
saxagliptin Antidiabetic No MSN09 Down Regulation of coagulation cascade by protein C 0.002756163 8.5 NaN PROS1;THBD
saxagliptin Antidiabetic No MSN08 Up Retinoic acid receptor signaling 0.035340255 14.5 NaN NR4A1;TBL1XR1
saxagliptin Antidiabetic No MSN05 Up Retinol metabolism 0.03008824 14.5 NaN DHRS3;RLBP1
saxagliptin Antidiabetic No MSN08 Up Retinol metabolism 0.00297168 5 NaN ALDH1A2;RLBP1;RPE65
saxagliptin Antidiabetic No MSN01 Down Semaphorin signaling 0.038761798 20 NaN CRMP1;SEMA3E;SEMA6B
saxagliptin Antidiabetic No MSN01 Up Serine and glycine metabolism 0.025144066 11 NaN GLDC;PSAT1
saxagliptin Antidiabetic No MSN02 Up Serine and glycine metabolism 0.00156935 5 NaN GLDC;PSAT1;SLC1A5
saxagliptin Antidiabetic No MSN05 Up Serine and glycine metabolism 0.001380012 3 NaN GLDC;PSAT1;SLC1A5
saxagliptin Antidiabetic No MSN08 Up Serine and glycine metabolism 0.025687982 13 NaN SHMT2;SLC1A5
saxagliptin Antidiabetic No MSN09 Up Serine and glycine metabolism 0.024426533 9 NaN GLDC;PSAT1
saxagliptin Antidiabetic No MSN08 Down Serine and glycine metabolism 0.022844529 13 NaN PHGDH;PSAT1
saxagliptin Antidiabetic No MSN05 Up Serotonin inactivation 0.042069268 16.5 NaN MAOA
saxagliptin Antidiabetic No MSN08 Up Serotonin inactivation 0.045864587 18.5 NaN MAOA
saxagliptin Antidiabetic No MSN01 Down Sister chromatid attachment to mitotic spindle 0.043795347 21.5 NaN NUF2
saxagliptin Antidiabetic No MSN08 Down Sister chromatid attachment to mitotic spindle 0.043105102 15.5 NaN NUF2
saxagliptin Antidiabetic No MSN08 Up Thrombospondin receptor signaling 0.00311962 7 NaN THBS1;THBS4
saxagliptin Antidiabetic No MSN01 Up Tight junction organization 0.000985853 2 NaN CGN;CLDN11;CLDN19;EMP1;MYLK
saxagliptin Antidiabetic No MSN02 Up Tight junction organization 0.006548178 7 NaN CGN;CLDN19;EMP1;MYLK
saxagliptin Antidiabetic No MSN05 Up Tight junction organization 0.005599924 6 NaN CGN;CLDN19;EMP1;MYLK
saxagliptin Antidiabetic No MSN08 Up Tight junction organization 0.043551421 17 NaN CLDN11;EMP1;MYLK
saxagliptin Antidiabetic No MSN09 Up Tight junction organization 0.006917983 4 NaN CGN;CLDN19;EMP1;MYLK
saxagliptin Antidiabetic No MSN01 Down Tropoelastin synthesis 0.022141849 14.5 NaN ELN
saxagliptin Antidiabetic No MSN02 Down Tropoelastin synthesis 0.022141849 12 NaN ELN
saxagliptin Antidiabetic No MSN05 Down Tropoelastin synthesis 0.023376853 14 NaN ELN
saxagliptin Antidiabetic No MSN08 Down Tropoelastin synthesis 0.021788991 10.5 NaN ELN
saxagliptin Antidiabetic No MSN09 Down Tropoelastin synthesis 0.021788991 15 NaN ELN
saxagliptin Antidiabetic No MSN01 Down Actin filament bundling and crosslinking 0.019151001 11 NaN SYNPO;SYNPO2;USH1C
saxagliptin Antidiabetic No MSN02 Down Actin filament bundling and crosslinking 0.019151001 8 NaN SYNPO;SYNPO2;USH1C
saxagliptin Antidiabetic No MSN05 Down Actin filament bundling and crosslinking 0.022080775 11 NaN SYNPO;SYNPO2;USH1C
saxagliptin Antidiabetic No MSN09 Down Actin filament bundling and crosslinking 0.018356825 12 NaN SYNPO;SYNPO2;USH1C
saxagliptin Antidiabetic No MSN01 Up Actin filament severing and depolymerization 0.034603897 13 NaN SCIN;TAGLN2
saxagliptin Antidiabetic No MSN02 Up Actin filament severing and depolymerization 0.032671153 12 NaN SCIN;TAGLN2
saxagliptin Antidiabetic No MSN05 Up Actin filament severing and depolymerization 0.03008824 14.5 NaN SCIN;TAGLN2
saxagliptin Antidiabetic No MSN08 Up Actin filament severing and depolymerization 0.00297168 5 NaN LIMA1;SCIN;TAGLN2
saxagliptin Antidiabetic No MSN09 Up Actin filament severing and depolymerization 0.03363188 11 NaN SCIN;TAGLN2
saxagliptin Antidiabetic No MSN01 Up Aggrecan synthesis 0.02293578 9.5 NaN ACAN
saxagliptin Antidiabetic No MSN02 Up Aggrecan synthesis 0.022230064 10.5 NaN ACAN
saxagliptin Antidiabetic No MSN05 Up Aggrecan synthesis 0.021259704 12.5 NaN ACAN
saxagliptin Antidiabetic No MSN08 Up Aggrecan synthesis 0.023200423 12 NaN ACAN
saxagliptin Antidiabetic No MSN09 Up Aggrecan synthesis 0.022582922 7.5 NaN ACAN
saxagliptin Antidiabetic No MSN01 Down Albumin mediated blood protein transport 0.022141849 14.5 NaN ALB
saxagliptin Antidiabetic No MSN02 Down Albumin mediated blood protein transport 0.022141849 12 NaN ALB
saxagliptin Antidiabetic No MSN05 Down Albumin mediated blood protein transport 0.023376853 14 NaN ALB
saxagliptin Antidiabetic No MSN09 Down Albumin mediated blood protein transport 0.021788991 15 NaN ALB
saxagliptin Antidiabetic No MSN02 Up Androgen receptor signaling 0.043967869 13.5 NaN AR
saxagliptin Antidiabetic No MSN05 Up Androgen receptor signaling 0.042069268 16.5 NaN AR
saxagliptin Antidiabetic No MSN05 Up Antigen presentation via MHC class I molecules 0.018099639 11 NaN HLA-A;HLA-C
saxagliptin Antidiabetic No MSN01 Down Biglycan synthesis 0.022141849 14.5 NaN BGN
saxagliptin Antidiabetic No MSN02 Down Biglycan synthesis 0.022141849 12 NaN BGN
saxagliptin Antidiabetic No MSN05 Down Biglycan synthesis 0.023376853 14 NaN BGN
saxagliptin Antidiabetic No MSN08 Down Biglycan synthesis 0.021788991 10.5 NaN BGN
saxagliptin Antidiabetic No MSN09 Down Biglycan synthesis 0.021788991 15 NaN BGN
saxagliptin Antidiabetic No MSN01 Up CCN intercellular signaling protein family receptor signaling 0.00500617 4 NaN CYR61;WISP1
saxagliptin Antidiabetic No MSN05 Down CD44-Mediated leukocyte rolling 0.046209242 20 NaN CD44
saxagliptin Antidiabetic No MSN01 Down Cellular cholesterol uptake and efflux 0.000143348 2 NaN ABCA1;ABCA12;ABCG1;SCARA3
saxagliptin Antidiabetic No MSN02 Down Cellular cholesterol uptake and efflux 0.002602492 5.5 NaN ABCA1;ABCG1;SCARA3
saxagliptin Antidiabetic No MSN05 Down Cellular cholesterol uptake and efflux 0.003036207 6.5 NaN ABCA1;ABCG1;SCARA3
saxagliptin Antidiabetic No MSN08 Down Cellular cholesterol uptake and efflux 0.031486283 14 NaN ABCA1;SCARA3
saxagliptin Antidiabetic No MSN09 Down Cellular cholesterol uptake and efflux 0.000134719 2 NaN ABCA1;ABCA12;ABCG1;SCARA3
saxagliptin Antidiabetic No MSN01 Down Centrosome separation 0.001147047 4.5 NaN CCNB1;CDK1;NEK2
saxagliptin Antidiabetic No MSN02 Down Centrosome separation 0.001147047 3 NaN CCNB1;CDK1;NEK2
saxagliptin Antidiabetic No MSN05 Down Centrosome separation 0.001341925 4.5 NaN CCNB1;CDK1;NEK2
saxagliptin Antidiabetic No MSN08 Down Centrosome separation 0.018960318 8 NaN CDK1;NEK2
saxagliptin Antidiabetic No MSN09 Down Centrosome separation 0.001094912 4.5 NaN CCNB1;CDK1;NEK2
saxagliptin Antidiabetic No MSN01 Up Chloride transmembrane transport 0.034603897 13 NaN ANO1;SLC12A6
saxagliptin Antidiabetic No MSN08 Up Chloride transmembrane transport 0.035340255 14.5 NaN ANO1;SLC12A6
saxagliptin Antidiabetic No MSN09 Up Chloride transmembrane transport 0.03363188 11 NaN ANO1;SLC12A6
saxagliptin Antidiabetic No MSN05 Down Cholesterol synthesis 0.001052619 3 NaN DHCR24;HMGCR;HMGCS1;MSMO1
saxagliptin Antidiabetic No MSN01 Up Classical complement pathway 0.000389893 1 NaN C1QA;C1QB;C1QC
saxagliptin Antidiabetic No MSN02 Up Classical complement pathway 0.000355631 3 NaN C1QB;C1QC;C1R
saxagliptin Antidiabetic No MSN05 Up Classical complement pathway 0.008809063 8 NaN C1QB;C1QC
saxagliptin Antidiabetic No MSN08 Up Classical complement pathway 0.000403274 2 NaN C1QA;C1QB;C1QC
saxagliptin Antidiabetic No MSN09 Up Classical complement pathway 0.000372505 1 NaN C1QB;C1QC;C1R
saxagliptin Antidiabetic No MSN08 Up Collagen fiber crosslinking 0.005119846 8 NaN LOXL1;TGM2
saxagliptin Antidiabetic No MSN01 Down Collagen fibril organization by fibril-associated bridges 0.000204193 3 NaN COL12A1;COL14A1;COL9A1
saxagliptin Antidiabetic No MSN02 Down Collagen fibril organization by fibril-associated bridges 0.000204193 2 NaN COL12A1;COL14A1;COL9A1
saxagliptin Antidiabetic No MSN05 Down Collagen fibril organization by fibril-associated bridges 0.000239777 2 NaN COL12A1;COL14A1;COL9A1
saxagliptin Antidiabetic No MSN08 Down Collagen fibril organization by fibril-associated bridges 0.000194704 2 NaN COL12A1;COL14A1;COL9A1
saxagliptin Antidiabetic No MSN09 Down Collagen fibril organization by fibril-associated bridges 0.000194704 3 NaN COL12A1;COL14A1;COL9A1
saxagliptin Antidiabetic No MSN01 Up Decorin synthesis 0.02293578 9.5 NaN DCN
saxagliptin Antidiabetic No MSN02 Up Decorin synthesis 0.022230064 10.5 NaN DCN
saxagliptin Antidiabetic No MSN05 Up Decorin synthesis 0.021259704 12.5 NaN DCN
saxagliptin Antidiabetic No MSN09 Up Decorin synthesis 0.022582922 7.5 NaN DCN
saxagliptin Antidiabetic No MSN02 Up DNA replication elongation 0.000105033 2 NaN MCM4;MCM5;MCM7
saxagliptin Antidiabetic No MSN05 Up DNA replication elongation 9.20E-05 1 NaN MCM4;MCM5;PCNA
saxagliptin Antidiabetic No MSN01 Up DNA replication initiation 0.002339767 3 NaN CDC6;MCM10;MCM5;MCM6
saxagliptin Antidiabetic No MSN02 Up DNA replication initiation 1.41E-05 1 NaN CDC6;MCM10;MCM4;MCM5;MCM6;MCM7
saxagliptin Antidiabetic No MSN05 Up DNA replication initiation 0.001773432 4 NaN CDC6;MCM4;MCM5;MCM6
saxagliptin Antidiabetic No MSN09 Up DNA replication initiation 0.002211379 3 NaN CDC6;MCM10;MCM5;MCM6
saxagliptin Antidiabetic No MSN05 Down Epithelial intermediate filament dynamics 0.013889809 9 NaN KRT19;KRT8
saxagliptin Antidiabetic No MSN01 Up Extracellular matrix breakdown and membrane shedding by adamalysins 0.01691013 7 NaN ADAMTS2;ADAMTS5;ADAMTS9
saxagliptin Antidiabetic No MSN05 Up Extracellular matrix breakdown and membrane shedding by adamalysins 0.013812565 10 NaN ADAMTS2;ADAMTS5;ADAMTS9
saxagliptin Antidiabetic No MSN08 Up Extracellular matrix breakdown and membrane shedding by adamalysins 0.017432245 11 NaN ADAMTS2;ADAMTS5;ADAMTS9
saxagliptin Antidiabetic No MSN05 Down Extracellular matrix breakdown and membrane shedding by adamalysins 0.017785355 10 NaN ADAM12;ADAMTS12;ADAMTS14
saxagliptin Antidiabetic No MSN02 Down Extracellular matrix breakdown by serine proteases 0.009528592 7 NaN KLK5;PRSS12
saxagliptin Antidiabetic No MSN08 Down Extracellular matrix breakdown by serine proteases 0.009237654 7 NaN KLK5;PRSS12
saxagliptin Antidiabetic No MSN09 Down Extracellular matrix breakdown by serine proteases 0.009237654 10 NaN KLK5;PRSS12
saxagliptin Antidiabetic No MSN09 Down Fatty acid transfer between membranes 0.001398195 6 NaN FABP3;FABP5
saxagliptin Antidiabetic No MSN01 Up Fibrillar collagen core structure organization 0.02088458 8 NaN COL1A2;COL3A1
saxagliptin Antidiabetic No MSN02 Up Fibrillar collagen core structure organization 0.001160324 4 NaN COL1A1;COL1A2;COL3A1
saxagliptin Antidiabetic No MSN05 Up Fibrillar collagen core structure organization 0.001019591 2 NaN COL1A1;COL1A2;COL3A1
saxagliptin Antidiabetic No MSN08 Up Fibrillar collagen core structure organization 0.001312886 3 NaN COL11A2;COL1A2;COL3A1
saxagliptin Antidiabetic No MSN09 Up Fibrillar collagen core structure organization 0.001214412 2 NaN COL1A1;COL1A2;COL3A1
saxagliptin Antidiabetic No MSN01 Down Fibrillar collagen core structure organization 0.001147047 4.5 NaN COL11A1;COL2A1;COL5A2
saxagliptin Antidiabetic No MSN02 Down Fibrillar collagen core structure organization 0.019543779 9 NaN COL2A1;COL5A2
saxagliptin Antidiabetic No MSN05 Down Fibrillar collagen core structure organization 0.001341925 4.5 NaN COL11A1;COL2A1;COL5A2
saxagliptin Antidiabetic No MSN08 Down Fibrillar collagen core structure organization 4.17E-05 1 NaN COL11A1;COL2A1;COL5A1;COL5A2
saxagliptin Antidiabetic No MSN09 Down Fibrillar collagen core structure organization 0.001094912 4.5 NaN COL11A1;COL2A1;COL5A2
saxagliptin Antidiabetic No MSN01 Down Fibronectin synthesis and extracellular assembly 0.000103796 1 NaN FN1;ITGA5;ITGB3
saxagliptin Antidiabetic No MSN02 Down Fibronectin synthesis and extracellular assembly 0.000103796 1 NaN FN1;ITGA5;ITGB3
saxagliptin Antidiabetic No MSN05 Down Fibronectin synthesis and extracellular assembly 0.000121999 1 NaN FN1;ITGA5;ITGB3
saxagliptin Antidiabetic No MSN09 Down Fibronectin synthesis and extracellular assembly 9.89E-05 1 NaN FN1;ITGA5;ITGB3
saxagliptin Antidiabetic No MSN08 Down Fibulin receptor signaling 0.043105102 15.5 NaN FBLN1
saxagliptin Antidiabetic No MSN01 Down G2 M transition checkpoint 0.027843478 18 NaN CCNB1;CDK1
saxagliptin Antidiabetic No MSN02 Down G2 M transition checkpoint 0.027843478 15 NaN CCNB1;CDK1
saxagliptin Antidiabetic No MSN05 Down G2 M transition checkpoint 0.030788722 18 NaN CCNB1;CDK1
saxagliptin Antidiabetic No MSN09 Down G2 M transition checkpoint 0.027024728 18 NaN CCNB1;CDK1
saxagliptin Antidiabetic No MSN08 Up Gap junction organization 0.040610666 16 NaN GJA5;GJA8
saxagliptin Antidiabetic No MSN01 Up Glutamate and glutamine metabolism 0.034603897 13 NaN GLS;SLC7A5
saxagliptin Antidiabetic No MSN02 Up Glutamate and glutamine metabolism 0.002632093 6 NaN GLS;SLC1A5;SLC7A5
saxagliptin Antidiabetic No MSN05 Up Glutamate and glutamine metabolism 0.002317901 5 NaN GLS;SLC1A5;SLC7A5
saxagliptin Antidiabetic No MSN08 Up Glutamate and glutamine metabolism 0.00297168 5 NaN GLS;SLC1A5;SLC7A5
saxagliptin Antidiabetic No MSN09 Up Glutamate and glutamine metabolism 0.03363188 11 NaN GLS;SLC7A5
saxagliptin Antidiabetic No MSN01 Down Granulocyte-colony stimulating factor receptor signaling 0.015864433 10 NaN SOCS3;STAT3
saxagliptin Antidiabetic No MSN08 Down Granulocyte-colony stimulating factor receptor signaling 0.000778938 3 NaN CSF3R;SOCS3;STAT3
saxagliptin Antidiabetic No MSN09 Down Granulocyte-colony stimulating factor receptor signaling 0.015387237 11 NaN SOCS3;STAT3
saxagliptin Antidiabetic No MSN01 Up Hepatocyte growth factor receptor signaling 0.045347487 15 NaN HGF
saxagliptin Antidiabetic No MSN08 Up Hepatocyte growth factor receptor signaling 0.045864587 18.5 NaN HGF
saxagliptin Antidiabetic No MSN01 Up Inhibin receptor signaling 0.013393382 6 NaN INHBB;INHBE
saxagliptin Antidiabetic No MSN02 Up Inhibin receptor signaling 0.012616077 9 NaN INHBB;INHBE
saxagliptin Antidiabetic No MSN05 Up Inhibin receptor signaling 0.011581726 9 NaN INHBB;INHBE
saxagliptin Antidiabetic No MSN08 Up Inhibin receptor signaling 1.84E-05 1 NaN INHBA;INHBB;INHBE;TGFBR3
saxagliptin Antidiabetic No MSN09 Up Inhibin receptor signaling 0.013002108 6 NaN INHBB;INHBE
saxagliptin Antidiabetic No MSN01 Down JAK-STAT signaling pathway 0.037295126 19 NaN SOCS3;STAT3
saxagliptin Antidiabetic No MSN08 Down JAK-STAT signaling pathway 0.00311366 6 NaN SOCS3;STAT3;STAT4
saxagliptin Antidiabetic No MSN09 Down JAK-STAT signaling pathway 0.036215054 20 NaN SOCS3;STAT3
saxagliptin Antidiabetic No MSN01 Down Leptin receptor signaling 0.002844982 7 NaN SOCS3;STAT3
saxagliptin Antidiabetic No MSN08 Down Leptin receptor signaling 0.002756163 5 NaN SOCS3;STAT3
saxagliptin Antidiabetic No MSN09 Down Leptin receptor signaling 0.002756163 8.5 NaN SOCS3;STAT3
saxagliptin Antidiabetic No MSN02 Up Lipogenesis 0.043967869 13.5 NaN FASN
saxagliptin Antidiabetic No MSN09 Up Lipogenesis 0.044657802 13 NaN FASN
saxagliptin Antidiabetic No MSN01 Down Microfibril scaffold organization 0.043795347 21.5 NaN FBN1
saxagliptin Antidiabetic No MSN02 Down Microfibril scaffold organization 0.043795347 16 NaN FBN1
saxagliptin Antidiabetic No MSN05 Down Microfibril scaffold organization 0.046209242 20 NaN FBN1
saxagliptin Antidiabetic No MSN09 Down Microfibril scaffold organization 0.043105102 21 NaN FBN1
saxagliptin Antidiabetic No MSN08 Up Microtubule crosslinking and bundling 0.007562538 9.5 NaN DCX;MAP2
ruxolitinib Kinase inhibitor No MSN02 Down ER unfolded protein response pathway 0.014496215 8 NaN ATF4;DDIT3
ruxolitinib Kinase inhibitor No MSN06 Down ER unfolded protein response pathway 0.017036884 11.5 NaN ATF4;DDIT3
ruxolitinib Kinase inhibitor No MSN09 Down ER unfolded protein response pathway 0.017700401 11 NaN ATF4;DDIT3
ruxolitinib Kinase inhibitor No MSN01 Up Eukaryotic kinetochore dynamics 5.24E-05 4 NaN BUB1;CENPE;CENPF;MAD2L1;NDC80;ZWINT
ruxolitinib Kinase inhibitor No MSN02 Up Eukaryotic kinetochore dynamics 8.45E-09 2 NaN BUB1;CENPE;CENPF;MAD2L1;NDC80;NUF2;SKA3;SPC24;TTK;ZWINT
ruxolitinib Kinase inhibitor No MSN09 Up Eukaryotic kinetochore dynamics 0.006779643 11 NaN BUB1;CENPE;CENPF;NUF2
ruxolitinib Kinase inhibitor No MSN06 Up Extracellular matrix breakdown and membrane shedding by adamalysins 0.011207265 7 NaN ADAM12;ADAMTS14;ADAMTS5
ruxolitinib Kinase inhibitor No MSN08 Up Extracellular matrix breakdown and membrane shedding by adamalysins 0.006331148 8 NaN ADAM12;ADAMTS5;ADAMTS8
ruxolitinib Kinase inhibitor No MSN01 Up Extracellular matrix breakdown by matrix metalloproteases 0.000438946 6 NaN MMP12;MMP2;MMP3
ruxolitinib Kinase inhibitor No MSN05 Up Extracellular matrix breakdown by matrix metalloproteases 0.000298278 3 NaN MMP12;MMP2;MMP3
ruxolitinib Kinase inhibitor No MSN06 Up Extracellular matrix breakdown by matrix metalloproteases 0.012661705 8 NaN MMP12;MMP3
ruxolitinib Kinase inhibitor No MSN08 Up Extracellular matrix breakdown by matrix metalloproteases 0.000313327 3 NaN MMP12;MMP2;MMP3
ruxolitinib Kinase inhibitor No MSN02 Up Fanconi anemia interstrand cross-link repair pathway 0.020586647 20 NaN BRIP1;FAAP20;UBE2T
ruxolitinib Kinase inhibitor No MSN01 Up Fibrillar collagen core structure organization 6.06E-09 2 NaN COL11A2;COL1A1;COL1A2;COL2A1;COL3A1;COL5A2
ruxolitinib Kinase inhibitor No MSN02 Up Fibrillar collagen core structure organization 1.35E-06 4 NaN COL11A2;COL1A1;COL1A2;COL2A1;COL3A1
ruxolitinib Kinase inhibitor No MSN05 Up Fibrillar collagen core structure organization 2.75E-09 2 NaN COL11A1;COL1A1;COL1A2;COL2A1;COL3A1;COL5A1
ruxolitinib Kinase inhibitor No MSN06 Up Fibrillar collagen core structure organization 1.07E-08 2 NaN COL11A2;COL1A1;COL1A2;COL2A1;COL3A1;COL5A1
ruxolitinib Kinase inhibitor No MSN08 Up Fibrillar collagen core structure organization 2.32E-07 2 NaN COL11A1;COL1A1;COL1A2;COL2A1;COL3A1
ruxolitinib Kinase inhibitor No MSN09 Up Fibrillar collagen core structure organization 1.34E-10 1 NaN COL11A1;COL11A2;COL1A1;COL1A2;COL2A1;COL3A1;COL5A1
ruxolitinib Kinase inhibitor No MSN05 Up Fibrillin synthesis 0.046374785 16 NaN FBN1
ruxolitinib Kinase inhibitor No MSN08 Up Fibrillin synthesis 0.047143838 22 NaN FBN1
ruxolitinib Kinase inhibitor No MSN02 Up Fibulin receptor signaling 0.045002676 29.5 NaN FBLN1
ruxolitinib Kinase inhibitor No MSN06 Up Fibulin receptor signaling 0.038958404 22.5 NaN FBLN1
ruxolitinib Kinase inhibitor No MSN08 Up Fibulin receptor signaling 0.031680109 17 NaN FBLN1
ruxolitinib Kinase inhibitor No MSN09 Up Fibulin receptor signaling 0.039650143 22.5 NaN FBLN1
ruxolitinib Kinase inhibitor No MSN01 Up G2 M transition checkpoint 0.018715218 17 NaN CCNB1;CDK1
ruxolitinib Kinase inhibitor No MSN02 Up G2 M transition checkpoint 0.029300737 27 NaN CCNB1;CDK1
ruxolitinib Kinase inhibitor No MSN06 Up G2 M transition checkpoint 0.022330855 16.5 NaN CCNB1;CDK1
ruxolitinib Kinase inhibitor No MSN09 Up G2 M transition checkpoint 0.023086706 18 NaN CCNB1;CDK1
ruxolitinib Kinase inhibitor No MSN01 Up GABA metabolism 0.004565005 10 NaN ABAT;SLC6A1
ruxolitinib Kinase inhibitor No MSN05 Up GABA metabolism 0.003528251 4.5 NaN ABAT;SLC6A1
ruxolitinib Kinase inhibitor No MSN06 Up GABA metabolism 0.005485195 4 NaN ABAT;SLC6A1
ruxolitinib Kinase inhibitor No MSN08 Up GABA metabolism 0.003645933 5.5 NaN ABAT;SLC6A1
ruxolitinib Kinase inhibitor No MSN09 Up GABA metabolism 0.005678798 8.5 NaN ABAT;SLC6A1
ruxolitinib Kinase inhibitor No MSN01 Up Gap junction organization 0.025206934 19 NaN GJA1;GJA5
ruxolitinib Kinase inhibitor No MSN01 Down Glutamate and glutamine metabolism 0.005074033 6 NaN SLC1A5;SLC38A2;SLC7A5
ruxolitinib Kinase inhibitor No MSN02 Down Glutamate and glutamine metabolism 0.037334294 16.5 NaN SLC1A5;SLC7A5
ruxolitinib Kinase inhibitor No MSN05 Down Glutamate and glutamine metabolism 0.006165206 7 NaN SLC1A5;SLC38A2;SLC7A5
ruxolitinib Kinase inhibitor No MSN09 Down Glutamate and glutamine metabolism 0.045193362 17.5 NaN SLC1A5;SLC7A5
ruxolitinib Kinase inhibitor No MSN01 Down Granulocyte-colony stimulating factor receptor signaling 0.024789627 16 NaN SOCS3;STAT3
ruxolitinib Kinase inhibitor No MSN02 Down Granulocyte-colony stimulating factor receptor signaling 0.018346559 9 NaN SOCS3;STAT3
ruxolitinib Kinase inhibitor No MSN05 Down Granulocyte-colony stimulating factor receptor signaling 0.028241393 15 NaN SOCS3;STAT3
ruxolitinib Kinase inhibitor No MSN06 Down Granulocyte-colony stimulating factor receptor signaling 0.021531918 13 NaN SOCS3;STAT3
ruxolitinib Kinase inhibitor No MSN08 Down Granulocyte-colony stimulating factor receptor signaling 0.026868005 12 NaN SOCS3;STAT3
ruxolitinib Kinase inhibitor No MSN09 Down Granulocyte-colony stimulating factor receptor signaling 0.022362683 12 NaN SOCS3;STAT3
ruxolitinib Kinase inhibitor No MSN02 Down Heparin-binding EGF-like growth factor receptor signaling 0.001681304 5 NaN ADAM9;HBEGF
ruxolitinib Kinase inhibitor No MSN09 Down Heparin-binding EGF-like growth factor receptor signaling 0.002071198 4 NaN ADAM9;HBEGF
ruxolitinib Kinase inhibitor No MSN01 Down Hepatocyte growth factor receptor signaling 0.000784522 3 NaN HGF;MET
ruxolitinib Kinase inhibitor No MSN02 Down Hepatocyte growth factor receptor signaling 0.047242835 21 NaN HGF
ruxolitinib Kinase inhibitor No MSN05 Down Hepatocyte growth factor receptor signaling 0.000902302 3 NaN HGF;MET
ruxolitinib Kinase inhibitor No MSN08 Down Hepatocyte growth factor receptor signaling 0.000855234 4 NaN HGF;MET
ruxolitinib Kinase inhibitor No MSN02 Up Hyaluronan-mediated motility receptor signaling 0.022759351 23 NaN HMMR
ruxolitinib Kinase inhibitor No MSN08 Up Inhibition of amyloid aggregation, amyloid degradation and uptake 0.047143838 22 NaN PLAT
ruxolitinib Kinase inhibitor No MSN06 Up Inhibition of apoptosis 0.022330855 16.5 NaN BIRC5;IFI6
ruxolitinib Kinase inhibitor No MSN08 Up Inhibition of apoptosis 0.015062947 9 NaN BIRC5;IFI6
ruxolitinib Kinase inhibitor No MSN06 Up Integrin-mediated leukocyte rolling 0.007580082 6 NaN ICAM1;SELPLG
ruxolitinib Kinase inhibitor No MSN02 Down Interleukin 6 receptor signaling 0.047242835 21 NaN JAK3
ruxolitinib Kinase inhibitor No MSN02 Down Interleukin 7 receptor signaling 0.047242835 21 NaN JAK3
ruxolitinib Kinase inhibitor No MSN02 Up Intracellular bridge assembly 0.001524767 9 NaN INCENP;KIF23
ruxolitinib Kinase inhibitor No MSN02 Down JAK-STAT signaling pathway 0.042882493 18 NaN SOCS3;STAT3
ruxolitinib Kinase inhibitor No MSN06 Down JAK-STAT signaling pathway 0.005131546 5 NaN SOCS2;SOCS3;STAT3
ruxolitinib Kinase inhibitor No MSN09 Down JAK-STAT signaling pathway 0.005428272 6 NaN SOCS2;SOCS3;STAT3
ruxolitinib Kinase inhibitor No MSN01 Down Leptin receptor signaling 0.004533971 5 NaN SOCS3;STAT3
ruxolitinib Kinase inhibitor No MSN02 Down Leptin receptor signaling 0.003309507 6 NaN SOCS3;STAT3
ruxolitinib Kinase inhibitor No MSN05 Down Leptin receptor signaling 0.005200324 6 NaN SOCS3;STAT3
ruxolitinib Kinase inhibitor No MSN06 Down Leptin receptor signaling 0.003911609 3.5 NaN SOCS3;STAT3
ruxolitinib Kinase inhibitor No MSN08 Down Leptin receptor signaling 0.004934362 6 NaN SOCS3;STAT3
ruxolitinib Kinase inhibitor No MSN09 Down Leptin receptor signaling 0.004069701 5 NaN SOCS3;STAT3
ruxolitinib Kinase inhibitor No MSN02 Up Lipogenesis 0.045002676 29.5 NaN FASN
ruxolitinib Kinase inhibitor No MSN05 Up Lipogenesis 0.03115918 12.5 NaN FASN
ruxolitinib Kinase inhibitor No MSN06 Up Lipogenesis 0.038958404 22.5 NaN FASN
ruxolitinib Kinase inhibitor No MSN08 Up Lipogenesis 0.031680109 17 NaN FASN
ruxolitinib Kinase inhibitor No MSN09 Up Lipogenesis 0.039650143 22.5 NaN FASN
ruxolitinib Kinase inhibitor No MSN05 Up Lysine metabolism 0.046374785 16 NaN LOX
ruxolitinib Kinase inhibitor No MSN08 Up Lysine metabolism 0.047143838 22 NaN LOX
ruxolitinib Kinase inhibitor No MSN01 Up Metaphase to anaphase checkpoint 1.90E-06 3 NaN BUB1;BUB1B;CCNB2;CDC20;CENPE;MAD2L1;PTTG1
ruxolitinib Kinase inhibitor No MSN02 Up Metaphase to anaphase checkpoint 7.02E-07 3 NaN BUB1;BUB1B;CCNB2;CDC20;CENPE;MAD2L1;PTTG1;TTK
ruxolitinib Kinase inhibitor No MSN09 Up Metaphase to anaphase checkpoint 0.000533686 4 NaN BUB1;CCNB2;CDC20;CENPE;PTTG1
ruxolitinib Kinase inhibitor No MSN02 Down Methionine cycle 0.047242835 21 NaN BHMT
ruxolitinib Kinase inhibitor No MSN01 Up Microfibril scaffold organization 0.035495973 20.5 NaN FBN1
ruxolitinib Kinase inhibitor No MSN02 Up Microfibril scaffold organization 0.045002676 29.5 NaN FBN1
ruxolitinib Kinase inhibitor No MSN05 Up Microfibril scaffold organization 0.03115918 12.5 NaN FBN1
ruxolitinib Kinase inhibitor No MSN06 Up Microfibril scaffold organization 0.038958404 22.5 NaN FBN1
ruxolitinib Kinase inhibitor No MSN08 Up Microfibril scaffold organization 0.031680109 17 NaN FBN1
ruxolitinib Kinase inhibitor No MSN09 Up Microfibril scaffold organization 0.039650143 22.5 NaN FBN1
ruxolitinib Kinase inhibitor No MSN01 Down Microtubule crosslinking and bundling 0.010919862 11.5 NaN MAP2;MTCL1
ruxolitinib Kinase inhibitor No MSN02 Up Microtubule destabilization 0.007285832 14 NaN KIF2C;STMN1
ruxolitinib Kinase inhibitor No MSN09 Up Microtubule destabilization 0.005678798 8.5 NaN KIF2C;STMN1
ruxolitinib Kinase inhibitor No MSN01 Up Mitotic H3 phosphorylation and dephosphorylation 0.003079589 8 NaN AURKB;CCNA2
ruxolitinib Kinase inhibitor No MSN02 Up Mitotic H3 phosphorylation and dephosphorylation 0.000112656 5 NaN AURKB;CCNA2;INCENP
ruxolitinib Kinase inhibitor No MSN01 Up Mitotic spindle assembly 6.29E-05 5 NaN DLGAP5;NUSAP1;TACC3;TPX2
ruxolitinib Kinase inhibitor No MSN02 Up Mitotic spindle assembly 0.000159406 6 NaN DLGAP5;NUSAP1;TPX2;TTK
ruxolitinib Kinase inhibitor No MSN09 Up Mitotic spindle assembly 0.001953592 6 NaN DLGAP5;NUSAP1;TPX2
ruxolitinib Kinase inhibitor No MSN01 Up Mitotic spindle disassembly 0.017907551 15 NaN CDK1
ruxolitinib Kinase inhibitor No MSN02 Up Mitotic spindle disassembly 0.022759351 23 NaN CDK1
ruxolitinib Kinase inhibitor No MSN06 Up Mitotic spindle disassembly 0.019671842 13.5 NaN CDK1
ruxolitinib Kinase inhibitor No MSN09 Up Mitotic spindle disassembly 0.0200247 15 NaN CDK1
ruxolitinib Kinase inhibitor No MSN01 Down Natriuretic peptide receptor signaling 0.010919862 11.5 NaN NPPB;NPR3
ruxolitinib Kinase inhibitor No MSN06 Up Neuregulin receptor signaling 0.018850561 10.5 NaN ERBB3;SH3TC2
ruxolitinib Kinase inhibitor No MSN05 Down Notch receptor signaling 0.021041398 14 NaN JAG2;LFNG;NOTCH3
ruxolitinib Kinase inhibitor No MSN06 Down Notch receptor signaling 0.014324969 10 NaN DLK1;LFNG;NOTCH3
ruxolitinib Kinase inhibitor No MSN08 Down Notch receptor signaling 0.002413942 5 NaN DLK1;JAG2;LFNG;NOTCH3
ruxolitinib Kinase inhibitor No MSN09 Down Notch receptor signaling 0.015117884 10 NaN DLK1;LFNG;NOTCH3
ruxolitinib Kinase inhibitor No MSN02 Up Nuclear intermediate filaments 0.007285832 14 NaN LMNB1;LMNB2
ruxolitinib Kinase inhibitor No MSN02 Up Nucleosome assembly 0.001387858 8 NaN ASF1B;H2AFZ;HIST1H1C;TSPYL2
ruxolitinib Kinase inhibitor No MSN01 Down Oncostatin-M receptor signaling 0.00741681 8.5 NaN OSMR;STAT3
ruxolitinib Kinase inhibitor No MSN05 Down Oncostatin-M receptor signaling 0.008495241 9 NaN OSMR;STAT3
ruxolitinib Kinase inhibitor No MSN06 Down Osteonectin receptor signaling 0.003911609 3.5 NaN SMOC2;SPOCK1
ruxolitinib Kinase inhibitor No MSN05 Up Osteopontin receptor signaling 0.015702188 7.5 NaN SPP1
ruxolitinib Kinase inhibitor No MSN08 Up Osteopontin receptor signaling 0.015966831 11.5 NaN SPP1
ruxolitinib Kinase inhibitor No MSN09 Up Osteopontin receptor signaling 0.0200247 15 NaN SPP1
ruxolitinib Kinase inhibitor No MSN06 Down Potassium transmembrane transport 0.023568011 14 NaN ATP1A3;KCNE4;KCNQ1
ruxolitinib Kinase inhibitor No MSN08 Down Potassium transmembrane transport 0.03196174 16 NaN ATP1A3;KCNE4;KCNQ1
ruxolitinib Kinase inhibitor No MSN02 Down Progesterone receptor signaling 0.02390614 13 NaN PGR
ruxolitinib Kinase inhibitor No MSN06 Down Progesterone receptor signaling 0.026023289 15.5 NaN PGR
ruxolitinib Kinase inhibitor No MSN08 Down Progesterone receptor signaling 0.029287227 14 NaN PGR
ruxolitinib Kinase inhibitor No MSN09 Down Progesterone receptor signaling 0.026552576 14 NaN PGR
ruxolitinib Kinase inhibitor No MSN05 Down Prostaglandin E2 receptor signaling 0.012490666 11.5 NaN PTGER3;RAPGEF4
ruxolitinib Kinase inhibitor No MSN09 Up Protein polyubiquitination 0.039837635 25 NaN ISG15;UBE2S
ruxolitinib Kinase inhibitor No MSN02 Down Recycling endosome dynamics 0.028486074 15 NaN RAB15;S100A10;SNAP23
ruxolitinib Kinase inhibitor No MSN06 Down Recycling endosome dynamics 0.035364453 19 NaN EHD3;RAB15;S100A10
ruxolitinib Kinase inhibitor No MSN01 Down Retinoic acid receptor signaling 0.049902543 20.5 NaN NR4A1;TBL1XR1
ruxolitinib Kinase inhibitor No MSN02 Down Retinoic acid receptor signaling 0.037334294 16.5 NaN NR4A1;TBL1XR1
ruxolitinib Kinase inhibitor No MSN06 Down Retinoic acid receptor signaling 0.043574597 20 NaN NR4A1;TBL1XR1
ruxolitinib Kinase inhibitor No MSN09 Down Retinoic acid receptor signaling 0.045193362 17.5 NaN NR4A1;TBL1XR1
ruxolitinib Kinase inhibitor No MSN01 Up Retinol metabolism 0.021860273 18 NaN ALDH1A1;ALDH1A2
ruxolitinib Kinase inhibitor No MSN05 Up Retinol metabolism 0.017068908 10 NaN ALDH1A1;RDH10
ruxolitinib Kinase inhibitor No MSN06 Up Retinol metabolism 0.026053443 18 NaN ALDH1A2;RDH10
ruxolitinib Kinase inhibitor No MSN08 Up Retinol metabolism 0.001017685 4 NaN ALDH1A1;RDH10;TTR
ruxolitinib Kinase inhibitor No MSN09 Up Retinol metabolism 0.026929091 19 NaN ALDH1A1;RDH10
ruxolitinib Kinase inhibitor No MSN01 Down Sarcoplasmic reticulum organization 0.019640794 15 NaN PLN;TRDN
ruxolitinib Kinase inhibitor No MSN06 Down Sarcoplasmic reticulum organization 0.017036884 11.5 NaN PLN;TRDN
ruxolitinib Kinase inhibitor No MSN08 Down Sarcoplasmic reticulum organization 0.021304837 11 NaN PLN;TRDN
ruxolitinib Kinase inhibitor No MSN06 Up Selectin-mediated Leukocyte rolling 0.005485195 4 NaN ICAM1;SELPLG
ruxolitinib Kinase inhibitor No MSN08 Up Semaphorin signaling 0.016664642 14 NaN DPYSL4;NRP2;SEMA6D
ruxolitinib Kinase inhibitor No MSN01 Down Serine and glycine metabolism 0.000171562 2 NaN PHGDH;PSAT1;SHMT2;SLC1A5
ruxolitinib Kinase inhibitor No MSN02 Down Serine and glycine metabolism 9.23E-05 2 NaN PHGDH;PSAT1;SHMT2;SLC1A5
ruxolitinib Kinase inhibitor No MSN05 Down Serine and glycine metabolism 0.000224525 1 NaN PHGDH;PSAT1;SHMT2;SLC1A5
ruxolitinib Kinase inhibitor No MSN06 Down Serine and glycine metabolism 0.002464684 2 NaN PHGDH;PSAT1;SHMT2
ruxolitinib Kinase inhibitor No MSN08 Down Serine and glycine metabolism 0.000202562 3 NaN PHGDH;PSAT1;SHMT2;SLC1A5
ruxolitinib Kinase inhibitor No MSN09 Down Serine and glycine metabolism 0.000138746 3 NaN PHGDH;PSAT1;SHMT2;SLC1A5
ruxolitinib Kinase inhibitor No MSN02 Down Serotonin inactivation 0.047242835 21 NaN MAOA
ruxolitinib Kinase inhibitor No MSN01 Up Sister chromatid attachment to mitotic spindle 0.035495973 20.5 NaN TACC3
ruxolitinib Kinase inhibitor No MSN02 Up Sister chromatid attachment to mitotic spindle 0.045002676 29.5 NaN NUF2
ruxolitinib Kinase inhibitor No MSN06 Up Sister chromatid attachment to mitotic spindle 0.038958404 22.5 NaN NUF2
ruxolitinib Kinase inhibitor No MSN09 Up Sister chromatid attachment to mitotic spindle 0.039650143 22.5 NaN NUF2
ruxolitinib Kinase inhibitor No MSN01 Up Sister chromatid segregation 0.004565005 10 NaN ESPL1;PTTG1
ruxolitinib Kinase inhibitor No MSN02 Up Sister chromatid segregation 0.000221517 7 NaN ESPL1;PTTG1;TOP2A
ruxolitinib Kinase inhibitor No MSN01 Down Thin myofilament organization 0.015006283 14 NaN ACTA1;TNNI3
ruxolitinib Kinase inhibitor No MSN02 Down Thin myofilament organization 0.000440408 3 NaN ACTA1;NEBL;TNNI3
ruxolitinib Kinase inhibitor No MSN05 Down Thin myofilament organization 0.017141721 13 NaN ACTA1;TNNI3
ruxolitinib Kinase inhibitor No MSN06 Down Thin myofilament organization 0.012999296 9 NaN ACTA1;TNNI3
ruxolitinib Kinase inhibitor No MSN08 Down Thin myofilament organization 0.016291005 9.5 NaN ACTA1;TNNI3
ruxolitinib Kinase inhibitor No MSN09 Down Thin myofilament organization 0.013510309 9 NaN ACTA1;TNNI3
ruxolitinib Kinase inhibitor No MSN01 Down Tropoelastin synthesis 0.028052223 17.5 NaN ELN
ruxolitinib Kinase inhibitor No MSN02 Down Tropoelastin synthesis 0.02390614 13 NaN ELN
ruxolitinib Kinase inhibitor No MSN05 Down Tropoelastin synthesis 0.030081157 16.5 NaN ELN
ruxolitinib Kinase inhibitor No MSN08 Down Tropoelastin synthesis 0.029287227 14 NaN ELN
ruxolitinib Kinase inhibitor No MSN09 Down Tropoelastin synthesis 0.026552576 14 NaN ELN
ruxolitinib Kinase inhibitor No MSN05 Down Urea cycle 0.012490666 11.5 NaN ARG2;ASS1
ruxolitinib Kinase inhibitor No MSN06 Down Urea cycle 0.009446625 8 NaN ARG2;ASS1
ruxolitinib Kinase inhibitor No MSN08 Down Urea cycle 0.011864496 8 NaN ARG2;ASS1
ruxolitinib Kinase inhibitor No MSN09 Down Urea cycle 0.009821443 7.5 NaN ARG2;ASS1
ruxolitinib Kinase inhibitor No MSN01 Up Vascular endothelial growth factor receptor signaling 0.006315881 13 NaN FLT1;KDR
ruxolitinib Kinase inhibitor No MSN01 Up WNT-Beta-catenin signaling pathway 0.005681554 12 NaN APCDD1;DACT1;FRZB;SFRP2;SFRP5
ruxolitinib Kinase inhibitor No MSN02 Up WNT-Beta-catenin signaling pathway 0.015045373 18 NaN APCDD1;DKK2;FRZB;SFRP2;SFRP5
ruxolitinib Kinase inhibitor No MSN05 Up WNT-Beta-catenin signaling pathway 0.017982282 11 NaN APCDD1;FRZB;SFRP2;SFRP5
ruxolitinib Kinase inhibitor No MSN06 Up WNT-Beta-catenin signaling pathway 0.037023388 20 NaN APCDD1;FRZB;SFRP2;SFRP5
ruxolitinib Kinase inhibitor No MSN09 Up WNT-Beta-catenin signaling pathway 0.039120547 20 NaN APCDD1;FRZB;SFRP2;SFRP5
ruxolitinib Kinase inhibitor No MSN01 Down Z-disc organization 5.70E-05 1 NaN CSRP3;DES;LDB3;PDLIM3;TCAP
ruxolitinib Kinase inhibitor No MSN02 Down Z-disc organization 1.16E-06 1 NaN CSRP3;DES;LDB3;NEBL;PDLIM3;TCAP
ruxolitinib Kinase inhibitor No MSN05 Down Z-disc organization 0.001098997 4 NaN CSRP3;DES;PDLIM3;TCAP
ruxolitinib Kinase inhibitor No MSN06 Down Z-disc organization 0.00759691 7 NaN CSRP3;DES;LDB3
ruxolitinib Kinase inhibitor No MSN08 Down Z-disc organization 7.00E-05 1 NaN CSRP3;DES;LDB3;PDLIM3;TCAP
ruxolitinib Kinase inhibitor No MSN09 Down Z-disc organization 4.38E-05 1 NaN CSRP3;DES;LDB3;PDLIM3;TCAP
ruxolitinib Kinase inhibitor No MSN09 Up Acetylcholine-mediated control of postsynaptic potential 0.007845779 12 NaN AGRN;CHRNA1
ruxolitinib Kinase inhibitor No MSN01 Down Actin polymerization 0.006114931 7 NaN ABRA;ACTA1;ENAH;FMNL2;GAS7
ruxolitinib Kinase inhibitor No MSN08 Up Acute-phase response 0.047143838 22 NaN TTR
ruxolitinib Kinase inhibitor No MSN01 Down Aggrecan synthesis 0.028052223 17.5 NaN ACAN
ruxolitinib Kinase inhibitor No MSN02 Down Aggrecan synthesis 0.02390614 13 NaN ACAN
ruxolitinib Kinase inhibitor No MSN05 Down Aggrecan synthesis 0.030081157 16.5 NaN ACAN
ruxolitinib Kinase inhibitor No MSN06 Down Aggrecan synthesis 0.026023289 15.5 NaN ACAN
ruxolitinib Kinase inhibitor No MSN08 Down Aggrecan synthesis 0.029287227 14 NaN ACAN
ruxolitinib Kinase inhibitor No MSN09 Down Aggrecan synthesis 0.026552576 14 NaN ACAN
ruxolitinib Kinase inhibitor No MSN01 Up Albumin mediated blood protein transport 0.017907551 15 NaN ALB
ruxolitinib Kinase inhibitor No MSN02 Up Albumin mediated blood protein transport 0.022759351 23 NaN ALB
ruxolitinib Kinase inhibitor No MSN05 Up Albumin mediated blood protein transport 0.015702188 7.5 NaN ALB
ruxolitinib Kinase inhibitor No MSN06 Up Albumin mediated blood protein transport 0.019671842 13.5 NaN ALB
ruxolitinib Kinase inhibitor No MSN08 Up Albumin mediated blood protein transport 0.015966831 11.5 NaN ALB
ruxolitinib Kinase inhibitor No MSN09 Up Albumin mediated blood protein transport 0.0200247 15 NaN ALB
ruxolitinib Kinase inhibitor No MSN05 Down Alternative complement pathway 0.008495241 9 NaN C3;CFH
ruxolitinib Kinase inhibitor No MSN06 Up Amyloid plaque organization 0.018850561 10.5 NaN SLC30A3;SNCA
ruxolitinib Kinase inhibitor No MSN01 Down Antigen presentation via MHC class I molecules 0.030420468 19 NaN HLA-B;HLA-C
ruxolitinib Kinase inhibitor No MSN02 Down Antigen presentation via MHC class I molecules 0.022575326 10.5 NaN HLA-B;HLA-C
ruxolitinib Kinase inhibitor No MSN05 Down Antigen presentation via MHC class I molecules 0.034610193 18 NaN HLA-B;HLA-C
ruxolitinib Kinase inhibitor No MSN06 Down Antigen presentation via MHC class I molecules 0.026458023 17.5 NaN HLA-B;HLA-C
ruxolitinib Kinase inhibitor No MSN08 Down Antigen presentation via MHC class I molecules 0.032944232 17 NaN HLA-B;HLA-C
ruxolitinib Kinase inhibitor No MSN09 Down Antigen presentation via MHC class I molecules 0.027469295 16 NaN HLA-B;HLA-C
ruxolitinib Kinase inhibitor No MSN01 Down Aspartate and arginine metabolism 0.002266266 4 NaN ARG2;SLC7A1;SLC7A2
ruxolitinib Kinase inhibitor No MSN02 Down Aspartate and arginine metabolism 0.00143149 4 NaN ARG2;SLC7A1;SLC7A2
ruxolitinib Kinase inhibitor No MSN05 Down Aspartate and arginine metabolism 0.002766197 5 NaN ARG2;ASS1;SLC7A2
ruxolitinib Kinase inhibitor No MSN06 Down Aspartate and arginine metabolism 0.0018275 1 NaN ARG2;ASS1;SLC7A1
ruxolitinib Kinase inhibitor No MSN08 Down Aspartate and arginine metabolism 0.000131941 2 NaN ARG2;ASS1;SLC7A1;SLC7A2
ruxolitinib Kinase inhibitor No MSN09 Down Aspartate and arginine metabolism 9.02E-05 2 NaN ARG2;ASS1;SLC7A1;SLC7A2
ruxolitinib Kinase inhibitor No MSN02 Up Axonal intermediate filament dynamics 0.010047711 17 NaN NEFH;NEFM
ruxolitinib Kinase inhibitor No MSN02 Up Biglycan synthesis 0.022759351 23 NaN BGN
ruxolitinib Kinase inhibitor No MSN06 Up Biglycan synthesis 0.019671842 13.5 NaN BGN
ruxolitinib Kinase inhibitor No MSN08 Up Biglycan synthesis 0.015966831 11.5 NaN BGN
ruxolitinib Kinase inhibitor No MSN09 Up Biglycan synthesis 0.0200247 15 NaN BGN
ruxolitinib Kinase inhibitor No MSN05 Up Cardiomyocyte depolarization during action potential 0.015702188 7.5 NaN SCN5A
ruxolitinib Kinase inhibitor No MSN06 Up Cardiomyocyte repolarization during action potential and hyperpolarization 0.030007535 19 NaN KCNIP2;KCNQ5
ruxolitinib Kinase inhibitor No MSN06 Down Cardiomyocyte repolarization during action potential and hyperpolarization 0.049981772 21 NaN KCNJ12;KCNQ1
ruxolitinib Kinase inhibitor No MSN01 Down CCN intercellular signaling protein family receptor signaling 0.00741681 8.5 NaN CYR61;NOV
ruxolitinib Kinase inhibitor No MSN06 Down CCN intercellular signaling protein family receptor signaling 0.006407471 6 NaN CTGF;NOV
ruxolitinib Kinase inhibitor No MSN02 Up Cell cycle arrest in response to DNA damage 0.016567078 19 NaN H2AFX;MDM2;UHRF1
ruxolitinib Kinase inhibitor No MSN05 Up Cellular iron storage 0.046374785 16 NaN FTL
ruxolitinib Kinase inhibitor No MSN08 Up Cellular iron storage 0.047143838 22 NaN FTL
ruxolitinib Kinase inhibitor No MSN08 Up Cellular iron uptake and export 0.017616631 15 NaN CD163;RASD1
ruxolitinib Kinase inhibitor No MSN01 Up Centrosome maturation 0.001104833 7 NaN AURKA;PLK1;TPX2
ruxolitinib Kinase inhibitor No MSN02 Up Centrosome maturation 0.002201501 10 NaN AURKA;PLK1;TPX2
ruxolitinib Kinase inhibitor No MSN09 Up Centrosome maturation 0.001525179 5 NaN AURKA;PLK1;TPX2
ruxolitinib Kinase inhibitor No MSN01 Up Centrosome separation 6.11E-11 1 NaN AURKA;CCNB1;CDK1;ESPL1;KIF11;NEK2;SPAG5
ruxolitinib Kinase inhibitor No MSN02 Up Centrosome separation 3.30E-10 1 NaN AURKA;CCNB1;CDK1;ESPL1;KIF11;NEK2;SPAG5
ruxolitinib Kinase inhibitor No MSN06 Up Centrosome separation 0.015623688 9 NaN CCNB1;CDK1
ruxolitinib Kinase inhibitor No MSN09 Up Centrosome separation 7.16E-07 3 NaN AURKA;CCNB1;CDK1;NEK2;SPAG5
ruxolitinib Kinase inhibitor No MSN01 Down Chloride transmembrane transport 0.049902543 20.5 NaN ANO1;BEST1
ruxolitinib Kinase inhibitor No MSN02 Up Cholesterol synthesis 0.009974492 16 NaN DHCR24;FDPS;HMGCS1
ruxolitinib Kinase inhibitor No MSN05 Up Cholesterol synthesis 3.39E-10 1 NaN DHCR24;DHCR7;FDFT1;FDPS;HMGCR;HMGCS1;MSMO1;MVK
ruxolitinib Kinase inhibitor No MSN06 Up Cholesterol synthesis 2.03E-09 1 NaN DHCR24;DHCR7;FDFT1;FDPS;HMGCR;HMGCS1;MSMO1;MVD
ruxolitinib Kinase inhibitor No MSN08 Up Cholesterol synthesis 1.53E-08 1 NaN DHCR7;FDFT1;FDPS;HMGCS1;MSMO1;MVD;MVK
ruxolitinib Kinase inhibitor No MSN09 Up Cholesterol synthesis 2.34E-09 2 NaN DHCR24;DHCR7;FDFT1;FDPS;HMGCR;HMGCS1;MVD;MVK
ruxolitinib Kinase inhibitor No MSN01 Down Cholesterol-sensitive control of SREBP activation 0.010919862 11.5 NaN INSIG1;SREBF1
ruxolitinib Kinase inhibitor No MSN08 Up Classical complement pathway 0.005050837 7 NaN C1QB;C1QC
ruxolitinib Kinase inhibitor No MSN05 Down Classical complement pathway 0.000863028 2 NaN C1QA;C1R;C4A
ruxolitinib Kinase inhibitor No MSN08 Down Classical complement pathway 0.016291005 9.5 NaN C1QA;C1R
ruxolitinib Kinase inhibitor No MSN01 Up Collagen fibril organization by fibril-associated bridges 0.004565005 10 NaN COL14A1;COL9A1
ruxolitinib Kinase inhibitor No MSN02 Up Collagen fibril organization by fibril-associated bridges 0.007285832 14 NaN COL14A1;COL9A1
ruxolitinib Kinase inhibitor No MSN05 Up Collagen fibril organization by fibril-associated bridges 0.003528251 4.5 NaN COL14A1;COL9A1
ruxolitinib Kinase inhibitor No MSN06 Up Collagen fibril organization by fibril-associated bridges 0.005485195 4 NaN COL14A1;COL9A1
ruxolitinib Kinase inhibitor No MSN08 Up Collagen fibril organization by fibril-associated bridges 0.003645933 5.5 NaN COL14A1;COL9A1
ruxolitinib Kinase inhibitor No MSN09 Up Collagen fibril organization by fibril-associated bridges 0.005678798 8.5 NaN COL14A1;COL9A1
ruxolitinib Kinase inhibitor No MSN01 Down Collagen fibril organization by fibril-associated bridges 0.010919862 11.5 NaN COL12A1;COL9A2
ruxolitinib Kinase inhibitor No MSN02 Down Collagen fibril organization by fibril-associated bridges 0.00801527 7 NaN COL12A1;COL9A2
ruxolitinib Kinase inhibitor No MSN09 Down Collagen fibril organization by fibril-associated bridges 0.009821443 7.5 NaN COL12A1;COL9A2
ruxolitinib Kinase inhibitor No MSN09 Up Connection of muscle sarcomere to extracellular matrix 0.005678798 8.5 NaN AGRN;SGCD
ruxolitinib Kinase inhibitor No MSN02 Down Connection of muscle sarcomere to plasma membrane 0.022575326 10.5 NaN DES;SYNM
ruxolitinib Kinase inhibitor No MSN06 Down Connection of muscle sarcomere to plasma membrane 0.026458023 17.5 NaN DES;SYNM
ruxolitinib Kinase inhibitor No MSN01 Up Decorin synthesis 0.017907551 15 NaN DCN
ruxolitinib Kinase inhibitor No MSN02 Up Decorin synthesis 0.022759351 23 NaN DCN
ruxolitinib Kinase inhibitor No MSN05 Up Decorin synthesis 0.015702188 7.5 NaN DCN
ruxolitinib Kinase inhibitor No MSN06 Up Decorin synthesis 0.019671842 13.5 NaN DCN
ruxolitinib Kinase inhibitor No MSN08 Up Decorin synthesis 0.015966831 11.5 NaN DCN
ruxolitinib Kinase inhibitor No MSN09 Up Decorin synthesis 0.0200247 15 NaN DCN
ruxolitinib Kinase inhibitor No MSN02 Up DNA cleavage 0.024784198 26 NaN FEN1;HMGB2
ruxolitinib Kinase inhibitor No MSN02 Up DNA replication elongation 0.00493106 12 NaN MCM2;PCNA
ruxolitinib Kinase inhibitor No MSN02 Up DNA replication initiation 0.002274944 11 NaN CDC45;CDC6;GINS2;MCM2
ruxolitinib Kinase inhibitor No MSN05 Up Elastin cross-linking and assembly 0.046374785 16 NaN LOX
ruxolitinib Kinase inhibitor No MSN08 Up Elastin cross-linking and assembly 0.047143838 22 NaN LOX
ruxolitinib Kinase inhibitor No MSN05 Down Endogenous control of complement activity 0.008495241 9 NaN CFH;CFI
ruxolitinib Kinase inhibitor No MSN08 Down Endogenous control of complement activity 0.008065076 7 NaN CFH;CFI
ruxolitinib Kinase inhibitor No MSN05 Up Ephrin receptor signaling 0.046374785 16 NaN EPHA2
ruxolitinib Kinase inhibitor No MSN08 Up Ephrin receptor signaling 0.047143838 22 NaN EPHA2
rosiglitazone Antidiabetic No MSN01 Down Actin filament severing and depolymerization 0.024127969 17.5 NaN LIMA1;TAGLN2
rosiglitazone Antidiabetic No MSN01 Down Adherens junction organization 0.041831268 23 NaN CDH1;CGNL1;MYO1D
rosiglitazone Antidiabetic No MSN02 Down Adherens junction organization 0.010590543 8 NaN CDH1;CDH3;CGNL1;MYO1D
rosiglitazone Antidiabetic No MSN08 Down Adherens junction organization 0.007599392 6 NaN CDH1;CDH3;CGNL1;MYO1D
rosiglitazone Antidiabetic No MSN05 Down Aggrecan synthesis 0.016055046 11 NaN ACAN
rosiglitazone Antidiabetic No MSN09 Down Aggrecan synthesis 0.020377558 14 NaN ACAN
rosiglitazone Antidiabetic No MSN01 Down Albumin mediated blood protein transport 0.018877911 14.5 NaN ALB
rosiglitazone Antidiabetic No MSN02 Down Albumin mediated blood protein transport 0.021083275 12.5 NaN ALB
rosiglitazone Antidiabetic No MSN05 Down Albumin mediated blood protein transport 0.016055046 11 NaN ALB
rosiglitazone Antidiabetic No MSN08 Down Albumin mediated blood protein transport 0.019142555 11.5 NaN ALB
rosiglitazone Antidiabetic No MSN09 Down Albumin mediated blood protein transport 0.020377558 14 NaN ALB
rosiglitazone Antidiabetic No MSN01 Up Alternative complement pathway 0.006365168 8.5 NaN C3;CFH
rosiglitazone Antidiabetic No MSN02 Up Alternative complement pathway 0.005666345 5.5 NaN C3;CFH
rosiglitazone Antidiabetic No MSN05 Up Alternative complement pathway 0.000240425 4 NaN C1S;C3;CFH
rosiglitazone Antidiabetic No MSN08 Up Alternative complement pathway 0.006072761 9.5 NaN C3;CFH
rosiglitazone Antidiabetic No MSN09 Up Alternative complement pathway 0.005350837 5 NaN C3;CFH
rosiglitazone Antidiabetic No MSN05 Up Amyloid plaque organization 0.039716535 20 NaN APOE;SLC30A3
rosiglitazone Antidiabetic No MSN01 Down Amyloid plaque organization 0.000978687 2 NaN APOE;COL25A1;HSPB6
rosiglitazone Antidiabetic No MSN02 Down Amyloid plaque organization 0.02147651 15.5 NaN APOE;COL25A1
rosiglitazone Antidiabetic No MSN09 Down Amyloid plaque organization 0.020145007 11 NaN COL25A1;HSPB6
rosiglitazone Antidiabetic No MSN02 Up Androgen receptor signaling 0.048275867 19.5 NaN AR
rosiglitazone Antidiabetic No MSN08 Up Androgen receptor signaling 0.049996342 28.5 NaN AR
rosiglitazone Antidiabetic No MSN02 Up Antigen presentation via MHC class I molecules 0.00152477 2.5 NaN HLA-A;HLA-B;HLA-C
rosiglitazone Antidiabetic No MSN01 Up Aspartate and arginine metabolism 0.001809764 4.5 NaN ASS1;DDAH1;SLC7A1
rosiglitazone Antidiabetic No MSN05 Up Aspartate and arginine metabolism 0.033127671 19 NaN ARG2;ASS1
rosiglitazone Antidiabetic No MSN09 Up Aspartate and arginine metabolism 0.022263706 11 NaN ARG2;SLC7A1
rosiglitazone Antidiabetic No MSN01 Up Axonal intermediate filament dynamics 0.012914996 11.5 NaN NEFH;NEFM
rosiglitazone Antidiabetic No MSN09 Up Axonal intermediate filament dynamics 0.01088894 8 NaN NEFH;NEFM
rosiglitazone Antidiabetic No MSN09 Up Biglycan synthesis 0.023729711 13 NaN BGN
rosiglitazone Antidiabetic No MSN01 Down Biglycan synthesis 0.018877911 14.5 NaN BGN
rosiglitazone Antidiabetic No MSN02 Down Biglycan synthesis 0.021083275 12.5 NaN BGN
rosiglitazone Antidiabetic No MSN05 Down Biglycan synthesis 0.016055046 11 NaN BGN
rosiglitazone Antidiabetic No MSN08 Down Biglycan synthesis 0.019142555 11.5 NaN BGN
rosiglitazone Antidiabetic No MSN01 Up Cardiomyocyte pacemaker current generation 0.01692739 14 NaN CACNA1G;KCNK2
rosiglitazone Antidiabetic No MSN01 Up Cardiomyocyte repolarization during action potential and hyperpolarization 0.049677703 23.5 NaN KCNIP2;KCNJ2
rosiglitazone Antidiabetic No MSN09 Up Cardiomyocyte repolarization during action potential and hyperpolarization 0.042309999 18.5 NaN KCNA1;KCNIP2
rosiglitazone Antidiabetic No MSN05 Down Carnitine shuttle 0.005105448 4.5 NaN CPT1A;SLC25A20
rosiglitazone Antidiabetic No MSN09 Up CCN intercellular signaling protein family receptor signaling 0.005350837 5 NaN CTGF;CYR61
rosiglitazone Antidiabetic No MSN02 Down CCN intercellular signaling protein family receptor signaling 0.004244577 4 NaN NOV;WISP1
rosiglitazone Antidiabetic No MSN02 Down CD44-Mediated leukocyte rolling 0.041723865 19 NaN CD44
rosiglitazone Antidiabetic No MSN01 Down Cellular cholesterol uptake and efflux 0.024127969 17.5 NaN ABCA1;ABCG1
rosiglitazone Antidiabetic No MSN02 Down Cellular cholesterol uptake and efflux 0.029628054 17 NaN ABCA1;SCARA3
rosiglitazone Antidiabetic No MSN08 Down Cellular cholesterol uptake and efflux 0.02476286 14 NaN ABCA1;ABCG1
rosiglitazone Antidiabetic No MSN09 Down Cellular cholesterol uptake and efflux 0.027816815 18 NaN ABCA1;SCARA3
rosiglitazone Antidiabetic No MSN09 Up Cellular fatty acid uptake 0.046898366 21.5 NaN CD36
rosiglitazone Antidiabetic No MSN08 Up Cellular iron uptake and export 0.041452288 24 NaN CP;TFRC
rosiglitazone Antidiabetic No MSN09 Up Cellular iron uptake and export 0.036831666 16 NaN CP;TFRC
rosiglitazone Antidiabetic No MSN05 Up Cholesterol synthesis 6.20E-16 1 NaN CYP51A1;DHCR24;DHCR7;FDFT1;FDPS;HMGCR;HMGCS1;LSS;MSMO1;MVD;NSDHL;SC5D;SQLE
rosiglitazone Antidiabetic No MSN02 Down Cholesterol synthesis 0.000715545 1 NaN HMGCS1;MSMO1;MVD;MVK
rosiglitazone Antidiabetic No MSN05 Up Cholesterol-sensitive control of SREBP activation 0.011933343 13 NaN INSIG1;SREBF1
rosiglitazone Antidiabetic No MSN05 Up Classical complement pathway 0.016384575 15 NaN C1R;C1S
rosiglitazone Antidiabetic No MSN01 Down Classical complement pathway 0.006997877 7 NaN C1QB;C1QC
rosiglitazone Antidiabetic No MSN05 Down Classical complement pathway 0.005105448 4.5 NaN C1QA;C1QC
rosiglitazone Antidiabetic No MSN01 Up Collagen fiber crosslinking 0.006365168 8.5 NaN LOXL1;PXDN
rosiglitazone Antidiabetic No MSN05 Up Collagen fiber crosslinking 0.008112355 9.5 NaN LOXL1;PXDN
rosiglitazone Antidiabetic No MSN09 Up Collagen fiber crosslinking 0.005350837 5 NaN LOXL1;PXDN
rosiglitazone Antidiabetic No MSN05 Up Collagen fibril organization by fibril-associated bridges 0.011933343 13 NaN COL14A1;COL9A3
rosiglitazone Antidiabetic No MSN08 Up Collagen fibril organization by fibril-associated bridges 0.008957388 11.5 NaN COL9A2;COL9A3
rosiglitazone Antidiabetic No MSN01 Down Collagen fibril organization by fibril-associated bridges 0.005061213 4.5 NaN COL12A1;COL14A1
rosiglitazone Antidiabetic No MSN02 Down Collagen fibril organization by fibril-associated bridges 0.006278564 5 NaN COL12A1;COL14A1
rosiglitazone Antidiabetic No MSN08 Down Collagen fibril organization by fibril-associated bridges 0.005200747 3.5 NaN COL12A1;COL14A1
rosiglitazone Antidiabetic No MSN09 Down Collagen fibril organization by fibril-associated bridges 0.005875567 5 NaN COL14A1;COL9A2
rosiglitazone Antidiabetic No MSN01 Up Contractile ring constriction 0.006365168 8.5 NaN MYH14;MYLK
rosiglitazone Antidiabetic No MSN05 Up Contractile ring constriction 0.008112355 9.5 NaN MYH14;MYLK
rosiglitazone Antidiabetic No MSN02 Up Decorin synthesis 0.024435427 13.5 NaN DCN
rosiglitazone Antidiabetic No MSN08 Up Decorin synthesis 0.025317572 20.5 NaN DCN
rosiglitazone Antidiabetic No MSN05 Down Decorin synthesis 0.016055046 11 NaN DCN
rosiglitazone Antidiabetic No MSN05 Up Desaturation of fatty acids 2.39E-05 2 NaN FADS1;FADS2;SCD;SCD5
rosiglitazone Antidiabetic No MSN01 Up DNA replication initiation 0.02604878 19 NaN CDC45;GINS2;MCM7
rosiglitazone Antidiabetic No MSN02 Up DNA replication initiation 0.022313229 11 NaN CDC45;CDC6;MCM5
rosiglitazone Antidiabetic No MSN08 Up DNA replication initiation 0.003344472 5 NaN CDC45;CDC6;MCM5;MCM6
rosiglitazone Antidiabetic No MSN05 Down Elastin cross-linking and assembly 0.047400097 21 NaN LOX
rosiglitazone Antidiabetic No MSN01 Up Endogenous control of complement activity 0.006365168 8.5 NaN CFH;CFI
rosiglitazone Antidiabetic No MSN02 Up Endogenous control of complement activity 0.005666345 5.5 NaN CFH;CFI
rosiglitazone Antidiabetic No MSN05 Up Endogenous control of complement activity 0.008112355 9.5 NaN CFH;CFI
rosiglitazone Antidiabetic No MSN08 Up Endogenous control of complement activity 0.006072761 9.5 NaN CFH;CFI
rosiglitazone Antidiabetic No MSN01 Down Endothelin receptor signaling 0.006997877 7 NaN ECE1;EDN1
rosiglitazone Antidiabetic No MSN02 Down Endothelin receptor signaling 0.008668292 6.5 NaN ECE1;EDN1
rosiglitazone Antidiabetic No MSN05 Up Epithelial intermediate filament dynamics 0.021425951 16.5 NaN KRT19;KRT7
rosiglitazone Antidiabetic No MSN01 Down Epithelial intermediate filament dynamics 0.000346395 1 NaN KRT19;KRT4;KRT7
rosiglitazone Antidiabetic No MSN02 Down Epithelial intermediate filament dynamics 0.011397983 9 NaN KRT19;KRT7
rosiglitazone Antidiabetic No MSN09 Down Epithelial intermediate filament dynamics 0.010676413 7.5 NaN KRT19;KRT7
rosiglitazone Antidiabetic No MSN01 Up Natriuretic peptide receptor signaling 0.000325881 1 NaN NPPA;NPPB;NPR1
rosiglitazone Antidiabetic No MSN08 Up Natriuretic peptide receptor signaling 0.008957388 11.5 NaN NPPA;NPPB
rosiglitazone Antidiabetic No MSN09 Up Natriuretic peptide receptor signaling 0.007900936 7 NaN NPPA;NPPB
rosiglitazone Antidiabetic No MSN01 Up Notch receptor signaling 0.001546422 3 NaN DLK1;JAG1;LFNG;NOTCH3
rosiglitazone Antidiabetic No MSN02 Up Notch receptor signaling 0.012093552 7 NaN DLK1;JAG1;LFNG
rosiglitazone Antidiabetic No MSN08 Up Notch receptor signaling 0.013306061 14 NaN DLK1;JAG1;LFNG
rosiglitazone Antidiabetic No MSN09 Up Notch receptor signaling 0.01117202 9 NaN DLK1;LFNG;NOTCH3
rosiglitazone Antidiabetic No MSN09 Down Osteonectin receptor signaling 0.002414572 3 NaN SMOC2;SPOCK1
rosiglitazone Antidiabetic No MSN01 Down Osteopontin receptor signaling 0.018877911 14.5 NaN SPP1
rosiglitazone Antidiabetic No MSN02 Down Osteopontin receptor signaling 0.021083275 12.5 NaN SPP1
rosiglitazone Antidiabetic No MSN05 Down Osteopontin receptor signaling 0.016055046 11 NaN SPP1
rosiglitazone Antidiabetic No MSN08 Down Osteopontin receptor signaling 0.019142555 11.5 NaN SPP1
rosiglitazone Antidiabetic No MSN09 Down Osteopontin receptor signaling 0.020377558 14 NaN SPP1
rosiglitazone Antidiabetic No MSN08 Up Platelet-derived growth factor receptor signaling 0.030213822 22 NaN FOSL1;PDGFRB
rosiglitazone Antidiabetic No MSN01 Down Platelet-derived growth factor receptor signaling 0.017439282 12 NaN PDGFRA;TNK2
rosiglitazone Antidiabetic No MSN02 Down Platelet-derived growth factor receptor signaling 0.02147651 15.5 NaN PDGFRA;TNK2
rosiglitazone Antidiabetic No MSN08 Down Platelet-derived growth factor receptor signaling 0.017904373 9 NaN PDGFRA;TNK2
rosiglitazone Antidiabetic No MSN02 Up Potassium transmembrane transport 0.019988845 10 NaN KCNE4;KCNK2;KCNK5
rosiglitazone Antidiabetic No MSN01 Down Prostaglandin PGF2 alpha receptor signaling 0.037401081 20.5 NaN PTGFR
rosiglitazone Antidiabetic No MSN05 Down Prostaglandin PGF2 alpha receptor signaling 0.031853721 16.5 NaN PTGFR
rosiglitazone Antidiabetic No MSN08 Down Prostaglandin PGF2 alpha receptor signaling 0.037920328 17 NaN PTGFR
rosiglitazone Antidiabetic No MSN09 Down Prostaglandin PGF2 alpha receptor signaling 0.040341633 22 NaN PTGFR
rosiglitazone Antidiabetic No MSN09 Down Regulation of coagulation cascade by protein C 0.002414572 3 NaN PROCR;THBD
rosiglitazone Antidiabetic No MSN01 Down Removal of caspase inhibition 0.037401081 20.5 NaN XAF1
rosiglitazone Antidiabetic No MSN05 Down Removal of caspase inhibition 0.031853721 16.5 NaN XAF1
rosiglitazone Antidiabetic No MSN08 Down Removal of caspase inhibition 0.037920328 17 NaN XAF1
rosiglitazone Antidiabetic No MSN09 Down Removal of caspase inhibition 0.040341633 22 NaN XAF1
rosiglitazone Antidiabetic No MSN02 Up Restriction point 0.023521317 12 NaN CCND2;E2F1
rosiglitazone Antidiabetic No MSN01 Up Retinol metabolism 0.043307043 21.5 NaN DHRS3;RLBP1
rosiglitazone Antidiabetic No MSN02 Up Retinol metabolism 0.003441711 4 NaN ALDH1A1;DHRS3;RLBP1
rosiglitazone Antidiabetic No MSN08 Up Retinol metabolism 0.041452288 24 NaN DHRS3;RLBP1
rosiglitazone Antidiabetic No MSN09 Up Retinol metabolism 0.036831666 16 NaN DHRS3;RLBP1
rosiglitazone Antidiabetic No MSN08 Up RIG-I-like receptor signaling 0.003705518 7 NaN DDX58;DHX58
rosiglitazone Antidiabetic No MSN08 Up Roundabout signaling 0.012331868 13 NaN ROBO2;ROBO3
rosiglitazone Antidiabetic No MSN01 Up Serine and glycine metabolism 0.031591061 20 NaN SHMT2;SLC1A5
rosiglitazone Antidiabetic No MSN02 Up Serine and glycine metabolism 0.028290753 15 NaN GLDC;PSAT1
rosiglitazone Antidiabetic No MSN05 Up Serine and glycine metabolism 0.000204921 3 NaN GLDC;PHGDH;SHMT2;SLC1A5
rosiglitazone Antidiabetic No MSN08 Up Serine and glycine metabolism 0.002278637 3 NaN GLDC;PSAT1;SLC1A5
rosiglitazone Antidiabetic No MSN09 Up Serine and glycine metabolism 0.001893039 3 NaN PHGDH;SHMT2;SLC1A5
rosiglitazone Antidiabetic No MSN02 Up Serotonin inactivation 0.048275867 19.5 NaN MAOA
rosiglitazone Antidiabetic No MSN08 Up Serotonin inactivation 0.049996342 28.5 NaN MAOA
rosiglitazone Antidiabetic No MSN09 Down Serotonin inactivation 0.040341633 22 NaN MAOA
rosiglitazone Antidiabetic No MSN08 Up Syndecan ectodomain shedding 0.003705518 7 NaN ADAMTS1;MMP7
rosiglitazone Antidiabetic No MSN01 Down Thrombospondin receptor signaling 0.002075737 3 NaN THBS2;THBS4
rosiglitazone Antidiabetic No MSN02 Down Thrombospondin receptor signaling 0.002582626 3 NaN THBS2;THBS4
rosiglitazone Antidiabetic No MSN05 Down Thrombospondin receptor signaling 0.001505846 2 NaN THBS2;THBS4
rosiglitazone Antidiabetic No MSN08 Down Thrombospondin receptor signaling 0.00213372 2 NaN THBS2;THBS4
rosiglitazone Antidiabetic No MSN09 Down Thrombospondin receptor signaling 0.002414572 3 NaN THBS2;THBS4
rosiglitazone Antidiabetic No MSN09 Up Tight junction organization 0.04605371 20 NaN CRB2;CRB3;MYLK
rosiglitazone Antidiabetic No MSN09 Down Tight junction organization 0.03142457 19 NaN CGNL1;CLDN4;CLDN6
rosiglitazone Antidiabetic No MSN01 Up Tropoelastin synthesis 0.025935074 18 NaN ELN
rosiglitazone Antidiabetic No MSN02 Up Tropoelastin synthesis 0.024435427 13.5 NaN ELN
rosiglitazone Antidiabetic No MSN05 Up Tropoelastin synthesis 0.029375441 18 NaN ELN
rosiglitazone Antidiabetic No MSN08 Up Tropoelastin synthesis 0.025317572 20.5 NaN ELN
rosiglitazone Antidiabetic No MSN09 Down Tropoelastin synthesis 0.020377558 14 NaN ELN
rosiglitazone Antidiabetic No MSN05 Up Urea cycle 0.011933343 13 NaN ARG2;ASS1
rosiglitazone Antidiabetic No MSN01 Down Versican receptor signaling 0.037401081 20.5 NaN VCAN
rosiglitazone Antidiabetic No MSN02 Down Versican receptor signaling 0.041723865 19 NaN VCAN
rosiglitazone Antidiabetic No MSN08 Down Versican receptor signaling 0.037920328 17 NaN VCAN
rosiglitazone Antidiabetic No MSN09 Down Versican receptor signaling 0.040341633 22 NaN VCAN
rosiglitazone Antidiabetic No MSN01 Down Versican synthesis 0.018877911 14.5 NaN VCAN
rosiglitazone Antidiabetic No MSN02 Down Versican synthesis 0.021083275 12.5 NaN VCAN
rosiglitazone Antidiabetic No MSN08 Down Versican synthesis 0.019142555 11.5 NaN VCAN
rosiglitazone Antidiabetic No MSN09 Down Versican synthesis 0.020377558 14 NaN VCAN
rosiglitazone Antidiabetic No MSN05 Down ER unfolded protein response pathway 0.006735652 6.5 NaN DDIT3;PPP1R15A
rosiglitazone Antidiabetic No MSN01 Up Extracellular matrix breakdown and membrane shedding by adamalysins 0.023360518 17 NaN ADAMTS10;ADAMTS2;ADAMTS6
rosiglitazone Antidiabetic No MSN02 Up Extracellular matrix breakdown and membrane shedding by adamalysins 1.17E-06 1 NaN ADAM19;ADAM33;ADAMTS1;ADAMTS12;ADAMTS2;ADAMTS5;ADAMTS9
rosiglitazone Antidiabetic No MSN05 Up Extracellular matrix breakdown and membrane shedding by adamalysins 0.0005693 5 NaN ADAM33;ADAMTS1;ADAMTS14;ADAMTS2;ADAMTS5
rosiglitazone Antidiabetic No MSN08 Up Extracellular matrix breakdown and membrane shedding by adamalysins 2.29E-05 2 NaN ADAM19;ADAM33;ADAMTS1;ADAMTS2;ADAMTS5;ADAMTS9
rosiglitazone Antidiabetic No MSN09 Up Extracellular matrix breakdown and membrane shedding by adamalysins 1.59E-05 1 NaN ADAM19;ADAMTS1;ADAMTS12;ADAMTS2;ADAMTS5;ADAMTS9
rosiglitazone Antidiabetic No MSN08 Down Extracellular matrix breakdown and membrane shedding by adamalysins 0.010408866 7 NaN ADAM12;ADAMTS14;ADAMTS8
rosiglitazone Antidiabetic No MSN01 Down Extracellular matrix breakdown by cathepsins 0.014446446 10.5 NaN CTSF;CTSZ
rosiglitazone Antidiabetic No MSN02 Down Extracellular matrix breakdown by cathepsins 0.017816642 10 NaN CTSF;CTSZ
rosiglitazone Antidiabetic No MSN08 Down Extracellular matrix breakdown by cathepsins 0.014834304 8 NaN CTSB;CTSZ
rosiglitazone Antidiabetic No MSN09 Down Extracellular matrix breakdown by cathepsins 0.016704296 10 NaN CTSF;CTSZ
rosiglitazone Antidiabetic No MSN08 Up Extracellular matrix breakdown by matrix metalloproteases 0.020445489 17.5 NaN MMP1;MMP7
rosiglitazone Antidiabetic No MSN09 Down Extracellular matrix breakdown by matrix metalloproteases 0.013543754 9 NaN MMP14;MMP2
rosiglitazone Antidiabetic No MSN01 Down Extracellular matrix breakdown by serine proteases 0.006997877 7 NaN KLK5;PRSS12
rosiglitazone Antidiabetic No MSN02 Down Extracellular matrix breakdown by serine proteases 0.008668292 6.5 NaN KLK5;PRSS12
rosiglitazone Antidiabetic No MSN08 Down Extracellular matrix breakdown by serine proteases 0.007189535 5 NaN KLK5;PRSS12
rosiglitazone Antidiabetic No MSN09 Down Extracellular matrix breakdown by serine proteases 0.008115724 6 NaN KLK5;PRSS12
rosiglitazone Antidiabetic No MSN05 Down Fatty acid transfer between membranes 0.047400097 21 NaN FABP3
rosiglitazone Antidiabetic No MSN01 Up Fibrillar collagen core structure organization 0.001809764 4.5 NaN COL11A2;COL1A2;COL3A1
rosiglitazone Antidiabetic No MSN02 Up Fibrillar collagen core structure organization 0.00152477 2.5 NaN COL11A2;COL1A2;COL3A1
rosiglitazone Antidiabetic No MSN05 Up Fibrillar collagen core structure organization 0.002585183 7 NaN COL11A2;COL1A2;COL5A1
rosiglitazone Antidiabetic No MSN08 Up Fibrillar collagen core structure organization 0.025134697 19 NaN COL1A2;COL3A1
rosiglitazone Antidiabetic No MSN09 Up Fibrillar collagen core structure organization 0.001401225 2 NaN COL11A2;COL1A2;COL2A1
rosiglitazone Antidiabetic No MSN01 Down Fibrillar collagen core structure organization 0.014446446 10.5 NaN COL11A1;COL1A1
rosiglitazone Antidiabetic No MSN02 Down Fibrillar collagen core structure organization 0.000995243 2 NaN COL1A1;COL2A1;COL5A2
rosiglitazone Antidiabetic No MSN08 Down Fibrillar collagen core structure organization 0.000751664 1 NaN COL11A1;COL2A1;COL5A2
rosiglitazone Antidiabetic No MSN02 Up Fibulin receptor signaling 0.048275867 19.5 NaN FBLN1
rosiglitazone Antidiabetic No MSN08 Up Fibulin receptor signaling 0.049996342 28.5 NaN FBLN1
rosiglitazone Antidiabetic No MSN09 Up Fibulin receptor signaling 0.046898366 21.5 NaN FBLN1
rosiglitazone Antidiabetic No MSN09 Down Filopodium organization 0.000104201 1 NaN DAAM2;FMNL2;GAP43;RHOU;TNK2
rosiglitazone Antidiabetic No MSN01 Down GABA metabolism 0.005061213 4.5 NaN ABAT;SLC6A1
rosiglitazone Antidiabetic No MSN05 Down GABA metabolism 0.003685571 3 NaN ABAT;SLC6A1
rosiglitazone Antidiabetic No MSN08 Down GABA metabolism 0.005200747 3.5 NaN ABAT;SLC6A1
rosiglitazone Antidiabetic No MSN01 Up Gap junction organization 0.049677703 23.5 NaN GJA5;GJA8
rosiglitazone Antidiabetic No MSN02 Up Gap junction organization 0.044617901 16.5 NaN GJA5;GJA8
rosiglitazone Antidiabetic No MSN08 Up Gap junction organization 0.047569054 26 NaN GJA1;GJA8
rosiglitazone Antidiabetic No MSN09 Up Gap junction organization 0.042309999 18.5 NaN GJA5;GJA8
rosiglitazone Antidiabetic No MSN01 Up Glutamate and glutamine metabolism 0.043307043 21.5 NaN SLC1A5;SLC7A5
rosiglitazone Antidiabetic No MSN08 Up Glutamate and glutamine metabolism 0.041452288 24 NaN SLC1A5;SLC7A5
rosiglitazone Antidiabetic No MSN09 Up Glutamate and glutamine metabolism 0.036831666 16 NaN SLC1A3;SLC1A5
rosiglitazone Antidiabetic No MSN09 Up Glutamate-mediated control of postsynaptic potential 0.025388614 14 NaN GRID2;GRIN2D;GRIN3A
rosiglitazone Antidiabetic No MSN02 Up Glycolysis and Gluconeogenesis 0.01780527 9 NaN ENO1;HK2;LDHA
rosiglitazone Antidiabetic No MSN08 Up Glycolysis and Gluconeogenesis 0.00243598 4 NaN ENO1;HK2;LDHA;PCK2
rosiglitazone Antidiabetic No MSN08 Up Granulocyte macrophage colony-stimulating factor receptor signaling 0.049996342 28.5 NaN JAK2
rosiglitazone Antidiabetic No MSN01 Up Granulocyte-colony stimulating factor receptor signaling 0.021394782 16 NaN SOCS3;STAT3
rosiglitazone Antidiabetic No MSN08 Up Granulocyte-colony stimulating factor receptor signaling 0.020445489 17.5 NaN SOCS3;STAT3
rosiglitazone Antidiabetic No MSN01 Down Growth differentiation factor receptor signaling 0.009215038 9 NaN GDF2;GDF6
rosiglitazone Antidiabetic No MSN05 Down Growth differentiation factor receptor signaling 0.006735652 6.5 NaN GDF2;GDF6
rosiglitazone Antidiabetic No MSN09 Down Growth differentiation factor receptor signaling 0.010676413 7.5 NaN GDF2;GDF6
rosiglitazone Antidiabetic No MSN02 Up Hepatocyte growth factor receptor signaling 0.048275867 19.5 NaN HGF
rosiglitazone Antidiabetic No MSN05 Down Hepatocyte growth factor receptor signaling 0.031853721 16.5 NaN HGF
rosiglitazone Antidiabetic No MSN09 Down Hepatocyte growth factor receptor signaling 0.040341633 22 NaN HGF
rosiglitazone Antidiabetic No MSN09 Up Hippo signaling 0.022960869 12 NaN AMOTL1;CRB2;CRB3
rosiglitazone Antidiabetic No MSN05 Down Hyaluronan synthesis 0.047400097 21 NaN HAS2
rosiglitazone Antidiabetic No MSN01 Up Inhibin receptor signaling 0.01692739 14 NaN INHBE;TGFBR3
rosiglitazone Antidiabetic No MSN02 Up Inhibin receptor signaling 0.015114208 8 NaN INHBB;INHBE
rosiglitazone Antidiabetic No MSN05 Up Inhibin receptor signaling 0.021425951 16.5 NaN INHBE;TGFBR3
rosiglitazone Antidiabetic No MSN08 Up Inhibin receptor signaling 0.016169721 15.5 NaN INHBB;INHBE
rosiglitazone Antidiabetic No MSN09 Up Inhibin receptor signaling 0.014292788 10 NaN INHBA;TGFBR3
rosiglitazone Antidiabetic No MSN05 Down Inhibition of amyloid aggregation, amyloid degradation and uptake 0.000760969 1 NaN MME;PLAT
rosiglitazone Antidiabetic No MSN05 Down Inhibition of apoptosis 0.015221369 8 NaN BIRC3;XAF1
rosiglitazone Antidiabetic No MSN09 Down Inhibition of apoptosis 0.023853258 17 NaN BIRC3;XAF1
rosiglitazone Antidiabetic No MSN05 Down Inhibition of matrix metalloproteinase and adamalysin activity 0.047400097 21 NaN TIMP1
rosiglitazone Antidiabetic No MSN05 Down Insulin receptor signaling 0.023465436 14 NaN IRS2;PIK3CD
rosiglitazone Antidiabetic No MSN01 Up Interferon alpha receptor signaling 0.01692739 14 NaN IRF9;STAT1
rosiglitazone Antidiabetic No MSN08 Up Interferon alpha receptor signaling 0.016169721 15.5 NaN IRF9;STAT1
rosiglitazone Antidiabetic No MSN01 Up JAK-STAT signaling pathway 0.000361252 2 NaN SOCS2;SOCS3;STAT1;STAT3
rosiglitazone Antidiabetic No MSN02 Up JAK-STAT signaling pathway 0.044617901 16.5 NaN SOCS2;STAT3
rosiglitazone Antidiabetic No MSN08 Up JAK-STAT signaling pathway 1.67E-05 1 NaN SOCS2;SOCS3;STAT1;STAT3;STAT4
rosiglitazone Antidiabetic No MSN01 Up Leptin receptor signaling 0.003885554 6 NaN SOCS3;STAT3
rosiglitazone Antidiabetic No MSN08 Up Leptin receptor signaling 0.003705518 7 NaN SOCS3;STAT3
rosiglitazone Antidiabetic No MSN05 Up Lipogenesis 0.000860401 6 NaN ACLY;FASN
rosiglitazone Antidiabetic No MSN05 Down Lysine metabolism 0.047400097 21 NaN LOX
rosiglitazone Antidiabetic No MSN05 Up Macrophage migration inhibitory factor signaling 0.008112355 9.5 NaN ACKR3;JUND
rosiglitazone Antidiabetic No MSN05 Down Methionine cycle 0.031853721 16.5 NaN BHMT
rosiglitazone Antidiabetic No MSN08 Down Methionine cycle 0.037920328 17 NaN BHMT
rosiglitazone Antidiabetic No MSN01 Down Microfibril scaffold organization 0.037401081 20.5 NaN FBN1
rosiglitazone Antidiabetic No MSN02 Down Microfibril scaffold organization 0.041723865 19 NaN FBN1
rosiglitazone Antidiabetic No MSN08 Down Microfibril scaffold organization 0.037920328 17 NaN FBN1
rosiglitazone Antidiabetic No MSN01 Up Mitotic chromosome condensation 0.012914996 11.5 NaN INCENP;NCAPG2
rosiglitazone Antidiabetic No MSN09 Down WNT-Beta-catenin signaling pathway 0.041284933 25 NaN AMER1;DKK2;PAX6;SFRP2
rituximab Monoclonal antibody No MSN08 Down WNT-Beta-catenin signaling pathway 0.034993337 10 NaN DKK2;FZD7;SFRP2;WNT9A
rituximab Monoclonal antibody No MSN09 Down Z-disc organization 0.049854732 14 NaN CSRP3;TCAP
rituximab Monoclonal antibody No MSN08 Down Natriuretic peptide receptor signaling 0.005294767 1 NaN NPPA;NPPB
rituximab Monoclonal antibody No MSN06 Up Non-vesicular phospholipid transport 0.011123733 9.5 NaN PITPNM1;PLTP
rituximab Monoclonal antibody No MSN06 Up Osteonectin receptor signaling 0.003333624 5 NaN SPARC;SPOCK1
rituximab Monoclonal antibody No MSN08 Up Osteonectin receptor signaling 0.003480103 7.5 NaN SMOC2;SPOCK1
rituximab Monoclonal antibody No MSN05 Up Osteopontin receptor signaling 0.019936486 8.5 NaN SPP1
rituximab Monoclonal antibody No MSN08 Up Perlecan synthesis 0.024523641 15 NaN HSPG2
rituximab Monoclonal antibody No MSN09 Up Perlecan synthesis 0.022141849 12 NaN HSPG2
rituximab Monoclonal antibody No MSN06 Up Platelet-derived growth factor receptor signaling 0.027349088 17 NaN PDGFRB;TNK2
rituximab Monoclonal antibody No MSN08 Up Platelet-derived growth factor receptor signaling 0.028480684 17 NaN FOSL1;TNK2
rituximab Monoclonal antibody No MSN09 Up Platelet-derived growth factor receptor signaling 0.023542064 14 NaN FOSL1;TNK2
rituximab Monoclonal antibody No MSN06 Down Platelet-derived growth factor receptor signaling 0.020972888 11 NaN PDGFD;PDGFRA
rituximab Monoclonal antibody No MSN05 Down Potassium transmembrane transport 0.018868897 8 NaN ATP1A2;ATP1A3;KCNQ1
rituximab Monoclonal antibody No MSN08 Up Progesterone receptor signaling 0.024523641 15 NaN PGR
rituximab Monoclonal antibody No MSN05 Down Progesterone receptor signaling 0.02390614 11 NaN PGR
rituximab Monoclonal antibody No MSN05 Down Prostaglandin E2 receptor signaling 0.00801527 6.5 NaN PTGER3;RAPGEF4
rituximab Monoclonal antibody No MSN06 Down Prostaglandin E2 receptor signaling 0.006125965 5.5 NaN PTGER3;RAPGEF4
rituximab Monoclonal antibody No MSN05 Up Prostaglandin PGF2 alpha receptor signaling 0.039477231 15.5 NaN PTGFR
rituximab Monoclonal antibody No MSN05 Up Protein polyubiquitination 0.039518883 17 NaN ISG15;UCHL1
rituximab Monoclonal antibody No MSN05 Down Removal of caspase inhibition 0.047242835 15.5 NaN XAF1
rituximab Monoclonal antibody No MSN06 Down Removal of caspase inhibition 0.041205645 14.5 NaN XAF1
rituximab Monoclonal antibody No MSN08 Down Removal of caspase inhibition 0.038266416 11.5 NaN XAF1
rituximab Monoclonal antibody No MSN09 Down Removal of caspase inhibition 0.044830247 12 NaN XAF1
rituximab Monoclonal antibody No MSN05 Up Retinol metabolism 0.026709042 11.5 NaN ALDH1A2;STRA6
rituximab Monoclonal antibody No MSN06 Up Retinol metabolism 0.03758663 18 NaN ALDH1A3;STRA6
rituximab Monoclonal antibody No MSN08 Up Retinol metabolism 0.003476939 6 NaN ALDH1A2;RLBP1;STRA6
rituximab Monoclonal antibody No MSN09 Up Selectin-mediated Leukocyte rolling 0.006906563 5 NaN SELPLG;VCAM1
rituximab Monoclonal antibody No MSN06 Up Semaphorin signaling 0.008536055 8 NaN CRMP1;PLXNA2;PLXNA4;PLXND1
rituximab Monoclonal antibody No MSN08 Up Semaphorin signaling 0.049939927 22 NaN CRMP1;PLXNA4;PLXND1
rituximab Monoclonal antibody No MSN09 Up Semaphorin signaling 0.038761798 16.5 NaN CRMP1;PLXNA4;PLXND1
rituximab Monoclonal antibody No MSN06 Down Serine and glycine metabolism 0.001299007 2 NaN PHGDH;SHMT2;SLC1A4
rituximab Monoclonal antibody No MSN09 Down Serine and glycine metabolism 0.001660577 2 NaN PHGDH;SHMT2;SLC1A4
rituximab Monoclonal antibody No MSN06 Down Serotonin inactivation 0.041205645 14.5 NaN MAOA
rituximab Monoclonal antibody No MSN08 Up Sulfonation 0.005706386 9 NaN SULT1A1;SULT1E1
rituximab Monoclonal antibody No MSN05 Down Thrombospondin receptor signaling 0.003309507 4 NaN THBS2;THBS4
rituximab Monoclonal antibody No MSN09 Down Thrombospondin receptor signaling 0.002980769 3 NaN THBS2;THBS4
rituximab Monoclonal antibody No MSN05 Up Tight junction organization 0.029717612 13 NaN CGN;CLDN1;CLDN6
rituximab Monoclonal antibody No MSN06 Up Tight junction organization 0.047331485 21 NaN CGN;CLDN6;CRB2
rituximab Monoclonal antibody No MSN08 Up Tight junction organization 0.009201964 10 NaN CLDN11;CLDN19;CLDN6;CRB2
rituximab Monoclonal antibody No MSN09 Up Tight junction organization 0.038761798 16.5 NaN CLDN19;CLDN6;CRB2
rituximab Monoclonal antibody No MSN05 Up Tropoelastin synthesis 0.019936486 8.5 NaN ELN
rituximab Monoclonal antibody No MSN06 Up Tropoelastin synthesis 0.023994354 16 NaN ELN
rituximab Monoclonal antibody No MSN08 Up Tropoelastin synthesis 0.024523641 15 NaN ELN
rituximab Monoclonal antibody No MSN09 Up Tropoelastin synthesis 0.022141849 12 NaN ELN
rituximab Monoclonal antibody No MSN06 Down Vasoactive intestinal peptide receptor signaling 0.041205645 14.5 NaN VIPR2
rituximab Monoclonal antibody No MSN05 Up Versican receptor signaling 0.039477231 15.5 NaN VCAN
rituximab Monoclonal antibody No MSN05 Up Versican synthesis 0.019936486 8.5 NaN VCAN
rituximab Monoclonal antibody No MSN05 Up Actin filament bundling and crosslinking 0.014497956 5 NaN FSCN2;TAGLN;USH1C
rituximab Monoclonal antibody No MSN08 Down Adenylyl cyclase signaling pathway 0.046398674 13 NaN ADCY1;RAPGEF4
rituximab Monoclonal antibody No MSN09 Down Adrenergic receptor signaling 0.020377978 7 NaN ADCY2;RAPGEF4;RGS4
rituximab Monoclonal antibody No MSN05 Down Aggrecan synthesis 0.02390614 11 NaN ACAN
rituximab Monoclonal antibody No MSN06 Down Aggrecan synthesis 0.020818631 8.5 NaN ACAN
rituximab Monoclonal antibody No MSN08 Down Aggrecan synthesis 0.019318984 6.5 NaN ACAN
rituximab Monoclonal antibody No MSN09 Down Aggrecan synthesis 0.022671136 8.5 NaN ACAN
rituximab Monoclonal antibody No MSN05 Down Albumin mediated blood protein transport 0.02390614 11 NaN ALB
rituximab Monoclonal antibody No MSN06 Down Albumin mediated blood protein transport 0.020818631 8.5 NaN ALB
rituximab Monoclonal antibody No MSN08 Down Albumin mediated blood protein transport 0.019318984 6.5 NaN ALB
rituximab Monoclonal antibody No MSN08 Down Androgen synthesis 0.012230733 3 NaN AKR1C3;HSD17B2
rituximab Monoclonal antibody No MSN06 Up Antigen presentation via MHC class I molecules 0.022731834 14 NaN HLA-B;HLA-C
rituximab Monoclonal antibody No MSN08 Up Antigen presentation via MHC class I molecules 0.023680597 12.5 NaN HLA-B;HLA-C
rituximab Monoclonal antibody No MSN09 Up Antigen presentation via MHC class I molecules 0.019543779 9 NaN HLA-B;HLA-C
rituximab Monoclonal antibody No MSN05 Down Axonal intermediate filament dynamics 0.000440408 3 NaN NEFH;NEFL;NES
rituximab Monoclonal antibody No MSN08 Up Basement membrane assembly and organization 0.001540682 5 NaN COL4A4;COL8A2;HSPG2
rituximab Monoclonal antibody No MSN09 Up Basement membrane assembly and organization 0.019543779 9 NaN COL4A4;HSPG2
rituximab Monoclonal antibody No MSN05 Up Biglycan synthesis 0.019936486 8.5 NaN BGN
rituximab Monoclonal antibody No MSN09 Up Biglycan synthesis 0.022141849 12 NaN BGN
rituximab Monoclonal antibody No MSN09 Down Calcitonin receptor signaling 0.044830247 12 NaN RAMP1
rituximab Monoclonal antibody No MSN05 Up Cardiomyocyte repolarization during action potential and hyperpolarization 0.030757337 14 NaN KCNIP2;KCNJ2
rituximab Monoclonal antibody No MSN06 Up Cardiomyocyte repolarization during action potential and hyperpolarization 0.043169865 19.5 NaN KCNIP2;KCNJ2
rituximab Monoclonal antibody No MSN08 Up Cardiomyocyte repolarization during action potential and hyperpolarization 0.044909729 19.5 NaN KCNIP2;KCNJ2
rituximab Monoclonal antibody No MSN09 Down Cardiomyocyte repolarization during action potential and hyperpolarization 0.038938896 10 NaN KCNA1;KCNQ1
rituximab Monoclonal antibody No MSN06 Up Carnitine shuttle 0.011123733 9.5 NaN CPT1A;CPT1B
rituximab Monoclonal antibody No MSN05 Down CCN intercellular signaling protein family receptor signaling 0.00542891 5 NaN NOV;WISP1
rituximab Monoclonal antibody No MSN06 Down CCN intercellular signaling protein family receptor signaling 0.004140681 4 NaN NOV;WISP1
rituximab Monoclonal antibody No MSN09 Down CCN intercellular signaling protein family receptor signaling 0.004893708 4 NaN NOV;WISP1
rituximab Monoclonal antibody No MSN06 Down Cellular cholesterol uptake and efflux 0.002183285 3 NaN ABCA1;ABCG1;MYLIP
rituximab Monoclonal antibody No MSN08 Down Cellular cholesterol uptake and efflux 0.025189984 9 NaN ABCA1;ABCG1
rituximab Monoclonal antibody No MSN08 Down Centrosome duplication 0.011956352 2 NaN CDKN1A;GADD45A;PLK2
rituximab Monoclonal antibody No MSN06 Up Centrosome separation 0.022731834 14 NaN CCNB1;NEK6
rituximab Monoclonal antibody No MSN06 Up Cholesterol synthesis 8.84E-05 2 NaN DHCR24;DHCR7;HMGCR;MSMO1;MVD
rituximab Monoclonal antibody No MSN08 Up Cholesterol synthesis 5.98E-06 2 NaN DHCR24;DHCR7;HMGCR;HMGCS1;MSMO1;MVD
rituximab Monoclonal antibody No MSN05 Down Cholesterol-sensitive control of SREBP activation 0.00801527 6.5 NaN INSIG1;SREBF1
rituximab Monoclonal antibody No MSN05 Up Collagen fibril organization by fibril-associated bridges 0.0056301 3 NaN COL9A1;COL9A3
rituximab Monoclonal antibody No MSN06 Up Collagen fibril organization by fibril-associated bridges 0.008072724 7 NaN COL9A2;COL9A3
rituximab Monoclonal antibody No MSN08 Up Collagen fibril organization by fibril-associated bridges 0.000276247 4 NaN COL9A1;COL9A2;COL9A3
rituximab Monoclonal antibody No MSN09 Up Collagen fibril organization by fibril-associated bridges 0.000204193 4 NaN COL9A1;COL9A2;COL9A3
rituximab Monoclonal antibody No MSN06 Up Contractile ring constriction 0.005468147 6 NaN ANLN;MYH14
rituximab Monoclonal antibody No MSN05 Down Decorin synthesis 0.02390614 11 NaN DCN
rituximab Monoclonal antibody No MSN06 Down Decorin synthesis 0.020818631 8.5 NaN DCN
rituximab Monoclonal antibody No MSN08 Down Decorin synthesis 0.019318984 6.5 NaN DCN
rituximab Monoclonal antibody No MSN09 Down Decorin synthesis 0.022671136 8.5 NaN DCN
rituximab Monoclonal antibody No MSN09 Down Electron transport chain 0.000110683 1 NaN COX7A1;NDUFA4;NDUFS4;NDUFV2
rituximab Monoclonal antibody No MSN05 Up Epithelial intermediate filament dynamics 0.010236386 4 NaN KRT19;KRT4
rituximab Monoclonal antibody No MSN09 Up Epithelial intermediate filament dynamics 0.012520391 7 NaN KRT19;KRT4
rituximab Monoclonal antibody No MSN05 Up Extracellular matrix breakdown and membrane shedding by adamalysins 0.001194517 2 NaN ADAMTS1;ADAMTS12;ADAMTS14;ADAMTS8
rituximab Monoclonal antibody No MSN06 Up Extracellular matrix breakdown and membrane shedding by adamalysins 0.019053024 12 NaN ADAMTS1;ADAMTS12;ADAMTS9
rituximab Monoclonal antibody No MSN09 Up Extracellular matrix breakdown and membrane shedding by adamalysins 1.07E-05 1 NaN ADAM15;ADAMTS1;ADAMTS12;ADAMTS14;ADAMTS17;ADAMTS9
rituximab Monoclonal antibody No MSN05 Up Extracellular matrix breakdown by cathepsins 0.016025171 6 NaN CTSD;CTSV
rituximab Monoclonal antibody No MSN06 Up Extracellular matrix breakdown by cathepsins 0.022731834 14 NaN CTSD;CTSV
rituximab Monoclonal antibody No MSN08 Up Extracellular matrix breakdown by cathepsins 0.023680597 12.5 NaN CTSD;CTSV
rituximab Monoclonal antibody No MSN09 Up Extracellular matrix breakdown by cathepsins 0.019543779 9 NaN CTSD;CTSV
rituximab Monoclonal antibody No MSN05 Up Extracellular matrix breakdown by matrix metalloproteases 1.79E-05 1 NaN MMP12;MMP14;MMP2;MMP3
rituximab Monoclonal antibody No MSN06 Up Extracellular matrix breakdown by matrix metalloproteases 0.00103097 4 NaN MMP12;MMP14;MMP3
rituximab Monoclonal antibody No MSN08 Up Extracellular matrix breakdown by matrix metalloproteases 9.95E-07 1 NaN MMP1;MMP12;MMP14;MMP2;MMP3
rituximab Monoclonal antibody No MSN09 Up Extracellular matrix breakdown by matrix metalloproteases 2.71E-05 2 NaN MMP12;MMP14;MMP2;MMP3
rituximab Monoclonal antibody No MSN06 Up Fibrillar collagen core structure organization 3.50E-08 1 NaN COL11A2;COL1A1;COL1A2;COL2A1;COL3A1;COL5A2
rituximab Monoclonal antibody No MSN08 Up Fibrillar collagen core structure organization 6.62E-05 3 NaN COL11A2;COL1A1;COL2A1;COL5A1
rituximab Monoclonal antibody No MSN09 Up Fibrillar collagen core structure organization 4.44E-05 3 NaN COL11A2;COL2A1;COL3A1;COL5A2
rituximab Monoclonal antibody No MSN05 Down Fibrillar collagen core structure organization 1.72E-06 1 NaN COL11A1;COL1A1;COL1A2;COL5A1;COL5A3
rituximab Monoclonal antibody No MSN08 Down Fibrillar collagen core structure organization 0.015095412 4 NaN COL11A1;COL1A2
rituximab Monoclonal antibody No MSN06 Up Gap junction organization 0.043169865 19.5 NaN GJA1;GJA5
rituximab Monoclonal antibody No MSN05 Down Glucuronidation 0.02390614 11 NaN UGT2B4
rituximab Monoclonal antibody No MSN06 Down Glucuronidation 0.020818631 8.5 NaN UGT2B4
rituximab Monoclonal antibody No MSN08 Down Glucuronidation 0.019318984 6.5 NaN UGT2B4
rituximab Monoclonal antibody No MSN05 Up Glutamate and glutamine metabolism 0.026709042 11.5 NaN SLC1A5;SLC7A5
rituximab Monoclonal antibody No MSN06 Up Glutamate and glutamine metabolism 0.000195395 3 NaN FOLH1;SLC1A3;SLC1A5;SLC7A5
rituximab Monoclonal antibody No MSN08 Up Glutamate and glutamine metabolism 0.039114857 18 NaN SLC1A5;SLC7A5
rituximab Monoclonal antibody No MSN09 Up Glutamate and glutamine metabolism 0.032432748 15 NaN SLC1A3;SLC1A5
rituximab Monoclonal antibody No MSN05 Down Glycolysis and Gluconeogenesis 0.000177835 2 NaN ALDOA;LDHA;PCK2;PGK1;TPI1
rituximab Monoclonal antibody No MSN06 Down Glycolysis and Gluconeogenesis 0.001187546 1 NaN HK2;LDHA;PGK1;TPI1
rituximab Monoclonal antibody No MSN09 Down Glycolysis and Gluconeogenesis 0.014587162 6 NaN LDHA;PGK1;TPI1
rituximab Monoclonal antibody No MSN06 Up Granulocyte-colony stimulating factor receptor signaling 0.018474823 11 NaN INPP5D;STAT3
rituximab Monoclonal antibody No MSN08 Up Granulocyte-colony stimulating factor receptor signaling 0.019252614 11 NaN SOCS3;STAT3
rituximab Monoclonal antibody No MSN05 Down Hepatocyte growth factor receptor signaling 0.047242835 15.5 NaN MET
rituximab Monoclonal antibody No MSN09 Down Hepatocyte growth factor receptor signaling 0.044830247 12 NaN MET
rituximab Monoclonal antibody No MSN06 Down Inhibition of apoptosis 0.024826363 12 NaN IFI6;XAF1
rituximab Monoclonal antibody No MSN06 Up Inositol metabolism and transport 0.047415046 22.5 NaN INPP5D
rituximab Monoclonal antibody No MSN09 Up Integrin-mediated leukocyte rolling 0.009528592 6 NaN SELPLG;VCAM1
rituximab Monoclonal antibody No MSN08 Up JAK-STAT signaling pathway 0.044909729 19.5 NaN SOCS3;STAT3
rituximab Monoclonal antibody No MSN08 Up Leptin receptor signaling 0.003480103 7.5 NaN SOCS3;STAT3
rituximab Monoclonal antibody No MSN06 Up Lipogenesis 0.047415046 22.5 NaN FASN
rituximab Monoclonal antibody No MSN08 Up Lipogenesis 0.048447984 21 NaN FASN
rituximab Monoclonal antibody No MSN09 Up Lipogenesis 0.043795347 18 NaN FASN
rituximab Monoclonal antibody No MSN05 Down Methionine cycle 0.047242835 15.5 NaN BHMT
rituximab Monoclonal antibody No MSN06 Down Methionine cycle 0.041205645 14.5 NaN BHMT
rituximab Monoclonal antibody No MSN05 Down Microfibril scaffold organization 0.047242835 15.5 NaN FBN1
rituximab Monoclonal antibody No MSN08 Down Microfibril scaffold organization 0.038266416 11.5 NaN FBN1
rituximab Monoclonal antibody No MSN06 Down Microtubule polymerization 0.006125965 5.5 NaN DCLK1;TUBA1A
rituximab Monoclonal antibody No MSN09 Down Microtubule polymerization 0.00723107 5 NaN DCLK1;TUBA1A
regorafenib Kinase inhibitor No MSN01 Down ER unfolded protein response pathway 0.010676413 5.5 NaN ATF4;HERPUD1
regorafenib Kinase inhibitor No MSN08 Down ER unfolded protein response pathway 0.011766804 7.5 NaN ATF4;HERPUD1
regorafenib Kinase inhibitor No MSN01 Up Eukaryotic kinetochore dynamics 1.66E-09 2 NaN BUB1;CENPE;CENPF;KIF15;KNSTRN;MTUS2;NDC80;NUF2;SPC24;TTK;ZWINT
regorafenib Kinase inhibitor No MSN05 Up Eukaryotic kinetochore dynamics 3.18E-05 4 NaN BUB1;CENPE;CENPF;MTUS2;NDC80;NUF2;TTK
regorafenib Kinase inhibitor No MSN06 Up Eukaryotic kinetochore dynamics 0.015101604 15 NaN BUB1;CENPE;CENPF;MTUS2
regorafenib Kinase inhibitor No MSN08 Up Eukaryotic kinetochore dynamics 2.70E-07 3 NaN BUB1;CENPE;CENPF;MTUS2;NDC80;NUF2;SPC24;TTK;ZWINT
regorafenib Kinase inhibitor No MSN01 Up Extracellular matrix breakdown and membrane shedding by adamalysins 0.022540734 23 NaN ADAM33;ADAMTS15;ADAMTS2
regorafenib Kinase inhibitor No MSN06 Up Extracellular matrix breakdown and membrane shedding by adamalysins 0.021936586 16 NaN ADAMTS12;ADAMTS15;ADAMTS2
regorafenib Kinase inhibitor No MSN08 Up Extracellular matrix breakdown and membrane shedding by adamalysins 0.020755752 22 NaN ADAM33;ADAMTS15;ADAMTS2
regorafenib Kinase inhibitor No MSN05 Down Extracellular matrix breakdown by matrix metalloproteases 0.014567791 8 NaN MMP1;MMP14
regorafenib Kinase inhibitor No MSN06 Up Extracellular matrix breakdown by serine proteases 0.012331868 13 NaN PRSS12;ST14
regorafenib Kinase inhibitor No MSN01 Up Fanconi anemia interstrand cross-link repair pathway 0.02789576 30 NaN BRIP1;FANCI;UBE2T
regorafenib Kinase inhibitor No MSN01 Up Fibrillar collagen core structure organization 0.001739908 12 NaN COL11A1;COL2A1;COL5A1
regorafenib Kinase inhibitor No MSN05 Up Fibrillar collagen core structure organization 6.52E-05 5 NaN COL11A1;COL2A1;COL5A1;COL5A2
regorafenib Kinase inhibitor No MSN06 Up Fibrillar collagen core structure organization 7.49E-05 3 NaN COL11A1;COL2A1;COL5A1;COL5A2
regorafenib Kinase inhibitor No MSN08 Up Fibrillar collagen core structure organization 6.90E-05 6 NaN COL11A1;COL2A1;COL5A1;COL5A2
regorafenib Kinase inhibitor No MSN01 Down Fibrillar collagen core structure organization 0.000901583 3 NaN COL1A1;COL1A2;COL3A1
regorafenib Kinase inhibitor No MSN05 Down Fibrillar collagen core structure organization 3.72E-05 1 NaN COL11A2;COL1A1;COL1A2;COL3A1
regorafenib Kinase inhibitor No MSN06 Down Fibrillar collagen core structure organization 2.89E-05 1 NaN COL11A2;COL1A1;COL1A2;COL3A1
regorafenib Kinase inhibitor No MSN08 Down Fibrillar collagen core structure organization 0.001044316 2 NaN COL1A1;COL1A2;COL3A1
regorafenib Kinase inhibitor No MSN05 Down Fibroblast growth factor receptor signaling 0.025616672 13 NaN FGF10;FGF18
regorafenib Kinase inhibitor No MSN01 Up G2 M transition checkpoint 0.003070918 14 NaN CCNB1;CDC25B;CDK1
regorafenib Kinase inhibitor No MSN05 Up G2 M transition checkpoint 0.033409737 22 NaN CCNB1;CDK1
regorafenib Kinase inhibitor No MSN08 Up G2 M transition checkpoint 0.03430279 28 NaN CCNB1;CDK1
regorafenib Kinase inhibitor No MSN05 Down Gap junction organization 0.034355742 15.5 NaN GJA3;GJA5
regorafenib Kinase inhibitor No MSN06 Down Gap junction organization 0.002388906 6 NaN GJA3;GJA5;GJA8
regorafenib Kinase inhibitor No MSN01 Down Glutamate and glutamine metabolism 0.027816815 11 NaN SLC1A5;SLC7A5
regorafenib Kinase inhibitor No MSN05 Down Glutamate and glutamine metabolism 0.029857781 14 NaN SLC38A2;SLC7A5
regorafenib Kinase inhibitor No MSN06 Down Glutamate and glutamine metabolism 0.02648975 14 NaN SLC38A2;SLC7A5
regorafenib Kinase inhibitor No MSN06 Down Granulocyte macrophage colony-stimulating factor receptor signaling 0.039304304 17 NaN JUND
regorafenib Kinase inhibitor No MSN08 Down Granulocyte macrophage colony-stimulating factor receptor signaling 0.042414608 15 NaN JUND
regorafenib Kinase inhibitor No MSN01 Up Hyaluronan-mediated motility receptor signaling 0.025582216 26.5 NaN HMMR
regorafenib Kinase inhibitor No MSN08 Up Hyaluronan-mediated motility receptor signaling 0.024788285 25 NaN HMMR
regorafenib Kinase inhibitor No MSN01 Down Inhibin receptor signaling 0.010676413 5.5 NaN INHBE;TGFBR3
regorafenib Kinase inhibitor No MSN06 Down Inhibin receptor signaling 0.010149397 10 NaN INHBB;TGFBR3
regorafenib Kinase inhibitor No MSN08 Down Inhibin receptor signaling 0.011766804 7.5 NaN INHBB;TGFBR3
regorafenib Kinase inhibitor No MSN01 Down JAK-STAT signaling pathway 0.032023829 12 NaN SOCS2;STAT1
regorafenib Kinase inhibitor No MSN05 Down JAK-STAT signaling pathway 0.034355742 15.5 NaN SOCS2;SOCS3
regorafenib Kinase inhibitor No MSN05 Up Lipogenesis 0.048275867 24 NaN FASN
regorafenib Kinase inhibitor No MSN06 Up Lipogenesis 0.049996342 22.5 NaN FASN
regorafenib Kinase inhibitor No MSN06 Down Macrophage migration inhibitory factor signaling 0.003770283 7.5 NaN CXCR4;JUND
regorafenib Kinase inhibitor No MSN08 Down Macrophage migration inhibitory factor signaling 0.004385018 5 NaN CXCR4;JUND
regorafenib Kinase inhibitor No MSN01 Up MAPK signaling pathway 0.006805386 19 NaN FOXM1;MAP2K3;MAP2K6;PEBP1
regorafenib Kinase inhibitor No MSN08 Up MAPK signaling pathway 0.037367454 29 NaN FOXM1;MAP2K3;MAP2K6
regorafenib Kinase inhibitor No MSN01 Up Metaphase to anaphase checkpoint 1.98E-05 5 NaN BUB1;BUB1B;CCNB2;CDC20;CENPE;PTTG1;TTK
regorafenib Kinase inhibitor No MSN05 Up Metaphase to anaphase checkpoint 1.47E-05 3 NaN BUB1;BUB1B;CCNB2;CDC20;CENPE;PTTG1;TTK
regorafenib Kinase inhibitor No MSN06 Up Metaphase to anaphase checkpoint 0.000184953 4 NaN BUB1;BUB1B;CCNB2;CDC20;CENPE;PTTG1
regorafenib Kinase inhibitor No MSN08 Up Metaphase to anaphase checkpoint 1.62E-05 5 NaN BUB1;BUB1B;CCNB2;CDC20;CENPE;PTTG1;TTK
regorafenib Kinase inhibitor No MSN01 Down Methionine cycle 0.040341633 14 NaN BHMT
regorafenib Kinase inhibitor No MSN05 Down Methionine cycle 0.041896574 19 NaN BHMT
regorafenib Kinase inhibitor No MSN06 Down Methionine cycle 0.039304304 17 NaN BHMT
regorafenib Kinase inhibitor No MSN08 Down Methionine cycle 0.042414608 15 NaN BHMT
regorafenib Kinase inhibitor No MSN06 Down Microfibril scaffold organization 0.039304304 17 NaN FBN1
regorafenib Kinase inhibitor No MSN01 Up Microtubule destabilization 0.009139439 20 NaN KIF2C;STMN1
regorafenib Kinase inhibitor No MSN08 Up Microtubule destabilization 0.008598393 18 NaN KIF2C;STMN1
regorafenib Kinase inhibitor No MSN01 Up Mitotic H3 phosphorylation and dephosphorylation 0.006197282 17 NaN AURKB;CCNA2
regorafenib Kinase inhibitor No MSN08 Up Mitotic H3 phosphorylation and dephosphorylation 0.005827311 15.5 NaN AURKB;CCNA2
regorafenib Kinase inhibitor No MSN01 Up Mitotic spindle assembly 1.15E-05 4 NaN DLGAP5;NUSAP1;TACC3;TPX2;TTK
regorafenib Kinase inhibitor No MSN05 Up Mitotic spindle assembly 0.000209572 6 NaN DLGAP5;NUSAP1;TPX2;TTK
regorafenib Kinase inhibitor No MSN06 Up Mitotic spindle assembly 0.00380409 8 NaN DLGAP5;NUSAP1;TPX2
regorafenib Kinase inhibitor No MSN08 Up Mitotic spindle assembly 9.88E-06 4 NaN DLGAP5;NUSAP1;TACC3;TPX2;TTK
regorafenib Kinase inhibitor No MSN01 Up Mitotic spindle disassembly 0.025582216 26.5 NaN CDK1
regorafenib Kinase inhibitor No MSN05 Up Mitotic spindle disassembly 0.024435427 19 NaN CDK1
regorafenib Kinase inhibitor No MSN08 Up Mitotic spindle disassembly 0.024788285 25 NaN CDK1
regorafenib Kinase inhibitor No MSN06 Up Muscarinic receptor signaling 0.008957388 10.5 NaN CHRM4;RGS5
regorafenib Kinase inhibitor No MSN08 Up Muscarinic receptor signaling 0.008598393 18 NaN CHRM4;RGS5
regorafenib Kinase inhibitor No MSN01 Down Myofibril formation 0.016704296 8 NaN DES;MYOZ1
regorafenib Kinase inhibitor No MSN05 Down Myofibril formation 0.017957896 9.5 NaN DES;MYOZ1
regorafenib Kinase inhibitor No MSN08 Down Myofibril formation 0.018384589 9.5 NaN DES;MYOZ1
regorafenib Kinase inhibitor No MSN01 Down Natriuretic peptide receptor signaling 0.005875567 4 NaN NPPA;NPPB
regorafenib Kinase inhibitor No MSN05 Down Natriuretic peptide receptor signaling 0.006329822 6 NaN NPPA;NPPB
regorafenib Kinase inhibitor No MSN06 Down Natriuretic peptide receptor signaling 0.0055816 9 NaN NPPA;NPPB
regorafenib Kinase inhibitor No MSN08 Down Natriuretic peptide receptor signaling 0.006484773 6 NaN NPPA;NPPB
regorafenib Kinase inhibitor No MSN05 Down Non-vesicular phospholipid transport 0.008738546 7 NaN PITPNM1;PLTP
regorafenib Kinase inhibitor No MSN05 Up Notch receptor signaling 0.012093552 15 NaN DLK1;JAG1;NOTCH3
regorafenib Kinase inhibitor No MSN05 Down Osteonectin receptor signaling 0.002604019 3.5 NaN SPARC;SPOCK1
regorafenib Kinase inhibitor No MSN06 Down Osteonectin receptor signaling 0.00229214 4.5 NaN SPARC;SPOCK1
regorafenib Kinase inhibitor No MSN08 Down Osteonectin receptor signaling 0.00266871 4 NaN SPARC;SPOCK1
regorafenib Kinase inhibitor No MSN01 Up Osteopontin receptor signaling 0.025582216 26.5 NaN SPP1
regorafenib Kinase inhibitor No MSN05 Up Osteopontin receptor signaling 0.024435427 19 NaN SPP1
regorafenib Kinase inhibitor No MSN06 Up Osteopontin receptor signaling 0.025317572 18 NaN SPP1
regorafenib Kinase inhibitor No MSN08 Up Osteopontin receptor signaling 0.024788285 25 NaN SPP1
regorafenib Kinase inhibitor No MSN06 Up Platelet-derived growth factor receptor signaling 0.030213822 20 NaN PDGFRA;RGS5
regorafenib Kinase inhibitor No MSN08 Up Platelet-derived growth factor receptor signaling 0.002145083 11 NaN PDGFRA;PDGFRB;RGS5
regorafenib Kinase inhibitor No MSN05 Up Polyol pathway 0.003455479 9 NaN AKR1A1;SORD
regorafenib Kinase inhibitor No MSN06 Up Polyol pathway 0.003705518 7 NaN AKR1A1;SORD
regorafenib Kinase inhibitor No MSN08 Up Polyol pathway 0.003554482 13.5 NaN AKR1A1;SORD
regorafenib Kinase inhibitor No MSN06 Down Progesterone receptor signaling 0.019848271 12.5 NaN PGR
regorafenib Kinase inhibitor No MSN05 Down Prostaglandin PGF2 alpha receptor signaling 0.041896574 19 NaN PTGFR
regorafenib Kinase inhibitor No MSN06 Down Prostaglandin PGF2 alpha receptor signaling 0.039304304 17 NaN PTGFR
regorafenib Kinase inhibitor No MSN08 Down Prostaglandin PGF2 alpha receptor signaling 0.042414608 15 NaN PTGFR
regorafenib Kinase inhibitor No MSN01 Up Proteasomal regulatory particle organization 0.012580282 21.5 NaN PSMC4;PSMD14
regorafenib Kinase inhibitor No MSN05 Up Proteasomal regulatory particle organization 0.011520133 13.5 NaN PSMC4;PSMD14
regorafenib Kinase inhibitor No MSN06 Up Proteasomal regulatory particle organization 0.012331868 13 NaN PSMC4;PSMD14
regorafenib Kinase inhibitor No MSN08 Up Proteasomal regulatory particle organization 0.011841806 20.5 NaN PSMC4;PSMD14
regorafenib Kinase inhibitor No MSN01 Up Protein folding in mitochondria 0.001923604 13 NaN HSPD1;PPIF
regorafenib Kinase inhibitor No MSN06 Down Retinol metabolism 0.001904718 3 NaN RDH10;RPE65;STRA6
regorafenib Kinase inhibitor No MSN08 Down Retinol metabolism 0.03055135 12 NaN RDH10;STRA6
regorafenib Kinase inhibitor No MSN01 Down Serine and glycine metabolism 4.95E-05 1 NaN PHGDH;PSAT1;SHMT2;SLC1A5
regorafenib Kinase inhibitor No MSN05 Down Serine and glycine metabolism 0.001363561 2 NaN PHGDH;PSAT1;SHMT2
regorafenib Kinase inhibitor No MSN06 Down Serine and glycine metabolism 0.019170669 11 NaN PHGDH;SHMT2
regorafenib Kinase inhibitor No MSN08 Down Serine and glycine metabolism 0.001413291 3 NaN PHGDH;PSAT1;SHMT2
regorafenib Kinase inhibitor No MSN01 Down Serotonin inactivation 0.040341633 14 NaN MAOA
regorafenib Kinase inhibitor No MSN05 Down Serotonin inactivation 0.041896574 19 NaN MAOA
regorafenib Kinase inhibitor No MSN06 Down Serotonin inactivation 0.039304304 17 NaN MAOA
regorafenib Kinase inhibitor No MSN08 Down Serotonin inactivation 0.042414608 15 NaN MAOA
regorafenib Kinase inhibitor No MSN01 Up Sister chromatid attachment to mitotic spindle 0.000652251 10.5 NaN NUF2;TACC3
regorafenib Kinase inhibitor No MSN05 Up Sister chromatid attachment to mitotic spindle 0.048275867 24 NaN NUF2
regorafenib Kinase inhibitor No MSN08 Up Sister chromatid attachment to mitotic spindle 0.000612326 9 NaN NUF2;TACC3
regorafenib Kinase inhibitor No MSN01 Up Sister chromatid segregation 0.000312969 8.5 NaN ESPL1;PTTG1;TOP2A
regorafenib Kinase inhibitor No MSN05 Up Sister chromatid segregation 0.000273321 7 NaN ESPL1;PTTG1;TOP2A
regorafenib Kinase inhibitor No MSN06 Up Sister chromatid segregation 0.000303507 5 NaN ESPL1;PTTG1;TOP2A
regorafenib Kinase inhibitor No MSN08 Up Sister chromatid segregation 0.000285148 8 NaN ESPL1;PTTG1;TOP2A
regorafenib Kinase inhibitor No MSN05 Down Thrombospondin receptor signaling 0.002604019 3.5 NaN THBS1;THBS4
regorafenib Kinase inhibitor No MSN06 Down Thrombospondin receptor signaling 0.00229214 4.5 NaN THBS1;THBS4
regorafenib Kinase inhibitor No MSN01 Down Tropoelastin synthesis 0.020377558 10 NaN ELN
regorafenib Kinase inhibitor No MSN05 Down Tropoelastin synthesis 0.021171489 11.5 NaN ELN
regorafenib Kinase inhibitor No MSN06 Down Tropoelastin synthesis 0.019848271 12.5 NaN ELN
regorafenib Kinase inhibitor No MSN08 Down Tropoelastin synthesis 0.021436133 11 NaN ELN
regorafenib Kinase inhibitor No MSN01 Down Vasoactive intestinal peptide receptor signaling 0.040341633 14 NaN VIPR1
regorafenib Kinase inhibitor No MSN05 Down Vasoactive intestinal peptide receptor signaling 0.041896574 19 NaN VIPR1
regorafenib Kinase inhibitor No MSN08 Down Vasoactive intestinal peptide receptor signaling 0.042414608 15 NaN VIPR1
regorafenib Kinase inhibitor No MSN05 Down Versican receptor signaling 0.041896574 19 NaN VCAN
regorafenib Kinase inhibitor No MSN05 Down Versican synthesis 0.021171489 11.5 NaN VCAN
regorafenib Kinase inhibitor No MSN05 Up WNT-Beta-catenin signaling pathway 0.019844862 16 NaN CTHRC1;DKK2;FRZB;SFRP5;WNT2
regorafenib Kinase inhibitor No MSN06 Up WNT-Beta-catenin signaling pathway 0.001120405 6 NaN APCDD1;CTHRC1;FRZB;PAX6;SFRP4;SFRP5;WNT2
regorafenib Kinase inhibitor No MSN08 Up WNT-Beta-catenin signaling pathway 0.000990707 10 NaN APCDD1;CTHRC1;DACT1;DKK2;FRZB;SFRP5;WNT2
regorafenib Kinase inhibitor No MSN01 Down Z-disc organization 0.000252154 2 NaN CSRP3;DES;MYOZ1;PDLIM3
regorafenib Kinase inhibitor No MSN05 Down Z-disc organization 0.004279574 5 NaN DES;MYOZ1;PDLIM3
regorafenib Kinase inhibitor No MSN08 Down Z-disc organization 0.00030602 1 NaN CSRP3;DES;MYOZ1;PDLIM3
regorafenib Kinase inhibitor No MSN05 Up Aggrecan synthesis 0.024435427 19 NaN ACAN
regorafenib Kinase inhibitor No MSN06 Up Aggrecan synthesis 0.025317572 18 NaN ACAN
regorafenib Kinase inhibitor No MSN08 Up Aggrecan synthesis 0.024788285 25 NaN ACAN
regorafenib Kinase inhibitor No MSN01 Up Albumin mediated blood protein transport 0.025582216 26.5 NaN ALB
regorafenib Kinase inhibitor No MSN01 Down Antigen presentation via MHC class I molecules 0.016704296 8 NaN HLA-B;HLA-C
regorafenib Kinase inhibitor No MSN05 Down Antigen presentation via MHC class I molecules 0.017957896 9.5 NaN HLA-B;HLA-C
regorafenib Kinase inhibitor No MSN06 Down Antigen presentation via MHC class I molecules 0.000835187 2 NaN HLA-A;HLA-B;HLA-C
regorafenib Kinase inhibitor No MSN08 Down Antigen presentation via MHC class I molecules 0.018384589 9.5 NaN HLA-B;HLA-C
regorafenib Kinase inhibitor No MSN01 Up Apoptosome assembly 0.006197282 17 NaN BAG3;CDC6
regorafenib Kinase inhibitor No MSN01 Down Aspartate and arginine metabolism 0.016704296 8 NaN ARG2;SLC7A1
regorafenib Kinase inhibitor No MSN06 Down Betaglycan signaling 0.003770283 7.5 NaN SMAD6;TGFBR3
regorafenib Kinase inhibitor No MSN05 Up Biglycan synthesis 0.024435427 19 NaN BGN
regorafenib Kinase inhibitor No MSN01 Up Centrosome maturation 0.000176562 7 NaN AURKA;CDC25B;PLK1;TPX2
regorafenib Kinase inhibitor No MSN05 Up Centrosome maturation 0.002695833 8 NaN AURKA;PLK1;TPX2
regorafenib Kinase inhibitor No MSN06 Up Centrosome maturation 0.035660258 21 NaN PLK1;TPX2
regorafenib Kinase inhibitor No MSN08 Up Centrosome maturation 0.002807996 12 NaN AURKA;PLK1;TPX2
regorafenib Kinase inhibitor No MSN01 Up Centrosome separation 7.50E-10 1 NaN AURKA;CCNB1;CDK1;ESPL1;KIF11;NEK2;SPAG5
regorafenib Kinase inhibitor No MSN05 Up Centrosome separation 5.44E-10 2 NaN AURKA;CCNB1;CDK1;ESPL1;KIF11;NEK2;SPAG5
regorafenib Kinase inhibitor No MSN06 Up Centrosome separation 2.28E-06 2 NaN CCNB1;ESPL1;KIF11;NEK2;SPAG5
regorafenib Kinase inhibitor No MSN08 Up Centrosome separation 6.01E-10 1 NaN AURKA;CCNB1;CDK1;ESPL1;KIF11;NEK2;SPAG5
regorafenib Kinase inhibitor No MSN01 Up Chaperone-mediated autophagy 0.000652251 10.5 NaN HSP90AA1;HSPA8
regorafenib Kinase inhibitor No MSN05 Up Chaperone-mediated autophagy 0.048275867 24 NaN HSPA8
regorafenib Kinase inhibitor No MSN06 Up Chaperone-mediated autophagy 0.049996342 22.5 NaN HSPA8
regorafenib Kinase inhibitor No MSN01 Up Cholesterol synthesis 3.89E-07 3 NaN DHCR24;DHCR7;FDPS;HMGCR;HMGCS1;MVD;NSDHL
regorafenib Kinase inhibitor No MSN05 Up Cholesterol synthesis 3.79E-15 1 NaN CYP51A1;DHCR24;DHCR7;FDFT1;FDPS;HMGCR;HMGCS1;LSS;MSMO1;MVD;NSDHL;SQLE
regorafenib Kinase inhibitor No MSN06 Up Cholesterol synthesis 5.81E-15 1 NaN CYP51A1;DHCR24;DHCR7;FDFT1;FDPS;HMGCR;HMGCS1;LSS;MSMO1;MVD;NSDHL;SQLE
regorafenib Kinase inhibitor No MSN08 Up Cholesterol synthesis 1.26E-08 2 NaN DHCR24;DHCR7;FDFT1;FDPS;HMGCR;HMGCS1;MVD;NSDHL
regorafenib Kinase inhibitor No MSN01 Up Collagen fibril organization by fibril-associated bridges 0.000312969 8.5 NaN COL14A1;COL9A2;COL9A3
regorafenib Kinase inhibitor No MSN05 Up Collagen fibril organization by fibril-associated bridges 0.008362857 12 NaN COL9A2;COL9A3
regorafenib Kinase inhibitor No MSN06 Up Collagen fibril organization by fibril-associated bridges 0.008957388 10.5 NaN COL9A2;COL9A3
regorafenib Kinase inhibitor No MSN08 Up Collagen fibril organization by fibril-associated bridges 0.008598393 18 NaN COL9A2;COL9A3
regorafenib Kinase inhibitor No MSN01 Up Contractile ring constriction 0.000159506 6 NaN ANLN;ECT2;MYH14
regorafenib Kinase inhibitor No MSN05 Up Contractile ring constriction 0.005666345 10.5 NaN ANLN;MYH14
regorafenib Kinase inhibitor No MSN06 Up Contractile ring constriction 0.006072761 9 NaN ANLN;MYH14
regorafenib Kinase inhibitor No MSN08 Up Contractile ring constriction 0.00014524 7 NaN ANLN;ECT2;MYH14
regorafenib Kinase inhibitor No MSN01 Up Contractile ring formation 0.006197282 17 NaN MYH14;RACGAP1
regorafenib Kinase inhibitor No MSN05 Up Contractile ring formation 0.005666345 10.5 NaN MYH14;RACGAP1
regorafenib Kinase inhibitor No MSN08 Up Contractile ring formation 0.005827311 15.5 NaN MYH14;RACGAP1
regorafenib Kinase inhibitor No MSN01 Up Cytosolic protein folding 0.025582216 26.5 NaN HSP90AA1
regorafenib Kinase inhibitor No MSN01 Up Decorin synthesis 0.025582216 26.5 NaN DCN
regorafenib Kinase inhibitor No MSN05 Up Decorin synthesis 0.024435427 19 NaN DCN
regorafenib Kinase inhibitor No MSN06 Up Decorin synthesis 0.025317572 18 NaN DCN
regorafenib Kinase inhibitor No MSN08 Up Decorin synthesis 0.024788285 25 NaN DCN
regorafenib Kinase inhibitor No MSN01 Up Desaturation of fatty acids 0.012580282 21.5 NaN FADS2;SCD
regorafenib Kinase inhibitor No MSN05 Up Desaturation of fatty acids 0.011520133 13.5 NaN FADS2;SCD
regorafenib Kinase inhibitor No MSN06 Up Desaturation of fatty acids 0.012331868 13 NaN FADS2;SCD
regorafenib Kinase inhibitor No MSN08 Up Desaturation of fatty acids 0.011841806 20.5 NaN FADS2;SCD
regorafenib Kinase inhibitor No MSN01 Up Equatorial RhoA activation 0.003782172 15 NaN ECT2;KIF23
regorafenib Kinase inhibitor No MSN08 Up Equatorial RhoA activation 0.003554482 13.5 NaN ECT2;KIF23
prednisolone Glucocorticoid Yes MSN02 Up Acetylcholine-mediated control of postsynaptic potential 0.002291272 1 NaN CHRNA1;UTRN
prednisolone Glucocorticoid Yes MSN01 Up Actin filament bundling and crosslinking 0.002124398 2 NaN FHOD1;FLNB;SYNPO;SYNPO2
prednisolone Glucocorticoid Yes MSN02 Down Actin filament bundling and crosslinking 0.002187303 9 NaN ACTN1;ACTN4;PLS3;SYNPO;TAGLN
prednisolone Glucocorticoid Yes MSN02 Up Albumin mediated blood protein transport 0.010673959 3.5 NaN ALB
prednisolone Glucocorticoid Yes MSN02 Down Alternative complement pathway 0.012307779 18.5 NaN C1S;CFH
prednisolone Glucocorticoid Yes MSN06 Down Androgen receptor signaling 0.043622809 18.5 NaN AR
prednisolone Glucocorticoid Yes MSN09 Down Base excision repair 0.000932089 14 NaN EME1;FEN1;NEIL3;PCNA;POLQ
prednisolone Glucocorticoid Yes MSN06 Up Biglycan synthesis 0.022494707 9 NaN BGN
prednisolone Glucocorticoid Yes MSN01 Down Biglycan synthesis 0.023641496 19 NaN BGN
prednisolone Glucocorticoid Yes MSN02 Down Biglycan synthesis 0.036432604 27.5 NaN BGN
prednisolone Glucocorticoid Yes MSN05 Down Biglycan synthesis 0.022230064 18 NaN BGN
prednisolone Glucocorticoid Yes MSN08 Down Biglycan synthesis 0.020465773 23.5 NaN BGN
prednisolone Glucocorticoid Yes MSN01 Up Calcitonin receptor signaling 0.042414608 10.5 NaN RAMP1
prednisolone Glucocorticoid Yes MSN02 Up Cardiomyocyte depolarization during action potential 0.010673959 3.5 NaN SCN5A
prednisolone Glucocorticoid Yes MSN08 Down Cardiomyocyte pacemaker current generation 0.010765432 18.5 NaN CACNA1G;HCN4
prednisolone Glucocorticoid Yes MSN09 Up Cardiomyocyte repolarization during action potential and hyperpolarization 0.022717669 7 NaN KCNJ12;KCNJ2
prednisolone Glucocorticoid Yes MSN09 Up Caveolin-mediated endocytosis 0.04996016 16 NaN CAV1
prednisolone Glucocorticoid Yes MSN02 Down CCN intercellular signaling protein family receptor signaling 0.00045452 4 NaN CTGF;CYR61;WISP1
prednisolone Glucocorticoid Yes MSN05 Down CD44-Mediated leukocyte rolling 0.043967869 26 NaN CD44
prednisolone Glucocorticoid Yes MSN08 Up Cell cycle arrest in response to DNA damage 0.021145298 11 NaN CDKN1A;GADD45A;MDM2
prednisolone Glucocorticoid Yes MSN09 Down Cell cycle arrest in response to DNA damage 0.004004263 20 NaN CHEK2;FBXO5;H2AFX;UHRF1
prednisolone Glucocorticoid Yes MSN06 Down Cellular cholesterol uptake and efflux 0.032195057 15 NaN SCARA3;VLDLR
prednisolone Glucocorticoid Yes MSN01 Up Cellular iron uptake and export 0.03055135 9 NaN RASD1;SLC39A14
prednisolone Glucocorticoid Yes MSN05 Up Cellular iron uptake and export 0.033150099 12 NaN RASD1;SLC39A14
prednisolone Glucocorticoid Yes MSN08 Up Cellular iron uptake and export 0.003656435 6 NaN RASD1;SLC39A14;TFRC
prednisolone Glucocorticoid Yes MSN09 Up Cellular iron uptake and export 0.019689026 6 NaN RASD1;SLC39A14
prednisolone Glucocorticoid Yes MSN09 Down Centrosome duplication 0.031104825 30 NaN CCNF;PLK4;STIL
prednisolone Glucocorticoid Yes MSN01 Down Centrosome maturation 0.031435723 23.5 NaN PLK1;TPX2
prednisolone Glucocorticoid Yes MSN05 Down Centrosome maturation 0.02804976 22.5 NaN PLK1;TPX2
prednisolone Glucocorticoid Yes MSN06 Down Centrosome maturation 0.027637833 13 NaN PLK1;TPX2
prednisolone Glucocorticoid Yes MSN08 Down Centrosome maturation 7.44E-05 7.5 NaN AURKA;CDC25B;PLK1;TPX2
prednisolone Glucocorticoid Yes MSN09 Down Centrosome maturation 0.000242684 9.5 NaN AURKA;BORA;PLK1;TPX2
prednisolone Glucocorticoid Yes MSN09 Down Centrosome organization 0.002716449 18 NaN ASPM;NEK2;PLK4;POC1A;STIL;TACC3;WDR62
prednisolone Glucocorticoid Yes MSN01 Down Centrosome separation 5.73E-05 4 NaN CCNB1;CDK1;KIF11;SPAG5
prednisolone Glucocorticoid Yes MSN05 Down Centrosome separation 1.20E-06 3 NaN CCNB1;CDK1;ESPL1;KIF11;SPAG5
prednisolone Glucocorticoid Yes MSN06 Down Centrosome separation 1.15E-06 2 NaN CCNB1;CDK1;KIF11;NEK2;SPAG5
prednisolone Glucocorticoid Yes MSN08 Down Centrosome separation 1.35E-08 3 NaN AURKA;CCNB1;CDK1;ESPL1;KIF11;SPAG5
prednisolone Glucocorticoid Yes MSN09 Down Centrosome separation 1.34E-09 4 NaN AURKA;CCNB1;CDK1;ESPL1;KIF11;NEK2;SPAG5
prednisolone Glucocorticoid Yes MSN09 Up Chaperone mediated protein folding in ER 0.044399281 13 NaN ERO1A;ERO1B
prednisolone Glucocorticoid Yes MSN08 Up Chaperone-mediated autophagy 0.049308339 14.5 NaN HSPA8
prednisolone Glucocorticoid Yes MSN08 Up Cholesterol synthesis 0.000106652 2 NaN CYP51A1;HMGCR;HMGCS1;MSMO1;SQLE
prednisolone Glucocorticoid Yes MSN09 Up Cholesterol synthesis 0.004409512 3 NaN DHCR24;HMGCS1;MSMO1
prednisolone Glucocorticoid Yes MSN06 Up Chondroitin sulfate and dermatan sulfate synthesis 0.00982368 4 NaN SERPIND1;SOX9
prednisolone Glucocorticoid Yes MSN05 Up Citric acid cycle 0.033150099 12 NaN IDH2;PDHA1
prednisolone Glucocorticoid Yes MSN09 Up Class switch recombination 0.040400304 12 NaN BCL6;IRF8
prednisolone Glucocorticoid Yes MSN02 Down Classical complement pathway 0.024624794 23.5 NaN C1R;C1S
prednisolone Glucocorticoid Yes MSN02 Down Collagen fiber crosslinking 0.012307779 18.5 NaN LOX;PXDN
prednisolone Glucocorticoid Yes MSN08 Up Collagen fibril organization by fibril-associated bridges 0.0087173 8 NaN COL12A1;COL9A2
prednisolone Glucocorticoid Yes MSN01 Down Collagen fibril organization by fibril-associated bridges 0.007844056 11 NaN COL14A1;COL19A1
prednisolone Glucocorticoid Yes MSN02 Down Collagen fibril organization by fibril-associated bridges 0.000884463 6 NaN COL12A1;COL14A1;COL9A3
prednisolone Glucocorticoid Yes MSN08 Down Collagen fibril organization by fibril-associated bridges 0.005925252 16.5 NaN COL14A1;COL9A1
prednisolone Glucocorticoid Yes MSN01 Down Contractile ring constriction 0.005312003 7.5 NaN ANLN;ECT2
prednisolone Glucocorticoid Yes MSN02 Down Contractile ring constriction 0.012307779 18.5 NaN ANLN;MYLK
prednisolone Glucocorticoid Yes MSN05 Down Contractile ring constriction 0.004708979 11.5 NaN ANLN;ECT2
prednisolone Glucocorticoid Yes MSN09 Down Contractile ring constriction 0.007281219 22 NaN ANLN;ECT2
prednisolone Glucocorticoid Yes MSN06 Up Decorin synthesis 0.022494707 9 NaN DCN
prednisolone Glucocorticoid Yes MSN02 Down Decorin synthesis 0.036432604 27.5 NaN DCN
prednisolone Glucocorticoid Yes MSN05 Down Decorin synthesis 0.022230064 18 NaN DCN
prednisolone Glucocorticoid Yes MSN05 Down DNA cleavage 0.023717846 21 NaN FEN1;HMGB2
prednisolone Glucocorticoid Yes MSN08 Down DNA cleavage 0.02030943 20.5 NaN FEN1;HMGB2
prednisolone Glucocorticoid Yes MSN08 Down DNA replication elongation 3.44E-09 2 NaN MCM2;MCM4;MCM5;MCM7;PCNA
prednisolone Glucocorticoid Yes MSN09 Down DNA replication elongation 1.61E-08 5 NaN MCM2;MCM4;MCM5;MCM7;PCNA
prednisolone Glucocorticoid Yes MSN08 Down DNA replication initiation 7.22E-13 1 NaN CDC45;CDC6;GINS1;GINS2;MCM10;MCM2;MCM3;MCM4;MCM5;MCM6;MCM7
prednisolone Glucocorticoid Yes MSN09 Down DNA replication initiation 4.16E-16 1 NaN CDC45;CDC6;GINS1;GINS2;GINS4;MCM10;MCM2;MCM4;MCM5;MCM6;MCM7;ORC1;ORC6;TICRR
prednisolone Glucocorticoid Yes MSN06 Up Endogenous control of complement activity 0.00481941 3 NaN CFH;CFI
prednisolone Glucocorticoid Yes MSN02 Down Endogenous control of complement activity 0.012307779 18.5 NaN CFH;CFI
prednisolone Glucocorticoid Yes MSN06 Up Epidermal growth factor receptor signaling 0.014285498 5 NaN AREG;ERRFI1;LRIG2
prednisolone Glucocorticoid Yes MSN01 Down Equatorial RhoA activation 0.003237663 6 NaN ECT2;KIF23
prednisolone Glucocorticoid Yes MSN05 Down Equatorial RhoA activation 0.002867401 10 NaN ECT2;KIF23
prednisolone Glucocorticoid Yes MSN09 Down Equatorial RhoA activation 0.00445029 21 NaN ECT2;KIF23
prednisolone Glucocorticoid Yes MSN01 Down Mitotic spindle assembly 2.47E-07 2 NaN CKAP2;DLGAP5;NUSAP1;TACC3;TPX2;TTK
prednisolone Glucocorticoid Yes MSN02 Down Mitotic spindle assembly 0.010454835 15.5 NaN NUSAP1;TACC3;TPX2
prednisolone Glucocorticoid Yes MSN05 Down Mitotic spindle assembly 1.71E-07 2 NaN CKAP2;DLGAP5;NUSAP1;TACC3;TPX2;TTK
prednisolone Glucocorticoid Yes MSN06 Down Mitotic spindle assembly 5.58E-06 3 NaN CKAP2;DLGAP5;NUSAP1;TPX2;TTK
prednisolone Glucocorticoid Yes MSN08 Down Mitotic spindle assembly 0.000105704 10 NaN DLGAP5;NUSAP1;TACC3;TPX2
prednisolone Glucocorticoid Yes MSN09 Down Mitotic spindle assembly 6.39E-07 7 NaN CKAP2;DLGAP5;NUSAP1;TACC3;TPX2;TTK
prednisolone Glucocorticoid Yes MSN01 Down Mitotic spindle disassembly 0.023641496 19 NaN CDK1
prednisolone Glucocorticoid Yes MSN05 Down Mitotic spindle disassembly 0.022230064 18 NaN CDK1
prednisolone Glucocorticoid Yes MSN06 Down Mitotic spindle disassembly 0.022053634 9.5 NaN CDK1
prednisolone Glucocorticoid Yes MSN08 Down Mitotic spindle disassembly 0.020465773 23.5 NaN CDK1
prednisolone Glucocorticoid Yes MSN09 Down Mitotic spindle disassembly 0.027787579 28 NaN CDK1
prednisolone Glucocorticoid Yes MSN01 Up Natriuretic peptide receptor signaling 0.006484773 4 NaN NPPA;NPPB
prednisolone Glucocorticoid Yes MSN05 Up Natriuretic peptide receptor signaling 0.007067944 3 NaN NPPA;NPPB
prednisolone Glucocorticoid Yes MSN08 Up Natriuretic peptide receptor signaling 0.000291184 3 NaN NPPA;NPPB;NPR3
prednisolone Glucocorticoid Yes MSN09 Up Natriuretic peptide receptor signaling 0.004093177 2 NaN NPPA;NPPB
prednisolone Glucocorticoid Yes MSN02 Down Natriuretic peptide receptor signaling 0.018019436 21.5 NaN NPPA;NPPB
prednisolone Glucocorticoid Yes MSN06 Down Neuregulin receptor signaling 0.023366841 11 NaN ERBB4;SH3TC2
prednisolone Glucocorticoid Yes MSN02 Down Notch receptor signaling 0.005289729 12 NaN DLK1;JAG1;LFNG;NOTCH3
prednisolone Glucocorticoid Yes MSN01 Down Nuclear envelope maintenance 0.007844056 11 NaN LMNB1;TMPO
prednisolone Glucocorticoid Yes MSN05 Down Nuclear envelope maintenance 0.006960163 13.5 NaN LMNB1;TMPO
prednisolone Glucocorticoid Yes MSN01 Down Nuclear intermediate filaments 0.007844056 11 NaN LMNB1;TMPO
prednisolone Glucocorticoid Yes MSN05 Down Nuclear intermediate filaments 0.006960163 13.5 NaN LMNB1;TMPO
prednisolone Glucocorticoid Yes MSN08 Down Nuclear intermediate filaments 0.005925252 16.5 NaN LMNB1;LMNB2
prednisolone Glucocorticoid Yes MSN09 Down Nuclear intermediate filaments 0.01072213 24 NaN LMNB1;LMNB2
prednisolone Glucocorticoid Yes MSN08 Down Nucleosome assembly 0.000935608 13 NaN ASF1B;CHAF1A;CHAF1B;H2AFZ
prednisolone Glucocorticoid Yes MSN09 Down Nucleosome assembly 0.002879543 19 NaN ASF1B;CHAF1A;CHAF1B;H2AFZ
prednisolone Glucocorticoid Yes MSN06 Up Osteonectin receptor signaling 0.002935166 2 NaN SMOC2;SPARC
prednisolone Glucocorticoid Yes MSN02 Down Osteonectin receptor signaling 0.000186869 2.5 NaN SMOC2;SPARC;SPOCK1
prednisolone Glucocorticoid Yes MSN05 Down Osteopontin receptor signaling 0.022230064 18 NaN SPP1
prednisolone Glucocorticoid Yes MSN08 Down Osteopontin receptor signaling 0.020465773 23.5 NaN SPP1
prednisolone Glucocorticoid Yes MSN09 Down Osteopontin receptor signaling 0.027787579 28 NaN SPP1
prednisolone Glucocorticoid Yes MSN01 Up Perlecan synthesis 0.021436133 8 NaN HSPG2
prednisolone Glucocorticoid Yes MSN05 Up Perlecan synthesis 0.022406493 8 NaN HSPG2
prednisolone Glucocorticoid Yes MSN05 Up Phosphoglyceride biosynthesis 0.02407108 10 NaN PCYT2;PTDSS1
prednisolone Glucocorticoid Yes MSN06 Up Platelet-derived growth factor receptor signaling 0.024248529 11 NaN PDGFRA;PDGFRB
prednisolone Glucocorticoid Yes MSN01 Down Platelet-derived growth factor receptor signaling 0.026605409 22 NaN PDGFD;RGS5
prednisolone Glucocorticoid Yes MSN02 Down Platelet-derived growth factor receptor signaling 0.000467333 5 NaN PDGFB;PDGFRA;PDGFRB;TNK2
prednisolone Glucocorticoid Yes MSN02 Down Procollagen processing in the ER 0.003876672 10.5 NaN P3H1;SERPINH1
prednisolone Glucocorticoid Yes MSN02 Down Progesterone receptor signaling 0.036432604 27.5 NaN PGR
prednisolone Glucocorticoid Yes MSN05 Down Progesterone receptor signaling 0.022230064 18 NaN PGR
prednisolone Glucocorticoid Yes MSN06 Down Progesterone receptor signaling 0.022053634 9.5 NaN PGR
prednisolone Glucocorticoid Yes MSN09 Up Purinergic P1 receptor signaling 0.04996016 16 NaN ADORA1
prednisolone Glucocorticoid Yes MSN02 Down Pyrimidine synthesis and salvage 0.032051473 25 NaN TK1;TYMS
prednisolone Glucocorticoid Yes MSN06 Down Pyrimidine synthesis and salvage 0.012425035 7 NaN TK1;TYMS
prednisolone Glucocorticoid Yes MSN08 Down Pyrimidine synthesis and salvage 0.010765432 18.5 NaN TK1;TYMS
prednisolone Glucocorticoid Yes MSN09 Down Pyrimidine synthesis and salvage 0.019291933 25 NaN TK1;TYMS
prednisolone Glucocorticoid Yes MSN01 Down Restriction point 0.022108594 15 NaN CDK6;E2F1
prednisolone Glucocorticoid Yes MSN05 Up Retinol metabolism 0.033150099 12 NaN DHRS3;TTR
prednisolone Glucocorticoid Yes MSN08 Up Retinol metabolism 1.02E-05 1 NaN ALDH1A1;ALDH1A3;CYP26A1;DHRS3;RLBP1
prednisolone Glucocorticoid Yes MSN08 Down Ribonucleotide reduction 0.00123431 14 NaN RRM1;RRM2
prednisolone Glucocorticoid Yes MSN02 Up RIG-I-like receptor signaling 0.042022559 12 NaN MAVS
prednisolone Glucocorticoid Yes MSN06 Down Semaphorin signaling 0.006368335 6 NaN CRMP1;DPYSL4;SEMA3D;SEMA6A
prednisolone Glucocorticoid Yes MSN08 Down Serine and glycine metabolism 0.02030943 20.5 NaN AMT;PHGDH
prednisolone Glucocorticoid Yes MSN01 Up Serotonin inactivation 0.042414608 10.5 NaN MAOA
prednisolone Glucocorticoid Yes MSN02 Up Serotonin inactivation 0.021234916 6 NaN MAOA
prednisolone Glucocorticoid Yes MSN05 Up Serotonin inactivation 0.044312867 14.5 NaN MAOA
prednisolone Glucocorticoid Yes MSN06 Up Serotonin inactivation 0.044485342 13 NaN MAOA
prednisolone Glucocorticoid Yes MSN08 Up Serotonin inactivation 0.049308339 14.5 NaN MAOA
prednisolone Glucocorticoid Yes MSN09 Up Serotonin inactivation 0.033588983 10.5 NaN MAOA
prednisolone Glucocorticoid Yes MSN01 Down Sister chromatid attachment to mitotic spindle 0.000556884 5 NaN NUF2;TACC3
prednisolone Glucocorticoid Yes MSN05 Down Sister chromatid attachment to mitotic spindle 0.000492258 8 NaN NUF2;TACC3
prednisolone Glucocorticoid Yes MSN08 Down Sister chromatid attachment to mitotic spindle 0.040514466 28.5 NaN TACC3
prednisolone Glucocorticoid Yes MSN09 Down Sister chromatid attachment to mitotic spindle 0.000769766 13 NaN NUF2;TACC3
prednisolone Glucocorticoid Yes MSN01 Down Sister chromatid segregation 0.007844056 11 NaN PTTG1;TOP2A
prednisolone Glucocorticoid Yes MSN02 Down Sister chromatid segregation 0.018019436 21.5 NaN PTTG1;TOP2A
prednisolone Glucocorticoid Yes MSN05 Down Sister chromatid segregation 0.000206611 6 NaN ESPL1;PTTG1;TOP2A
prednisolone Glucocorticoid Yes MSN08 Down Sister chromatid segregation 0.000161702 11 NaN ESPL1;PTTG1;TOP2A
prednisolone Glucocorticoid Yes MSN09 Down Sister chromatid segregation 0.000399396 11 NaN ESPL1;PTTG1;TOP2A
prednisolone Glucocorticoid Yes MSN09 Down Telomere replication and maintenance 0.009096755 23 NaN EXO1;PIF1;RECQL4
prednisolone Glucocorticoid Yes MSN02 Up Thick myofilament organization 0.031684058 9 NaN TTN
prednisolone Glucocorticoid Yes MSN01 Up Thin myofilament organization 0.008950881 5 NaN ACTA1;TNNI3
prednisolone Glucocorticoid Yes MSN02 Down Thin myofilament organization 0.024624794 23.5 NaN ACTA1;TPM4
prednisolone Glucocorticoid Yes MSN02 Down Thrombospondin receptor signaling 0.000186869 2.5 NaN THBS1;THBS2;THBS4
prednisolone Glucocorticoid Yes MSN05 Down Thrombospondin receptor signaling 4.27E-05 5 NaN CD47;THBS1;THBS2
prednisolone Glucocorticoid Yes MSN08 Up Transcription termination 0.001832472 5 NaN PCF11;SETX
prednisolone Glucocorticoid Yes MSN02 Up Transmembrane glucose transport 0.042022559 12 NaN SLC2A1
prednisolone Glucocorticoid Yes MSN05 Up Transmembrane glucose transport 0.002912493 1 NaN SLC2A1;SLC2A4
prednisolone Glucocorticoid Yes MSN05 Up Tropoelastin synthesis 0.022406493 8 NaN ELN
prednisolone Glucocorticoid Yes MSN06 Up Tropoelastin synthesis 0.022494707 9 NaN ELN
prednisolone Glucocorticoid Yes MSN08 Up Tropoelastin synthesis 0.024964714 13 NaN ELN
prednisolone Glucocorticoid Yes MSN01 Down Tropoelastin synthesis 0.023641496 19 NaN ELN
prednisolone Glucocorticoid Yes MSN02 Down Tropoelastin synthesis 0.036432604 27.5 NaN ELN
prednisolone Glucocorticoid Yes MSN09 Up Vasoactive intestinal peptide receptor signaling 0.033588983 10.5 NaN VIPR2
prednisolone Glucocorticoid Yes MSN05 Down Vasoactive intestinal peptide receptor signaling 0.043967869 26 NaN VIPR1
prednisolone Glucocorticoid Yes MSN06 Down Vasoactive intestinal peptide receptor signaling 0.043622809 18.5 NaN VIPR1
prednisolone Glucocorticoid Yes MSN01 Down Versican receptor signaling 0.046726108 26.5 NaN VCAN
prednisolone Glucocorticoid Yes MSN08 Down Versican receptor signaling 0.040514466 28.5 NaN VCAN
prednisolone Glucocorticoid Yes MSN01 Down Versican synthesis 0.023641496 19 NaN VCAN
prednisolone Glucocorticoid Yes MSN08 Down Versican synthesis 0.020465773 23.5 NaN VCAN
prednisolone Glucocorticoid Yes MSN01 Up Water transmembrane transport 0.011766804 6 NaN AQP1;AQP10
prednisolone Glucocorticoid Yes MSN05 Up Water transmembrane transport 0.012808436 4 NaN AQP1;AQP10
prednisolone Glucocorticoid Yes MSN05 Up WNT-Beta-catenin signaling pathway 0.014145821 5 NaN AXIN2;DKK3;KREMEN1;SFRP5;WNT9A
prednisolone Glucocorticoid Yes MSN09 Up WNT-Beta-catenin signaling pathway 0.023026228 8 NaN AXIN2;DKK3;SFRP5;WNT9A
prednisolone Glucocorticoid Yes MSN01 Down Eukaryotic kinetochore dynamics 1.72E-12 1 NaN BUB1;CENPE;CENPF;CENPH;CENPU;MAD2L1;MIS18BP1;NDC80;NUF2;SKA2;SKA3;TTK;ZWINT
prednisolone Glucocorticoid Yes MSN05 Down Eukaryotic kinetochore dynamics 3.73E-10 1 NaN BUB1;CENPE;CENPF;CENPH;CENPU;MAD2L1;MIS18BP1;NDC80;NUF2;TTK;ZWINT
prednisolone Glucocorticoid Yes MSN06 Down Eukaryotic kinetochore dynamics 9.97E-08 1 NaN BUB1;CENPE;CENPF;CENPH;CENPU;NDC80;SPC24;TTK;ZWINT
prednisolone Glucocorticoid Yes MSN08 Down Eukaryotic kinetochore dynamics 1.01E-05 4 NaN BUB1;CENPF;CENPU;MAD2L1;NDC80;SPC24;ZWINT
prednisolone Glucocorticoid Yes MSN09 Down Eukaryotic kinetochore dynamics 6.51E-13 2 NaN BUB1;CENPE;CENPF;CENPH;CENPI;CENPU;KIF15;MAD2L1;NDC80;NUF2;SKA3;SPC24;TTK;ZWINT
prednisolone Glucocorticoid Yes MSN01 Up Extracellular matrix breakdown and membrane shedding by adamalysins 0.014121703 7 NaN ADAMTS14;ADAMTS5;ADAMTS8
prednisolone Glucocorticoid Yes MSN02 Up Extracellular matrix breakdown and membrane shedding by adamalysins 0.026758713 7 NaN ADAMTS14;ADAMTS5
prednisolone Glucocorticoid Yes MSN02 Down Extracellular matrix breakdown and membrane shedding by adamalysins 0.001500564 8 NaN ADAM12;ADAM19;ADAMTS12;ADAMTS2;ADAMTS7
prednisolone Glucocorticoid Yes MSN02 Down Extracellular matrix breakdown by heparanases and sulfatases 0.007566475 13 NaN SULF1;SULF2
prednisolone Glucocorticoid Yes MSN02 Down Extracellular matrix breakdown by matrix metalloproteases 0.04023116 30 NaN MMP14;MMP2
prednisolone Glucocorticoid Yes MSN09 Down Extracellular matrix breakdown by matrix metalloproteases 0.024353565 26 NaN MMP1;MMP2
prednisolone Glucocorticoid Yes MSN01 Down Fanconi anemia interstrand cross-link repair pathway 0.022739051 16 NaN BRCA2;BRIP1;FANCI
prednisolone Glucocorticoid Yes MSN05 Down Fanconi anemia interstrand cross-link repair pathway 0.019352519 15 NaN BRCA2;FANCI;USP1
prednisolone Glucocorticoid Yes MSN06 Down Fanconi anemia interstrand cross-link repair pathway 0.018950674 8 NaN BRCA2;FANCD2;UBE2T
prednisolone Glucocorticoid Yes MSN08 Down Fanconi anemia interstrand cross-link repair pathway 1.13E-05 5 NaN BRCA2;BRIP1;FANCA;FANCD2;FANCG;FANCI
prednisolone Glucocorticoid Yes MSN09 Down Fanconi anemia interstrand cross-link repair pathway 3.28E-07 6 NaN BRCA2;BRIP1;EME1;FANCA;FANCD2;FANCG;FANCI;UBE2T
prednisolone Glucocorticoid Yes MSN08 Up Fatty acid elongation 0.001156554 4 NaN ELOVL6;ELOVL7;HACD1
prednisolone Glucocorticoid Yes MSN05 Up Fatty acid omega-hydroxylation 0.022406493 8 NaN CYP2E1
prednisolone Glucocorticoid Yes MSN09 Up Fatty acid transfer between membranes 0.04996016 16 NaN FABP3
prednisolone Glucocorticoid Yes MSN06 Up Fibrillar collagen core structure organization 1.27E-06 1 NaN COL11A1;COL1A1;COL1A2;COL3A1;COL5A3
prednisolone Glucocorticoid Yes MSN02 Down Fibrillar collagen core structure organization 8.85E-09 1 NaN COL11A1;COL1A1;COL1A2;COL3A1;COL5A1;COL5A2;COL5A3
prednisolone Glucocorticoid Yes MSN08 Down Fibrillar collagen core structure organization 0.000912967 12 NaN COL1A2;COL2A1;COL3A1
prednisolone Glucocorticoid Yes MSN09 Down Fibrillar collagen core structure organization 0.002205632 16 NaN COL1A1;COL1A2;COL2A1
prednisolone Glucocorticoid Yes MSN06 Down Fibroblast growth factor receptor signaling 0.027637833 13 NaN FGF1;FGF7
prednisolone Glucocorticoid Yes MSN01 Down Fibulin receptor signaling 0.046726108 26.5 NaN FBLN1
prednisolone Glucocorticoid Yes MSN08 Down Fibulin receptor signaling 0.040514466 28.5 NaN FBLN1
prednisolone Glucocorticoid Yes MSN01 Down G2 M transition checkpoint 0.031435723 23.5 NaN CCNB1;CDK1
prednisolone Glucocorticoid Yes MSN05 Down G2 M transition checkpoint 0.02804976 22.5 NaN CCNB1;CDK1
prednisolone Glucocorticoid Yes MSN06 Down G2 M transition checkpoint 0.027637833 13 NaN CCNB1;CDK1
prednisolone Glucocorticoid Yes MSN08 Down G2 M transition checkpoint 7.44E-05 7.5 NaN CCNB1;CDC25B;CDC25C;CDK1
prednisolone Glucocorticoid Yes MSN09 Down G2 M transition checkpoint 0.000242684 9.5 NaN CCNB1;CDC25C;CDK1;CHEK2
prednisolone Glucocorticoid Yes MSN02 Up Galactose metabolism 0.042022559 12 NaN GALK1
prednisolone Glucocorticoid Yes MSN06 Down Gap junction organization 0.037023918 16 NaN GJA3;PANX2
prednisolone Glucocorticoid Yes MSN08 Down Gap junction organization 0.032279631 26 NaN GJA5;GJD2
prednisolone Glucocorticoid Yes MSN01 Down Glutamate and glutamine metabolism 0.036581377 25 NaN GLS;SLC38A2
prednisolone Glucocorticoid Yes MSN02 Down Glutamate and glutamine metabolism 0.010454835 15.5 NaN SLC1A5;SLC38A2;SLC7A5
prednisolone Glucocorticoid Yes MSN01 Up Glycogen synthesis and glycogenolysis 0.004431277 3 NaN GYS1;PPP1R3B;PYGM
prednisolone Glucocorticoid Yes MSN02 Up Glycogen synthesis and glycogenolysis 0.012296662 5 NaN AGL;PPP1R3B
prednisolone Glucocorticoid Yes MSN05 Up Glycogen synthesis and glycogenolysis 0.005015598 2 NaN AGL;GYG2;PPP1R3B
prednisolone Glucocorticoid Yes MSN09 Up Glycogen synthesis and glycogenolysis 0.02930283 9 NaN AGL;PPP1R3B
prednisolone Glucocorticoid Yes MSN05 Up Glyoxylate metabolism 0.044312867 14.5 NaN GRHPR
prednisolone Glucocorticoid Yes MSN06 Up Hepatocyte growth factor receptor signaling 0.044485342 13 NaN HGF
prednisolone Glucocorticoid Yes MSN06 Up HIF-1 receptor signaling pathway 0.016348087 6 NaN EGLN3;HIF1A
prednisolone Glucocorticoid Yes MSN08 Up HIF-1 receptor signaling pathway 0.019911463 10 NaN EGLN1;HIF1A
prednisolone Glucocorticoid Yes MSN09 Up HIF-1 receptor signaling pathway 0.009500113 4 NaN EGLN1;HIF1A
prednisolone Glucocorticoid Yes MSN05 Down Histamine metabolism 0.043967869 26 NaN HNMT
prednisolone Glucocorticoid Yes MSN08 Down Homologous recombination DSB repair 0.00237953 15 NaN BRCA2;PIF1;RAD51AP1;RECQL4;RMI2
prednisolone Glucocorticoid Yes MSN09 Down Homologous recombination DSB repair 0.001611497 15 NaN BRCA2;EXO1;PIF1;RAD51AP1;RECQL4;XRCC2
prednisolone Glucocorticoid Yes MSN01 Down Hyaluronan-mediated motility receptor signaling 0.023641496 19 NaN HMMR
prednisolone Glucocorticoid Yes MSN09 Down Hyaluronan-mediated motility receptor signaling 0.027787579 28 NaN HMMR
prednisolone Glucocorticoid Yes MSN02 Down Inhibition of amyloid aggregation, amyloid degradation and uptake 0.003876672 10.5 NaN MME;PLAT
prednisolone Glucocorticoid Yes MSN09 Up Inhibition of apoptosis 0.016845643 5 NaN CFLAR;PEA15
prednisolone Glucocorticoid Yes MSN05 Down Inositol metabolism and transport 0.043967869 26 NaN SLC5A3
prednisolone Glucocorticoid Yes MSN06 Down Insulin receptor signaling 0.042110321 17 NaN IRS1;PIK3C2B
prednisolone Glucocorticoid Yes MSN09 Up Intracellular bridge assembly 0.04996016 16 NaN NEK7
prednisolone Glucocorticoid Yes MSN05 Down Intracellular bridge assembly 0.001455058 9 NaN INCENP;KIF23
prednisolone Glucocorticoid Yes MSN09 Down Intracellular bridge assembly 0.002266783 17 NaN INCENP;KIF23
prednisolone Glucocorticoid Yes MSN01 Up Lipid droplet biogenesis 3.91E-05 1 NaN FITM2;PLIN2;PLIN4;PLIN5
prednisolone Glucocorticoid Yes MSN02 Up Lipid droplet biogenesis 0.004807987 2 NaN PLIN2;PLIN5
prednisolone Glucocorticoid Yes MSN05 Up Lipid droplet biogenesis 0.019986419 6 NaN PLIN2;PLIN5
prednisolone Glucocorticoid Yes MSN06 Up Lipid droplet biogenesis 0.020134923 7 NaN PLIN2;PLIN5
prednisolone Glucocorticoid Yes MSN08 Up Lipid droplet biogenesis 0.024483872 12 NaN PLIN2;PLIN5
prednisolone Glucocorticoid Yes MSN09 Up Lipid droplet biogenesis 0.000525812 1 NaN FITM2;PLIN2;PLIN5
prednisolone Glucocorticoid Yes MSN02 Up Lipid droplet mitochondria interaction 0.031684058 9 NaN PLIN2
prednisolone Glucocorticoid Yes MSN09 Up Lipid droplet mitochondria interaction 0.04996016 16 NaN PLIN2
prednisolone Glucocorticoid Yes MSN02 Up Lysine metabolism 0.031684058 9 NaN AASS
prednisolone Glucocorticoid Yes MSN01 Down Metaphase to anaphase checkpoint 9.36E-07 3 NaN BUB1;BUB1B;CCNB2;CDC20;CENPE;MAD2L1;PTTG1;TTK
prednisolone Glucocorticoid Yes MSN05 Down Metaphase to anaphase checkpoint 7.95E-06 4 NaN BUB1;BUB1B;CDC20;CENPE;MAD2L1;PTTG1;TTK
prednisolone Glucocorticoid Yes MSN06 Down Metaphase to anaphase checkpoint 7.54E-06 4 NaN BUB1;BUB1B;CCNB2;CDC20;CENPE;MXD3;TTK
prednisolone Glucocorticoid Yes MSN08 Down Metaphase to anaphase checkpoint 5.73E-05 6 NaN BUB1;BUB1B;CCNB2;CDC20;MAD2L1;PTTG1
prednisolone Glucocorticoid Yes MSN09 Down Metaphase to anaphase checkpoint 1.04E-09 3 NaN BUB1;BUB1B;CCNB2;CDC20;CENPE;FBXO5;MAD2L1;MASTL;MXD3;PTTG1;TTK
prednisolone Glucocorticoid Yes MSN06 Up Microfibril scaffold organization 0.044485342 13 NaN FBN1
prednisolone Glucocorticoid Yes MSN02 Down Microfibril scaffold organization 0.001324238 7 NaN FBN1;MFAP2
prednisolone Glucocorticoid Yes MSN08 Down Microfibril scaffold organization 0.040514466 28.5 NaN MFAP2
prednisolone Glucocorticoid Yes MSN01 Down Microtubule destabilization 0.007844056 11 NaN KIF2C;STMN1
prednisolone Glucocorticoid Yes MSN08 Up Microtubule stabilization 0.015743705 9 NaN MAP1B;MAPRE2
prednisolone Glucocorticoid Yes MSN05 Down Mineralocorticoid receptor signaling 0.043967869 26 NaN NR3C2
prednisolone Glucocorticoid Yes MSN01 Down Mitotic chromosome condensation 0.010811186 14 NaN SMC2;SMC4
prednisolone Glucocorticoid Yes MSN05 Down Mitotic chromosome condensation 0.000355631 7 NaN INCENP;SMC2;SMC4
prednisolone Glucocorticoid Yes MSN09 Down Mitotic chromosome condensation 0.000684569 12 NaN INCENP;NCAPG2;SMC4
prednisolone Glucocorticoid Yes MSN01 Down Mitotic H3 phosphorylation and dephosphorylation 0.005312003 7.5 NaN AURKB;CCNA2
prednisolone Glucocorticoid Yes MSN05 Down Mitotic H3 phosphorylation and dephosphorylation 0.004708979 11.5 NaN CCNA2;INCENP
prednisolone Glucocorticoid Yes MSN06 Down Mitotic H3 phosphorylation and dephosphorylation 0.004636036 5 NaN CCNA2;INCENP
prednisolone Glucocorticoid Yes MSN08 Down Mitotic H3 phosphorylation and dephosphorylation 8.21E-05 9 NaN AURKB;CCNA2;INCENP
prednisolone Glucocorticoid Yes MSN09 Down Mitotic H3 phosphorylation and dephosphorylation 0.000203897 8 NaN AURKB;CCNA2;INCENP
prednisolone Glucocorticoid Yes MSN02 Down WNT-Beta-catenin signaling pathway 0.008408768 14 NaN CTHRC1;DACT1;DKK2;FRZB;FZD7;SFRP1;SFRP2
prednisolone Glucocorticoid Yes MSN01 Up Z-disc organization 0.04507252 12 NaN CSRP3;TCAP
prednisolone Glucocorticoid Yes MSN06 Up Z-disc organization 0.049160367 15 NaN NEXN;TCAP
prednisolone Glucocorticoid Yes MSN08 Up Z-disc organization 0.006773923 7 NaN DNAJB6;NEXN;TCAP
ponatinib Kinase inhibitor Yes MSN01 Down Z-disc organization 4.05E-05 2 NaN CSRP3;DES;MYPN;PDLIM3;TCAP
ponatinib Kinase inhibitor Yes MSN02 Down Z-disc organization 0.000575652 2 NaN CSRP3;MYPN;PDLIM3;TCAP
ponatinib Kinase inhibitor Yes MSN06 Down Z-disc organization 0.000778844 2 NaN CSRP3;DES;PDLIM3;TCAP
ponatinib Kinase inhibitor Yes MSN08 Down Z-disc organization 0.000630429 2 NaN CSRP3;MYPN;PDLIM3;TCAP
ponatinib Kinase inhibitor Yes MSN09 Down Z-disc organization 0.000463359 2 NaN CSRP3;MYPN;PDLIM3;TCAP
ponatinib Kinase inhibitor Yes MSN01 Up Mitotic spindle disassembly 0.020906845 20.5 NaN CDK1
ponatinib Kinase inhibitor Yes MSN02 Up Mitotic spindle disassembly 0.020377558 15 NaN CDK1
ponatinib Kinase inhibitor Yes MSN06 Up Mitotic spindle disassembly 0.018966126 17.5 NaN CDK1
ponatinib Kinase inhibitor Yes MSN08 Up Mitotic spindle disassembly 0.0200247 21.5 NaN CDK1
ponatinib Kinase inhibitor Yes MSN09 Up Mitotic spindle disassembly 0.022230064 16 NaN CDK1
ponatinib Kinase inhibitor Yes MSN02 Down Muscarinic receptor signaling 0.008957388 8 NaN CHRM4;RGS4
ponatinib Kinase inhibitor Yes MSN01 Down Myofibril formation 0.001845347 3 6 Down by cardiotoxic TKIs DES;KLHL41;XIRP1
ponatinib Kinase inhibitor Yes MSN02 Down Myofibril formation 0.025134697 12 6 Down by cardiotoxic TKIs KLHL41;XIRP1
ponatinib Kinase inhibitor Yes MSN06 Down Myofibril formation 0.002126394 4 6 Down by cardiotoxic TKIs DES;KLHL41;XIRP1
ponatinib Kinase inhibitor Yes MSN08 Down Myofibril formation 0.026291036 11.5 6 Down by cardiotoxic TKIs KLHL41;XIRP1
ponatinib Kinase inhibitor Yes MSN09 Down Myofibril formation 0.022575326 8 6 Down by cardiotoxic TKIs KLHL41;XIRP1
ponatinib Kinase inhibitor Yes MSN05 Up Neuregulin receptor signaling 0.03798877 7 NaN ERBB4;NRG1
ponatinib Kinase inhibitor Yes MSN01 Up Osteonectin receptor signaling 0.002540098 11.5 NaN SMOC2;SPOCK1
ponatinib Kinase inhibitor Yes MSN02 Down Osteopontin receptor signaling 0.025317572 14 NaN SPP1
ponatinib Kinase inhibitor Yes MSN05 Down Osteopontin receptor signaling 0.016055046 8.5 NaN SPP1
ponatinib Kinase inhibitor Yes MSN01 Down Platelet-derived growth factor receptor signaling 0.002488588 4 14 Down by cardiotoxic TKIs FOSL1;PDGFB;PDGFRA
ponatinib Kinase inhibitor Yes MSN02 Down Platelet-derived growth factor receptor signaling 0.002278637 6 14 Down by cardiotoxic TKIs FOSL1;PDGFRA;PDGFRB
ponatinib Kinase inhibitor Yes MSN05 Down Platelet-derived growth factor receptor signaling 0.012818624 6 14 Down by cardiotoxic TKIs PDGFRA;PDGFRB
ponatinib Kinase inhibitor Yes MSN06 Down Platelet-derived growth factor receptor signaling 0.002864754 6 14 Down by cardiotoxic TKIs FOSL1;PDGFB;PDGFRA
ponatinib Kinase inhibitor Yes MSN08 Down Platelet-derived growth factor receptor signaling 0.031591061 13 14 Down by cardiotoxic TKIs FOSL1;PDGFRA
ponatinib Kinase inhibitor Yes MSN02 Down Potassium transmembrane transport 0.021936586 11 NaN ATP1A2;ATP1A3;SLC12A6
ponatinib Kinase inhibitor Yes MSN05 Down Procollagen cleavage into collagen 0.047400097 16 NaN PCOLCE
ponatinib Kinase inhibitor Yes MSN06 Down Progesterone receptor signaling 0.027434721 11 NaN PGR
ponatinib Kinase inhibitor Yes MSN06 Up Protein polyubiquitination 0.036079961 23 NaN ISG15;UCHL1
ponatinib Kinase inhibitor Yes MSN09 Up Protein polyubiquitination 0.048125749 23 NaN ISG15;UCHL1
ponatinib Kinase inhibitor Yes MSN05 Down Ribonucleotide reduction 0.047400097 16 NaN RRM2
ponatinib Kinase inhibitor Yes MSN05 Up Semaphorin signaling 0.015618719 3 NaN CRMP1;DPYSL3;NRP2;SEMA6B
ponatinib Kinase inhibitor Yes MSN01 Up Serine and glycine metabolism 5.48E-05 5 19 Up by cardiotoxic TKIs PHGDH;PSAT1;SHMT2;SLC1A5
ponatinib Kinase inhibitor Yes MSN02 Up Serine and glycine metabolism 0.001221097 6 19 Up by cardiotoxic TKIs PHGDH;PSAT1;SHMT2
ponatinib Kinase inhibitor Yes MSN06 Up Serine and glycine metabolism 3.74E-05 5 19 Up by cardiotoxic TKIs PHGDH;PSAT1;SHMT2;SLC1A5
ponatinib Kinase inhibitor Yes MSN08 Up Serine and glycine metabolism 4.63E-05 5 19 Up by cardiotoxic TKIs PHGDH;PSAT1;SHMT2;SLC1A5
ponatinib Kinase inhibitor Yes MSN09 Up Serine and glycine metabolism 0.00156935 5 19 Up by cardiotoxic TKIs PHGDH;PSAT1;SHMT2
ponatinib Kinase inhibitor Yes MSN05 Down Serine and glycine metabolism 1.94E-05 1 NaN PHGDH;PSAT1;SHMT2;SLC1A5
ponatinib Kinase inhibitor Yes MSN01 Up Serotonin inactivation 0.041378401 26 NaN MAOA
ponatinib Kinase inhibitor Yes MSN02 Up Serotonin inactivation 0.040341633 19.5 NaN MAOA
ponatinib Kinase inhibitor Yes MSN06 Up Serotonin inactivation 0.037574179 24 NaN MAOA
ponatinib Kinase inhibitor Yes MSN08 Up Serotonin inactivation 0.039650143 27.5 NaN MAOA
ponatinib Kinase inhibitor Yes MSN01 Up Sister chromatid attachment to mitotic spindle 0.041378401 26 NaN NUF2
ponatinib Kinase inhibitor Yes MSN02 Up Sister chromatid attachment to mitotic spindle 0.000413484 5 NaN NUF2;TACC3
ponatinib Kinase inhibitor Yes MSN06 Up Sister chromatid attachment to mitotic spindle 0.000358072 8 NaN NUF2;TACC3
ponatinib Kinase inhibitor Yes MSN08 Up Sister chromatid attachment to mitotic spindle 0.000399257 10 NaN NUF2;TACC3
ponatinib Kinase inhibitor Yes MSN09 Up Sister chromatid attachment to mitotic spindle 0.043967869 21 NaN NUF2
ponatinib Kinase inhibitor Yes MSN01 Up Sister chromatid segregation 0.000172258 7 NaN ESPL1;PTTG1;TOP2A
ponatinib Kinase inhibitor Yes MSN02 Up Sister chromatid segregation 0.005875567 11 NaN PTTG1;TOP2A
ponatinib Kinase inhibitor Yes MSN06 Up Sister chromatid segregation 0.005107525 13.5 NaN PTTG1;TOP2A
ponatinib Kinase inhibitor Yes MSN08 Up Sister chromatid segregation 0.00015158 9 NaN ESPL1;PTTG1;TOP2A
ponatinib Kinase inhibitor Yes MSN09 Up Sister chromatid segregation 0.006960163 11.5 NaN PTTG1;TOP2A
ponatinib Kinase inhibitor Yes MSN08 Down Sodium transmembrane transport 0.049247428 14 NaN ATP1A2;SLC5A1;SLC9A1
ponatinib Kinase inhibitor Yes MSN06 Down Thick myofilament organization 0.002210018 5 NaN MYH7;TTN
ponatinib Kinase inhibitor Yes MSN09 Down Thick myofilament organization 0.001681304 3 NaN MYH7;TTN
ponatinib Kinase inhibitor Yes MSN01 Down Thin myofilament organization 2.36E-07 1 21 Down by cardiotoxic TKIs ACTA1;LMOD3;TNNI3;TPM2;TPM4
ponatinib Kinase inhibitor Yes MSN02 Down Thin myofilament organization 1.33E-05 1 21 Down by cardiotoxic TKIs ACTA1;LMOD3;TNNI3;TPM2
ponatinib Kinase inhibitor Yes MSN06 Down Thin myofilament organization 1.82E-05 1 21 Down by cardiotoxic TKIs ACTA1;LMOD3;TNNI3;TPM2
ponatinib Kinase inhibitor Yes MSN08 Down Thin myofilament organization 1.46E-05 1 21 Down by cardiotoxic TKIs ACTA1;LMOD3;TNNI3;TPM2
ponatinib Kinase inhibitor Yes MSN09 Down Thin myofilament organization 1.06E-05 1 21 Down by cardiotoxic TKIs ACTA1;LMOD3;TNNI3;TPM2
ponatinib Kinase inhibitor Yes MSN08 Up Thrombospondin receptor signaling 0.002332606 12.5 NaN THBS1;THBS4
ponatinib Kinase inhibitor Yes MSN02 Down Tropoelastin synthesis 0.025317572 14 NaN ELN
ponatinib Kinase inhibitor Yes MSN05 Down Tropoelastin synthesis 0.016055046 8.5 NaN ELN
ponatinib Kinase inhibitor Yes MSN06 Down Tropoelastin synthesis 0.027434721 11 NaN ELN
ponatinib Kinase inhibitor Yes MSN08 Down Tropoelastin synthesis 0.025935074 9.5 NaN ELN
ponatinib Kinase inhibitor Yes MSN09 Down Tropoelastin synthesis 0.02390614 12 NaN ELN
ponatinib Kinase inhibitor Yes MSN02 Down Vascular endothelial growth factor receptor signaling 0.012331868 9 NaN FLT1;KDR
ponatinib Kinase inhibitor Yes MSN08 Down Vascular endothelial growth factor receptor signaling 0.012914996 4 NaN FLT1;KDR
ponatinib Kinase inhibitor Yes MSN09 Up Versican receptor signaling 0.043967869 21 NaN VCAN
ponatinib Kinase inhibitor Yes MSN09 Up Versican synthesis 0.022230064 16 NaN VCAN
ponatinib Kinase inhibitor Yes MSN06 Down Water transmembrane transport 0.018831061 8.5 9 Down by cardiotoxic TKIs AQP1;AQP3
ponatinib Kinase inhibitor Yes MSN08 Down Water transmembrane transport 0.01692739 6 9 Down by cardiotoxic TKIs AQP1;AQP3
ponatinib Kinase inhibitor Yes MSN05 Up WNT-Beta-catenin signaling pathway 0.000457851 1 NaN APCDD1;DKK2;DKK3;FRZB;FZD1;FZD2;FZD8;SFRP2
ponatinib Kinase inhibitor Yes MSN06 Up WNT-Beta-catenin signaling pathway 0.033030217 22 NaN FRZB;FZD10;PAX6;SFRP2
ponatinib Kinase inhibitor Yes MSN08 Up WNT-Beta-catenin signaling pathway 0.039120547 26 NaN FRZB;FZD10;PAX6;SFRP2
ponatinib Kinase inhibitor Yes MSN05 Up Acetylcholine-mediated control of postsynaptic potential 0.015642737 4.5 NaN ACHE;AGRN
ponatinib Kinase inhibitor Yes MSN01 Down Actin filament bundling and crosslinking 0.029402741 13.5 NaN FLNB;TAGLN;USH1C
ponatinib Kinase inhibitor Yes MSN09 Down Actin filament bundling and crosslinking 0.023408099 9.5 NaN FLNB;TAGLN;USH1C
ponatinib Kinase inhibitor Yes MSN01 Down Adrenergic receptor signaling 0.029402741 13.5 8 Down by cardiotoxic TKIs RASD1;RGS16;RGS4
ponatinib Kinase inhibitor Yes MSN06 Down Adrenergic receptor signaling 0.033358365 13 8 Down by cardiotoxic TKIs PDE4D;RASD1;RGS4
ponatinib Kinase inhibitor Yes MSN09 Down Adrenergic receptor signaling 0.023408099 9.5 8 Down by cardiotoxic TKIs GRK5;RGS16;RGS4
ponatinib Kinase inhibitor Yes MSN09 Down Aggrecan synthesis 0.02390614 12 NaN ACAN
ponatinib Kinase inhibitor Yes MSN01 Up Albumin mediated blood protein transport 0.020906845 20.5 NaN ALB
ponatinib Kinase inhibitor Yes MSN02 Up Albumin mediated blood protein transport 0.020377558 15 NaN ALB
ponatinib Kinase inhibitor Yes MSN05 Up Albumin mediated blood protein transport 0.028669725 6 NaN ALB
ponatinib Kinase inhibitor Yes MSN06 Up Albumin mediated blood protein transport 0.018966126 17.5 NaN ALB
ponatinib Kinase inhibitor Yes MSN08 Up Albumin mediated blood protein transport 0.0200247 21.5 NaN ALB
ponatinib Kinase inhibitor Yes MSN09 Up Albumin mediated blood protein transport 0.022230064 16 NaN ALB
ponatinib Kinase inhibitor Yes MSN09 Down Alternative complement pathway 0.00542891 4.5 NaN C3;CFH
ponatinib Kinase inhibitor Yes MSN01 Down Antigen presentation via MHC class I molecules 0.026625456 11.5 NaN B2M;HLA-A
ponatinib Kinase inhibitor Yes MSN01 Up Aspartate and arginine metabolism 0.017535602 18 NaN ARG2;SLC7A1
ponatinib Kinase inhibitor Yes MSN08 Up Aspartate and arginine metabolism 0.01616 19 NaN ARG2;SLC7A1
ponatinib Kinase inhibitor Yes MSN05 Up Axonal intermediate filament dynamics 0.015642737 4.5 NaN NEFH;NEFL
ponatinib Kinase inhibitor Yes MSN01 Down Biglycan synthesis 0.026111503 10 18 Down by cardiotoxic TKIs BGN
ponatinib Kinase inhibitor Yes MSN02 Down Biglycan synthesis 0.025317572 14 18 Down by cardiotoxic TKIs BGN
ponatinib Kinase inhibitor Yes MSN05 Down Biglycan synthesis 0.016055046 8.5 18 Down by cardiotoxic TKIs BGN
ponatinib Kinase inhibitor Yes MSN06 Down Biglycan synthesis 0.027434721 11 18 Down by cardiotoxic TKIs BGN
ponatinib Kinase inhibitor Yes MSN08 Down Biglycan synthesis 0.025935074 9.5 18 Down by cardiotoxic TKIs BGN
ponatinib Kinase inhibitor Yes MSN09 Down Biglycan synthesis 0.02390614 12 18 Down by cardiotoxic TKIs BGN
ponatinib Kinase inhibitor Yes MSN02 Up Calcitonin receptor signaling 0.040341633 19.5 NaN CALCB
ponatinib Kinase inhibitor Yes MSN01 Down Cardiomyocyte pacemaker current generation 0.017146691 8.5 NaN CACNA1G;HCN4
ponatinib Kinase inhibitor Yes MSN02 Down Cardiomyocyte pacemaker current generation 0.000818308 3 NaN CACNA1D;CACNA1G;HCN4
ponatinib Kinase inhibitor Yes MSN06 Down Cardiomyocyte pacemaker current generation 0.001033726 3 NaN CACNA1D;CACNA1G;HCN4
ponatinib Kinase inhibitor Yes MSN08 Down Cardiomyocyte pacemaker current generation 0.01692739 6 NaN CACNA1G;HCN4
ponatinib Kinase inhibitor Yes MSN05 Down Cardiomyocyte repolarization during action potential and hyperpolarization 0.02055093 12 NaN KCNIP2;KCNQ1
ponatinib Kinase inhibitor Yes MSN01 Down CCN intercellular signaling protein family receptor signaling 0.006449906 5 NaN CTGF;CYR61
ponatinib Kinase inhibitor Yes MSN09 Down CCN intercellular signaling protein family receptor signaling 0.00542891 4.5 NaN CTGF;CYR61
ponatinib Kinase inhibitor Yes MSN09 Down CD44-Mediated leukocyte rolling 0.047242835 17.5 NaN CD44
ponatinib Kinase inhibitor Yes MSN01 Up Centrosome maturation 0.001726344 9.5 NaN AURKA;PLK1;TPX2
ponatinib Kinase inhibitor Yes MSN02 Up Centrosome maturation 0.001603753 8.5 NaN AURKA;PLK1;TPX2
ponatinib Kinase inhibitor Yes MSN06 Up Centrosome maturation 5.53E-05 6.5 NaN AURKA;CDC25B;PLK1;TPX2
ponatinib Kinase inhibitor Yes MSN08 Up Centrosome maturation 6.83E-05 6.5 NaN AURKA;CDC25B;PLK1;TPX2
ponatinib Kinase inhibitor Yes MSN09 Up Centrosome maturation 0.002058279 6.5 NaN AURKA;PLK1;TPX2
ponatinib Kinase inhibitor Yes MSN06 Up Centrosome organization 0.001785173 9 NaN ASPM;ATF5;NEK2;PAX6;POC1A;TACC3
ponatinib Kinase inhibitor Yes MSN08 Up Centrosome organization 0.011553947 18 NaN ASPM;ATF5;NEK2;PAX6;TACC3
ponatinib Kinase inhibitor Yes MSN01 Up Centrosome separation 1.82E-10 1 NaN AURKA;CCNB1;CDK1;ESPL1;KIF11;NEK2;SPAG5
ponatinib Kinase inhibitor Yes MSN02 Up Centrosome separation 1.32E-08 1 NaN AURKA;CCNB1;CDK1;KIF11;NEK2;SPAG5
ponatinib Kinase inhibitor Yes MSN06 Up Centrosome separation 8.56E-09 1 NaN AURKA;CCNB1;CDK1;KIF11;NEK2;SPAG5
ponatinib Kinase inhibitor Yes MSN08 Up Centrosome separation 1.34E-10 1 NaN AURKA;CCNB1;CDK1;ESPL1;KIF11;NEK2;SPAG5
ponatinib Kinase inhibitor Yes MSN09 Up Centrosome separation 2.22E-08 2 NaN AURKA;CCNB1;CDK1;KIF11;NEK2;SPAG5
ponatinib Kinase inhibitor Yes MSN02 Down Chloride transmembrane transport 0.041452288 16 17 Down by cardiotoxic TKIs SLC12A6;SLC12A7
ponatinib Kinase inhibitor Yes MSN06 Down Chloride transmembrane transport 0.047941794 14 17 Down by cardiotoxic TKIs SLC12A6;SLC12A7
ponatinib Kinase inhibitor Yes MSN09 Down Chloride transmembrane transport 0.037334294 14 17 Down by cardiotoxic TKIs ANO1;SLC12A7
ponatinib Kinase inhibitor Yes MSN01 Up Cholesterol-sensitive control of SREBP activation 0.006176635 14.5 15 Up by cardiotoxic TKIs INSIG1;SREBF1
ponatinib Kinase inhibitor Yes MSN08 Up Cholesterol-sensitive control of SREBP activation 0.005678798 15 15 Up by cardiotoxic TKIs INSIG1;SREBF1
ponatinib Kinase inhibitor Yes MSN05 Down Cholesterol-sensitive control of SREBP activation 0.003685571 4.5 NaN INSIG1;SREBF1
ponatinib Kinase inhibitor Yes MSN02 Up Classical complement pathway 0.008115724 12 NaN C1R;C1S
ponatinib Kinase inhibitor Yes MSN01 Down Classical complement pathway 0.013083845 7 NaN C1QB;C1QC
ponatinib Kinase inhibitor Yes MSN02 Down Collagen fiber crosslinking 0.006072761 7 NaN LOX;PXDN
ponatinib Kinase inhibitor Yes MSN01 Up Collagen fibril organization by fibril-associated bridges 0.006176635 14.5 NaN COL9A2;COL9A3
ponatinib Kinase inhibitor Yes MSN06 Up Collagen fibril organization by fibril-associated bridges 0.005107525 13.5 NaN COL9A2;COL9A3
ponatinib Kinase inhibitor Yes MSN09 Up Collagen fibril organization by fibril-associated bridges 0.006960163 11.5 NaN COL9A2;COL9A3
ponatinib Kinase inhibitor Yes MSN01 Down Collagen fibril organization by fibril-associated bridges 0.009508626 6 NaN COL12A1;COL14A1
ponatinib Kinase inhibitor Yes MSN05 Down Collagen fibril organization by fibril-associated bridges 0.003685571 4.5 NaN COL9A2;COL9A3
ponatinib Kinase inhibitor Yes MSN08 Down Collagen fibril organization by fibril-associated bridges 0.009384811 3 NaN COL12A1;COL14A1
ponatinib Kinase inhibitor Yes MSN01 Up Contractile ring constriction 0.004175176 13 NaN ANLN;ECT2
ponatinib Kinase inhibitor Yes MSN06 Up Contractile ring constriction 0.003448018 11.5 NaN ANLN;ECT2
ponatinib Kinase inhibitor Yes MSN08 Up Contractile ring constriction 0.003836392 14 NaN ANLN;ECT2
ponatinib Kinase inhibitor Yes MSN09 Up Contractile ring constriction 0.004708979 9.5 NaN ANLN;ECT2
ponatinib Kinase inhibitor Yes MSN01 Up Decorin synthesis 0.020906845 20.5 NaN DCN
ponatinib Kinase inhibitor Yes MSN02 Up Decorin synthesis 0.020377558 15 NaN DCN
ponatinib Kinase inhibitor Yes MSN06 Up Decorin synthesis 0.018966126 17.5 NaN DCN
ponatinib Kinase inhibitor Yes MSN08 Up Decorin synthesis 0.0200247 21.5 NaN DCN
ponatinib Kinase inhibitor Yes MSN09 Up Decorin synthesis 0.022230064 16 NaN DCN
ponatinib Kinase inhibitor Yes MSN05 Down Decorin synthesis 0.016055046 8.5 NaN DCN
ponatinib Kinase inhibitor Yes MSN01 Up Epithelial intermediate filament dynamics 0.011215577 17 NaN KRT7;TCHH
ponatinib Kinase inhibitor Yes MSN06 Up Epithelial intermediate filament dynamics 0.009298267 15 NaN KRT7;TCHH
ponatinib Kinase inhibitor Yes MSN08 Up Epithelial intermediate filament dynamics 0.010323714 17 NaN KRT7;TCHH
ponatinib Kinase inhibitor Yes MSN01 Up Equatorial RhoA activation 0.002540098 11.5 NaN ECT2;KIF23
ponatinib Kinase inhibitor Yes MSN06 Up Equatorial RhoA activation 0.002094978 10 NaN ECT2;KIF23
ponatinib Kinase inhibitor Yes MSN08 Up Equatorial RhoA activation 0.002332606 12.5 NaN ECT2;KIF23
ponatinib Kinase inhibitor Yes MSN09 Up Equatorial RhoA activation 0.002867401 8 NaN ECT2;KIF23
ponatinib Kinase inhibitor Yes MSN01 Up Eukaryotic kinetochore dynamics 6.30E-08 2 NaN BUB1;CENPE;CENPF;KNSTRN;MAD2L1;NDC80;NUF2;TTK;ZWINT
ponatinib Kinase inhibitor Yes MSN02 Up Eukaryotic kinetochore dynamics 9.81E-06 4 NaN BUB1;CENPE;CENPF;KNSTRN;NDC80;NUF2;TTK
ponatinib Kinase inhibitor Yes MSN06 Up Eukaryotic kinetochore dynamics 4.41E-07 4 NaN BUB1;CENPE;CENPF;KNSTRN;MAD2L1;NDC80;NUF2;TTK
ponatinib Kinase inhibitor Yes MSN08 Up Eukaryotic kinetochore dynamics 6.66E-07 4 NaN BUB1;CENPE;CENPF;KNSTRN;MAD2L1;NDC80;NUF2;TTK
ponatinib Kinase inhibitor Yes MSN09 Up Eukaryotic kinetochore dynamics 6.74E-09 1 NaN BUB1;CENPE;CENPF;KNSTRN;MAD2L1;NDC80;NUF2;SPDL1;TTK;ZWINT
ponatinib Kinase inhibitor Yes MSN06 Down Extracellular matrix breakdown and membrane shedding by adamalysins 0.003825399 7 NaN ADAM12;ADAMTS1;ADAMTS5;ADAMTS7
ponatinib Kinase inhibitor Yes MSN09 Up Extracellular matrix breakdown by cathepsins 0.019690847 13 NaN CTSF;CTSV
ponatinib Kinase inhibitor Yes MSN05 Down Extracellular matrix breakdown by heparanases and sulfatases 0.001505846 3 NaN SULF1;SULF2
ponatinib Kinase inhibitor Yes MSN02 Down Extracellular matrix breakdown by matrix metalloproteases 0.001204532 4 NaN MMP14;MMP2;MMP3
ponatinib Kinase inhibitor Yes MSN08 Down Extracellular matrix breakdown by matrix metalloproteases 0.021394782 8 NaN MMP14;MMP2
ponatinib Kinase inhibitor Yes MSN05 Up Fibrillar collagen core structure organization 0.002411805 2 NaN COL2A1;COL5A1;COL5A2
ponatinib Kinase inhibitor Yes MSN01 Down Fibrillar collagen core structure organization 0.026625456 11.5 NaN COL1A1;COL1A2
ponatinib Kinase inhibitor Yes MSN02 Down Fibrillar collagen core structure organization 0.001688656 5 NaN COL11A2;COL1A1;COL1A2
ponatinib Kinase inhibitor Yes MSN05 Down Fibrillar collagen core structure organization 0.000449564 2 NaN COL11A2;COL1A2;COL3A1
ponatinib Kinase inhibitor Yes MSN08 Down Fibrillar collagen core structure organization 0.026291036 11.5 NaN COL1A1;COL1A2
ponatinib Kinase inhibitor Yes MSN01 Up G2 M transition checkpoint 0.001726344 9.5 NaN CCNB1;CDC25C;CDK1
ponatinib Kinase inhibitor Yes MSN02 Up G2 M transition checkpoint 0.001603753 8.5 NaN CCNB1;CDC25C;CDK1
ponatinib Kinase inhibitor Yes MSN06 Up G2 M transition checkpoint 5.53E-05 6.5 NaN CCNB1;CDC25B;CDC25C;CDK1
ponatinib Kinase inhibitor Yes MSN08 Up G2 M transition checkpoint 6.83E-05 6.5 NaN CCNB1;CDC25B;CDC25C;CDK1
ponatinib Kinase inhibitor Yes MSN09 Up G2 M transition checkpoint 0.002058279 6.5 NaN CCNB1;CDC25C;CDK1
ponatinib Kinase inhibitor Yes MSN02 Down Gap junction organization 0.047569054 17 24 Down by cardiotoxic TKIs GJA5;GJB2
ponatinib Kinase inhibitor Yes MSN08 Down Gap junction organization 0.049677703 15 24 Down by cardiotoxic TKIs GJA5;GJB2
ponatinib Kinase inhibitor Yes MSN09 Down Gap junction organization 0.042882493 15.5 24 Down by cardiotoxic TKIs GJA5;GJB2
ponatinib Kinase inhibitor Yes MSN01 Up Glutamate and glutamine metabolism 0.029170805 24 NaN SLC1A5;SLC7A5
ponatinib Kinase inhibitor Yes MSN06 Up Glutamate and glutamine metabolism 0.024338824 21 NaN SLC1A5;SLC7A5
ponatinib Kinase inhibitor Yes MSN08 Up Glutamate and glutamine metabolism 0.026929091 25 NaN SLC1A5;SLC7A5
ponatinib Kinase inhibitor Yes MSN05 Down Glutamate and glutamine metabolism 0.017800882 11 NaN GLUL;SLC1A5
ponatinib Kinase inhibitor Yes MSN05 Down Glycogen synthesis and glycogenolysis 0.026538471 13 NaN PPP1R3A;PYGM
ponatinib Kinase inhibitor Yes MSN09 Down G-protein coupled receptor signaling pathway 0.011398387 6 NaN GRK5;RGS16;RGS4
ponatinib Kinase inhibitor Yes MSN02 Up Growth differentiation factor receptor signaling 0.010676413 13 NaN GDF15;GDF2
ponatinib Kinase inhibitor Yes MSN01 Down Growth differentiation factor receptor signaling 0.017146691 8.5 NaN GDF11;GDF6
ponatinib Kinase inhibitor Yes MSN02 Down Growth differentiation factor receptor signaling 0.016169721 10 NaN GDF11;GDF6
ponatinib Kinase inhibitor Yes MSN06 Down Growth differentiation factor receptor signaling 0.018831061 8.5 NaN GDF11;GDF6
ponatinib Kinase inhibitor Yes MSN08 Down Growth differentiation factor receptor signaling 0.01692739 6 NaN GDF11;GDF6
ponatinib Kinase inhibitor Yes MSN09 Down Growth differentiation factor receptor signaling 0.014496215 7 NaN GDF11;GDF6
ponatinib Kinase inhibitor Yes MSN05 Down Hemoglobin and myoglobin synthesis 0.047400097 16 NaN MB
ponatinib Kinase inhibitor Yes MSN09 Down Hepatocyte growth factor receptor signaling 0.047242835 17.5 NaN HGF
ponatinib Kinase inhibitor Yes MSN01 Up Hyaluronan-mediated motility receptor signaling 0.020906845 20.5 NaN HMMR
ponatinib Kinase inhibitor Yes MSN06 Up Hyaluronan-mediated motility receptor signaling 0.018966126 17.5 NaN HMMR
ponatinib Kinase inhibitor Yes MSN08 Up Hyaluronan-mediated motility receptor signaling 0.0200247 21.5 NaN HMMR
ponatinib Kinase inhibitor Yes MSN09 Up Hyaluronan-mediated motility receptor signaling 0.022230064 16 NaN HMMR
ponatinib Kinase inhibitor Yes MSN01 Up Inhibition of apoptosis 0.025022959 23 NaN BIRC5;IFI6
ponatinib Kinase inhibitor Yes MSN02 Up Inhibition of apoptosis 0.023853258 17 NaN BIRC5;IFI6
ponatinib Kinase inhibitor Yes MSN05 Up Inhibition of apoptosis 0.044739094 8 NaN IFI6;XAF1
ponatinib Kinase inhibitor Yes MSN06 Up Inhibition of apoptosis 0.02085161 20 NaN BIRC5;IFI6
ponatinib Kinase inhibitor Yes MSN08 Up Inhibition of apoptosis 0.023086706 24 NaN BIRC5;IFI6
ponatinib Kinase inhibitor Yes MSN09 Up Inhibition of apoptosis 0.02804976 19 NaN BIRC5;IFI6
ponatinib Kinase inhibitor Yes MSN01 Up Intracellular bridge assembly 0.00128782 8 NaN INCENP;KIF23
ponatinib Kinase inhibitor Yes MSN02 Up Intracellular bridge assembly 0.001223743 7 NaN INCENP;KIF23
ponatinib Kinase inhibitor Yes MSN08 Up Intracellular bridge assembly 0.00118192 11 NaN INCENP;KIF23
ponatinib Kinase inhibitor Yes MSN02 Up JAK-STAT signaling pathway 0.032023829 18 NaN STAT1;USP18
ponatinib Kinase inhibitor Yes MSN09 Down JAK-STAT signaling pathway 0.042882493 15.5 NaN SOCS2;STAT4
ponatinib Kinase inhibitor Yes MSN05 Down Lipogenesis 0.031853721 14 NaN FASN
ponatinib Kinase inhibitor Yes MSN01 Up Metaphase to anaphase checkpoint 3.68E-07 3 NaN BUB1;BUB1B;CCNB2;CDC20;CENPE;MAD2L1;PTTG1;TTK
ponatinib Kinase inhibitor Yes MSN02 Up Metaphase to anaphase checkpoint 4.48E-06 3 NaN BUB1;BUB1B;CCNB2;CDC20;CENPE;PTTG1;TTK
ponatinib Kinase inhibitor Yes MSN06 Up Metaphase to anaphase checkpoint 1.75E-07 3 NaN BUB1;BUB1B;CCNB2;CDC20;CENPE;MAD2L1;PTTG1;TTK
ponatinib Kinase inhibitor Yes MSN08 Up Metaphase to anaphase checkpoint 2.65E-07 3 NaN BUB1;BUB1B;CCNB2;CDC20;CENPE;MAD2L1;PTTG1;TTK
ponatinib Kinase inhibitor Yes MSN09 Up Metaphase to anaphase checkpoint 5.88E-07 3 NaN BUB1;BUB1B;CCNB2;CDC20;CENPE;MAD2L1;PTTG1;TTK
ponatinib Kinase inhibitor Yes MSN01 Up Methionine cycle 0.041378401 26 NaN BHMT
ponatinib Kinase inhibitor Yes MSN08 Up Methionine cycle 0.039650143 27.5 NaN BHMT
ponatinib Kinase inhibitor Yes MSN09 Up Methionine cycle 0.043967869 21 NaN BHMT
ponatinib Kinase inhibitor Yes MSN02 Down Microfibril scaffold organization 0.049996342 18 NaN FBN1
ponatinib Kinase inhibitor Yes MSN01 Up Mitotic chromosome condensation 0.00852857 16 NaN INCENP;SMC4
ponatinib Kinase inhibitor Yes MSN08 Up Mitotic chromosome condensation 0.007845779 16 NaN INCENP;SMC4
ponatinib Kinase inhibitor Yes MSN01 Up Mitotic H3 phosphorylation and dephosphorylation 8.75E-05 6 NaN AURKB;CCNA2;INCENP
ponatinib Kinase inhibitor Yes MSN02 Up Mitotic H3 phosphorylation and dephosphorylation 0.003970259 10 NaN CCNA2;INCENP
ponatinib Kinase inhibitor Yes MSN06 Up Mitotic H3 phosphorylation and dephosphorylation 0.003448018 11.5 NaN AURKB;CCNA2
ponatinib Kinase inhibitor Yes MSN08 Up Mitotic H3 phosphorylation and dephosphorylation 7.69E-05 8 NaN AURKB;CCNA2;INCENP
ponatinib Kinase inhibitor Yes MSN09 Up Mitotic H3 phosphorylation and dephosphorylation 0.004708979 9.5 NaN AURKB;CCNA2
ponatinib Kinase inhibitor Yes MSN01 Up Mitotic spindle assembly 4.30E-06 4 NaN CKAP2;DLGAP5;NUSAP1;TPX2;TTK
ponatinib Kinase inhibitor Yes MSN02 Up Mitotic spindle assembly 1.02E-07 2 NaN CKAP2;DLGAP5;NUSAP1;TACC3;TPX2;TTK
ponatinib Kinase inhibitor Yes MSN06 Up Mitotic spindle assembly 6.67E-08 2 NaN CKAP2;DLGAP5;NUSAP1;TACC3;TPX2;TTK
ponatinib Kinase inhibitor Yes MSN08 Up Mitotic spindle assembly 9.21E-08 2 NaN CKAP2;DLGAP5;NUSAP1;TACC3;TPX2;TTK
ponatinib Kinase inhibitor Yes MSN09 Up Mitotic spindle assembly 5.80E-06 4 NaN CKAP2;DLGAP5;NUSAP1;TPX2;TTK
pioglitazone Antidiabetic No MSN05 Down ER unfolded protein response pathway 0.00042817 3 NaN ATF4;DDIT3;HERPUD1
pioglitazone Antidiabetic No MSN01 Up Extracellular matrix breakdown and membrane shedding by adamalysins 0.013966639 7 NaN ADAM33;ADAMTS14;ADAMTS2
pioglitazone Antidiabetic No MSN09 Up Extracellular matrix breakdown and membrane shedding by adamalysins 0.001117947 2 NaN ADAM12;ADAM33;ADAMTS14;ADAMTS2
pioglitazone Antidiabetic No MSN05 Down Extracellular matrix breakdown and membrane shedding by adamalysins 6.48E-06 1 NaN ADAM12;ADAM19;ADAMTS1;ADAMTS14;ADAMTS5;ADAMTS8
pioglitazone Antidiabetic No MSN05 Up Extracellular matrix breakdown by cathepsins 0.022575326 8.5 NaN CTSD;CTSV
pioglitazone Antidiabetic No MSN08 Up Extracellular matrix breakdown by cathepsins 0.01824187 7 NaN CTSF;CTSV
pioglitazone Antidiabetic No MSN01 Up Extracellular matrix breakdown by matrix metalloproteases 0.014799877 8 NaN MMP1;MMP2
pioglitazone Antidiabetic No MSN02 Up Extracellular matrix breakdown by matrix metalloproteases 0.014452362 9 NaN MMP1;MMP2
pioglitazone Antidiabetic No MSN08 Up Extracellular matrix breakdown by matrix metalloproteases 0.014799877 6 NaN MMP1;MMP2
pioglitazone Antidiabetic No MSN09 Up Extracellular matrix breakdown by matrix metalloproteases 0.012553331 10 NaN MMP1;MMP2
pioglitazone Antidiabetic No MSN05 Up Fibrillar collagen core structure organization 0.022575326 8.5 NaN COL5A1;COL5A2
pioglitazone Antidiabetic No MSN08 Up Fibrillar collagen core structure organization 0.001031906 1 NaN COL1A1;COL5A1;COL5A3
pioglitazone Antidiabetic No MSN09 Up Fibrillar collagen core structure organization 0.015490863 11.5 NaN COL1A1;COL5A1
pioglitazone Antidiabetic No MSN01 Down Fibrillar collagen core structure organization 1.66E-06 1 NaN COL11A1;COL1A2;COL2A1;COL3A1;COL5A2
pioglitazone Antidiabetic No MSN02 Down Fibrillar collagen core structure organization 1.69E-06 1 NaN COL11A1;COL1A2;COL2A1;COL3A1;COL5A2
pioglitazone Antidiabetic No MSN05 Down Fibrillar collagen core structure organization 0.00089029 4 NaN COL11A1;COL1A2;COL3A1
pioglitazone Antidiabetic No MSN08 Down Fibrillar collagen core structure organization 4.30E-05 1 NaN COL11A1;COL1A2;COL2A1;COL3A1
pioglitazone Antidiabetic No MSN09 Down Fibrillar collagen core structure organization 2.06E-06 1 NaN COL11A1;COL1A2;COL2A1;COL3A1;COL5A2
pioglitazone Antidiabetic No MSN09 Up Fibulin receptor signaling 0.03878543 18 NaN FBLN1
pioglitazone Antidiabetic No MSN05 Down Fibulin receptor signaling 0.040168784 12 NaN FBLN1
pioglitazone Antidiabetic No MSN08 Down GABA metabolism 0.006799947 7 NaN ABAT;SLC6A1
pioglitazone Antidiabetic No MSN05 Up Gap junction organization 0.042882493 17 NaN GJA5;GJD2
pioglitazone Antidiabetic No MSN08 Up Gap junction organization 0.002938365 4 NaN GJA5;GJC2;GJD2
pioglitazone Antidiabetic No MSN05 Up Glutamate and glutamine metabolism 0.003235004 3.5 NaN GLUL;SLC1A5;SLC7A5
pioglitazone Antidiabetic No MSN01 Down Glutamate and glutamine metabolism 0.003167864 4 NaN SLC1A5;SLC38A2;SLC7A5
pioglitazone Antidiabetic No MSN02 Down Glutamate and glutamine metabolism 0.003201324 4 NaN SLC1A5;SLC38A2;SLC7A5
pioglitazone Antidiabetic No MSN09 Down Glutamate and glutamine metabolism 0.003583963 7 NaN SLC1A5;SLC38A2;SLC7A5
pioglitazone Antidiabetic No MSN05 Down Glycogen synthesis and glycogenolysis 0.040799919 14 NaN PPP1R3A;PYGM
pioglitazone Antidiabetic No MSN09 Up Glycolysis and Gluconeogenesis 0.009827557 9 NaN PCK2;PGK1;TPI1
pioglitazone Antidiabetic No MSN02 Down Granulocyte macrophage colony-stimulating factor receptor signaling 0.047070608 21 NaN JUND
pioglitazone Antidiabetic No MSN08 Down Granulocyte macrophage colony-stimulating factor receptor signaling 0.043450255 16.5 NaN JUND
pioglitazone Antidiabetic No MSN01 Down Hepatocyte growth factor receptor signaling 0.046898366 19.5 NaN HGF
pioglitazone Antidiabetic No MSN02 Down Hepatocyte growth factor receptor signaling 0.047070608 21 NaN HGF
pioglitazone Antidiabetic No MSN09 Down Hepatocyte growth factor receptor signaling 0.048964244 23.5 NaN HGF
pioglitazone Antidiabetic No MSN05 Down HIF-1 receptor signaling pathway 0.013432039 7 NaN CITED2;EGLN3
pioglitazone Antidiabetic No MSN05 Up Inhibin receptor signaling 0.000692213 1 NaN INHBB;INHBE;TGFBR3
pioglitazone Antidiabetic No MSN01 Up Inhibition of amyloid aggregation, amyloid degradation and uptake 0.001342449 2 NaN A2M;PLAT
pioglitazone Antidiabetic No MSN02 Up Inhibition of amyloid aggregation, amyloid degradation and uptake 0.001309537 2 NaN A2M;PLAT
pioglitazone Antidiabetic No MSN08 Up Inhibition of amyloid aggregation, amyloid degradation and uptake 0.001342449 2 NaN A2M;PLAT
pioglitazone Antidiabetic No MSN09 Up Inhibition of amyloid aggregation, amyloid degradation and uptake 0.001130651 3 NaN A2M;PLAT
pioglitazone Antidiabetic No MSN05 Down Inhibition of apoptosis 0.023660622 9 NaN BIRC3;IFI6
pioglitazone Antidiabetic No MSN01 Down Insulin receptor signaling 0.048070612 22 NaN IRS1;IRS2
pioglitazone Antidiabetic No MSN09 Down Intrinsic apoptosis pathway 0.04578962 21 NaN BBC3;BCL2L1
pioglitazone Antidiabetic No MSN05 Up JAK-STAT signaling pathway 0.042882493 17 NaN SOCS2;SOCS3
pioglitazone Antidiabetic No MSN05 Down Lipogenesis 0.040168784 12 NaN FASN
pioglitazone Antidiabetic No MSN02 Down Macrophage migration inhibitory factor signaling 0.005389806 5.5 NaN ACKR3;JUND
pioglitazone Antidiabetic No MSN08 Down Macrophage migration inhibitory factor signaling 0.004599768 5 NaN ACKR3;JUND
pioglitazone Antidiabetic No MSN09 Down MAPK signaling pathway 0.037367454 18 NaN DUSP1;MAP2K6;RPS6KA2
pioglitazone Antidiabetic No MSN08 Up Methionine cycle 0.042241946 13.5 NaN BHMT
pioglitazone Antidiabetic No MSN01 Up Microfibril scaffold organization 0.042241946 15.5 NaN FBN1
pioglitazone Antidiabetic No MSN02 Up Microfibril scaffold organization 0.041723865 15.5 NaN FBN1
pioglitazone Antidiabetic No MSN09 Up Microfibril scaffold organization 0.03878543 18 NaN FBN1
pioglitazone Antidiabetic No MSN05 Down Microfibril scaffold organization 0.040168784 12 NaN FBN1
pioglitazone Antidiabetic No MSN01 Down Microtubule crosslinking and bundling 0.007900936 6.5 NaN MAP2;MTCL1
pioglitazone Antidiabetic No MSN02 Down Microtubule crosslinking and bundling 0.007958007 7.5 NaN MAP2;MTCL1
pioglitazone Antidiabetic No MSN09 Down Microtubule crosslinking and bundling 0.000285148 4 NaN DCX;MAP2;MTCL1
pioglitazone Antidiabetic No MSN05 Up Mitochondrial fission 0.032088249 15 NaN DNM1;MTFP1
pioglitazone Antidiabetic No MSN08 Up Mitotic spindle assembly 0.03031943 11 NaN DLGAP5;NUSAP1
pioglitazone Antidiabetic No MSN01 Up Myofibril formation 0.01824187 9 NaN DES;KLHL41
pioglitazone Antidiabetic No MSN02 Up Myofibril formation 0.017816642 10 NaN DES;KLHL41
pioglitazone Antidiabetic No MSN05 Up Myofibril formation 0.022575326 8.5 NaN DES;KLHL41
pioglitazone Antidiabetic No MSN09 Up Myofibril formation 0.015490863 11.5 NaN DES;KLHL41
pioglitazone Antidiabetic No MSN05 Down Natriuretic peptide receptor signaling 0.005826078 5 NaN NPPB;NPR3
pioglitazone Antidiabetic No MSN08 Down Natriuretic peptide receptor signaling 0.006799947 7 NaN NPPB;NPR3
pioglitazone Antidiabetic No MSN01 Up Neuregulin receptor signaling 0.021985266 13.5 NaN ERBB3;SH3TC2
pioglitazone Antidiabetic No MSN01 Down Osteonectin receptor signaling 5.19E-05 2 NaN SMOC2;SPARC;SPOCK1
pioglitazone Antidiabetic No MSN02 Down Osteonectin receptor signaling 5.25E-05 3 NaN SMOC2;SPARC;SPOCK1
pioglitazone Antidiabetic No MSN05 Down Osteonectin receptor signaling 3.25E-05 2 NaN SMOC2;SPARC;SPOCK1
pioglitazone Antidiabetic No MSN08 Down Osteonectin receptor signaling 0.002800402 4 NaN SMOC2;SPOCK1
pioglitazone Antidiabetic No MSN09 Down Osteonectin receptor signaling 5.92E-05 3 NaN SMOC2;SPARC;SPOCK1
pioglitazone Antidiabetic No MSN01 Up Osteopontin receptor signaling 0.021347918 11 NaN SPP1
pioglitazone Antidiabetic No MSN02 Up Osteopontin receptor signaling 0.021083275 12 NaN SPP1
pioglitazone Antidiabetic No MSN08 Up Osteopontin receptor signaling 0.021347918 9 NaN SPP1
pioglitazone Antidiabetic No MSN09 Up Osteopontin receptor signaling 0.019583627 14 NaN SPP1
pioglitazone Antidiabetic No MSN01 Down Perlecan synthesis 0.023729711 11.5 NaN HSPG2
pioglitazone Antidiabetic No MSN02 Down Perlecan synthesis 0.023817925 12.5 NaN HSPG2
pioglitazone Antidiabetic No MSN09 Down Perlecan synthesis 0.024788285 14.5 NaN HSPG2
pioglitazone Antidiabetic No MSN01 Up Platelet-derived growth factor receptor signaling 0.021985266 13.5 NaN PDGFRA;PDGFRB
pioglitazone Antidiabetic No MSN02 Up Platelet-derived growth factor receptor signaling 0.02147651 14 NaN PDGFRA;PDGFRB
pioglitazone Antidiabetic No MSN09 Down Procollagen cleavage into collagen 0.001806833 5 NaN FURIN;PCOLCE
pioglitazone Antidiabetic No MSN05 Up Progesterone receptor signaling 0.02390614 12.5 NaN PGR
pioglitazone Antidiabetic No MSN01 Down Progesterone receptor signaling 0.023729711 11.5 NaN PGR
pioglitazone Antidiabetic No MSN02 Down Progesterone receptor signaling 0.023817925 12.5 NaN PGR
pioglitazone Antidiabetic No MSN08 Down Progesterone receptor signaling 0.02196542 11 NaN PGR
pioglitazone Antidiabetic No MSN09 Down Progesterone receptor signaling 0.024788285 14.5 NaN PGR
pioglitazone Antidiabetic No MSN05 Up Prostacycline receptor signaling 0.047242835 21.5 NaN PTGIR
pioglitazone Antidiabetic No MSN01 Up Prostaglandin E2 receptor signaling 0.006432927 5.5 NaN PTGER3;RAPGEF4
pioglitazone Antidiabetic No MSN02 Up Prostaglandin E2 receptor signaling 0.006278564 5.5 NaN PTGER3;RAPGEF4
pioglitazone Antidiabetic No MSN09 Up Prostaglandin E2 receptor signaling 0.00543729 6.5 NaN PTGER3;RAPGEF4
pioglitazone Antidiabetic No MSN05 Up Removal of caspase inhibition 0.047242835 21.5 NaN XAF1
pioglitazone Antidiabetic No MSN01 Down Removal of caspase inhibition 0.046898366 19.5 NaN XAF1
pioglitazone Antidiabetic No MSN02 Down Removal of caspase inhibition 0.047070608 21 NaN XAF1
pioglitazone Antidiabetic No MSN09 Down Removal of caspase inhibition 0.048964244 23.5 NaN XAF1
pioglitazone Antidiabetic No MSN05 Up Restriction point 0.022575326 8.5 NaN CCND2;CDKN1A
pioglitazone Antidiabetic No MSN01 Down Retinoic acid receptor signaling 0.036831666 16.5 NaN NCOR2;NR4A1
pioglitazone Antidiabetic No MSN02 Down Retinoic acid receptor signaling 0.037082638 17.5 NaN NCOR2;NR4A1
pioglitazone Antidiabetic No MSN09 Down Retinoic acid receptor signaling 0.039888032 19.5 NaN NCOR2;NR4A1
pioglitazone Antidiabetic No MSN01 Up Retinol metabolism 0.000124474 1 NaN ALDH1A1;RBP1;RPE65;STRA6
pioglitazone Antidiabetic No MSN02 Up Retinol metabolism 0.000118607 1 NaN ALDH1A1;RBP1;RPE65;STRA6
pioglitazone Antidiabetic No MSN05 Up Retinol metabolism 0.003235004 3.5 NaN ALDH1A1;ALDH1A3;RLBP1
pioglitazone Antidiabetic No MSN08 Up Retinol metabolism 0.002345434 3 NaN ALDH1A1;ALDH1A3;RBP1
pioglitazone Antidiabetic No MSN09 Up Retinol metabolism 8.91E-05 1 NaN ALDH1A1;RBP1;RPE65;STRA6
pioglitazone Antidiabetic No MSN05 Down Retinol metabolism 0.027593758 10 NaN ALDH1A2;RPE65
pioglitazone Antidiabetic No MSN05 Up Semaphorin signaling 0.046903595 19 NaN DPYSL2;NRP2;PLXNB3
pioglitazone Antidiabetic No MSN05 Up Serine and glycine metabolism 0.00193367 2 NaN GLDC;PHGDH;SLC1A5
pioglitazone Antidiabetic No MSN01 Down Serine and glycine metabolism 0.02679052 15 NaN SHMT2;SLC1A5
pioglitazone Antidiabetic No MSN02 Down Serine and glycine metabolism 0.026976171 16 NaN SHMT2;SLC1A5
pioglitazone Antidiabetic No MSN08 Down Serine and glycine metabolism 0.023192176 14.5 NaN PHGDH;SHMT2
pioglitazone Antidiabetic No MSN09 Down Serine and glycine metabolism 0.002145083 6 NaN PHGDH;SHMT2;SLC1A5
pioglitazone Antidiabetic No MSN05 Up Serotonin inactivation 0.047242835 21.5 NaN MAOA
pioglitazone Antidiabetic No MSN08 Up Serotonin inactivation 0.042241946 13.5 NaN MAOA
pioglitazone Antidiabetic No MSN01 Down Serotonin inactivation 0.046898366 19.5 NaN MAOA
pioglitazone Antidiabetic No MSN02 Down Serotonin inactivation 0.047070608 21 NaN MAOA
pioglitazone Antidiabetic No MSN09 Down Serotonin inactivation 0.048964244 23.5 NaN MAOA
pioglitazone Antidiabetic No MSN01 Up Sulfonation 0.004349703 4 NaN SULT1A1;SULT1E1
pioglitazone Antidiabetic No MSN02 Up Sulfonation 0.004244577 4 NaN SULT1A1;SULT1E1
pioglitazone Antidiabetic No MSN09 Up Sulfonation 0.003672154 5 NaN SULT1A1;SULT1E1
pioglitazone Antidiabetic No MSN02 Up Thin myofilament organization 0.008668292 7.5 NaN ACTA1;TNNI3
pioglitazone Antidiabetic No MSN05 Up Thin myofilament organization 0.011045214 6 NaN ACTA1;TNNI3
pioglitazone Antidiabetic No MSN01 Up Thrombospondin receptor signaling 0.002647061 3 NaN THBS1;THBS2
pioglitazone Antidiabetic No MSN02 Up Thrombospondin receptor signaling 0.002582626 3 NaN THBS1;THBS2
pioglitazone Antidiabetic No MSN09 Up Thrombospondin receptor signaling 0.002232086 4 NaN THBS1;THBS2
pioglitazone Antidiabetic No MSN05 Up Tropoelastin synthesis 0.02390614 12.5 NaN ELN
pioglitazone Antidiabetic No MSN01 Down Tropoelastin synthesis 0.023729711 11.5 NaN ELN
pioglitazone Antidiabetic No MSN02 Down Tropoelastin synthesis 0.023817925 12.5 NaN ELN
pioglitazone Antidiabetic No MSN08 Down Tropoelastin synthesis 0.02196542 11 NaN ELN
pioglitazone Antidiabetic No MSN09 Down Tropoelastin synthesis 0.024788285 14.5 NaN ELN
pioglitazone Antidiabetic No MSN01 Up Vasoactive intestinal peptide receptor signaling 0.042241946 15.5 NaN VIPR1
pioglitazone Antidiabetic No MSN02 Up Vasoactive intestinal peptide receptor signaling 0.041723865 15.5 NaN VIPR1
pioglitazone Antidiabetic No MSN08 Up Vasoactive intestinal peptide receptor signaling 0.042241946 13.5 NaN VIPR1
pioglitazone Antidiabetic No MSN09 Up Vasoactive intestinal peptide receptor signaling 0.03878543 18 NaN VIPR1
pioglitazone Antidiabetic No MSN05 Up Versican receptor signaling 0.047242835 21.5 NaN VCAN
pioglitazone Antidiabetic No MSN01 Down Versican receptor signaling 0.046898366 19.5 NaN VCAN
pioglitazone Antidiabetic No MSN02 Down Versican receptor signaling 0.047070608 21 NaN VCAN
pioglitazone Antidiabetic No MSN08 Down Versican receptor signaling 0.043450255 16.5 NaN VCAN
pioglitazone Antidiabetic No MSN09 Down Versican receptor signaling 0.048964244 23.5 NaN VCAN
pioglitazone Antidiabetic No MSN05 Up Versican synthesis 0.02390614 12.5 NaN VCAN
pioglitazone Antidiabetic No MSN01 Down Versican synthesis 0.023729711 11.5 NaN VCAN
pioglitazone Antidiabetic No MSN02 Down Versican synthesis 0.023817925 12.5 NaN VCAN
pioglitazone Antidiabetic No MSN08 Down Versican synthesis 0.02196542 11 NaN VCAN
pioglitazone Antidiabetic No MSN09 Down Versican synthesis 0.024788285 14.5 NaN VCAN
pioglitazone Antidiabetic No MSN05 Up Vitamin D metabolism 0.003309507 5 NaN CYP24A1;CYP27A1
pioglitazone Antidiabetic No MSN01 Up Z-disc organization 0.044738024 17 NaN DES;TCAP
pioglitazone Antidiabetic No MSN02 Up Z-disc organization 0.043740316 17 NaN DES;TCAP
pioglitazone Antidiabetic No MSN08 Up Z-disc organization 0.044738024 16 NaN DES;TCAP
pioglitazone Antidiabetic No MSN09 Up Z-disc organization 0.038254008 16 NaN DES;TCAP
pioglitazone Antidiabetic No MSN05 Down Adherens junction organization 0.009287954 6 NaN ARVCF;CDH1;CDH3;RND3
pioglitazone Antidiabetic No MSN01 Down Aggrecan synthesis 0.023729711 11.5 NaN ACAN
pioglitazone Antidiabetic No MSN02 Down Aggrecan synthesis 0.023817925 12.5 NaN ACAN
pioglitazone Antidiabetic No MSN08 Down Aggrecan synthesis 0.02196542 11 NaN ACAN
pioglitazone Antidiabetic No MSN09 Down Aggrecan synthesis 0.024788285 14.5 NaN ACAN
pioglitazone Antidiabetic No MSN01 Up Albumin mediated blood protein transport 0.021347918 11 NaN ALB
pioglitazone Antidiabetic No MSN02 Up Albumin mediated blood protein transport 0.021083275 12 NaN ALB
pioglitazone Antidiabetic No MSN08 Up Albumin mediated blood protein transport 0.021347918 9 NaN ALB
pioglitazone Antidiabetic No MSN09 Up Albumin mediated blood protein transport 0.019583627 14 NaN ALB
pioglitazone Antidiabetic No MSN08 Down Amyloid plaque organization 0.023192176 14.5 NaN APBB2;HSPB6
pioglitazone Antidiabetic No MSN02 Up Axonal intermediate filament dynamics 0.008668292 7.5 NaN NEFH;NES
pioglitazone Antidiabetic No MSN09 Up Axonal intermediate filament dynamics 0.007514323 8 NaN NEFH;NES
pioglitazone Antidiabetic No MSN02 Down Basement membrane assembly and organization 0.022419283 9 NaN COL8A2;HSPG2
pioglitazone Antidiabetic No MSN01 Up Biglycan synthesis 0.021347918 11 NaN BGN
pioglitazone Antidiabetic No MSN02 Up Biglycan synthesis 0.021083275 12 NaN BGN
pioglitazone Antidiabetic No MSN05 Up Biglycan synthesis 0.02390614 12.5 NaN BGN
pioglitazone Antidiabetic No MSN08 Up Biglycan synthesis 0.021347918 9 NaN BGN
pioglitazone Antidiabetic No MSN09 Up Biglycan synthesis 0.019583627 14 NaN BGN
pioglitazone Antidiabetic No MSN05 Up Cardiomyocyte repolarization during action potential and hyperpolarization 0.042882493 17 NaN KCNIP2;KCNJ2
pioglitazone Antidiabetic No MSN01 Down CCN intercellular signaling protein family receptor signaling 0.005350837 5 NaN CTGF;CYR61
pioglitazone Antidiabetic No MSN02 Down CCN intercellular signaling protein family receptor signaling 0.005389806 5.5 NaN CTGF;CYR61
pioglitazone Antidiabetic No MSN08 Down CCN intercellular signaling protein family receptor signaling 0.000101352 2 NaN CTGF;CYR61;NOV
pioglitazone Antidiabetic No MSN09 Down CCN intercellular signaling protein family receptor signaling 0.005827311 8 NaN CTGF;CYR61
pioglitazone Antidiabetic No MSN01 Down Cell cycle arrest in response to DNA damage 0.018503677 8 NaN CDKN1A;H2AFX;UHRF1
pioglitazone Antidiabetic No MSN09 Down Cell cycle arrest in response to DNA damage 0.020755752 10 NaN BBC3;CDKN1A;H2AFX
pioglitazone Antidiabetic No MSN01 Down Cellular cholesterol uptake and efflux 0.036831666 16.5 NaN ARL4C;SCARA3
pioglitazone Antidiabetic No MSN02 Down Cellular cholesterol uptake and efflux 0.037082638 17.5 NaN ARL4C;SCARA3
pioglitazone Antidiabetic No MSN09 Down Cellular cholesterol uptake and efflux 0.039888032 19.5 NaN ARL4C;SCARA3
pioglitazone Antidiabetic No MSN09 Down Centrosome separation 0.02416119 11 NaN NEK6;SPAG5
pioglitazone Antidiabetic No MSN08 Up Chaperone-mediated autophagy 0.042241946 13.5 NaN HSPA8
pioglitazone Antidiabetic No MSN01 Up Cholesterol-sensitive control of SREBP activation 0.006432927 5.5 NaN INSIG1;SREBF1
pioglitazone Antidiabetic No MSN02 Up Cholesterol-sensitive control of SREBP activation 0.006278564 5.5 NaN INSIG1;SREBF1
pioglitazone Antidiabetic No MSN09 Up Cholesterol-sensitive control of SREBP activation 0.00543729 6.5 NaN INSIG1;SREBF1
pioglitazone Antidiabetic No MSN01 Down Classical complement pathway 0.000430925 3 NaN C1QA;C1QB;C1QC
pioglitazone Antidiabetic No MSN02 Down Classical complement pathway 1.04E-05 2 NaN C1QA;C1QB;C1QC;C1R
pioglitazone Antidiabetic No MSN08 Down Classical complement pathway 0.000343307 3 NaN C1QB;C1QC;C1R
pioglitazone Antidiabetic No MSN09 Down Classical complement pathway 1.22E-05 2 NaN C1QA;C1QB;C1QC;C1R
pioglitazone Antidiabetic No MSN01 Down Collagen fibril organization by fibril-associated bridges 0.007900936 6.5 NaN COL12A1;COL14A1
pioglitazone Antidiabetic No MSN02 Down Collagen fibril organization by fibril-associated bridges 0.007958007 7.5 NaN COL12A1;COL14A1
pioglitazone Antidiabetic No MSN08 Down Collagen fibril organization by fibril-associated bridges 0.006799947 7 NaN COL12A1;COL14A1
pioglitazone Antidiabetic No MSN09 Down Collagen fibril organization by fibril-associated bridges 0.008598393 9 NaN COL12A1;COL14A1
pioglitazone Antidiabetic No MSN01 Down Decorin synthesis 0.023729711 11.5 NaN DCN
pioglitazone Antidiabetic No MSN02 Down Decorin synthesis 0.023817925 12.5 NaN DCN
pioglitazone Antidiabetic No MSN05 Down Decorin synthesis 0.020289344 8 NaN DCN
pioglitazone Antidiabetic No MSN08 Down Decorin synthesis 0.02196542 11 NaN DCN
pioglitazone Antidiabetic No MSN09 Down Decorin synthesis 0.024788285 14.5 NaN DCN
pioglitazone Antidiabetic No MSN08 Up ER unfolded protein response pathway 0.011674098 5 NaN DDIT3;PPP1R15A
phenylephrine Sympathomimetic No MSN01 Up Actin filament bundling and crosslinking 0.03875272 11.5 NaN FLNA;SYNPO;TAGLN
phenylephrine Sympathomimetic No MSN05 Up Actin filament bundling and crosslinking 0.026192093 9 NaN FLNB;TAGLN;USH1C
phenylephrine Sympathomimetic No MSN06 Up Actin filament bundling and crosslinking 0.022080775 11 NaN SYNPO;TAGLN;USH1C
phenylephrine Sympathomimetic No MSN08 Up Actin filament bundling and crosslinking 0.025011128 10.5 NaN FLNB;TAGLN;USH1C
phenylephrine Sympathomimetic No MSN09 Up Actin filament bundling and crosslinking 0.021433264 10 NaN FLNB;TAGLN;USH1C
phenylephrine Sympathomimetic No MSN05 Up Actin polymerization 0.020226356 5 NaN ACTA1;CYFIP2;FMNL2;HSPB1
phenylephrine Sympathomimetic No MSN08 Up Actin polymerization 0.003464661 3 NaN ABRA;ACTA1;CYFIP2;ENAH;FMNL2
phenylephrine Sympathomimetic No MSN09 Up Actin polymerization 0.002684457 2 NaN ABRA;ACTA1;CYFIP2;ENAH;FMNL2
phenylephrine Sympathomimetic No MSN01 Up Adrenergic receptor signaling 0.03875272 11.5 NaN PPP1R9B;RASD1;RGS4
phenylephrine Sympathomimetic No MSN01 Down Albumin mediated blood protein transport 0.014555399 9 NaN ALB
phenylephrine Sympathomimetic No MSN05 Down Albumin mediated blood protein transport 0.019936486 14 NaN ALB
phenylephrine Sympathomimetic No MSN06 Down Albumin mediated blood protein transport 0.021347918 15 NaN ALB
phenylephrine Sympathomimetic No MSN08 Down Albumin mediated blood protein transport 0.020465773 14.5 NaN ALB
phenylephrine Sympathomimetic No MSN09 Down Albumin mediated blood protein transport 0.021612562 13.5 NaN ALB
phenylephrine Sympathomimetic No MSN06 Down Alternative complement pathway 0.004349703 8.5 NaN C1S;CFH
phenylephrine Sympathomimetic No MSN08 Down Alternative complement pathway 0.004004069 9.5 NaN C1S;CFH
phenylephrine Sympathomimetic No MSN05 Down Antigen presentation via MHC class I molecules 0.016025171 10 NaN HLA-B;HLA-C
phenylephrine Sympathomimetic No MSN06 Down Antigen presentation via MHC class I molecules 0.01824187 13 NaN HLA-B;HLA-C
phenylephrine Sympathomimetic No MSN05 Up Biglycan synthesis 0.024964714 7.5 NaN BGN
phenylephrine Sympathomimetic No MSN08 Up Biglycan synthesis 0.024523641 8.5 NaN BGN
phenylephrine Sympathomimetic No MSN09 Up Biglycan synthesis 0.023112209 11.5 NaN BGN
phenylephrine Sympathomimetic No MSN06 Up Cardiomyocyte depolarization during action potential 0.023376853 12.5 NaN SCN5A
phenylephrine Sympathomimetic No MSN01 Down Cardiomyocyte repolarization during action potential and hyperpolarization 0.017084419 13 NaN KCNA1;KCNQ5
phenylephrine Sympathomimetic No MSN05 Down Cardiomyocyte repolarization during action potential and hyperpolarization 0.030757337 19 NaN KCNA1;KCNJ2
phenylephrine Sympathomimetic No MSN08 Down Cardiomyocyte repolarization during action potential and hyperpolarization 0.032279631 16 NaN KCNA1;KCNJ2
phenylephrine Sympathomimetic No MSN08 Up CCN intercellular signaling protein family receptor signaling 0.005706386 6 NaN CYR61;NOV
phenylephrine Sympathomimetic No MSN09 Up CCN intercellular signaling protein family receptor signaling 0.005081819 5 NaN CYR61;NOV
phenylephrine Sympathomimetic No MSN06 Down CD44-Mediated leukocyte rolling 0.042241946 18.5 NaN CD44
phenylephrine Sympathomimetic No MSN08 Up Cellular fatty acid uptake 0.048447984 14.5 NaN CD36
phenylephrine Sympathomimetic No MSN09 Up Cellular fatty acid uptake 0.045692235 17.5 NaN CD36
phenylephrine Sympathomimetic No MSN05 Down Centrosome maturation 0.022896737 17 NaN PLK1;TPX2
phenylephrine Sympathomimetic No MSN05 Down Centrosome separation 0.000846027 3.5 NaN CDK1;ESPL1;KIF11
phenylephrine Sympathomimetic No MSN08 Down Centrosome separation 0.000912967 4.5 NaN ESPL1;KIF11;NEK6
phenylephrine Sympathomimetic No MSN09 Down Centrosome separation 0.018671484 12 NaN ESPL1;NEK6
phenylephrine Sympathomimetic No MSN05 Up Chaperone-mediated autophagy 0.049308339 13 NaN HSPA8
phenylephrine Sympathomimetic No MSN06 Up Cholesterol synthesis 0.010727279 7 NaN FDFT1;NSDHL;SQLE
phenylephrine Sympathomimetic No MSN09 Down Cholesterol synthesis 0.008661663 10 NaN DHCR24;DHCR7;MVD
phenylephrine Sympathomimetic No MSN06 Up Chondroitin sulfate and dermatan sulfate synthesis 0.010579453 5.5 NaN CHST11;SERPIND1
phenylephrine Sympathomimetic No MSN06 Down Classical complement pathway 0.000315641 1 NaN C1QB;C1QC;C1S
phenylephrine Sympathomimetic No MSN08 Down Classical complement pathway 0.000278703 2 NaN C1QB;C1QC;C1S
phenylephrine Sympathomimetic No MSN09 Down Classical complement pathway 0.000327312 2 NaN C1QB;C1QC;C1S
phenylephrine Sympathomimetic No MSN05 Up Collagen fibril organization by fibril-associated bridges 0.0087173 2.5 NaN COL12A1;COL14A1
phenylephrine Sympathomimetic No MSN09 Up Collagen fibril organization by fibril-associated bridges 0.007506811 6.5 NaN COL14A1;COL9A2
phenylephrine Sympathomimetic No MSN01 Down Collagen fibril organization by fibril-associated bridges 5.86E-05 2 NaN COL9A1;COL9A2;COL9A3
phenylephrine Sympathomimetic No MSN05 Down Collagen fibril organization by fibril-associated bridges 0.0056301 7 NaN COL9A1;COL9A3
phenylephrine Sympathomimetic No MSN08 Down Collagen fibril organization by fibril-associated bridges 0.005925252 11 NaN COL9A1;COL9A3
phenylephrine Sympathomimetic No MSN09 Down Collagen fibril organization by fibril-associated bridges 0.00658905 9 NaN COL9A1;COL9A3
phenylephrine Sympathomimetic No MSN01 Down Decorin synthesis 0.014555399 9 NaN DCN
phenylephrine Sympathomimetic No MSN05 Down Decorin synthesis 0.019936486 14 NaN DCN
phenylephrine Sympathomimetic No MSN06 Down Decorin synthesis 0.021347918 15 NaN DCN
phenylephrine Sympathomimetic No MSN01 Up Desaturation of fatty acids 0.016104585 8.5 NaN FADS2;FADS3
phenylephrine Sympathomimetic No MSN01 Up Electron transport chain 0.045993416 14 NaN UQCR10;UQCR11
phenylephrine Sympathomimetic No MSN05 Up Epithelial intermediate filament dynamics 0.015743705 4 NaN KRT19;KRT7
phenylephrine Sympathomimetic No MSN06 Up Epithelial intermediate filament dynamics 0.013889809 8.5 NaN KRT19;KRT7
phenylephrine Sympathomimetic No MSN08 Up Epithelial intermediate filament dynamics 0.015218327 7 NaN KRT19;KRT7
phenylephrine Sympathomimetic No MSN09 Up Epithelial intermediate filament dynamics 0.013590977 9 NaN KRT19;KRT7
phenylephrine Sympathomimetic No MSN01 Up ER unfolded protein response pathway 0.001227822 3 NaN ATF4;DDIT3;HERPUD1
phenylephrine Sympathomimetic No MSN06 Up ER unfolded protein response pathway 0.013889809 8.5 NaN DDIT3;HERPUD1
phenylephrine Sympathomimetic No MSN05 Down Mitotic spindle assembly 0.026709042 18 NaN DLGAP5;TPX2
phenylephrine Sympathomimetic No MSN05 Down Mitotic spindle disassembly 0.019936486 14 NaN CDK1
phenylephrine Sympathomimetic No MSN01 Up Muscarinic receptor signaling 0.011727351 5.5 NaN CHRM4;RGS4
phenylephrine Sympathomimetic No MSN01 Up Natriuretic peptide receptor signaling 0.011727351 5.5 NaN NPPA;NPPB
phenylephrine Sympathomimetic No MSN05 Up Natriuretic peptide receptor signaling 0.0087173 2.5 NaN NPPA;NPPB
phenylephrine Sympathomimetic No MSN06 Up Natriuretic peptide receptor signaling 0.007674569 4 NaN NPPA;NPR3
phenylephrine Sympathomimetic No MSN08 Up Natriuretic peptide receptor signaling 0.000276247 1 NaN NPPA;NPPB;NPR3
phenylephrine Sympathomimetic No MSN09 Up Natriuretic peptide receptor signaling 0.007506811 6.5 NaN NPPA;NPR3
phenylephrine Sympathomimetic No MSN05 Up Nodal growth differentiation factor receptor signaling 0.046379866 10.5 NaN LEFTY2;TGIF1
phenylephrine Sympathomimetic No MSN06 Up Nodal growth differentiation factor receptor signaling 0.041174069 15.5 NaN LEFTY2;NCLN
phenylephrine Sympathomimetic No MSN01 Up Notch receptor signaling 0.01930118 10 NaN JAG2;NOTCH1;NOTCH3
phenylephrine Sympathomimetic No MSN01 Down Osteopontin receptor signaling 0.014555399 9 NaN SPP1
phenylephrine Sympathomimetic No MSN06 Down Osteopontin receptor signaling 0.021347918 15 NaN SPP1
phenylephrine Sympathomimetic No MSN08 Down Osteopontin receptor signaling 0.020465773 14.5 NaN SPP1
phenylephrine Sympathomimetic No MSN09 Down Osteopontin receptor signaling 0.021612562 13.5 NaN SPP1
phenylephrine Sympathomimetic No MSN01 Up Platelet-derived growth factor receptor signaling 0.03906502 13 NaN PDGFB;TNK2
phenylephrine Sympathomimetic No MSN06 Up Platelet-derived growth factor receptor signaling 0.001813406 2 NaN PDGFB;PDGFRB;TNK2
phenylephrine Sympathomimetic No MSN08 Up Platelet-derived growth factor receptor signaling 0.028480684 12 NaN PDGFB;PDGFRB
phenylephrine Sympathomimetic No MSN09 Up Platelet-derived growth factor receptor signaling 0.02550613 13 NaN PDGFB;PDGFRB
phenylephrine Sympathomimetic No MSN01 Down Platelet-derived growth factor receptor signaling 0.010624967 5 NaN PDGFD;RGS5
phenylephrine Sympathomimetic No MSN05 Down Platelet-derived growth factor receptor signaling 0.019331602 11 NaN PDGFD;PDGFRA
phenylephrine Sympathomimetic No MSN08 Down Platelet-derived growth factor receptor signaling 0.02030943 13 NaN PDGFD;PDGFRA
phenylephrine Sympathomimetic No MSN01 Down Procollagen cleavage into collagen 0.043037442 19 NaN PCOLCE
phenylephrine Sympathomimetic No MSN01 Down Progesterone receptor signaling 0.014555399 9 NaN PGR
phenylephrine Sympathomimetic No MSN01 Down Prostaglandin PGF2 alpha receptor signaling 0.028900203 15.5 NaN PTGFR
phenylephrine Sympathomimetic No MSN05 Down Prostaglandin PGF2 alpha receptor signaling 0.039477231 21.5 NaN PTGFR
phenylephrine Sympathomimetic No MSN06 Down Prostaglandin PGF2 alpha receptor signaling 0.042241946 18.5 NaN PTGFR
phenylephrine Sympathomimetic No MSN08 Down Prostaglandin PGF2 alpha receptor signaling 0.040514466 18 NaN PTGFR
phenylephrine Sympathomimetic No MSN09 Down Prostaglandin PGF2 alpha receptor signaling 0.042759886 17 NaN PTGFR
phenylephrine Sympathomimetic No MSN01 Up Protein polyubiquitination 0.010329076 4 NaN ISG15;UBE2S;UCHL1
phenylephrine Sympathomimetic No MSN09 Up Regulation of coagulation cascade by protein C 0.003096266 3.5 NaN PROS1;THBD
phenylephrine Sympathomimetic No MSN06 Down Removal of caspase inhibition 0.042241946 18.5 NaN XAF1
phenylephrine Sympathomimetic No MSN08 Down Removal of caspase inhibition 0.040514466 18 NaN XAF1
phenylephrine Sympathomimetic No MSN09 Down Removal of caspase inhibition 0.042759886 17 NaN XAF1
phenylephrine Sympathomimetic No MSN01 Down Retinol metabolism 0.014783725 12 NaN ALDH1A1;ALDH1A3
phenylephrine Sympathomimetic No MSN05 Down Retinol metabolism 9.55E-05 2 NaN ALDH1A1;ALDH1A3;DHRS3;TTR
phenylephrine Sympathomimetic No MSN06 Down Retinol metabolism 0.002345434 5 NaN DHRS3;RBP1;TTR
phenylephrine Sympathomimetic No MSN08 Down Retinol metabolism 0.002079214 7 NaN DHRS3;RBP1;TTR
phenylephrine Sympathomimetic No MSN09 Down Retinol metabolism 0.00242926 5 NaN DHRS3;RBP1;TTR
phenylephrine Sympathomimetic No MSN01 Up Serine and glycine metabolism 0.000197902 2 NaN PHGDH;PSAT1;SHMT2;SLC1A5
phenylephrine Sympathomimetic No MSN05 Down Serine and glycine metabolism 0.001146233 5 NaN PHGDH;PSAT1;SHMT2
phenylephrine Sympathomimetic No MSN08 Down Serine and glycine metabolism 5.04E-05 1 NaN PHGDH;PSAT1;SHMT2;SLC1A5
phenylephrine Sympathomimetic No MSN09 Down Serine and glycine metabolism 6.23E-05 1 NaN PHGDH;PSAT1;SHMT2;SLC1A5
phenylephrine Sympathomimetic No MSN05 Down Serotonin inactivation 0.039477231 21.5 NaN MAOA
phenylephrine Sympathomimetic No MSN06 Down Serotonin inactivation 0.00045389 2 NaN MAOA;MAOB
phenylephrine Sympathomimetic No MSN08 Down Serotonin inactivation 0.000417079 3 NaN MAOA;MAOB
phenylephrine Sympathomimetic No MSN09 Down Serotonin inactivation 0.000465237 3 NaN MAOA;MAOB
phenylephrine Sympathomimetic No MSN05 Down Sister chromatid attachment to mitotic spindle 0.039477231 21.5 NaN NUF2
phenylephrine Sympathomimetic No MSN09 Up Sodium transmembrane transport 0.036972701 14 NaN ATP1A2;SCN1A;SCN2A
phenylephrine Sympathomimetic No MSN06 Down Syndecan ectodomain shedding 0.002647061 6.5 NaN ADAMTS1;MMP9
phenylephrine Sympathomimetic No MSN05 Down Syndecan receptor signaling 0.003803269 6 NaN SDC1;SDC3
phenylephrine Sympathomimetic No MSN06 Down Syndecan receptor signaling 0.004349703 8.5 NaN SDC1;SDC3
phenylephrine Sympathomimetic No MSN08 Down Syndecan receptor signaling 0.004004069 9.5 NaN SDC1;SDC3
phenylephrine Sympathomimetic No MSN09 Down Syndecan receptor signaling 0.004456057 8 NaN SDC1;SDC3
phenylephrine Sympathomimetic No MSN01 Up Thin myofilament organization 2.30E-05 1 NaN ACTA1;TNNI3;TPM2;TPM4
phenylephrine Sympathomimetic No MSN05 Up Thin myofilament organization 0.000500164 1 NaN ACTA1;LMOD3;TPM2
phenylephrine Sympathomimetic No MSN06 Up Thin myofilament organization 0.010579453 5.5 NaN ACTA1;TPM2
phenylephrine Sympathomimetic No MSN08 Up Thin myofilament organization 0.000474665 2 NaN ACTA1;LMOD3;TPM2
phenylephrine Sympathomimetic No MSN09 Up Thin myofilament organization 0.010350023 8 NaN ACTA1;LMOD3
phenylephrine Sympathomimetic No MSN06 Up Thrombospondin receptor signaling 0.003166583 3 NaN THBS2;THBS4
phenylephrine Sympathomimetic No MSN08 Up Thrombospondin receptor signaling 0.003480103 4 NaN THBS2;THBS4
phenylephrine Sympathomimetic No MSN09 Up Thrombospondin receptor signaling 0.003096266 3.5 NaN THBS2;THBS4
phenylephrine Sympathomimetic No MSN06 Up Tight junction organization 0.044377602 17 NaN CGN;CLDN6;CRB2
phenylephrine Sympathomimetic No MSN05 Up Tropoelastin synthesis 0.024964714 7.5 NaN ELN
phenylephrine Sympathomimetic No MSN06 Up Tropoelastin synthesis 0.023376853 12.5 NaN ELN
phenylephrine Sympathomimetic No MSN08 Up Tropoelastin synthesis 0.024523641 8.5 NaN ELN
phenylephrine Sympathomimetic No MSN09 Up Tropoelastin synthesis 0.023112209 11.5 NaN ELN
phenylephrine Sympathomimetic No MSN01 Down Tropoelastin synthesis 0.014555399 9 NaN ELN
phenylephrine Sympathomimetic No MSN01 Up Vascular endothelial growth factor receptor signaling 0.016104585 8.5 NaN VEGFA;VEGFB
phenylephrine Sympathomimetic No MSN08 Up Vasoactive intestinal peptide receptor signaling 0.048447984 14.5 NaN VIPR2
phenylephrine Sympathomimetic No MSN09 Up Vasoactive intestinal peptide receptor signaling 0.045692235 17.5 NaN VIPR2
phenylephrine Sympathomimetic No MSN01 Down Vasoactive intestinal peptide receptor signaling 0.028900203 15.5 NaN VIPR2
phenylephrine Sympathomimetic No MSN05 Down Versican receptor signaling 0.039477231 21.5 NaN VCAN
phenylephrine Sympathomimetic No MSN05 Down Versican synthesis 0.019936486 14 NaN VCAN
phenylephrine Sympathomimetic No MSN01 Down Extracellular matrix breakdown and membrane shedding by adamalysins 0.004895688 4 NaN ADAM12;ADAMTS1;ADAMTS5
phenylephrine Sympathomimetic No MSN06 Down Extracellular matrix breakdown and membrane shedding by adamalysins 0.001537967 4 NaN ADAMTS1;ADAMTS12;ADAMTS5;ADAMTS6
phenylephrine Sympathomimetic No MSN08 Down Extracellular matrix breakdown and membrane shedding by adamalysins 0.012470268 12 NaN ADAM33;ADAMTS12;ADAMTS5
phenylephrine Sympathomimetic No MSN06 Down Extracellular matrix breakdown by heparanases and sulfatases 0.002647061 6.5 NaN SULF1;SULF2
phenylephrine Sympathomimetic No MSN08 Down Extracellular matrix breakdown by heparanases and sulfatases 0.002435279 8 NaN SULF1;SULF2
phenylephrine Sympathomimetic No MSN09 Down Extracellular matrix breakdown by heparanases and sulfatases 0.002712266 7 NaN SULF1;SULF2
phenylephrine Sympathomimetic No MSN05 Down Extracellular matrix breakdown by matrix metalloproteases 0.012989342 9 NaN MMP1;MMP2
phenylephrine Sympathomimetic No MSN06 Down Extracellular matrix breakdown by matrix metalloproteases 0.014799877 12 NaN MMP1;MMP9
phenylephrine Sympathomimetic No MSN09 Down Extracellular matrix breakdown by matrix metalloproteases 0.015151071 11 NaN MMP1;MMP2
phenylephrine Sympathomimetic No MSN05 Up Fibrillar collagen core structure organization 0.024483872 6 NaN COL2A1;COL5A2
phenylephrine Sympathomimetic No MSN01 Down Fibrillar collagen core structure organization 8.49E-06 1 NaN COL11A1;COL11A2;COL1A2;COL3A1
phenylephrine Sympathomimetic No MSN05 Down Fibrillar collagen core structure organization 0.000846027 3.5 NaN COL1A1;COL1A2;COL3A1
phenylephrine Sympathomimetic No MSN06 Down Fibrillar collagen core structure organization 0.001031906 3 NaN COL1A1;COL1A2;COL3A1
phenylephrine Sympathomimetic No MSN08 Down Fibrillar collagen core structure organization 0.000912967 4.5 NaN COL1A1;COL1A2;COL3A1
phenylephrine Sympathomimetic No MSN09 Down Fibrillar collagen core structure organization 0.001069423 4 NaN COL1A1;COL1A2;COL3A1
phenylephrine Sympathomimetic No MSN06 Up Filopodium organization 0.017785355 10 NaN FMNL2;MYL9;TNK2
phenylephrine Sympathomimetic No MSN06 Up Glutamate and glutamine metabolism 0.035834633 14 NaN SLC1A3;SLC7A5
phenylephrine Sympathomimetic No MSN01 Down Granulocyte macrophage colony-stimulating factor receptor signaling 0.028900203 15.5 NaN JAK2
phenylephrine Sympathomimetic No MSN06 Down Granulocyte macrophage colony-stimulating factor receptor signaling 0.042241946 18.5 NaN JUND
phenylephrine Sympathomimetic No MSN01 Down Heparin-binding EGF-like growth factor receptor signaling 0.043037442 19 NaN HBEGF
phenylephrine Sympathomimetic No MSN08 Up Hippo signaling 0.025011128 10.5 NaN AMOTL1;CRB2;PTPN14
phenylephrine Sympathomimetic No MSN05 Down Hyaluronan-mediated motility receptor signaling 0.019936486 14 NaN HMMR
phenylephrine Sympathomimetic No MSN06 Up Inhibition of amyloid aggregation, amyloid degradation and uptake 0.001608121 1 NaN A2M;MME
phenylephrine Sympathomimetic No MSN09 Up Inhibition of amyloid aggregation, amyloid degradation and uptake 0.001572131 1 NaN A2M;MME
phenylephrine Sympathomimetic No MSN01 Down Inhibition of amyloid aggregation, amyloid degradation and uptake 0.000625725 3 NaN MME;PLAT
phenylephrine Sympathomimetic No MSN08 Down Inhibition of apoptosis 0.001623789 6 NaN BIRC5;IFI6;XAF1
phenylephrine Sympathomimetic No MSN09 Down Inhibition of apoptosis 0.026619198 15 NaN BIRC5;XAF1
phenylephrine Sympathomimetic No MSN01 Down Intracellular bridge assembly 0.043037442 19 NaN NEK7
phenylephrine Sympathomimetic No MSN05 Up JAK-STAT signaling pathway 0.046379866 10.5 NaN SOCS3;STAT4
phenylephrine Sympathomimetic No MSN06 Up JAK-STAT signaling pathway 0.041174069 15.5 NaN SOCS2;STAT4
phenylephrine Sympathomimetic No MSN08 Up JAK-STAT signaling pathway 0.004345619 5 NaN SOCS2;STAT3;STAT4
phenylephrine Sympathomimetic No MSN09 Up JAK-STAT signaling pathway 0.040330112 15 NaN SOCS2;STAT4
phenylephrine Sympathomimetic No MSN08 Down Lipogenesis 0.040514466 18 NaN FASN
phenylephrine Sympathomimetic No MSN09 Down Lipogenesis 0.042759886 17 NaN FASN
phenylephrine Sympathomimetic No MSN01 Up Mammalian target of rapamycin signaling pathway 0.012276145 7 NaN DDIT4;EIF4EBP1;FKBP8
phenylephrine Sympathomimetic No MSN05 Up Methionine cycle 0.049308339 13 NaN BHMT
phenylephrine Sympathomimetic No MSN06 Up Methionine cycle 0.046209242 18.5 NaN BHMT
phenylephrine Sympathomimetic No MSN08 Up Methionine cycle 0.048447984 14.5 NaN BHMT
phenylephrine Sympathomimetic No MSN09 Up Methionine cycle 0.045692235 17.5 NaN BHMT
phenylephrine Sympathomimetic No MSN01 Down Methionine cycle 0.028900203 15.5 NaN BHMT
phenylephrine Sympathomimetic No MSN05 Up Microfibril scaffold organization 0.049308339 13 NaN FBN1
phenylephrine Sympathomimetic No MSN06 Up Microfibril scaffold organization 0.046209242 18.5 NaN FBN1
phenylephrine Sympathomimetic No MSN08 Up Microfibril scaffold organization 0.048447984 14.5 NaN FBN1
phenylephrine Sympathomimetic No MSN09 Up Microfibril scaffold organization 0.045692235 17.5 NaN FBN1
phenylephrine Sympathomimetic No MSN05 Down Mitotic H3 phosphorylation and dephosphorylation 7.59E-05 1 NaN AURKB;CCNA2;INCENP
phenylephrine Sympathomimetic No MSN01 Down WNT-Beta-catenin signaling pathway 0.013976683 6 NaN FRZB;FZD10;PAX6;SFRP2
phenylephrine Sympathomimetic No MSN05 Down WNT-Beta-catenin signaling pathway 0.008849032 8 NaN FRZB;FZD10;FZD7;PAX6;SFRP2
phenylephrine Sympathomimetic No MSN06 Down WNT-Beta-catenin signaling pathway 0.011667148 11 NaN APCDD1;FRZB;FZD7;SFRP2;SFRP5
phenylephrine Sympathomimetic No MSN08 Down WNT-Beta-catenin signaling pathway 0.041836543 21 NaN APCDD1;FRZB;FZD7;SFRP2
phenylephrine Sympathomimetic No MSN09 Down WNT-Beta-catenin signaling pathway 0.002522047 6 NaN APCDD1;FRZB;FZD7;SFRP2;SFRP5;WNT9A
phenylephrine Sympathomimetic No MSN06 Down Z-disc organization 0.004380348 10 NaN DES;LDB3;PDLIM3
phenylephrine Sympathomimetic No MSN08 Down Z-disc organization 0.041446435 20 NaN DES;LDB3
pazopanib Kinase inhibitor Yes MSN01 Down WNT-Beta-catenin signaling pathway 0.006287892 2 NaN APCDD1;FZD1;FZD8;SFRP5;TCF7L2
pazopanib Kinase inhibitor Yes MSN05 Down WNT-Beta-catenin signaling pathway 0.007314551 10 NaN APCDD1;CTHRC1;DKK2;FZD2;FZD8;SFRP5
pazopanib Kinase inhibitor Yes MSN06 Down WNT-Beta-catenin signaling pathway 0.041284933 12 NaN APCDD1;CDK14;FZD8;SFRP5
pazopanib Kinase inhibitor Yes MSN08 Down Z-disc organization 0.048469694 12 NaN PDLIM3;TCAP
pazopanib Kinase inhibitor Yes MSN09 Down Myofibril formation 0.026793335 9 6 Down by cardiotoxic TKIs KLHL41;XIRP1
pazopanib Kinase inhibitor Yes MSN06 Up Osteonectin receptor signaling 0.002647061 6 NaN SMOC2;SPARC
pazopanib Kinase inhibitor Yes MSN05 Down Osteopontin receptor signaling 0.026905434 14.5 NaN SPP1
pazopanib Kinase inhibitor Yes MSN05 Up Peroxisome proliferator-activated receptor alpha signaling 0.032027317 12 NaN PPARA
pazopanib Kinase inhibitor Yes MSN08 Up Peroxisome proliferator-activated receptor alpha signaling 0.041723865 15.5 NaN PPARA
pazopanib Kinase inhibitor Yes MSN09 Up Peroxisome proliferator-activated receptor alpha signaling 0.031506482 10.5 NaN PPARA
pazopanib Kinase inhibitor Yes MSN06 Up Platelet-derived growth factor receptor signaling 0.021985266 15.5 NaN PDGFD;PDGFRB
pazopanib Kinase inhibitor Yes MSN06 Down Platelet-derived growth factor receptor signaling 0.020145007 9 14 Down by cardiotoxic TKIs PDGFB;RGS5
pazopanib Kinase inhibitor Yes MSN05 Down Progesterone receptor signaling 0.026905434 14.5 NaN PGR
pazopanib Kinase inhibitor Yes MSN09 Down Progesterone receptor signaling 0.026199718 7.5 NaN PGR
pazopanib Kinase inhibitor Yes MSN01 Up Protein folding in mitochondria 0.001644513 5 NaN HSPD1;PPIF
pazopanib Kinase inhibitor Yes MSN05 Up Protein folding in mitochondria 0.04765631 15 NaN PPIF
pazopanib Kinase inhibitor Yes MSN09 Up Protein folding in mitochondria 0.046887533 12.5 NaN PPIF
pazopanib Kinase inhibitor Yes MSN06 Down Recycling endosome dynamics 0.018799197 8 NaN EHD3;RAB15;S100A10
pazopanib Kinase inhibitor Yes MSN09 Down Recycling endosome dynamics 0.035973541 10 NaN RAB15;S100A10;SNAP23
pazopanib Kinase inhibitor Yes MSN09 Down Retinoic acid receptor signaling 0.044111632 11 NaN NR4A1;TBL1XR1
pazopanib Kinase inhibitor Yes MSN06 Up Retinol metabolism 0.03031943 17.5 NaN ALDH1A1;DHRS3
pazopanib Kinase inhibitor Yes MSN08 Up Retinol metabolism 0.029628054 14 NaN DHRS3;RPE65
pazopanib Kinase inhibitor Yes MSN05 Down Retinol metabolism 0.000303147 2 NaN ALDH1A1;ALDH1A2;ALDH1A3;RDH10
pazopanib Kinase inhibitor Yes MSN06 Down Semaphorin signaling 0.004822239 2 NaN CRMP1;DPYSL4;PLXNA2;PLXNC1
pazopanib Kinase inhibitor Yes MSN08 Down Semaphorin signaling 0.039540041 9 NaN CRMP1;DPYSL3;SEMA6B
pazopanib Kinase inhibitor Yes MSN01 Up Serine and glycine metabolism 8.84E-05 4 19 Up by cardiotoxic TKIs PHGDH;PSAT1;SHMT2;SLC1A5
pazopanib Kinase inhibitor Yes MSN05 Up Serine and glycine metabolism 0.000620716 1 19 Up by cardiotoxic TKIs AMT;PHGDH;SHMT2
pazopanib Kinase inhibitor Yes MSN06 Up Serine and glycine metabolism 5.94E-05 3 19 Up by cardiotoxic TKIs PHGDH;PSAT1;SHMT2;SLC1A5
pazopanib Kinase inhibitor Yes MSN08 Up Serine and glycine metabolism 0.001347236 5 19 Up by cardiotoxic TKIs PHGDH;PSAT1;SHMT2
pazopanib Kinase inhibitor Yes MSN09 Up Serine and glycine metabolism 1.86E-05 1 19 Up by cardiotoxic TKIs PHGDH;PSAT1;SHMT2;SLC1A5
pazopanib Kinase inhibitor Yes MSN05 Up Serotonin inactivation 0.032027317 12 NaN MAOB
pazopanib Kinase inhibitor Yes MSN06 Up Serotonin inactivation 0.042241946 19.5 NaN MAOB
pazopanib Kinase inhibitor Yes MSN08 Down Tenascin receptor signaling 0.002889904 2 NaN TENM1;TNC
pazopanib Kinase inhibitor Yes MSN01 Up Thin myofilament organization 0.010811186 11 NaN TNNI3;TPM2
pazopanib Kinase inhibitor Yes MSN05 Down Tight junction organization 0.002000361 3 NaN CLDN1;CLDN6;CRB2;EMP1;MPP5
pazopanib Kinase inhibitor Yes MSN01 Up Transamination pathways 0.010811186 11 25 Up by cardiotoxic TKIs GOT1;GOT2
pazopanib Kinase inhibitor Yes MSN05 Up Transamination pathways 0.005160336 5.5 25 Up by cardiotoxic TKIs GOT1;GOT2
pazopanib Kinase inhibitor Yes MSN06 Up Transamination pathways 0.008879841 10 25 Up by cardiotoxic TKIs BCAT1;GOT1
pazopanib Kinase inhibitor Yes MSN08 Up Transamination pathways 0.008668292 9.5 25 Up by cardiotoxic TKIs GOT1;GOT2
pazopanib Kinase inhibitor Yes MSN01 Up Translation initiation 0.01976951 15 NaN EIF1;EIF2S2;EIF3K;EIF4EBP1
pazopanib Kinase inhibitor Yes MSN01 Up Transmembrane glucose transport 0.003237663 6 NaN SLC2A3;SLC2A4
pazopanib Kinase inhibitor Yes MSN01 Up Tropoelastin synthesis 0.023641496 18.5 NaN ELN
pazopanib Kinase inhibitor Yes MSN06 Up Tropoelastin synthesis 0.021347918 13 NaN ELN
pazopanib Kinase inhibitor Yes MSN08 Up Tropoelastin synthesis 0.021083275 11.5 NaN ELN
pazopanib Kinase inhibitor Yes MSN05 Down Tropoelastin synthesis 0.026905434 14.5 NaN ELN
pazopanib Kinase inhibitor Yes MSN09 Down Tropoelastin synthesis 0.026199718 7.5 NaN ELN
pazopanib Kinase inhibitor Yes MSN01 Up Vascular endothelial growth factor receptor signaling 0.010811186 11 12 Up by cardiotoxic TKIs VEGFA;VEGFB
pazopanib Kinase inhibitor Yes MSN05 Up Vascular endothelial growth factor receptor signaling 0.005160336 5.5 12 Up by cardiotoxic TKIs VEGFA;VEGFB
pazopanib Kinase inhibitor Yes MSN06 Up Vascular endothelial growth factor receptor signaling 0.008879841 10 12 Up by cardiotoxic TKIs VEGFA;VEGFB
pazopanib Kinase inhibitor Yes MSN08 Up Vascular endothelial growth factor receptor signaling 0.008668292 9.5 12 Up by cardiotoxic TKIs VEGFA;VEGFB
pazopanib Kinase inhibitor Yes MSN06 Down Water transmembrane transport 0.010676413 4 9 Down by cardiotoxic TKIs AQP1;AQP7
pazopanib Kinase inhibitor Yes MSN05 Down Alternative complement pathway 0.006837765 7.5 NaN C3;CFH
pazopanib Kinase inhibitor Yes MSN06 Up Amyloid plaque organization 0.021985266 15.5 NaN APBB2;APOE
pazopanib Kinase inhibitor Yes MSN01 Up Aspartate and arginine metabolism 0.022108594 16.5 NaN ARG2;SLC7A1
pazopanib Kinase inhibitor Yes MSN01 Up Basement membrane attachment to cell surface 0.007844056 8 NaN BSG;ITGA5
pazopanib Kinase inhibitor Yes MSN05 Down Biglycan synthesis 0.026905434 14.5 18 Down by cardiotoxic TKIs BGN
pazopanib Kinase inhibitor Yes MSN08 Down Cardiomyocyte pacemaker current generation 0.012712092 5 NaN CACNA1G;HCN4
pazopanib Kinase inhibitor Yes MSN06 Down Cardiomyocyte repolarization during action potential and hyperpolarization 0.032023829 10 NaN KCND3;KCNQ5
pazopanib Kinase inhibitor Yes MSN08 Down Cardiomyocyte repolarization during action potential and hyperpolarization 0.037839911 8 NaN KCNA5;KCNQ5
pazopanib Kinase inhibitor Yes MSN09 Down Caveolin-mediated endocytosis 0.002016908 2 NaN CAV1;CAV2
pazopanib Kinase inhibitor Yes MSN01 Down CCN intercellular signaling protein family receptor signaling 0.003230669 1 NaN CTGF;CYR61
pazopanib Kinase inhibitor Yes MSN05 Down CCN intercellular signaling protein family receptor signaling 0.006837765 7.5 NaN CTGF;CYR61
pazopanib Kinase inhibitor Yes MSN09 Down CCN intercellular signaling protein family receptor signaling 0.006492473 3 NaN CTGF;CYR61
pazopanib Kinase inhibitor Yes MSN08 Down CD44-Mediated leukocyte rolling 0.044140376 10.5 NaN CD44
pazopanib Kinase inhibitor Yes MSN09 Up Cellular cholesterol uptake and efflux 0.017433217 8 NaN ABCA1;ABCG1
pazopanib Kinase inhibitor Yes MSN01 Up Cholesterol synthesis 0.011059837 13 22 Up by cardiotoxic TKIs DHCR24;DHCR7;EBP
pazopanib Kinase inhibitor Yes MSN06 Up Cholesterol synthesis 5.07E-05 2 22 Up by cardiotoxic TKIs CYP27A1;DHCR24;DHCR7;EBP;MVD
pazopanib Kinase inhibitor Yes MSN09 Up Cholesterol synthesis 0.000244132 2 22 Up by cardiotoxic TKIs DHCR24;DHCR7;LSS;MVD
pazopanib Kinase inhibitor Yes MSN01 Up Cholesterol-sensitive control of SREBP activation 0.007844056 8 15 Up by cardiotoxic TKIs INSIG1;SREBF1
pazopanib Kinase inhibitor Yes MSN05 Up Cholesterol-sensitive control of SREBP activation 0.003725413 3.5 15 Up by cardiotoxic TKIs INSIG1;SREBF1
pazopanib Kinase inhibitor Yes MSN06 Up Cholesterol-sensitive control of SREBP activation 0.006432927 8 15 Up by cardiotoxic TKIs INSIG1;SREBF1
pazopanib Kinase inhibitor Yes MSN08 Up Cholesterol-sensitive control of SREBP activation 0.006278564 7.5 15 Up by cardiotoxic TKIs INSIG1;SREBF1
pazopanib Kinase inhibitor Yes MSN09 Up Cholesterol-sensitive control of SREBP activation 0.003606501 4.5 15 Up by cardiotoxic TKIs INSIG1;SREBF1
pazopanib Kinase inhibitor Yes MSN01 Up Citric acid cycle 2.47E-07 1 1 Up by cardiotoxic TKIs ACO2;CS;OGDH;PDHA1;SDHA;SDHB
pazopanib Kinase inhibitor Yes MSN05 Up Citric acid cycle 0.001050588 2 1 Up by cardiotoxic TKIs ACO2;CS;OGDH
pazopanib Kinase inhibitor Yes MSN08 Up Citric acid cycle 0.000118607 1 1 Up by cardiotoxic TKIs ACO2;CS;OGDH;SDHD
pazopanib Kinase inhibitor Yes MSN09 Up Citric acid cycle 0.001001483 3 1 Up by cardiotoxic TKIs ACO2;CS;OGDH
pazopanib Kinase inhibitor Yes MSN05 Down Collagen fiber crosslinking 0.006837765 7.5 NaN LOX;PXDN
pazopanib Kinase inhibitor Yes MSN05 Down Collagen fibril organization by fibril-associated bridges 0.010075061 11.5 NaN COL12A1;COL9A2
pazopanib Kinase inhibitor Yes MSN09 Down Collagen fibril organization by fibril-associated bridges 0.009570814 4.5 NaN COL12A1;COL19A1
pazopanib Kinase inhibitor Yes MSN06 Up Decorin synthesis 0.021347918 13 NaN DCN
pazopanib Kinase inhibitor Yes MSN06 Up Desaturation of fatty acids 0.008879841 10 11 Up by cardiotoxic TKIs FADS1;SCD
pazopanib Kinase inhibitor Yes MSN08 Up Desaturation of fatty acids 0.000304244 2 11 Up by cardiotoxic TKIs FADS1;FADS2;SCD
pazopanib Kinase inhibitor Yes MSN09 Up Desaturation of fatty acids 0.004996504 6.5 11 Up by cardiotoxic TKIs FADS2;SCD
pazopanib Kinase inhibitor Yes MSN01 Up Electron transport chain 4.92E-06 3 NaN COX7A1;SDHA;SDHB;UQCR10;UQCRQ
pazopanib Kinase inhibitor Yes MSN05 Up Electron transport chain 0.015380525 8 NaN COX7A1;UQCR10
pazopanib Kinase inhibitor Yes MSN08 Up Electron transport chain 0.025418115 13 NaN NDUFA4;SDHD
pazopanib Kinase inhibitor Yes MSN05 Up ER unfolded protein response pathway 0.006807667 7 NaN DDIT3;HERPUD1
pazopanib Kinase inhibitor Yes MSN06 Up ER unfolded protein response pathway 0.00049707 5 NaN ATF4;DDIT3;HERPUD1
pazopanib Kinase inhibitor Yes MSN08 Up ER unfolded protein response pathway 0.000479218 3 NaN ATF4;DDIT3;HERPUD1
pazopanib Kinase inhibitor Yes MSN05 Down Extracellular matrix breakdown and membrane shedding by adamalysins 0.003567478 4 NaN ADAM12;ADAMTS1;ADAMTS12;ADAMTS8
pazopanib Kinase inhibitor Yes MSN06 Down Extracellular matrix breakdown and membrane shedding by adamalysins 0.012326034 5 NaN ADAMTS1;ADAMTS8;ADAMTS9
pazopanib Kinase inhibitor Yes MSN01 Up Extracellular matrix breakdown by cathepsins 0.022108594 16.5 NaN CTSB;CTSL
pazopanib Kinase inhibitor Yes MSN09 Up Extracellular matrix breakdown by serine proteases 0.004996504 6.5 NaN HPN;PRSS8
pazopanib Kinase inhibitor Yes MSN08 Up Fatty acid elongation 0.000707656 4 NaN ELOVL6;ELOVL7;HSD17B12
pazopanib Kinase inhibitor Yes MSN06 Up Fibrillar collagen core structure organization 3.85E-05 1 NaN COL11A1;COL1A1;COL1A2;COL3A1
pazopanib Kinase inhibitor Yes MSN05 Down Fibrillar collagen core structure organization 3.08E-06 1 NaN COL11A1;COL1A1;COL1A2;COL5A1;COL5A2
pazopanib Kinase inhibitor Yes MSN08 Down Fibrillar collagen core structure organization 0.019838394 7 NaN COL2A1;COL5A2
pazopanib Kinase inhibitor Yes MSN06 Down Gap junction organization 0.002574736 1 24 Down by cardiotoxic TKIs GJA5;GJC1;PANX1
pazopanib Kinase inhibitor Yes MSN08 Down Gap junction organization 0.003332429 3 24 Down by cardiotoxic TKIs GJA5;GJD2;PANX1
pazopanib Kinase inhibitor Yes MSN05 Up Gastric inhibitory polypeptide receptor signaling 0.04765631 15 NaN GIPR
pazopanib Kinase inhibitor Yes MSN09 Up Gastric inhibitory polypeptide receptor signaling 0.046887533 12.5 NaN GIPR
pazopanib Kinase inhibitor Yes MSN01 Up Glutamate and glutamine metabolism 0.036581377 21 NaN GLUL;SLC1A5
pazopanib Kinase inhibitor Yes MSN06 Up Glutamate and glutamine metabolism 0.03031943 17.5 NaN GLUL;SLC1A5
pazopanib Kinase inhibitor Yes MSN01 Down Glutamate and glutamine metabolism 0.02287923 4 NaN SLC1A3;SLC38A2
pazopanib Kinase inhibitor Yes MSN01 Up Glycolysis and Gluconeogenesis 6.77E-07 2 NaN ALDOA;ENO1;GPI;PCK2;PFKP;PGAM1;TPI1
pazopanib Kinase inhibitor Yes MSN09 Down Glycolysis and Gluconeogenesis 0.021393109 6 NaN ENO1;HK2;LDHA
pazopanib Kinase inhibitor Yes MSN01 Down Granulocyte macrophage colony-stimulating factor receptor signaling 0.036362165 6 NaN JAK2
pazopanib Kinase inhibitor Yes MSN06 Down Granulocyte macrophage colony-stimulating factor receptor signaling 0.040341633 11 NaN JAK2
pazopanib Kinase inhibitor Yes MSN08 Down Granulocyte macrophage colony-stimulating factor receptor signaling 0.044140376 10.5 NaN JAK2
pazopanib Kinase inhibitor Yes MSN05 Up Heme degradation to bilirubin 0.04765631 15 NaN BLVRB
pazopanib Kinase inhibitor Yes MSN06 Down HIF-1 receptor signaling pathway 0.013543754 6 20 Down by cardiotoxic TKIs CITED2;EGLN3
pazopanib Kinase inhibitor Yes MSN08 Down HIF-1 receptor signaling pathway 0.016105455 6 20 Down by cardiotoxic TKIs CITED2;EGLN3
pazopanib Kinase inhibitor Yes MSN09 Down HIF-1 receptor signaling pathway 0.001329993 1 20 Down by cardiotoxic TKIs CITED2;EGLN1;EGLN3
pazopanib Kinase inhibitor Yes MSN01 Down Hippo signaling 0.011600606 3 13 Down by cardiotoxic TKIs AJUBA;AMOTL1;AMOTL2
pazopanib Kinase inhibitor Yes MSN05 Down Hippo signaling 0.004811885 5 13 Down by cardiotoxic TKIs AJUBA;AMOTL2;CRB2;PTPN14
pazopanib Kinase inhibitor Yes MSN06 Down Hippo signaling 0.015369641 7 13 Down by cardiotoxic TKIs AJUBA;AMOTL1;PTPN14
pazopanib Kinase inhibitor Yes MSN01 Down Intrinsic apoptosis pathway 0.026374299 5 NaN BMF;MCL1
pazopanib Kinase inhibitor Yes MSN05 Up Lipogenesis 0.032027317 12 NaN FASN
pazopanib Kinase inhibitor Yes MSN06 Up Lipogenesis 0.042241946 19.5 NaN FASN
pazopanib Kinase inhibitor Yes MSN08 Up Lipogenesis 0.041723865 15.5 NaN FASN
pazopanib Kinase inhibitor Yes MSN09 Up Lipogenesis 0.031506482 10.5 NaN FASN
pazopanib Kinase inhibitor Yes MSN01 Up Lysosomal glycoprotein degradation 0.007844056 8 2 Up by cardiotoxic TKIs CTSA;IFI30
pazopanib Kinase inhibitor Yes MSN05 Up Lysosomal glycoprotein degradation 0.003725413 3.5 2 Up by cardiotoxic TKIs CTSA;IFI30
pazopanib Kinase inhibitor Yes MSN06 Up Lysosomal glycoprotein degradation 0.000183256 4 2 Up by cardiotoxic TKIs CTSA;IFI30;TPP1
pazopanib Kinase inhibitor Yes MSN08 Up Lysosomal glycoprotein degradation 0.006278564 7.5 2 Up by cardiotoxic TKIs CTSA;IFI30
pazopanib Kinase inhibitor Yes MSN09 Up Lysosomal glycoprotein degradation 0.003606501 4.5 2 Up by cardiotoxic TKIs CTSA;IFI30
pazopanib Kinase inhibitor Yes MSN01 Up Lysosomal glycosaminoglycan degradation 0.031435723 20 NaN ARSB;NAGLU
pazopanib Kinase inhibitor Yes MSN05 Down Macrophage migration inhibitory factor signaling 0.006837765 7.5 NaN ACKR3;CXCR4
pazopanib Kinase inhibitor Yes MSN08 Down Macrophage migration inhibitory factor signaling 0.000106279 1 NaN ACKR3;CXCR2;CXCR4
pazopanib Kinase inhibitor Yes MSN05 Up Mammalian target of rapamycin signaling pathway 0.030066821 10 NaN EIF4EBP1;FLCN
pazopanib Kinase inhibitor Yes MSN06 Up Mammalian target of rapamycin signaling pathway 0.005235988 7 NaN DDIT4;EIF4EBP1;FLCN
pazopanib Kinase inhibitor Yes MSN08 Up Mammalian target of rapamycin signaling pathway 0.005056937 6 NaN DDIT4;EIF4EBP1;FLCN
pazopanib Kinase inhibitor Yes MSN09 Up Mammalian target of rapamycin signaling pathway 0.029162896 9 NaN EIF4EBP1;FLCN
pazopanib Kinase inhibitor Yes MSN01 Down Mammalian target of rapamycin signaling pathway 0.038028136 7 NaN PIK3R1;RICTOR
pazopanib Kinase inhibitor Yes MSN05 Down Microtubule crosslinking and bundling 0.010075061 11.5 NaN MAP2;MTCL1
pazopanib Kinase inhibitor Yes MSN06 Down Microtubule crosslinking and bundling 0.005875567 3 NaN MAP2;MTCL1
pazopanib Kinase inhibitor Yes MSN08 Down Microtubule polymerization 0.007013957 4 NaN DCLK1;TUBA1A
pazopanib Kinase inhibitor Yes MSN09 Down Microtubule polymerization 0.009570814 4.5 NaN DCLK1;TUBA1A
pazopanib Kinase inhibitor Yes MSN01 Up Mitochondrial ADP import and ATP export 0.023641496 18.5 NaN SLC25A5
pazopanib Kinase inhibitor Yes MSN05 Up Mitochondrial ADP import and ATP export 0.01614326 9 NaN SLC25A5
pazopanib Kinase inhibitor Yes MSN06 Up Mitochondrial ADP import and ATP export 0.021347918 13 NaN SLC25A5
pazopanib Kinase inhibitor Yes MSN08 Up Mitochondrial ADP import and ATP export 0.021083275 11.5 NaN SLC25A5
pazopanib Kinase inhibitor Yes MSN01 Up Mitochondrial fusion 0.017964125 14 NaN MFN2;PHB
olmesartan Antihypertensive No MSN08 Down Eukaryotic kinetochore dynamics 0.002283887 3 NaN BUB1;CENPE;CENPF;MAD2L1;TTK
olmesartan Antihypertensive No MSN06 Up Extracellular matrix breakdown and membrane shedding by adamalysins 0.014277759 8 NaN ADAM33;ADAMTS15;ADAMTS2
olmesartan Antihypertensive No MSN09 Up Extracellular matrix breakdown and membrane shedding by adamalysins 0.017257201 10 NaN ADAM33;ADAMTS15;ADAMTS2
olmesartan Antihypertensive No MSN01 Down Extracellular matrix breakdown and membrane shedding by adamalysins 0.013507381 6 NaN ADAM12;ADAMTS14;ADAMTS7
olmesartan Antihypertensive No MSN06 Down Extracellular matrix breakdown and membrane shedding by adamalysins 0.002029311 3 NaN ADAMTS14;ADAMTS17;ADAMTS4;ADAMTS8
olmesartan Antihypertensive No MSN09 Down Extracellular matrix breakdown and membrane shedding by adamalysins 0.014751879 9 NaN ADAM12;ADAMTS14;ADAMTS8
olmesartan Antihypertensive No MSN05 Down Extracellular matrix breakdown by matrix metalloproteases 0.017964125 11 NaN MMP1;MMP12
olmesartan Antihypertensive No MSN01 Up Extracellular matrix breakdown by serine proteases 0.009601976 7 NaN KLK5;PRSS12
olmesartan Antihypertensive No MSN01 Up Fibrillar collagen core structure organization 0.019690847 9 NaN COL1A2;COL3A1
olmesartan Antihypertensive No MSN01 Down Fibrillar collagen core structure organization 0.000995243 2 NaN COL11A1;COL2A1;COL5A3
olmesartan Antihypertensive No MSN05 Down Fibrillar collagen core structure organization 0.001386247 2.5 NaN COL11A1;COL1A1;COL1A2
olmesartan Antihypertensive No MSN06 Down Fibrillar collagen core structure organization 0.00128425 1.5 NaN COL11A1;COL2A1;COL5A2
olmesartan Antihypertensive No MSN09 Down Fibrillar collagen core structure organization 1.09E-06 1 NaN COL11A1;COL1A1;COL2A1;COL5A2;COL5A3
olmesartan Antihypertensive No MSN06 Up Fibroblast growth factor receptor signaling 0.026417399 13 NaN FGF1;FGF18
olmesartan Antihypertensive No MSN09 Up Fibroblast growth factor receptor signaling 0.030147281 14 NaN FGF1;FGF18
olmesartan Antihypertensive No MSN08 Down Fibronectin synthesis and extracellular assembly 0.005786869 8 NaN FN1;ITGA5
olmesartan Antihypertensive No MSN01 Up Fibulin receptor signaling 0.043967869 11 NaN FBLN1
olmesartan Antihypertensive No MSN06 Up Fibulin receptor signaling 0.042587255 15.5 NaN FBLN1
olmesartan Antihypertensive No MSN08 Up Fibulin receptor signaling 0.038266416 13.5 NaN FBLN1
olmesartan Antihypertensive No MSN09 Up Fibulin receptor signaling 0.045692235 17.5 NaN FBLN1
olmesartan Antihypertensive No MSN08 Up Filopodium organization 0.010671147 7 NaN ENAH;GPM6A;TNK2
olmesartan Antihypertensive No MSN05 Down G2 M transition checkpoint 0.002453841 4 NaN CCNB1;CDC25C;CDK1
olmesartan Antihypertensive No MSN06 Down G2 M transition checkpoint 0.029934709 11 NaN CCNB1;CDK1
olmesartan Antihypertensive No MSN09 Down G2 M transition checkpoint 0.027024728 16 NaN CCNB1;CDK1
olmesartan Antihypertensive No MSN05 Up Glutamate and glutamine metabolism 0.03055135 10.5 NaN SLC38A2;SLC7A5
olmesartan Antihypertensive No MSN08 Up Glutamate and glutamine metabolism 0.025189984 11 NaN SLC38A2;SLC7A5
olmesartan Antihypertensive No MSN08 Down Glutamate and glutamine metabolism 0.003548064 5 NaN GLS2;SLC1A3;SLC1A5
olmesartan Antihypertensive No MSN01 Down Glycolysis and Gluconeogenesis 6.16E-06 1 NaN ALDOA;ENO1;LDHA;PCK2;PGK1;TPI1
olmesartan Antihypertensive No MSN06 Down Glycolysis and Gluconeogenesis 0.015201431 5 NaN ENO1;LDHA;PFKFB3
olmesartan Antihypertensive No MSN09 Down Glycolysis and Gluconeogenesis 0.01311516 8 NaN ENO1;LDHA;PFKFB3
olmesartan Antihypertensive No MSN01 Down Granulocyte macrophage colony-stimulating factor receptor signaling 0.041723865 13.5 NaN JUND
olmesartan Antihypertensive No MSN05 Down Granulocyte macrophage colony-stimulating factor receptor signaling 0.046726108 20 NaN JUND
olmesartan Antihypertensive No MSN06 Down Granulocyte macrophage colony-stimulating factor receptor signaling 0.045519869 15 NaN JUND
olmesartan Antihypertensive No MSN08 Down Granulocyte macrophage colony-stimulating factor receptor signaling 0.048792173 18 NaN JUND
olmesartan Antihypertensive No MSN09 Down Granulocyte macrophage colony-stimulating factor receptor signaling 0.043105102 20 NaN JUND
olmesartan Antihypertensive No MSN05 Up Growth differentiation factor receptor signaling 0.011766804 5 NaN GDF11;GDF6
olmesartan Antihypertensive No MSN08 Up Growth differentiation factor receptor signaling 0.009634616 6 NaN GDF2;GDF6
olmesartan Antihypertensive No MSN01 Down Hepatocyte growth factor receptor signaling 0.041723865 13.5 NaN HGF
olmesartan Antihypertensive No MSN08 Down Hepatocyte growth factor receptor signaling 0.048792173 18 NaN HGF
olmesartan Antihypertensive No MSN05 Up Inhibition of amyloid aggregation, amyloid degradation and uptake 0.001353509 2 NaN A2M;PLAT
olmesartan Antihypertensive No MSN06 Up Inhibition of amyloid aggregation, amyloid degradation and uptake 0.001364613 1 NaN A2M;PLAT
olmesartan Antihypertensive No MSN08 Up Inhibition of amyloid aggregation, amyloid degradation and uptake 0.001100428 2 NaN A2M;PLAT
olmesartan Antihypertensive No MSN09 Up Inhibition of amyloid aggregation, amyloid degradation and uptake 0.001572131 2 NaN A2M;PLAT
olmesartan Antihypertensive No MSN01 Up Inositol metabolism and transport 0.043967869 11 NaN INPP5D
olmesartan Antihypertensive No MSN06 Up JAK-STAT signaling pathway 0.035413375 14 NaN SOCS3;STAT4
olmesartan Antihypertensive No MSN05 Up Ketone body metabolism 0.021436133 7.5 NaN OXCT1
olmesartan Antihypertensive No MSN06 Up Ketone body metabolism 0.021524347 10 NaN OXCT1
olmesartan Antihypertensive No MSN09 Up Ketone body metabolism 0.023112209 11.5 NaN OXCT1
olmesartan Antihypertensive No MSN08 Up Lamellipodium organization 0.01967162 10 NaN ARAP3;ENAH;TIAM2
olmesartan Antihypertensive No MSN06 Up Lipogenesis 0.042587255 15.5 NaN FASN
olmesartan Antihypertensive No MSN09 Up Lipogenesis 0.045692235 17.5 NaN FASN
olmesartan Antihypertensive No MSN01 Down Macrophage migration inhibitory factor signaling 0.004244577 3 NaN CXCR4;JUND
olmesartan Antihypertensive No MSN05 Down Macrophage migration inhibitory factor signaling 0.005312003 6 NaN CXCR4;JUND
olmesartan Antihypertensive No MSN09 Down Macrophage migration inhibitory factor signaling 0.004527641 3.5 NaN CXCR4;JUND
olmesartan Antihypertensive No MSN05 Down Metaphase to anaphase checkpoint 0.045631721 17 NaN BUB1;PTTG1;TTK
olmesartan Antihypertensive No MSN08 Down Metaphase to anaphase checkpoint 0.001371996 1 NaN BUB1;CENPE;MAD2L1;PTTG1;TTK
olmesartan Antihypertensive No MSN05 Down Mitotic spindle assembly 7.84E-06 1 NaN DLGAP5;NUSAP1;TACC3;TPX2;TTK
olmesartan Antihypertensive No MSN06 Down Mitotic spindle assembly 0.034848653 12.5 NaN DLGAP5;TPX2
olmesartan Antihypertensive No MSN08 Down Mitotic spindle assembly 0.003548064 5 NaN DLGAP5;TPX2;TTK
olmesartan Antihypertensive No MSN09 Down Mitotic spindle assembly 0.031486283 17.5 NaN DLGAP5;TPX2
olmesartan Antihypertensive No MSN05 Down Mitotic spindle disassembly 0.023641496 13.5 NaN CDK1
olmesartan Antihypertensive No MSN06 Down Mitotic spindle disassembly 0.023023994 7.5 NaN CDK1
olmesartan Antihypertensive No MSN08 Down Mitotic spindle disassembly 0.024700071 14 NaN CDK1
olmesartan Antihypertensive No MSN09 Down Mitotic spindle disassembly 0.021788991 12.5 NaN CDK1
olmesartan Antihypertensive No MSN01 Up Natriuretic peptide receptor signaling 0.006960163 4.5 NaN NPPA;NPPB
olmesartan Antihypertensive No MSN05 Down Natriuretic peptide receptor signaling 0.007844056 8 NaN NPPA;NPPB
olmesartan Antihypertensive No MSN06 Down Natriuretic peptide receptor signaling 0.007451277 4 NaN NPPA;NPPB
olmesartan Antihypertensive No MSN09 Down Natriuretic peptide receptor signaling 0.006694109 5.5 NaN NPPA;NPPB
olmesartan Antihypertensive No MSN05 Down Nodal growth differentiation factor receptor signaling 0.042024881 16 NaN DACT2;LEFTY2
olmesartan Antihypertensive No MSN09 Up Osteopontin receptor signaling 0.023112209 11.5 NaN SPP1
olmesartan Antihypertensive No MSN01 Up Platelet-derived growth factor receptor signaling 0.00156935 3 NaN FOSL1;PDGFRB;RGS5
olmesartan Antihypertensive No MSN05 Up Platelet-derived growth factor receptor signaling 0.022155988 9 NaN PDGFRB;RGS5
olmesartan Antihypertensive No MSN06 Up Platelet-derived growth factor receptor signaling 0.022327276 12 NaN PDGFRB;RGS5
olmesartan Antihypertensive No MSN08 Up Platelet-derived growth factor receptor signaling 0.001046445 1 NaN PDGFRB;RGS5;TNK2
olmesartan Antihypertensive No MSN09 Up Platelet-derived growth factor receptor signaling 0.02550613 13 NaN PDGFRB;RGS5
olmesartan Antihypertensive No MSN05 Down Progesterone receptor signaling 0.023641496 13.5 NaN PGR
olmesartan Antihypertensive No MSN06 Down Progesterone receptor signaling 0.023023994 7.5 NaN PGR
olmesartan Antihypertensive No MSN08 Down Progesterone receptor signaling 0.024700071 14 NaN PGR
olmesartan Antihypertensive No MSN06 Up Prostaglandin E2 receptor signaling 0.006536814 3 NaN PTGER2;PTGER3
olmesartan Antihypertensive No MSN09 Up Prostaglandin E2 receptor signaling 0.007506811 3.5 NaN PTGER2;PTGER3
olmesartan Antihypertensive No MSN05 Down Prostaglandin PGF2 alpha receptor signaling 0.046726108 20 NaN PTGFR
olmesartan Antihypertensive No MSN06 Down Prostaglandin PGF2 alpha receptor signaling 0.045519869 15 NaN PTGFR
olmesartan Antihypertensive No MSN08 Down Prostaglandin PGF2 alpha receptor signaling 0.048792173 18 NaN PTGFR
olmesartan Antihypertensive No MSN09 Down Prostaglandin PGF2 alpha receptor signaling 0.043105102 20 NaN PTGFR
olmesartan Antihypertensive No MSN01 Up Proteasomal regulatory particle organization 0.009601976 7 NaN PSMC4;PSMD14
olmesartan Antihypertensive No MSN06 Up Proteasomal regulatory particle organization 0.009022183 5 NaN PSMC4;PSMD14
olmesartan Antihypertensive No MSN09 Up Proteasomal regulatory particle organization 0.010350023 6.5 NaN PSMC4;PSMD14
olmesartan Antihypertensive No MSN01 Down Retinol metabolism 0.029628054 11 NaN ALDH1A1;RDH10
olmesartan Antihypertensive No MSN05 Down Retinol metabolism 0.003134623 5 NaN ALDH1A2;ALDH1A3;TTR
olmesartan Antihypertensive No MSN06 Down Retinol metabolism 0.034848653 12.5 NaN STRA6;TTR
olmesartan Antihypertensive No MSN08 Down Retinol metabolism 0.003548064 5 NaN ALDH1A1;ALDH1A2;TTR
olmesartan Antihypertensive No MSN09 Down Retinol metabolism 0.031486283 17.5 NaN STRA6;TTR
olmesartan Antihypertensive No MSN05 Up Roundabout signaling 0.008950881 4 NaN ROBO1;ROBO2
olmesartan Antihypertensive No MSN06 Up Roundabout signaling 0.009022183 5 NaN ROBO1;ROBO2
olmesartan Antihypertensive No MSN08 Up Roundabout signaling 0.007318648 5 NaN ROBO1;ROBO2
olmesartan Antihypertensive No MSN09 Up Roundabout signaling 0.010350023 6.5 NaN ROBO1;ROBO2
olmesartan Antihypertensive No MSN05 Up Semaphorin signaling 0.005764974 3 NaN DPYSL4;NRP2;PLXNA2;SEMA3A
olmesartan Antihypertensive No MSN09 Up Semaphorin signaling 0.043141308 16 NaN DPYSL4;PLXNA2;SEMA3F
olmesartan Antihypertensive No MSN01 Down Serine and glycine metabolism 0.02147651 10 NaN PHGDH;SHMT2
olmesartan Antihypertensive No MSN08 Down Serine and glycine metabolism 0.028862138 16 NaN PHGDH;SLC1A5
olmesartan Antihypertensive No MSN09 Down Serine and glycine metabolism 0.022844529 15 NaN PHGDH;SHMT2
olmesartan Antihypertensive No MSN01 Down Serotonin inactivation 0.041723865 13.5 NaN MAOA
olmesartan Antihypertensive No MSN05 Down Serotonin inactivation 0.046726108 20 NaN MAOA
olmesartan Antihypertensive No MSN06 Down Serotonin inactivation 0.045519869 15 NaN MAOA
olmesartan Antihypertensive No MSN09 Down Serotonin inactivation 0.043105102 20 NaN MAOA
olmesartan Antihypertensive No MSN05 Down Sister chromatid attachment to mitotic spindle 0.046726108 20 NaN TACC3
olmesartan Antihypertensive No MSN05 Down Sister chromatid segregation 0.007844056 8 NaN PTTG1;TOP2A
olmesartan Antihypertensive No MSN08 Down Sister chromatid segregation 0.008539224 10 NaN PTTG1;TOP2A
olmesartan Antihypertensive No MSN09 Down Sister chromatid segregation 0.006694109 5.5 NaN PTTG1;TOP2A
olmesartan Antihypertensive No MSN01 Up Thin myofilament organization 0.009601976 7 NaN ACTA1;LMOD3
olmesartan Antihypertensive No MSN05 Down Thin myofilament organization 0.010811186 10 NaN TNNI3;TPM1
olmesartan Antihypertensive No MSN01 Down Tropoelastin synthesis 0.021083275 8 NaN ELN
olmesartan Antihypertensive No MSN05 Down Tropoelastin synthesis 0.023641496 13.5 NaN ELN
olmesartan Antihypertensive No MSN06 Down Tropoelastin synthesis 0.023023994 7.5 NaN ELN
olmesartan Antihypertensive No MSN08 Down Tropoelastin synthesis 0.024700071 14 NaN ELN
olmesartan Antihypertensive No MSN09 Down Tropoelastin synthesis 0.021788991 12.5 NaN ELN
olmesartan Antihypertensive No MSN08 Up Versican receptor signaling 0.038266416 13.5 NaN VCAN
olmesartan Antihypertensive No MSN01 Down Versican receptor signaling 0.041723865 13.5 NaN VCAN
olmesartan Antihypertensive No MSN08 Up Versican synthesis 0.019318984 8.5 NaN VCAN
olmesartan Antihypertensive No MSN01 Down Versican synthesis 0.021083275 8 NaN VCAN
olmesartan Antihypertensive No MSN05 Up WNT-Beta-catenin signaling pathway 0.048181864 12 NaN APCDD1;PAX6;SFRP2;SFRP5
olmesartan Antihypertensive No MSN08 Up WNT-Beta-catenin signaling pathway 0.034993337 12 NaN LRP4;PAX6;SFRP2;SFRP5
olmesartan Antihypertensive No MSN01 Up Z-disc organization 0.048125749 13 NaN BAG3;LDB3
olmesartan Antihypertensive No MSN09 Down Z-disc organization 0.046420056 22 NaN DES;PDLIM3
olmesartan Antihypertensive No MSN08 Up Actin polymerization 0.047049834 15 NaN ABRA;ACTA1;ENAH
olmesartan Antihypertensive No MSN05 Up Adrenergic receptor signaling 0.01758165 6 NaN ADCY2;GPR3;RAPGEF4
olmesartan Antihypertensive No MSN06 Up Albumin mediated blood protein transport 0.021524347 10 NaN ALB
olmesartan Antihypertensive No MSN09 Down Albumin mediated blood protein transport 0.021788991 12.5 NaN ALB
olmesartan Antihypertensive No MSN06 Down Amyloid plaque organization 0.025324824 10 NaN COL25A1;VSNL1
olmesartan Antihypertensive No MSN08 Down Basement membrane assembly and organization 0.024000534 11.5 NaN COL4A3;COL4A4
olmesartan Antihypertensive No MSN01 Down Biglycan synthesis 0.021083275 8 NaN BGN
olmesartan Antihypertensive No MSN05 Down Biglycan synthesis 0.023641496 13.5 NaN BGN
olmesartan Antihypertensive No MSN06 Down Biglycan synthesis 0.023023994 7.5 NaN BGN
olmesartan Antihypertensive No MSN09 Down Biglycan synthesis 0.021788991 12.5 NaN BGN
olmesartan Antihypertensive No MSN01 Down Cardiomyocyte pacemaker current generation 0.011397983 4.5 NaN CACNA1G;HCN4
olmesartan Antihypertensive No MSN01 Up CD44-Mediated leukocyte rolling 0.043967869 11 NaN CD44
olmesartan Antihypertensive No MSN05 Down CD44-Mediated leukocyte rolling 0.046726108 20 NaN CD44
olmesartan Antihypertensive No MSN05 Up Cellular cholesterol uptake and efflux 0.03055135 10.5 NaN ABCA7;ABCG1
olmesartan Antihypertensive No MSN06 Up Cellular cholesterol uptake and efflux 0.002401113 2 NaN ABCA7;ABCG1;ARL4C
olmesartan Antihypertensive No MSN08 Up Cellular cholesterol uptake and efflux 0.001762747 3 NaN ABCA1;ABCA7;ABCG1
olmesartan Antihypertensive No MSN09 Up Cellular cholesterol uptake and efflux 0.035094106 15 NaN ABCA7;ARL4C
olmesartan Antihypertensive No MSN05 Down Centrosome separation 0.001386247 2.5 NaN CCNB1;CDK1;KIF11
olmesartan Antihypertensive No MSN06 Down Centrosome separation 0.00128425 1.5 NaN CCNB1;CDK1;KIF11
olmesartan Antihypertensive No MSN08 Down Centrosome separation 0.024000534 11.5 NaN CDK1;KIF11
olmesartan Antihypertensive No MSN09 Down Centrosome separation 0.018960318 10 NaN CCNB1;CDK1
olmesartan Antihypertensive No MSN01 Up Cholesterol synthesis 3.39E-06 1 NaN CYP51A1;HMGCR;HMGCS1;MSMO1;SC5D;SQLE
olmesartan Antihypertensive No MSN09 Up Cholesterol synthesis 0.00100893 1 NaN DHCR7;HMGCR;MSMO1;SQLE
olmesartan Antihypertensive No MSN09 Up Cholesterol-sensitive control of SREBP activation 0.007506811 3.5 NaN INSIG1;SREBF1
olmesartan Antihypertensive No MSN01 Up Classical complement pathway 0.000355631 2 NaN C1QB;C1QC;C1R
olmesartan Antihypertensive No MSN09 Up Classical complement pathway 0.010350023 6.5 NaN C1QB;C1R
olmesartan Antihypertensive No MSN08 Down Collagen fiber crosslinking 0.005786869 8 NaN LOX;LOXL1
olmesartan Antihypertensive No MSN09 Down Collagen fiber crosslinking 0.004527641 3.5 NaN LOX;LOXL1
olmesartan Antihypertensive No MSN01 Up Collagen fibril organization by fibril-associated bridges 0.006960163 4.5 NaN COL14A1;COL9A3
olmesartan Antihypertensive No MSN05 Up Collagen fibril organization by fibril-associated bridges 0.000185509 1 NaN COL12A1;COL9A2;COL9A3
olmesartan Antihypertensive No MSN08 Up Collagen fibril organization by fibril-associated bridges 0.005294767 4 NaN COL9A2;COL9A3
olmesartan Antihypertensive No MSN05 Down Collagen fibril organization by fibril-associated bridges 0.007844056 8 NaN COL14A1;COL9A1
olmesartan Antihypertensive No MSN08 Down Contractile ring constriction 0.005786869 8 NaN ANLN;MYLK
olmesartan Antihypertensive No MSN05 Up Decorin synthesis 0.021436133 7.5 NaN DCN
olmesartan Antihypertensive No MSN06 Up Decorin synthesis 0.021524347 10 NaN DCN
olmesartan Antihypertensive No MSN08 Up Decorin synthesis 0.019318984 8.5 NaN DCN
olmesartan Antihypertensive No MSN06 Up Desaturation of fatty acids 0.009022183 5 NaN FADS2;SCD
olmesartan Antihypertensive No MSN09 Up Desaturation of fatty acids 0.010350023 6.5 NaN FADS2;SCD
olmesartan Antihypertensive No MSN08 Down Elastin cross-linking and assembly 0.00179408 2 NaN LOX;LOXL1
olmesartan Antihypertensive No MSN09 Down Elastin cross-linking and assembly 0.001398195 2 NaN LOX;LOXL1
olmesartan Antihypertensive No MSN06 Up Epithelial intermediate filament dynamics 0.011859842 7 NaN KRT4;TCHH
olmesartan Antihypertensive No MSN09 Up Epithelial intermediate filament dynamics 0.013590977 9 NaN KRT4;TCHH
olmesartan Antihypertensive No MSN01 Down Epithelial intermediate filament dynamics 0.011397983 4.5 NaN KRT19;KRT8
olmesartan Antihypertensive No MSN09 Down Epithelial intermediate filament dynamics 0.012140948 7 NaN KRT19;KRT8
nilotinib Kinase inhibitor No MSN05 Down Actin polymerization 0.031680878 12 NaN ABRA;ACTA1;ENAH
nilotinib Kinase inhibitor No MSN01 Up Adrenergic receptor signaling 0.033631608 27 NaN GRK5;RGS16;RGS4
nilotinib Kinase inhibitor No MSN05 Down Albumin mediated blood protein transport 0.016496119 8 NaN ALB
nilotinib Kinase inhibitor No MSN06 Down Albumin mediated blood protein transport 0.020201129 10 NaN ALB
nilotinib Kinase inhibitor No MSN08 Down Albumin mediated blood protein transport 0.018877911 11.5 NaN ALB
nilotinib Kinase inhibitor No MSN09 Down Albumin mediated blood protein transport 0.021083275 10 NaN ALB
nilotinib Kinase inhibitor No MSN01 Up Antigen presentation via MHC class I molecules 0.029364515 26 NaN B2M;HLA-C
nilotinib Kinase inhibitor No MSN05 Up Aspartate and arginine metabolism 0.032033347 25 NaN ARG2;SLC7A1
nilotinib Kinase inhibitor No MSN06 Up Aspartate and arginine metabolism 0.02729964 27 NaN ARG2;SLC7A1
nilotinib Kinase inhibitor No MSN09 Up Aspartate and arginine metabolism 0.024808376 24 NaN ARG2;SLC7A1
nilotinib Kinase inhibitor No MSN05 Up Biglycan synthesis 0.028846154 23 NaN BGN
nilotinib Kinase inhibitor No MSN08 Up Biglycan synthesis 0.027258292 29.5 NaN BGN
nilotinib Kinase inhibitor No MSN06 Down Cardiomyocyte pacemaker current generation 0.010499387 6.5 NaN CACNA1G;TRPM4
nilotinib Kinase inhibitor No MSN08 Down Cardiomyocyte pacemaker current generation 0.009215038 8 NaN CACNA1G;TRPM4
nilotinib Kinase inhibitor No MSN09 Down Cardiomyocyte pacemaker current generation 0.011397983 4.5 NaN CACNA1G;TRPM4
nilotinib Kinase inhibitor No MSN05 Down Cardiomyocyte repolarization during action potential and hyperpolarization 0.021622693 11 NaN KCNIP2;KCNQ5
nilotinib Kinase inhibitor No MSN08 Down CCN intercellular signaling protein family receptor signaling 0.003416552 5 NaN CYR61;WISP1
nilotinib Kinase inhibitor No MSN01 Down CD44-Mediated leukocyte rolling 0.039477231 12.5 NaN CD44
nilotinib Kinase inhibitor No MSN06 Down CD44-Mediated leukocyte rolling 0.039995919 13 NaN CD44
nilotinib Kinase inhibitor No MSN08 Down CD44-Mediated leukocyte rolling 0.037401081 14.5 NaN CD44
nilotinib Kinase inhibitor No MSN09 Down CD44-Mediated leukocyte rolling 0.041723865 13 NaN CD44
nilotinib Kinase inhibitor No MSN08 Up Cell cycle arrest in response to DNA damage 0.026579947 27 NaN CDKN1A;GADD45A;H2AFX
nilotinib Kinase inhibitor No MSN08 Up Centrosome duplication 0.004355947 16 NaN CDKN1A;GADD45A;PLK2;PLK4
nilotinib Kinase inhibitor No MSN01 Up Centrosome maturation 0.003776716 11 NaN AURKA;PLK1;TPX2
nilotinib Kinase inhibitor No MSN05 Up Centrosome maturation 0.004310912 14 NaN AURKA;PLK1;TPX2
nilotinib Kinase inhibitor No MSN06 Up Centrosome maturation 0.003380484 14.5 NaN AURKA;PLK1;TPX2
nilotinib Kinase inhibitor No MSN08 Up Centrosome maturation 0.003675094 12.5 NaN AURKA;PLK1;TPX2
nilotinib Kinase inhibitor No MSN09 Up Centrosome maturation 0.002923036 13.5 NaN AURKA;PLK1;TPX2
nilotinib Kinase inhibitor No MSN01 Up Centrosome organization 0.010849095 17 NaN ASPM;ATF5;GRK5;NEK2;TACC3;WDR62
nilotinib Kinase inhibitor No MSN05 Up Centrosome organization 0.046142207 29 NaN ASPM;ATF5;NEK2;TACC3;WDR62
nilotinib Kinase inhibitor No MSN06 Up Centrosome organization 0.002064787 13 NaN ASPM;ATF5;NEK2;PLK4;POC1A;TACC3;WDR62
nilotinib Kinase inhibitor No MSN08 Up Centrosome organization 0.002439115 11 NaN ASPM;ATF5;NEK2;PLK4;POC1A;TACC3;WDR62
nilotinib Kinase inhibitor No MSN09 Up Centrosome organization 0.007112445 17 NaN ASPM;ATF5;NEK2;POC1A;TACC3;WDR62
nilotinib Kinase inhibitor No MSN01 Up Centrosome separation 1.25E-09 1 NaN AURKA;CCNB1;CDK1;ESPL1;KIF11;NEK2;SPAG5
nilotinib Kinase inhibitor No MSN05 Up Centrosome separation 1.89E-11 1 NaN AURKA;CCNB1;CDK1;ESPL1;KIF11;NEK2;NEK6;SPAG5
nilotinib Kinase inhibitor No MSN06 Up Centrosome separation 9.43E-12 1 NaN AURKA;CCNB1;CDK1;ESPL1;KIF11;NEK2;NEK6;SPAG5
nilotinib Kinase inhibitor No MSN08 Up Centrosome separation 1.20E-11 1 NaN AURKA;CCNB1;CDK1;ESPL1;KIF11;NEK2;NEK6;SPAG5
nilotinib Kinase inhibitor No MSN09 Up Centrosome separation 6.24E-12 1 NaN AURKA;CCNB1;CDK1;ESPL1;KIF11;NEK2;NEK6;SPAG5
nilotinib Kinase inhibitor No MSN05 Up Cholesterol synthesis 1.52E-05 5 NaN DHCR24;DHCR7;FDPS;MVD;MVK;SQLE
nilotinib Kinase inhibitor No MSN01 Up Cholesterol-sensitive control of SREBP activation 0.010526062 15 NaN INSIG1;SREBF1
nilotinib Kinase inhibitor No MSN05 Up Cholesterol-sensitive control of SREBP activation 0.011523002 17.5 NaN INSIG1;SREBF1
nilotinib Kinase inhibitor No MSN09 Up Classical complement pathway 0.012167509 21.5 NaN C1R;C1S
nilotinib Kinase inhibitor No MSN01 Up Collagen fibril organization by fibril-associated bridges 0.010526062 15 NaN COL9A1;COL9A3
nilotinib Kinase inhibitor No MSN05 Down Collagen fibril organization by fibril-associated bridges 8.52E-05 2 NaN COL12A1;COL9A2;COL9A3
nilotinib Kinase inhibitor No MSN06 Down Collagen fibril organization by fibril-associated bridges 0.005776787 5 NaN COL12A1;COL9A3
nilotinib Kinase inhibitor No MSN01 Up Contractile ring constriction 0.007146805 13 NaN ANLN;ECT2
nilotinib Kinase inhibitor No MSN05 Up Contractile ring constriction 3.32E-06 2 NaN ANLN;ECT2;MYH14;MYLK
nilotinib Kinase inhibitor No MSN06 Up Contractile ring constriction 0.000176406 6.5 NaN ANLN;ECT2;MYLK
nilotinib Kinase inhibitor No MSN08 Up Contractile ring constriction 0.007013572 18 NaN ANLN;ECT2
nilotinib Kinase inhibitor No MSN09 Up Contractile ring constriction 0.000151472 6.5 NaN ANLN;ECT2;MYLK
nilotinib Kinase inhibitor No MSN05 Up Contractile ring formation 0.007830627 16 NaN MYH14;RACGAP1
nilotinib Kinase inhibitor No MSN01 Up Decorin synthesis 0.027522936 23.5 NaN DCN
nilotinib Kinase inhibitor No MSN05 Down Decorin synthesis 0.016496119 8 NaN DCN
nilotinib Kinase inhibitor No MSN06 Down Decorin synthesis 0.020201129 10 NaN DCN
nilotinib Kinase inhibitor No MSN09 Down Decorin synthesis 0.021083275 10 NaN DCN
nilotinib Kinase inhibitor No MSN05 Up Desaturation of fatty acids 0.015826754 19.5 NaN FADS2;SCD
nilotinib Kinase inhibitor No MSN06 Up Desaturation of fatty acids 0.013424521 21 NaN FADS2;SCD
nilotinib Kinase inhibitor No MSN08 Up Desaturation of fatty acids 0.014205479 23.5 NaN FADS2;SCD
nilotinib Kinase inhibitor No MSN09 Up Desaturation of fatty acids 0.012167509 21.5 NaN FADS2;SCD
nilotinib Kinase inhibitor No MSN01 Down Drug and toxin export via membrane transport proteins 0.049098649 14 NaN ABCA1;ABCC3
nilotinib Kinase inhibitor No MSN06 Up Epithelial intermediate filament dynamics 0.017589037 22.5 NaN KRT4;TCHH
nilotinib Kinase inhibitor No MSN05 Down Epithelial intermediate filament dynamics 0.007099288 5 NaN KRT19;KRT7
nilotinib Kinase inhibitor No MSN06 Down Epithelial intermediate filament dynamics 0.010499387 6.5 NaN KRT19;KRT7
nilotinib Kinase inhibitor No MSN09 Down Epithelial intermediate filament dynamics 0.011397983 4.5 NaN KRT19;KRT7
nilotinib Kinase inhibitor No MSN01 Up Equatorial RhoA activation 0.004367359 12 NaN ECT2;KIF23
nilotinib Kinase inhibitor No MSN05 Up Equatorial RhoA activation 0.0047895 15 NaN ECT2;KIF23
nilotinib Kinase inhibitor No MSN06 Up Equatorial RhoA activation 0.004043143 16.5 NaN ECT2;KIF23
nilotinib Kinase inhibitor No MSN08 Up Equatorial RhoA activation 0.004285177 14.5 NaN ECT2;KIF23
nilotinib Kinase inhibitor No MSN09 Up Equatorial RhoA activation 0.003654836 15.5 NaN ECT2;KIF23
nilotinib Kinase inhibitor No MSN01 Up ER unfolded protein response pathway 0.01894582 20.5 NaN ATF4;DDIT3
nilotinib Kinase inhibitor No MSN05 Up ER unfolded protein response pathway 0.001195745 12 NaN ATF4;DDIT3;HERPUD1
nilotinib Kinase inhibitor No MSN06 Up ER unfolded protein response pathway 0.000930974 11 NaN ATF4;DDIT3;HERPUD1
nilotinib Kinase inhibitor No MSN08 Up ER unfolded protein response pathway 0.001014528 9 NaN ATF4;DDIT3;HERPUD1
nilotinib Kinase inhibitor No MSN09 Up ER unfolded protein response pathway 0.000801798 11 NaN ATF4;DDIT3;HERPUD1
nilotinib Kinase inhibitor No MSN01 Up Mitotic spindle disassembly 0.027522936 23.5 NaN CDK1
nilotinib Kinase inhibitor No MSN05 Up Mitotic spindle disassembly 0.028846154 23 NaN CDK1
nilotinib Kinase inhibitor No MSN06 Up Mitotic spindle disassembly 0.026464361 25 NaN CDK1
nilotinib Kinase inhibitor No MSN08 Up Mitotic spindle disassembly 0.027258292 29.5 NaN CDK1
nilotinib Kinase inhibitor No MSN09 Up Mitotic spindle disassembly 0.025141143 26 NaN CDK1
nilotinib Kinase inhibitor No MSN01 Down Muscarinic receptor signaling 0.0056301 4 NaN CHRM4;RGS5
nilotinib Kinase inhibitor No MSN06 Down Myofibril formation 0.016431153 8 NaN DES;KLHL41
nilotinib Kinase inhibitor No MSN01 Up Natriuretic peptide receptor signaling 0.010526062 15 NaN NPPA;NPPB
nilotinib Kinase inhibitor No MSN06 Up Nuclear envelope maintenance 0.009758505 19.5 NaN LMNB1;TMPO
nilotinib Kinase inhibitor No MSN08 Up Nuclear envelope maintenance 0.010331661 21 NaN LMNB1;TMPO
nilotinib Kinase inhibitor No MSN09 Up Nuclear envelope maintenance 0.008836966 19 NaN LMNB1;TMPO
nilotinib Kinase inhibitor No MSN06 Up Nuclear intermediate filaments 0.009758505 19.5 NaN LMNB1;TMPO
nilotinib Kinase inhibitor No MSN08 Up Nuclear intermediate filaments 0.010331661 21 NaN LMNB1;TMPO
nilotinib Kinase inhibitor No MSN09 Up Nuclear intermediate filaments 0.008836966 19 NaN LMNB1;TMPO
nilotinib Kinase inhibitor No MSN01 Down Osteonectin receptor signaling 0.00231233 2.5 NaN SPARC;SPOCK1
nilotinib Kinase inhibitor No MSN05 Down Osteopontin receptor signaling 0.016496119 8 NaN SPP1
nilotinib Kinase inhibitor No MSN06 Down Osteopontin receptor signaling 0.020201129 10 NaN SPP1
nilotinib Kinase inhibitor No MSN08 Down Osteopontin receptor signaling 0.018877911 11.5 NaN SPP1
nilotinib Kinase inhibitor No MSN05 Up Platelet-derived growth factor receptor signaling 0.038417822 26 NaN PDGFB;TNK2
nilotinib Kinase inhibitor No MSN08 Down Potassium transmembrane transport 0.010022636 9 NaN ABCC9;ATP1A2;FXYD1
nilotinib Kinase inhibitor No MSN09 Down Potassium transmembrane transport 0.013507381 6.5 NaN ABCC9;ATP1A2;FXYD1
nilotinib Kinase inhibitor No MSN05 Down Progesterone receptor signaling 0.016496119 8 NaN PGR
nilotinib Kinase inhibitor No MSN09 Down Progesterone receptor signaling 0.021083275 10 NaN PGR
nilotinib Kinase inhibitor No MSN05 Up Protein polyubiquitination 0.000939844 11 NaN ISG15;UBC;UBE2S;UCHL1
nilotinib Kinase inhibitor No MSN08 Up Protein polyubiquitination 0.008629766 19 NaN ISG15;UBC;UBE2S
nilotinib Kinase inhibitor No MSN08 Up Pyrimidine synthesis and salvage 0.018602463 25.5 NaN TK1;TYMS
nilotinib Kinase inhibitor No MSN08 Down Removal of caspase inhibition 0.037401081 14.5 NaN XAF1
nilotinib Kinase inhibitor No MSN05 Down Retinol metabolism 0.001118414 3 NaN ALDH1A1;ALDH1A3;STRA6
nilotinib Kinase inhibitor No MSN08 Down Retinol metabolism 0.001649697 4 NaN ALDH1A1;ALDH1A3;STRA6
nilotinib Kinase inhibitor No MSN01 Up Serine and glycine metabolism 0.002891019 10 NaN PHGDH;PSAT1;SHMT2
nilotinib Kinase inhibitor No MSN05 Up Serine and glycine metabolism 7.76E-06 4 NaN PHGDH;PSAT1;PSPH;SHMT2;SLC1A5
nilotinib Kinase inhibitor No MSN06 Up Serine and glycine metabolism 5.09E-06 5 NaN PHGDH;PSAT1;PSPH;SHMT2;SLC1A5
nilotinib Kinase inhibitor No MSN08 Up Serine and glycine metabolism 5.88E-06 5 NaN PHGDH;PSAT1;PSPH;SHMT2;SLC1A5
nilotinib Kinase inhibitor No MSN09 Up Serine and glycine metabolism 3.96E-06 5 NaN PHGDH;PSAT1;PSPH;SHMT2;SLC1A5
nilotinib Kinase inhibitor No MSN05 Down Serotonin and melatonin synthesis 0.048680702 16.5 NaN SLC6A4
nilotinib Kinase inhibitor No MSN01 Up Sister chromatid attachment to mitotic spindle 0.000755151 7 NaN NUF2;TACC3
nilotinib Kinase inhibitor No MSN05 Up Sister chromatid attachment to mitotic spindle 0.000829629 10 NaN NUF2;TACC3
nilotinib Kinase inhibitor No MSN06 Up Sister chromatid attachment to mitotic spindle 0.000698089 10 NaN NUF2;TACC3
nilotinib Kinase inhibitor No MSN08 Up Sister chromatid attachment to mitotic spindle 0.000740675 8 NaN NUF2;TACC3
nilotinib Kinase inhibitor No MSN09 Up Sister chromatid attachment to mitotic spindle 0.000629915 10 NaN NUF2;TACC3
nilotinib Kinase inhibitor No MSN01 Up Sister chromatid segregation 0.000388293 6 NaN ESPL1;PTTG1;TOP2A
nilotinib Kinase inhibitor No MSN05 Up Sister chromatid segregation 0.000445876 9 NaN ESPL1;PTTG1;TOP2A
nilotinib Kinase inhibitor No MSN06 Up Sister chromatid segregation 0.000345895 8 NaN ESPL1;PTTG1;TOP2A
nilotinib Kinase inhibitor No MSN08 Up Sister chromatid segregation 0.000377393 7 NaN ESPL1;PTTG1;TOP2A
nilotinib Kinase inhibitor No MSN09 Up Sister chromatid segregation 0.000297304 8 NaN ESPL1;PTTG1;TOP2A
nilotinib Kinase inhibitor No MSN06 Down Thick myofilament organization 0.001202742 4 NaN MYBPC3;MYH7
nilotinib Kinase inhibitor No MSN08 Down Thick myofilament organization 0.001050954 3 NaN MYBPC3;MYH7
nilotinib Kinase inhibitor No MSN06 Down Thin myofilament organization 0.0002682 2 NaN ACTA1;TNNI3;TPM2
nilotinib Kinase inhibitor No MSN08 Down Thin myofilament organization 0.006997877 6.5 NaN ACTA1;TPM2
nilotinib Kinase inhibitor No MSN09 Down Thin myofilament organization 0.000304244 2 NaN ACTA1;TNNI3;TPM2
nilotinib Kinase inhibitor No MSN06 Up Thrombospondin receptor signaling 0.004043143 16.5 NaN THBS1;THBS4
nilotinib Kinase inhibitor No MSN08 Up Thrombospondin receptor signaling 0.004285177 14.5 NaN THBS1;THBS4
nilotinib Kinase inhibitor No MSN09 Up Thrombospondin receptor signaling 0.003654836 15.5 NaN THBS1;THBS4
nilotinib Kinase inhibitor No MSN01 Down Thrombospondin receptor signaling 0.00231233 2.5 NaN THBS2;THBS4
nilotinib Kinase inhibitor No MSN01 Up Tropoelastin synthesis 0.027522936 23.5 NaN ELN
nilotinib Kinase inhibitor No MSN06 Up Tropoelastin synthesis 0.026464361 25 NaN ELN
nilotinib Kinase inhibitor No MSN08 Up Tropoelastin synthesis 0.027258292 29.5 NaN ELN
nilotinib Kinase inhibitor No MSN09 Up Tropoelastin synthesis 0.025141143 26 NaN ELN
nilotinib Kinase inhibitor No MSN05 Down Tropoelastin synthesis 0.016496119 8 NaN ELN
nilotinib Kinase inhibitor No MSN01 Down Vascular endothelial growth factor receptor signaling 0.007778956 6 NaN FLT1;KDR
nilotinib Kinase inhibitor No MSN08 Down Vascular endothelial growth factor receptor signaling 0.006997877 6.5 NaN FLT1;KDR
nilotinib Kinase inhibitor No MSN05 Down Vasoactive intestinal peptide receptor signaling 0.032721547 14 NaN VIPR2
nilotinib Kinase inhibitor No MSN06 Down Vasoactive intestinal peptide receptor signaling 0.039995919 13 NaN VIPR2
nilotinib Kinase inhibitor No MSN08 Down Vasoactive intestinal peptide receptor signaling 0.037401081 14.5 NaN VIPR2
nilotinib Kinase inhibitor No MSN09 Down Vasoactive intestinal peptide receptor signaling 0.041723865 13 NaN VIPR2
nilotinib Kinase inhibitor No MSN01 Up Eukaryotic kinetochore dynamics 5.15E-08 2 NaN BUB1;CENPE;CENPF;KIF15;MAD2L1;NDC80;NUF2;SPC24;TTK;ZWINT
nilotinib Kinase inhibitor No MSN05 Up Eukaryotic kinetochore dynamics 9.10E-05 7 NaN BUB1;CENPE;CENPF;NDC80;NUF2;SPC24;TTK
nilotinib Kinase inhibitor No MSN06 Up Eukaryotic kinetochore dynamics 1.39E-10 2 NaN BUB1;CENPE;CENPF;KIF15;KNSTRN;MAD2L1;NDC80;NUF2;SKA3;SPC24;TTK;ZWINT
nilotinib Kinase inhibitor No MSN08 Up Eukaryotic kinetochore dynamics 1.95E-10 2 NaN BUB1;CENPE;CENPF;KIF15;KNSTRN;MAD2L1;NDC80;NUF2;SKA3;SPC24;TTK;ZWINT
nilotinib Kinase inhibitor No MSN09 Up Eukaryotic kinetochore dynamics 1.38E-09 2 NaN BUB1;CENPE;CENPF;KIF15;KNSTRN;MAD2L1;NDC80;NUF2;SPC24;TTK;ZWINT
nilotinib Kinase inhibitor No MSN01 Down Extracellular matrix breakdown and membrane shedding by adamalysins 0.01161951 8 NaN ADAMTS1;ADAMTS5;ADAMTS6
nilotinib Kinase inhibitor No MSN08 Down Extracellular matrix breakdown and membrane shedding by adamalysins 0.000975308 2 NaN ADAM12;ADAM19;ADAMTS5;ADAMTS6
nilotinib Kinase inhibitor No MSN09 Down Extracellular matrix breakdown and membrane shedding by adamalysins 0.013507381 6.5 NaN ADAM19;ADAMTS5;ADAMTS6
nilotinib Kinase inhibitor No MSN01 Down Extracellular matrix breakdown by matrix metalloproteases 0.012989342 9 NaN MMP2;MMP3
nilotinib Kinase inhibitor No MSN01 Down Extracellular matrix breakdown by serine proteases 0.007778956 6 NaN HTRA1;PRSS12
nilotinib Kinase inhibitor No MSN01 Down Extrinsic apoptosis pathway 0.007778956 6 NaN FAS;TNFRSF10A
nilotinib Kinase inhibitor No MSN01 Up Fibrillar collagen core structure organization 0.002146032 8 NaN COL11A2;COL1A2;COL2A1
nilotinib Kinase inhibitor No MSN01 Down Fibrillar collagen core structure organization 0.016025171 10 NaN COL5A1;COL5A2
nilotinib Kinase inhibitor No MSN05 Down Fibrillar collagen core structure organization 1.39E-05 1 NaN COL11A1;COL11A2;COL1A1;COL3A1
nilotinib Kinase inhibitor No MSN06 Down Fibrillar collagen core structure organization 0.000879088 3 NaN COL11A2;COL1A1;COL2A1
nilotinib Kinase inhibitor No MSN08 Down Fibrillar collagen core structure organization 0.014446446 10 NaN COL11A1;COL2A1
nilotinib Kinase inhibitor No MSN09 Down Fibrillar collagen core structure organization 0.000995243 3 NaN COL11A2;COL1A1;COL2A1
nilotinib Kinase inhibitor No MSN01 Up G2 M transition checkpoint 0.041541674 28.5 NaN CCNB1;CDK1
nilotinib Kinase inhibitor No MSN05 Up G2 M transition checkpoint 0.045239205 27.5 NaN CCNB1;CDK1
nilotinib Kinase inhibitor No MSN06 Up G2 M transition checkpoint 0.003380484 14.5 NaN CCNB1;CDC25C;CDK1
nilotinib Kinase inhibitor No MSN08 Up G2 M transition checkpoint 0.003675094 12.5 NaN CCNB1;CDC25C;CDK1
nilotinib Kinase inhibitor No MSN09 Up G2 M transition checkpoint 0.002923036 13.5 NaN CCNB1;CDC25C;CDK1
nilotinib Kinase inhibitor No MSN05 Up GABA metabolism 0.011523002 17.5 NaN ABAT;SLC6A1
nilotinib Kinase inhibitor No MSN08 Up GABA metabolism 0.010331661 21 NaN ABAT;SLC6A1
nilotinib Kinase inhibitor No MSN09 Up GABA metabolism 0.008836966 19 NaN ABAT;SLC6A1
nilotinib Kinase inhibitor No MSN06 Up Glutamate and glutamine metabolism 0.004309257 18 NaN SLC1A5;SLC38A2;SLC7A5
nilotinib Kinase inhibitor No MSN08 Up Glutamate and glutamine metabolism 0.004682035 17 NaN SLC1A5;SLC38A2;SLC7A5
nilotinib Kinase inhibitor No MSN09 Up Glutamate and glutamine metabolism 0.040928231 29 NaN SLC1A5;SLC7A5
nilotinib Kinase inhibitor No MSN01 Up G-protein coupled receptor signaling pathway 0.016635949 19 NaN GRK5;RGS16;RGS4
nilotinib Kinase inhibitor No MSN05 Down Granulocyte macrophage colony-stimulating factor receptor signaling 0.032721547 14 NaN JAK2
nilotinib Kinase inhibitor No MSN06 Down Granulocyte macrophage colony-stimulating factor receptor signaling 0.039995919 13 NaN JAK2
nilotinib Kinase inhibitor No MSN08 Down Granulocyte macrophage colony-stimulating factor receptor signaling 0.037401081 14.5 NaN JAK2
nilotinib Kinase inhibitor No MSN09 Down Granulocyte macrophage colony-stimulating factor receptor signaling 0.041723865 13 NaN JAK2
nilotinib Kinase inhibitor No MSN01 Up Growth differentiation factor receptor signaling 0.01894582 20.5 NaN GDF15;GDF2
nilotinib Kinase inhibitor No MSN05 Up Growth differentiation factor receptor signaling 0.020703758 21 NaN GDF15;GDF2
nilotinib Kinase inhibitor No MSN06 Up Growth differentiation factor receptor signaling 0.017589037 22.5 NaN GDF15;GDF2
nilotinib Kinase inhibitor No MSN08 Up Growth differentiation factor receptor signaling 0.018602463 25.5 NaN GDF15;GDF2
nilotinib Kinase inhibitor No MSN09 Up Growth differentiation factor receptor signaling 0.01595608 23 NaN GDF15;GDF2
nilotinib Kinase inhibitor No MSN05 Down Heparin-binding EGF-like growth factor receptor signaling 0.048680702 16.5 NaN HBEGF
nilotinib Kinase inhibitor No MSN05 Down Hepatocyte growth factor receptor signaling 0.032721547 14 NaN MET
nilotinib Kinase inhibitor No MSN09 Down HIF-1 receptor signaling pathway 0.014452362 8 NaN CITED2;EGLN3
nilotinib Kinase inhibitor No MSN01 Up Hyaluronan-mediated motility receptor signaling 0.027522936 23.5 NaN HMMR
nilotinib Kinase inhibitor No MSN05 Up Hyaluronan-mediated motility receptor signaling 0.028846154 23 NaN HMMR
nilotinib Kinase inhibitor No MSN06 Up Hyaluronan-mediated motility receptor signaling 0.026464361 25 NaN HMMR
nilotinib Kinase inhibitor No MSN08 Up Hyaluronan-mediated motility receptor signaling 0.027258292 29.5 NaN HMMR
nilotinib Kinase inhibitor No MSN09 Up Hyaluronan-mediated motility receptor signaling 0.025141143 26 NaN HMMR
nilotinib Kinase inhibitor No MSN01 Down Inhibition of amyloid aggregation, amyloid degradation and uptake 7.82E-06 1 NaN A2M;MME;PLAT
nilotinib Kinase inhibitor No MSN01 Up Inhibition of apoptosis 0.041541674 28.5 NaN BIRC5;IFI6
nilotinib Kinase inhibitor No MSN05 Up Inhibition of apoptosis 0.045239205 27.5 NaN BIRC5;IFI6
nilotinib Kinase inhibitor No MSN06 Up Inhibition of apoptosis 0.038673865 28 NaN BIRC5;IFI6
nilotinib Kinase inhibitor No MSN09 Up Inhibition of apoptosis 0.035205397 28 NaN BIRC5;IFI6
nilotinib Kinase inhibitor No MSN01 Up Intracellular bridge assembly 0.002224143 9 NaN INCENP;KIF23
nilotinib Kinase inhibitor No MSN05 Up Intracellular bridge assembly 0.002441309 13 NaN INCENP;KIF23
nilotinib Kinase inhibitor No MSN06 Up Intracellular bridge assembly 0.002057559 12 NaN INCENP;KIF23
nilotinib Kinase inhibitor No MSN08 Up Intracellular bridge assembly 0.002181901 10 NaN INCENP;KIF23
nilotinib Kinase inhibitor No MSN09 Up Intracellular bridge assembly 0.001858288 12 NaN INCENP;KIF23
nilotinib Kinase inhibitor No MSN01 Down JAK-STAT signaling pathway 0.030757337 11 NaN SOCS2;STAT4
nilotinib Kinase inhibitor No MSN01 Up Metaphase to anaphase checkpoint 2.93E-06 3 NaN BUB1;BUB1B;CCNB2;CDC20;CENPE;MAD2L1;PTTG1;TTK
nilotinib Kinase inhibitor No MSN05 Up Metaphase to anaphase checkpoint 4.15E-06 3 NaN BUB1;BUB1B;CCNB2;CDC20;CENPE;MXD3;PTTG1;TTK
nilotinib Kinase inhibitor No MSN06 Up Metaphase to anaphase checkpoint 1.66E-07 3 NaN BUB1;BUB1B;CCNB2;CDC20;CENPE;MAD2L1;MXD3;PTTG1;TTK
nilotinib Kinase inhibitor No MSN08 Up Metaphase to anaphase checkpoint 2.13E-07 3 NaN BUB1;BUB1B;CCNB2;CDC20;CENPE;MAD2L1;MXD3;PTTG1;TTK
nilotinib Kinase inhibitor No MSN09 Up Metaphase to anaphase checkpoint 1.07E-07 3 NaN BUB1;BUB1B;CCNB2;CDC20;CENPE;MAD2L1;MXD3;PTTG1;TTK
nilotinib Kinase inhibitor No MSN01 Down Microfibril scaffold organization 0.039477231 12.5 NaN FBN1
nilotinib Kinase inhibitor No MSN01 Up Mitotic chromosome condensation 0.014470218 18 NaN INCENP;SMC4
nilotinib Kinase inhibitor No MSN05 Up Mitotic chromosome condensation 0.015826754 19.5 NaN INCENP;SMC4
nilotinib Kinase inhibitor No MSN06 Up Mitotic chromosome condensation 0.000593464 9 NaN INCENP;NCAPG2;SMC4
nilotinib Kinase inhibitor No MSN08 Up Mitotic chromosome condensation 0.014205479 23.5 NaN INCENP;SMC4
nilotinib Kinase inhibitor No MSN09 Up Mitotic chromosome condensation 0.000510607 9 NaN INCENP;NCAPG2;SMC4
nilotinib Kinase inhibitor No MSN01 Up Mitotic H3 phosphorylation and dephosphorylation 0.000198188 5 NaN AURKB;CCNA2;INCENP
nilotinib Kinase inhibitor No MSN05 Up Mitotic H3 phosphorylation and dephosphorylation 0.000227809 8 NaN AURKB;CCNA2;INCENP
nilotinib Kinase inhibitor No MSN06 Up Mitotic H3 phosphorylation and dephosphorylation 0.000176406 6.5 NaN AURKB;CCNA2;INCENP
nilotinib Kinase inhibitor No MSN08 Up Mitotic H3 phosphorylation and dephosphorylation 0.000192586 6 NaN AURKB;CCNA2;INCENP
nilotinib Kinase inhibitor No MSN09 Up Mitotic H3 phosphorylation and dephosphorylation 0.000151472 6.5 NaN AURKB;CCNA2;INCENP
nilotinib Kinase inhibitor No MSN01 Up Mitotic spindle assembly 1.64E-05 4 NaN DLGAP5;NUSAP1;TACC3;TPX2;TTK
nilotinib Kinase inhibitor No MSN05 Up Mitotic spindle assembly 2.06E-05 6 NaN DLGAP5;NUSAP1;TACC3;TPX2;TTK
nilotinib Kinase inhibitor No MSN06 Up Mitotic spindle assembly 4.80E-07 4 NaN CKAP2;DLGAP5;NUSAP1;TACC3;TPX2;TTK
nilotinib Kinase inhibitor No MSN08 Up Mitotic spindle assembly 5.71E-07 4 NaN CKAP2;DLGAP5;NUSAP1;TACC3;TPX2;TTK
nilotinib Kinase inhibitor No MSN09 Up Mitotic spindle assembly 3.55E-07 4 NaN CKAP2;DLGAP5;NUSAP1;TACC3;TPX2;TTK
nilotinib Kinase inhibitor No MSN05 Down Z-disc organization 0.002111529 4 NaN CSRP3;PDLIM3;TCAP
nilotinib Kinase inhibitor No MSN06 Down Z-disc organization 1.17E-05 1 NaN ACTN2;CSRP3;DES;PDLIM3;TCAP
nilotinib Kinase inhibitor No MSN08 Down Z-disc organization 8.44E-06 1 NaN ACTN2;CSRP3;LDB3;PDLIM3;TCAP
nilotinib Kinase inhibitor No MSN09 Down Z-disc organization 0.000287224 1 NaN ACTN2;CSRP3;PDLIM3;TCAP
milrinone Vasodilatator Yes MSN05 Down WNT-Beta-catenin signaling pathway 0.020122326 9 NaN AMER1;FRZB;FZD1;SFRP2;SFRP5
milrinone Vasodilatator Yes MSN08 Down WNT-Beta-catenin signaling pathway 0.020402338 11 NaN APCDD1;FZD7;SFRP1;SFRP2;SFRP5
milrinone Vasodilatator Yes MSN09 Down WNT-Beta-catenin signaling pathway 0.000123641 1 NaN AMER1;FRZB;FZD7;PAX6;SFRP2;SFRP5;WNT5A;WNT9A
milrinone Vasodilatator Yes MSN05 Up Z-disc organization 0.035163828 18 NaN DES;TCAP
milrinone Vasodilatator Yes MSN06 Up Z-disc organization 0.039201142 13.5 NaN DES;TCAP
milrinone Vasodilatator Yes MSN08 Up Z-disc organization 0.003524647 2 NaN CSRP3;DES;TCAP
milrinone Vasodilatator Yes MSN01 Down Mitotic spindle assembly 0.038858469 14.5 NaN TACC3;TPX2
milrinone Vasodilatator Yes MSN05 Down Mitotic spindle assembly 0.039114857 18.5 NaN TACC3;TPX2
milrinone Vasodilatator Yes MSN05 Up Natriuretic peptide receptor signaling 0.004969189 5 NaN NPPA;NPR1
milrinone Vasodilatator Yes MSN06 Up Natriuretic peptide receptor signaling 0.0055816 5 NaN NPPA;NPPB
milrinone Vasodilatator Yes MSN01 Down Osteonectin receptor signaling 0.003455479 3 NaN SMOC2;SPOCK1
milrinone Vasodilatator Yes MSN02 Down Osteonectin receptor signaling 0.003190191 6 NaN SPARC;SPOCK1
milrinone Vasodilatator Yes MSN05 Down Osteonectin receptor signaling 0.003480103 6.5 NaN SMOC2;SPOCK1
milrinone Vasodilatator Yes MSN06 Down Osteonectin receptor signaling 0.003455479 6 NaN SMOC2;SPOCK1
milrinone Vasodilatator Yes MSN08 Down Osteonectin receptor signaling 5.79E-05 1 NaN SMOC2;SPARC;SPOCK1
milrinone Vasodilatator Yes MSN09 Down Osteonectin receptor signaling 0.003237663 6.5 NaN SPARC;SPOCK1
milrinone Vasodilatator Yes MSN02 Up Osteopontin receptor signaling 0.0200247 9.5 NaN SPP1
milrinone Vasodilatator Yes MSN05 Up Osteopontin receptor signaling 0.018701482 15 NaN SPP1
milrinone Vasodilatator Yes MSN06 Up Osteopontin receptor signaling 0.019848271 8 NaN SPP1
milrinone Vasodilatator Yes MSN08 Up Osteopontin receptor signaling 0.019760056 9 NaN SPP1
milrinone Vasodilatator Yes MSN09 Up Osteopontin receptor signaling 0.020289344 6 NaN SPP1
milrinone Vasodilatator Yes MSN09 Up Phase I biotransformation via cytochrome P450 0.010587731 3 NaN CYP1A1;CYP1B1
milrinone Vasodilatator Yes MSN01 Up Platelet-derived growth factor receptor signaling 0.018691388 7 NaN PDGFRA;RGS5
milrinone Vasodilatator Yes MSN05 Up Platelet-derived growth factor receptor signaling 0.017132206 13 NaN PDGFRB;RGS5
milrinone Vasodilatator Yes MSN02 Down Platelet-derived growth factor receptor signaling 0.026236809 14 NaN FOSL1;PDGFB
milrinone Vasodilatator Yes MSN06 Down Platelet-derived growth factor receptor signaling 0.002058855 4 NaN PDGFB;PDGFRA;TNK2
milrinone Vasodilatator Yes MSN08 Down Platelet-derived growth factor receptor signaling 0.00210169 5 NaN FOSL1;PDGFB;TNK2
milrinone Vasodilatator Yes MSN09 Up Potassium transmembrane transport 0.001274711 1 NaN ABCC9;ATP1A2;ATP1A3;KCNE4
milrinone Vasodilatator Yes MSN01 Down Progesterone receptor signaling 0.024435427 11 NaN PGR
milrinone Vasodilatator Yes MSN02 Down Progesterone receptor signaling 0.023465067 12.5 NaN PGR
milrinone Vasodilatator Yes MSN05 Down Progesterone receptor signaling 0.024523641 14 NaN PGR
milrinone Vasodilatator Yes MSN06 Down Progesterone receptor signaling 0.024435427 14 NaN PGR
milrinone Vasodilatator Yes MSN08 Down Progesterone receptor signaling 0.024611856 15 NaN PGR
milrinone Vasodilatator Yes MSN09 Down Progesterone receptor signaling 0.023641496 12 NaN PGR
milrinone Vasodilatator Yes MSN01 Up Prostaglandin PGF2 alpha receptor signaling 0.03878543 13 NaN PTGFR
milrinone Vasodilatator Yes MSN06 Up Protein polyubiquitination 0.039201142 13.5 NaN ISG15;UBC
milrinone Vasodilatator Yes MSN01 Down Protein polyubiquitination 0.006383649 6 NaN ISG15;UBE2S;UCHL1
milrinone Vasodilatator Yes MSN02 Down Removal of caspase inhibition 0.046381546 20 NaN XAF1
milrinone Vasodilatator Yes MSN05 Down Removal of caspase inhibition 0.048447984 23 NaN XAF1
milrinone Vasodilatator Yes MSN06 Down Removal of caspase inhibition 0.048275867 22 NaN XAF1
milrinone Vasodilatator Yes MSN08 Down Removal of caspase inhibition 0.048620086 21.5 NaN XAF1
milrinone Vasodilatator Yes MSN09 Down Removal of caspase inhibition 0.046726108 18.5 NaN XAF1
milrinone Vasodilatator Yes MSN01 Up Restriction point 0.015490863 6 NaN CDKN2A;PFKFB3
milrinone Vasodilatator Yes MSN05 Up Restriction point 0.014190421 12 NaN CDKN2A;PFKFB3
milrinone Vasodilatator Yes MSN05 Down Restriction point 0.023680597 10.5 NaN CCND2;CDKN1A
milrinone Vasodilatator Yes MSN06 Up Retinol metabolism 0.02648975 10 NaN ALDH1A2;RBP1
milrinone Vasodilatator Yes MSN01 Down Retinol metabolism 0.038858469 14.5 NaN ALDH1A1;RLBP1
milrinone Vasodilatator Yes MSN02 Down Retinol metabolism 0.036082859 15.5 NaN ALDH1A3;RLBP1
milrinone Vasodilatator Yes MSN05 Down Retinol metabolism 0.039114857 18.5 NaN ALDH1A1;RLBP1
milrinone Vasodilatator Yes MSN06 Down Retinol metabolism 0.000209572 2 NaN ALDH1A3;CYP26A1;DHRS3;RLBP1
milrinone Vasodilatator Yes MSN08 Down Retinol metabolism 0.00351239 6.5 NaN ALDH1A3;RLBP1;TTR
milrinone Vasodilatator Yes MSN09 Down Retinol metabolism 0.036581377 15 NaN ALDH1A1;RLBP1
milrinone Vasodilatator Yes MSN02 Up Semaphorin signaling 0.030054908 12 NaN NRP2;PLXNC1;PLXND1
milrinone Vasodilatator Yes MSN02 Up Serine and glycine metabolism 0.019493118 8 NaN PHGDH;PSAT1
milrinone Vasodilatator Yes MSN01 Down Serine and glycine metabolism 0.028290753 13 NaN PHGDH;SHMT2
milrinone Vasodilatator Yes MSN02 Down Serine and glycine metabolism 0.001833111 4 NaN GLDC;SHMT2;SLC1A5
milrinone Vasodilatator Yes MSN05 Down Serine and glycine metabolism 0.000101959 1 NaN GLDC;PHGDH;SHMT2;SLC1A5
milrinone Vasodilatator Yes MSN06 Down Serine and glycine metabolism 0.000100542 1 NaN GLDC;PHGDH;SHMT2;SLC1A5
milrinone Vasodilatator Yes MSN08 Down Serine and glycine metabolism 0.00010339 3 NaN GLDC;PHGDH;SHMT2;SLC1A5
milrinone Vasodilatator Yes MSN09 Down Serine and glycine metabolism 0.001872928 4 NaN GLDC;PHGDH;SHMT2
milrinone Vasodilatator Yes MSN02 Up Serotonin inactivation 0.039650143 16.5 NaN MAOA
milrinone Vasodilatator Yes MSN01 Down Serotonin inactivation 0.048275867 18.5 NaN MAOA
milrinone Vasodilatator Yes MSN05 Down Serotonin inactivation 0.048447984 23 NaN MAOA
milrinone Vasodilatator Yes MSN06 Down Serotonin inactivation 0.048275867 22 NaN MAOA
milrinone Vasodilatator Yes MSN09 Down Serotonin inactivation 0.046726108 18.5 NaN MAOA
milrinone Vasodilatator Yes MSN01 Down Sister chromatid attachment to mitotic spindle 0.048275867 18.5 NaN TACC3
milrinone Vasodilatator Yes MSN05 Down Sister chromatid attachment to mitotic spindle 0.048447984 23 NaN TACC3
milrinone Vasodilatator Yes MSN06 Down Sodium transmembrane transport 0.042501734 19 NaN ATP1A2;SCN3A;SLC38A2
milrinone Vasodilatator Yes MSN05 Down Tenascin receptor signaling 0.003480103 6.5 NaN TENM1;TNC
milrinone Vasodilatator Yes MSN09 Down Tenascin receptor signaling 0.003237663 6.5 NaN TENM1;TNC
milrinone Vasodilatator Yes MSN02 Up Thin myofilament organization 0.007845779 5.5 NaN ACTA1;LMOD3
milrinone Vasodilatator Yes MSN05 Up Thin myofilament organization 0.006871448 8 NaN ACTA1;LMOD3
milrinone Vasodilatator Yes MSN09 Down Thin myofilament organization 0.010811186 8 NaN ACTA1;TNNI3
milrinone Vasodilatator Yes MSN01 Up Thrombospondin receptor signaling 0.002232086 1 NaN THBS1;THBS2
milrinone Vasodilatator Yes MSN05 Up Thrombospondin receptor signaling 0.002037514 3.5 NaN THBS1;THBS2
milrinone Vasodilatator Yes MSN02 Down Tight junction organization 0.044793664 17 NaN CLDN19;CRB2;MYLK
milrinone Vasodilatator Yes MSN05 Down Tight junction organization 0.049939927 27 NaN CLDN19;CRB2;MYLK
milrinone Vasodilatator Yes MSN09 Down Tight junction organization 0.045631721 16 NaN CGNL1;CLDN19;MYLK
milrinone Vasodilatator Yes MSN01 Down Tropoelastin synthesis 0.024435427 11 NaN ELN
milrinone Vasodilatator Yes MSN02 Down Tropoelastin synthesis 0.023465067 12.5 NaN ELN
milrinone Vasodilatator Yes MSN05 Down Tropoelastin synthesis 0.024523641 14 NaN ELN
milrinone Vasodilatator Yes MSN06 Down Tropoelastin synthesis 0.024435427 14 NaN ELN
milrinone Vasodilatator Yes MSN08 Down Tropoelastin synthesis 0.024611856 15 NaN ELN
milrinone Vasodilatator Yes MSN05 Up Vascular endothelial growth factor receptor signaling 0.006871448 8 NaN KDR;VEGFA
milrinone Vasodilatator Yes MSN02 Down Vasoactive intestinal peptide receptor signaling 0.046381546 20 NaN VIPR2
milrinone Vasodilatator Yes MSN05 Down Vasoactive intestinal peptide receptor signaling 0.048447984 23 NaN VIPR2
milrinone Vasodilatator Yes MSN01 Down Versican receptor signaling 0.048275867 18.5 NaN VCAN
milrinone Vasodilatator Yes MSN05 Down Versican receptor signaling 0.048447984 23 NaN VCAN
milrinone Vasodilatator Yes MSN06 Down Versican receptor signaling 0.048275867 22 NaN VCAN
milrinone Vasodilatator Yes MSN08 Down Versican receptor signaling 0.048620086 21.5 NaN VCAN
milrinone Vasodilatator Yes MSN09 Down Versican receptor signaling 0.046726108 18.5 NaN VCAN
milrinone Vasodilatator Yes MSN01 Down Versican synthesis 0.024435427 11 NaN VCAN
milrinone Vasodilatator Yes MSN05 Down Versican synthesis 0.024523641 14 NaN VCAN
milrinone Vasodilatator Yes MSN06 Down Versican synthesis 0.024435427 14 NaN VCAN
milrinone Vasodilatator Yes MSN08 Down Versican synthesis 0.024611856 15 NaN VCAN
milrinone Vasodilatator Yes MSN09 Down Versican synthesis 0.023641496 12 NaN VCAN
milrinone Vasodilatator Yes MSN02 Down Actin filament severing and depolymerization 0.036082859 15.5 NaN SCIN;TAGLN2
milrinone Vasodilatator Yes MSN06 Down Actin filament severing and depolymerization 0.038858469 18 NaN SCIN;TAGLN2
milrinone Vasodilatator Yes MSN08 Down Actin filament severing and depolymerization 0.039371914 18.5 NaN SCIN;TAGLN2
milrinone Vasodilatator Yes MSN01 Up Adenylyl cyclase signaling pathway 0.004865296 2 NaN ADCY1;PDE3A;RAPGEF4
milrinone Vasodilatator Yes MSN05 Up Adenylyl cyclase signaling pathway 0.04375734 23 NaN PDE3A;RAPGEF4
milrinone Vasodilatator Yes MSN06 Up Adenylyl cyclase signaling pathway 0.048709404 19 NaN PDE3A;RAPGEF4
milrinone Vasodilatator Yes MSN01 Up Adrenergic receptor signaling 0.013821647 5 NaN ADCY2;GPR3;RAPGEF4
milrinone Vasodilatator Yes MSN02 Down Adrenergic receptor signaling 0.022299004 11 NaN ADRB1;ADRB3;ARRB1
milrinone Vasodilatator Yes MSN05 Down Aggrecan synthesis 0.024523641 14 NaN ACAN
milrinone Vasodilatator Yes MSN06 Down Aggrecan synthesis 0.024435427 14 NaN ACAN
milrinone Vasodilatator Yes MSN08 Down Aggrecan synthesis 0.024611856 15 NaN ACAN
milrinone Vasodilatator Yes MSN01 Up Albumin mediated blood protein transport 0.019583627 8.5 NaN ALB
milrinone Vasodilatator Yes MSN05 Up Albumin mediated blood protein transport 0.018701482 15 NaN ALB
milrinone Vasodilatator Yes MSN06 Up Albumin mediated blood protein transport 0.019848271 8 NaN ALB
milrinone Vasodilatator Yes MSN08 Up Albumin mediated blood protein transport 0.019760056 9 NaN ALB
milrinone Vasodilatator Yes MSN09 Up Albumin mediated blood protein transport 0.020289344 6 NaN ALB
milrinone Vasodilatator Yes MSN02 Up Alternative complement pathway 0.003836392 3 NaN C3;CFH
milrinone Vasodilatator Yes MSN08 Down Androgen synthesis 0.019383609 9 NaN HSD17B2;SRD5A2
milrinone Vasodilatator Yes MSN02 Down Antigen presentation via MHC class I molecules 0.001356597 2 NaN HLA-A;HLA-B;HLA-C
milrinone Vasodilatator Yes MSN05 Down Antigen presentation via MHC class I molecules 0.023680597 10.5 NaN HLA-B;HLA-C
milrinone Vasodilatator Yes MSN06 Down Antigen presentation via MHC class I molecules 0.023521317 10.5 NaN HLA-A;HLA-C
milrinone Vasodilatator Yes MSN08 Down Antigen presentation via MHC class I molecules 0.023840336 12 NaN HLA-A;HLA-C
milrinone Vasodilatator Yes MSN09 Down Antigen presentation via MHC class I molecules 0.022108594 10 NaN HLA-B;HLA-C
milrinone Vasodilatator Yes MSN02 Up Axonal intermediate filament dynamics 0.007845779 5.5 NaN NEFH;NEFM
milrinone Vasodilatator Yes MSN08 Up Axonal intermediate filament dynamics 0.007646107 7 NaN NEFH;NES
milrinone Vasodilatator Yes MSN01 Up Biglycan synthesis 0.019583627 8.5 NaN BGN
milrinone Vasodilatator Yes MSN02 Up Biglycan synthesis 0.0200247 9.5 NaN BGN
milrinone Vasodilatator Yes MSN05 Up Biglycan synthesis 0.018701482 15 NaN BGN
milrinone Vasodilatator Yes MSN06 Up Biglycan synthesis 0.019848271 8 NaN BGN
milrinone Vasodilatator Yes MSN08 Up Biglycan synthesis 0.019760056 9 NaN BGN
milrinone Vasodilatator Yes MSN09 Up Biglycan synthesis 0.020289344 6 NaN BGN
milrinone Vasodilatator Yes MSN02 Down Bone morphogenetic protein receptor signaling 0.001553323 3 NaN BMP2;BMP6;BMP7;NOG
milrinone Vasodilatator Yes MSN01 Up Cardiomyocyte repolarization during action potential and hyperpolarization 0.029759296 10 NaN KCNIP2;KCNJ12
milrinone Vasodilatator Yes MSN02 Up Cardiomyocyte repolarization during action potential and hyperpolarization 0.031008959 13.5 NaN KCNIP2;KCNJ2
milrinone Vasodilatator Yes MSN06 Up Cardiomyocyte repolarization during action potential and hyperpolarization 0.030506558 11.5 NaN KCNIP2;KCNJ2
milrinone Vasodilatator Yes MSN09 Up Cardiomyocyte repolarization during action potential and hyperpolarization 0.031768858 10.5 NaN KCNA1;KCNIP2
milrinone Vasodilatator Yes MSN02 Down CCN intercellular signaling protein family receptor signaling 0.005234736 7.5 NaN CYR61;WISP1
milrinone Vasodilatator Yes MSN06 Down CCN intercellular signaling protein family receptor signaling 0.005666345 7 NaN CYR61;NOV
milrinone Vasodilatator Yes MSN08 Down CCN intercellular signaling protein family receptor signaling 0.000142188 4 NaN CTGF;CYR61;NOV
milrinone Vasodilatator Yes MSN02 Down CD44-Mediated leukocyte rolling 0.046381546 20 NaN CD44
milrinone Vasodilatator Yes MSN06 Down CD44-Mediated leukocyte rolling 0.048275867 22 NaN CD44
milrinone Vasodilatator Yes MSN08 Down CD44-Mediated leukocyte rolling 0.048620086 21.5 NaN CD44
milrinone Vasodilatator Yes MSN02 Down Cellular cholesterol uptake and efflux 0.003068795 5 NaN ABCA1;ABCG1;SCARA3
milrinone Vasodilatator Yes MSN05 Down Cellular cholesterol uptake and efflux 0.003476939 5 NaN ABCA1;ABCG1;SCARA3
milrinone Vasodilatator Yes MSN09 Down Cellular cholesterol uptake and efflux 0.003134623 5 NaN ABCA1;ABCG1;SCARA3
milrinone Vasodilatator Yes MSN02 Up Cellular iron uptake and export 0.026929091 11 NaN RASD1;TFRC
milrinone Vasodilatator Yes MSN09 Up Cellular iron uptake and export 0.027593758 8 NaN TF;TFRC
milrinone Vasodilatator Yes MSN08 Down Cellular iron uptake and export 0.039371914 18.5 NaN CP;TFRC
milrinone Vasodilatator Yes MSN02 Up Centrosome separation 0.01616 7 NaN KIF11;SPAG5
milrinone Vasodilatator Yes MSN06 Down Centrosome separation 0.023521317 10.5 NaN CCNB1;NEK6
milrinone Vasodilatator Yes MSN01 Up Chaperone-mediated autophagy 0.03878543 13 NaN HSPA8
milrinone Vasodilatator Yes MSN05 Up Chaperone-mediated autophagy 0.037054838 20 NaN HSPA8
milrinone Vasodilatator Yes MSN06 Up Chaperone-mediated autophagy 0.039304304 16.5 NaN HSPA8
milrinone Vasodilatator Yes MSN09 Up Chaperone-mediated autophagy 0.040168784 14.5 NaN HSPA8
milrinone Vasodilatator Yes MSN02 Up Cholesterol synthesis 0.000589508 1 NaN FDPS;HMGCR;HMGCS1;MVD
milrinone Vasodilatator Yes MSN05 Up Cholesterol synthesis 0.005812705 6 NaN HMGCS1;MSMO1;SC5D
milrinone Vasodilatator Yes MSN01 Down Cholesterol synthesis 0.012093552 8 NaN FDFT1;MVD;MVK
milrinone Vasodilatator Yes MSN08 Up Cholesterol-sensitive control of SREBP activation 0.005533298 5.5 NaN INSIG1;SREBF1
milrinone Vasodilatator Yes MSN01 Up Classical complement pathway 0.007514323 3 NaN C4A;C4B
milrinone Vasodilatator Yes MSN05 Up Classical complement pathway 0.006871448 8 NaN C4A;C4B
milrinone Vasodilatator Yes MSN02 Down Classical complement pathway 0.010656442 9 NaN C1R;C1S
milrinone Vasodilatator Yes MSN08 Down Classical complement pathway 0.011680465 8 NaN C1QB;C1QC
milrinone Vasodilatator Yes MSN09 Up Clathrin-mediated vesicle traffic from TGN to endosomal lysosomal system 0.031768858 10.5 NaN AP1G2;AP1S2
milrinone Vasodilatator Yes MSN02 Up Collagen fibril organization by fibril-associated bridges 0.005678798 4 NaN COL9A1;COL9A2
milrinone Vasodilatator Yes MSN08 Up Collagen fibril organization by fibril-associated bridges 0.005533298 5.5 NaN COL9A1;COL9A2
milrinone Vasodilatator Yes MSN01 Down Collagen fibril organization by fibril-associated bridges 0.008362857 7 NaN COL14A1;COL9A2
milrinone Vasodilatator Yes MSN02 Down Contractile ring constriction 0.005234736 7.5 NaN MYH14;MYLK
milrinone Vasodilatator Yes MSN05 Down Decorin synthesis 0.024523641 14 NaN DCN
milrinone Vasodilatator Yes MSN06 Down Decorin synthesis 0.024435427 14 NaN DCN
milrinone Vasodilatator Yes MSN08 Down Decorin synthesis 0.024611856 15 NaN DCN
milrinone Vasodilatator Yes MSN09 Down Decorin synthesis 0.023641496 12 NaN DCN
milrinone Vasodilatator Yes MSN08 Up Eicosanoid metabolism 0.034464443 11 NaN PLA2G2A;PTGS1
milrinone Vasodilatator Yes MSN08 Up Endogenous control of complement activity 0.003737436 3.5 NaN CFH;CFI
milrinone Vasodilatator Yes MSN01 Up Extracellular matrix breakdown and membrane shedding by adamalysins 0.011071787 4 NaN ADAM12;ADAMTS12;ADAMTS14
milrinone Vasodilatator Yes MSN06 Up Extracellular matrix breakdown and membrane shedding by adamalysins 0.001175038 2 NaN ADAM12;ADAMTS14;ADAMTS2;ADAMTS5
milrinone Vasodilatator Yes MSN08 Up Extracellular matrix breakdown and membrane shedding by adamalysins 0.001155785 1 NaN ADAM33;ADAMTS14;ADAMTS2;ADAMTS5
milrinone Vasodilatator Yes MSN06 Down Extracellular matrix breakdown and membrane shedding by adamalysins 0.019988845 9 NaN ADAMTS1;ADAMTS7;ADAMTS8
milrinone Vasodilatator Yes MSN08 Down Extracellular matrix breakdown and membrane shedding by adamalysins 0.020370269 10 NaN ADAMTS1;ADAMTS7;ADAMTS8
milrinone Vasodilatator Yes MSN05 Up Extracellular matrix breakdown by matrix metalloproteases 0.011492797 10.5 NaN MMP1;MMP2
milrinone Vasodilatator Yes MSN09 Up Fibrillar collagen core structure organization 0.016567476 4 NaN COL2A1;COL5A2
milrinone Vasodilatator Yes MSN01 Down Fibrillar collagen core structure organization 0.023521317 9 NaN COL11A1;COL1A1
milrinone Vasodilatator Yes MSN02 Down Fibrillar collagen core structure organization 5.57E-05 1 NaN COL1A1;COL1A2;COL2A1;COL5A1
milrinone Vasodilatator Yes MSN05 Down Fibrillar collagen core structure organization 0.001540682 3 NaN COL1A1;COL1A2;COL3A1
milrinone Vasodilatator Yes MSN06 Down Fibrillar collagen core structure organization 0.00152477 3 NaN COL1A2;COL2A1;COL3A1
milrinone Vasodilatator Yes MSN08 Down Fibrillar collagen core structure organization 6.71E-05 2 NaN COL1A1;COL1A2;COL2A1;COL5A2
milrinone Vasodilatator Yes MSN09 Down Fibrillar collagen core structure organization 0.001386247 3 NaN COL1A1;COL1A2;COL3A1
milrinone Vasodilatator Yes MSN06 Up Fibronectin synthesis and extracellular assembly 0.003770283 4 NaN FN1;ITGB3
milrinone Vasodilatator Yes MSN08 Up Fibronectin synthesis and extracellular assembly 0.003737436 3.5 NaN FN1;ITGB3
milrinone Vasodilatator Yes MSN09 Up Fibronectin synthesis and extracellular assembly 0.003936586 2 NaN FN1;ITGB3
milrinone Vasodilatator Yes MSN02 Down Fibulin receptor signaling 0.046381546 20 NaN FBLN1
milrinone Vasodilatator Yes MSN09 Down Fibulin receptor signaling 0.046726108 18.5 NaN FBLN1
milrinone Vasodilatator Yes MSN06 Down GABA metabolism 0.008362857 8 NaN ABAT;SLC6A1
milrinone Vasodilatator Yes MSN05 Up Gap junction organization 0.027324073 17 NaN GJA1;GJA5
milrinone Vasodilatator Yes MSN09 Up Gap junction organization 0.031768858 10.5 NaN GJA1;GJA5
milrinone Vasodilatator Yes MSN01 Down Glutamate and glutamine metabolism 0.003441711 2 NaN SLC1A3;SLC38A2;SLC7A5
milrinone Vasodilatator Yes MSN05 Down Glutamate and glutamine metabolism 0.000212495 2 NaN SLC1A3;SLC1A5;SLC38A2;SLC7A5
milrinone Vasodilatator Yes MSN06 Down Glutamate and glutamine metabolism 0.003441711 5 NaN SLC1A5;SLC38A2;SLC7A5
milrinone Vasodilatator Yes MSN08 Down Glutamate and glutamine metabolism 0.00351239 6.5 NaN SLC1A5;SLC38A2;SLC7A5
milrinone Vasodilatator Yes MSN02 Down Glycolysis and Gluconeogenesis 0.015989849 10 NaN LDHA;PFKL;TPI1
milrinone Vasodilatator Yes MSN05 Down Glycolysis and Gluconeogenesis 0.002169178 4 NaN ALDOA;LDHA;PCK2;PFKL
milrinone Vasodilatator Yes MSN09 Down Glycolysis and Gluconeogenesis 0.016311637 9 NaN ALDOA;LDHA;PFKL
milrinone Vasodilatator Yes MSN02 Up Granulocyte macrophage colony-stimulating factor receptor signaling 0.039650143 16.5 NaN JAK2
milrinone Vasodilatator Yes MSN05 Up Granulocyte macrophage colony-stimulating factor receptor signaling 0.037054838 20 NaN JAK2
milrinone Vasodilatator Yes MSN09 Up Granulocyte macrophage colony-stimulating factor receptor signaling 0.040168784 14.5 NaN JAK2
milrinone Vasodilatator Yes MSN01 Down Granulocyte macrophage colony-stimulating factor receptor signaling 0.048275867 18.5 NaN JUND
milrinone Vasodilatator Yes MSN05 Down Granulocyte macrophage colony-stimulating factor receptor signaling 0.048447984 23 NaN JUND
milrinone Vasodilatator Yes MSN06 Down Granulocyte macrophage colony-stimulating factor receptor signaling 0.048275867 22 NaN JUND
milrinone Vasodilatator Yes MSN05 Up Granulocyte-colony stimulating factor receptor signaling 0.011492797 10.5 NaN SOCS3;STAT3
milrinone Vasodilatator Yes MSN06 Up Granulocyte-colony stimulating factor receptor signaling 0.012879711 6 NaN SOCS3;STAT3
milrinone Vasodilatator Yes MSN01 Down Hepatocyte growth factor receptor signaling 0.000594987 1 NaN HGF;MET
milrinone Vasodilatator Yes MSN05 Down Hepatocyte growth factor receptor signaling 0.048447984 23 NaN MET
milrinone Vasodilatator Yes MSN09 Down Hepatocyte growth factor receptor signaling 0.000556884 2 NaN HGF;MET
milrinone Vasodilatator Yes MSN02 Up Inhibition of amyloid aggregation, amyloid degradation and uptake 0.00118192 2 NaN A2M;MME
milrinone Vasodilatator Yes MSN05 Up Inhibition of amyloid aggregation, amyloid degradation and uptake 6.45E-06 1 NaN A2M;MME;PLAT
milrinone Vasodilatator Yes MSN06 Up Inhibition of amyloid aggregation, amyloid degradation and uptake 0.001161278 1 NaN A2M;MME
milrinone Vasodilatator Yes MSN09 Down Inhibition of apoptosis 0.031435723 14 NaN IFI6;XAF1
milrinone Vasodilatator Yes MSN01 Down Inositol metabolism and transport 0.048275867 18.5 NaN SLC5A3
milrinone Vasodilatator Yes MSN08 Down Inositol metabolism and transport 0.048620086 21.5 NaN INPP5D
milrinone Vasodilatator Yes MSN02 Down Insulin receptor signaling 0.04710941 23 NaN IRS1;IRS2
milrinone Vasodilatator Yes MSN09 Down Insulin receptor signaling 0.047749388 21 NaN IRS1;IRS2
milrinone Vasodilatator Yes MSN01 Up Interleukin 6 receptor signaling 0.03878543 13 NaN JAK3
milrinone Vasodilatator Yes MSN06 Up Interleukin 6 receptor signaling 0.039304304 16.5 NaN JAK3
milrinone Vasodilatator Yes MSN08 Up Interleukin 6 receptor signaling 0.039131362 13 NaN JAK3
milrinone Vasodilatator Yes MSN01 Up Interleukin 7 receptor signaling 0.03878543 13 NaN JAK3
milrinone Vasodilatator Yes MSN06 Up Interleukin 7 receptor signaling 0.039304304 16.5 NaN JAK3
milrinone Vasodilatator Yes MSN08 Up Interleukin 7 receptor signaling 0.039131362 13 NaN JAK3
milrinone Vasodilatator Yes MSN02 Up JAK-STAT signaling pathway 0.031008959 13.5 NaN SOCS2;STAT4
milrinone Vasodilatator Yes MSN05 Up JAK-STAT signaling pathway 0.002015723 2 NaN SOCS2;SOCS3;STAT3
milrinone Vasodilatator Yes MSN06 Up JAK-STAT signaling pathway 0.030506558 11.5 NaN SOCS3;STAT3
milrinone Vasodilatator Yes MSN09 Up JAK-STAT signaling pathway 0.031768858 10.5 NaN SOCS3;STAT4
milrinone Vasodilatator Yes MSN05 Up Leptin receptor signaling 0.002037514 3.5 NaN SOCS3;STAT3
milrinone Vasodilatator Yes MSN06 Up Leptin receptor signaling 0.00229214 3 NaN SOCS3;STAT3
milrinone Vasodilatator Yes MSN01 Down Lipogenesis 0.048275867 18.5 NaN FASN
milrinone Vasodilatator Yes MSN01 Down Macrophage migration inhibitory factor signaling 0.005666345 4 NaN CXCR4;JUND
milrinone Vasodilatator Yes MSN05 Down Macrophage migration inhibitory factor signaling 0.005706386 8 NaN CXCR4;JUND
milrinone Vasodilatator Yes MSN02 Up Mammalian target of rapamycin signaling pathway 0.044565529 19 NaN DDIT4;RICTOR
milrinone Vasodilatator Yes MSN05 Up Mammalian target of rapamycin signaling pathway 0.039370586 22 NaN DDIT4;RICTOR
milrinone Vasodilatator Yes MSN09 Up Mammalian target of rapamycin signaling pathway 0.045634248 17 NaN DDIT4;RICTOR
milrinone Vasodilatator Yes MSN01 Down MAPK signaling pathway 0.005795587 5 NaN DUSP1;FOXM1;MAP2K6;RPS6KA2
milrinone Vasodilatator Yes MSN05 Down MAPK signaling pathway 0.036370558 17 NaN DUSP1;MAP2K6;RPS6KA2
milrinone Vasodilatator Yes MSN06 Down MAPK signaling pathway 0.036041409 17 NaN DUSP1;MAP2K6;RPS6KA2
milrinone Vasodilatator Yes MSN02 Up Methionine cycle 0.039650143 16.5 NaN BHMT
milrinone Vasodilatator Yes MSN08 Up Methionine cycle 0.039131362 13 NaN BHMT
milrinone Vasodilatator Yes MSN09 Up Methionine cycle 0.040168784 14.5 NaN BHMT
milrinone Vasodilatator Yes MSN01 Up Microfibril scaffold organization 0.03878543 13 NaN FBN1
milrinone Vasodilatator Yes MSN02 Up Microfibril scaffold organization 0.039650143 16.5 NaN MFAP2
milrinone Vasodilatator Yes MSN05 Up Microfibril scaffold organization 0.037054838 20 NaN FBN1
milrinone Vasodilatator Yes MSN06 Up Microfibril scaffold organization 0.039304304 16.5 NaN FBN1
milrinone Vasodilatator Yes MSN09 Up Microfibril scaffold organization 0.040168784 14.5 NaN FBN1
milrinone Vasodilatator Yes MSN02 Down Microfibril scaffold organization 0.046381546 20 NaN FBN1
lapatinib Kinase inhibitor Yes MSN05 Down Eukaryotic kinetochore dynamics 6.94E-08 2 NaN BUB1;CENPE;CENPF;CENPU;MAD2L1;NDC80;NUF2;SPC24;TTK;ZWINT
lapatinib Kinase inhibitor Yes MSN08 Down Eukaryotic kinetochore dynamics 5.78E-06 2 NaN BUB1;CENPE;CENPF;CENPU;NDC80;SPC24;TTK;ZWINT
lapatinib Kinase inhibitor Yes MSN09 Down Eukaryotic kinetochore dynamics 0.000534725 3 NaN BUB1;CENPE;CENPF;CENPU;SPC24;TTK
lapatinib Kinase inhibitor Yes MSN01 Up Extracellular matrix breakdown and membrane shedding by adamalysins 0.017257201 13 NaN ADAM33;ADAMTS10;ADAMTS7
lapatinib Kinase inhibitor Yes MSN05 Up Extracellular matrix breakdown and membrane shedding by adamalysins 0.008219515 6.5 NaN ADAM33;ADAMTS14;ADAMTS5
lapatinib Kinase inhibitor Yes MSN06 Up Extracellular matrix breakdown and membrane shedding by adamalysins 0.012182779 9.5 NaN ADAM12;ADAM33;ADAMTS2
lapatinib Kinase inhibitor Yes MSN09 Up Extracellular matrix breakdown and membrane shedding by adamalysins 0.000941768 3 NaN ADAM33;ADAMTS10;ADAMTS2;ADAMTS5
lapatinib Kinase inhibitor Yes MSN06 Down Extracellular matrix breakdown and membrane shedding by adamalysins 0.002829744 4 NaN ADAMTS1;ADAMTS12;ADAMTS15;ADAMTS17
lapatinib Kinase inhibitor Yes MSN09 Down Extracellular matrix breakdown and membrane shedding by adamalysins 0.027026538 18 NaN ADAM19;ADAMTS12;ADAMTS8
lapatinib Kinase inhibitor Yes MSN06 Down Extracellular matrix breakdown by cathepsins 0.02497131 15 NaN CTSB;CTSF
lapatinib Kinase inhibitor Yes MSN08 Down Extracellular matrix breakdown by cathepsins 0.02780993 22.5 NaN CTSB;CTSV
lapatinib Kinase inhibitor Yes MSN01 Up Extracellular matrix breakdown by heparanases and sulfatases 0.003096266 5.5 NaN SULF1;SULF2
lapatinib Kinase inhibitor Yes MSN06 Down Extracellular matrix breakdown by matrix metalloproteases 0.001192421 3 NaN MMP14;MMP2;MMP3
lapatinib Kinase inhibitor Yes MSN05 Down Fanconi anemia interstrand cross-link repair pathway 0.00072133 11 NaN BRCA2;BRIP1;FANCD2;FANCI;UBE2T
lapatinib Kinase inhibitor Yes MSN08 Down Fanconi anemia interstrand cross-link repair pathway 0.031215289 24 NaN BRIP1;FANCD2;FANCI
lapatinib Kinase inhibitor Yes MSN06 Up Fibrillar collagen core structure organization 0.016567476 12 NaN COL11A1;COL2A1
lapatinib Kinase inhibitor Yes MSN06 Down Fibrillar collagen core structure organization 7.39E-05 1 NaN COL11A2;COL1A1;COL1A2;COL3A1
lapatinib Kinase inhibitor Yes MSN09 Down Fibrillar collagen core structure organization 0.029190037 24 NaN COL1A2;COL2A1
lapatinib Kinase inhibitor Yes MSN01 Down Fibroblast growth factor receptor signaling 0.027637833 14 NaN FGF1;FGF10
lapatinib Kinase inhibitor Yes MSN06 Down Fibroblast growth factor receptor signaling 0.035432532 21 NaN FGF1;FGF10
lapatinib Kinase inhibitor Yes MSN01 Up Fibulin receptor signaling 0.045692235 18.5 NaN FBLN1
lapatinib Kinase inhibitor Yes MSN06 Up Fibulin receptor signaling 0.040168784 15 NaN FBLN1
lapatinib Kinase inhibitor Yes MSN08 Down G2 M transition checkpoint 0.039383166 25.5 NaN CCNB1;CDK1
lapatinib Kinase inhibitor Yes MSN01 Down Glutamate and glutamine metabolism 0.0025731 3.5 NaN SLC1A5;SLC38A2;SLC7A5
lapatinib Kinase inhibitor Yes MSN06 Down Glutamate and glutamine metabolism 0.003766836 6 NaN SLC1A3;SLC1A5;SLC7A5
lapatinib Kinase inhibitor Yes MSN08 Down Glutamate and glutamine metabolism 0.045738032 27 NaN SLC1A5;SLC7A5
lapatinib Kinase inhibitor Yes MSN09 Down Glutamate and glutamine metabolism 0.047941794 25.5 NaN SLC1A5;SLC38A2
lapatinib Kinase inhibitor Yes MSN05 Down Glycolysis and Gluconeogenesis 0.026402563 24 NaN ENO1;LDHA;PGAM1
lapatinib Kinase inhibitor Yes MSN09 Down Glycolysis and Gluconeogenesis 0.003257229 6 NaN ENO1;LDHA;PGAM1;TPI1
lapatinib Kinase inhibitor Yes MSN01 Down G-protein coupled receptor signaling pathway 0.009153583 6 NaN GRK5;PDE4D;RGS4
lapatinib Kinase inhibitor Yes MSN01 Up Granulocyte macrophage colony-stimulating factor receptor signaling 0.045692235 18.5 NaN JUND
lapatinib Kinase inhibitor Yes MSN05 Up Granulocyte macrophage colony-stimulating factor receptor signaling 0.03480274 15 NaN JUND
lapatinib Kinase inhibitor Yes MSN06 Up Granulocyte macrophage colony-stimulating factor receptor signaling 0.040168784 15 NaN JUND
lapatinib Kinase inhibitor Yes MSN01 Up Granulocyte-colony stimulating factor receptor signaling 0.017209911 12 16 Up by cardiotoxic TKIs SOCS3;STAT3
lapatinib Kinase inhibitor Yes MSN05 Up Granulocyte-colony stimulating factor receptor signaling 0.010177876 8 16 Up by cardiotoxic TKIs SOCS3;STAT3
lapatinib Kinase inhibitor Yes MSN06 Up Granulocyte-colony stimulating factor receptor signaling 0.013432039 11 16 Up by cardiotoxic TKIs SOCS3;STAT3
lapatinib Kinase inhibitor Yes MSN09 Up Granulocyte-colony stimulating factor receptor signaling 0.011492797 7 16 Up by cardiotoxic TKIs SOCS3;STAT3
lapatinib Kinase inhibitor Yes MSN01 Down Growth differentiation factor receptor signaling 0.012425035 8 NaN GDF2;GDF6
lapatinib Kinase inhibitor Yes MSN08 Down Growth differentiation factor receptor signaling 0.017924062 14 NaN GDF2;GDF6
lapatinib Kinase inhibitor Yes MSN08 Up Hedgehog receptor signaling 0.006058183 6 NaN BOC;CDON;GAS1
lapatinib Kinase inhibitor Yes MSN09 Up Hedgehog receptor signaling 0.048315957 14 NaN BOC;CDON
lapatinib Kinase inhibitor Yes MSN08 Up Heme degradation to bilirubin 0.00118192 3.5 NaN BLVRB;HMOX1
lapatinib Kinase inhibitor Yes MSN09 Up Hepatocyte growth factor receptor signaling 0.000348126 2 NaN HGF;MET
lapatinib Kinase inhibitor Yes MSN01 Down Hepatocyte growth factor receptor signaling 0.043622809 20 NaN HGF
lapatinib Kinase inhibitor Yes MSN05 Down Hyaluronan-mediated motility receptor signaling 0.028405081 27.5 NaN HMMR
lapatinib Kinase inhibitor Yes MSN09 Down Hyaluronan-mediated motility receptor signaling 0.027434721 21 NaN HMMR
lapatinib Kinase inhibitor Yes MSN08 Down Inhibin receptor signaling 0.017924062 14 NaN INHBA;INHBE
lapatinib Kinase inhibitor Yes MSN05 Up Inhibition of amyloid aggregation, amyloid degradation and uptake 5.33E-06 2 NaN A2M;MME;PLAT
lapatinib Kinase inhibitor Yes MSN08 Up Inhibition of amyloid aggregation, amyloid degradation and uptake 0.00118192 3.5 NaN A2M;MME
lapatinib Kinase inhibitor Yes MSN06 Up Interferon alpha receptor signaling 0.010587731 8 NaN IRF9;STAT1
lapatinib Kinase inhibitor Yes MSN01 Up Interferon beta receptor signaling 0.010350023 11 NaN IFIT2;IRF9
lapatinib Kinase inhibitor Yes MSN05 Up Interferon beta receptor signaling 0.006076013 5 NaN IFIT2;IRF9
lapatinib Kinase inhibitor Yes MSN06 Up Interferon beta receptor signaling 0.008047841 7 NaN IFIT2;IRF9
lapatinib Kinase inhibitor Yes MSN05 Down Intracellular bridge assembly 2.27E-05 6 NaN INCENP;KIF23;NEK7
lapatinib Kinase inhibitor Yes MSN09 Down Intracellular bridge assembly 0.002210018 4.5 NaN KIF23;NEK7
lapatinib Kinase inhibitor Yes MSN08 Up Intrinsic apoptosis pathway 0.031008959 8 NaN BCL2L11;BMF
lapatinib Kinase inhibitor Yes MSN09 Up Intrinsic apoptosis pathway 0.027324073 10.5 NaN BCL2L11;BMF
lapatinib Kinase inhibitor Yes MSN01 Up JAK-STAT signaling pathway 0.040330112 16 NaN SOCS3;STAT3
lapatinib Kinase inhibitor Yes MSN05 Up JAK-STAT signaling pathway 0.024289095 11 NaN SOCS3;STAT3
lapatinib Kinase inhibitor Yes MSN06 Up JAK-STAT signaling pathway 0.000140829 2 NaN SOCS3;STAT1;STAT3;USP18
lapatinib Kinase inhibitor Yes MSN09 Up JAK-STAT signaling pathway 0.027324073 10.5 NaN SOCS3;STAT3
lapatinib Kinase inhibitor Yes MSN01 Down JAK-STAT signaling pathway 0.037023918 16 NaN SOCS2;STAT4
lapatinib Kinase inhibitor Yes MSN01 Up Leptin receptor signaling 0.003096266 5.5 5 Up by cardiotoxic TKIs SOCS3;STAT3
lapatinib Kinase inhibitor Yes MSN05 Up Leptin receptor signaling 0.001797512 3 5 Up by cardiotoxic TKIs SOCS3;STAT3
lapatinib Kinase inhibitor Yes MSN06 Up Leptin receptor signaling 0.002393952 5 5 Up by cardiotoxic TKIs SOCS3;STAT3
lapatinib Kinase inhibitor Yes MSN09 Up Leptin receptor signaling 0.002037514 5 5 Up by cardiotoxic TKIs SOCS3;STAT3
lapatinib Kinase inhibitor Yes MSN01 Up Lipogenesis 0.000532182 4 NaN ACLY;FASN
lapatinib Kinase inhibitor Yes MSN05 Up Lipogenesis 0.03480274 15 NaN FASN
lapatinib Kinase inhibitor Yes MSN06 Up Lipogenesis 0.040168784 15 NaN FASN
lapatinib Kinase inhibitor Yes MSN08 Up Lipogenesis 0.039650143 10 NaN FASN
lapatinib Kinase inhibitor Yes MSN09 Up Lipogenesis 0.037054838 12.5 NaN FASN
lapatinib Kinase inhibitor Yes MSN05 Down Metaphase to anaphase checkpoint 3.70E-06 3 NaN BUB1;BUB1B;CCNB2;CDC20;CENPE;MAD2L1;PTTG1;TTK
lapatinib Kinase inhibitor Yes MSN08 Down Metaphase to anaphase checkpoint 2.63E-05 3 NaN BUB1;BUB1B;CCNB2;CDC20;CENPE;PTTG1;TTK
lapatinib Kinase inhibitor Yes MSN09 Down Metaphase to anaphase checkpoint 0.013476514 15 NaN BUB1;CENPE;PTTG1;TTK
lapatinib Kinase inhibitor Yes MSN01 Down Methionine cycle 0.043622809 20 NaN BHMT
lapatinib Kinase inhibitor Yes MSN01 Up Microfibril scaffold organization 0.045692235 18.5 NaN MFAP2
lapatinib Kinase inhibitor Yes MSN06 Down Microfibril scaffold organization 0.049824365 25 NaN FBN1
lapatinib Kinase inhibitor Yes MSN05 Down Microtubule crosslinking and bundling 0.011186086 21 NaN MAP1B;MAP2
lapatinib Kinase inhibitor Yes MSN05 Down Mitotic chromosome condensation 0.000730004 12 NaN INCENP;NCAPG2;SMC4
lapatinib Kinase inhibitor Yes MSN05 Down Mitotic H3 phosphorylation and dephosphorylation 0.007599426 19 NaN CCNA2;INCENP
lapatinib Kinase inhibitor Yes MSN05 Down Mitotic spindle assembly 1.91E-05 5 NaN DLGAP5;NUSAP1;TACC3;TPX2;TTK
lapatinib Kinase inhibitor Yes MSN08 Down Mitotic spindle assembly 0.000295616 6 NaN DLGAP5;NUSAP1;TPX2;TTK
lapatinib Kinase inhibitor Yes MSN09 Down Mitotic spindle assembly 0.004767473 10.5 NaN DLGAP5;NUSAP1;TTK
lapatinib Kinase inhibitor Yes MSN05 Down Mitotic spindle disassembly 0.028405081 27.5 NaN CDK1
lapatinib Kinase inhibitor Yes MSN08 Down Mitotic spindle disassembly 0.026729005 18.5 NaN CDK1
lapatinib Kinase inhibitor Yes MSN09 Down Mitotic spindle disassembly 0.027434721 21 NaN CDK1
lapatinib Kinase inhibitor Yes MSN06 Down Muscarinic receptor signaling 0.008897083 7.5 NaN RGS4;RGS5
lapatinib Kinase inhibitor Yes MSN01 Down Natriuretic peptide receptor signaling 0.006853158 5 NaN NPPA;NPPB
lapatinib Kinase inhibitor Yes MSN05 Down Natriuretic peptide receptor signaling 0.000426104 9 NaN NPPA;NPPB;NPR3
lapatinib Kinase inhibitor Yes MSN06 Down Natriuretic peptide receptor signaling 0.008897083 7.5 NaN NPPA;NPPB
lapatinib Kinase inhibitor Yes MSN08 Down Natriuretic peptide receptor signaling 0.009947879 9 NaN NPPA;NPPB
lapatinib Kinase inhibitor Yes MSN09 Down Natriuretic peptide receptor signaling 0.010461076 13.5 NaN NPPA;NPPB
lapatinib Kinase inhibitor Yes MSN01 Up Necroptosis induction 0.023112209 15 NaN TNFRSF1A
lapatinib Kinase inhibitor Yes MSN06 Down Non-vesicular phospholipid transport 0.012249563 11.5 NaN PITPNM1;PLTP
lapatinib Kinase inhibitor Yes MSN05 Up Notch receptor signaling 0.047356994 18 NaN DLK1;MIB2
lapatinib Kinase inhibitor Yes MSN05 Down Osteonectin receptor signaling 0.004646709 16.5 NaN SPARC;SPOCK1
lapatinib Kinase inhibitor Yes MSN06 Down Osteonectin receptor signaling 0.003680135 5 NaN SPARC;SPOCK1
lapatinib Kinase inhibitor Yes MSN09 Down Osteonectin receptor signaling 0.004339881 7.5 NaN SPARC;SPOCK1
lapatinib Kinase inhibitor Yes MSN01 Down Osteopontin receptor signaling 0.022053634 11.5 NaN SPP1
lapatinib Kinase inhibitor Yes MSN05 Down Osteopontin receptor signaling 0.028405081 27.5 NaN SPP1
lapatinib Kinase inhibitor Yes MSN08 Down Osteopontin receptor signaling 0.026729005 18.5 NaN SPP1
lapatinib Kinase inhibitor Yes MSN09 Down Osteopontin receptor signaling 0.027434721 21 NaN SPP1
lapatinib Kinase inhibitor Yes MSN06 Down Perlecan synthesis 0.025229358 17.5 NaN HSPG2
lapatinib Kinase inhibitor Yes MSN06 Down Platelet-derived growth factor receptor signaling 0.030019151 20 14 Down by cardiotoxic TKIs RGS5;TNK2
lapatinib Kinase inhibitor Yes MSN05 Up Potassium transmembrane transport 0.008219515 6.5 7 Up by cardiotoxic TKIs ABCC9;FXYD1;SLC12A6
lapatinib Kinase inhibitor Yes MSN06 Up Potassium transmembrane transport 0.012182779 9.5 7 Up by cardiotoxic TKIs ABCC9;ATP1A3;KCNQ1
lapatinib Kinase inhibitor Yes MSN06 Down Proteasomal regulatory particle organization 0.012249563 11.5 NaN PSMC4;PSMD14
lapatinib Kinase inhibitor Yes MSN05 Down Pyrimidine synthesis and salvage 0.020110197 23 NaN TK1;TYMS
lapatinib Kinase inhibitor Yes MSN08 Down Pyrimidine synthesis and salvage 0.017924062 14 NaN TK1;TYMS
lapatinib Kinase inhibitor Yes MSN01 Down Removal of caspase inhibition 0.043622809 20 NaN XAF1
lapatinib Kinase inhibitor Yes MSN08 Down Retinol metabolism 0.0044314 7 NaN ALDH1A1;ALDH1A3;RDH10
lapatinib Kinase inhibitor Yes MSN09 Down Retinol metabolism 0.004767473 10.5 NaN ALDH1A1;ALDH1A3;RPE65
lapatinib Kinase inhibitor Yes MSN09 Up Semaphorin signaling 0.025210977 9 NaN NRP2;SEMA6A;SEMA6D
lapatinib Kinase inhibitor Yes MSN01 Down Semaphorin signaling 0.038375695 17 NaN PLXNA2;PLXNC1;SEMA5A
lapatinib Kinase inhibitor Yes MSN01 Down Serine and glycine metabolism 6.75E-05 1 NaN PHGDH;PSAT1;SHMT2;SLC1A5
lapatinib Kinase inhibitor Yes MSN05 Up Serotonin inactivation 0.03480274 15 NaN MAOA
lapatinib Kinase inhibitor Yes MSN08 Up Serotonin inactivation 0.039650143 10 NaN MAOA
lapatinib Kinase inhibitor Yes MSN01 Down Serotonin inactivation 0.043622809 20 NaN MAOA
lapatinib Kinase inhibitor Yes MSN06 Down Serotonin inactivation 0.049824365 25 NaN MAOA
lapatinib Kinase inhibitor Yes MSN05 Down Sister chromatid attachment to mitotic spindle 0.000804414 13 NaN NUF2;TACC3
lapatinib Kinase inhibitor Yes MSN05 Down Sister chromatid segregation 0.000426104 9 NaN ESPL1;PTTG1;TOP2A
lapatinib Kinase inhibitor Yes MSN08 Down Sister chromatid segregation 0.009947879 9 NaN PTTG1;TOP2A
lapatinib Kinase inhibitor Yes MSN01 Down Thin myofilament organization 0.009455468 7 21 Down by cardiotoxic TKIs TPM2;TPM4
lapatinib Kinase inhibitor Yes MSN06 Down Thin myofilament organization 0.012249563 11.5 21 Down by cardiotoxic TKIs ACTA1;TPM2
lapatinib Kinase inhibitor Yes MSN09 Down Thin myofilament organization 0.014381727 16.5 21 Down by cardiotoxic TKIs ACTA1;TNNI3
lapatinib Kinase inhibitor Yes MSN09 Down Thrombospondin receptor signaling 0.004339881 7.5 NaN CD47;THBS4
lapatinib Kinase inhibitor Yes MSN06 Down Tight junction organization 0.010141758 9 NaN CGNL1;CLDN6;CRB2;MYLK
lapatinib Kinase inhibitor Yes MSN08 Down Tight junction organization 0.012342235 11 NaN CLDN1;CLDN6;CRB2;MYLK
lapatinib Kinase inhibitor Yes MSN01 Down Tropoelastin synthesis 0.022053634 11.5 NaN ELN
lapatinib Kinase inhibitor Yes MSN05 Down Tropoelastin synthesis 0.028405081 27.5 NaN ELN
lapatinib Kinase inhibitor Yes MSN06 Down Tropoelastin synthesis 0.025229358 17.5 NaN ELN
lapatinib Kinase inhibitor Yes MSN08 Down Tropoelastin synthesis 0.026729005 18.5 NaN ELN
lapatinib Kinase inhibitor Yes MSN01 Up Vasoactive intestinal peptide receptor signaling 0.045692235 18.5 NaN VIPR2
lapatinib Kinase inhibitor Yes MSN05 Up Vasoactive intestinal peptide receptor signaling 0.03480274 15 NaN VIPR1
lapatinib Kinase inhibitor Yes MSN09 Up Vasoactive intestinal peptide receptor signaling 0.037054838 12.5 NaN VIPR1
lapatinib Kinase inhibitor Yes MSN01 Down Versican receptor signaling 0.043622809 20 NaN VCAN
lapatinib Kinase inhibitor Yes MSN06 Down Versican receptor signaling 0.049824365 25 NaN VCAN
lapatinib Kinase inhibitor Yes MSN01 Down Versican synthesis 0.022053634 11.5 NaN VCAN
lapatinib Kinase inhibitor Yes MSN05 Down Versican synthesis 0.028405081 27.5 NaN VCAN
lapatinib Kinase inhibitor Yes MSN06 Down Versican synthesis 0.025229358 17.5 NaN VCAN
lapatinib Kinase inhibitor Yes MSN08 Down Versican synthesis 0.026729005 18.5 NaN VCAN
lapatinib Kinase inhibitor Yes MSN09 Down Versican synthesis 0.027434721 21 NaN VCAN
lapatinib Kinase inhibitor Yes MSN06 Up WNT-Beta-catenin signaling pathway 0.040737529 17 NaN CTHRC1;FZD7;SFRP2;WNT2
lapatinib Kinase inhibitor Yes MSN09 Up WNT-Beta-catenin signaling pathway 0.001211189 4 NaN AMER1;CTHRC1;FZD1;SFRP2;SFRP4;WNT2
lapatinib Kinase inhibitor Yes MSN01 Up Z-disc organization 0.005468709 9 NaN CSRP3;DES;TCAP
lapatinib Kinase inhibitor Yes MSN05 Up Z-disc organization 0.031304625 12 NaN DES;TCAP
lapatinib Kinase inhibitor Yes MSN01 Down Actin filament severing and depolymerization 0.032195057 15 NaN LIMA1;TAGLN2
lapatinib Kinase inhibitor Yes MSN09 Down Actin filament severing and depolymerization 0.047941794 25.5 NaN CFL2;TAGLN2
lapatinib Kinase inhibitor Yes MSN01 Down Adrenergic receptor signaling 0.018950674 9 8 Down by cardiotoxic TKIs GRK5;PDE4D;RGS4
lapatinib Kinase inhibitor Yes MSN06 Up Aggrecan synthesis 0.020289344 13 NaN ACAN
lapatinib Kinase inhibitor Yes MSN01 Down Aggrecan synthesis 0.022053634 11.5 NaN ACAN
lapatinib Kinase inhibitor Yes MSN08 Down Aggrecan synthesis 0.026729005 18.5 NaN ACAN
lapatinib Kinase inhibitor Yes MSN05 Up Albumin mediated blood protein transport 0.017554693 9.5 NaN ALB
lapatinib Kinase inhibitor Yes MSN01 Up Alternative complement pathway 0.005081819 7.5 NaN C3;CFH
lapatinib Kinase inhibitor Yes MSN01 Up Antigen presentation via MHC class I molecules 0.02118776 14 NaN HLA-B;HLA-C
lapatinib Kinase inhibitor Yes MSN08 Down Aspartate and arginine metabolism 0.02780993 22.5 NaN ARG2;DDAH1
lapatinib Kinase inhibitor Yes MSN06 Down Axonal intermediate filament dynamics 0.012249563 11.5 NaN NEFM;NES
lapatinib Kinase inhibitor Yes MSN08 Down Axonal intermediate filament dynamics 0.013682625 12 NaN NEFM;NES
lapatinib Kinase inhibitor Yes MSN09 Down Axonal intermediate filament dynamics 0.014381727 16.5 NaN NEFM;NES
lapatinib Kinase inhibitor Yes MSN05 Down Biglycan synthesis 0.028405081 27.5 18 Down by cardiotoxic TKIs BGN
lapatinib Kinase inhibitor Yes MSN06 Down Biglycan synthesis 0.025229358 17.5 18 Down by cardiotoxic TKIs BGN
lapatinib Kinase inhibitor Yes MSN08 Down Biglycan synthesis 0.026729005 18.5 18 Down by cardiotoxic TKIs BGN
lapatinib Kinase inhibitor Yes MSN09 Down Biglycan synthesis 0.027434721 21 18 Down by cardiotoxic TKIs BGN
lapatinib Kinase inhibitor Yes MSN05 Up Calcitonin receptor signaling 0.03480274 15 NaN RAMP1
lapatinib Kinase inhibitor Yes MSN08 Up Calcitonin receptor signaling 0.039650143 10 NaN RAMP1
lapatinib Kinase inhibitor Yes MSN06 Up Cardiomyocyte repolarization during action potential and hyperpolarization 0.002543158 6 NaN KCNA1;KCNIP2;KCNQ1
lapatinib Kinase inhibitor Yes MSN06 Down CD44-Mediated leukocyte rolling 0.049824365 25 NaN CD44
lapatinib Kinase inhibitor Yes MSN01 Down Cellular cholesterol uptake and efflux 0.0025731 3.5 23 Down by cardiotoxic TKIs ABCA1;ABCG1;ARL4C
lapatinib Kinase inhibitor Yes MSN06 Down Cellular cholesterol uptake and efflux 0.041189931 22 23 Down by cardiotoxic TKIs ABCA1;ABCG1
lapatinib Kinase inhibitor Yes MSN05 Down Centrosome maturation 0.004127977 15 NaN AURKA;PLK1;TPX2
lapatinib Kinase inhibitor Yes MSN08 Down Centrosome maturation 0.039383166 25.5 NaN PLK1;TPX2
lapatinib Kinase inhibitor Yes MSN05 Down Centrosome organization 0.012534315 22 NaN ASPM;NEK2;NEK7;PAX6;TACC3;WDR62
lapatinib Kinase inhibitor Yes MSN05 Down Centrosome separation 1.67E-11 1 NaN AURKA;CCNB1;CDK1;ESPL1;KIF11;NEK2;NEK6;SPAG5
lapatinib Kinase inhibitor Yes MSN08 Down Centrosome separation 2.98E-06 1 NaN CCNB1;CDK1;KIF11;NEK6;SPAG5
lapatinib Kinase inhibitor Yes MSN06 Down Chaperone-mediated autophagy 0.049824365 25 NaN HSPA8
lapatinib Kinase inhibitor Yes MSN01 Up Cholesterol synthesis 2.69E-21 1 22 Up by cardiotoxic TKIs CYP51A1;DHCR24;DHCR7;EBP;FDFT1;FDPS;HMGCR;HMGCS1;LSS;MSMO1;MVD;MVK;NSDHL;SC5D;SQLE
lapatinib Kinase inhibitor Yes MSN05 Up Cholesterol synthesis 3.52E-13 1 22 Up by cardiotoxic TKIs CYP51A1;DHCR24;DHCR7;FDFT1;FDPS;HMGCR;HMGCS1;LSS;MVD;SQLE
lapatinib Kinase inhibitor Yes MSN06 Up Cholesterol synthesis 4.69E-20 1 22 Up by cardiotoxic TKIs CYP51A1;DHCR24;DHCR7;EBP;FDFT1;FDPS;HMGCR;HMGCS1;LSS;MSMO1;MVD;MVK;NSDHL;SQLE
lapatinib Kinase inhibitor Yes MSN08 Up Cholesterol synthesis 2.34E-14 1 22 Up by cardiotoxic TKIs CYP51A1;DHCR24;DHCR7;FDFT1;FDPS;HMGCR;HMGCS1;LSS;MSMO1;MVD;SQLE
lapatinib Kinase inhibitor Yes MSN09 Up Cholesterol synthesis 1.09E-14 1 22 Up by cardiotoxic TKIs CYP51A1;DHCR24;DHCR7;FDFT1;FDPS;HMGCR;HMGCS1;LSS;MSMO1;MVD;SQLE
lapatinib Kinase inhibitor Yes MSN01 Up Cholesterol-sensitive control of SREBP activation 0.000231836 2 15 Up by cardiotoxic TKIs INSIG1;SREBF1;SREBF2
lapatinib Kinase inhibitor Yes MSN05 Up Cholesterol-sensitive control of SREBP activation 0.004390599 4 15 Up by cardiotoxic TKIs INSIG1;SREBF1
lapatinib Kinase inhibitor Yes MSN06 Up Cholesterol-sensitive control of SREBP activation 0.000157602 3 15 Up by cardiotoxic TKIs INSIG1;SREBF1;SREBF2
lapatinib Kinase inhibitor Yes MSN08 Up Cholesterol-sensitive control of SREBP activation 0.005678798 5 15 Up by cardiotoxic TKIs INSIG1;SREBF1
lapatinib Kinase inhibitor Yes MSN09 Up Cholesterol-sensitive control of SREBP activation 0.004969189 6 15 Up by cardiotoxic TKIs INSIG1;SREBF1
lapatinib Kinase inhibitor Yes MSN01 Down Classical complement pathway 0.000347383 2 NaN C1QA;C1QB;C1QC
lapatinib Kinase inhibitor Yes MSN05 Down Collagen fiber crosslinking 0.007599426 19 NaN LOX;LOXL1
lapatinib Kinase inhibitor Yes MSN09 Down Collagen fiber crosslinking 0.000196309 1.5 NaN LOX;LOXL1;PLOD1
lapatinib Kinase inhibitor Yes MSN01 Up Collagen fibril organization by fibril-associated bridges 0.007506811 10 NaN COL14A1;COL9A3
lapatinib Kinase inhibitor Yes MSN05 Down Collagen fibril organization by fibril-associated bridges 0.000426104 9 NaN COL12A1;COL9A1;COL9A2
lapatinib Kinase inhibitor Yes MSN08 Down Collagen fibril organization by fibril-associated bridges 0.009947879 9 NaN COL9A1;COL9A2
lapatinib Kinase inhibitor Yes MSN09 Down Collagen fibril organization by fibril-associated bridges 0.010461076 13.5 NaN COL9A1;COL9A2
lapatinib Kinase inhibitor Yes MSN05 Down Contractile ring constriction 0.000217634 7 NaN ANLN;ECT2;MYLK
lapatinib Kinase inhibitor Yes MSN06 Down Contractile ring constriction 0.000153057 2 NaN ANLN;MYH14;MYLK
lapatinib Kinase inhibitor Yes MSN08 Down Contractile ring constriction 0.000181696 5 NaN ANLN;MYH14;MYLK
lapatinib Kinase inhibitor Yes MSN09 Down Contractile ring constriction 0.000196309 1.5 NaN ANLN;MYH14;MYLK
lapatinib Kinase inhibitor Yes MSN05 Up Decorin synthesis 0.017554693 9.5 NaN DCN
lapatinib Kinase inhibitor Yes MSN08 Up Decorin synthesis 0.0200247 7 NaN DCN
lapatinib Kinase inhibitor Yes MSN09 Up Decorin synthesis 0.018701482 8 NaN DCN
lapatinib Kinase inhibitor Yes MSN01 Up Desaturation of fatty acids 0.000398781 3 11 Up by cardiotoxic TKIs FADS1;FADS2;SCD
lapatinib Kinase inhibitor Yes MSN06 Up Desaturation of fatty acids 0.000271672 4 11 Up by cardiotoxic TKIs FADS1;FADS2;SCD
lapatinib Kinase inhibitor Yes MSN05 Down DNA replication elongation 0.007599426 19 NaN MCM5;PCNA
lapatinib Kinase inhibitor Yes MSN09 Down DNA replication elongation 0.007102263 12 NaN MCM5;PCNA
lapatinib Kinase inhibitor Yes MSN05 Down DNA replication initiation 4.32E-06 4 NaN CDC45;CDC6;GINS1;GINS2;MCM10;MCM5;MCM6
lapatinib Kinase inhibitor Yes MSN08 Down DNA replication initiation 4.00E-05 4 NaN CDC45;CDC6;GINS1;MCM10;MCM5;MCM6
lapatinib Kinase inhibitor Yes MSN09 Down DNA replication initiation 0.004457113 9 NaN CDC6;GINS2;MCM5;MCM6
lapatinib Kinase inhibitor Yes MSN01 Up Eicosanoid metabolism 0.045839398 21 NaN CYP2J2;PLA2G2A
lapatinib Kinase inhibitor Yes MSN05 Down Elastin cross-linking and assembly 0.002367819 14 NaN LOX;LOXL1
lapatinib Kinase inhibitor Yes MSN09 Down Elastin cross-linking and assembly 0.002210018 4.5 NaN LOX;LOXL1
lapatinib Kinase inhibitor Yes MSN01 Up Endogenous control of complement activity 0.005081819 7.5 NaN CFH;CFI
lapatinib Kinase inhibitor Yes MSN06 Down Epithelial intermediate filament dynamics 0.016062742 14 NaN KRT7;KRT8
lapatinib Kinase inhibitor Yes MSN05 Down Equatorial RhoA activation 0.004646709 16.5 NaN ECT2;KIF23
lapatinib Kinase inhibitor Yes MSN08 Up ER unfolded protein response pathway 0.000411975 2 NaN DDIT3;HERPUD1;PPP1R15A
isoprenaline Sympathomimetic No MSN01 Up Actin filament bundling and crosslinking 0.004924637 7.5 NaN ACTN2;SYNPO;TAGLN;USH1C
isoprenaline Sympathomimetic No MSN08 Up Adenylyl cyclase signaling pathway 0.00647259 8 NaN PDE3A;PDE4D;RAPGEF4
isoprenaline Sympathomimetic No MSN01 Up Adrenergic receptor signaling 0.004924637 7.5 NaN GNB3;GRK5;PDE4D;RGS4
isoprenaline Sympathomimetic No MSN05 Up Adrenergic receptor signaling 0.026915049 12 NaN PDE4D;RASD1;RGS16
isoprenaline Sympathomimetic No MSN08 Up Adrenergic receptor signaling 0.000209285 4 NaN GRK5;PDE4D;RAPGEF4;RASD1;RGS16
isoprenaline Sympathomimetic No MSN09 Up Adrenergic receptor signaling 0.003732001 7 NaN GNB3;GRK5;PDE4D;RASD1
isoprenaline Sympathomimetic No MSN01 Up Aggrecan synthesis 0.027081863 19 NaN ACAN
isoprenaline Sympathomimetic No MSN09 Up Aggrecan synthesis 0.025052929 13.5 NaN ACAN
isoprenaline Sympathomimetic No MSN08 Up Albumin mediated blood protein transport 0.021700776 15 NaN ALB
isoprenaline Sympathomimetic No MSN01 Down Albumin mediated blood protein transport 0.018348624 10 NaN ALB
isoprenaline Sympathomimetic No MSN09 Down Albumin mediated blood protein transport 0.019318984 6.5 NaN ALB
isoprenaline Sympathomimetic No MSN01 Down Alternative complement pathway 0.003230669 4 NaN C1S;CFH
isoprenaline Sympathomimetic No MSN01 Up Amyloid plaque organization 0.034215437 21 NaN COL25A1;HSPB6
isoprenaline Sympathomimetic No MSN09 Up Amyloid plaque organization 0.029631379 16 NaN COL25A1;HSPB6
isoprenaline Sympathomimetic No MSN05 Up Androgen receptor signaling 0.049824365 19 NaN AR
isoprenaline Sympathomimetic No MSN08 Up Androgen receptor signaling 0.042932502 17 NaN AR
isoprenaline Sympathomimetic No MSN09 Up Androgen receptor signaling 0.049480363 24 NaN AR
isoprenaline Sympathomimetic No MSN01 Down Antigen presentation via MHC class I molecules 0.01368451 7 NaN HLA-B;HLA-C
isoprenaline Sympathomimetic No MSN05 Down Antigen presentation via MHC class I molecules 0.000846027 2 NaN HLA-A;HLA-B;HLA-C
isoprenaline Sympathomimetic No MSN08 Down Antigen presentation via MHC class I molecules 0.001270083 3.5 NaN HLA-A;HLA-B;HLA-C
isoprenaline Sympathomimetic No MSN09 Down Antigen presentation via MHC class I molecules 0.015095412 2 NaN HLA-B;HLA-C
isoprenaline Sympathomimetic No MSN08 Down Axonal intermediate filament dynamics 0.010198353 8 NaN NEFH;NES
isoprenaline Sympathomimetic No MSN01 Down Basement membrane assembly and organization 0.01368451 7 NaN COL4A4;COL8A2
isoprenaline Sympathomimetic No MSN05 Down Basement membrane assembly and organization 0.016025171 6 NaN COL4A4;COL8A2
isoprenaline Sympathomimetic No MSN08 Down Basement membrane assembly and organization 0.02088458 10.5 NaN COL4A4;COL8A2
isoprenaline Sympathomimetic No MSN09 Down Basement membrane assembly and organization 0.015095412 2 NaN COL4A4;COL8A2
isoprenaline Sympathomimetic No MSN05 Down Biglycan synthesis 0.019936486 9 NaN BGN
isoprenaline Sympathomimetic No MSN08 Down Biglycan synthesis 0.02293578 13 NaN BGN
isoprenaline Sympathomimetic No MSN09 Down Biglycan synthesis 0.019318984 6.5 NaN BGN
isoprenaline Sympathomimetic No MSN09 Up Calcitonin receptor signaling 0.049480363 24 NaN RAMP1
isoprenaline Sympathomimetic No MSN01 Up CCN intercellular signaling protein family receptor signaling 0.00018891 3 NaN CTGF;CYR61;NOV
isoprenaline Sympathomimetic No MSN05 Up CCN intercellular signaling protein family receptor signaling 0.000153057 3 NaN CTGF;CYR61;WISP1
isoprenaline Sympathomimetic No MSN08 Up CCN intercellular signaling protein family receptor signaling 0.004491781 7 NaN CYR61;WISP1
isoprenaline Sympathomimetic No MSN09 Up CCN intercellular signaling protein family receptor signaling 0.005949437 8 NaN CTGF;CYR61
isoprenaline Sympathomimetic No MSN05 Up CD44-Mediated leukocyte rolling 0.049824365 19 NaN CD44
isoprenaline Sympathomimetic No MSN09 Up CD44-Mediated leukocyte rolling 0.049480363 24 NaN CD44
isoprenaline Sympathomimetic No MSN05 Up Cellular fatty acid uptake 0.049824365 19 NaN CD36
isoprenaline Sympathomimetic No MSN08 Up Cellular fatty acid uptake 0.042932502 17 NaN CD36
isoprenaline Sympathomimetic No MSN09 Up Cellular fatty acid uptake 0.049480363 24 NaN CD36
isoprenaline Sympathomimetic No MSN05 Up Cellular iron uptake and export 0.041189931 15.5 NaN RASD1;TFRC
isoprenaline Sympathomimetic No MSN08 Up Cellular iron uptake and export 0.002457614 6 NaN RASD1;SLC40A1;TFRC
isoprenaline Sympathomimetic No MSN09 Up Cellular iron uptake and export 0.04066719 19.5 NaN RASD1;TFRC
isoprenaline Sympathomimetic No MSN08 Down Centrosome maturation 0.02972276 16 NaN PLK1;TPX2
isoprenaline Sympathomimetic No MSN01 Up Centrosome organization 0.010070134 10 NaN ASPM;GRK5;HOOK2;PAX6;PLK3;WDR62
isoprenaline Sympathomimetic No MSN08 Down Centrosome separation 0.02088458 10.5 NaN CCNB1;NEK6
isoprenaline Sympathomimetic No MSN08 Down Chaperone-mediated autophagy 0.045347487 22.5 NaN HSPA8
isoprenaline Sympathomimetic No MSN01 Up Cholesterol synthesis 9.01E-10 1 NaN CYP51A1;DHCR24;DHCR7;HMGCR;HMGCS1;MSMO1;MVD;NSDHL;SQLE
isoprenaline Sympathomimetic No MSN05 Up Cholesterol synthesis 1.04E-18 1 NaN CYP51A1;DHCR24;DHCR7;EBP;FDFT1;FDPS;HMGCR;HMGCS1;LSS;MSMO1;MVD;MVK;NSDHL;SQLE
isoprenaline Sympathomimetic No MSN08 Up Cholesterol synthesis 5.69E-14 1 NaN CYP51A1;DHCR24;DHCR7;EBP;FDFT1;FDPS;HMGCR;HMGCS1;MSMO1;MVD;SQLE
isoprenaline Sympathomimetic No MSN09 Up Cholesterol synthesis 9.46E-19 1 NaN CYP51A1;DHCR24;DHCR7;EBP;FDFT1;FDPS;HMGCR;HMGCS1;LSS;MSMO1;MVD;MVK;NSDHL;SQLE
isoprenaline Sympathomimetic No MSN08 Up Cholesterol-sensitive control of SREBP activation 0.006641482 10 NaN INSIG1;SREBF1
isoprenaline Sympathomimetic No MSN09 Up Cholesterol-sensitive control of SREBP activation 0.008777038 9.5 NaN INSIG1;SREBF1
isoprenaline Sympathomimetic No MSN01 Down Classical complement pathway 0.006621825 5 NaN C1R;C1S
isoprenaline Sympathomimetic No MSN09 Up Coagulation cascade 0.034978854 18 NaN F2RL1;TFPI
isoprenaline Sympathomimetic No MSN01 Up Collagen fibril organization by fibril-associated bridges 0.010202989 12 NaN COL12A1;COL14A1
isoprenaline Sympathomimetic No MSN05 Up Collagen fibril organization by fibril-associated bridges 0.000300395 4 NaN COL12A1;COL14A1;COL19A1
isoprenaline Sympathomimetic No MSN08 Up Collagen fibril organization by fibril-associated bridges 0.000192378 3 NaN COL12A1;COL14A1;COL19A1
isoprenaline Sympathomimetic No MSN09 Up Collagen fibril organization by fibril-associated bridges 0.000294233 2 NaN COL12A1;COL14A1;COL19A1
isoprenaline Sympathomimetic No MSN05 Down Collagen fibril organization by fibril-associated bridges 0.000149607 1 NaN COL9A1;COL9A2;COL9A3
isoprenaline Sympathomimetic No MSN08 Down Contractile ring constriction 0.00500617 5.5 NaN ANLN;MYH14
isoprenaline Sympathomimetic No MSN01 Down Decorin synthesis 0.018348624 10 NaN DCN
isoprenaline Sympathomimetic No MSN01 Up Desaturation of fatty acids 0.014030212 14 NaN FADS2;SCD
isoprenaline Sympathomimetic No MSN05 Up Desaturation of fatty acids 0.000515881 5 NaN FADS1;FADS2;SCD
isoprenaline Sympathomimetic No MSN08 Up Desaturation of fatty acids 0.009165569 13 NaN FADS1;SCD
isoprenaline Sympathomimetic No MSN09 Up Desaturation of fatty acids 0.000505368 3 NaN FADS1;FADS2;SCD
isoprenaline Sympathomimetic No MSN05 Down Drug and toxin export via membrane transport proteins 0.049098649 15 NaN ABCA1;ABCC3
isoprenaline Sympathomimetic No MSN01 Up Epithelial intermediate filament dynamics 0.018375096 16 NaN KRT7;KRT8
isoprenaline Sympathomimetic No MSN05 Down Epithelial intermediate filament dynamics 0.010236386 4 NaN KRT19;KRT7
isoprenaline Sympathomimetic No MSN08 Down Epithelial intermediate filament dynamics 0.000613265 2 NaN KRT19;KRT7;TCHH
isoprenaline Sympathomimetic No MSN08 Down Mitotic spindle assembly 0.000164225 1 NaN DLGAP5;NUSAP1;TACC3;TPX2
isoprenaline Sympathomimetic No MSN09 Down Mitotic spindle assembly 0.025189984 9 NaN DLGAP5;NUSAP1
isoprenaline Sympathomimetic No MSN01 Up Mitotic spindle disassembly 0.027081863 19 NaN CDK1
isoprenaline Sympathomimetic No MSN01 Up Muscarinic receptor signaling 0.010202989 12 NaN CHRM4;RGS4
isoprenaline Sympathomimetic No MSN05 Up Muscarinic receptor signaling 0.008897083 8.5 NaN CHRM1;CHRM4
isoprenaline Sympathomimetic No MSN08 Up Muscarinic receptor signaling 0.006641482 10 NaN CHRM1;CHRM4
isoprenaline Sympathomimetic No MSN09 Up Muscarinic receptor signaling 0.008777038 9.5 NaN CHRM1;CHRM4
isoprenaline Sympathomimetic No MSN01 Up Natriuretic peptide receptor signaling 0.010202989 12 NaN NPPA;NPPB
isoprenaline Sympathomimetic No MSN05 Up Natriuretic peptide receptor signaling 0.008897083 8.5 NaN NPPA;NPPB
isoprenaline Sympathomimetic No MSN08 Down Natriuretic peptide receptor signaling 0.007395936 7 NaN NPPA;NPPB
isoprenaline Sympathomimetic No MSN05 Down Neuregulin receptor signaling 0.019331602 7 NaN ERBB3;NRG1
isoprenaline Sympathomimetic No MSN01 Down NOD-like receptor signaling 0.02287923 12 NaN NLRC5;NOD1
isoprenaline Sympathomimetic No MSN01 Up Osteopontin receptor signaling 0.027081863 19 NaN SPP1
isoprenaline Sympathomimetic No MSN09 Up Perlecan synthesis 0.025052929 13.5 NaN HSPG2
isoprenaline Sympathomimetic No MSN05 Up Platelet-derived growth factor receptor signaling 0.030019151 13.5 NaN PDGFRA;PDGFRB
isoprenaline Sympathomimetic No MSN09 Up Platelet-derived growth factor receptor signaling 0.029631379 16 NaN PDGFRA;PDGFRB
isoprenaline Sympathomimetic No MSN08 Up Prostaglandin E2 receptor signaling 0.006641482 10 NaN PTGER3;RAPGEF4
isoprenaline Sympathomimetic No MSN01 Up Retinol metabolism 0.046834922 23 NaN ALDH1A1;ALDH1A3
isoprenaline Sympathomimetic No MSN05 Up Retinol metabolism 0.041189931 15.5 NaN DHRS3;RLBP1
isoprenaline Sympathomimetic No MSN09 Up Retinol metabolism 0.04066719 19.5 NaN ALDH1A1;ALDH1A3
isoprenaline Sympathomimetic No MSN08 Down Semaphorin signaling 0.042327049 19.5 NaN CRMP1;DPYSL4;PLXNA2
isoprenaline Sympathomimetic No MSN09 Down Semaphorin signaling 0.027413967 10 NaN CRMP1;DPYSL4;NRP2
isoprenaline Sympathomimetic No MSN05 Up Serine and glycine metabolism 0.030019151 13.5 NaN PHGDH;SLC1A4
isoprenaline Sympathomimetic No MSN08 Up Serine and glycine metabolism 0.001464159 5 NaN PHGDH;SHMT2;SLC1A4
isoprenaline Sympathomimetic No MSN09 Up Serine and glycine metabolism 0.029631379 16 NaN PHGDH;SLC1A4
isoprenaline Sympathomimetic No MSN01 Down Serine and glycine metabolism 0.000901167 2 NaN PHGDH;SHMT2;SLC1A5
isoprenaline Sympathomimetic No MSN09 Down Serine and glycine metabolism 0.018217405 4 NaN SHMT2;SLC1A5
isoprenaline Sympathomimetic No MSN09 Up Serotonin inactivation 0.049480363 24 NaN MAOA
isoprenaline Sympathomimetic No MSN05 Down Serotonin inactivation 0.039477231 13 NaN MAOA
isoprenaline Sympathomimetic No MSN08 Down Sister chromatid attachment to mitotic spindle 0.045347487 22.5 NaN TACC3
isoprenaline Sympathomimetic No MSN05 Down Sodium transmembrane transport 0.025353723 11 NaN ATP1A2;FXYD5;SCN1A
isoprenaline Sympathomimetic No MSN08 Down Sodium transmembrane transport 0.036265819 18 NaN ATP1A2;FXYD5;SCN1A
isoprenaline Sympathomimetic No MSN01 Up Thin myofilament organization 1.73E-05 2 NaN ACTA1;TNNI3;TPM2;TPM4
isoprenaline Sympathomimetic No MSN05 Up Thrombospondin receptor signaling 0.003680135 7 NaN THBS1;THBS2
isoprenaline Sympathomimetic No MSN05 Down Tropoelastin synthesis 0.019936486 9 NaN ELN
isoprenaline Sympathomimetic No MSN08 Down Tropoelastin synthesis 0.02293578 13 NaN ELN
isoprenaline Sympathomimetic No MSN09 Down Tropoelastin synthesis 0.019318984 6.5 NaN ELN
isoprenaline Sympathomimetic No MSN09 Up Vascular endothelial growth factor receptor signaling 0.012085707 11 NaN FLT1;KDR
isoprenaline Sympathomimetic No MSN01 Down Versican receptor signaling 0.036362165 14 NaN VCAN
isoprenaline Sympathomimetic No MSN05 Down Versican receptor signaling 0.039477231 13 NaN VCAN
isoprenaline Sympathomimetic No MSN08 Down Versican receptor signaling 0.045347487 22.5 NaN VCAN
isoprenaline Sympathomimetic No MSN09 Down Versican receptor signaling 0.038266416 11 NaN VCAN
isoprenaline Sympathomimetic No MSN01 Down Versican synthesis 0.018348624 10 NaN VCAN
isoprenaline Sympathomimetic No MSN05 Down Versican synthesis 0.019936486 9 NaN VCAN
isoprenaline Sympathomimetic No MSN08 Down Versican synthesis 0.02293578 13 NaN VCAN
isoprenaline Sympathomimetic No MSN09 Down Versican synthesis 0.019318984 6.5 NaN VCAN
isoprenaline Sympathomimetic No MSN01 Up Extracellular matrix breakdown and membrane shedding by adamalysins 0.003652082 6 NaN ADAM19;ADAMTS14;ADAMTS8;ADAMTS9
isoprenaline Sympathomimetic No MSN05 Up Extracellular matrix breakdown and membrane shedding by adamalysins 0.021737239 11 NaN ADAM19;ADAMTS14;ADAMTS8
isoprenaline Sympathomimetic No MSN08 Up Extracellular matrix breakdown and membrane shedding by adamalysins 0.014592845 14 NaN ADAMTS14;ADAMTS15;ADAMTS8
isoprenaline Sympathomimetic No MSN01 Down Extracellular matrix breakdown and membrane shedding by adamalysins 6.34E-05 1 NaN ADAM33;ADAMTS10;ADAMTS2;ADAMTS5;ADAMTS6
isoprenaline Sympathomimetic No MSN09 Down Extracellular matrix breakdown by cathepsins 0.015095412 2 NaN CTSF;CTSV
isoprenaline Sympathomimetic No MSN05 Down Extracellular matrix breakdown by matrix metalloproteases 0.012989342 5 NaN MMP1;MMP2
isoprenaline Sympathomimetic No MSN01 Up Fatty acid elongation 0.023206981 17 NaN ELOVL5;ELOVL6
isoprenaline Sympathomimetic No MSN09 Up Fatty acid elongation 0.020044392 12 NaN ELOVL5;ELOVL6
isoprenaline Sympathomimetic No MSN05 Up Fibrillar collagen core structure organization 7.39E-05 2 NaN COL11A2;COL1A2;COL2A1;COL3A1
isoprenaline Sympathomimetic No MSN08 Up Fibrillar collagen core structure organization 1.07E-06 2 NaN COL11A1;COL11A2;COL1A2;COL2A1;COL3A1
isoprenaline Sympathomimetic No MSN09 Up Fibrillar collagen core structure organization 0.001638373 5 NaN COL11A1;COL2A1;COL3A1
isoprenaline Sympathomimetic No MSN01 Down Fibrillar collagen core structure organization 0.01368451 7 NaN COL2A1;COL5A1
isoprenaline Sympathomimetic No MSN08 Down Fibrillar collagen core structure organization 0.001270083 3.5 NaN COL1A1;COL5A1;COL5A2
isoprenaline Sympathomimetic No MSN08 Down G2 M transition checkpoint 0.02972276 16 NaN CCNB1;CDC25C
isoprenaline Sympathomimetic No MSN01 Down Gap junction organization 0.001908818 3 NaN GJA1;GJA3;GJC2
isoprenaline Sympathomimetic No MSN01 Up G-protein coupled receptor signaling pathway 0.01593556 15 NaN GRK5;PDE4D;RGS4
isoprenaline Sympathomimetic No MSN08 Up G-protein coupled receptor signaling pathway 0.008758754 12 NaN GRK5;PDE4D;RGS16
isoprenaline Sympathomimetic No MSN05 Up Granulocyte macrophage colony-stimulating factor receptor signaling 0.049824365 19 NaN JAK2
isoprenaline Sympathomimetic No MSN09 Up Granulocyte macrophage colony-stimulating factor receptor signaling 0.049480363 24 NaN JAK2
isoprenaline Sympathomimetic No MSN05 Down Granulocyte macrophage colony-stimulating factor receptor signaling 0.039477231 13 NaN JUND
isoprenaline Sympathomimetic No MSN08 Down Granulocyte macrophage colony-stimulating factor receptor signaling 0.045347487 22.5 NaN JUND
isoprenaline Sympathomimetic No MSN05 Up Inhibin receptor signaling 0.016062742 10 NaN INHBA;INHBB
isoprenaline Sympathomimetic No MSN09 Up Inhibition of amyloid aggregation, amyloid degradation and uptake 0.001845357 6 NaN A2M;PLAT
isoprenaline Sympathomimetic No MSN01 Up Inhibition of apoptosis 0.040336864 22 NaN BIRC5;PEA15
isoprenaline Sympathomimetic No MSN08 Down Inhibition of apoptosis 0.02972276 16 NaN BIRC3;BIRC5
isoprenaline Sympathomimetic No MSN01 Down JAK-STAT signaling pathway 0.026374299 13 NaN SOCS2;SOCS3
isoprenaline Sympathomimetic No MSN01 Up Lipogenesis 0.000731103 4 NaN ACLY;FASN
isoprenaline Sympathomimetic No MSN05 Up Lipogenesis 0.000634351 6 NaN ACLY;FASN
isoprenaline Sympathomimetic No MSN08 Up Lipogenesis 0.042932502 17 NaN FASN
isoprenaline Sympathomimetic No MSN09 Up Lipogenesis 0.000625494 4 NaN ACLY;FASN
isoprenaline Sympathomimetic No MSN05 Down Macrophage migration inhibitory factor signaling 0.003803269 3 NaN CXCR4;JUND
isoprenaline Sympathomimetic No MSN08 Down Macrophage migration inhibitory factor signaling 0.00500617 5.5 NaN CXCR4;JUND
isoprenaline Sympathomimetic No MSN08 Down Metaphase to anaphase checkpoint 0.042327049 19.5 NaN BUB1;CCNB2;PTTG1
isoprenaline Sympathomimetic No MSN05 Up Microfibril scaffold organization 0.049824365 19 NaN FBN1
isoprenaline Sympathomimetic No MSN09 Up Microfibril scaffold organization 0.049480363 24 NaN FBN1
isoprenaline Sympathomimetic No MSN01 Up Mitotic H3 phosphorylation and dephosphorylation 0.006925405 9 NaN CCNA2;RPS6KA3
isoprenaline Sympathomimetic No MSN08 Down WNT-Beta-catenin signaling pathway 0.015509275 9 NaN APCDD1;DACT1;FZD2;PAX6;SFRP5
isoprenaline Sympathomimetic No MSN01 Up Z-disc organization 0.000741893 5 NaN ACTN2;CSRP3;PDLIM3;TCAP
insulin-like growth factor 1 Hormone No MSN06 Down Z-disc organization 0.019421788 5 NaN LDB3;MYPN
insulin-like growth factor 1 Hormone No MSN01 Down Mitotic spindle assembly 0.041452288 20.5 NaN DLGAP5;TACC3
insulin-like growth factor 1 Hormone No MSN06 Up Mitotic spindle disassembly 0.031404375 21 NaN CDK1
insulin-like growth factor 1 Hormone No MSN01 Down Mitotic spindle disassembly 0.025317572 16.5 NaN CDK1
insulin-like growth factor 1 Hormone No MSN02 Down Muscarinic receptor signaling 0.024055739 24.5 NaN RGS4;RGS5
insulin-like growth factor 1 Hormone No MSN05 Down Muscarinic receptor signaling 0.024434507 25 NaN RGS4;RGS5
insulin-like growth factor 1 Hormone No MSN02 Up Myofibril formation 0.038158302 10.5 NaN KLHL41
insulin-like growth factor 1 Hormone No MSN05 Up Myofibril formation 0.033889149 7 NaN KLHL41
insulin-like growth factor 1 Hormone No MSN06 Up Natriuretic peptide receptor signaling 0.000572396 6 NaN NPPA;NPPB;NPR3
insulin-like growth factor 1 Hormone No MSN08 Up Natriuretic peptide receptor signaling 0.017688551 14.5 NaN NPPA;NPPB
insulin-like growth factor 1 Hormone No MSN01 Down Natriuretic peptide receptor signaling 0.008957388 7 NaN NPPA;NPPB
insulin-like growth factor 1 Hormone No MSN02 Down Natriuretic peptide receptor signaling 0.024055739 24.5 NaN NPPA;NPPB
insulin-like growth factor 1 Hormone No MSN05 Down Natriuretic peptide receptor signaling 0.00141304 7.5 NaN NPPA;NPPB;NPR3
insulin-like growth factor 1 Hormone No MSN02 Up Neuregulin receptor signaling 0.000792034 1 NaN ERBB3;ERBB4
insulin-like growth factor 1 Hormone No MSN05 Up Neuregulin receptor signaling 0.000622044 1 NaN ERBB4;SH3TC2
insulin-like growth factor 1 Hormone No MSN08 Up Non-vesicular phospholipid transport 0.024178298 18 NaN PITPNM1;PLTP
insulin-like growth factor 1 Hormone No MSN09 Up Non-vesicular phospholipid transport 0.021680107 16.5 NaN PITPNM1;PLTP
insulin-like growth factor 1 Hormone No MSN02 Down Non-vesicular phospholipid transport 0.03274279 27 NaN PITPNM1;PLTP
insulin-like growth factor 1 Hormone No MSN05 Down Non-vesicular phospholipid transport 0.033250529 26.5 NaN PITPNM1;PLTP
insulin-like growth factor 1 Hormone No MSN09 Up Notch receptor signaling 0.029047606 20 NaN DLK1;MIB2;NOTCH3
insulin-like growth factor 1 Hormone No MSN05 Down Notch receptor signaling 0.009286612 14 NaN DLK1;JAG1;LFNG;NOTCH3
insulin-like growth factor 1 Hormone No MSN01 Up Osteonectin receptor signaling 0.002114306 3 NaN SMOC2;SPARC
insulin-like growth factor 1 Hormone No MSN06 Up Osteonectin receptor signaling 0.00565842 10.5 NaN SMOC2;SPARC
insulin-like growth factor 1 Hormone No MSN08 Up Osteonectin receptor signaling 0.000181529 4 NaN SMOC2;SPARC;SPOCK1
insulin-like growth factor 1 Hormone No MSN09 Up Osteonectin receptor signaling 0.006629833 11.5 NaN SMOC2;SPARC
insulin-like growth factor 1 Hormone No MSN02 Down Osteonectin receptor signaling 0.010183037 17.5 NaN SMOC2;SPARC
insulin-like growth factor 1 Hormone No MSN05 Down Osteonectin receptor signaling 0.010348289 18 NaN SMOC2;SPARC
insulin-like growth factor 1 Hormone No MSN08 Up Osteopontin receptor signaling 0.036079746 28.5 NaN SPP1
insulin-like growth factor 1 Hormone No MSN09 Up Osteopontin receptor signaling 0.034050812 23 NaN SPP1
insulin-like growth factor 1 Hormone No MSN05 Down Osteopontin receptor signaling 0.042784051 30 NaN SPP1
insulin-like growth factor 1 Hormone No MSN09 Up Perlecan synthesis 0.034050812 23 NaN HSPG2
insulin-like growth factor 1 Hormone No MSN06 Up Platelet-derived growth factor receptor signaling 0.004199738 8 NaN PDGFRA;PDGFRB;RGS5
insulin-like growth factor 1 Hormone No MSN08 Up Platelet-derived growth factor receptor signaling 0.006196866 9 NaN PDGFRA;PDGFRB;RGS5
insulin-like growth factor 1 Hormone No MSN09 Up Platelet-derived growth factor receptor signaling 0.005271496 10 NaN PDGFRA;PDGFRB;RGS5
insulin-like growth factor 1 Hormone No MSN02 Down Platelet-derived growth factor receptor signaling 0.009707562 15.5 NaN PDGFRA;PDGFRB;RGS5
insulin-like growth factor 1 Hormone No MSN05 Down Platelet-derived growth factor receptor signaling 0.009930881 15.5 NaN PDGFRA;PDGFRB;RGS5
insulin-like growth factor 1 Hormone No MSN06 Down Potassium transmembrane transport 0.041630095 10 NaN ABCC9;ATP1A3
insulin-like growth factor 1 Hormone No MSN08 Down Potassium transmembrane transport 0.021280067 6.5 NaN ATP1A3;SLC12A6
insulin-like growth factor 1 Hormone No MSN02 Down Procollagen processing in the ER 0.005238589 10.5 NaN P3H1;SERPINH1
insulin-like growth factor 1 Hormone No MSN05 Down Procollagen processing in the ER 0.005324882 11.5 NaN P3H1;SERPINH1
insulin-like growth factor 1 Hormone No MSN08 Down Progestagen synthesis 0.037229472 12.5 NaN HSD17B2
insulin-like growth factor 1 Hormone No MSN09 Down Progestagen synthesis 0.037229472 9 NaN HSD17B2
insulin-like growth factor 1 Hormone No MSN02 Down Proline metabolism 0.000712142 6 NaN ALDH18A1;OAT;PYCR1
insulin-like growth factor 1 Hormone No MSN08 Down Prostaglandin PGF2 alpha receptor signaling 0.018789642 4.5 NaN PTGFR
insulin-like growth factor 1 Hormone No MSN09 Down Prostaglandin PGF2 alpha receptor signaling 0.018789642 6.5 NaN PTGFR
insulin-like growth factor 1 Hormone No MSN06 Up Pyrimidine synthesis and salvage 0.024293237 18.5 NaN TK1;TYMS
insulin-like growth factor 1 Hormone No MSN08 Up Pyrimidine synthesis and salvage 0.031477664 23 NaN TK1;TYMS
insulin-like growth factor 1 Hormone No MSN01 Up Removal of caspase inhibition 0.037747261 10.5 NaN XAF1
insulin-like growth factor 1 Hormone No MSN06 Up Restriction point 0.037460883 23.5 NaN CDKN2A;E2F1
insulin-like growth factor 1 Hormone No MSN09 Up Restriction point 0.04343155 26.5 NaN CDKN1A;CDKN2A
insulin-like growth factor 1 Hormone No MSN06 Up Retinol metabolism 3.10E-05 4 NaN ALDH1A1;ALDH1A2;ALDH1A3;DHRS3;RDH10
insulin-like growth factor 1 Hormone No MSN08 Up Retinol metabolism 0.000921206 5 NaN ALDH1A1;ALDH1A2;RBP1;RPE65
insulin-like growth factor 1 Hormone No MSN09 Up Retinol metabolism 0.000741131 5 NaN ALDH1A2;DHRS3;RDH10;RPE65
insulin-like growth factor 1 Hormone No MSN01 Down Retinol metabolism 0.041452288 20.5 NaN ALDH1A3;TTR
insulin-like growth factor 1 Hormone No MSN02 Down Retinol metabolism 0.015797741 20 NaN ALDH1A1;ALDH1A3;TTR
insulin-like growth factor 1 Hormone No MSN05 Down Retinol metabolism 0.016152676 21 NaN ALDH1A1;ALDH1A3;TTR
insulin-like growth factor 1 Hormone No MSN08 Down RIG-I-like receptor signaling 0.037229472 12.5 NaN MAVS
insulin-like growth factor 1 Hormone No MSN01 Down Serine and glycine metabolism 0.000115374 1 NaN PHGDH;PSAT1;SHMT2;SLC1A5
insulin-like growth factor 1 Hormone No MSN05 Down Serine and glycine metabolism 0.009930881 15.5 NaN PSAT1;SHMT2;SLC1A5
insulin-like growth factor 1 Hormone No MSN06 Down Serine and glycine metabolism 0.000374503 1 NaN PHGDH;PSAT1;SHMT2
insulin-like growth factor 1 Hormone No MSN08 Down Serine and glycine metabolism 0.000127684 1 NaN PHGDH;PSAT1;SHMT2
insulin-like growth factor 1 Hormone No MSN09 Down Serine and glycine metabolism 0.000127684 1 NaN PHGDH;PSAT1;SHMT2
insulin-like growth factor 1 Hormone No MSN06 Down Serotonin and melatonin synthesis 0.040207462 8.5 NaN SLC6A4
insulin-like growth factor 1 Hormone No MSN01 Up Serotonin inactivation 0.037747261 10.5 NaN MAOA
insulin-like growth factor 1 Hormone No MSN01 Down Sister chromatid attachment to mitotic spindle 0.049996342 24 NaN TACC3
insulin-like growth factor 1 Hormone No MSN06 Up Sister chromatid cohesion 0.046821378 27 NaN CDCA5;CHTF18;RFC3
insulin-like growth factor 1 Hormone No MSN08 Down Syndecan ectodomain shedding 0.037229472 12.5 NaN ADAMTS1
insulin-like growth factor 1 Hormone No MSN02 Up Thick myofilament organization 0.0116002 4 NaN MYH7
insulin-like growth factor 1 Hormone No MSN06 Down Thick myofilament organization 0.000545195 2 NaN MYH7;TTN
insulin-like growth factor 1 Hormone No MSN02 Up Thin myofilament organization 0.026862767 8.5 NaN TNNI3
insulin-like growth factor 1 Hormone No MSN08 Up Thin myofilament organization 0.024178298 18 NaN ACTA1;TPM2
insulin-like growth factor 1 Hormone No MSN01 Down Thin myofilament organization 0.012331868 8.5 NaN ACTA1;TPM4
insulin-like growth factor 1 Hormone No MSN02 Down Thin myofilament organization 0.03274279 27 NaN TPM2;TPM4
insulin-like growth factor 1 Hormone No MSN05 Down Thin myofilament organization 0.00239445 10 NaN ACTA1;TPM2;TPM4
insulin-like growth factor 1 Hormone No MSN08 Up Thrombospondin receptor signaling 0.00742401 10.5 NaN THBS1;THBS2
insulin-like growth factor 1 Hormone No MSN05 Down Thrombospondin receptor signaling 0.010348289 18 NaN THBS2;THBS4
insulin-like growth factor 1 Hormone No MSN08 Up Tight junction organization 0.032967469 25 NaN CLDN11;CLDN6;CRB2;EMP1
insulin-like growth factor 1 Hormone No MSN09 Up Tight junction organization 0.027422091 18 NaN CLDN11;CLDN4;CLDN6;CRB2
insulin-like growth factor 1 Hormone No MSN06 Up Tropoelastin synthesis 0.031404375 21 NaN ELN
insulin-like growth factor 1 Hormone No MSN08 Up Tropoelastin synthesis 0.036079746 28.5 NaN ELN
insulin-like growth factor 1 Hormone No MSN09 Up Tropoelastin synthesis 0.034050812 23 NaN ELN
insulin-like growth factor 1 Hormone No MSN01 Down Tropoelastin synthesis 0.025317572 16.5 NaN ELN
insulin-like growth factor 1 Hormone No MSN05 Down Tropoelastin synthesis 0.042784051 30 NaN ELN
insulin-like growth factor 1 Hormone No MSN08 Down Tyrosine metabolism 0.046320227 17 NaN TYR
insulin-like growth factor 1 Hormone No MSN09 Down Tyrosine metabolism 0.046320227 10 NaN TYR
insulin-like growth factor 1 Hormone No MSN08 Up Versican synthesis 0.036079746 28.5 NaN VCAN
insulin-like growth factor 1 Hormone No MSN09 Up Versican synthesis 0.034050812 23 NaN VCAN
insulin-like growth factor 1 Hormone No MSN08 Up WNT-Beta-catenin signaling pathway 0.02741903 21 NaN APCDD1;CTHRC1;DACT1;FRZB;PAX6;SFRP2
insulin-like growth factor 1 Hormone No MSN09 Up WNT-Beta-catenin signaling pathway 0.021357683 15 NaN APCDD1;CTHRC1;FRZB;SFRP2;SFRP4;WNT2
insulin-like growth factor 1 Hormone No MSN02 Down WNT-Beta-catenin signaling pathway 0.005436307 13 NaN CTHRC1;DKK2;DKK3;FRZB;FZD7;SFRP2;SFRP4;WNT2
insulin-like growth factor 1 Hormone No MSN05 Down WNT-Beta-catenin signaling pathway 0.019022812 24 NaN CTHRC1;DKK2;FRZB;FZD7;SFRP2;SFRP4;WNT2
insulin-like growth factor 1 Hormone No MSN02 Down Actin filament bundling and crosslinking 0.022802563 23 NaN FLNA;PLS3;SYNPO;TAGLN
insulin-like growth factor 1 Hormone No MSN06 Down Actin filament bundling and crosslinking 0.048169549 11 NaN SYNPO2;USH1C
insulin-like growth factor 1 Hormone No MSN06 Down Acute-phase response 0.040207462 8.5 NaN TTR
insulin-like growth factor 1 Hormone No MSN01 Down Aggrecan synthesis 0.025317572 16.5 NaN ACAN
insulin-like growth factor 1 Hormone No MSN05 Down Aggrecan synthesis 0.042784051 30 NaN ACAN
insulin-like growth factor 1 Hormone No MSN08 Down Aggrecan synthesis 0.009438956 3 NaN ACAN
insulin-like growth factor 1 Hormone No MSN01 Up Albumin mediated blood protein transport 0.01905434 6.5 NaN ALB
insulin-like growth factor 1 Hormone No MSN06 Down Albumin mediated blood protein transport 0.013585039 4 NaN ALB
insulin-like growth factor 1 Hormone No MSN09 Up Alternative complement pathway 0.010801555 13 NaN C1S;C3
insulin-like growth factor 1 Hormone No MSN02 Down Alternative complement pathway 0.016496966 21.5 NaN C1S;CFH
insulin-like growth factor 1 Hormone No MSN05 Down Alternative complement pathway 0.016760685 22.5 NaN C1S;CFH
insulin-like growth factor 1 Hormone No MSN02 Down Amyloid plaque organization 0.009707562 15.5 NaN APBB2;APOE;VSNL1
insulin-like growth factor 1 Hormone No MSN06 Down Androgen receptor signaling 0.026986707 6 NaN AR
insulin-like growth factor 1 Hormone No MSN01 Down Antigen presentation via MHC class I molecules 0.025134697 13.5 NaN HLA-A;HLA-C
insulin-like growth factor 1 Hormone No MSN02 Down Antigen presentation via MHC class I molecules 0.007287079 14 NaN B2M;HLA-B;HLA-C
insulin-like growth factor 1 Hormone No MSN05 Down Antigen presentation via MHC class I molecules 0.007456689 13 NaN B2M;HLA-B;HLA-C
insulin-like growth factor 1 Hormone No MSN01 Down Aspartate and arginine metabolism 0.025134697 13.5 NaN ARG2;SLC7A1
insulin-like growth factor 1 Hormone No MSN06 Down Aspartate and arginine metabolism 0.007681705 3 NaN ARG2;SLC7A1
insulin-like growth factor 1 Hormone No MSN09 Down Aspartate and arginine metabolism 0.003780508 3 NaN ARG2;SLC7A1
insulin-like growth factor 1 Hormone No MSN08 Up Axonal intermediate filament dynamics 0.024178298 18 NaN NEFH;NES
insulin-like growth factor 1 Hormone No MSN01 Down Axonal intermediate filament dynamics 0.012331868 8.5 NaN NEFL;NES
insulin-like growth factor 1 Hormone No MSN02 Up Basement membrane assembly and organization 0.038158302 10.5 NaN LAMA2
insulin-like growth factor 1 Hormone No MSN09 Up Basement membrane assembly and organization 0.04343155 26.5 NaN COL8A2;HSPG2
insulin-like growth factor 1 Hormone No MSN05 Up Betaglycan signaling 0.017086874 4 NaN TGFBR3
insulin-like growth factor 1 Hormone No MSN08 Down Betaglycan signaling 0.046320227 17 NaN TGFBR3
insulin-like growth factor 1 Hormone No MSN09 Down Bicarbonate transmembrane transport 0.013593392 5 NaN CA9;SLC4A5
insulin-like growth factor 1 Hormone No MSN08 Up Biglycan synthesis 0.036079746 28.5 NaN BGN
insulin-like growth factor 1 Hormone No MSN01 Down Biglycan synthesis 0.025317572 16.5 NaN BGN
insulin-like growth factor 1 Hormone No MSN05 Down Biglycan synthesis 0.042784051 30 NaN BGN
insulin-like growth factor 1 Hormone No MSN02 Up Cardiomyocyte depolarization during action potential 0.00388144 2 NaN SCN5A
insulin-like growth factor 1 Hormone No MSN05 Up Cardiomyocyte repolarization during action potential and hyperpolarization 0.001022508 2 NaN KCNIP2;KCNQ5
insulin-like growth factor 1 Hormone No MSN01 Down CCN intercellular signaling protein family receptor signaling 0.000154653 2 NaN CTGF;CYR61;NOV
insulin-like growth factor 1 Hormone No MSN02 Down CCN intercellular signaling protein family receptor signaling 0.000712142 6 NaN CTGF;CYR61;WISP1
insulin-like growth factor 1 Hormone No MSN05 Down CCN intercellular signaling protein family receptor signaling 1.60E-05 2 NaN CTGF;CYR61;NOV;WISP1
insulin-like growth factor 1 Hormone No MSN08 Down CCN intercellular signaling protein family receptor signaling 0.046320227 17 NaN CYR61
insulin-like growth factor 1 Hormone No MSN01 Up CD44-Mediated leukocyte rolling 0.037747261 10.5 NaN CD44
insulin-like growth factor 1 Hormone No MSN06 Up Centrosome separation 0.037460883 23.5 NaN CCNB1;CDK1
insulin-like growth factor 1 Hormone No MSN01 Down Centrosome separation 0.001688656 5 NaN CCNB1;CDK1;KIF11
insulin-like growth factor 1 Hormone No MSN08 Up Cholesterol synthesis 3.90E-06 3 NaN DHCR24;DHCR7;FDPS;HMGCR;HMGCS1;MSMO1;MVD
insulin-like growth factor 1 Hormone No MSN02 Up Cholesterol-sensitive control of SREBP activation 0.023068859 7 NaN INSIG1
insulin-like growth factor 1 Hormone No MSN05 Up Cholesterol-sensitive control of SREBP activation 0.020469948 5 NaN INSIG1
insulin-like growth factor 1 Hormone No MSN06 Up Cholesterol-sensitive control of SREBP activation 0.01356683 16.5 NaN INSIG1;SREBF1
insulin-like growth factor 1 Hormone No MSN08 Up Cholesterol-sensitive control of SREBP activation 0.017688551 14.5 NaN INSIG1;SREBF1
insulin-like growth factor 1 Hormone No MSN09 Up Cholesterol-sensitive control of SREBP activation 0.015839486 14 NaN INSIG1;SREBF1
insulin-like growth factor 1 Hormone No MSN09 Up Classical complement pathway 0.021680107 16.5 NaN C1R;C1S
insulin-like growth factor 1 Hormone No MSN02 Down Classical complement pathway 0.000101168 3 NaN C1QB;C1QC;C1R;C1S
insulin-like growth factor 1 Hormone No MSN05 Down Classical complement pathway 0.000104494 4 NaN C1QB;C1QC;C1R;C1S
insulin-like growth factor 1 Hormone No MSN01 Up Coagulation cascade 0.021034131 8 NaN F5;TFPI
insulin-like growth factor 1 Hormone No MSN06 Up Collagen fiber crosslinking 0.009235352 14.5 NaN LOX;LOXL1
insulin-like growth factor 1 Hormone No MSN08 Up Collagen fiber crosslinking 0.012078917 13 NaN LOX;LOXL1
insulin-like growth factor 1 Hormone No MSN09 Up Collagen fiber crosslinking 0.000372249 3 NaN LOX;LOXL1;PXDN
insulin-like growth factor 1 Hormone No MSN02 Down Collagen fiber crosslinking 0.000712142 6 NaN LOX;LOXL1;PXDN
insulin-like growth factor 1 Hormone No MSN05 Down Collagen fiber crosslinking 0.000729697 6 NaN LOX;LOXL1;PXDN
insulin-like growth factor 1 Hormone No MSN01 Up Collagen fibril organization by fibril-associated bridges 0.005154036 4 NaN COL14A1;COL9A3
insulin-like growth factor 1 Hormone No MSN06 Up Collagen fibril organization by fibril-associated bridges 0.01356683 16.5 NaN COL9A2;COL9A3
insulin-like growth factor 1 Hormone No MSN08 Up Collagen fibril organization by fibril-associated bridges 3.48E-07 2 NaN COL12A1;COL14A1;COL9A1;COL9A2;COL9A3
insulin-like growth factor 1 Hormone No MSN09 Up Collagen fibril organization by fibril-associated bridges 0.000725692 4 NaN COL14A1;COL9A2;COL9A3
insulin-like growth factor 1 Hormone No MSN02 Down Collagen fibril organization by fibril-associated bridges 0.001379421 8 NaN COL14A1;COL9A1;COL9A3
insulin-like growth factor 1 Hormone No MSN05 Down Collagen fibril organization by fibril-associated bridges 0.00141304 7.5 NaN COL14A1;COL9A1;COL9A2
insulin-like growth factor 1 Hormone No MSN02 Up Contractile ring constriction 0.019260498 5.5 NaN MYH14
insulin-like growth factor 1 Hormone No MSN08 Down Contractile ring constriction 0.046320227 17 NaN MYLK
insulin-like growth factor 1 Hormone No MSN02 Up Contractile ring formation 0.019260498 5.5 NaN MYH14
insulin-like growth factor 1 Hormone No MSN01 Up Decorin synthesis 0.01905434 6.5 NaN DCN
insulin-like growth factor 1 Hormone No MSN06 Up Decorin synthesis 0.031404375 21 NaN DCN
insulin-like growth factor 1 Hormone No MSN08 Up Decorin synthesis 0.036079746 28.5 NaN DCN
insulin-like growth factor 1 Hormone No MSN09 Up Decorin synthesis 0.034050812 23 NaN DCN
insulin-like growth factor 1 Hormone No MSN05 Down Decorin synthesis 0.042784051 30 NaN DCN
insulin-like growth factor 1 Hormone No MSN02 Up Desaturation of fatty acids 0.026862767 8.5 NaN SCD
insulin-like growth factor 1 Hormone No MSN08 Up Desaturation of fatty acids 0.024178298 18 NaN FADS2;SCD
insulin-like growth factor 1 Hormone No MSN09 Up Discoidin domain receptor signaling 0.003391299 8 NaN DDR1;DDR2
insulin-like growth factor 1 Hormone No MSN06 Up DNA cleavage 0.044852248 26 NaN ENDOG;FEN1
insulin-like growth factor 1 Hormone No MSN06 Up DNA replication elongation 0.009235352 14.5 NaN MCM2;PCNA
insulin-like growth factor 1 Hormone No MSN06 Up DNA replication initiation 9.82E-05 5 NaN CDC45;CDC6;GINS1;GINS2;MCM10;MCM2
insulin-like growth factor 1 Hormone No MSN06 Up Elastin cross-linking and assembly 0.002889214 7 NaN LOX;LOXL1
insulin-like growth factor 1 Hormone No MSN08 Up Elastin cross-linking and assembly 0.003802769 7.5 NaN LOX;LOXL1
insulin-like growth factor 1 Hormone No MSN09 Up Elastin cross-linking and assembly 0.003391299 8 NaN LOX;LOXL1
insulin-like growth factor 1 Hormone No MSN02 Down Elastin cross-linking and assembly 0.005238589 10.5 NaN LOX;LOXL1
insulin-like growth factor 1 Hormone No MSN05 Down Elastin cross-linking and assembly 0.005324882 11.5 NaN LOX;LOXL1
insulin-like growth factor 1 Hormone No MSN02 Down Endogenous control of complement activity 0.016496966 21.5 NaN CFH;CFI
insulin-like growth factor 1 Hormone No MSN05 Down Endogenous control of complement activity 0.016760685 22.5 NaN CFH;CFI
insulin-like growth factor 1 Hormone No MSN06 Up Epithelial intermediate filament dynamics 0.024293237 18.5 NaN KRT19;KRT7
insulin-like growth factor 1 Hormone No MSN08 Up Epithelial intermediate filament dynamics 0.031477664 23 NaN KRT19;KRT7
insulin-like growth factor 1 Hormone No MSN01 Down Epithelial intermediate filament dynamics 0.000818308 4 NaN KRT7;KRT8;TCHH
insulin-like growth factor 1 Hormone No MSN06 Up Eukaryotic kinetochore dynamics 1.96E-06 2 NaN BUB1;CENPU;MAD2L1;NDC80;NUF2;SKA3;SPC24;ZWILCH;ZWINT
insulin-like growth factor 1 Hormone No MSN01 Up Extracellular matrix breakdown and membrane shedding by adamalysins 0.010279166 5 NaN ADAM15;ADAM33;ADAMTS14
insulin-like growth factor 1 Hormone No MSN05 Up Extracellular matrix breakdown and membrane shedding by adamalysins 0.003034624 3 NaN ADAMTS14;ADAMTS5
insulin-like growth factor 1 Hormone No MSN06 Up Extracellular matrix breakdown and membrane shedding by adamalysins 0.038149737 25 NaN ADAM12;ADAM33;ADAMTS14
insulin-like growth factor 1 Hormone No MSN08 Up Extracellular matrix breakdown and membrane shedding by adamalysins 0.010005113 12 NaN ADAM12;ADAM33;ADAMTS12;ADAMTS2
insulin-like growth factor 1 Hormone No MSN09 Up Extracellular matrix breakdown and membrane shedding by adamalysins 0.001109954 6 NaN ADAM12;ADAM33;ADAMTS14;ADAMTS2;ADAMTS6
insulin-like growth factor 1 Hormone No MSN02 Down Extracellular matrix breakdown and membrane shedding by adamalysins 0.000396138 4 NaN ADAM12;ADAM33;ADAMTS10;ADAMTS12;ADAMTS2;ADAMTS4
insulin-like growth factor 1 Hormone No MSN05 Down Extracellular matrix breakdown and membrane shedding by adamalysins 0.000414113 5 NaN ADAM12;ADAM33;ADAMTS12;ADAMTS2;ADAMTS4;ADAMTS8
insulin-like growth factor 1 Hormone No MSN08 Down Extracellular matrix breakdown and membrane shedding by adamalysins 0.021280067 6.5 NaN ADAMTS1;ADAMTS5
insulin-like growth factor 1 Hormone No MSN06 Up Extracellular matrix breakdown by heparanases and sulfatases 0.00565842 10.5 NaN SULF1;SULF2
insulin-like growth factor 1 Hormone No MSN08 Up Extracellular matrix breakdown by heparanases and sulfatases 0.00742401 10.5 NaN SULF1;SULF2
insulin-like growth factor 1 Hormone No MSN09 Up Extracellular matrix breakdown by heparanases and sulfatases 0.006629833 11.5 NaN SULF1;SULF2
insulin-like growth factor 1 Hormone No MSN02 Down Extracellular matrix breakdown by heparanases and sulfatases 0.010183037 17.5 NaN SULF1;SULF2
insulin-like growth factor 1 Hormone No MSN05 Down Extracellular matrix breakdown by heparanases and sulfatases 0.010348289 18 NaN SULF1;SULF2
insulin-like growth factor 1 Hormone No MSN01 Up Extracellular matrix breakdown by matrix metalloproteases 0.000526515 2 NaN MMP14;MMP2;MMP3
insulin-like growth factor 1 Hormone No MSN06 Up Extracellular matrix breakdown by matrix metalloproteases 3.37E-06 3 NaN MMP1;MMP12;MMP14;MMP2;MMP3
insulin-like growth factor 1 Hormone No MSN09 Up Extracellular matrix breakdown by matrix metalloproteases 0.000145581 2 NaN MMP12;MMP14;MMP2;MMP3
insulin-like growth factor 1 Hormone No MSN02 Down Extracellular matrix breakdown by matrix metalloproteases 0.005265369 12 NaN MMP1;MMP14;MMP2
insulin-like growth factor 1 Hormone No MSN08 Up Extracellular matrix breakdown by serine proteases 0.024178298 18 NaN HTRA1;PRSS12
insulin-like growth factor 1 Hormone No MSN02 Down Extracellular matrix breakdown by serine proteases 0.03274279 27 NaN HTRA1;PRSS12
insulin-like growth factor 1 Hormone No MSN05 Down Extracellular matrix breakdown by serine proteases 0.033250529 26.5 NaN HTRA1;PRSS12
insulin-like growth factor 1 Hormone No MSN06 Up Fanconi anemia interstrand cross-link repair pathway 0.008273573 13 NaN BRCA2;BRIP1;FANCI;UBE2T
insulin-like growth factor 1 Hormone No MSN01 Up Fibrillar collagen core structure organization 8.80E-09 1 NaN COL11A2;COL1A1;COL1A2;COL3A1;COL5A1;COL5A2
insulin-like growth factor 1 Hormone No MSN06 Up Fibrillar collagen core structure organization 3.73E-11 1 NaN COL11A1;COL11A2;COL1A1;COL1A2;COL2A1;COL3A1;COL5A1;COL5A2
insulin-like growth factor 1 Hormone No MSN08 Up Fibrillar collagen core structure organization 8.27E-09 1 NaN COL11A1;COL1A1;COL1A2;COL2A1;COL3A1;COL5A1;COL5A2
insulin-like growth factor 1 Hormone No MSN09 Up Fibrillar collagen core structure organization 2.81E-07 1 NaN COL11A1;COL1A1;COL1A2;COL3A1;COL5A1;COL5A2
insulin-like growth factor 1 Hormone No MSN02 Down Fibrillar collagen core structure organization 2.55E-08 1 NaN COL11A1;COL1A1;COL1A2;COL3A1;COL5A1;COL5A2;COL5A3
insulin-like growth factor 1 Hormone No MSN05 Down Fibrillar collagen core structure organization 2.70E-08 1 NaN COL11A1;COL1A1;COL1A2;COL3A1;COL5A1;COL5A2;COL5A3
insulin-like growth factor 1 Hormone No MSN09 Down Fibroblast growth factor receptor signaling 0.005476881 4 NaN FGF1;FGF18
insulin-like growth factor 1 Hormone No MSN06 Up G2 M transition checkpoint 0.005470465 9 NaN CCNB1;CDC25C;CDK1
insulin-like growth factor 1 Hormone No MSN01 Down G2 M transition checkpoint 0.035660258 19 NaN CCNB1;CDK1
insulin-like growth factor 1 Hormone No MSN05 Up Gap junction organization 0.047129162 8 NaN GJA5
insulin-like growth factor 1 Hormone No MSN01 Down Glutamate and glutamine metabolism 0.00380409 6 NaN SLC1A5;SLC38A2;SLC7A5
insulin-like growth factor 1 Hormone No MSN08 Up Glycolysis and Gluconeogenesis 0.00117197 6 NaN ENO1;LDHA;PGAM1;PGK1;TPI1
insulin-like growth factor 1 Hormone No MSN01 Down Glycolysis and Gluconeogenesis 0.019552723 12 NaN ENO1;LDHA;PCK2
insulin-like growth factor 1 Hormone No MSN06 Down Glycolysis and Gluconeogenesis 0.038497269 7 NaN HK2;PCK2
insulin-like growth factor 1 Hormone No MSN09 Down Glycolysis and Gluconeogenesis 0.001262037 2 NaN HK2;PFKFB3;PFKFB4
insulin-like growth factor 1 Hormone No MSN01 Down Granulocyte macrophage colony-stimulating factor receptor signaling 0.049996342 24 NaN JAK2
insulin-like growth factor 1 Hormone No MSN08 Up Growth differentiation factor receptor signaling 0.031477664 23 NaN GDF15;GDF6
insulin-like growth factor 1 Hormone No MSN09 Up Growth differentiation factor receptor signaling 0.028263201 19 NaN GDF15;GDF6
insulin-like growth factor 1 Hormone No MSN01 Down Growth differentiation factor receptor signaling 0.016169721 10.5 NaN GDF2;GDF6
insulin-like growth factor 1 Hormone No MSN08 Down Heparin-binding EGF-like growth factor receptor signaling 0.028052877 8.5 NaN HBEGF
insulin-like growth factor 1 Hormone No MSN01 Down Hepatocyte growth factor receptor signaling 0.000638802 3 NaN HGF;MET
insulin-like growth factor 1 Hormone No MSN08 Down Hepatocyte growth factor receptor signaling 0.018789642 4.5 NaN MET
insulin-like growth factor 1 Hormone No MSN09 Down Hepatocyte growth factor receptor signaling 0.018789642 6.5 NaN MET
insulin-like growth factor 1 Hormone No MSN05 Up Inhibin receptor signaling 0.027202094 6 NaN TGFBR3
insulin-like growth factor 1 Hormone No MSN01 Down Inhibin receptor signaling 0.016169721 10.5 NaN INHBA;INHBE
insulin-like growth factor 1 Hormone No MSN08 Down Inhibin receptor signaling 0.002381506 2 NaN INHBE;TGFBR3
insulin-like growth factor 1 Hormone No MSN08 Up Inhibition of amyloid aggregation, amyloid degradation and uptake 0.003802769 7.5 NaN MME;PLAT
insulin-like growth factor 1 Hormone No MSN09 Up Inhibition of amyloid aggregation, amyloid degradation and uptake 0.003391299 8 NaN MME;PLAT
insulin-like growth factor 1 Hormone No MSN02 Down Inhibition of amyloid aggregation, amyloid degradation and uptake 7.59E-05 2 NaN A2M;MME;PLAT
insulin-like growth factor 1 Hormone No MSN05 Down Inhibition of amyloid aggregation, amyloid degradation and uptake 7.79E-05 3 NaN A2M;MME;PLAT
insulin-like growth factor 1 Hormone No MSN08 Down Inhibition of amyloid aggregation, amyloid degradation and uptake 0.028052877 8.5 NaN A2M
insulin-like growth factor 1 Hormone No MSN09 Down Inhibition of amyloid aggregation, amyloid degradation and uptake 0.028052877 8 NaN A2M
insulin-like growth factor 1 Hormone No MSN02 Down Inhibition of apoptosis 0.012541065 19 NaN IFI6;PEA15;XAF1
insulin-like growth factor 1 Hormone No MSN05 Down Inhibition of apoptosis 0.01282619 20 NaN IFI6;PEA15;XAF1
insulin-like growth factor 1 Hormone No MSN01 Down JAK-STAT signaling pathway 0.047569054 22 NaN SOCS2;STAT4
insulin-like growth factor 1 Hormone No MSN08 Up Ketone body metabolism 0.036079746 28.5 NaN OXCT1
insulin-like growth factor 1 Hormone No MSN08 Down Leptin receptor signaling 0.037229472 12.5 NaN SOCS3
insulin-like growth factor 1 Hormone No MSN02 Up Lipogenesis 0.007748155 3 NaN FASN
insulin-like growth factor 1 Hormone No MSN08 Down Macrophage migration inhibitory factor signaling 0.046320227 17 NaN ACKR3
insulin-like growth factor 1 Hormone No MSN08 Down MAPK signaling pathway 0.03233682 10 NaN MAP2K6;RPS6KA2
insulin-like growth factor 1 Hormone No MSN01 Down Methionine cycle 0.049996342 24 NaN BHMT
insulin-like growth factor 1 Hormone No MSN01 Up Microfibril scaffold organization 0.037747261 10.5 NaN FBN1
insulin-like growth factor 1 Hormone No MSN02 Down Microfibril scaffold organization 0.001796822 9 NaN FBN1;MFAP2
insulin-like growth factor 1 Hormone No MSN05 Down Microfibril scaffold organization 0.001826862 9 NaN FBN1;MFAP2
insulin-like growth factor 1 Hormone No MSN06 Up Mitotic spindle assembly 0.006947804 12 NaN DLGAP5;NUSAP1;TPX2
imatinib Kinase inhibitor No MSN01 Up Eukaryotic kinetochore dynamics 0.00579113 10 NaN BUB1;CENPF;NDC80;NUF2
imatinib Kinase inhibitor No MSN05 Up Eukaryotic kinetochore dynamics 0.001386982 6 NaN BUB1;CENPE;CENPF;NDC80
imatinib Kinase inhibitor No MSN06 Up Eukaryotic kinetochore dynamics 8.59E-05 4 NaN BUB1;CENPE;CENPF;KNSTRN;MAD2L1;NDC80;SPC24
imatinib Kinase inhibitor No MSN09 Up Extracellular matrix breakdown and membrane shedding by adamalysins 0.009275913 5 NaN ADAM12;ADAM33;ADAMTS5
imatinib Kinase inhibitor No MSN05 Down Extracellular matrix breakdown and membrane shedding by adamalysins 0.001046931 4 NaN ADAM12;ADAM33;ADAMTS2;ADAMTS4;ADAMTS8
imatinib Kinase inhibitor No MSN09 Down Extracellular matrix breakdown and membrane shedding by adamalysins 0.019611477 8 NaN ADAMTS14;ADAMTS2;ADAMTS8
imatinib Kinase inhibitor No MSN06 Down Extracellular matrix breakdown by cathepsins 0.010046743 5 NaN CTSF;CTSV
imatinib Kinase inhibitor No MSN06 Up Extracellular matrix breakdown by heparanases and sulfatases 0.004703576 16 NaN SULF1;SULF2
imatinib Kinase inhibitor No MSN05 Down Extracellular matrix breakdown by heparanases and sulfatases 0.006462844 9.5 NaN SULF1;SULF2
imatinib Kinase inhibitor No MSN05 Down Extracellular matrix breakdown by matrix metalloproteases 0.002720354 7 NaN MMP1;MMP14;MMP2
imatinib Kinase inhibitor No MSN09 Up Fibrillar collagen core structure organization 0.01368451 6 NaN COL1A1;COL5A2
imatinib Kinase inhibitor No MSN05 Down Fibrillar collagen core structure organization 5.05E-09 1 NaN COL11A1;COL1A1;COL1A2;COL3A1;COL5A1;COL5A2;COL5A3
imatinib Kinase inhibitor No MSN09 Down Fibroblast growth factor receptor signaling 0.032966818 12.5 NaN FGF10;FGFR3
imatinib Kinase inhibitor No MSN01 Up G2 M transition checkpoint 0.001339555 8 NaN CCNB1;CDC25B;CDK1
imatinib Kinase inhibitor No MSN05 Up G2 M transition checkpoint 0.00999102 12 NaN CCNB1;CDK1
imatinib Kinase inhibitor No MSN06 Up G2 M transition checkpoint 0.000270376 7.5 NaN CCNB1;CDC25B;CDC25C;CDK1
imatinib Kinase inhibitor No MSN09 Up GABA metabolism 0.004787543 2.5 NaN ABAT;SLC6A1
imatinib Kinase inhibitor No MSN09 Up Gap junction organization 0.026374299 13.5 NaN GJA1;GJA5
imatinib Kinase inhibitor No MSN01 Down Gap junction organization 0.042309999 12 NaN GJC2;PANX1
imatinib Kinase inhibitor No MSN01 Down Glutamate and glutamine metabolism 0.036831666 11 NaN GLS;SLC38A2
imatinib Kinase inhibitor No MSN06 Down Glutamate and glutamine metabolism 0.016888017 7 NaN SLC1A5;SLC7A5
imatinib Kinase inhibitor No MSN05 Up Glycogen synthesis and glycogenolysis 0.017564804 16 NaN PPP1R3C;PYGM
imatinib Kinase inhibitor No MSN09 Down Glycolysis and Gluconeogenesis 5.20E-11 1 NaN ALDOA;ENO1;HK2;LDHA;PFKFB3;PFKFB4;PFKL;PGAM1;PGK1;TPI1
imatinib Kinase inhibitor No MSN06 Down G-protein coupled receptor signaling pathway 0.03831226 11.5 NaN PDE4D;RGS6
imatinib Kinase inhibitor No MSN01 Down Granulocyte macrophage colony-stimulating factor receptor signaling 0.046898366 15.5 NaN JAK2
imatinib Kinase inhibitor No MSN05 Down Growth differentiation factor receptor signaling 0.027583816 14.5 NaN GDF15;GDF6
imatinib Kinase inhibitor No MSN05 Down Hepatocyte growth factor receptor signaling 0.001126749 5 NaN HGF;MET
imatinib Kinase inhibitor No MSN09 Down Hepatocyte growth factor receptor signaling 0.047931585 16 NaN HGF
imatinib Kinase inhibitor No MSN09 Down HIF-1 receptor signaling pathway 0.018861962 7 NaN EGLN1;EGLN3
imatinib Kinase inhibitor No MSN06 Down Hyaluronan synthesis 0.046118342 13.5 NaN HAS2
imatinib Kinase inhibitor No MSN05 Down Inhibition of amyloid aggregation, amyloid degradation and uptake 0.003304892 8 NaN MME;PLAT
imatinib Kinase inhibitor No MSN05 Up Inhibition of apoptosis 0.00999102 12 NaN BIRC5;IFI6
imatinib Kinase inhibitor No MSN01 Down Inhibition of apoptosis 0.031652619 10 NaN IFI6;XAF1
imatinib Kinase inhibitor No MSN05 Up Intracellular bridge assembly 0.038145795 20 NaN KIF23
imatinib Kinase inhibitor No MSN06 Up Intracellular bridge assembly 0.002397082 13.5 NaN INCENP;KIF23
imatinib Kinase inhibitor No MSN09 Up JAK-STAT signaling pathway 0.026374299 13.5 NaN SOCS2;STAT4
imatinib Kinase inhibitor No MSN09 Down Lamellipodium organization 0.035387843 14 NaN ARAP3;ENAH;TIAM2
imatinib Kinase inhibitor No MSN06 Down Lipid droplet mitochondria interaction 0.046118342 13.5 NaN SNAP23
imatinib Kinase inhibitor No MSN01 Up Lipogenesis 0.037920328 13 NaN FASN
imatinib Kinase inhibitor No MSN05 Up Lipogenesis 0.02559389 17.5 NaN FASN
imatinib Kinase inhibitor No MSN09 Up Lipogenesis 0.036362165 16 NaN FASN
imatinib Kinase inhibitor No MSN01 Up Metaphase to anaphase checkpoint 3.94E-05 3 NaN BUB1;BUB1B;CCNB2;CDC20;MXD3;PTTG1
imatinib Kinase inhibitor No MSN05 Up Metaphase to anaphase checkpoint 6.81E-05 4 NaN BUB1;CCNB2;CDC20;CENPE;PTTG1
imatinib Kinase inhibitor No MSN06 Up Metaphase to anaphase checkpoint 3.88E-06 3 NaN BUB1;BUB1B;CCNB2;CDC20;CENPE;MAD2L1;MXD3;PTTG1
imatinib Kinase inhibitor No MSN05 Up Mitochondrial ADP import and ATP export 0.012879323 14.5 NaN SLC25A5
imatinib Kinase inhibitor No MSN06 Up Mitochondrial ADP import and ATP export 0.02858151 24.5 NaN SLC25A5
imatinib Kinase inhibitor No MSN09 Down Mitochondrial fission 0.032966818 12.5 NaN DNM1;MTFP1
imatinib Kinase inhibitor No MSN06 Up Mitotic chromosome condensation 0.000743334 11 NaN INCENP;NCAPG2;SMC4
imatinib Kinase inhibitor No MSN05 Up Mitotic H3 phosphorylation and dephosphorylation 0.001606083 7 NaN AURKB;CCNA2
imatinib Kinase inhibitor No MSN06 Up Mitotic H3 phosphorylation and dephosphorylation 0.000221667 5.5 NaN AURKB;CCNA2;INCENP
imatinib Kinase inhibitor No MSN01 Up Mitotic spindle assembly 8.15E-05 5 NaN DLGAP5;NUSAP1;TACC3;TPX2
imatinib Kinase inhibitor No MSN05 Up Mitotic spindle assembly 1.73E-05 3 NaN DLGAP5;NUSAP1;TACC3;TPX2
imatinib Kinase inhibitor No MSN06 Up Mitotic spindle assembly 0.000381785 9 NaN DLGAP5;NUSAP1;TACC3;TPX2
imatinib Kinase inhibitor No MSN01 Up Mitotic spindle disassembly 0.019142555 12 NaN CDK1
imatinib Kinase inhibitor No MSN05 Up Mitotic spindle disassembly 0.012879323 14.5 NaN CDK1
imatinib Kinase inhibitor No MSN06 Up Mitotic spindle disassembly 0.02858151 24.5 NaN CDK1
imatinib Kinase inhibitor No MSN06 Down Neuregulin receptor signaling 0.000563125 2 NaN ERBB3;ERBB4;SH3TC2
imatinib Kinase inhibitor No MSN09 Down Neuronal membrane repolarization during action potential and hyperpolarization 0.010261464 6 NaN KCNA1;KCNC3;KCNQ3
imatinib Kinase inhibitor No MSN06 Up Osteonectin receptor signaling 0.004703576 16 NaN SMOC2;SPARC
imatinib Kinase inhibitor No MSN05 Down Osteonectin receptor signaling 0.006462844 9.5 NaN SMOC2;SPARC
imatinib Kinase inhibitor No MSN05 Down Osteopontin receptor signaling 0.033609739 18 NaN SPP1
imatinib Kinase inhibitor No MSN09 Down Osteopontin receptor signaling 0.024258998 10.5 NaN SPP1
imatinib Kinase inhibitor No MSN09 Up Phosphoglyceride biosynthesis 0.016525253 7 NaN PCYT2;PTDSS1
imatinib Kinase inhibitor No MSN01 Down PI3 kinase AKT signaling pathway 0.02679052 8.5 NaN FOXO1;INPP4B
imatinib Kinase inhibitor No MSN06 Up Platelet-derived growth factor receptor signaling 0.037774969 27 NaN PDGFRA;PDGFRB
imatinib Kinase inhibitor No MSN01 Down Platelet-derived growth factor receptor signaling 0.02679052 8.5 NaN PDGFRB;RGS5
imatinib Kinase inhibitor No MSN05 Down Progesterone receptor signaling 0.033609739 18 NaN PGR
imatinib Kinase inhibitor No MSN01 Down Prostaglandin PGF2 alpha receptor signaling 0.046898366 15.5 NaN PTGFR
imatinib Kinase inhibitor No MSN05 Up Protein folding in mitochondria 0.038145795 20 NaN PPIF
imatinib Kinase inhibitor No MSN06 Up Protein folding in mitochondria 0.002397082 13.5 NaN HSPD1;PPIF
imatinib Kinase inhibitor No MSN01 Down Removal of caspase inhibition 0.046898366 15.5 NaN XAF1
imatinib Kinase inhibitor No MSN09 Down Removal of caspase inhibition 0.047931585 16 NaN XAF1
imatinib Kinase inhibitor No MSN09 Down Restriction point 0.023204138 9 NaN E2F1;PFKFB3
imatinib Kinase inhibitor No MSN09 Up Retinol metabolism 0.02287923 11.5 NaN ALDH1A2;TTR
imatinib Kinase inhibitor No MSN01 Down Retinol metabolism 0.003167864 2 NaN ALDH1A1;RDH10;STRA6
imatinib Kinase inhibitor No MSN09 Down Retinol metabolism 0.000203815 3 NaN ALDH1A1;LRAT;RBP1;STRA6
imatinib Kinase inhibitor No MSN05 Up Ribonucleotide reduction 0.038145795 20 NaN RRM2
imatinib Kinase inhibitor No MSN06 Down Semaphorin signaling 0.015704931 6 NaN CRMP1;SEMA6A;SEMA6D
imatinib Kinase inhibitor No MSN01 Down Serine and glycine metabolism 0.001893039 1 NaN PHGDH;PSAT1;SHMT2
imatinib Kinase inhibitor No MSN06 Down Serine and glycine metabolism 1.74E-05 1 NaN PHGDH;PSAT1;SHMT2;SLC1A5
imatinib Kinase inhibitor No MSN09 Up Serotonin inactivation 0.036362165 16 NaN MAOA
imatinib Kinase inhibitor No MSN01 Down Serotonin inactivation 0.046898366 15.5 NaN MAOA
imatinib Kinase inhibitor No MSN01 Up Sister chromatid attachment to mitotic spindle 0.000364781 7 NaN NUF2;TACC3
imatinib Kinase inhibitor No MSN05 Up Sister chromatid attachment to mitotic spindle 0.02559389 17.5 NaN TACC3
imatinib Kinase inhibitor No MSN01 Up Sister chromatid segregation 0.000132602 6 NaN ESPL1;PTTG1;TOP2A
imatinib Kinase inhibitor No MSN05 Up Sister chromatid segregation 0.002388781 8.5 NaN PTTG1;TOP2A
imatinib Kinase inhibitor No MSN06 Up Sister chromatid segregation 0.000433942 10 NaN ESPL1;PTTG1;TOP2A
imatinib Kinase inhibitor No MSN09 Down Tenascin receptor signaling 0.003406483 5 NaN TENM1;TNC
imatinib Kinase inhibitor No MSN01 Up Thin myofilament organization 0.007189535 11 NaN TNNI3;TPM1
imatinib Kinase inhibitor No MSN05 Down Thin myofilament organization 0.021152788 13 NaN ACTA1;TPM4
imatinib Kinase inhibitor No MSN01 Down Thrombospondin receptor signaling 0.003261527 3 NaN THBS1;THBS2
imatinib Kinase inhibitor No MSN01 Down Tight junction organization 0.04605371 13 NaN CLDN6;EMP1;MPP5
imatinib Kinase inhibitor No MSN06 Up Transamination pathways 0.015551089 21.5 NaN GOT1;GOT2
imatinib Kinase inhibitor No MSN09 Up Transamination pathways 0.006621825 4 NaN GOT1;GOT2
imatinib Kinase inhibitor No MSN06 Up Tropoelastin synthesis 0.02858151 24.5 NaN ELN
imatinib Kinase inhibitor No MSN09 Up Tropoelastin synthesis 0.018348624 9 NaN ELN
imatinib Kinase inhibitor No MSN05 Down Tropoelastin synthesis 0.033609739 18 NaN ELN
imatinib Kinase inhibitor No MSN01 Down Urea cycle 0.007900936 4 NaN ARG2;ASS1
imatinib Kinase inhibitor No MSN09 Up Vasoactive intestinal peptide receptor signaling 0.036362165 16 NaN VIPR1
imatinib Kinase inhibitor No MSN09 Down Vasoactive intestinal peptide receptor signaling 0.047931585 16 NaN VIPR2
imatinib Kinase inhibitor No MSN06 Up Versican synthesis 0.02858151 24.5 NaN VCAN
imatinib Kinase inhibitor No MSN09 Down Vitamin K metabolism 0.024258998 10.5 NaN VKORC1
imatinib Kinase inhibitor No MSN05 Down WNT-Beta-catenin signaling pathway 0.001291241 6 NaN CTHRC1;DKK1;DKK2;FRZB;PAX6;SFRP2;SFRP4;WNT2
imatinib Kinase inhibitor No MSN06 Down WNT-Beta-catenin signaling pathway 0.003178244 3 NaN FZD1;FZD2;PAX6;SFRP2;WNT5A
imatinib Kinase inhibitor No MSN09 Down WNT-Beta-catenin signaling pathway 0.000147732 2 NaN APCDD1;DACT1;FZD2;FZD7;KREMEN1;PAX6;SFRP2;SFRP5
imatinib Kinase inhibitor No MSN06 Down Adherens junction organization 0.02585162 9 NaN ALCAM;CDH3;CTNNA3
imatinib Kinase inhibitor No MSN09 Up Aggrecan synthesis 0.018348624 9 NaN ACAN
imatinib Kinase inhibitor No MSN01 Down Albumin mediated blood protein transport 0.023729711 7 NaN ALB
imatinib Kinase inhibitor No MSN06 Up Alternative complement pathway 0.007691516 18.5 NaN C3;CFH
imatinib Kinase inhibitor No MSN06 Up Antigen presentation via MHC class I molecules 0.002390663 12 NaN HLA-A;HLA-B;HLA-C
imatinib Kinase inhibitor No MSN01 Down Aspartate and arginine metabolism 0.022263706 6 NaN ARG2;ASS1
imatinib Kinase inhibitor No MSN09 Up Biglycan synthesis 0.018348624 9 NaN BGN
imatinib Kinase inhibitor No MSN05 Down Biglycan synthesis 0.033609739 18 NaN BGN
imatinib Kinase inhibitor No MSN06 Down Cardiomyocyte repolarization during action potential and hyperpolarization 0.019502664 8 NaN KCND3;KCNQ5
imatinib Kinase inhibitor No MSN05 Down CCN intercellular signaling protein family receptor signaling 0.000358176 3 NaN CYR61;NOV;WISP1
imatinib Kinase inhibitor No MSN06 Down Cellular fatty acid uptake 0.030985506 10 NaN CD36
imatinib Kinase inhibitor No MSN09 Up Cellular iron uptake and export 0.02287923 11.5 NaN SLC39A14;TFRC
imatinib Kinase inhibitor No MSN01 Up Centrosome maturation 5.73E-05 4 NaN AURKA;CDC25B;PLK1;TPX2
imatinib Kinase inhibitor No MSN05 Up Centrosome maturation 0.000422825 5 NaN AURKA;PLK1;TPX2
imatinib Kinase inhibitor No MSN06 Up Centrosome maturation 0.000270376 7.5 NaN AURKA;CDC25B;PLK1;TPX2
imatinib Kinase inhibitor No MSN06 Up Centrosome organization 0.044652112 28 NaN ASPM;NEK2;POC1A;TACC3;WDR62
imatinib Kinase inhibitor No MSN01 Up Centrosome separation 9.05E-09 2 NaN AURKA;CCNB1;CDK1;ESPL1;NEK2;SPAG5
imatinib Kinase inhibitor No MSN05 Up Centrosome separation 8.29E-10 2 NaN AURKA;CCNB1;CDK1;KIF11;NEK2;SPAG5
imatinib Kinase inhibitor No MSN06 Up Centrosome separation 1.63E-09 2 NaN AURKA;CCNB1;CDK1;ESPL1;KIF11;NEK2;SPAG5
imatinib Kinase inhibitor No MSN01 Down Chaperone mediated protein folding in ER 0.01117202 5 NaN DNAJB9;ERO1A;ERO1B
imatinib Kinase inhibitor No MSN06 Down Chaperone mediated protein folding in ER 0.03831226 11.5 NaN DNAJB9;ERO1B
imatinib Kinase inhibitor No MSN01 Up Cholesterol synthesis 1.42E-14 1 NaN DHCR24;DHCR7;FDFT1;FDPS;HMGCR;HMGCS1;LSS;MVD;MVK;NSDHL;SQLE
imatinib Kinase inhibitor No MSN05 Up Cholesterol synthesis 1.68E-16 1 NaN CYP51A1;DHCR24;DHCR7;FDPS;HMGCR;HMGCS1;MSMO1;MVD;MVK;NSDHL;SQLE
imatinib Kinase inhibitor No MSN06 Up Cholesterol synthesis 6.11E-18 1 NaN CYP51A1;DHCR24;DHCR7;EBP;FDFT1;FDPS;HMGCR;HMGCS1;LSS;MSMO1;MVD;MVK;NSDHL;SQLE
imatinib Kinase inhibitor No MSN09 Up Cholesterol synthesis 5.49E-13 1 NaN CYP51A1;DHCR24;DHCR7;FDPS;HMGCR;HMGCS1;MSMO1;MVK;NSDHL;SQLE
imatinib Kinase inhibitor No MSN01 Up Cholesterol-sensitive control of SREBP activation 0.005200747 9 NaN INSIG1;SREBF1
imatinib Kinase inhibitor No MSN05 Up Cholesterol-sensitive control of SREBP activation 0.002388781 8.5 NaN INSIG1;SREBF1
imatinib Kinase inhibitor No MSN06 Up Cholesterol-sensitive control of SREBP activation 0.011320302 20 NaN INSIG1;SREBF1
imatinib Kinase inhibitor No MSN09 Up Cholesterol-sensitive control of SREBP activation 0.004787543 2.5 NaN INSIG1;SREBF1
imatinib Kinase inhibitor No MSN05 Down Collagen fiber crosslinking 0.010532622 11.5 NaN LOX;PXDN
imatinib Kinase inhibitor No MSN05 Down Collagen fibril organization by fibril-associated bridges 1.79E-05 2 NaN COL12A1;COL14A1;COL9A2;COL9A3
imatinib Kinase inhibitor No MSN06 Down Collagen fibril organization by fibril-associated bridges 0.003489434 4 NaN COL12A1;COL19A1
imatinib Kinase inhibitor No MSN09 Down Collagen fibril organization by fibril-associated bridges 0.00026753 4 NaN COL14A1;COL9A1;COL9A2
imatinib Kinase inhibitor No MSN06 Up Contractile ring constriction 0.000221667 5.5 NaN ANLN;ECT2;MYLK
imatinib Kinase inhibitor No MSN05 Down Decorin synthesis 0.033609739 18 NaN DCN
imatinib Kinase inhibitor No MSN05 Up Desaturation of fatty acids 0.003316081 10 NaN FADS2;SCD
imatinib Kinase inhibitor No MSN06 Up Desaturation of fatty acids 0.015551089 21.5 NaN FADS2;SCD
imatinib Kinase inhibitor No MSN05 Up Electron transport chain 0.00999102 12 NaN COX7A1;SDHA
imatinib Kinase inhibitor No MSN06 Up Endogenous control of complement activity 0.007691516 18.5 NaN CFH;CFI
imatinib Kinase inhibitor No MSN05 Down Endogenous control of complement activity 0.010532622 11.5 NaN CFH;CFI
imatinib Kinase inhibitor No MSN05 Down Epithelial intermediate filament dynamics 0.027583816 14.5 NaN KRT19;KRT7
imatinib Kinase inhibitor No MSN06 Up Equatorial RhoA activation 0.004703576 16 NaN ECT2;KIF23
idarubicin Anthracycline Yes MSN01 Up Acetylcholine-mediated control of postsynaptic potential 0.008950881 6.5 NaN AGRN;MUSK
idarubicin Anthracycline Yes MSN08 Up Actin filament severing and depolymerization 0.009710724 12.5 NaN LIMA1;LIMK2;TAGLN2
idarubicin Anthracycline Yes MSN08 Up Aggrecan synthesis 0.035462244 28 NaN ACAN
idarubicin Anthracycline Yes MSN08 Up Alternative complement pathway 0.01168318 14.5 NaN C1S;CFH
idarubicin Anthracycline Yes MSN01 Up Axonal intermediate filament dynamics 0.008950881 6.5 NaN NEFL;NES
idarubicin Anthracycline Yes MSN05 Up Bicarbonate transmembrane transport 0.011961902 5.5 NaN SLC26A3;SLC26A8;SLC4A10
idarubicin Anthracycline Yes MSN08 Up Bicarbonate transmembrane transport 0.02812372 22.5 NaN SLC26A8;SLC26A9;SLC4A10
idarubicin Anthracycline Yes MSN08 Up Biglycan synthesis 0.035462244 28 NaN BGN
idarubicin Anthracycline Yes MSN01 Up Calcitonin receptor signaling 0.042414608 19.5 NaN CALCB
idarubicin Anthracycline Yes MSN06 Up Calcitonin receptor signaling 0.044140376 10 NaN CALCB
idarubicin Anthracycline Yes MSN01 Down Cardiomyocyte repolarization during action potential and hyperpolarization 0.03648388 12.5 NaN KCNIP2;KCNQ5
idarubicin Anthracycline Yes MSN01 Up Cell cycle arrest in response to DNA damage 0.014121703 9.5 NaN BBC3;CDKN1A;MDM2
idarubicin Anthracycline Yes MSN05 Up Cell cycle arrest in response to DNA damage 0.00301256 4 NaN BBC3;CDKN1A;GADD45A;MDM2
idarubicin Anthracycline Yes MSN06 Up Cell cycle arrest in response to DNA damage 0.001810808 5 NaN BBC3;CDKN1A;GADD45A;MDM2
idarubicin Anthracycline Yes MSN01 Up Cellular cholesterol uptake and efflux 0.03055135 15.5 NaN ABCA12;MSR1
idarubicin Anthracycline Yes MSN05 Down Centrosome maturation 0.017179159 15.5 NaN PLK1;TPX2
idarubicin Anthracycline Yes MSN06 Down Centrosome maturation 0.028881222 18.5 NaN PLK1;TPX2
idarubicin Anthracycline Yes MSN08 Down Centrosome maturation 0.006300921 10.5 NaN PLK1;TPX2
idarubicin Anthracycline Yes MSN05 Down Centrosome separation 0.000541998 4 NaN CCNB1;CDK1;SPAG5
idarubicin Anthracycline Yes MSN06 Down Centrosome separation 2.44E-08 1 NaN CCNB1;CDK1;ESPL1;KIF11;NEK2;SPAG5
idarubicin Anthracycline Yes MSN08 Down Centrosome separation 2.01E-06 2 NaN CCNB1;CDK1;KIF11;SPAG5
idarubicin Anthracycline Yes MSN05 Down Chaperone-mediated autophagy 0.033935849 18.5 NaN HSPA8
idarubicin Anthracycline Yes MSN06 Down Chaperone-mediated autophagy 0.044657802 20.5 NaN HSPA8
idarubicin Anthracycline Yes MSN08 Down Chaperone-mediated autophagy 0.020187315 13.5 NaN HSPA8
idarubicin Anthracycline Yes MSN01 Up Chloride transmembrane transport 0.03055135 15.5 NaN CLCN5;SLC26A8
idarubicin Anthracycline Yes MSN05 Up Chloride transmembrane transport 0.042508252 10 NaN CFTR;SLC26A8
idarubicin Anthracycline Yes MSN08 Up Classical complement pathway 0.023405457 18.5 NaN C1R;C1S
idarubicin Anthracycline Yes MSN05 Up Coagulation cascade 0.036577041 9 NaN F11;KLKB1
idarubicin Anthracycline Yes MSN08 Up Coagulation cascade 3.53E-05 2 NaN F11;F2RL1;F5;KLKB1;TFPI
idarubicin Anthracycline Yes MSN08 Up Coagulation factor synthesis and vitamin K metabolism 0.01711611 16 NaN F11;F5
idarubicin Anthracycline Yes MSN08 Up Collagen fiber crosslinking 0.01168318 14.5 NaN LOX;PXDN
idarubicin Anthracycline Yes MSN01 Down Contractile ring constriction 0.004563637 2 NaN ANLN;MYH14
idarubicin Anthracycline Yes MSN05 Down Contractile ring constriction 0.002816438 9 NaN ANLN;MYH14
idarubicin Anthracycline Yes MSN06 Down Contractile ring constriction 0.004856492 9 NaN ANLN;MYH14
idarubicin Anthracycline Yes MSN08 Down Contractile ring constriction 0.001000091 6 NaN ANLN;MYH14
idarubicin Anthracycline Yes MSN06 Down Contractile ring formation 0.004856492 9 NaN MYH14;RACGAP1
idarubicin Anthracycline Yes MSN08 Down Contractile ring formation 0.001000091 6 NaN MYH14;RACGAP1
idarubicin Anthracycline Yes MSN08 Up Decorin synthesis 0.035462244 28 NaN DCN
idarubicin Anthracycline Yes MSN05 Up Desmosome organization 0.011961902 5.5 NaN DSG1;DSG3;DSG4
idarubicin Anthracycline Yes MSN08 Up Desmosome organization 0.02812372 22.5 NaN DSC3;DSG1;DSG3
idarubicin Anthracycline Yes MSN05 Down DNA replication elongation 4.81E-05 2 NaN MCM2;MCM5;MCM7
idarubicin Anthracycline Yes MSN06 Down DNA replication elongation 0.000110076 4 NaN MCM2;MCM5;MCM7
idarubicin Anthracycline Yes MSN08 Down DNA replication elongation 0.049713197 21.5 NaN MCM5
idarubicin Anthracycline Yes MSN05 Down DNA replication initiation 0.000793672 5 NaN MCM2;MCM5;MCM6;MCM7
idarubicin Anthracycline Yes MSN06 Down DNA replication initiation 0.000207233 6 NaN CDC6;GINS2;MCM2;MCM5;MCM7
idarubicin Anthracycline Yes MSN05 Up Drug and toxin export via membrane transport proteins 0.000979254 1 NaN ABCB1;ABCC11;ABCC3;ABCG8
idarubicin Anthracycline Yes MSN08 Up Drug and toxin export via membrane transport proteins 0.024307475 21 NaN ABCA1;ABCC3;ABCG8
idarubicin Anthracycline Yes MSN01 Up Eicosanoid metabolism 0.039992364 18 NaN CYP2J2;PTGS1
idarubicin Anthracycline Yes MSN01 Up Epithelial intermediate filament dynamics 0.011766804 8 NaN KRT19;KRT8
idarubicin Anthracycline Yes MSN08 Down Equatorial RhoA activation 0.039970575 18.5 NaN KIF23
idarubicin Anthracycline Yes MSN05 Down Eukaryotic kinetochore dynamics 0.000442261 3 NaN BUB1;CENPE;CENPF;CENPU;TTK
idarubicin Anthracycline Yes MSN06 Down Eukaryotic kinetochore dynamics 1.22E-07 2 NaN BUB1;CENPE;CENPF;CENPU;MAD2L1;MTUS2;NDC80;TTK;ZWINT
idarubicin Anthracycline Yes MSN08 Down Eukaryotic kinetochore dynamics 0.000568558 4 NaN BUB1;CENPE;CENPF;TTK
idarubicin Anthracycline Yes MSN01 Down Extracellular matrix breakdown and membrane shedding by adamalysins 0.014911907 5 NaN ADAM15;ADAMTS1;ADAMTS5
idarubicin Anthracycline Yes MSN05 Down Extracellular matrix breakdown and membrane shedding by adamalysins 4.55E-05 1 NaN ADAM12;ADAM15;ADAM19;ADAMTS1;ADAMTS14
idarubicin Anthracycline Yes MSN06 Down Extracellular matrix breakdown and membrane shedding by adamalysins 0.01622804 13 NaN ADAM15;ADAMTS1;ADAMTS14
idarubicin Anthracycline Yes MSN08 Up Extracellular matrix breakdown by heparanases and sulfatases 0.007177789 9.5 NaN SULF1;SULF2
idarubicin Anthracycline Yes MSN01 Up Extracellular matrix breakdown by matrix metalloproteases 0.000742746 2 NaN MMP1;MMP13;MMP2
idarubicin Anthracycline Yes MSN05 Up Extracellular matrix breakdown by matrix metalloproteases 0.001253764 2 NaN MMP1;MMP12;MMP13
idarubicin Anthracycline Yes MSN06 Up Extracellular matrix breakdown by meprins 0.044140376 10 NaN MEP1A
idarubicin Anthracycline Yes MSN08 Up Extracellular matrix breakdown by serine proteases 0.023405457 18.5 NaN HTRA1;PRSS12
idarubicin Anthracycline Yes MSN01 Up Extrinsic apoptosis pathway 0.000319501 1 NaN FAS;TNFRSF10A;TNFRSF10B
idarubicin Anthracycline Yes MSN05 Up Extrinsic apoptosis pathway 0.012663587 7 NaN FAS;TNFRSF10A
idarubicin Anthracycline Yes MSN06 Up Extrinsic apoptosis pathway 0.000359802 1 NaN FAS;TNFRSF10A;TNFRSF10B
idarubicin Anthracycline Yes MSN01 Up Fibrillar collagen core structure organization 0.018384589 11.5 NaN COL1A2;MMP13
idarubicin Anthracycline Yes MSN08 Up Fibrillar collagen core structure organization 7.33E-09 1 NaN COL11A1;COL1A1;COL1A2;COL3A1;COL5A1;COL5A2;COL5A3
idarubicin Anthracycline Yes MSN05 Down Fibrillin synthesis 0.000864304 6 NaN FBN1;FBN2
idarubicin Anthracycline Yes MSN05 Down Fibulin receptor signaling 0.033935849 18.5 NaN FBLN1
idarubicin Anthracycline Yes MSN01 Down Focal adhesion organization 0.012006745 4 NaN DLC1;LPP;RSU1;TLN2
idarubicin Anthracycline Yes MSN01 Down G2 M transition checkpoint 0.027228456 8.5 NaN CCNB1;WEE1
idarubicin Anthracycline Yes MSN05 Down G2 M transition checkpoint 0.017179159 15.5 NaN CCNB1;CDK1
idarubicin Anthracycline Yes MSN06 Down G2 M transition checkpoint 0.002153085 7 NaN CCNB1;CDK1;WEE1
idarubicin Anthracycline Yes MSN08 Down G2 M transition checkpoint 0.006300921 10.5 NaN CCNB1;CDK1
idarubicin Anthracycline Yes MSN01 Down Gap junction organization 0.03648388 12.5 NaN GJA1;GJA5
idarubicin Anthracycline Yes MSN01 Down Glutamate and glutamine metabolism 0.031721823 10.5 NaN SLC1A3;SLC1A5
idarubicin Anthracycline Yes MSN06 Up Glutamate-mediated control of postsynaptic potential 0.021644876 7 NaN GRIA1;GRID2;GRIN2B
idarubicin Anthracycline Yes MSN01 Down Granulocyte macrophage colony-stimulating factor receptor signaling 0.043277686 15 NaN JAK2
idarubicin Anthracycline Yes MSN05 Down Granulocyte macrophage colony-stimulating factor receptor signaling 0.033935849 18.5 NaN JAK2
idarubicin Anthracycline Yes MSN06 Down Granulocyte macrophage colony-stimulating factor receptor signaling 0.044657802 20.5 NaN JAK2
idarubicin Anthracycline Yes MSN08 Down Granulocyte macrophage colony-stimulating factor receptor signaling 0.020187315 13.5 NaN JAK2
idarubicin Anthracycline Yes MSN08 Up Growth differentiation factor receptor signaling 0.030483957 24 NaN GDF15;GDF6
idarubicin Anthracycline Yes MSN01 Up Histamine metabolism 0.042414608 19.5 NaN HDC
idarubicin Anthracycline Yes MSN08 Up Hyaluronan receptor CD44 signaling 0.003675108 6.5 NaN CD44;PTPRC
idarubicin Anthracycline Yes MSN06 Down Hyaluronan-mediated motility receptor signaling 0.022582922 14.5 NaN HMMR
idarubicin Anthracycline Yes MSN01 Up Inhibition of amyloid aggregation, amyloid degradation and uptake 0.001353509 4 NaN A2M;PLAT
idarubicin Anthracycline Yes MSN06 Up Inhibition of amyloid aggregation, amyloid degradation and uptake 0.001466565 3 NaN A2M;PLAT
idarubicin Anthracycline Yes MSN08 Up Inhibition of amyloid aggregation, amyloid degradation and uptake 4.43E-05 3 NaN A2M;MME;PLAT
idarubicin Anthracycline Yes MSN06 Up Inositol metabolism and transport 0.044140376 10 NaN INPP5D
idarubicin Anthracycline Yes MSN08 Up Integrin-mediated leukocyte rolling 0.023405457 18.5 NaN ICAM1;VCAM1
idarubicin Anthracycline Yes MSN06 Down Intracellular bridge abscission 0.024592889 17 NaN CEP55;EXOC6B;TEX14
idarubicin Anthracycline Yes MSN08 Down Intracellular bridge assembly 0.030128947 16.5 NaN KIF23
idarubicin Anthracycline Yes MSN01 Up Intrinsic apoptosis pathway 0.002972918 5 NaN BAK1;BAX;BBC3
idarubicin Anthracycline Yes MSN05 Up Intrinsic apoptosis pathway 0.04876973 12 NaN BAX;BBC3
idarubicin Anthracycline Yes MSN06 Up Intrinsic apoptosis pathway 0.003332429 6 NaN BAX;BBC3;BCL2L1
idarubicin Anthracycline Yes MSN01 Up JAK-STAT signaling pathway 0.035147755 17 NaN STAT1;USP18
idarubicin Anthracycline Yes MSN08 Down Leukocyte transmigration through endothelium 0.049713197 21.5 NaN MCAM
idarubicin Anthracycline Yes MSN05 Down Metaphase to anaphase checkpoint 0.002580751 8 NaN BUB1;CDC20;CENPE;TTK
idarubicin Anthracycline Yes MSN06 Down Metaphase to anaphase checkpoint 8.81E-06 3 NaN BUB1;BUB1B;CCNB2;CDC20;CENPE;MAD2L1;TTK
idarubicin Anthracycline Yes MSN08 Down Metaphase to anaphase checkpoint 1.02E-06 1 NaN BUB1;BUB1B;CCNB2;CDC20;CENPE;TTK
idarubicin Anthracycline Yes MSN08 Up Microfibril scaffold organization 0.001254553 5 NaN FBN1;MFAP2
idarubicin Anthracycline Yes MSN05 Down Microfibril scaffold organization 0.033935849 18.5 NaN FBN1
idarubicin Anthracycline Yes MSN06 Down Mitotic H3 phosphorylation and dephosphorylation 0.004856492 9 NaN AURKB;CCNA2
idarubicin Anthracycline Yes MSN08 Down Mitotic H3 phosphorylation and dephosphorylation 0.001000091 6 NaN AURKB;CCNA2
idarubicin Anthracycline Yes MSN01 Down Mitotic spindle assembly 0.031721823 10.5 NaN NUSAP1;TPX2
idarubicin Anthracycline Yes MSN05 Down Mitotic spindle assembly 0.001243697 7 NaN NUSAP1;TPX2;TTK
idarubicin Anthracycline Yes MSN06 Down Mitotic spindle assembly 0.000154691 5 NaN DLGAP5;NUSAP1;TPX2;TTK
idarubicin Anthracycline Yes MSN08 Down Mitotic spindle assembly 6.70E-06 3 NaN DLGAP5;NUSAP1;TPX2;TTK
idarubicin Anthracycline Yes MSN01 Down Z-disc organization 0.004691376 3 NaN ACTN2;LDB3;PDLIM5
idarubicin Anthracycline Yes MSN06 Down Z-disc organization 0.049507089 22 NaN ACTN2;PDLIM5
idarubicin Anthracycline Yes MSN05 Down Mitotic spindle disassembly 0.01711362 13 NaN CDK1
idarubicin Anthracycline Yes MSN06 Down Mitotic spindle disassembly 0.022582922 14.5 NaN CDK1
idarubicin Anthracycline Yes MSN08 Down Mitotic spindle disassembly 0.010144672 12 NaN CDK1
idarubicin Anthracycline Yes MSN01 Down Myofibril formation 0.01910546 6 NaN PDLIM5;TMOD1
idarubicin Anthracycline Yes MSN05 Down Natriuretic peptide receptor signaling 0.004177141 10 NaN NPPA;NPPB
idarubicin Anthracycline Yes MSN01 Up Necroptosis induction 0.021436133 13.5 NaN TNFRSF1A
idarubicin Anthracycline Yes MSN06 Down Neuregulin receptor signaling 0.024426533 16 NaN ERBB3;ERBB4
idarubicin Anthracycline Yes MSN08 Down Neuregulin receptor signaling 0.005285654 9 NaN ERBB3;ERBB4
idarubicin Anthracycline Yes MSN08 Up Notch receptor signaling 0.032238557 25 NaN DLK1;JAG1;NOTCH3
idarubicin Anthracycline Yes MSN01 Up Nucleotide excision repair 0.001323288 3 NaN DDB2;PCNA;POLH;XPC
idarubicin Anthracycline Yes MSN06 Up Nucleotide excision repair 0.001535642 4 NaN DDB2;PCNA;POLH;XPC
idarubicin Anthracycline Yes MSN08 Up Osteonectin receptor signaling 0.007177789 9.5 NaN SMOC2;SPARC
idarubicin Anthracycline Yes MSN08 Up Osteopontin receptor signaling 0.035462244 28 NaN SPP1
idarubicin Anthracycline Yes MSN05 Down Osteopontin receptor signaling 0.01711362 13 NaN SPP1
idarubicin Anthracycline Yes MSN08 Up Polyol pathway 0.007177789 9.5 NaN AKR1B1;AKR1B10
idarubicin Anthracycline Yes MSN01 Up Potassium transmembrane transport 0.014121703 9.5 NaN SLC12A1;SLC12A4;SLC24A4
idarubicin Anthracycline Yes MSN08 Down Potassium transmembrane transport 0.024346481 15 NaN ATP1A3;FXYD1
idarubicin Anthracycline Yes MSN08 Up Procollagen processing in the ER 0.003675108 6.5 NaN P3H1;PPIB
idarubicin Anthracycline Yes MSN08 Up Ras signaling pathway 0.009710724 12.5 NaN KSR1;KSR2;SHC1
idarubicin Anthracycline Yes MSN01 Down Recycling endosome dynamics 0.022644486 7 NaN ASAP1;KIF13A;SNAP23
idarubicin Anthracycline Yes MSN01 Up RNA editing 0.018384589 11.5 NaN APOBEC2;APOBEC3C
idarubicin Anthracycline Yes MSN05 Up RNA editing 0.001757209 3 NaN A1CF;APOBEC2;APOBEC3H
idarubicin Anthracycline Yes MSN06 Up RNA editing 0.001173699 2 NaN APOBEC2;APOBEC3C;APOBEC3H
idarubicin Anthracycline Yes MSN08 Up Selectin-mediated Leukocyte rolling 0.00081732 4 NaN ICAM1;SELP;VCAM1
idarubicin Anthracycline Yes MSN01 Down Semaphorin signaling 0.037609535 14 NaN NRP1;PLXNA4;SEMA5A
idarubicin Anthracycline Yes MSN06 Down Sister chromatid segregation 0.007176501 11 NaN ESPL1;TOP2A
idarubicin Anthracycline Yes MSN05 Up Sodium transmembrane transport 0.048020416 11 NaN SCN3A;SCNN1A;SLC13A1
idarubicin Anthracycline Yes MSN08 Up Tenascin receptor signaling 0.007177789 9.5 NaN TNC;TNR
idarubicin Anthracycline Yes MSN01 Down Thick myofilament organization 0.001409479 1 NaN MYH7;TTN
idarubicin Anthracycline Yes MSN08 Down Thick myofilament organization 0.030128947 16.5 NaN MYH7
idarubicin Anthracycline Yes MSN05 Down Thin myofilament organization 0.005782315 11 NaN ACTA1;TNNI3
idarubicin Anthracycline Yes MSN06 Down Thin myofilament organization 0.009898099 12 NaN ACTA1;TNNI3
idarubicin Anthracycline Yes MSN08 Down Thin myofilament organization 0.002072439 8 NaN ACTA1;TNNI3
idarubicin Anthracycline Yes MSN08 Down Thrombopoietin receptor signaling 0.039970575 18.5 NaN JAK2
idarubicin Anthracycline Yes MSN08 Up Thyroid-hormone synthesis 0.023405457 18.5 NaN IYD;TG
idarubicin Anthracycline Yes MSN06 Up Tight junction organization 0.039540041 8 NaN CLDN1;F11R;MYLK
idarubicin Anthracycline Yes MSN08 Down Tight junction organization 0.046359007 20 NaN CLDN6;CRB2
idarubicin Anthracycline Yes MSN01 Up Tropoelastin synthesis 0.021436133 13.5 NaN ELN
idarubicin Anthracycline Yes MSN08 Up Tropoelastin synthesis 0.035462244 28 NaN ELN
idarubicin Anthracycline Yes MSN05 Down Tropoelastin synthesis 0.01711362 13 NaN ELN
idarubicin Anthracycline Yes MSN01 Down Vesicle tethering at plasma membrane 0.027228456 8.5 NaN EXOC6B;RHOQ
idarubicin Anthracycline Yes MSN06 Down Vesicle tethering at plasma membrane 0.028881222 18.5 NaN EXOC6B;RHOQ
idarubicin Anthracycline Yes MSN05 Up Water transmembrane transport 0.016600789 8 NaN AQP4;AQP9
gefitinib Kinase inhibitor No MSN01 Down Mitotic spindle disassembly 0.02664079 21 NaN CDK1
gefitinib Kinase inhibitor No MSN06 Down Mitotic spindle disassembly 0.028757939 24.5 NaN CDK1
gefitinib Kinase inhibitor No MSN08 Down Mitotic spindle disassembly 0.02858151 25 NaN CDK1
gefitinib Kinase inhibitor No MSN09 Down Mitotic spindle disassembly 0.027699365 27.5 NaN CDK1
gefitinib Kinase inhibitor No MSN01 Down Natriuretic peptide receptor signaling 0.009884567 14.5 NaN NPPA;NPPB
gefitinib Kinase inhibitor No MSN05 Down Natriuretic peptide receptor signaling 0.010986142 22.5 NaN NPPA;NPPB
gefitinib Kinase inhibitor No MSN06 Down Natriuretic peptide receptor signaling 0.011455252 17.5 NaN NPPA;NPPB
gefitinib Kinase inhibitor No MSN08 Down Natriuretic peptide receptor signaling 0.011320302 17.5 NaN NPPA;NPPB
gefitinib Kinase inhibitor No MSN09 Down Natriuretic peptide receptor signaling 0.010656589 20.5 NaN NPPA;NPPB
gefitinib Kinase inhibitor No MSN01 Up Osteonectin receptor signaling 0.002114306 1 NaN SMOC2;SPARC
gefitinib Kinase inhibitor No MSN01 Down Osteopontin receptor signaling 0.02664079 21 NaN SPP1
gefitinib Kinase inhibitor No MSN06 Down Osteopontin receptor signaling 0.028757939 24.5 NaN SPP1
gefitinib Kinase inhibitor No MSN08 Down Osteopontin receptor signaling 0.02858151 25 NaN SPP1
gefitinib Kinase inhibitor No MSN09 Down Osteopontin receptor signaling 0.027699365 27.5 NaN SPP1
gefitinib Kinase inhibitor No MSN05 Up Progesterone receptor signaling 0.018613267 8.5 NaN PGR
gefitinib Kinase inhibitor No MSN08 Up Protein polyubiquitination 0.031304625 7 NaN ISG15;UCHL1
gefitinib Kinase inhibitor No MSN01 Down Pyrimidine synthesis and salvage 0.017812077 18 NaN TK1;TYMS
gefitinib Kinase inhibitor No MSN05 Down Pyrimidine synthesis and salvage 0.01975769 27.5 NaN TK1;TYMS
gefitinib Kinase inhibitor No MSN06 Down Pyrimidine synthesis and salvage 0.020584442 21.5 NaN TK1;TYMS
gefitinib Kinase inhibitor No MSN08 Down Pyrimidine synthesis and salvage 0.020346716 21.5 NaN TK1;TYMS
gefitinib Kinase inhibitor No MSN09 Down Pyrimidine synthesis and salvage 0.019176257 24.5 NaN TK1;TYMS
gefitinib Kinase inhibitor No MSN01 Up Removal of caspase inhibition 0.037747261 8.5 NaN XAF1
gefitinib Kinase inhibitor No MSN01 Down Retinol metabolism 0.045465381 27 NaN ALDH1A1;ALDH1A3
gefitinib Kinase inhibitor No MSN05 Down Retinol metabolism 0.000359811 7 NaN ALDH1A1;ALDH1A3;RLBP1;RPE65
gefitinib Kinase inhibitor No MSN06 Down Retinol metabolism 0.000390839 7 NaN ALDH1A1;ALDH1A3;RLBP1;RPE65
gefitinib Kinase inhibitor No MSN08 Down Retinol metabolism 0.005346195 14 NaN ALDH1A1;ALDH1A3;RPE65
gefitinib Kinase inhibitor No MSN09 Down Retinol metabolism 0.004897419 18 NaN ALDH1A1;ALDH1A3;RPE65
gefitinib Kinase inhibitor No MSN01 Up Semaphorin signaling 0.026457494 6 NaN NRP2;RND1;SEMA6A
gefitinib Kinase inhibitor No MSN05 Up Semaphorin signaling 0.003492829 2 NaN NRP2;RND1;SEMA6A;SEMA6D
gefitinib Kinase inhibitor No MSN06 Up Semaphorin signaling 0.002580751 3 NaN NRP2;RND1;SEMA6A;SEMA6D
gefitinib Kinase inhibitor No MSN08 Up Semaphorin signaling 0.002829489 3 NaN NRP2;RND1;SEMA6A;SEMA6D
gefitinib Kinase inhibitor No MSN09 Up Semaphorin signaling 0.003433854 2 NaN NRP2;RND1;SEMA6A;SEMA6D
gefitinib Kinase inhibitor No MSN05 Up Serine and glycine metabolism 0.016979566 7 NaN PHGDH;PSAT1
gefitinib Kinase inhibitor No MSN06 Up Serine and glycine metabolism 0.000735879 2 NaN PHGDH;PSAT1;SHMT2
gefitinib Kinase inhibitor No MSN08 Up Serine and glycine metabolism 0.000792452 2 NaN PHGDH;PSAT1;SHMT2
gefitinib Kinase inhibitor No MSN09 Up Serine and glycine metabolism 0.016827526 6 NaN PHGDH;PSAT1
gefitinib Kinase inhibitor No MSN01 Down Sister chromatid attachment to mitotic spindle 0.000707444 9 NaN NUF2;TACC3
gefitinib Kinase inhibitor No MSN05 Down Sister chromatid attachment to mitotic spindle 0.000789471 10.5 NaN NUF2;TACC3
gefitinib Kinase inhibitor No MSN06 Down Sister chromatid attachment to mitotic spindle 0.000824555 9.5 NaN NUF2;TACC3
gefitinib Kinase inhibitor No MSN09 Down Sister chromatid attachment to mitotic spindle 0.000764879 10.5 NaN NUF2;TACC3
gefitinib Kinase inhibitor No MSN01 Down Sister chromatid segregation 0.00035274 7 NaN ESPL1;PTTG1;TOP2A
gefitinib Kinase inhibitor No MSN05 Down Sister chromatid segregation 0.000414519 8 NaN ESPL1;PTTG1;TOP2A
gefitinib Kinase inhibitor No MSN06 Down Sister chromatid segregation 0.000441875 8 NaN ESPL1;PTTG1;TOP2A
gefitinib Kinase inhibitor No MSN08 Down Sister chromatid segregation 0.000433942 5 NaN ESPL1;PTTG1;TOP2A
gefitinib Kinase inhibitor No MSN09 Down Sister chromatid segregation 0.000395672 8 NaN ESPL1;PTTG1;TOP2A
gefitinib Kinase inhibitor No MSN01 Down Syndecan receptor signaling 0.006707292 12 NaN SDC1;SDC3
gefitinib Kinase inhibitor No MSN05 Down Tenascin receptor signaling 0.00456203 17.5 NaN TENM1;TNC
gefitinib Kinase inhibitor No MSN06 Down Tenascin receptor signaling 0.004760776 15.5 NaN TENM1;TNC
gefitinib Kinase inhibitor No MSN08 Down Tenascin receptor signaling 0.004703576 12.5 NaN TENM1;TNC
gefitinib Kinase inhibitor No MSN09 Down Tenascin receptor signaling 0.004422563 16 NaN TENM1;TNC
gefitinib Kinase inhibitor No MSN05 Down Thrombospondin receptor signaling 0.00456203 17.5 NaN THBS1;THBS4
gefitinib Kinase inhibitor No MSN08 Down Thrombospondin receptor signaling 0.004703576 12.5 NaN THBS1;THBS4
gefitinib Kinase inhibitor No MSN05 Down Transmembrane glucose transport 0.00456203 17.5 NaN SLC2A1;SLC2A3
gefitinib Kinase inhibitor No MSN09 Down Transmembrane glucose transport 0.004422563 16 NaN SLC2A1;SLC2A3
gefitinib Kinase inhibitor No MSN01 Down Tropoelastin synthesis 0.02664079 21 NaN ELN
gefitinib Kinase inhibitor No MSN06 Down Tropoelastin synthesis 0.028757939 24.5 NaN ELN
gefitinib Kinase inhibitor No MSN09 Down Tropoelastin synthesis 0.027699365 27.5 NaN ELN
gefitinib Kinase inhibitor No MSN01 Down Versican synthesis 0.02664079 21 NaN VCAN
gefitinib Kinase inhibitor No MSN06 Down Versican synthesis 0.028757939 24.5 NaN VCAN
gefitinib Kinase inhibitor No MSN08 Down Versican synthesis 0.02858151 25 NaN VCAN
gefitinib Kinase inhibitor No MSN09 Down Versican synthesis 0.027699365 27.5 NaN VCAN
gefitinib Kinase inhibitor No MSN01 Up Water transmembrane transport 0.009381839 2 NaN AQP3;AQP7
gefitinib Kinase inhibitor No MSN05 Up Water transmembrane transport 0.008967419 4 NaN AQP3;AQP7
gefitinib Kinase inhibitor No MSN09 Up Water transmembrane transport 0.008885569 4 NaN AQP3;AQP7
gefitinib Kinase inhibitor No MSN09 Up WNT-Beta-catenin signaling pathway 0.030670085 9 NaN DKK2;FZD1;SFRP4;WNT2
gefitinib Kinase inhibitor No MSN01 Down Eukaryotic kinetochore dynamics 4.96E-07 2 NaN BUB1;CENPE;CENPF;CENPU;NDC80;NUF2;SPC24;TTK;ZWINT
gefitinib Kinase inhibitor No MSN05 Down Eukaryotic kinetochore dynamics 8.43E-06 2 NaN BUB1;CENPE;CENPF;NDC80;NUF2;SPC24;TTK;ZWINT
gefitinib Kinase inhibitor No MSN06 Down Eukaryotic kinetochore dynamics 9.88E-06 2 NaN BUB1;CENPE;CENPF;NDC80;NUF2;SPC24;TTK;ZWINT
gefitinib Kinase inhibitor No MSN08 Down Eukaryotic kinetochore dynamics 0.000663612 6 NaN BUB1;CENPE;CENPF;NDC80;SPC24;ZWINT
gefitinib Kinase inhibitor No MSN09 Down Eukaryotic kinetochore dynamics 7.51E-06 2 NaN BUB1;CENPE;CENPF;NDC80;NUF2;SPC24;TTK;ZWINT
gefitinib Kinase inhibitor No MSN05 Up Extracellular matrix breakdown and membrane shedding by adamalysins 0.009644999 5 NaN ADAM33;ADAMTS2;ADAMTS5
gefitinib Kinase inhibitor No MSN06 Up Extracellular matrix breakdown and membrane shedding by adamalysins 0.007665244 6 NaN ADAM33;ADAMTS2;ADAMTS5
gefitinib Kinase inhibitor No MSN08 Up Extracellular matrix breakdown and membrane shedding by adamalysins 0.008219515 5 NaN ADAM33;ADAMTS2;ADAMTS5
gefitinib Kinase inhibitor No MSN09 Up Extracellular matrix breakdown and membrane shedding by adamalysins 0.009521023 5 NaN ADAM33;ADAMTS2;ADAMTS5
gefitinib Kinase inhibitor No MSN06 Down Extracellular matrix breakdown by cathepsins 0.031852436 28 NaN CTSB;CTSV
gefitinib Kinase inhibitor No MSN05 Up Extracellular matrix breakdown by matrix metalloproteases 0.011389077 6 NaN MMP14;MMP2
gefitinib Kinase inhibitor No MSN05 Down Extracellular matrix breakdown by matrix metalloproteases 0.024935716 29 NaN MMP12;MMP3
gefitinib Kinase inhibitor No MSN08 Down Extracellular matrix breakdown by matrix metalloproteases 0.025671642 23 NaN MMP1;MMP12
gefitinib Kinase inhibitor No MSN01 Up Fibrillar collagen core structure organization 0.01470451 3 NaN COL5A1;COL5A2
gefitinib Kinase inhibitor No MSN06 Up Fibrillar collagen core structure organization 0.000541998 1 NaN COL1A1;COL5A1;COL5A2
gefitinib Kinase inhibitor No MSN01 Down Fibrillar collagen core structure organization 0.027639392 24 NaN COL11A1;COL2A1
gefitinib Kinase inhibitor No MSN06 Down Fibrillar collagen core structure organization 0.031852436 28 NaN COL11A1;COL2A1
gefitinib Kinase inhibitor No MSN08 Down Fibrillar collagen core structure organization 0.031491887 27.5 NaN COL11A1;COL2A1
gefitinib Kinase inhibitor No MSN09 Down Fibrillar collagen core structure organization 0.029714771 30 NaN COL11A1;COL2A1
gefitinib Kinase inhibitor No MSN01 Down G2 M transition checkpoint 0.039146161 25.5 NaN CCNB1;CDK1
gefitinib Kinase inhibitor No MSN06 Down G2 M transition checkpoint 0.044988879 30 NaN CCNB1;CDK1
gefitinib Kinase inhibitor No MSN08 Down G2 M transition checkpoint 0.044489851 29 NaN CCNB1;CDK1
gefitinib Kinase inhibitor No MSN05 Down GABA metabolism 0.010986142 22.5 NaN ABAT;SLC6A1
gefitinib Kinase inhibitor No MSN01 Up Gap junction organization 0.028287811 7 NaN GJA5;GJB2
gefitinib Kinase inhibitor No MSN05 Up Gap junction organization 0.027085315 11 NaN GJA5;GJB2
gefitinib Kinase inhibitor No MSN06 Up Gap junction organization 0.023162096 8 NaN GJA5;GJB2
gefitinib Kinase inhibitor No MSN09 Up Gap junction organization 0.026847432 8 NaN GJA5;GJB2
gefitinib Kinase inhibitor No MSN05 Up Glutamate and glutamine metabolism 0.023500077 10 NaN SLC1A3;SLC7A5
gefitinib Kinase inhibitor No MSN05 Down Glycolysis and Gluconeogenesis 0.003568606 14 NaN ENO1;LDHA;PGAM1;TPI1
gefitinib Kinase inhibitor No MSN06 Down Glycolysis and Gluconeogenesis 0.003857319 13 NaN ENO1;LDHA;PGAM1;TPI1
gefitinib Kinase inhibitor No MSN08 Down Glycolysis and Gluconeogenesis 0.003773255 10 NaN ENO1;LDHA;PGAM1;TPI1
gefitinib Kinase inhibitor No MSN09 Down Glycolysis and Gluconeogenesis 0.003371709 13 NaN ENO1;LDHA;PGAM1;TPI1
gefitinib Kinase inhibitor No MSN01 Up Hedgehog receptor signaling 0.049963218 10 NaN CDON;GAS1
gefitinib Kinase inhibitor No MSN05 Up Hedgehog receptor signaling 0.047907402 13 NaN CDON;GAS1
gefitinib Kinase inhibitor No MSN06 Up Hedgehog receptor signaling 0.041167145 10 NaN CDON;GAS1
gefitinib Kinase inhibitor No MSN08 Up Hedgehog receptor signaling 0.043108677 8 NaN CDON;GAS1
gefitinib Kinase inhibitor No MSN09 Up Hedgehog receptor signaling 0.047500161 11 NaN CDON;GAS1
gefitinib Kinase inhibitor No MSN05 Up Hepatocyte growth factor receptor signaling 0.036881693 12 NaN HGF
gefitinib Kinase inhibitor No MSN06 Up Hepatocyte growth factor receptor signaling 0.033935849 9 NaN HGF
gefitinib Kinase inhibitor No MSN01 Up Inhibition of apoptosis 0.021034131 5 NaN IFI6;XAF1
gefitinib Kinase inhibitor No MSN01 Down Intracellular bridge assembly 0.002084881 10 NaN INCENP;KIF23
gefitinib Kinase inhibitor No MSN05 Down Intracellular bridge assembly 0.002324253 13 NaN INCENP;KIF23
gefitinib Kinase inhibitor No MSN06 Down Intracellular bridge assembly 0.002426522 12 NaN INCENP;KIF23
gefitinib Kinase inhibitor No MSN08 Down Intracellular bridge assembly 0.002397082 8 NaN INCENP;KIF23
gefitinib Kinase inhibitor No MSN09 Down Intracellular bridge assembly 0.002252526 12 NaN INCENP;KIF23
gefitinib Kinase inhibitor No MSN05 Down Lipogenesis 0.000789471 10.5 NaN ACLY;FASN
gefitinib Kinase inhibitor No MSN06 Down Lipogenesis 0.000824555 9.5 NaN ACLY;FASN
gefitinib Kinase inhibitor No MSN09 Down Lipogenesis 0.000764879 10.5 NaN ACLY;FASN
gefitinib Kinase inhibitor No MSN01 Down Metaphase to anaphase checkpoint 2.30E-06 3 NaN BUB1;BUB1B;CCNB2;CDC20;CENPE;PLK3;PTTG1;TTK
gefitinib Kinase inhibitor No MSN05 Down Metaphase to anaphase checkpoint 3.66E-05 4 NaN BUB1;BUB1B;CCNB2;CDC20;CENPE;PTTG1;TTK
gefitinib Kinase inhibitor No MSN06 Down Metaphase to anaphase checkpoint 4.20E-05 4 NaN BUB1;BUB1B;CCNB2;CDC20;CENPE;PTTG1;TTK
gefitinib Kinase inhibitor No MSN08 Down Metaphase to anaphase checkpoint 0.000355871 3 NaN BUB1;CCNB2;CDC20;CENPE;PLK3;PTTG1
gefitinib Kinase inhibitor No MSN09 Down Metaphase to anaphase checkpoint 3.31E-05 4 NaN BUB1;BUB1B;CCNB2;CDC20;CENPE;PTTG1;TTK
gefitinib Kinase inhibitor No MSN01 Down Mitotic H3 phosphorylation and dephosphorylation 0.000179921 5.5 NaN AURKB;CCNA2;INCENP
gefitinib Kinase inhibitor No MSN05 Down Mitotic H3 phosphorylation and dephosphorylation 0.000211674 5.5 NaN AURKB;CCNA2;INCENP
gefitinib Kinase inhibitor No MSN06 Down Mitotic H3 phosphorylation and dephosphorylation 0.000225749 5.5 NaN AURKB;CCNA2;INCENP
gefitinib Kinase inhibitor No MSN08 Down Mitotic H3 phosphorylation and dephosphorylation 0.000221667 2 NaN AURKB;CCNA2;INCENP
gefitinib Kinase inhibitor No MSN09 Down Mitotic H3 phosphorylation and dephosphorylation 0.000201982 6.5 NaN AURKB;CCNA2;INCENP
gefitinib Kinase inhibitor No MSN01 Down Mitotic spindle assembly 1.40E-05 4 NaN DLGAP5;NUSAP1;TACC3;TPX2;TTK
gefitinib Kinase inhibitor No MSN05 Down Mitotic spindle assembly 1.83E-05 3 NaN DLGAP5;NUSAP1;TACC3;TPX2;TTK
gefitinib Kinase inhibitor No MSN06 Down Mitotic spindle assembly 2.03E-05 3 NaN DLGAP5;NUSAP1;TACC3;TPX2;TTK
gefitinib Kinase inhibitor No MSN08 Down Mitotic spindle assembly 0.000381785 4 NaN DLGAP5;NUSAP1;TACC3;TPX2
gefitinib Kinase inhibitor No MSN09 Down Mitotic spindle assembly 1.69E-05 3 NaN DLGAP5;NUSAP1;TACC3;TPX2;TTK
gefitinib Kinase inhibitor No MSN01 Up Albumin mediated blood protein transport 0.01905434 4 NaN ALB
gefitinib Kinase inhibitor No MSN05 Up Alternative complement pathway 6.19E-05 1 NaN C1S;C3;CFH
gefitinib Kinase inhibitor No MSN06 Up Alternative complement pathway 0.002816438 4 NaN C1S;CFH
gefitinib Kinase inhibitor No MSN08 Up Alternative complement pathway 5.19E-05 1 NaN C1S;C3;CFH
gefitinib Kinase inhibitor No MSN09 Up Alternative complement pathway 6.10E-05 1 NaN C1S;C3;CFH
gefitinib Kinase inhibitor No MSN01 Up Androgen receptor signaling 0.037747261 8.5 NaN AR
gefitinib Kinase inhibitor No MSN09 Up Androgen receptor signaling 0.036708532 10 NaN AR
gefitinib Kinase inhibitor No MSN06 Down Antigen presentation via MHC class I molecules 0.031852436 28 NaN HLA-B;HLA-C
gefitinib Kinase inhibitor No MSN08 Down Antigen presentation via MHC class I molecules 0.031491887 27.5 NaN HLA-B;HLA-C
gefitinib Kinase inhibitor No MSN01 Down Axonal intermediate filament dynamics 0.013596343 16.5 NaN NEFM;NES
gefitinib Kinase inhibitor No MSN08 Down Axonal intermediate filament dynamics 0.015551089 19.5 NaN NEFM;NES
gefitinib Kinase inhibitor No MSN01 Down Biglycan synthesis 0.02664079 21 NaN BGN
gefitinib Kinase inhibitor No MSN08 Down CCN intercellular signaling protein family receptor signaling 0.007691516 15.5 NaN CTGF;CYR61
gefitinib Kinase inhibitor No MSN01 Down Centrosome maturation 0.039146161 25.5 NaN PLK1;TPX2
gefitinib Kinase inhibitor No MSN05 Down Centrosome maturation 0.004020563 15 NaN AURKA;PLK1;TPX2
gefitinib Kinase inhibitor No MSN06 Down Centrosome maturation 0.004273932 14 NaN AURKA;PLK1;TPX2
gefitinib Kinase inhibitor No MSN08 Down Centrosome maturation 0.004200562 11 NaN AURKA;PLK1;TPX2
gefitinib Kinase inhibitor No MSN09 Down Centrosome maturation 0.003845422 14 NaN AURKA;PLK1;TPX2
gefitinib Kinase inhibitor No MSN01 Down Centrosome organization 0.009332058 13 NaN ASPM;NEK2;PAX6;PLK3;TACC3;WDR62
gefitinib Kinase inhibitor No MSN05 Down Centrosome organization 0.012010543 25 NaN ASPM;NEK2;PAX6;TACC3;TUBG1;WDR62
gefitinib Kinase inhibitor No MSN06 Down Centrosome organization 0.013257546 19 NaN ASPM;NEK2;PAX6;TACC3;TUBG1;WDR62
gefitinib Kinase inhibitor No MSN08 Down Centrosome organization 0.003177341 9 NaN ASPM;NEK2;PAX6;PLK3;TACC3;TUBG1;WDR62
gefitinib Kinase inhibitor No MSN09 Down Centrosome organization 0.011172389 22 NaN ASPM;NEK2;PAX6;TACC3;TUBG1;WDR62
gefitinib Kinase inhibitor No MSN01 Down Centrosome separation 6.53E-08 1 NaN CCNB1;CDK1;ESPL1;KIF11;NEK2;SPAG5
gefitinib Kinase inhibitor No MSN05 Down Centrosome separation 1.46E-09 1 NaN AURKA;CCNB1;CDK1;ESPL1;KIF11;NEK2;SPAG5
gefitinib Kinase inhibitor No MSN06 Down Centrosome separation 1.70E-09 1 NaN AURKA;CCNB1;CDK1;ESPL1;KIF11;NEK2;SPAG5
gefitinib Kinase inhibitor No MSN08 Down Centrosome separation 9.93E-08 1 NaN AURKA;CCNB1;CDK1;ESPL1;NEK2;SPAG5
gefitinib Kinase inhibitor No MSN09 Down Centrosome separation 1.31E-09 1 NaN AURKA;CCNB1;CDK1;ESPL1;KIF11;NEK2;SPAG5
gefitinib Kinase inhibitor No MSN05 Down Cholesterol synthesis 0.002086621 12 NaN DHCR24;DHCR7;MVK;NSDHL
gefitinib Kinase inhibitor No MSN06 Down Cholesterol synthesis 0.002258742 11 NaN DHCR24;DHCR7;MVK;NSDHL
gefitinib Kinase inhibitor No MSN08 Down Cholesterol synthesis 0.002208592 7 NaN DHCR24;DHCR7;MVK;NSDHL
gefitinib Kinase inhibitor No MSN09 Down Cholesterol synthesis 0.000173848 5 NaN DHCR24;DHCR7;MSMO1;MVK;NSDHL
gefitinib Kinase inhibitor No MSN05 Down Cholesterol-sensitive control of SREBP activation 0.010986142 22.5 NaN INSIG1;SREBF1
gefitinib Kinase inhibitor No MSN05 Up Classical complement pathway 0.006808638 3 NaN C1R;C1S
gefitinib Kinase inhibitor No MSN06 Up Classical complement pathway 0.005782315 5 NaN C1R;C1S
gefitinib Kinase inhibitor No MSN08 Up Classical complement pathway 0.006076013 4 NaN C1R;C1S
gefitinib Kinase inhibitor No MSN09 Up Classical complement pathway 0.006746097 3 NaN C1R;C1S
gefitinib Kinase inhibitor No MSN05 Down Collagen fiber crosslinking 0.007462268 20 NaN LOXL1;PLOD1
gefitinib Kinase inhibitor No MSN09 Down Collagen fiber crosslinking 0.007236283 19 NaN LOXL1;PLOD1
gefitinib Kinase inhibitor No MSN01 Down Collagen fibril organization by fibril-associated bridges 0.009884567 14.5 NaN COL9A1;COL9A2
gefitinib Kinase inhibitor No MSN05 Down Collagen fibril organization by fibril-associated bridges 0.010986142 22.5 NaN COL9A1;COL9A2
gefitinib Kinase inhibitor No MSN06 Down Collagen fibril organization by fibril-associated bridges 0.011455252 17.5 NaN COL9A1;COL9A2
gefitinib Kinase inhibitor No MSN08 Down Collagen fibril organization by fibril-associated bridges 0.011320302 17.5 NaN COL9A1;COL9A2
gefitinib Kinase inhibitor No MSN09 Down Collagen fibril organization by fibril-associated bridges 0.010656589 20.5 NaN COL9A1;COL9A2
gefitinib Kinase inhibitor No MSN01 Down Contractile ring constriction 0.000179921 5.5 NaN ANLN;ECT2;MYLK
gefitinib Kinase inhibitor No MSN05 Down Contractile ring constriction 0.000211674 5.5 NaN ANLN;ECT2;MYLK
gefitinib Kinase inhibitor No MSN06 Down Contractile ring constriction 0.000225749 5.5 NaN ANLN;ECT2;MYLK
gefitinib Kinase inhibitor No MSN08 Down Contractile ring constriction 0.007691516 15.5 NaN ANLN;MYLK
gefitinib Kinase inhibitor No MSN09 Down Contractile ring constriction 0.000201982 6.5 NaN ANLN;ECT2;MYLK
gefitinib Kinase inhibitor No MSN05 Up Decorin synthesis 0.018613267 8.5 NaN DCN
gefitinib Kinase inhibitor No MSN06 Up Decorin synthesis 0.01711362 7 NaN DCN
gefitinib Kinase inhibitor No MSN08 Up Decorin synthesis 0.017554693 6 NaN DCN
gefitinib Kinase inhibitor No MSN09 Up Decorin synthesis 0.018525053 7 NaN DCN
gefitinib Kinase inhibitor No MSN01 Down Desaturation of fatty acids 0.013596343 16.5 NaN FADS2;SCD
gefitinib Kinase inhibitor No MSN05 Down Desaturation of fatty acids 0.015096478 26 NaN FADS2;SCD
gefitinib Kinase inhibitor No MSN06 Down Desaturation of fatty acids 0.015734625 20 NaN FADS2;SCD
gefitinib Kinase inhibitor No MSN08 Down Desaturation of fatty acids 0.015551089 19.5 NaN FADS2;SCD
gefitinib Kinase inhibitor No MSN09 Down Desaturation of fatty acids 0.014647932 23 NaN FADS2;SCD
gefitinib Kinase inhibitor No MSN01 Down DNA replication initiation 0.000444888 8 NaN CDC45;CDC6;GINS2;MCM10;MCM5
gefitinib Kinase inhibitor No MSN05 Down DNA replication initiation 0.000571445 9 NaN CDC45;CDC6;GINS2;MCM10;MCM5
gefitinib Kinase inhibitor No MSN09 Down DNA replication initiation 0.000531713 9 NaN CDC45;CDC6;GINS2;MCM10;MCM5
gefitinib Kinase inhibitor No MSN05 Down Epithelial intermediate filament dynamics 0.01975769 27.5 NaN KRT19;KRT7
gefitinib Kinase inhibitor No MSN06 Down Epithelial intermediate filament dynamics 0.020584442 21.5 NaN KRT19;KRT7
gefitinib Kinase inhibitor No MSN08 Down Epithelial intermediate filament dynamics 0.020346716 21.5 NaN KRT19;KRT7
gefitinib Kinase inhibitor No MSN09 Down Epithelial intermediate filament dynamics 0.019176257 24.5 NaN KRT19;KRT7
gefitinib Kinase inhibitor No MSN01 Down Equatorial RhoA activation 0.004096343 11 NaN ECT2;KIF23
gefitinib Kinase inhibitor No MSN05 Down Equatorial RhoA activation 0.00456203 17.5 NaN ECT2;KIF23
gefitinib Kinase inhibitor No MSN06 Down Equatorial RhoA activation 0.004760776 15.5 NaN ECT2;KIF23
gefitinib Kinase inhibitor No MSN09 Down Equatorial RhoA activation 0.004422563 16 NaN ECT2;KIF23
flecainide Antiarrhythmic Yes MSN05 Down Adrenergic receptor signaling 0.037291758 20 NaN RAPGEF4;RGS16;RGS4
flecainide Antiarrhythmic Yes MSN05 Down Aggrecan synthesis 0.028669725 13 NaN ACAN
flecainide Antiarrhythmic Yes MSN06 Down Aggrecan synthesis 0.027964008 18.5 NaN ACAN
flecainide Antiarrhythmic Yes MSN09 Down Aggrecan synthesis 0.028669725 16 NaN ACAN
flecainide Antiarrhythmic Yes MSN01 Up Albumin mediated blood protein transport 0.024788285 15 NaN ALB
flecainide Antiarrhythmic Yes MSN09 Down Albumin mediated blood protein transport 0.028669725 16 NaN ALB
flecainide Antiarrhythmic Yes MSN05 Up Alternative complement pathway 0.002298245 3 NaN C3;CFH
flecainide Antiarrhythmic Yes MSN06 Up Alternative complement pathway 0.002787899 3 NaN C3;CFH
flecainide Antiarrhythmic Yes MSN08 Up Alternative complement pathway 0.002990614 6.5 NaN C3;CFH
flecainide Antiarrhythmic Yes MSN09 Up Alternative complement pathway 0.00237668 5.5 NaN C3;CFH
flecainide Antiarrhythmic Yes MSN05 Down Antigen presentation via MHC class I molecules 0.031671949 17.5 NaN HLA-B;HLA-C
flecainide Antiarrhythmic Yes MSN06 Down Antigen presentation via MHC class I molecules 0.002245939 7 NaN HLA-A;HLA-B;HLA-C
flecainide Antiarrhythmic Yes MSN09 Down Antigen presentation via MHC class I molecules 0.031671949 21.5 NaN HLA-B;HLA-C
flecainide Antiarrhythmic Yes MSN05 Down Aspartate and arginine metabolism 0.031671949 17.5 NaN ARG2;SLC7A1
flecainide Antiarrhythmic Yes MSN06 Down Aspartate and arginine metabolism 0.030243397 20.5 NaN ARG2;SLC7A1
flecainide Antiarrhythmic Yes MSN08 Down Aspartate and arginine metabolism 0.029364515 18 NaN ARG2;SLC7A1
flecainide Antiarrhythmic Yes MSN09 Down Aspartate and arginine metabolism 0.031671949 21.5 NaN ARG2;SLC7A1
flecainide Antiarrhythmic Yes MSN09 Down Basement membrane assembly and organization 0.031671949 21.5 NaN COL4A4;HSPG2
flecainide Antiarrhythmic Yes MSN05 Up Biglycan synthesis 0.015437544 8 NaN BGN
flecainide Antiarrhythmic Yes MSN08 Up Biglycan synthesis 0.017642908 14 NaN BGN
flecainide Antiarrhythmic Yes MSN01 Down Biglycan synthesis 0.020289344 9 NaN BGN
flecainide Antiarrhythmic Yes MSN01 Up Cardiomyocyte depolarization during action potential 0.024788285 15 NaN SCN5A
flecainide Antiarrhythmic Yes MSN01 Up CD44-Mediated leukocyte rolling 0.048964244 19 NaN CD44
flecainide Antiarrhythmic Yes MSN06 Up Cellular cholesterol uptake and efflux 0.019882363 10.5 NaN ABCA1;ABCG1
flecainide Antiarrhythmic Yes MSN05 Up Cellular iron storage 0.045605319 13.5 NaN FTH1
flecainide Antiarrhythmic Yes MSN09 Up Cellular iron storage 0.046374785 20 NaN FTH1
flecainide Antiarrhythmic Yes MSN08 Up Centrosome maturation 0.018196826 17 NaN PLK1;TPX2
flecainide Antiarrhythmic Yes MSN08 Up Centrosome separation 1.82E-05 3 NaN CCNB1;CDK1;KIF11;NEK2
flecainide Antiarrhythmic Yes MSN09 Up Centrosome separation 0.010156124 10.5 NaN CDK1;KIF11
flecainide Antiarrhythmic Yes MSN06 Down Cholesterol synthesis 0.002039177 6 NaN DHCR24;DHCR7;FDFT1;MSMO1
flecainide Antiarrhythmic Yes MSN08 Down Cholesterol synthesis 7.77E-13 1 NaN CYP51A1;DHCR24;DHCR7;FDFT1;FDPS;HMGCR;HMGCS1;LSS;MSMO1;MVD;SQLE
flecainide Antiarrhythmic Yes MSN09 Down Class switch recombination 0.01609249 12 NaN BCL6;IL7R;IRF4
flecainide Antiarrhythmic Yes MSN06 Up Collagen fibril organization by fibril-associated bridges 0.004135058 5 NaN COL14A1;COL9A1
flecainide Antiarrhythmic Yes MSN08 Up Collagen fibril organization by fibril-associated bridges 0.004433898 9 NaN COL14A1;COL9A1
flecainide Antiarrhythmic Yes MSN05 Down Collagen fibril organization by fibril-associated bridges 0.011387686 8.5 NaN COL12A1;COL9A2
flecainide Antiarrhythmic Yes MSN08 Down Collagen fibril organization by fibril-associated bridges 0.010526062 10.5 NaN COL12A1;COL9A2
flecainide Antiarrhythmic Yes MSN05 Down Connection of muscle sarcomere to plasma membrane 0.031671949 17.5 NaN ANK3;TLN2
flecainide Antiarrhythmic Yes MSN09 Up Contractile ring constriction 0.00237668 5.5 NaN MYH14;MYLK
flecainide Antiarrhythmic Yes MSN05 Up Decorin synthesis 0.015437544 8 NaN DCN
flecainide Antiarrhythmic Yes MSN06 Up Decorin synthesis 0.017025406 8.5 NaN DCN
flecainide Antiarrhythmic Yes MSN08 Up Decorin synthesis 0.017642908 14 NaN DCN
flecainide Antiarrhythmic Yes MSN09 Up Decorin synthesis 0.015702188 12.5 NaN DCN
flecainide Antiarrhythmic Yes MSN08 Up Endogenous control of complement activity 0.002990614 6.5 NaN CFH;CFI
flecainide Antiarrhythmic Yes MSN01 Up Epithelial intermediate filament dynamics 0.0155326 9.5 NaN KRT19;KRT7
flecainide Antiarrhythmic Yes MSN05 Down ER unfolded protein response pathway 0.001174661 2 NaN ATF4;HERPUD1;PPP1R15A
flecainide Antiarrhythmic Yes MSN06 Down ER unfolded protein response pathway 0.019524203 14 NaN ATF4;HERPUD1
flecainide Antiarrhythmic Yes MSN08 Down ER unfolded protein response pathway 0.01894582 14 NaN ATF4;HERPUD1
flecainide Antiarrhythmic Yes MSN09 Down ER unfolded protein response pathway 0.001174661 3 NaN ATF4;HERPUD1;PPP1R15A
flecainide Antiarrhythmic Yes MSN06 Up Eukaryotic kinetochore dynamics 0.003823979 4 NaN CENPE;CENPF;CENPU;TTK
flecainide Antiarrhythmic Yes MSN08 Up Eukaryotic kinetochore dynamics 1.45E-08 1 NaN BUB1;CENPE;CENPF;MAD2L1;NDC80;NUF2;SPC24;TTK;ZWINT
flecainide Antiarrhythmic Yes MSN09 Up Eukaryotic kinetochore dynamics 1.75E-06 1 NaN BUB1;CENPF;CENPU;MAD2L1;NDC80;NUF2;TTK
flecainide Antiarrhythmic Yes MSN01 Up Extracellular matrix breakdown and membrane shedding by adamalysins 0.002654739 2 NaN ADAMTS1;ADAMTS14;ADAMTS15;ADAMTS6
flecainide Antiarrhythmic Yes MSN01 Down Extracellular matrix breakdown and membrane shedding by adamalysins 0.012182779 5 NaN ADAM33;ADAMTS2;ADAMTS5
flecainide Antiarrhythmic Yes MSN05 Down Extracellular matrix breakdown and membrane shedding by adamalysins 0.030266806 15 NaN ADAMTS1;ADAMTS12;ADAMTS14
flecainide Antiarrhythmic Yes MSN06 Down Extracellular matrix breakdown and membrane shedding by adamalysins 0.000454539 4 NaN ADAM19;ADAMTS1;ADAMTS12;ADAMTS14;ADAMTS4
flecainide Antiarrhythmic Yes MSN08 Down Extracellular matrix breakdown and membrane shedding by adamalysins 0.003869591 6 NaN ADAM19;ADAMTS1;ADAMTS12;ADAMTS14
flecainide Antiarrhythmic Yes MSN09 Down Extracellular matrix breakdown and membrane shedding by adamalysins 0.030266806 19 NaN ADAMTS1;ADAMTS12;ADAMTS14
flecainide Antiarrhythmic Yes MSN01 Down Extracellular matrix breakdown by heparanases and sulfatases 0.002393952 3 NaN SULF1;SULF2
flecainide Antiarrhythmic Yes MSN01 Up Extracellular matrix breakdown by matrix metalloproteases 0.019646762 11 NaN MMP12;MMP3
flecainide Antiarrhythmic Yes MSN05 Up Extracellular matrix breakdown by matrix metalloproteases 0.007943821 5 NaN MMP1;MMP2
flecainide Antiarrhythmic Yes MSN06 Up Extracellular matrix breakdown by matrix metalloproteases 0.009595627 7 NaN MMP1;MMP2
flecainide Antiarrhythmic Yes MSN09 Up Extracellular matrix breakdown by matrix metalloproteases 0.000298278 3 NaN MMP1;MMP14;MMP2
flecainide Antiarrhythmic Yes MSN01 Down Extracellular matrix breakdown by matrix metalloproteases 0.013432039 6 NaN MMP14;MMP2
flecainide Antiarrhythmic Yes MSN05 Down Extracellular matrix breakdown by matrix metalloproteases 0.02581992 11 NaN MMP12;MMP3
flecainide Antiarrhythmic Yes MSN06 Down Extracellular matrix breakdown by matrix metalloproteases 0.024643906 16.5 NaN MMP12;MMP3
flecainide Antiarrhythmic Yes MSN08 Down Extracellular matrix breakdown by matrix metalloproteases 0.023920818 16 NaN MMP12;MMP3
flecainide Antiarrhythmic Yes MSN09 Down Extracellular matrix breakdown by matrix metalloproteases 0.02581992 13 NaN MMP12;MMP3
flecainide Antiarrhythmic Yes MSN01 Up Fibrillar collagen core structure organization 0.02416119 12.5 NaN COL5A1;COL5A2
flecainide Antiarrhythmic Yes MSN05 Up Fibrillar collagen core structure organization 0.000400702 1 NaN COL1A1;COL2A1;COL3A1
flecainide Antiarrhythmic Yes MSN08 Up Fibrillar collagen core structure organization 0.01269743 12 NaN COL1A1;COL3A1
flecainide Antiarrhythmic Yes MSN09 Up Fibrillar collagen core structure organization 0.010156124 10.5 NaN COL1A1;COL3A1
flecainide Antiarrhythmic Yes MSN01 Down Fibrillar collagen core structure organization 0.016567476 7 NaN COL1A1;COL2A1
flecainide Antiarrhythmic Yes MSN05 Down Fibrillar collagen core structure organization 0.031671949 17.5 NaN COL11A1;COL5A1
flecainide Antiarrhythmic Yes MSN06 Down Fibrillar collagen core structure organization 0.030243397 20.5 NaN COL11A1;COL1A2
flecainide Antiarrhythmic Yes MSN09 Down Fibrillar collagen core structure organization 0.031671949 21.5 NaN COL11A1;COL5A1
flecainide Antiarrhythmic Yes MSN09 Down Fibrillin synthesis 0.00241178 4 NaN FBN2;FBN3
flecainide Antiarrhythmic Yes MSN09 Up Folate cycle 0.046374785 20 NaN DHFR
flecainide Antiarrhythmic Yes MSN08 Up G2 M transition checkpoint 0.018196826 17 NaN CCNB1;CDK1
flecainide Antiarrhythmic Yes MSN01 Up GABA metabolism 0.008598393 4.5 NaN ABAT;SLC6A1
flecainide Antiarrhythmic Yes MSN01 Down Glutamate and glutamine metabolism 0.027593758 11 NaN SLC1A5;SLC7A5
flecainide Antiarrhythmic Yes MSN05 Down Glycolysis and Gluconeogenesis 2.46E-06 1 NaN ENO1;HK2;LDHA;PCK2;PFKFB3;PFKFB4;PFKP
flecainide Antiarrhythmic Yes MSN06 Down Glycolysis and Gluconeogenesis 0.000368197 3 NaN HK2;LDHA;PCK2;PFKFB3;PFKFB4
flecainide Antiarrhythmic Yes MSN08 Down Glycolysis and Gluconeogenesis 2.82E-05 2 NaN ENO1;HK2;LDHA;PCK2;PFKFB3;PFKFB4
flecainide Antiarrhythmic Yes MSN09 Down Glycolysis and Gluconeogenesis 0.00041294 2 NaN HK2;LDHA;PCK2;PFKFB3;PFKFB4
flecainide Antiarrhythmic Yes MSN05 Up Granulocyte macrophage colony-stimulating factor receptor signaling 0.030638111 11 NaN JUND
flecainide Antiarrhythmic Yes MSN06 Up Granulocyte macrophage colony-stimulating factor receptor signaling 0.033762424 13.5 NaN JUND
flecainide Antiarrhythmic Yes MSN01 Down Granulocyte macrophage colony-stimulating factor receptor signaling 0.040168784 12 NaN JAK2
flecainide Antiarrhythmic Yes MSN06 Down Granulocyte-colony stimulating factor receptor signaling 0.024643906 16.5 NaN SOCS3;STAT3
flecainide Antiarrhythmic Yes MSN05 Up Hedgehog receptor signaling 0.034114417 12 NaN GAS1;MYCN
flecainide Antiarrhythmic Yes MSN09 Up Hedgehog receptor signaling 0.035192892 18 NaN GAS1;MYCN
flecainide Antiarrhythmic Yes MSN06 Up Hepatocyte growth factor receptor signaling 0.033762424 13.5 NaN HGF
flecainide Antiarrhythmic Yes MSN08 Up Hepatocyte growth factor receptor signaling 0.034976072 20 NaN HGF
flecainide Antiarrhythmic Yes MSN09 Up Hepatocyte growth factor receptor signaling 0.03115918 16.5 NaN HGF
flecainide Antiarrhythmic Yes MSN06 Down Inhibin receptor signaling 0.019524203 14 NaN INHBA;INHBE
flecainide Antiarrhythmic Yes MSN08 Down Inhibin receptor signaling 0.01894582 14 NaN INHBE;TGFBR3
flecainide Antiarrhythmic Yes MSN08 Up Inhibition of apoptosis 0.018196826 17 NaN BIRC5;XAF1
flecainide Antiarrhythmic Yes MSN01 Up Integrin-mediated leukocyte rolling 0.011841806 7 NaN SELPLG;VCAM1
flecainide Antiarrhythmic Yes MSN06 Down Integrin-mediated leukocyte rolling 0.01491633 12 NaN ICAM1;VCAM1
flecainide Antiarrhythmic Yes MSN09 Down Integrin-mediated leukocyte rolling 0.015642737 11 NaN ICAM1;VCAM1
flecainide Antiarrhythmic Yes MSN01 Up Interferon alpha receptor signaling 0.0155326 9.5 NaN IRF9;STAT1
flecainide Antiarrhythmic Yes MSN05 Down Interferon alpha receptor signaling 0.020465429 10 NaN IRF9;STAT1
flecainide Antiarrhythmic Yes MSN06 Down Interferon alpha receptor signaling 0.019524203 14 NaN IRF9;STAT1
flecainide Antiarrhythmic Yes MSN08 Down Interferon alpha receptor signaling 0.01894582 14 NaN IRF9;STAT1
flecainide Antiarrhythmic Yes MSN01 Up Interferon beta receptor signaling 0.011841806 7 NaN IFIT2;IRF9
flecainide Antiarrhythmic Yes MSN08 Down Interferon beta receptor signaling 0.014470218 12 NaN IFIT2;IRF9
flecainide Antiarrhythmic Yes MSN01 Up JAK-STAT signaling pathway 0.04578962 17.5 NaN SOCS2;STAT1
flecainide Antiarrhythmic Yes MSN05 Down JAK-STAT signaling pathway 0.006718883 6 NaN SOCS2;SOCS3;STAT1
flecainide Antiarrhythmic Yes MSN06 Down JAK-STAT signaling pathway 0.000481016 5 NaN SOCS3;STAT1;STAT3;USP18
flecainide Antiarrhythmic Yes MSN08 Down JAK-STAT signaling pathway 0.000452858 4 NaN SOCS2;SOCS3;STAT1;USP18
flecainide Antiarrhythmic Yes MSN09 Down JAK-STAT signaling pathway 0.006718883 8 NaN SOCS2;STAT1;USP18
flecainide Antiarrhythmic Yes MSN06 Down Leptin receptor signaling 0.004505994 8 NaN SOCS3;STAT3
flecainide Antiarrhythmic Yes MSN08 Down Lipogenesis 0.000755151 5 NaN ACLY;FASN
flecainide Antiarrhythmic Yes MSN08 Up Metaphase to anaphase checkpoint 2.49E-05 4 NaN BUB1;CCNB2;CENPE;MAD2L1;PTTG1;TTK
flecainide Antiarrhythmic Yes MSN09 Up Metaphase to anaphase checkpoint 0.015941817 14 NaN BUB1;MAD2L1;TTK
flecainide Antiarrhythmic Yes MSN08 Up Microtubule destabilization 0.004433898 9 NaN KIF2C;STMN1
flecainide Antiarrhythmic Yes MSN06 Up Mitotic spindle assembly 5.16E-05 1 NaN CKAP2;DLGAP5;TACC3;TTK
flecainide Antiarrhythmic Yes MSN08 Up Mitotic spindle assembly 1.87E-06 2 NaN CKAP2;DLGAP5;NUSAP1;TPX2;TTK
flecainide Antiarrhythmic Yes MSN09 Up Mitotic spindle assembly 3.76E-05 2 NaN CKAP2;DLGAP5;NUSAP1;TTK
flecainide Antiarrhythmic Yes MSN05 Up Mitotic spindle disassembly 0.015437544 8 NaN CDK1
flecainide Antiarrhythmic Yes MSN08 Up Mitotic spindle disassembly 0.017642908 14 NaN CDK1
flecainide Antiarrhythmic Yes MSN09 Up Mitotic spindle disassembly 0.015702188 12.5 NaN CDK1
flecainide Antiarrhythmic Yes MSN01 Up Myofibril formation 0.02416119 12.5 NaN KLHL41;XIRP1
flecainide Antiarrhythmic Yes MSN05 Down Natriuretic peptide receptor signaling 0.011387686 8.5 NaN NPPA;NPPB
flecainide Antiarrhythmic Yes MSN06 Down Natriuretic peptide receptor signaling 0.010853767 10.5 NaN NPPA;NPPB
flecainide Antiarrhythmic Yes MSN08 Down Natriuretic peptide receptor signaling 0.010526062 10.5 NaN NPPA;NPPB
flecainide Antiarrhythmic Yes MSN09 Down Natriuretic peptide receptor signaling 0.011387686 9.5 NaN NPPA;NPPB
flecainide Antiarrhythmic Yes MSN01 Up Nodal growth differentiation factor receptor signaling 0.04578962 17.5 NaN LEFTY2;TCEA3
flecainide Antiarrhythmic Yes MSN09 Up Nuclear envelope maintenance 0.003528251 7.5 NaN LMNB1;TMPO
flecainide Antiarrhythmic Yes MSN09 Up Nuclear intermediate filaments 0.003528251 7.5 NaN LMNB1;TMPO
flecainide Antiarrhythmic Yes MSN06 Down Oncostatin-M receptor signaling 0.007371482 9 NaN OSMR;STAT3
flecainide Antiarrhythmic Yes MSN05 Up Osteonectin receptor signaling 0.001393088 2 NaN SMOC2;SPARC
flecainide Antiarrhythmic Yes MSN06 Up Osteonectin receptor signaling 0.001691693 2 NaN SMOC2;SPARC
flecainide Antiarrhythmic Yes MSN08 Up Osteonectin receptor signaling 0.001815452 5 NaN SMOC2;SPARC
flecainide Antiarrhythmic Yes MSN09 Up Osteonectin receptor signaling 0.001440887 4 NaN SMOC2;SPARC
flecainide Antiarrhythmic Yes MSN01 Up Osteopontin receptor signaling 0.024788285 15 NaN SPP1
flecainide Antiarrhythmic Yes MSN05 Down Osteopontin receptor signaling 0.028669725 13 NaN SPP1
flecainide Antiarrhythmic Yes MSN08 Down Osteopontin receptor signaling 0.027522936 17 NaN SPP1
flecainide Antiarrhythmic Yes MSN09 Down Osteopontin receptor signaling 0.028669725 16 NaN SPP1
flecainide Antiarrhythmic Yes MSN09 Down Perlecan synthesis 0.028669725 16 NaN HSPG2
flecainide Antiarrhythmic Yes MSN01 Down Platelet-derived growth factor receptor signaling 4.87E-05 1.5 NaN PDGFD;PDGFRA;PDGFRB;RGS5
flecainide Antiarrhythmic Yes MSN06 Down Platelet-derived growth factor receptor signaling 0.036292017 22 NaN FOSL1;PDGFRB
flecainide Antiarrhythmic Yes MSN01 Up Polyol pathway 5.92E-05 1 NaN AKR1A1;AKR1B10;SORD
flecainide Antiarrhythmic Yes MSN01 Down Progesterone receptor signaling 0.020289344 9 NaN PGR
flecainide Antiarrhythmic Yes MSN01 Up Prolactin receptor signaling 0.005827311 3 NaN PRLR;SOCS2
flecainide Antiarrhythmic Yes MSN05 Down Prolactin receptor signaling 0.007737756 7 NaN PRLR;SOCS2
flecainide Antiarrhythmic Yes MSN05 Up Pyrimidine synthesis and salvage 0.006241574 4 NaN TK1;TYMS
flecainide Antiarrhythmic Yes MSN06 Up Pyrimidine synthesis and salvage 0.007547364 6 NaN TK1;TYMS
flecainide Antiarrhythmic Yes MSN08 Up Pyrimidine synthesis and salvage 0.00808616 11 NaN TK1;TYMS
flecainide Antiarrhythmic Yes MSN09 Up Pyrimidine synthesis and salvage 0.00645117 9 NaN TK1;TYMS
flecainide Antiarrhythmic Yes MSN08 Up Removal of caspase inhibition 0.034976072 20 NaN XAF1
flecainide Antiarrhythmic Yes MSN05 Up Retinol metabolism 0.016528769 10 NaN ALDH1A2;RDH10
flecainide Antiarrhythmic Yes MSN06 Up Retinol metabolism 0.019882363 10.5 NaN ALDH1A2;RDH10
flecainide Antiarrhythmic Yes MSN05 Down Retinol metabolism 0.005392406 5 NaN ALDH1A1;ALDH1A3;TTR
flecainide Antiarrhythmic Yes MSN06 Down Retinol metabolism 0.000351283 2 NaN ALDH1A1;DHRS3;STRA6;TTR
flecainide Antiarrhythmic Yes MSN08 Down Retinol metabolism 0.04822006 19 NaN ALDH1A1;ALDH1A3
flecainide Antiarrhythmic Yes MSN09 Down Retinol metabolism 0.000386293 1 NaN ALDH1A1;DHRS3;STRA6;TTR
flecainide Antiarrhythmic Yes MSN05 Up Ribonucleotide reduction 0.045605319 13.5 NaN RRM2
flecainide Antiarrhythmic Yes MSN09 Up Ribonucleotide reduction 0.046374785 20 NaN RRM2
flecainide Antiarrhythmic Yes MSN01 Up Selectin-mediated Leukocyte rolling 0.008598393 4.5 NaN SELPLG;VCAM1
flecainide Antiarrhythmic Yes MSN06 Down Selectin-mediated Leukocyte rolling 0.010853767 10.5 NaN ICAM1;VCAM1
flecainide Antiarrhythmic Yes MSN09 Down Selectin-mediated Leukocyte rolling 0.011387686 9.5 NaN ICAM1;VCAM1
flecainide Antiarrhythmic Yes MSN01 Down Serine and glycine metabolism 4.87E-05 1.5 NaN PHGDH;PSAT1;SHMT2;SLC1A5
flecainide Antiarrhythmic Yes MSN05 Down Serine and glycine metabolism 0.003246259 3 NaN PHGDH;PSAT1;SHMT2
flecainide Antiarrhythmic Yes MSN06 Down Serine and glycine metabolism 0.00016949 1 NaN PHGDH;PSAT1;SHMT2;SLC1A5
flecainide Antiarrhythmic Yes MSN08 Down Serine and glycine metabolism 0.000159398 3 NaN PHGDH;PSAT1;SHMT2;SLC1A5
flecainide Antiarrhythmic Yes MSN09 Down Serine and glycine metabolism 0.003246259 5 NaN PHGDH;PSAT1;SHMT2
flecainide Antiarrhythmic Yes MSN06 Up Sister chromatid attachment to mitotic spindle 0.033762424 13.5 NaN TACC3
flecainide Antiarrhythmic Yes MSN08 Up Sister chromatid attachment to mitotic spindle 0.034976072 20 NaN NUF2
flecainide Antiarrhythmic Yes MSN09 Up Sister chromatid attachment to mitotic spindle 0.03115918 16.5 NaN NUF2
flecainide Antiarrhythmic Yes MSN08 Up Sister chromatid segregation 0.004433898 9 NaN PTTG1;TOP2A
flecainide Antiarrhythmic Yes MSN08 Down Tenascin receptor signaling 0.004367359 8 NaN TENM1;TNC
flecainide Antiarrhythmic Yes MSN09 Down Tenascin receptor signaling 0.004732134 6.5 NaN TENM1;TNC
flecainide Antiarrhythmic Yes MSN08 Down Thrombospondin receptor signaling 0.004367359 8 NaN THBS1;THBS2
flecainide Antiarrhythmic Yes MSN05 Up Tight junction organization 0.015237229 6 NaN CLDN11;CRB2;EMP1
flecainide Antiarrhythmic Yes MSN05 Down Transmembrane glucose transport 0.004732134 4 NaN SLC2A1;SLC2A3
flecainide Antiarrhythmic Yes MSN08 Down Transmembrane glucose transport 0.004367359 8 NaN SLC2A1;SLC2A3
flecainide Antiarrhythmic Yes MSN09 Down Transmembrane glucose transport 0.004732134 6.5 NaN SLC2A1;SLC2A3
flecainide Antiarrhythmic Yes MSN01 Down Tropoelastin synthesis 0.020289344 9 NaN ELN
flecainide Antiarrhythmic Yes MSN05 Down Tropoelastin synthesis 0.028669725 13 NaN ELN
flecainide Antiarrhythmic Yes MSN06 Down Tropoelastin synthesis 0.027964008 18.5 NaN ELN
flecainide Antiarrhythmic Yes MSN09 Down Tropoelastin synthesis 0.028669725 16 NaN ELN
flecainide Antiarrhythmic Yes MSN01 Up Vascular endothelial growth factor receptor signaling 0.011841806 7 NaN FLT1;KDR
flecainide Antiarrhythmic Yes MSN06 Up Versican receptor signaling 0.033762424 13.5 NaN VCAN
flecainide Antiarrhythmic Yes MSN06 Up Versican synthesis 0.017025406 8.5 NaN VCAN
flecainide Antiarrhythmic Yes MSN09 Up WNT-Beta-catenin signaling pathway 0.017982282 15 NaN FRZB;FZD7;SFRP4;WNT1
flecainide Antiarrhythmic Yes MSN01 Down WNT-Beta-catenin signaling pathway 0.009503625 4 NaN FZD10;FZD7;MSX2;SFRP5;WNT1
estradiol Female sex hormone No MSN01 Down Natriuretic peptide receptor signaling 0.000130795 2 NaN NPPA;NPPB;NPR1
estradiol Female sex hormone No MSN05 Down Natriuretic peptide receptor signaling 0.000100982 3 NaN NPPA;NPPB;NPR1
estradiol Female sex hormone No MSN08 Down Natriuretic peptide receptor signaling 0.000165872 2 NaN NPPA;NPPB;NPR1
estradiol Female sex hormone No MSN09 Down Natriuretic peptide receptor signaling 0.004787543 6 NaN NPPA;NPPB
estradiol Female sex hormone No MSN05 Down Notch receptor signaling 0.046930028 21.5 NaN DLK1;NOTCH3
estradiol Female sex hormone No MSN01 Up Osteonectin receptor signaling 0.003705518 4.5 NaN SMOC2;SPOCK1
estradiol Female sex hormone No MSN05 Up Osteonectin receptor signaling 7.86E-05 1 NaN SMOC2;SPARC;SPOCK1
estradiol Female sex hormone No MSN08 Up Osteonectin receptor signaling 0.003072996 5 NaN SMOC2;SPOCK1
estradiol Female sex hormone No MSN01 Up Osteopontin receptor signaling 0.025317572 11.5 NaN SPP1
estradiol Female sex hormone No MSN05 Up Osteopontin receptor signaling 0.027258292 13.5 NaN SPP1
estradiol Female sex hormone No MSN06 Up Osteopontin receptor signaling 0.025494001 14 NaN SPP1
estradiol Female sex hormone No MSN08 Up Osteopontin receptor signaling 0.023023994 12 NaN SPP1
estradiol Female sex hormone No MSN09 Up Osteopontin receptor signaling 0.025052929 8.5 NaN SPP1
estradiol Female sex hormone No MSN01 Up Platelet-derived growth factor receptor signaling 0.002278637 3 NaN PDGFRA;PDGFRB;RGS5
estradiol Female sex hormone No MSN05 Up Platelet-derived growth factor receptor signaling 0.002812672 6 NaN PDGFRA;PDGFRB;RGS5
estradiol Female sex hormone No MSN08 Up Platelet-derived growth factor receptor signaling 0.025324824 14 NaN PDGFRA;RGS5
estradiol Female sex hormone No MSN05 Up Progesterone receptor signaling 0.027258292 13.5 NaN PGR
estradiol Female sex hormone No MSN08 Up Progesterone receptor signaling 0.023023994 12 NaN PGR
estradiol Female sex hormone No MSN06 Down Prostacycline receptor signaling 0.037920328 16.5 NaN PTGIR
estradiol Female sex hormone No MSN01 Up Prostaglandin E2 receptor signaling 0.008957388 8.5 NaN PTGER3;RAPGEF4
estradiol Female sex hormone No MSN05 Up Prostaglandin E2 receptor signaling 0.010331661 9.5 NaN PTGER3;RAPGEF4
estradiol Female sex hormone No MSN08 Up Prostaglandin E2 receptor signaling 0.007451277 6.5 NaN PTGER3;RAPGEF4
estradiol Female sex hormone No MSN01 Up Prostaglandin PGF2 alpha receptor signaling 0.049996342 17.5 NaN PTGFR
estradiol Female sex hormone No MSN08 Up Prostaglandin PGF2 alpha receptor signaling 0.045519869 16.5 NaN PTGFR
estradiol Female sex hormone No MSN08 Down Protein polyubiquitination 0.042096917 21 NaN ISG15;UCHL1
estradiol Female sex hormone No MSN01 Up Removal of caspase inhibition 0.049996342 17.5 NaN XAF1
estradiol Female sex hormone No MSN09 Up Removal of caspase inhibition 0.049480363 14.5 NaN XAF1
estradiol Female sex hormone No MSN06 Down Removal of caspase inhibition 0.037920328 16.5 NaN XAF1
estradiol Female sex hormone No MSN06 Up Restriction point 0.025462828 11 NaN CDKN2A;PFKFB3
estradiol Female sex hormone No MSN01 Down Restriction point 0.01470451 11 NaN CCND2;PFKFB3
estradiol Female sex hormone No MSN06 Down Restriction point 0.014834304 5.5 NaN CCND2;CDKN1A
estradiol Female sex hormone No MSN09 Down Restriction point 0.01368451 11 NaN CCND1;CCND2
estradiol Female sex hormone No MSN01 Up Retinol metabolism 0.041452288 14 NaN ALDH1A1;RPE65
estradiol Female sex hormone No MSN05 Up Retinol metabolism 0.047387116 16.5 NaN ALDH1A1;RPE65
estradiol Female sex hormone No MSN06 Up Retinol metabolism 0.00387928 4 NaN ALDH1A1;RPE65;STRA6
estradiol Female sex hormone No MSN08 Up Retinol metabolism 0.002908016 4 NaN ALDH1A1;RDH10;RPE65
estradiol Female sex hormone No MSN09 Up Retinol metabolism 0.04066719 11.5 NaN ALDH1A1;RLBP1
estradiol Female sex hormone No MSN01 Down Retinol metabolism 0.024550455 16.5 NaN ALDH1A2;DHRS3
estradiol Female sex hormone No MSN05 Down Retinol metabolism 0.001319125 6 NaN ALDH1A2;ALDH1A3;DHRS3
estradiol Female sex hormone No MSN06 Down Retinol metabolism 0.02476286 11 NaN ALDH1A3;DHRS3
estradiol Female sex hormone No MSN08 Down Retinol metabolism 0.028490468 17.5 NaN ALDH1A2;DHRS3
estradiol Female sex hormone No MSN09 Down Retinol metabolism 0.02287923 15 NaN ALDH1A2;DHRS3
estradiol Female sex hormone No MSN08 Up Roundabout signaling 0.01027406 8.5 NaN ROBO1;ROBO2
estradiol Female sex hormone No MSN01 Down Selectin-mediated Leukocyte rolling 0.005154036 7.5 NaN ICAM1;VCAM1
estradiol Female sex hormone No MSN05 Down Selectin-mediated Leukocyte rolling 0.004347503 10 NaN ICAM1;VCAM1
estradiol Female sex hormone No MSN08 Down Selectin-mediated Leukocyte rolling 0.006025215 7 NaN ICAM1;VCAM1
estradiol Female sex hormone No MSN09 Down Selectin-mediated Leukocyte rolling 0.004787543 6 NaN ICAM1;VCAM1
estradiol Female sex hormone No MSN05 Down Serine and glycine metabolism 0.015050282 13 NaN PHGDH;PSAT1
estradiol Female sex hormone No MSN06 Down Serine and glycine metabolism 0.017904373 7 NaN PHGDH;SLC1A5
estradiol Female sex hormone No MSN08 Down Serine and glycine metabolism 0.001267475 4 NaN PHGDH;PSAT1;SHMT2
estradiol Female sex hormone No MSN09 Down Serine and glycine metabolism 0.000901167 3 NaN PHGDH;PSAT1;SHMT2
estradiol Female sex hormone No MSN01 Up Serotonin inactivation 0.049996342 17.5 NaN MAOA
estradiol Female sex hormone No MSN06 Up Serotonin inactivation 0.000647752 1 NaN MAOA;MAOB
estradiol Female sex hormone No MSN08 Up Serotonin inactivation 0.045519869 16.5 NaN MAOA
estradiol Female sex hormone No MSN05 Down Serotonin inactivation 0.000303564 4 NaN MAOA;MAOB
estradiol Female sex hormone No MSN01 Down Sister chromatid attachment to mitotic spindle 0.037747261 20 NaN TACC3
estradiol Female sex hormone No MSN08 Down Sister chromatid attachment to mitotic spindle 0.040860087 19.5 NaN TACC3
estradiol Female sex hormone No MSN01 Down Sister chromatid segregation 0.005154036 7.5 NaN PTTG1;TOP2A
estradiol Female sex hormone No MSN01 Up Tenascin receptor signaling 0.003705518 4.5 NaN TENM1;TNC
estradiol Female sex hormone No MSN05 Down Thin myofilament organization 0.006016727 11.5 NaN ACTA1;TNNI3
estradiol Female sex hormone No MSN08 Down Thin myofilament organization 0.008320961 8.5 NaN ACTA1;TNNI3
estradiol Female sex hormone No MSN05 Up Thrombospondin receptor signaling 0.004285177 7 NaN THBS2;THBS4
estradiol Female sex hormone No MSN09 Up Thrombospondin receptor signaling 6.11E-05 2 NaN THBS1;THBS2;THBS4
estradiol Female sex hormone No MSN01 Down Tropoelastin synthesis 0.01905434 14 NaN ELN
estradiol Female sex hormone No MSN05 Down Tropoelastin synthesis 0.017466478 15 NaN ELN
estradiol Female sex hormone No MSN06 Down Tropoelastin synthesis 0.019142555 9 NaN ELN
estradiol Female sex hormone No MSN08 Down Tropoelastin synthesis 0.020642202 13.5 NaN ELN
estradiol Female sex hormone No MSN09 Down Tropoelastin synthesis 0.018348624 13.5 NaN ELN
estradiol Female sex hormone No MSN09 Down Urea cycle 0.004787543 6 NaN ARG2;ASS1
estradiol Female sex hormone No MSN01 Up Vascular endothelial growth factor receptor signaling 0.012331868 10 NaN FLT1;KDR
estradiol Female sex hormone No MSN01 Down Vasoactive intestinal peptide receptor signaling 0.037747261 20 NaN VIPR2
estradiol Female sex hormone No MSN06 Down Versican receptor signaling 0.037920328 16.5 NaN VCAN
estradiol Female sex hormone No MSN09 Down Versican receptor signaling 0.036362165 17 NaN VCAN
estradiol Female sex hormone No MSN06 Down Versican synthesis 0.019142555 9 NaN VCAN
estradiol Female sex hormone No MSN09 Down Versican synthesis 0.018348624 13.5 NaN VCAN
estradiol Female sex hormone No MSN01 Up WNT-Beta-catenin signaling pathway 0.005475082 6 NaN APCDD1;DKK2;FRZB;PAX6;SFRP2;WNT9A
estradiol Female sex hormone No MSN05 Up WNT-Beta-catenin signaling pathway 0.007777734 8 NaN APCDD1;DKK2;FRZB;PAX6;SFRP2;WNT9A
estradiol Female sex hormone No MSN09 Up WNT-Beta-catenin signaling pathway 0.02184092 7 NaN APCDD1;DACT1;DKK2;FRZB;WNT2
estradiol Female sex hormone No MSN06 Down WNT-Beta-catenin signaling pathway 0.001365143 2 NaN CXXC5;FRAT1;FRZB;FZD8;SFRP2;WNT9A
estradiol Female sex hormone No MSN05 Up Extracellular matrix breakdown and membrane shedding by adamalysins 0.026579947 12 NaN ADAM12;ADAM33;ADAMTS14
estradiol Female sex hormone No MSN06 Up Extracellular matrix breakdown and membrane shedding by adamalysins 0.002938485 2.5 NaN ADAM33;ADAMTS13;ADAMTS2;ADAMTS5
estradiol Female sex hormone No MSN08 Up Extracellular matrix breakdown and membrane shedding by adamalysins 0.002029311 2 NaN ADAM15;ADAM33;ADAMTS14;ADAMTS5
estradiol Female sex hormone No MSN06 Up Extracellular matrix breakdown by cathepsins 0.025462828 11 NaN CTSF;CTSV
estradiol Female sex hormone No MSN01 Down Extracellular matrix breakdown by cathepsins 0.01470451 11 NaN CTSF;CTSL
estradiol Female sex hormone No MSN08 Down Extracellular matrix breakdown by cathepsins 0.017117729 11 NaN CTSL;CTSV
estradiol Female sex hormone No MSN05 Up Extracellular matrix breakdown by matrix metalloproteases 0.023491402 11 NaN MMP1;MMP2
estradiol Female sex hormone No MSN09 Down Extracellular matrix breakdown by matrix metalloproteases 0.011080479 9 NaN MMP1;MMP14
estradiol Female sex hormone No MSN06 Up Fibrillar collagen core structure organization 0.025462828 11 NaN COL1A1;COL2A1
estradiol Female sex hormone No MSN08 Up Fibrillar collagen core structure organization 0.021035933 10 NaN COL11A1;COL5A1
estradiol Female sex hormone No MSN01 Down Fibrillar collagen core structure organization 0.000741619 4 NaN COL1A1;COL2A1;COL5A2
estradiol Female sex hormone No MSN05 Down Fibrillar collagen core structure organization 0.000575325 5 NaN COL1A2;COL2A1;COL3A1
estradiol Female sex hormone No MSN06 Down Fibrillar collagen core structure organization 0.014834304 5.5 NaN COL1A2;COL3A1
estradiol Female sex hormone No MSN08 Down Fibrillar collagen core structure organization 3.37E-05 1 NaN COL1A1;COL1A2;COL2A1;COL3A1
estradiol Female sex hormone No MSN09 Down Fibrillar collagen core structure organization 2.12E-05 1 NaN COL1A2;COL2A1;COL3A1;COL5A2
estradiol Female sex hormone No MSN01 Up Fibroblast growth factor receptor signaling 0.035660258 13 NaN FGF18;FGFR3
estradiol Female sex hormone No MSN05 Up Fibroblast growth factor receptor signaling 0.000225406 3 NaN FGF1;FGF10;FGF18;FGFR3
estradiol Female sex hormone No MSN08 Up Fibroblast growth factor receptor signaling 0.002275399 3 NaN FGF10;FGF18;FGFR3
estradiol Female sex hormone No MSN08 Up Fibulin receptor signaling 0.045519869 16.5 NaN FBLN1
estradiol Female sex hormone No MSN06 Up Filopodium organization 0.002938485 2.5 NaN GAP43;MYO3A;RHOU;TXNRD1
estradiol Female sex hormone No MSN06 Down Glutamate and glutamine metabolism 0.001716959 3 NaN SLC1A5;SLC38A2;SLC7A5
estradiol Female sex hormone No MSN06 Up Glycolysis and Gluconeogenesis 0.019913353 8 NaN LDHA;PCK2;PFKFB3
estradiol Female sex hormone No MSN05 Down G-protein coupled receptor signaling pathway 0.046930028 21.5 NaN GRK5;RGS4
estradiol Female sex hormone No MSN01 Up Granulocyte macrophage colony-stimulating factor receptor signaling 0.049996342 17.5 NaN JAK2
estradiol Female sex hormone No MSN09 Up Granulocyte macrophage colony-stimulating factor receptor signaling 0.049480363 14.5 NaN JAK2
estradiol Female sex hormone No MSN05 Down Granulocyte macrophage colony-stimulating factor receptor signaling 0.034629393 18.5 NaN JUND
estradiol Female sex hormone No MSN09 Up Granulocyte-colony stimulating factor receptor signaling 0.020044392 5.5 NaN SOCS3;STAT3
estradiol Female sex hormone No MSN06 Down Hepatocyte growth factor receptor signaling 0.037920328 16.5 NaN HGF
estradiol Female sex hormone No MSN06 Down Inhibin receptor signaling 0.009465755 4 NaN INHBB;TGFBR3
estradiol Female sex hormone No MSN01 Up Inhibition of amyloid aggregation, amyloid degradation and uptake 0.001884281 2 NaN MME;PLAT
estradiol Female sex hormone No MSN08 Up Inhibition of amyloid aggregation, amyloid degradation and uptake 1.21E-05 1 NaN A2M;MME;PLAT
estradiol Female sex hormone No MSN09 Up Inhibition of amyloid aggregation, amyloid degradation and uptake 1.56E-05 1 NaN A2M;MME;PLAT
estradiol Female sex hormone No MSN06 Down Inhibition of amyloid aggregation, amyloid degradation and uptake 0.001080503 1 NaN MME;PLAT
estradiol Female sex hormone No MSN09 Up Inhibition of apoptosis 0.034978854 10 NaN BIRC5;XAF1
estradiol Female sex hormone No MSN01 Up Inositol metabolism and transport 0.049996342 17.5 NaN SLC5A3
estradiol Female sex hormone No MSN01 Down Integrin-mediated leukocyte rolling 0.007125381 9 NaN ICAM1;VCAM1
estradiol Female sex hormone No MSN05 Down Integrin-mediated leukocyte rolling 0.006016727 11.5 NaN ICAM1;VCAM1
estradiol Female sex hormone No MSN08 Down Integrin-mediated leukocyte rolling 0.008320961 8.5 NaN ICAM1;VCAM1
estradiol Female sex hormone No MSN09 Down Integrin-mediated leukocyte rolling 0.006621825 8 NaN ICAM1;VCAM1
estradiol Female sex hormone No MSN09 Up JAK-STAT signaling pathway 0.046676079 13 NaN SOCS3;STAT3
estradiol Female sex hormone No MSN06 Down JAK-STAT signaling pathway 0.028530911 12.5 NaN SOCS2;SOCS3
estradiol Female sex hormone No MSN09 Up Leptin receptor signaling 0.003629621 3 NaN SOCS3;STAT3
estradiol Female sex hormone No MSN01 Down Lipogenesis 0.037747261 20 NaN FASN
estradiol Female sex hormone No MSN06 Up Macrophage migration inhibitory factor signaling 0.006155642 5.5 NaN CXCR4;JUND
estradiol Female sex hormone No MSN08 Down MAPK signaling pathway 0.023390507 16 NaN DUSP1;FOXM1;MAP2K6
estradiol Female sex hormone No MSN05 Down Methionine cycle 0.034629393 18.5 NaN BHMT
estradiol Female sex hormone No MSN06 Down Methionine cycle 0.037920328 16.5 NaN BHMT
estradiol Female sex hormone No MSN08 Down Methionine cycle 0.040860087 19.5 NaN BHMT
estradiol Female sex hormone No MSN01 Up Microfibril scaffold organization 0.049996342 17.5 NaN FBN1
estradiol Female sex hormone No MSN08 Up Microfibril scaffold organization 0.045519869 16.5 NaN FBN1
estradiol Female sex hormone No MSN06 Down Microfibril scaffold organization 0.037920328 16.5 NaN FBN1
estradiol Female sex hormone No MSN01 Down Mitotic spindle assembly 0.024550455 16.5 NaN TACC3;TPX2
estradiol Female sex hormone No MSN08 Down Mitotic spindle assembly 0.028490468 17.5 NaN TACC3;TPX2
estradiol Female sex hormone No MSN08 Down Adherens junction organization 0.00985309 10 NaN CDH1;CDH3;CDH5;PLEKHA7
estradiol Female sex hormone No MSN01 Down Aggrecan synthesis 0.01905434 14 NaN ACAN
estradiol Female sex hormone No MSN01 Up Albumin mediated blood protein transport 0.025317572 11.5 NaN ALB
estradiol Female sex hormone No MSN08 Up Albumin mediated blood protein transport 0.023023994 12 NaN ALB
estradiol Female sex hormone No MSN06 Up Alternative complement pathway 0.006155642 5.5 NaN C3;CFH
estradiol Female sex hormone No MSN01 Down Alternative complement pathway 0.003479622 5.5 NaN C3;CFH
estradiol Female sex hormone No MSN05 Down Alternative complement pathway 0.002931996 8 NaN C3;CFH
estradiol Female sex hormone No MSN08 Down Alternative complement pathway 0.004072101 5.5 NaN C3;CFH
estradiol Female sex hormone No MSN09 Up Androgen synthesis 0.020044392 5.5 NaN HSD17B2;SRD5A2
estradiol Female sex hormone No MSN06 Up Antigen presentation via MHC class I molecules 0.025462828 11 NaN B2M;HLA-B
estradiol Female sex hormone No MSN01 Down Antigen presentation via MHC class I molecules 0.01470451 11 NaN B2M;HLA-B
estradiol Female sex hormone No MSN09 Down Aspartate and arginine metabolism 0.01368451 11 NaN ARG2;ASS1
estradiol Female sex hormone No MSN01 Up Axonal intermediate filament dynamics 0.00052119 1 NaN NEFH;NEFM;NES
estradiol Female sex hormone No MSN05 Up Axonal intermediate filament dynamics 0.000647115 5 NaN NEFH;NEFL;NEFM
estradiol Female sex hormone No MSN08 Up Axonal intermediate filament dynamics 0.01027406 8.5 NaN NEFH;NEFM
estradiol Female sex hormone No MSN05 Up Basement membrane assembly and organization 0.028842387 15 NaN COL4A4;COL8A2
estradiol Female sex hormone No MSN09 Down Basement membrane assembly and organization 0.01368451 11 NaN COL4A4;COL4A5
estradiol Female sex hormone No MSN09 Down Bicarbonate transmembrane transport 0.04668964 18 NaN CA9;SLC4A5
estradiol Female sex hormone No MSN09 Up Biglycan synthesis 0.025052929 8.5 NaN BGN
estradiol Female sex hormone No MSN05 Down Biglycan synthesis 0.017466478 15 NaN BGN
estradiol Female sex hormone No MSN08 Down Biglycan synthesis 0.020642202 13.5 NaN BGN
estradiol Female sex hormone No MSN08 Down Cardiomyocyte depolarization during action potential 0.020642202 13.5 NaN SCN5A
estradiol Female sex hormone No MSN06 Down Cardiomyocyte repolarization during action potential and hyperpolarization 0.028530911 12.5 NaN KCNA1;KCNJ2
estradiol Female sex hormone No MSN01 Down CCN intercellular signaling protein family receptor signaling 0.003479622 5.5 NaN CTGF;CYR61
estradiol Female sex hormone No MSN05 Down CCN intercellular signaling protein family receptor signaling 0.002931996 8 NaN CTGF;CYR61
estradiol Female sex hormone No MSN08 Down CCN intercellular signaling protein family receptor signaling 0.004072101 5.5 NaN CTGF;CYR61
estradiol Female sex hormone No MSN09 Up Cellular cholesterol uptake and efflux 0.04066719 11.5 NaN ABCA1;ABCG1
estradiol Female sex hormone No MSN06 Up Centrosome separation 0.025462828 11 NaN AURKA;CCNB1
estradiol Female sex hormone No MSN05 Up Chloride transmembrane transport 0.047387116 16.5 NaN BEST1;SLC12A7
estradiol Female sex hormone No MSN01 Down Cholesterol synthesis 2.94E-05 1 NaN CYP27A1;DHCR24;DHCR7;FDFT1;SQLE
estradiol Female sex hormone No MSN05 Down Cholesterol synthesis 2.85E-08 1 NaN DHCR24;DHCR7;FDFT1;FDPS;HMGCS1;MVD;SQLE
estradiol Female sex hormone No MSN06 Up Cholesterol transport by lipoproteins 0.016384625 7 NaN APOD;APOE
estradiol Female sex hormone No MSN09 Up Classical complement pathway 0.012085707 4 NaN C1QB;C1QC
estradiol Female sex hormone No MSN05 Down Collagen fiber crosslinking 0.002931996 8 NaN LOXL1;PXDN
estradiol Female sex hormone No MSN09 Down Collagen fiber crosslinking 0.003230669 4 NaN LOXL1;PXDN
estradiol Female sex hormone No MSN01 Up Collagen fibril organization by fibril-associated bridges 0.008957388 8.5 NaN COL9A2;COL9A3
estradiol Female sex hormone No MSN05 Up Collagen fibril organization by fibril-associated bridges 0.000377393 4 NaN COL12A1;COL9A2;COL9A3
estradiol Female sex hormone No MSN08 Up Collagen fibril organization by fibril-associated bridges 0.007451277 6.5 NaN COL12A1;COL9A2
estradiol Female sex hormone No MSN09 Down Collagen fibril organization by fibril-associated bridges 0.000116919 2 NaN COL12A1;COL14A1;COL9A1
estradiol Female sex hormone No MSN05 Up Connection of muscle sarcomere to extracellular matrix 0.010331661 9.5 NaN AGRN;SGCD
estradiol Female sex hormone No MSN01 Up Contractile ring constriction 0.006072761 7 NaN MYH14;MYLK
estradiol Female sex hormone No MSN05 Up Contractile ring constriction 0.000192586 2 NaN ANLN;MYH14;MYLK
estradiol Female sex hormone No MSN01 Down Decorin synthesis 0.01905434 14 NaN DCN
estradiol Female sex hormone No MSN05 Down Decorin synthesis 0.017466478 15 NaN DCN
estradiol Female sex hormone No MSN06 Down Decorin synthesis 0.019142555 9 NaN DCN
estradiol Female sex hormone No MSN08 Down Decorin synthesis 0.020642202 13.5 NaN DCN
estradiol Female sex hormone No MSN05 Down Drug and toxin export via membrane transport proteins 0.038656545 20 NaN ABCC3;ABCG2
estradiol Female sex hormone No MSN06 Down Drug and toxin export via membrane transport proteins 0.045637959 20 NaN ABCC4;ABCG2
estradiol Female sex hormone No MSN01 Down Epithelial intermediate filament dynamics 0.000356006 3 NaN KRT4;KRT7;TCHH
estradiol Female sex hormone No MSN05 Down Epithelial intermediate filament dynamics 5.98E-06 2 NaN KRT19;KRT4;KRT7;TCHH
estradiol Female sex hormone No MSN01 Down Z-disc organization 0.036387431 18 NaN DES;PDLIM3
estradiol Female sex hormone No MSN05 Down Z-disc organization 0.031015341 17 NaN LDB3;PDLIM3
estradiol Female sex hormone No MSN08 Down Z-disc organization 0.000264919 3 NaN DES;LDB3;MYPN;PDLIM3
estradiol Female sex hormone No MSN09 Down Z-disc organization 0.033957087 16 NaN DES;MYPN
erlotinib Kinase inhibitor No MSN01 Down Eukaryotic kinetochore dynamics 4.34E-11 1 NaN BUB1;CENPE;CENPF;CENPH;CENPI;CENPU;MAD2L1;NDC80;NUF2;SKA3;SPC24;TTK;ZWINT
erlotinib Kinase inhibitor No MSN05 Down Eukaryotic kinetochore dynamics 5.98E-06 4 NaN BUB1;CENPE;CENPF;CENPU;NDC80;NUF2;SPC24;TTK;ZWINT
erlotinib Kinase inhibitor No MSN08 Down Eukaryotic kinetochore dynamics 1.36E-09 3 NaN BUB1;CENPE;CENPF;CENPI;CENPU;MAD2L1;NDC80;NUF2;SKA3;SPC24;TTK;ZWINT
erlotinib Kinase inhibitor No MSN09 Down Eukaryotic kinetochore dynamics 2.09E-13 2 NaN BUB1;CENPE;CENPF;CENPH;CENPI;CENPU;CENPW;KIF15;MAD2L1;NDC80;NUF2;SKA3;SPC24;TTK;ZWINT
erlotinib Kinase inhibitor No MSN01 Up Extracellular matrix breakdown and membrane shedding by adamalysins 0.005062955 6 NaN ADAMTS1;ADAMTS2;ADAMTS5
erlotinib Kinase inhibitor No MSN08 Up Extracellular matrix breakdown and membrane shedding by adamalysins 0.03825978 8.5 NaN ADAM33;ADAMTS5
erlotinib Kinase inhibitor No MSN01 Up Extracellular matrix breakdown by matrix metalloproteases 0.000247135 4 NaN MMP14;MMP2;MMP3
erlotinib Kinase inhibitor No MSN01 Down Fanconi anemia interstrand cross-link repair pathway 0.000106227 7 NaN BRCA2;BRIP1;FANCA;FANCD2;FANCI;UBE2T
erlotinib Kinase inhibitor No MSN05 Down Fanconi anemia interstrand cross-link repair pathway 0.002073589 13 NaN BRIP1;FANCA;FANCD2;FANCI;UBE2T
erlotinib Kinase inhibitor No MSN08 Down Fanconi anemia interstrand cross-link repair pathway 0.000144661 8 NaN BRCA2;BRIP1;FANCA;FANCD2;FANCI;UBE2T
erlotinib Kinase inhibitor No MSN09 Down Fanconi anemia interstrand cross-link repair pathway 1.22E-05 6 NaN BRCA2;BRIP1;FANCA;FANCD2;FANCG;FANCI;UBE2T
erlotinib Kinase inhibitor No MSN08 Up Fibrillar collagen core structure organization 0.007020173 3 NaN COL1A2;COL3A1
erlotinib Kinase inhibitor No MSN05 Down Fibrillar collagen core structure organization 0.000292192 8 NaN COL11A1;COL1A2;COL2A1;COL3A1
erlotinib Kinase inhibitor No MSN08 Down G2 M transition checkpoint 0.005910219 19.5 NaN CCNB1;CDC25C;CDK1
erlotinib Kinase inhibitor No MSN09 Down G2 M transition checkpoint 0.005687739 19.5 NaN CCNB1;CDC25C;CDK1
erlotinib Kinase inhibitor No MSN01 Up Glutamate and glutamine metabolism 0.015125858 9 NaN SLC1A5;SLC7A5
erlotinib Kinase inhibitor No MSN09 Up Glutamate and glutamine metabolism 0.013943597 5 NaN SLC1A5;SLC7A5
erlotinib Kinase inhibitor No MSN08 Up Glycogen synthesis and glycogenolysis 0.017792498 6 NaN PPP1R3A;PYGM
erlotinib Kinase inhibitor No MSN08 Down Glycolysis and Gluconeogenesis 0.005818361 18 NaN ENO1;LDHA;PFKFB3;PFKFB4
erlotinib Kinase inhibitor No MSN09 Down Glycolysis and Gluconeogenesis 0.000667411 13 NaN ENO1;LDHA;PFKFB4;PGK1;TPI1
erlotinib Kinase inhibitor No MSN09 Up Granulocyte macrophage colony-stimulating factor receptor signaling 0.028030666 10.5 NaN JAK2
erlotinib Kinase inhibitor No MSN01 Up Heme degradation to bilirubin 0.043551386 14.5 NaN HMOX1
erlotinib Kinase inhibitor No MSN05 Up Heme degradation to bilirubin 0.0298696 8 NaN HMOX1
erlotinib Kinase inhibitor No MSN08 Up Heme degradation to bilirubin 0.038403665 10.5 NaN HMOX1
erlotinib Kinase inhibitor No MSN09 Up Heme degradation to bilirubin 0.041751778 16 NaN HMOX1
erlotinib Kinase inhibitor No MSN01 Up Heparin-binding EGF-like growth factor receptor signaling 0.043551386 14.5 NaN HBEGF
erlotinib Kinase inhibitor No MSN09 Up Heparin-binding EGF-like growth factor receptor signaling 0.041751778 16 NaN HBEGF
erlotinib Kinase inhibitor No MSN01 Down Homologous recombination DSB repair 0.002587189 15 NaN BRCA2;EXO1;PIF1;RAD51AP1;RMI2;XRCC2
erlotinib Kinase inhibitor No MSN08 Down Homologous recombination DSB repair 0.00062358 14 NaN BRCA2;EXO1;PIF1;RAD51AP1;RECQL4;RMI2;XRCC2
erlotinib Kinase inhibitor No MSN09 Down Homologous recombination DSB repair 0.000574555 11 NaN BRCA2;EXO1;PIF1;RAD51AP1;RECQL4;RMI2;XRCC2
erlotinib Kinase inhibitor No MSN01 Up Hyaluronan receptor CD44 signaling 0.043551386 14.5 NaN CD44
erlotinib Kinase inhibitor No MSN09 Up Hyaluronan receptor CD44 signaling 0.041751778 16 NaN CD44
erlotinib Kinase inhibitor No MSN05 Down Inhibition of amyloid aggregation, amyloid degradation and uptake 0.003784402 14.5 NaN A2M;PLAT
erlotinib Kinase inhibitor No MSN01 Down Inhibition of apoptosis 0.005051379 18.5 NaN BIRC5;IFI6;XAF1
erlotinib Kinase inhibitor No MSN01 Down Intracellular bridge assembly 0.002730596 16 NaN INCENP;KIF23
erlotinib Kinase inhibitor No MSN08 Down Intracellular bridge assembly 0.00305221 16.5 NaN INCENP;KIF23
erlotinib Kinase inhibitor No MSN09 Down Intracellular bridge assembly 0.002970165 17 NaN INCENP;KIF23
erlotinib Kinase inhibitor No MSN08 Up Intrinsic apoptosis pathway 0.013722762 5 NaN BMF;PMAIP1
erlotinib Kinase inhibitor No MSN01 Up Lipogenesis 0.029247909 11 NaN FASN
erlotinib Kinase inhibitor No MSN05 Up Macrophage migration inhibitory factor signaling 0.049289604 12 NaN ACKR3
erlotinib Kinase inhibitor No MSN09 Up Mammalian target of rapamycin signaling pathway 0.023432976 8 NaN DDIT4;EIF4EBP1
erlotinib Kinase inhibitor No MSN01 Down Metaphase to anaphase checkpoint 6.30E-06 5 NaN BUB1;BUB1B;CCNB2;CDC20;CENPE;MAD2L1;PTTG1;TTK
erlotinib Kinase inhibitor No MSN05 Down Metaphase to anaphase checkpoint 0.000172103 7 NaN BUB1;BUB1B;CCNB2;CDC20;CENPE;PTTG1;TTK
erlotinib Kinase inhibitor No MSN08 Down Metaphase to anaphase checkpoint 8.87E-07 5 NaN BUB1;BUB1B;CCNB2;CDC20;CENPE;MAD2L1;PLK3;PTTG1;TTK
erlotinib Kinase inhibitor No MSN09 Down Metaphase to anaphase checkpoint 7.90E-07 5 NaN BUB1;BUB1B;CCNB2;CDC20;CENPE;MAD2L1;PLK3;PTTG1;TTK
erlotinib Kinase inhibitor No MSN01 Down Microtubule destabilization 0.012844883 23 NaN KIF2C;STMN2
erlotinib Kinase inhibitor No MSN05 Down Microtubule destabilization 0.017606258 25 NaN KIF2C;STMN1
erlotinib Kinase inhibitor No MSN08 Down Microtubule destabilization 0.000620884 12.5 NaN KIF2C;STMN1;STMN2
erlotinib Kinase inhibitor No MSN09 Down Microtubule destabilization 0.013934524 26.5 NaN KIF2C;STMN1
erlotinib Kinase inhibitor No MSN01 Down Mitotic chromosome condensation 0.017622656 26 NaN INCENP;SMC4
erlotinib Kinase inhibitor No MSN08 Down Mitotic chromosome condensation 0.019605117 29.5 NaN INCENP;SMC4
erlotinib Kinase inhibitor No MSN09 Down Mitotic chromosome condensation 0.001018951 15 NaN INCENP;NCAPG2;SMC4
erlotinib Kinase inhibitor No MSN01 Down Mitotic H3 phosphorylation and dephosphorylation 0.000269315 8.5 NaN AURKB;CCNA2;INCENP
erlotinib Kinase inhibitor No MSN05 Down Mitotic H3 phosphorylation and dephosphorylation 0.012022011 21.5 NaN AURKB;CCNA2
erlotinib Kinase inhibitor No MSN08 Down Mitotic H3 phosphorylation and dephosphorylation 0.000318058 10.5 NaN AURKB;CCNA2;INCENP
erlotinib Kinase inhibitor No MSN09 Down Mitotic H3 phosphorylation and dephosphorylation 0.000305372 9.5 NaN AURKB;CCNA2;INCENP
erlotinib Kinase inhibitor No MSN01 Down Mitotic spindle assembly 2.71E-05 6 NaN DLGAP5;NUSAP1;TACC3;TPX2;TTK
erlotinib Kinase inhibitor No MSN05 Down Mitotic spindle assembly 5.97E-05 5 NaN DLGAP5;NUSAP1;TACC3;TPX2;TTK
erlotinib Kinase inhibitor No MSN08 Down Mitotic spindle assembly 3.55E-05 6 NaN DLGAP5;NUSAP1;TACC3;TPX2;TTK
erlotinib Kinase inhibitor No MSN09 Down Mitotic spindle assembly 3.32E-05 8 NaN DLGAP5;NUSAP1;TACC3;TPX2;TTK
erlotinib Kinase inhibitor No MSN01 Down Natriuretic peptide receptor signaling 0.00052644 10.5 NaN NPPA;NPPB;NPR3
erlotinib Kinase inhibitor No MSN05 Down Natriuretic peptide receptor signaling 0.017606258 25 NaN NPPA;NPPB
erlotinib Kinase inhibitor No MSN08 Down Natriuretic peptide receptor signaling 0.014306674 27 NaN NPPA;NPPB
erlotinib Kinase inhibitor No MSN09 Down Natriuretic peptide receptor signaling 0.013934524 26.5 NaN NPPA;NPPB
erlotinib Kinase inhibitor No MSN09 Up Neuregulin receptor signaling 0.010015357 4 NaN ERBB3;ERBB4
erlotinib Kinase inhibitor No MSN01 Down Notch receptor signaling 0.021860488 28 NaN DLK1;JAG1;LFNG
erlotinib Kinase inhibitor No MSN05 Down Notch receptor signaling 0.033481638 30 NaN DLK1;JAG1;NOTCH1
erlotinib Kinase inhibitor No MSN01 Down Nuclear intermediate filaments 0.012844883 23 NaN LMNB1;LMNB2
erlotinib Kinase inhibitor No MSN08 Down Nuclear intermediate filaments 0.014306674 27 NaN LMNB1;LMNB2
erlotinib Kinase inhibitor No MSN09 Down Nuclear intermediate filaments 0.013934524 26.5 NaN LMNB1;LMNB2
erlotinib Kinase inhibitor No MSN09 Down Nucleosome assembly 0.004694952 18 NaN ASF1B;CHAF1A;CHAF1B;HIST1H1C
erlotinib Kinase inhibitor No MSN05 Down Platelet-derived growth factor receptor signaling 0.000446155 10 NaN PDGFB;PDGFRA;PDGFRB;TNK2
erlotinib Kinase inhibitor No MSN01 Up Potassium transmembrane transport 0.04817565 17 NaN ABCC9;ATP1A3
erlotinib Kinase inhibitor No MSN08 Up Potassium transmembrane transport 0.03825978 8.5 NaN ABCC9;ATP1A3
erlotinib Kinase inhibitor No MSN05 Up Proline metabolism 0.049289604 12 NaN PYCR1
erlotinib Kinase inhibitor No MSN05 Up Protein polyubiquitination 0.010972286 4 NaN UBC;UCHL1
erlotinib Kinase inhibitor No MSN09 Up Protein polyubiquitination 0.020867035 7 NaN ISG15;UCHL1
erlotinib Kinase inhibitor No MSN01 Down Pyrimidine synthesis and salvage 0.02302747 29 NaN TK1;TYMS
erlotinib Kinase inhibitor No MSN05 Down Pyrimidine synthesis and salvage 0.031334889 29 NaN TK1;TYMS
erlotinib Kinase inhibitor No MSN05 Down Retinol metabolism 0.010112539 19 NaN ALDH1A1;ALDH1A3;RBP1
erlotinib Kinase inhibitor No MSN09 Down Ribonucleotide reduction 3.20E-05 7 NaN RRM1;RRM2;RRM2B
erlotinib Kinase inhibitor No MSN01 Up Serine and glycine metabolism 1.38E-05 2 NaN PHGDH;PSAT1;SHMT2;SLC1A5
erlotinib Kinase inhibitor No MSN05 Up Serine and glycine metabolism 0.000154114 2 NaN PHGDH;PSAT1;SHMT2
erlotinib Kinase inhibitor No MSN08 Up Serine and glycine metabolism 0.00032663 2 NaN PHGDH;PSAT1;SHMT2
erlotinib Kinase inhibitor No MSN09 Up Serine and glycine metabolism 2.27E-07 1 NaN PHGDH;PSAT1;PSPH;SHMT2;SLC1A5
erlotinib Kinase inhibitor No MSN09 Up Serotonin inactivation 0.028030666 10.5 NaN MAOA
erlotinib Kinase inhibitor No MSN01 Down Sister chromatid attachment to mitotic spindle 0.000928996 13 NaN NUF2;TACC3
erlotinib Kinase inhibitor No MSN05 Down Sister chromatid attachment to mitotic spindle 0.001292329 12 NaN NUF2;TACC3
erlotinib Kinase inhibitor No MSN08 Down Sister chromatid attachment to mitotic spindle 0.001039663 15 NaN NUF2;TACC3
erlotinib Kinase inhibitor No MSN09 Down Sister chromatid attachment to mitotic spindle 0.001011413 14 NaN NUF2;TACC3
erlotinib Kinase inhibitor No MSN08 Down Sister chromatid cohesion 0.009104659 23 NaN CDCA5;CHTF18;ESCO2;WDHD1
erlotinib Kinase inhibitor No MSN09 Down Sister chromatid cohesion 0.008682532 22 NaN CDCA5;CHTF18;ESCO2;WDHD1
erlotinib Kinase inhibitor No MSN01 Down Sister chromatid segregation 0.00052644 10.5 NaN ESPL1;PTTG1;TOP2A
erlotinib Kinase inhibitor No MSN05 Down Sister chromatid segregation 0.000853518 11 NaN ESPL1;PTTG1;TOP2A
erlotinib Kinase inhibitor No MSN08 Down Sister chromatid segregation 0.000620884 12.5 NaN ESPL1;PTTG1;TOP2A
erlotinib Kinase inhibitor No MSN09 Down Sister chromatid segregation 0.00059632 12 NaN ESPL1;PTTG1;TOP2A
erlotinib Kinase inhibitor No MSN05 Down Telomere replication and maintenance 0.018281238 27 NaN EXO1;PIF1;RECQL4
erlotinib Kinase inhibitor No MSN08 Down Telomere replication and maintenance 0.013672665 25 NaN EXO1;PIF1;RECQL4
erlotinib Kinase inhibitor No MSN09 Down Telomere replication and maintenance 0.013175198 24 NaN EXO1;PIF1;RECQL4
erlotinib Kinase inhibitor No MSN01 Down Tenascin receptor signaling 0.005350967 20.5 NaN TENM1;TNC
erlotinib Kinase inhibitor No MSN08 Down Tenascin receptor signaling 0.00597407 21.5 NaN TENM1;TNC
erlotinib Kinase inhibitor No MSN01 Down Thin myofilament organization 0.000900451 12 NaN ACTA1;TPM2;TPM4
erlotinib Kinase inhibitor No MSN05 Down Thrombospondin receptor signaling 0.007388595 16.5 NaN THBS2;THBS4
erlotinib Kinase inhibitor No MSN01 Up Tropoelastin synthesis 0.014731828 8 NaN ELN
erlotinib Kinase inhibitor No MSN09 Up Tropoelastin synthesis 0.014114326 6 NaN ELN
erlotinib Kinase inhibitor No MSN01 Down Vascular endothelial growth factor receptor signaling 0.017622656 26 NaN FLT1;KDR
erlotinib Kinase inhibitor No MSN01 Up Vasoactive intestinal peptide receptor signaling 0.000215746 3 NaN VIPR1;VIPR2
erlotinib Kinase inhibitor No MSN05 Up Vasoactive intestinal peptide receptor signaling 0.020012661 5.5 NaN VIPR1
erlotinib Kinase inhibitor No MSN08 Up Vasoactive intestinal peptide receptor signaling 0.025768046 7 NaN VIPR1
erlotinib Kinase inhibitor No MSN09 Up Vasoactive intestinal peptide receptor signaling 0.028030666 10.5 NaN VIPR1
erlotinib Kinase inhibitor No MSN05 Up VDJ recombination 0.049289604 12 NaN PAX5
erlotinib Kinase inhibitor No MSN01 Up Androgen receptor signaling 0.029247909 11 NaN AR
erlotinib Kinase inhibitor No MSN05 Up Androgen receptor signaling 0.020012661 5.5 NaN AR
erlotinib Kinase inhibitor No MSN05 Down Apoptosome assembly 0.012022011 21.5 NaN CDC6;CYCS
erlotinib Kinase inhibitor No MSN01 Up Aspartate and arginine metabolism 0.008982766 7 NaN ARG2;SLC7A1
erlotinib Kinase inhibitor No MSN05 Up Aspartate and arginine metabolism 0.004279686 3 NaN ARG2;SLC7A1
erlotinib Kinase inhibitor No MSN09 Up Aspartate and arginine metabolism 0.00827056 3 NaN ARG2;SLC7A1
erlotinib Kinase inhibitor No MSN01 Down Axonal intermediate filament dynamics 0.017622656 26 NaN NEFL;NES
erlotinib Kinase inhibitor No MSN05 Down Axonal intermediate filament dynamics 0.024067226 28 NaN NEFL;NES
erlotinib Kinase inhibitor No MSN08 Down Axonal intermediate filament dynamics 0.019605117 29.5 NaN NEFL;NES
erlotinib Kinase inhibitor No MSN09 Down Axonal intermediate filament dynamics 0.019100753 29.5 NaN NEFL;NES
erlotinib Kinase inhibitor No MSN09 Down Base excision repair 0.011313575 23 NaN FEN1;NEIL3;PCNA;POLQ
erlotinib Kinase inhibitor No MSN05 Down CCN intercellular signaling protein family receptor signaling 0.012022011 21.5 NaN CTGF;CYR61
erlotinib Kinase inhibitor No MSN01 Up CD44-Mediated leukocyte rolling 0.029247909 11 NaN CD44
erlotinib Kinase inhibitor No MSN09 Up CD44-Mediated leukocyte rolling 0.028030666 10.5 NaN CD44
erlotinib Kinase inhibitor No MSN01 Up Cellular iron storage 0.043551386 14.5 NaN FTL
erlotinib Kinase inhibitor No MSN05 Up Cellular iron storage 0.0298696 8 NaN FTL
erlotinib Kinase inhibitor No MSN09 Up Cellular iron storage 0.041751778 16 NaN FTL
erlotinib Kinase inhibitor No MSN01 Down Centrosome maturation 0.005051379 18.5 NaN AURKA;PLK1;TPX2
erlotinib Kinase inhibitor No MSN05 Down Centrosome maturation 0.007989519 18 NaN AURKA;PLK1;TPX2
erlotinib Kinase inhibitor No MSN08 Down Centrosome maturation 0.005910219 19.5 NaN AURKA;PLK1;TPX2
erlotinib Kinase inhibitor No MSN09 Down Centrosome maturation 0.005687739 19.5 NaN AURKA;PLK1;TPX2
erlotinib Kinase inhibitor No MSN01 Down Centrosome organization 0.004556707 17 NaN ASPM;NEK2;PLK4;POC1A;STIL;TACC3;WDR62
erlotinib Kinase inhibitor No MSN08 Down Centrosome organization 0.000316324 9 NaN ASPM;NEK2;PAX6;PLK3;PLK4;POC1A;STIL;TACC3;WDR62
erlotinib Kinase inhibitor No MSN09 Down Centrosome organization 0.001365192 16 NaN ASPM;NEK2;PLK3;PLK4;POC1A;STIL;TACC3;WDR62
erlotinib Kinase inhibitor No MSN01 Down Centrosome separation 2.58E-09 3 NaN AURKA;CCNB1;CDK1;ESPL1;KIF11;NEK2;SPAG5
erlotinib Kinase inhibitor No MSN05 Down Centrosome separation 8.13E-09 2 NaN AURKA;CCNB1;CDK1;ESPL1;KIF11;NEK2;SPAG5
erlotinib Kinase inhibitor No MSN08 Down Centrosome separation 4.66E-11 2 NaN AURKA;CCNB1;CDK1;ESPL1;KIF11;NEK2;NEK6;SPAG5
erlotinib Kinase inhibitor No MSN09 Down Centrosome separation 3.47E-09 3 NaN AURKA;CCNB1;CDK1;ESPL1;KIF11;NEK2;SPAG5
erlotinib Kinase inhibitor No MSN01 Up Cholesterol synthesis 0.002977256 5 NaN DHCR7;HMGCR;HMGCS1
erlotinib Kinase inhibitor No MSN09 Up Class switch recombination 0.028927884 13 NaN BCL6;IL7R
erlotinib Kinase inhibitor No MSN05 Down Collagen fiber crosslinking 0.012022011 21.5 NaN LOX;LOXL1
erlotinib Kinase inhibitor No MSN08 Down Collagen fiber crosslinking 0.009744744 24 NaN LOX;LOXL1
erlotinib Kinase inhibitor No MSN01 Down Collagen fibril organization by fibril-associated bridges 0.012844883 23 NaN COL9A1;COL9A2
erlotinib Kinase inhibitor No MSN05 Down Collagen fibril organization by fibril-associated bridges 0.017606258 25 NaN COL9A1;COL9A2
erlotinib Kinase inhibitor No MSN08 Down Collagen fibril organization by fibril-associated bridges 0.014306674 27 NaN COL9A1;COL9A2
erlotinib Kinase inhibitor No MSN09 Down Collagen fibril organization by fibril-associated bridges 0.013934524 26.5 NaN COL9A1;COL9A2
erlotinib Kinase inhibitor No MSN05 Up Contractile ring constriction 0.049289604 12 NaN MYH14
erlotinib Kinase inhibitor No MSN01 Down Contractile ring constriction 0.000269315 8.5 NaN ANLN;ECT2;MYLK
erlotinib Kinase inhibitor No MSN05 Down Contractile ring constriction 0.000438469 9 NaN ANLN;ECT2;MYLK
erlotinib Kinase inhibitor No MSN08 Down Contractile ring constriction 0.000318058 10.5 NaN ANLN;ECT2;MYLK
erlotinib Kinase inhibitor No MSN09 Down Contractile ring constriction 0.000305372 9.5 NaN ANLN;ECT2;MYLK
erlotinib Kinase inhibitor No MSN05 Up Contractile ring formation 0.049289604 12 NaN MYH14
erlotinib Kinase inhibitor No MSN08 Up Decorin synthesis 0.012967537 4 NaN DCN
erlotinib Kinase inhibitor No MSN09 Down Desaturation of fatty acids 0.019100753 29.5 NaN FADS2;SCD
erlotinib Kinase inhibitor No MSN05 Up Discoidin domain receptor signaling 0.0298696 8 NaN DDR2
erlotinib Kinase inhibitor No MSN08 Up Discoidin domain receptor signaling 0.038403665 10.5 NaN DDR2
erlotinib Kinase inhibitor No MSN09 Up Discoidin domain receptor signaling 0.041751778 16 NaN DDR2
erlotinib Kinase inhibitor No MSN01 Down DNA replication elongation 2.58E-08 4 NaN MCM2;MCM4;MCM5;MCM7;PCNA
erlotinib Kinase inhibitor No MSN05 Down DNA replication elongation 5.90E-08 3 NaN MCM2;MCM4;MCM5;MCM7;PCNA
erlotinib Kinase inhibitor No MSN08 Down DNA replication elongation 3.42E-08 4 NaN MCM2;MCM4;MCM5;MCM7;PCNA
erlotinib Kinase inhibitor No MSN09 Down DNA replication elongation 3.19E-08 4 NaN MCM2;MCM4;MCM5;MCM7;PCNA
erlotinib Kinase inhibitor No MSN01 Down DNA replication initiation 5.56E-11 2 NaN CDC45;CDC6;GINS1;GINS2;MCM10;MCM2;MCM4;MCM5;MCM6;MCM7;ORC6
erlotinib Kinase inhibitor No MSN05 Down DNA replication initiation 1.37E-11 1 NaN CDC45;CDC6;GINS1;GINS2;GINS4;MCM10;MCM2;MCM4;MCM5;MCM6;MCM7;ORC6
erlotinib Kinase inhibitor No MSN08 Down DNA replication initiation 3.82E-12 1 NaN CDC45;CDC6;GINS1;GINS2;GINS4;MCM10;MCM2;MCM4;MCM5;MCM6;MCM7;ORC6
erlotinib Kinase inhibitor No MSN09 Down DNA replication initiation 2.79E-15 1 NaN CDC45;CDC6;GINS1;GINS2;GINS4;MCM10;MCM2;MCM3;MCM4;MCM5;MCM6;MCM7;ORC6;TICRR
erlotinib Kinase inhibitor No MSN05 Down Elastin cross-linking and assembly 0.003784402 14.5 NaN LOX;LOXL1
erlotinib Kinase inhibitor No MSN08 Down Elastin cross-linking and assembly 0.00305221 16.5 NaN LOX;LOXL1
erlotinib Kinase inhibitor No MSN01 Down Epithelial intermediate filament dynamics 0.001408213 14 NaN KRT19;KRT7;KRT8
erlotinib Kinase inhibitor No MSN05 Down Epithelial intermediate filament dynamics 0.000103168 6 NaN KRT19;KRT7;KRT8;TCHH
erlotinib Kinase inhibitor No MSN08 Down Epithelial intermediate filament dynamics 6.75E-05 7 NaN KRT19;KRT7;KRT8;TCHH
erlotinib Kinase inhibitor No MSN01 Down Equatorial RhoA activation 0.005350967 20.5 NaN ECT2;KIF23
erlotinib Kinase inhibitor No MSN05 Down Equatorial RhoA activation 0.007388595 16.5 NaN ECT2;KIF23
erlotinib Kinase inhibitor No MSN08 Down Equatorial RhoA activation 0.00597407 21.5 NaN ECT2;KIF23
erlotinib Kinase inhibitor No MSN09 Down Equatorial RhoA activation 0.005815223 21 NaN ECT2;KIF23
erlotinib Kinase inhibitor No MSN01 Up ER unfolded protein response pathway 3.04E-06 1 NaN ATF4;DDIT3;HERPUD1;PPP1R15A
erlotinib Kinase inhibitor No MSN05 Up ER unfolded protein response pathway 5.35E-05 1 NaN ATF4;DDIT3;HERPUD1
erlotinib Kinase inhibitor No MSN08 Up ER unfolded protein response pathway 1.83E-06 1 NaN ATF4;DDIT3;HERPUD1;PPP1R15A
erlotinib Kinase inhibitor No MSN09 Up ER unfolded protein response pathway 2.56E-06 2 NaN ATF4;DDIT3;HERPUD1;PPP1R15A
epirubicin Anthracycline Yes MSN01 Up Actin filament severing and depolymerization 0.001130494 7 NaN CFL1;CFL2;DSTN;GSN
epirubicin Anthracycline Yes MSN05 Up Actin filament severing and depolymerization 0.013122147 18.5 NaN CFL2;DSTN;GSN
epirubicin Anthracycline Yes MSN09 Up Actin filament severing and depolymerization 0.01562199 17 NaN CFL1;DSTN;GSN
epirubicin Anthracycline Yes MSN01 Up Actin polymerization 0.004845366 9 NaN BRK1;CTTN;EVL;HSPB1;PFN1;TMSB10
epirubicin Anthracycline Yes MSN06 Up Albumin mediated blood protein transport 0.033874382 14 NaN ALB
epirubicin Anthracycline Yes MSN09 Up Albumin mediated blood protein transport 0.042254764 26.5 NaN ALB
epirubicin Anthracycline Yes MSN01 Up Amination of alpha-keto acids and deamination of amino acids 0.008260669 11 NaN GLUD1;LOXL2
epirubicin Anthracycline Yes MSN05 Up Amination of alpha-keto acids and deamination of amino acids 0.00890615 13.5 NaN GLUD1;LOXL2
epirubicin Anthracycline Yes MSN09 Up Amination of alpha-keto acids and deamination of amino acids 0.010100879 14 NaN GLUD1;LOXL2
epirubicin Anthracycline Yes MSN01 Up Amyloid plaque organization 0.000554461 6 NaN APOE;APP;HSPB6;SNCA
epirubicin Anthracycline Yes MSN05 Up Amyloid plaque organization 0.000641825 5 NaN APOE;APP;HSPB6;SNCA
epirubicin Anthracycline Yes MSN06 Up Amyloid plaque organization 0.00035402 3 NaN APOE;APP;HSPB6;SNCA
epirubicin Anthracycline Yes MSN09 Up Amyloid plaque organization 0.000819486 5.5 NaN APP;HSPB6;SNCA;SOD1
epirubicin Anthracycline Yes MSN05 Up Antigen presentation via MHC class I molecules 0.000421575 3.5 NaN B2M;ERAP1;HLA-B;HLA-C
epirubicin Anthracycline Yes MSN06 Up Antigen presentation via MHC class I molecules 0.00387498 7 NaN B2M;HLA-B;HLA-C
epirubicin Anthracycline Yes MSN06 Down Apoptosome assembly 0.046744878 8.5 NaN BAG3
epirubicin Anthracycline Yes MSN01 Up Basement membrane assembly and organization 0.000363747 4.5 NaN COL4A1;ITGB1;LAMC1;NID1
epirubicin Anthracycline Yes MSN05 Up Basement membrane assembly and organization 0.000421575 3.5 NaN COL4A1;ITGB1;LAMC1;NID1
epirubicin Anthracycline Yes MSN01 Up Basement membrane attachment to cell surface 2.94E-05 2.5 NaN BCAM;BSG;CD151;NID1
epirubicin Anthracycline Yes MSN05 Up Basement membrane attachment to cell surface 3.42E-05 2 NaN BCAM;BSG;CD151;NID1
epirubicin Anthracycline Yes MSN06 Up Basement membrane attachment to cell surface 1.84E-05 2 NaN BCAM;BSG;CD151;NID1
epirubicin Anthracycline Yes MSN09 Up Basement membrane attachment to cell surface 0.023867324 21 NaN BCAM;CD151
epirubicin Anthracycline Yes MSN01 Up Beta-oxidation 0.021264329 18.5 NaN ACADM;ACADVL;DECR1
epirubicin Anthracycline Yes MSN09 Up Beta-oxidation 3.08E-05 3 NaN ACAA2;ACADM;ACADVL;DECR1;HADH;HADHA
epirubicin Anthracycline Yes MSN05 Up Biglycan synthesis 0.039608327 28.5 NaN BGN
epirubicin Anthracycline Yes MSN06 Up Biglycan synthesis 0.033874382 14 NaN BGN
epirubicin Anthracycline Yes MSN05 Up Cannabinoid receptor signaling 0.014455899 21 NaN CNR1;CNR2
epirubicin Anthracycline Yes MSN01 Down CCN intercellular signaling protein family receptor signaling 0.030931719 6.5 NaN CYR61
epirubicin Anthracycline Yes MSN05 Up Chaperone mediated protein folding in ER 0.007100524 10 NaN CANX;ERP29;FKBP10;PDIA3
epirubicin Anthracycline Yes MSN09 Up Chaperone mediated protein folding in ER 0.00889488 12 NaN CANX;CLGN;ERP29;PDIA3
epirubicin Anthracycline Yes MSN06 Down Cholesterol synthesis 0.015278792 4 NaN NSDHL;SQLE
epirubicin Anthracycline Yes MSN01 Down Chromatin organization by insulator proteins 0.018673895 4.5 NaN CTCF
epirubicin Anthracycline Yes MSN01 Down Chromatin targeting to lamina 0.006263232 2 NaN CTCF
epirubicin Anthracycline Yes MSN09 Up Citric acid cycle 0.001659686 9 NaN DLD;FH;PDHA1;PDHB
epirubicin Anthracycline Yes MSN05 Up Collagen fibril organization by fibril-associated bridges 0.021119418 23.5 NaN COL9A1;COL9A2
epirubicin Anthracycline Yes MSN06 Up Collagen fibril organization by fibril-associated bridges 0.015683041 9 NaN COL9A1;COL9A3
epirubicin Anthracycline Yes MSN09 Up Collagen fibril organization by fibril-associated bridges 0.023867324 21 NaN COL14A1;COL9A1
epirubicin Anthracycline Yes MSN01 Up Contractile ring constriction 0.013421778 15.5 NaN CDC42;MYLK
epirubicin Anthracycline Yes MSN05 Up Contractile ring constriction 0.014455899 21 NaN ANLN;MYLK
epirubicin Anthracycline Yes MSN01 Up Cytosolic protein folding 0.03810868 23 NaN HSP90AA1
epirubicin Anthracycline Yes MSN09 Up Cytosolic protein folding 0.042254764 26.5 NaN HSP90AA1
epirubicin Anthracycline Yes MSN01 Up Decorin synthesis 0.03810868 23 NaN DCN
epirubicin Anthracycline Yes MSN06 Up Decorin synthesis 0.033874382 14 NaN DCN
epirubicin Anthracycline Yes MSN09 Up Decorin synthesis 0.042254764 26.5 NaN DCN
epirubicin Anthracycline Yes MSN09 Up Electron transport chain 0.001188415 7 NaN COX7A1;NDUFA4;UQCR10;UQCR11
epirubicin Anthracycline Yes MSN05 Up Endogenous control of complement activity 0.014455899 21 NaN CD46;CD59
epirubicin Anthracycline Yes MSN09 Up Endogenous control of complement activity 0.016365818 18.5 NaN CD59;CFI
epirubicin Anthracycline Yes MSN01 Up Extracellular matrix breakdown by cathepsins 0.000363747 4.5 NaN CTSB;CTSF;CTSV;CTSZ
epirubicin Anthracycline Yes MSN05 Up Extracellular matrix breakdown by cathepsins 2.04E-05 1 NaN CTSB;CTSF;CTSL;CTSV;CTSZ
epirubicin Anthracycline Yes MSN06 Up Extracellular matrix breakdown by cathepsins 0.043022614 18 NaN CTSB;CTSF
epirubicin Anthracycline Yes MSN09 Up Extracellular matrix breakdown by cathepsins 2.79E-05 2 NaN CTSB;CTSF;CTSL;CTSV;CTSZ
epirubicin Anthracycline Yes MSN05 Up Extracellular matrix breakdown by heparanases and sulfatases 0.00890615 13.5 NaN SULF1;SULF2
epirubicin Anthracycline Yes MSN01 Up Extracellular matrix breakdown by matrix metalloproteases 0.043677795 26 NaN BSG;MMP2
epirubicin Anthracycline Yes MSN06 Up Extracellular matrix breakdown by matrix metalloproteases 0.002781922 6 NaN BSG;MMP14;MMP2
epirubicin Anthracycline Yes MSN01 Up Fibrillar collagen core structure organization 5.46E-07 1 NaN COL1A1;COL1A2;COL2A1;COL3A1;COL5A1;COL5A2
epirubicin Anthracycline Yes MSN05 Up Fibrillar collagen core structure organization 0.006014756 9 NaN COL11A1;COL2A1;COL5A2
epirubicin Anthracycline Yes MSN06 Up Fibrillar collagen core structure organization 2.72E-07 1 NaN COL11A2;COL1A1;COL1A2;COL2A1;COL3A1;COL5A1
epirubicin Anthracycline Yes MSN09 Up Fibrillar collagen core structure organization 0.000539428 4 NaN COL11A2;COL1A2;COL3A1;COL5A2
epirubicin Anthracycline Yes MSN06 Up Fibulin receptor signaling 0.001144587 5 NaN EFEMP2;FBLN1
epirubicin Anthracycline Yes MSN06 Down GABA-mediated control of postsynaptic potential 0.028312548 6 NaN GABARAP
epirubicin Anthracycline Yes MSN01 Down Glycogen synthesis and glycogenolysis 0.004385318 1 NaN PPP1R3B;PPP1R3C
epirubicin Anthracycline Yes MSN01 Up Glycolysis and Gluconeogenesis 0.010357425 14 NaN LDHB;PFKP;PGAM1;PGK1
epirubicin Anthracycline Yes MSN01 Up GPI-anchor synthesis and attachment to protein 0.009351581 13 NaN GPAA1;PIGS;PIGT
epirubicin Anthracycline Yes MSN05 Up GPI-anchor synthesis and attachment to protein 0.010395217 16.5 NaN PIGK;PIGS;PIGT
epirubicin Anthracycline Yes MSN09 Up GPI-anchor synthesis and attachment to protein 0.01239992 16 NaN PIGK;PIGS;PIGT
epirubicin Anthracycline Yes MSN05 Down Granulocyte macrophage colony-stimulating factor receptor signaling 0.009153673 2 NaN JUND
epirubicin Anthracycline Yes MSN09 Down Granulocyte macrophage colony-stimulating factor receptor signaling 0.002820997 1 NaN JUND
epirubicin Anthracycline Yes MSN09 Up Immunoproteasome organization 0.023867324 21 NaN PSME1;PSME2
epirubicin Anthracycline Yes MSN05 Up Inhibition of apoptosis 0.010395217 16.5 NaN BIRC5;IFI6;PEA15
epirubicin Anthracycline Yes MSN09 Down Insulin receptor signaling 0.020976416 5 NaN IRS2
epirubicin Anthracycline Yes MSN01 Down Integrin-mediated leukocyte rolling 0.043038559 9 NaN VCAM1
epirubicin Anthracycline Yes MSN01 Up Ketone body metabolism 0.03810868 23 NaN OXCT1
epirubicin Anthracycline Yes MSN05 Up Ketone body metabolism 0.039608327 28.5 NaN OXCT1
epirubicin Anthracycline Yes MSN06 Up Ketone body metabolism 0.033874382 14 NaN OXCT1
epirubicin Anthracycline Yes MSN09 Up Ketone body metabolism 0.042254764 26.5 NaN OXCT1
epirubicin Anthracycline Yes MSN09 Up Lamellipodium organization 0.036152236 24 NaN BRK1;EVL;MEMO1;RHOA
epirubicin Anthracycline Yes MSN09 Down Lamellipodium organization 0.041539781 6 NaN TIAM2
epirubicin Anthracycline Yes MSN06 Down Large ribosomal subunit organization 0.002316603 1 NaN RPL11;RPL3;RPL7A
epirubicin Anthracycline Yes MSN01 Down Leukocyte transmigration through endothelium 0.030931719 6.5 NaN VCAM1
epirubicin Anthracycline Yes MSN05 Up Lipid droplet fusion 0.039608327 28.5 NaN CIDEC
epirubicin Anthracycline Yes MSN01 Up Lipid droplet mitochondria interaction 0.004237163 8 NaN SCP2;SNAP23
epirubicin Anthracycline Yes MSN05 Up Lipid droplet mitochondria interaction 0.004572911 8 NaN SCP2;SNAP23
epirubicin Anthracycline Yes MSN09 Up Lipid droplet mitochondria interaction 0.005195699 10.5 NaN SCP2;SNAP23
epirubicin Anthracycline Yes MSN01 Up Lysosomal acidification 0.008260669 11 NaN ATP6AP1;ATP6AP2
epirubicin Anthracycline Yes MSN05 Up Lysosomal acidification 0.00890615 13.5 NaN ATP6AP1;ATP6AP2
epirubicin Anthracycline Yes MSN09 Up Lysosomal acidification 0.010100879 14 NaN ATP6AP1;ATP6AP2
epirubicin Anthracycline Yes MSN05 Up Lysosomal glycosaminoglycan degradation 0.00093277 6 NaN ARSB;GNS;IDS;SUMF1
epirubicin Anthracycline Yes MSN01 Up Lysosomal lipid degradation 2.94E-05 2.5 NaN ARSA;GALC;HEXA;PSAP
epirubicin Anthracycline Yes MSN05 Up Lysosomal lipid degradation 0.001128862 7 NaN GALC;HEXA;PSAP
epirubicin Anthracycline Yes MSN06 Up Lysosomal lipid degradation 0.000714731 4 NaN ARSA;HEXA;PSAP
epirubicin Anthracycline Yes MSN09 Up Lysosomal lipid degradation 0.001362806 8 NaN GALC;HEXA;PSAP
epirubicin Anthracycline Yes MSN01 Up Macroautophagy 0.038706404 25 NaN BECN1;MAP1LC3A;MAP1LC3B
epirubicin Anthracycline Yes MSN06 Up Macroautophagy 0.028661431 11 NaN BECN1;MAP1LC3A;MAP1LC3B
epirubicin Anthracycline Yes MSN05 Down Macrophage migration inhibitory factor signaling 0.022730297 3 NaN JUND
epirubicin Anthracycline Yes MSN09 Down Macrophage migration inhibitory factor signaling 0.007038508 2 NaN JUND
epirubicin Anthracycline Yes MSN05 Up Metabolism of branched-chain amino acids 0.028800167 25.5 NaN ACADSB;ECHS1
epirubicin Anthracycline Yes MSN09 Up Metabolism of branched-chain amino acids 2.58E-06 1 NaN ACAD8;ACADSB;ECHS1;HIBCH;MCCC1
epirubicin Anthracycline Yes MSN05 Down Myelin biogenesis and maturation 0.027215163 4 NaN PMP22
epirubicin Anthracycline Yes MSN05 Down Myofibril formation 0.000907157 1 NaN KLHL41;XIRP1
epirubicin Anthracycline Yes MSN09 Down Myofibril formation 0.014030551 4 NaN XIRP1
epirubicin Anthracycline Yes MSN01 Up Natriuretic peptide receptor signaling 0.01962834 17 NaN NPPA;NPPB
epirubicin Anthracycline Yes MSN05 Up Natriuretic peptide receptor signaling 0.021119418 23.5 NaN NPPA;NPPB
epirubicin Anthracycline Yes MSN09 Down Natriuretic peptide receptor signaling 0.008440625 3 NaN NPR3
epirubicin Anthracycline Yes MSN06 Down Necroptosis induction 0.00952717 3 NaN TNFRSF1A
epirubicin Anthracycline Yes MSN01 Up Non-vesicular phospholipid transport 0.026793551 20 NaN PITPNM1;SCP2
epirubicin Anthracycline Yes MSN05 Up Non-vesicular phospholipid transport 0.028800167 25.5 NaN PLTP;SCP2
epirubicin Anthracycline Yes MSN06 Up Non-vesicular phospholipid transport 0.021468498 10 NaN PITPNM1;SCP2
epirubicin Anthracycline Yes MSN01 Up Nucleosome assembly 0.04946113 27 NaN HIST2H2BE;HMGB1;TSPYL2
epirubicin Anthracycline Yes MSN06 Up Nucleosome assembly 0.036848196 17 NaN HIST1H1D;HIST1H1E;HIST2H2BE
epirubicin Anthracycline Yes MSN05 Up Osteonectin receptor signaling 0.00890615 13.5 NaN SPARC;SPOCK1
epirubicin Anthracycline Yes MSN01 Up Phase I biotransformation via alcohol dehydrogenases 0.008260669 11 NaN ALDH2;ALDH9A1
epirubicin Anthracycline Yes MSN09 Up Phase I biotransformation via alcohol dehydrogenases 0.010100879 14 NaN ALDH2;ALDH9A1
epirubicin Anthracycline Yes MSN06 Down Pre-mRNA capping 0.046744878 8.5 NaN CMTR2
epirubicin Anthracycline Yes MSN01 Down Protein acylation 0.018673895 4.5 NaN EP300
epirubicin Anthracycline Yes MSN06 Down Protein acylation 0.028312548 6 NaN NAA15
epirubicin Anthracycline Yes MSN09 Up Protein folding in mitochondria 0.005195699 10.5 NaN HSPD1;PPIF
epirubicin Anthracycline Yes MSN05 Up Protein N-linked glycosylation in ER 0.008029605 11 NaN DDOST;RPN2;TUSC3
epirubicin Anthracycline Yes MSN09 Up Protein N-linked glycosylation in ER 0.000819486 5.5 NaN DDOST;OSTC;RPN1;TUSC3
epirubicin Anthracycline Yes MSN01 Up Protein polyubiquitination 0.021264329 18.5 NaN NEDD8;SKP1;UCHL1
epirubicin Anthracycline Yes MSN09 Up Protein polyubiquitination 0.027852981 23 NaN NEDD8;SKP1;UCHL1
epirubicin Anthracycline Yes MSN06 Down Purinergic P1 receptor signaling 0.028312548 6 NaN ADORA1
epirubicin Anthracycline Yes MSN01 Up Pyrimidine synthesis and salvage 0.034835676 21 NaN TYMS;UPP1
epirubicin Anthracycline Yes MSN05 Up Retinol metabolism 0.013122147 18.5 NaN ALDH1A1;CYP26A1;RBP1
epirubicin Anthracycline Yes MSN05 Down RNA editing 0.044953641 6 NaN APOBEC2
epirubicin Anthracycline Yes MSN01 Down Selectin-mediated Leukocyte rolling 0.037003897 8 NaN VCAM1
epirubicin Anthracycline Yes MSN01 Down Sister chromatid cohesion 0.011407434 3 NaN NIPBL;SMC3
epirubicin Anthracycline Yes MSN06 Down Small ribosomal subunit organization 0.002566131 2 NaN RPS16;RPS4Y1;RPS7
epirubicin Anthracycline Yes MSN01 Up Syndecan receptor signaling 0.013421778 15.5 NaN SDC4;SDCBP
epirubicin Anthracycline Yes MSN06 Up Syndecan receptor signaling 0.010693605 8 NaN SDC4;SDCBP
epirubicin Anthracycline Yes MSN09 Up Syndecan receptor signaling 0.016365818 18.5 NaN SDC4;SDCBP
epirubicin Anthracycline Yes MSN05 Down Thin myofilament organization 0.031679842 5 NaN ACTA1
epirubicin Anthracycline Yes MSN05 Up Tropoelastin synthesis 0.039608327 28.5 NaN ELN
epirubicin Anthracycline Yes MSN06 Up Tropoelastin synthesis 0.033874382 14 NaN ELN
endothelin-1 Endogenous vasoconstrictor No MSN01 Up Mitotic spindle disassembly 0.023200423 13 NaN CDK1
endothelin-1 Endogenous vasoconstrictor No MSN02 Up Mitotic spindle disassembly 0.024788285 12.5 NaN CDK1
endothelin-1 Endogenous vasoconstrictor No MSN05 Up Mitotic spindle disassembly 0.024523641 10.5 NaN CDK1
endothelin-1 Endogenous vasoconstrictor No MSN08 Up Mitotic spindle disassembly 0.026287932 17 NaN CDK1
endothelin-1 Endogenous vasoconstrictor No MSN01 Up Natriuretic peptide receptor signaling 0.007562538 6 NaN NPPA;NPPB
endothelin-1 Endogenous vasoconstrictor No MSN02 Up Natriuretic peptide receptor signaling 0.008598393 5.5 NaN NPPA;NPR3
endothelin-1 Endogenous vasoconstrictor No MSN05 Up Natriuretic peptide receptor signaling 0.000276247 2 NaN NPPA;NPPB;NPR3
endothelin-1 Endogenous vasoconstrictor No MSN06 Up Natriuretic peptide receptor signaling 0.008598393 6.5 NaN NPPA;NPR3
endothelin-1 Endogenous vasoconstrictor No MSN08 Up Natriuretic peptide receptor signaling 0.000339137 7 NaN NPPA;NPPB;NPR3
endothelin-1 Endogenous vasoconstrictor No MSN02 Up Osteopontin receptor signaling 0.024788285 12.5 NaN SPP1
endothelin-1 Endogenous vasoconstrictor No MSN06 Up Osteopontin receptor signaling 0.024788285 11.5 NaN SPP1
endothelin-1 Endogenous vasoconstrictor No MSN01 Down Osteopontin receptor signaling 0.02196542 7.5 NaN SPP1
endothelin-1 Endogenous vasoconstrictor No MSN05 Down Osteopontin receptor signaling 0.02099506 9.5 NaN SPP1
endothelin-1 Endogenous vasoconstrictor No MSN05 Down Parathyroid hormone receptor signaling 0.0085983 6 NaN PTHLH;SLC9A3R1
endothelin-1 Endogenous vasoconstrictor No MSN01 Down Platelet-derived growth factor receptor signaling 0.001516175 3.5 NaN FOSL1;PDGFRA;PDGFRB
endothelin-1 Endogenous vasoconstrictor No MSN02 Down Platelet-derived growth factor receptor signaling 0.019010322 7.5 NaN PDGFRA;PDGFRB
endothelin-1 Endogenous vasoconstrictor No MSN05 Down Platelet-derived growth factor receptor signaling 0.001331035 3 NaN FOSL1;PDGFRA;PDGFRB
endothelin-1 Endogenous vasoconstrictor No MSN06 Down Platelet-derived growth factor receptor signaling 0.017285445 8.5 NaN PDGFRA;PDGFRB
endothelin-1 Endogenous vasoconstrictor No MSN08 Down Platelet-derived growth factor receptor signaling 0.000952391 3 NaN FOSL1;PDGFRA;PDGFRB
endothelin-1 Endogenous vasoconstrictor No MSN06 Up Prostaglandin E2 receptor signaling 0.008598393 6.5 NaN PTGER3;RAPGEF4
endothelin-1 Endogenous vasoconstrictor No MSN08 Up Prostaglandin E2 receptor signaling 0.009633191 12 NaN PTGER3;RAPGEF4
endothelin-1 Endogenous vasoconstrictor No MSN05 Down Prostaglandin PGF2 alpha receptor signaling 0.041551141 17 NaN PTGFR
endothelin-1 Endogenous vasoconstrictor No MSN08 Down Protein polyubiquitination 0.035163828 15 NaN UBC;UCHL1
endothelin-1 Endogenous vasoconstrictor No MSN01 Up Pyrimidine synthesis and salvage 0.013690263 8 NaN TK1;TYMP
endothelin-1 Endogenous vasoconstrictor No MSN08 Up Pyrimidine synthesis and salvage 0.017367241 14.5 NaN TK1;TYMP
endothelin-1 Endogenous vasoconstrictor No MSN01 Up Removal of caspase inhibition 0.045864587 17.5 NaN XAF1
endothelin-1 Endogenous vasoconstrictor No MSN02 Up Removal of caspase inhibition 0.048964244 18 NaN XAF1
endothelin-1 Endogenous vasoconstrictor No MSN05 Up Removal of caspase inhibition 0.048447984 17 NaN XAF1
endothelin-1 Endogenous vasoconstrictor No MSN06 Up Removal of caspase inhibition 0.048964244 16 NaN XAF1
endothelin-1 Endogenous vasoconstrictor No MSN01 Down Retinol metabolism 0.031958081 10.5 NaN ALDH1A1;ALDH1A3
endothelin-1 Endogenous vasoconstrictor No MSN05 Down Retinol metabolism 0.002236525 4 NaN ALDH1A1;ALDH1A3;DHRS3
endothelin-1 Endogenous vasoconstrictor No MSN08 Down Retinol metabolism 0.023708594 13 NaN ALDH1A1;ALDH1A3
endothelin-1 Endogenous vasoconstrictor No MSN02 Up Selectin-mediated Leukocyte rolling 0.008598393 5.5 NaN ICAM1;SELP
endothelin-1 Endogenous vasoconstrictor No MSN06 Up Selectin-mediated Leukocyte rolling 0.008598393 6.5 NaN ICAM1;SELP
endothelin-1 Endogenous vasoconstrictor No MSN01 Up Semaphorin signaling 0.043551421 15 NaN DPYSL4;FARP1;PLXND1
endothelin-1 Endogenous vasoconstrictor No MSN01 Down Serine and glycine metabolism 0.001516175 3.5 NaN PHGDH;PSAT1;SHMT2
endothelin-1 Endogenous vasoconstrictor No MSN05 Down Serine and glycine metabolism 0.021308064 12 NaN PHGDH;PSAT1
endothelin-1 Endogenous vasoconstrictor No MSN06 Down Serine and glycine metabolism 0.017285445 8.5 NaN PHGDH;SLC1A5
endothelin-1 Endogenous vasoconstrictor No MSN08 Down Serine and glycine metabolism 0.017132206 7 NaN PHGDH;PSAT1
endothelin-1 Endogenous vasoconstrictor No MSN05 Up Serotonin inactivation 0.048447984 17 NaN MAOA
endothelin-1 Endogenous vasoconstrictor No MSN01 Down Serotonin inactivation 0.043450255 15.5 NaN MAOA
endothelin-1 Endogenous vasoconstrictor No MSN02 Down Serotonin inactivation 0.039131362 14 NaN MAOA
endothelin-1 Endogenous vasoconstrictor No MSN06 Down Serotonin inactivation 0.037227967 15 NaN MAOB
endothelin-1 Endogenous vasoconstrictor No MSN02 Up Sister chromatid segregation 0.008598393 5.5 NaN ESPL1;TOP2A
endothelin-1 Endogenous vasoconstrictor No MSN01 Down Tight junction organization 0.037991607 12 NaN CLDN1;CLDN4;MYLK
endothelin-1 Endogenous vasoconstrictor No MSN01 Down Tropoelastin synthesis 0.02196542 7.5 NaN ELN
endothelin-1 Endogenous vasoconstrictor No MSN05 Down Tropoelastin synthesis 0.02099506 9.5 NaN ELN
endothelin-1 Endogenous vasoconstrictor No MSN06 Down Tropoelastin synthesis 0.018789697 11 NaN ELN
endothelin-1 Endogenous vasoconstrictor No MSN08 Down Tropoelastin synthesis 0.018701482 9.5 NaN ELN
endothelin-1 Endogenous vasoconstrictor No MSN01 Up Vasoactive intestinal peptide receptor signaling 0.045864587 17.5 NaN VIPR2
endothelin-1 Endogenous vasoconstrictor No MSN05 Up Vasoactive intestinal peptide receptor signaling 0.048447984 17 NaN VIPR2
endothelin-1 Endogenous vasoconstrictor No MSN02 Down Actin polymerization 0.049732167 17 NaN ACTA1;FMNL2;INF2
endothelin-1 Endogenous vasoconstrictor No MSN06 Up Adrenergic receptor signaling 0.025716112 13 NaN RAPGEF4;RASD1;RGS4
endothelin-1 Endogenous vasoconstrictor No MSN01 Up Aggrecan synthesis 0.023200423 13 NaN ACAN
endothelin-1 Endogenous vasoconstrictor No MSN02 Up Aggrecan synthesis 0.024788285 12.5 NaN ACAN
endothelin-1 Endogenous vasoconstrictor No MSN05 Up Aggrecan synthesis 0.024523641 10.5 NaN ACAN
endothelin-1 Endogenous vasoconstrictor No MSN06 Up Aggrecan synthesis 0.024788285 11.5 NaN ACAN
endothelin-1 Endogenous vasoconstrictor No MSN08 Up Aggrecan synthesis 0.026287932 17 NaN ACAN
endothelin-1 Endogenous vasoconstrictor No MSN01 Up Albumin mediated blood protein transport 0.023200423 13 NaN ALB
endothelin-1 Endogenous vasoconstrictor No MSN02 Up Albumin mediated blood protein transport 0.024788285 12.5 NaN ALB
endothelin-1 Endogenous vasoconstrictor No MSN08 Up Amyloid plaque organization 0.032389398 20 NaN APBB2;APOE
endothelin-1 Endogenous vasoconstrictor No MSN02 Down Amyloid plaque organization 0.019010322 7.5 NaN HSPB6;VSNL1
endothelin-1 Endogenous vasoconstrictor No MSN01 Up Antigen presentation via MHC class I molecules 0.021340058 10 NaN HLA-B;HLA-C
endothelin-1 Endogenous vasoconstrictor No MSN08 Up Antigen presentation via MHC class I molecules 0.026961659 19 NaN HLA-B;HLA-C
endothelin-1 Endogenous vasoconstrictor No MSN01 Down Biglycan synthesis 0.02196542 7.5 NaN BGN
endothelin-1 Endogenous vasoconstrictor No MSN02 Down Biglycan synthesis 0.019760056 9.5 NaN BGN
endothelin-1 Endogenous vasoconstrictor No MSN05 Down Biglycan synthesis 0.02099506 9.5 NaN BGN
endothelin-1 Endogenous vasoconstrictor No MSN06 Down Biglycan synthesis 0.018789697 11 NaN BGN
endothelin-1 Endogenous vasoconstrictor No MSN08 Down Biglycan synthesis 0.018701482 9.5 NaN BGN
endothelin-1 Endogenous vasoconstrictor No MSN02 Down Calcitonin receptor signaling 0.039131362 14 NaN RAMP1
endothelin-1 Endogenous vasoconstrictor No MSN08 Down Calcitonin receptor signaling 0.037054838 18.5 NaN RAMP1
endothelin-1 Endogenous vasoconstrictor No MSN06 Down Carnitine shuttle 0.006934528 5 NaN CPT1A;SLC25A20
endothelin-1 Endogenous vasoconstrictor No MSN05 Up CCN intercellular signaling protein family receptor signaling 0.005706386 7 NaN CTGF;CYR61
endothelin-1 Endogenous vasoconstrictor No MSN06 Up CCN intercellular signaling protein family receptor signaling 0.005827311 4 NaN CYR61;NOV
endothelin-1 Endogenous vasoconstrictor No MSN01 Down CD44-Mediated leukocyte rolling 0.043450255 15.5 NaN CD44
endothelin-1 Endogenous vasoconstrictor No MSN02 Down CD44-Mediated leukocyte rolling 0.039131362 14 NaN CD44
endothelin-1 Endogenous vasoconstrictor No MSN05 Down CD44-Mediated leukocyte rolling 0.041551141 17 NaN CD44
endothelin-1 Endogenous vasoconstrictor No MSN06 Down CD44-Mediated leukocyte rolling 0.037227967 15 NaN CD44
endothelin-1 Endogenous vasoconstrictor No MSN08 Down CD44-Mediated leukocyte rolling 0.037054838 18.5 NaN CD44
endothelin-1 Endogenous vasoconstrictor No MSN06 Up Cellular cholesterol uptake and efflux 0.039888032 14 NaN ABCA12;ARL4C
endothelin-1 Endogenous vasoconstrictor No MSN01 Down Cellular cholesterol uptake and efflux 0.031958081 10.5 NaN ABCA1;ABCG1
endothelin-1 Endogenous vasoconstrictor No MSN06 Down Cellular cholesterol uptake and efflux 0.001627653 2 NaN ABCA1;ABCG1;SCARA3
endothelin-1 Endogenous vasoconstrictor No MSN08 Down Cellular cholesterol uptake and efflux 0.023708594 13 NaN ABCA1;SCARA3
endothelin-1 Endogenous vasoconstrictor No MSN01 Down Cellular iron storage 0.001420807 2 NaN FTH1;FTL
endothelin-1 Endogenous vasoconstrictor No MSN05 Down Cellular iron storage 0.001298656 2 NaN FTH1;FTL
endothelin-1 Endogenous vasoconstrictor No MSN08 Down Cellular iron storage 0.001031479 4 NaN FTH1;FTL
endothelin-1 Endogenous vasoconstrictor No MSN05 Up Centrosome maturation 0.0336321 12.5 NaN PLK1;TPX2
endothelin-1 Endogenous vasoconstrictor No MSN08 Up Centrosome maturation 0.038203861 21.5 NaN PLK1;TPX2
endothelin-1 Endogenous vasoconstrictor No MSN01 Up Centrosome separation 0.021340058 10 NaN CDK1;NEK2
endothelin-1 Endogenous vasoconstrictor No MSN02 Up Centrosome separation 0.02416119 10 NaN CDK1;ESPL1
endothelin-1 Endogenous vasoconstrictor No MSN05 Up Centrosome separation 0.001540682 5 NaN CCNB1;CDK1;NEK2
endothelin-1 Endogenous vasoconstrictor No MSN08 Up Centrosome separation 8.67E-05 5 NaN CCNB1;CDK1;KIF11;NEK2
endothelin-1 Endogenous vasoconstrictor No MSN01 Down Chaperone-mediated autophagy 0.043450255 15.5 NaN HSPA8
endothelin-1 Endogenous vasoconstrictor No MSN02 Down Chaperone-mediated autophagy 0.039131362 14 NaN HSPA8
endothelin-1 Endogenous vasoconstrictor No MSN08 Down Chaperone-mediated autophagy 0.037054838 18.5 NaN HSP90AA1
endothelin-1 Endogenous vasoconstrictor No MSN06 Down Chloride transmembrane transport 0.023917892 13 NaN BEST1;SLC26A8
endothelin-1 Endogenous vasoconstrictor No MSN08 Down Chloride transmembrane transport 0.023708594 13 NaN BEST1;SLC26A8
endothelin-1 Endogenous vasoconstrictor No MSN01 Up Cholesterol synthesis 5.74E-12 1 NaN CYP51A1;DHCR24;DHCR7;FDFT1;FDPS;HMGCR;HMGCS1;MSMO1;MVD;NSDHL
endothelin-1 Endogenous vasoconstrictor No MSN02 Up Cholesterol synthesis 2.46E-13 1 NaN CYP51A1;DHCR24;DHCR7;FDFT1;FDPS;HMGCR;HMGCS1;LSS;MSMO1;MVD;SQLE
endothelin-1 Endogenous vasoconstrictor No MSN06 Up Cholesterol synthesis 2.46E-13 1 NaN CYP51A1;DHCR24;DHCR7;FDFT1;FDPS;HMGCR;HMGCS1;LSS;MSMO1;MVD;SQLE
endothelin-1 Endogenous vasoconstrictor No MSN08 Up Cholesterol synthesis 1.99E-08 1 NaN CYP51A1;DHCR24;DHCR7;FDPS;HMGCR;HMGCS1;MSMO1;MVD
endothelin-1 Endogenous vasoconstrictor No MSN02 Up Cholesterol-sensitive control of SREBP activation 0.008598393 5.5 NaN INSIG1;SREBF1
endothelin-1 Endogenous vasoconstrictor No MSN06 Up Cholesterol-sensitive control of SREBP activation 0.008598393 6.5 NaN INSIG1;SREBF1
endothelin-1 Endogenous vasoconstrictor No MSN06 Down Class switch recombination 0.048725822 17.5 NaN BCL6;IL7R
endothelin-1 Endogenous vasoconstrictor No MSN08 Down Class switch recombination 0.048315957 22.5 NaN BCL6;IL7R
endothelin-1 Endogenous vasoconstrictor No MSN01 Up Classical complement pathway 0.010426243 7 NaN C1QA;C1R
endothelin-1 Endogenous vasoconstrictor No MSN02 Up Classical complement pathway 1.22E-05 2 NaN C1QA;C1QB;C1QC;C1R
endothelin-1 Endogenous vasoconstrictor No MSN05 Up Classical complement pathway 0.000474665 3 NaN C1QB;C1QC;C1R
endothelin-1 Endogenous vasoconstrictor No MSN06 Up Classical complement pathway 1.22E-05 2 NaN C1QA;C1QB;C1QC;C1R
endothelin-1 Endogenous vasoconstrictor No MSN08 Up Classical complement pathway 1.54E-05 3 NaN C1QA;C1QB;C1QC;C1R
endothelin-1 Endogenous vasoconstrictor No MSN01 Up Collagen fiber crosslinking 0.005119846 5 NaN LOXL1;PXDN
endothelin-1 Endogenous vasoconstrictor No MSN08 Up Collagen fiber crosslinking 0.006535173 10.5 NaN LOXL1;PXDN
endothelin-1 Endogenous vasoconstrictor No MSN01 Down Collagen fibril organization by fibril-associated bridges 0.006799947 5 NaN COL14A1;COL9A2
endothelin-1 Endogenous vasoconstrictor No MSN02 Down Collagen fibril organization by fibril-associated bridges 0.005533298 2 NaN COL12A1;COL14A1
endothelin-1 Endogenous vasoconstrictor No MSN05 Down Collagen fibril organization by fibril-associated bridges 0.006227501 5 NaN COL14A1;COL9A2
endothelin-1 Endogenous vasoconstrictor No MSN06 Down Collagen fibril organization by fibril-associated bridges 0.005015101 4 NaN COL12A1;COL14A1
endothelin-1 Endogenous vasoconstrictor No MSN08 Down Collagen fibril organization by fibril-associated bridges 0.000123729 2 NaN COL12A1;COL14A1;COL9A2
endothelin-1 Endogenous vasoconstrictor No MSN08 Up Contractile ring constriction 0.006535173 10.5 NaN ANLN;ECT2
endothelin-1 Endogenous vasoconstrictor No MSN08 Down Cytosolic protein folding 0.018701482 9.5 NaN HSP90AA1
endothelin-1 Endogenous vasoconstrictor No MSN01 Down Decorin synthesis 0.02196542 7.5 NaN DCN
endothelin-1 Endogenous vasoconstrictor No MSN02 Down Decorin synthesis 0.019760056 9.5 NaN DCN
endothelin-1 Endogenous vasoconstrictor No MSN05 Down Decorin synthesis 0.02099506 9.5 NaN DCN
endothelin-1 Endogenous vasoconstrictor No MSN06 Down Decorin synthesis 0.018789697 11 NaN DCN
endothelin-1 Endogenous vasoconstrictor No MSN08 Down Decorin synthesis 0.018701482 9.5 NaN DCN
endothelin-1 Endogenous vasoconstrictor No MSN02 Up Desaturation of fatty acids 0.011841806 8 NaN FADS2;SCD
endothelin-1 Endogenous vasoconstrictor No MSN06 Up Desaturation of fatty acids 0.00048986 3 NaN FADS1;FADS2;SCD
endothelin-1 Endogenous vasoconstrictor No MSN06 Down Endogenous control of complement activity 0.003385224 3 NaN CFH;CFI
endothelin-1 Endogenous vasoconstrictor No MSN08 Down Endogenous control of complement activity 0.003354036 5 NaN CFH;CFI
endothelin-1 Endogenous vasoconstrictor No MSN05 Down Epithelial intermediate filament dynamics 0.011306612 7 NaN KRT19;KRT7
endothelin-1 Endogenous vasoconstrictor No MSN06 Down Epithelial intermediate filament dynamics 0.009132153 6 NaN KRT7;TCHH
endothelin-1 Endogenous vasoconstrictor No MSN08 Up Eukaryotic kinetochore dynamics 5.11E-06 2 NaN BUB1;CENPE;CENPF;CENPU;DYNLT3;NUF2;SPC24;TTK
endothelin-1 Endogenous vasoconstrictor No MSN02 Down Extracellular matrix breakdown and membrane shedding by adamalysins 0.01134371 4 NaN ADAMTS1;ADAMTS5;ADAMTS7
endothelin-1 Endogenous vasoconstrictor No MSN08 Down Extracellular matrix breakdown and membrane shedding by adamalysins 0.009769926 6 NaN ADAMTS1;ADAMTS14;ADAMTS5
endothelin-1 Endogenous vasoconstrictor No MSN02 Down Extracellular matrix breakdown by cathepsins 0.015757014 6 NaN CTSF;CTSV
endothelin-1 Endogenous vasoconstrictor No MSN06 Down Extracellular matrix breakdown by cathepsins 0.014318179 7 NaN CTSF;CTSL
endothelin-1 Endogenous vasoconstrictor No MSN02 Down Extracellular matrix breakdown by matrix metalloproteases 0.012770499 5 NaN MMP2;MMP3
endothelin-1 Endogenous vasoconstrictor No MSN01 Up Fibrillar collagen core structure organization 0.021340058 10 NaN COL2A1;COL5A1
endothelin-1 Endogenous vasoconstrictor No MSN02 Up Fibrillar collagen core structure organization 0.00158905 3 NaN COL11A2;COL2A1;COL5A1
endothelin-1 Endogenous vasoconstrictor No MSN05 Up Fibrillar collagen core structure organization 0.023680597 9 NaN COL2A1;COL5A1
endothelin-1 Endogenous vasoconstrictor No MSN06 Up Fibrillar collagen core structure organization 0.02416119 10 NaN COL2A1;COL5A1
endothelin-1 Endogenous vasoconstrictor No MSN08 Up Fibrillar collagen core structure organization 0.00188137 8 NaN COL11A2;COL2A1;COL5A1
endothelin-1 Endogenous vasoconstrictor No MSN01 Down Fibrillar collagen core structure organization 4.30E-05 1 NaN COL11A1;COL1A1;COL1A2;COL3A1
endothelin-1 Endogenous vasoconstrictor No MSN02 Down Fibrillar collagen core structure organization 2.84E-05 1 NaN COL1A1;COL1A2;COL3A1;COL5A2
endothelin-1 Endogenous vasoconstrictor No MSN05 Down Fibrillar collagen core structure organization 0.00098321 1 NaN COL1A1;COL1A2;COL3A1
endothelin-1 Endogenous vasoconstrictor No MSN06 Down Fibrillar collagen core structure organization 0.000712003 1 NaN COL1A1;COL1A2;COL3A1
endothelin-1 Endogenous vasoconstrictor No MSN08 Down Fibrillar collagen core structure organization 2.29E-05 1 NaN COL1A1;COL1A2;COL3A1;COL5A2
endothelin-1 Endogenous vasoconstrictor No MSN01 Up Fibulin receptor signaling 0.045864587 17.5 NaN FBLN1
endothelin-1 Endogenous vasoconstrictor No MSN05 Up Fibulin receptor signaling 0.048447984 17 NaN FBLN1
endothelin-1 Endogenous vasoconstrictor No MSN05 Up G2 M transition checkpoint 0.0336321 12.5 NaN CCNB1;CDK1
endothelin-1 Endogenous vasoconstrictor No MSN08 Up G2 M transition checkpoint 0.038203861 21.5 NaN CCNB1;CDK1
endothelin-1 Endogenous vasoconstrictor No MSN05 Down Gap junction organization 0.033831795 13.5 NaN GJA5;GJB2
endothelin-1 Endogenous vasoconstrictor No MSN02 Down Glutamate and glutamine metabolism 0.026271217 11 NaN SLC1A5;SLC7A5
endothelin-1 Endogenous vasoconstrictor No MSN01 Up Glycolysis and Gluconeogenesis 0.001770826 4 NaN ALDOA;ENO1;LDHA;PGK1
endothelin-1 Endogenous vasoconstrictor No MSN05 Up Glycolysis and Gluconeogenesis 0.000200326 1 NaN ENO1;HK2;LDHA;PGK1;TPI1
endothelin-1 Endogenous vasoconstrictor No MSN08 Up Glycolysis and Gluconeogenesis 2.17E-05 4 NaN ALDOA;ENO1;HK2;LDHA;PGK1;TPI1
endothelin-1 Endogenous vasoconstrictor No MSN02 Down Glycolysis and Gluconeogenesis 0.01007022 3 NaN PCK2;PFKFB3;PFKFB4
endothelin-1 Endogenous vasoconstrictor No MSN02 Up Granulocyte macrophage colony-stimulating factor receptor signaling 0.048964244 18 NaN JUND
endothelin-1 Endogenous vasoconstrictor No MSN05 Up Growth differentiation factor receptor signaling 0.015218327 8 NaN GDF2;GDF6
endothelin-1 Endogenous vasoconstrictor No MSN08 Up Growth differentiation factor receptor signaling 0.017367241 14.5 NaN GDF2;GDF6
endothelin-1 Endogenous vasoconstrictor No MSN06 Down Hedgehog receptor signaling 0.048725822 17.5 NaN BOC;GAS1
endothelin-1 Endogenous vasoconstrictor No MSN08 Down Hedgehog receptor signaling 0.048315957 22.5 NaN CDON;GAS1
endothelin-1 Endogenous vasoconstrictor No MSN01 Up Hepatocyte growth factor receptor signaling 0.045864587 17.5 NaN HGF
endothelin-1 Endogenous vasoconstrictor No MSN02 Up Hepatocyte growth factor receptor signaling 0.048964244 18 NaN HGF
endothelin-1 Endogenous vasoconstrictor No MSN05 Up Hepatocyte growth factor receptor signaling 0.048447984 17 NaN HGF
endothelin-1 Endogenous vasoconstrictor No MSN06 Up Hepatocyte growth factor receptor signaling 0.048964244 16 NaN HGF
endothelin-1 Endogenous vasoconstrictor No MSN01 Down Hepatocyte growth factor receptor signaling 0.043450255 15.5 NaN MET
endothelin-1 Endogenous vasoconstrictor No MSN05 Down Hepatocyte growth factor receptor signaling 0.041551141 17 NaN MET
endothelin-1 Endogenous vasoconstrictor No MSN08 Down Hepatocyte growth factor receptor signaling 0.037054838 18.5 NaN MET
endothelin-1 Endogenous vasoconstrictor No MSN08 Up Hyaluronan-mediated motility receptor signaling 0.026287932 17 NaN HMMR
endothelin-1 Endogenous vasoconstrictor No MSN02 Up Inhibin receptor signaling 0.0155326 9 NaN INHBA;INHBB
endothelin-1 Endogenous vasoconstrictor No MSN06 Up Inhibin receptor signaling 0.0155326 9 NaN INHBA;INHBB
endothelin-1 Endogenous vasoconstrictor No MSN01 Up Inhibition of apoptosis 0.000121035 2 NaN BIRC5;IFI6;PEA15;XAF1
endothelin-1 Endogenous vasoconstrictor No MSN02 Up Inhibition of apoptosis 0.03430279 15 NaN IFI6;XAF1
endothelin-1 Endogenous vasoconstrictor No MSN05 Up Inhibition of apoptosis 0.002723606 6 NaN BIRC5;IFI6;XAF1
endothelin-1 Endogenous vasoconstrictor No MSN08 Up Inhibition of apoptosis 0.003317085 9 NaN BIRC5;IFI6;XAF1
endothelin-1 Endogenous vasoconstrictor No MSN02 Up Inositol metabolism and transport 0.048964244 18 NaN SLC5A3
endothelin-1 Endogenous vasoconstrictor No MSN05 Down JAK-STAT signaling pathway 0.033831795 13.5 NaN SOCS3;STAT4
endothelin-1 Endogenous vasoconstrictor No MSN01 Up Lipogenesis 0.00053626 3 NaN ACLY;FASN
endothelin-1 Endogenous vasoconstrictor No MSN02 Up Lipogenesis 0.048964244 18 NaN FASN
endothelin-1 Endogenous vasoconstrictor No MSN05 Up Lipogenesis 0.000599299 4 NaN ACLY;FASN
endothelin-1 Endogenous vasoconstrictor No MSN06 Up Lipogenesis 0.048964244 16 NaN FASN
endothelin-1 Endogenous vasoconstrictor No MSN05 Up Metaphase to anaphase checkpoint 0.049939927 20 NaN BUB1;CCNB2;CDC20
endothelin-1 Endogenous vasoconstrictor No MSN08 Up Metaphase to anaphase checkpoint 0.011665755 13 NaN BUB1;CDC20;CENPE;TTK
endothelin-1 Endogenous vasoconstrictor No MSN01 Down Methionine cycle 0.043450255 15.5 NaN BHMT
endothelin-1 Endogenous vasoconstrictor No MSN05 Down Methionine cycle 0.041551141 17 NaN BHMT
endothelin-1 Endogenous vasoconstrictor No MSN08 Down Methionine cycle 0.037054838 18.5 NaN BHMT
endothelin-1 Endogenous vasoconstrictor No MSN01 Down Microfibril scaffold organization 0.043450255 15.5 NaN FBN1
endothelin-1 Endogenous vasoconstrictor No MSN02 Down Microfibril scaffold organization 0.039131362 14 NaN FBN1
endothelin-1 Endogenous vasoconstrictor No MSN05 Down Microfibril scaffold organization 0.041551141 17 NaN FBN1
endothelin-1 Endogenous vasoconstrictor No MSN06 Down Microfibril scaffold organization 0.037227967 15 NaN FBN1
endothelin-1 Endogenous vasoconstrictor No MSN08 Down Microfibril scaffold organization 0.037054838 18.5 NaN FBN1
endothelin-1 Endogenous vasoconstrictor No MSN05 Up Mitotic spindle assembly 0.039114857 14 NaN NUSAP1;TPX2
endothelin-1 Endogenous vasoconstrictor No MSN08 Up Mitotic spindle assembly 0.00027738 6 NaN DLGAP5;NUSAP1;TPX2;TTK
doxorubicin Anthracycline Yes MSN06 Down ER unfolded protein response pathway 0.027202094 10 NaN DDIT3
doxorubicin Anthracycline Yes MSN08 Down ER unfolded protein response pathway 0.024442263 9 NaN DDIT3
doxorubicin Anthracycline Yes MSN09 Up Extracellular matrix breakdown and membrane shedding by adamalysins 0.018322582 10.5 NaN ADAMTS15;ADAMTS17;ADAMTS7
doxorubicin Anthracycline Yes MSN09 Down Extracellular matrix breakdown and membrane shedding by adamalysins 0.000662661 2 NaN ADAMTS1;ADAMTS10;ADAMTS12;ADAMTS14
doxorubicin Anthracycline Yes MSN05 Down Extracellular matrix breakdown by matrix metalloproteases 0.032866596 15.5 NaN MMP1
doxorubicin Anthracycline Yes MSN06 Down Extracellular matrix breakdown by matrix metalloproteases 0.030551239 11 NaN MMP1
doxorubicin Anthracycline Yes MSN08 Down Extracellular matrix breakdown by matrix metalloproteases 0.027456433 10 NaN MMP1
doxorubicin Anthracycline Yes MSN09 Up Extracellular matrix breakdown by meprins 0.046726108 16 NaN MEP1A
doxorubicin Anthracycline Yes MSN05 Up Extracellular matrix breakdown by serine proteases 0.025301145 9 NaN HTRA1;ST14
doxorubicin Anthracycline Yes MSN08 Up Extracellular matrix breakdown by serine proteases 0.026677448 8 NaN HTRA1;ST14
doxorubicin Anthracycline Yes MSN06 Up Extrinsic apoptosis pathway 0.027730132 10.5 NaN TNFRSF10A;TNFRSF10B
doxorubicin Anthracycline Yes MSN09 Up Extrinsic apoptosis pathway 0.000426234 2 NaN FAS;TNFRSF10A;TNFRSF10B
doxorubicin Anthracycline Yes MSN05 Up Gap junction organization 0.013466483 7 NaN GJA5;GJB2;PRKCG
doxorubicin Anthracycline Yes MSN08 Up Gap junction organization 0.014531343 6 NaN GJA5;GJB2;PRKCG
doxorubicin Anthracycline Yes MSN09 Up Glutamate and glutamine metabolism 0.036581377 15 NaN GLS2;SLC1A5
doxorubicin Anthracycline Yes MSN09 Down Glycogen synthesis and glycogenolysis 0.029585472 11.5 NaN GYG2;PYGM
doxorubicin Anthracycline Yes MSN08 Up G-protein coupled receptor signaling pathway 0.03848067 14 NaN RGS16;RGS4;RGS5
doxorubicin Anthracycline Yes MSN09 Down Granulocyte macrophage colony-stimulating factor receptor signaling 0.033762424 14 NaN JAK2
doxorubicin Anthracycline Yes MSN06 Up Hedgehog receptor signaling 0.005455717 6 NaN FOXA2;MYCN;PTCH1;SHH
doxorubicin Anthracycline Yes MSN08 Up Hedgehog receptor signaling 0.033631101 9.5 NaN GAS1;MYCN;PTCH1
doxorubicin Anthracycline Yes MSN06 Down Heme degradation to bilirubin 0.010286538 3.5 NaN HMOX1
doxorubicin Anthracycline Yes MSN05 Down Hepatocyte growth factor receptor signaling 0.00739662 4.5 NaN MET
doxorubicin Anthracycline Yes MSN08 Down Hepatocyte growth factor receptor signaling 0.006165756 2.5 NaN MET
doxorubicin Anthracycline Yes MSN09 Down Hepatocyte growth factor receptor signaling 0.033762424 14 NaN MET
doxorubicin Anthracycline Yes MSN05 Down Hyaluronan receptor CD44 signaling 0.011074875 6.5 NaN CD44
doxorubicin Anthracycline Yes MSN06 Up Inhibin receptor signaling 0.036036556 12 NaN INHA;INHBB
doxorubicin Anthracycline Yes MSN09 Up Inositol metabolism and transport 0.000556884 3 NaN INPP5D;SLC5A3
doxorubicin Anthracycline Yes MSN09 Up Intrinsic apoptosis pathway 0.003920354 5 NaN BBC3;BIK;PMAIP1
doxorubicin Anthracycline Yes MSN05 Up Leukocyte transmigration through endothelium 0.012654774 5.5 NaN PECAM1;VCAM1
doxorubicin Anthracycline Yes MSN05 Up Lipid droplet fusion 0.036961891 11 NaN CIDEC
doxorubicin Anthracycline Yes MSN08 Up Lipid droplet fusion 0.038020466 12.5 NaN CIDEC
doxorubicin Anthracycline Yes MSN05 Down Microtubule crosslinking and bundling 0.022029985 11.5 NaN MAP2
doxorubicin Anthracycline Yes MSN06 Down Microtubule crosslinking and bundling 0.020469948 7.5 NaN MAP2
doxorubicin Anthracycline Yes MSN08 Down Microtubule crosslinking and bundling 0.018386674 7.5 NaN MAP2
doxorubicin Anthracycline Yes MSN06 Down Mitochondrial fission 0.040531407 14 NaN DNM1
doxorubicin Anthracycline Yes MSN09 Down Mitochondrial fission 0.017012043 9 NaN DNM1;MTFR2
doxorubicin Anthracycline Yes MSN06 Down Mitochondrial transport 0.033889149 12.5 NaN KIF1A
doxorubicin Anthracycline Yes MSN06 Up Mitotic spindle disassembly 0.038814397 13.5 NaN CDK1
doxorubicin Anthracycline Yes MSN09 Up Mitotic spindle disassembly 0.023641496 13 NaN CDK1
doxorubicin Anthracycline Yes MSN05 Up Muscarinic receptor signaling 0.018520889 8 NaN CHRM4;RGS5
doxorubicin Anthracycline Yes MSN08 Up Muscarinic receptor signaling 0.019542138 7 NaN RGS4;RGS5
doxorubicin Anthracycline Yes MSN09 Up Muscarinic receptor signaling 0.007844056 7 NaN CHRM4;RGS5
doxorubicin Anthracycline Yes MSN05 Up Natriuretic peptide receptor signaling 0.000922544 1 NaN NPPA;NPPB;NPPC
doxorubicin Anthracycline Yes MSN06 Up Natriuretic peptide receptor signaling 0.001064134 3 NaN NPPA;NPPB;NPPC
doxorubicin Anthracycline Yes MSN08 Up Natriuretic peptide receptor signaling 0.001001852 2 NaN NPPA;NPPB;NPPC
doxorubicin Anthracycline Yes MSN09 Down Natriuretic peptide receptor signaling 0.004135058 5 NaN NPPB;NPPC
doxorubicin Anthracycline Yes MSN06 Down Necroptosis induction 0.003440367 1 NaN TNFRSF1A
doxorubicin Anthracycline Yes MSN09 Down Neuregulin receptor signaling 0.014335775 8 NaN ERBB3;SH3TC2
doxorubicin Anthracycline Yes MSN05 Down NFkB signaling pathway 0.022029985 11.5 NaN SQSTM1
doxorubicin Anthracycline Yes MSN06 Down NFkB signaling pathway 0.020469948 7.5 NaN SQSTM1
doxorubicin Anthracycline Yes MSN08 Down NFkB signaling pathway 0.018386674 7.5 NaN SQSTM1
doxorubicin Anthracycline Yes MSN08 Up Nodal growth differentiation factor receptor signaling 0.001522291 3 NaN LEFTY1;LEFTY2;TGIF1;ZIC3
doxorubicin Anthracycline Yes MSN05 Up Nucleosome assembly 0.001053325 2 NaN ASF1B;BAZ1A;HIST1H1D;HIST1H1E;HIST2H2BE
doxorubicin Anthracycline Yes MSN06 Up Nucleosome assembly 0.001311187 4 NaN ASF1B;BAZ1A;HIST1H1D;HIST1H1E;HIST2H2BE
doxorubicin Anthracycline Yes MSN08 Up Nucleosome assembly 0.008745821 5 NaN ASF1B;HIST1H1D;HIST1H1E;HIST2H2BE
doxorubicin Anthracycline Yes MSN09 Up Nucleotide excision repair 0.000168813 1 NaN DDB2;PCNA;POLH;RPA1;XPC
doxorubicin Anthracycline Yes MSN09 Up Platelet-derived growth factor receptor signaling 0.026605409 14 NaN PDGFB;RGS5
doxorubicin Anthracycline Yes MSN05 Down Progestagen synthesis 0.014739823 8 NaN HSD17B2
doxorubicin Anthracycline Yes MSN06 Up Prostaglandin E2 receptor signaling 0.020324006 8.5 NaN PTGER2;PTGER4
doxorubicin Anthracycline Yes MSN05 Down Proteasomal regulatory particle organization 0.025655293 13.5 NaN PSMD14
doxorubicin Anthracycline Yes MSN06 Down Proteasomal regulatory particle organization 0.023841676 9 NaN PSMD14
doxorubicin Anthracycline Yes MSN09 Down Proteasomal regulatory particle organization 0.005724397 6.5 NaN PSMC4;PSMD14
doxorubicin Anthracycline Yes MSN05 Down Protein polyubiquitination 0.001556081 2 NaN UBC;UCHL1
doxorubicin Anthracycline Yes MSN08 Down Protein polyubiquitination 0.001081551 1 NaN UBC;UCHL1
doxorubicin Anthracycline Yes MSN09 Down Protein polyubiquitination 0.029585472 11.5 NaN UBC;UCHL1
doxorubicin Anthracycline Yes MSN06 Down Restriction point 0.033889149 12.5 NaN CDKN1A
doxorubicin Anthracycline Yes MSN08 Down Restriction point 0.030461556 11 NaN CDKN1A
doxorubicin Anthracycline Yes MSN09 Up Ribonucleotide reduction 0.001644513 4 NaN RRM2;RRM2B
doxorubicin Anthracycline Yes MSN06 Up Selectin-mediated Leukocyte rolling 0.020324006 8.5 NaN SELE;VCAM1
doxorubicin Anthracycline Yes MSN06 Up Syndecan receptor signaling 0.00054785 2 NaN SDC1;SDC4;SDCBP
doxorubicin Anthracycline Yes MSN05 Up Thick myofilament organization 0.003988825 4 NaN MYBPC3;MYH7
doxorubicin Anthracycline Yes MSN06 Up Thick myofilament organization 0.004393611 5 NaN MYBPC3;MYH7
doxorubicin Anthracycline Yes MSN08 Up Thick myofilament organization 0.004217801 4 NaN MYBPC3;MYH7
doxorubicin Anthracycline Yes MSN06 Up Thin myofilament organization 0.027730132 10.5 NaN TPM1;TPM2
doxorubicin Anthracycline Yes MSN09 Down Thin myofilament organization 0.005724397 6.5 NaN ACTA1;TNNI3
doxorubicin Anthracycline Yes MSN05 Down Transamination pathways 0.025655293 13.5 NaN BCAT1
doxorubicin Anthracycline Yes MSN06 Up Tropoelastin synthesis 0.038814397 13.5 NaN ELN
doxorubicin Anthracycline Yes MSN08 Up Tropoelastin synthesis 0.038020466 12.5 NaN ELN
doxorubicin Anthracycline Yes MSN05 Up WNT-Beta-catenin signaling pathway 0.002350796 3 NaN APCDD1;DKK2;DKK3;FZD1;FZD8;LEF1;SFRP5;WNT3A
doxorubicin Anthracycline Yes MSN06 Up WNT-Beta-catenin signaling pathway 5.28E-06 1 NaN APCDD1;AXIN2;DKK2;FRAT1;FZD1;FZD10;FZD7;FZD8;LEF1;MSX2;SFRP2;SFRP5
doxorubicin Anthracycline Yes MSN08 Up WNT-Beta-catenin signaling pathway 0.000136638 1 NaN APCDD1;AXIN2;DKK2;FZD1;FZD7;FZD8;LEF1;MSX2;SFRP2;SFRP5
doxorubicin Anthracycline Yes MSN09 Down Z-disc organization 0.00231055 3 NaN BAG3;LDB3;TCAP
doxorubicin Anthracycline Yes MSN09 Up Acetylcholine-mediated control of postsynaptic potential 0.010811186 8 NaN ACHE;AGRN
doxorubicin Anthracycline Yes MSN05 Down Androgen synthesis 0.032866596 15.5 NaN HSD17B2
doxorubicin Anthracycline Yes MSN05 Up Cannabinoid receptor signaling 0.012654774 5.5 NaN CNR1;CNR2
doxorubicin Anthracycline Yes MSN05 Up Cardiomyocyte pacemaker current generation 0.032920279 10 NaN CACNA1G;KCNJ5
doxorubicin Anthracycline Yes MSN08 Up Cardiomyocyte pacemaker current generation 0.034686748 11 NaN CACNA1G;KCNJ5
doxorubicin Anthracycline Yes MSN09 Up Cardiomyocyte pacemaker current generation 0.014191558 9 NaN CACNA1G;KCNJ5
doxorubicin Anthracycline Yes MSN05 Down CD44-Mediated leukocyte rolling 0.00739662 4.5 NaN CD44
doxorubicin Anthracycline Yes MSN09 Down CD44-Mediated leukocyte rolling 0.033762424 14 NaN CD44
doxorubicin Anthracycline Yes MSN09 Up Cell cycle arrest in response to DNA damage 0.018322582 10.5 NaN BBC3;CDKN1A;MDM2
doxorubicin Anthracycline Yes MSN05 Down Cellular iron storage 0.011074875 6.5 NaN FTL
doxorubicin Anthracycline Yes MSN06 Down Cellular iron storage 0.010286538 3.5 NaN FTL
doxorubicin Anthracycline Yes MSN08 Down Cellular iron storage 0.00923477 4 NaN FTL
doxorubicin Anthracycline Yes MSN09 Up Centrosome separation 0.022108594 12 NaN CDK1;CROCC
doxorubicin Anthracycline Yes MSN05 Down Chaperone-mediated autophagy 1.34E-05 1 NaN HSP90AA1;HSPA8
doxorubicin Anthracycline Yes MSN06 Down Chaperone-mediated autophagy 0.0068692 2 NaN HSPA8
doxorubicin Anthracycline Yes MSN08 Down Chaperone-mediated autophagy 0.006165756 2.5 NaN HSPA8
doxorubicin Anthracycline Yes MSN09 Down Chaperone-mediated autophagy 0.000288388 1 NaN HSP90AA1;HSPA8
doxorubicin Anthracycline Yes MSN08 Up Class switch recombination 0.033631101 9.5 NaN BCL6;IRF4;IRF8
doxorubicin Anthracycline Yes MSN09 Down Collagen fiber crosslinking 0.002787899 4 NaN PLOD1;PXDN
doxorubicin Anthracycline Yes MSN06 Up Contractile ring constriction 0.013904049 7 NaN ANLN;MYLK
doxorubicin Anthracycline Yes MSN05 Down Contractile ring constriction 0.018391511 9.5 NaN MYH14
doxorubicin Anthracycline Yes MSN06 Down Contractile ring constriction 0.017086874 5.5 NaN MYH14
doxorubicin Anthracycline Yes MSN08 Down Contractile ring constriction 0.015345202 5.5 NaN MYH14
doxorubicin Anthracycline Yes MSN05 Down Contractile ring formation 0.018391511 9.5 NaN MYH14
doxorubicin Anthracycline Yes MSN06 Down Contractile ring formation 0.017086874 5.5 NaN MYH14
doxorubicin Anthracycline Yes MSN08 Down Contractile ring formation 0.015345202 5.5 NaN MYH14
doxorubicin Anthracycline Yes MSN05 Down Cytosolic protein folding 0.003705011 3 NaN HSP90AA1
doxorubicin Anthracycline Yes MSN09 Down Cytosolic protein folding 0.017025406 10 NaN HSP90AA1
doxorubicin Anthracycline Yes MSN09 Up DNA replication elongation 0.005312003 6 NaN MCM4;PCNA
dobutamine Sympathomimetic No MSN05 Up Actin filament bundling and crosslinking 0.003112458 3 NaN EPS8;FLNA;TAGLN;USH1C
dobutamine Sympathomimetic No MSN08 Up Actin filament bundling and crosslinking 0.000322287 3 NaN EPS8;FLNA;FSCN2;TAGLN;USH1C
dobutamine Sympathomimetic No MSN01 Down Aggrecan synthesis 0.024964714 8 NaN ACAN
dobutamine Sympathomimetic No MSN05 Down Aggrecan synthesis 0.020465773 9 NaN ACAN
dobutamine Sympathomimetic No MSN06 Down Aggrecan synthesis 0.020289344 11.5 NaN ACAN
dobutamine Sympathomimetic No MSN08 Down Aggrecan synthesis 0.021524347 9.5 NaN ACAN
dobutamine Sympathomimetic No MSN09 Down Aggrecan synthesis 0.020553987 9.5 NaN ACAN
dobutamine Sympathomimetic No MSN05 Down Albumin mediated blood protein transport 0.020465773 9 NaN ALB
dobutamine Sympathomimetic No MSN06 Down Albumin mediated blood protein transport 0.020289344 11.5 NaN ALB
dobutamine Sympathomimetic No MSN08 Down Albumin mediated blood protein transport 0.021524347 9.5 NaN ALB
dobutamine Sympathomimetic No MSN08 Down Alternative complement pathway 0.004420469 5.5 NaN C1S;CFH
dobutamine Sympathomimetic No MSN06 Up Amyloid plaque organization 0.02587038 12.5 NaN APOE;HSPB6
dobutamine Sympathomimetic No MSN06 Down Bicarbonate transmembrane transport 0.006282675 6 NaN CA9;SLC26A7;SLC4A8
dobutamine Sympathomimetic No MSN01 Up Biglycan synthesis 0.018877911 6 NaN BGN
dobutamine Sympathomimetic No MSN05 Up Biglycan synthesis 0.023817925 9.5 NaN BGN
dobutamine Sympathomimetic No MSN06 Up Biglycan synthesis 0.023288638 10 NaN BGN
dobutamine Sympathomimetic No MSN08 Up Biglycan synthesis 0.023817925 11.5 NaN BGN
dobutamine Sympathomimetic No MSN09 Up Biglycan synthesis 0.023023994 7.5 NaN BGN
dobutamine Sympathomimetic No MSN01 Down Calcitonin receptor signaling 0.049308339 11 NaN RAMP1
dobutamine Sympathomimetic No MSN06 Down Cannabinoid receptor signaling 0.003936586 4.5 NaN CNR1;CNRIP1
dobutamine Sympathomimetic No MSN05 Up Cardiomyocyte repolarization during action potential and hyperpolarization 0.04259587 16.5 NaN KCNA1;KCNJ2
dobutamine Sympathomimetic No MSN08 Up Cardiomyocyte repolarization during action potential and hyperpolarization 0.04259587 17.5 NaN KCNA1;KCNJ2
dobutamine Sympathomimetic No MSN05 Up CCN intercellular signaling protein family receptor signaling 0.005389806 4 NaN CTGF;CYR61
dobutamine Sympathomimetic No MSN01 Down CCN intercellular signaling protein family receptor signaling 0.000148334 1 NaN CTGF;CYR61;NOV
dobutamine Sympathomimetic No MSN06 Down CCN intercellular signaling protein family receptor signaling 0.003936586 4.5 NaN CTGF;NOV
dobutamine Sympathomimetic No MSN08 Down CCN intercellular signaling protein family receptor signaling 0.004420469 5.5 NaN NOV;WISP1
dobutamine Sympathomimetic No MSN09 Down CCN intercellular signaling protein family receptor signaling 0.004038016 4 NaN CYR61;WISP1
dobutamine Sympathomimetic No MSN01 Up CD44-Mediated leukocyte rolling 0.037401081 9 NaN CD44
dobutamine Sympathomimetic No MSN06 Up Cellular cholesterol uptake and efflux 0.035587098 14 NaN ABCA1;ABCA12
dobutamine Sympathomimetic No MSN08 Up Cellular cholesterol uptake and efflux 0.037082638 15 NaN ABCA1;ABCA12
dobutamine Sympathomimetic No MSN08 Down Centrosome separation 0.018527793 8 NaN AURKA;NEK2
dobutamine Sympathomimetic No MSN06 Down Chloride transmembrane transport 0.027593758 13 NaN ANO1;SLC12A6
dobutamine Sympathomimetic No MSN01 Down Classical complement pathway 0.000500164 2 NaN C1QB;C1QC;C1R
dobutamine Sympathomimetic No MSN05 Down Classical complement pathway 0.008183872 5.5 NaN C1R;C1S
dobutamine Sympathomimetic No MSN05 Up Collagen fibril organization by fibril-associated bridges 0.007958007 5 NaN COL12A1;COL9A1
dobutamine Sympathomimetic No MSN08 Up Collagen fibril organization by fibril-associated bridges 0.000253405 2 NaN COL12A1;COL14A1;COL9A1
dobutamine Sympathomimetic No MSN01 Down Collagen fibril organization by fibril-associated bridges 0.0087173 6.5 NaN COL14A1;COL9A2
dobutamine Sympathomimetic No MSN09 Down Collagen fibril organization by fibril-associated bridges 0.005975135 5.5 NaN COL14A1;COL9A2
dobutamine Sympathomimetic No MSN01 Up Decorin synthesis 0.018877911 6 NaN DCN
dobutamine Sympathomimetic No MSN05 Down Decorin synthesis 0.020465773 9 NaN DCN
dobutamine Sympathomimetic No MSN09 Down Decorin synthesis 0.020553987 9.5 NaN DCN
dobutamine Sympathomimetic No MSN08 Up Discoidin domain receptor signaling 0.001668996 6 NaN DDR1;DDR2
dobutamine Sympathomimetic No MSN06 Up DNA replication elongation 0.005158008 4.5 NaN MCM5;MCM7
dobutamine Sympathomimetic No MSN06 Up DNA replication initiation 0.019672168 8 NaN CDC6;MCM5;MCM7
dobutamine Sympathomimetic No MSN09 Up ER unfolded protein response pathway 0.013492017 3 NaN DDIT3;PPP1R15A
dobutamine Sympathomimetic No MSN09 Down Myofibril formation 0.016979423 7 NaN DES;XIRP1
dobutamine Sympathomimetic No MSN01 Down Natriuretic peptide receptor signaling 0.0087173 6.5 NaN NPPA;NPR3
dobutamine Sympathomimetic No MSN09 Down Natriuretic peptide receptor signaling 0.005975135 5.5 NaN NPPA;NPPB
dobutamine Sympathomimetic No MSN05 Up NOD-like receptor signaling 0.037082638 14.5 NaN NLRP3;NOD2
dobutamine Sympathomimetic No MSN09 Up NOD-like receptor signaling 0.002908016 1 NaN NLRC5;NLRP3;NOD2
dobutamine Sympathomimetic No MSN08 Down Osteonectin receptor signaling 0.002690445 3.5 NaN SMOC2;SPARC
dobutamine Sympathomimetic No MSN09 Down Osteonectin receptor signaling 0.002456071 3 NaN SPARC;SPOCK1
dobutamine Sympathomimetic No MSN05 Up Osteopontin receptor signaling 0.023817925 9.5 NaN SPP1
dobutamine Sympathomimetic No MSN06 Up Osteopontin receptor signaling 0.023288638 10 NaN SPP1
dobutamine Sympathomimetic No MSN08 Up Osteopontin receptor signaling 0.023817925 11.5 NaN SPP1
dobutamine Sympathomimetic No MSN05 Up Platelet-derived growth factor receptor signaling 0.026976171 13 NaN FOSL1;PDGFRB
dobutamine Sympathomimetic No MSN06 Up Platelet-derived growth factor receptor signaling 0.02587038 12.5 NaN FOSL1;PDGFRA
dobutamine Sympathomimetic No MSN08 Up Platelet-derived growth factor receptor signaling 9.10E-05 1 NaN FOSL1;PDGFB;PDGFRA;PDGFRB
dobutamine Sympathomimetic No MSN09 Up Platelet-derived growth factor receptor signaling 0.025324824 9 NaN FOSL1;PDGFRB
dobutamine Sympathomimetic No MSN05 Up Progesterone receptor signaling 0.023817925 9.5 NaN PGR
dobutamine Sympathomimetic No MSN06 Up Prolactin receptor signaling 0.005158008 4.5 NaN PRLR;SOCS2
dobutamine Sympathomimetic No MSN09 Up Prostaglandin E2 receptor signaling 0.007451277 2 NaN PTGER3;RAPGEF4
dobutamine Sympathomimetic No MSN01 Down Removal of caspase inhibition 0.049308339 11 NaN XAF1
dobutamine Sympathomimetic No MSN05 Down Removal of caspase inhibition 0.040514466 13.5 NaN XAF1
dobutamine Sympathomimetic No MSN06 Down Removal of caspase inhibition 0.040168784 15 NaN XAF1
dobutamine Sympathomimetic No MSN08 Down Removal of caspase inhibition 0.042587255 12.5 NaN XAF1
dobutamine Sympathomimetic No MSN09 Down Removal of caspase inhibition 0.040687284 15 NaN XAF1
dobutamine Sympathomimetic No MSN09 Up Restriction point 0.021035933 5.5 NaN CDKN1A;E2F1
dobutamine Sympathomimetic No MSN08 Up Retinol metabolism 0.037082638 15 NaN RPE65;STRA6
dobutamine Sympathomimetic No MSN09 Up Retinol metabolism 0.034848653 10 NaN RPE65;STRA6
dobutamine Sympathomimetic No MSN01 Down Retinol metabolism 0.003656435 4 NaN ALDH1A3;CYP26A1;RBP1
dobutamine Sympathomimetic No MSN05 Down Retinol metabolism 0.002079214 3 NaN ALDH1A3;DHRS3;RBP1
dobutamine Sympathomimetic No MSN09 Down Retinol metabolism 0.028265172 11 NaN ALDH1A3;DHRS3
dobutamine Sympathomimetic No MSN06 Down Roundabout signaling 0.008047841 7 NaN ROBO1;ROBO2
dobutamine Sympathomimetic No MSN09 Down Semaphorin signaling 0.032121671 12 NaN NRP2;PLXNB3;RND1
dobutamine Sympathomimetic No MSN06 Down Serine and glycine metabolism 0.019981164 10 NaN PHGDH;SHMT2
dobutamine Sympathomimetic No MSN09 Down Serine and glycine metabolism 0.02047443 8 NaN PHGDH;SHMT2
dobutamine Sympathomimetic No MSN06 Up Serotonin inactivation 0.046036922 16.5 NaN MAOA
dobutamine Sympathomimetic No MSN09 Up Serotonin inactivation 0.045519869 11.5 NaN MAOA
dobutamine Sympathomimetic No MSN01 Down Serotonin inactivation 0.049308339 11 NaN MAOA
dobutamine Sympathomimetic No MSN05 Down Serotonin inactivation 0.040514466 13.5 NaN MAOB
dobutamine Sympathomimetic No MSN08 Down Serotonin inactivation 0.042587255 12.5 NaN MAOB
dobutamine Sympathomimetic No MSN05 Down Thin myofilament organization 0.008183872 5.5 NaN LMOD3;TPM4
dobutamine Sympathomimetic No MSN08 Down Thin myofilament organization 0.009022183 7 NaN LMOD3;TPM4
dobutamine Sympathomimetic No MSN05 Down Thrombospondin receptor signaling 0.002435279 4 NaN THBS2;THBS4
dobutamine Sympathomimetic No MSN06 Down Thrombospondin receptor signaling 0.002393952 3 NaN THBS2;THBS4
dobutamine Sympathomimetic No MSN08 Down Thrombospondin receptor signaling 0.002690445 3.5 NaN THBS2;THBS4
dobutamine Sympathomimetic No MSN01 Up Tropoelastin synthesis 0.018877911 6 NaN ELN
dobutamine Sympathomimetic No MSN05 Up Tropoelastin synthesis 0.023817925 9.5 NaN ELN
dobutamine Sympathomimetic No MSN06 Up Tropoelastin synthesis 0.023288638 10 NaN ELN
dobutamine Sympathomimetic No MSN08 Up Tropoelastin synthesis 0.023817925 11.5 NaN ELN
dobutamine Sympathomimetic No MSN09 Up Tropoelastin synthesis 0.023023994 7.5 NaN ELN
dobutamine Sympathomimetic No MSN05 Up Vasoactive intestinal peptide receptor signaling 0.047070608 19.5 NaN VIPR2
dobutamine Sympathomimetic No MSN05 Up Versican receptor signaling 0.047070608 19.5 NaN VCAN
dobutamine Sympathomimetic No MSN08 Up Versican receptor signaling 0.047070608 20.5 NaN VCAN
dobutamine Sympathomimetic No MSN05 Up Versican synthesis 0.023817925 9.5 NaN VCAN
dobutamine Sympathomimetic No MSN08 Up Versican synthesis 0.023817925 11.5 NaN VCAN
dobutamine Sympathomimetic No MSN01 Up WNT-Beta-catenin signaling pathway 0.007074109 4 NaN FRZB;FZD2;LEF1;SFRP2;WNT3A
dobutamine Sympathomimetic No MSN06 Up Extracellular matrix breakdown and membrane shedding by adamalysins 0.017608297 7 NaN ADAM15;ADAMTS12;ADAMTS14
dobutamine Sympathomimetic No MSN08 Up Extracellular matrix breakdown and membrane shedding by adamalysins 0.002296357 8 NaN ADAMTS1;ADAMTS14;ADAMTS4;ADAMTS5
dobutamine Sympathomimetic No MSN06 Down Extracellular matrix breakdown and membrane shedding by adamalysins 0.012182779 8 NaN ADAM33;ADAMTS2;ADAMTS5
dobutamine Sympathomimetic No MSN05 Down Extracellular matrix breakdown by cathepsins 0.016841612 7 NaN CTSF;CTSZ
dobutamine Sympathomimetic No MSN06 Down Extracellular matrix breakdown by cathepsins 0.016567476 9 NaN CTSF;CTSZ
dobutamine Sympathomimetic No MSN01 Up Extracellular matrix breakdown by matrix metalloproteases 0.000512369 2 NaN MMP12;MMP2;MMP3
dobutamine Sympathomimetic No MSN05 Up Extracellular matrix breakdown by matrix metalloproteases 0.001009123 1 NaN MMP12;MMP2;MMP3
dobutamine Sympathomimetic No MSN06 Up Extracellular matrix breakdown by matrix metalloproteases 0.000945368 2 NaN MMP12;MMP2;MMP3
dobutamine Sympathomimetic No MSN08 Up Extracellular matrix breakdown by matrix metalloproteases 0.001009123 4 NaN MMP12;MMP2;MMP3
dobutamine Sympathomimetic No MSN09 Up Extracellular matrix breakdown by matrix metalloproteases 0.017085597 4 NaN MMP12;MMP3
dobutamine Sympathomimetic No MSN01 Up Fibrillar collagen core structure organization 8.32E-09 1 NaN COL11A2;COL1A1;COL2A1;COL3A1;COL5A1;COL5A2
dobutamine Sympathomimetic No MSN05 Up Fibrillar collagen core structure organization 0.001416306 2 NaN COL11A2;COL2A1;COL5A2
dobutamine Sympathomimetic No MSN06 Up Fibrillar collagen core structure organization 5.41E-05 1 NaN COL11A1;COL11A2;COL2A1;COL5A2
dobutamine Sympathomimetic No MSN08 Up Fibrillar collagen core structure organization 0.001416306 5 NaN COL11A2;COL2A1;COL5A2
dobutamine Sympathomimetic No MSN09 Up Fibrillar collagen core structure organization 0.021035933 5.5 NaN COL11A2;COL2A1
dobutamine Sympathomimetic No MSN05 Down Fibrillar collagen core structure organization 3.26E-05 1 NaN COL1A1;COL1A2;COL3A1;COL5A3
dobutamine Sympathomimetic No MSN06 Down Fibrillar collagen core structure organization 0.00089029 2 NaN COL1A1;COL1A2;COL3A1
dobutamine Sympathomimetic No MSN08 Down Fibrillar collagen core structure organization 3.97E-05 1 NaN COL1A1;COL1A2;COL3A1;COL5A3
dobutamine Sympathomimetic No MSN09 Down Fibrillar collagen core structure organization 0.000924443 2 NaN COL1A1;COL1A2;COL3A1
dobutamine Sympathomimetic No MSN01 Up Fibroblast growth factor receptor signaling 0.020669774 8 NaN FGF1;FGF18
dobutamine Sympathomimetic No MSN06 Up Fibulin receptor signaling 0.046036922 16.5 NaN FBLN1
dobutamine Sympathomimetic No MSN08 Up Fibulin receptor signaling 0.047070608 20.5 NaN FBLN1
dobutamine Sympathomimetic No MSN05 Up Glucagon receptor signaling 0.023817925 9.5 NaN GCGR
dobutamine Sympathomimetic No MSN05 Up Glutamate and glutamine metabolism 0.037082638 14.5 NaN SLC1A3;SLC1A5
dobutamine Sympathomimetic No MSN08 Up Glutamate and glutamine metabolism 0.037082638 15 NaN SLC1A3;SLC38A2
dobutamine Sympathomimetic No MSN05 Down Glycogen synthesis and glycogenolysis 0.041446435 16 NaN PPP1R3A;PYGM
dobutamine Sympathomimetic No MSN08 Down Glycogen synthesis and glycogenolysis 0.045407974 15 NaN PPP1R3A;PYGM
dobutamine Sympathomimetic No MSN08 Up Glycolysis and Gluconeogenesis 0.001949718 7 NaN ENO1;HK2;PFKFB3;PFKFB4
dobutamine Sympathomimetic No MSN01 Down Granulocyte macrophage colony-stimulating factor receptor signaling 0.049308339 11 NaN JUND
dobutamine Sympathomimetic No MSN05 Down Granulocyte macrophage colony-stimulating factor receptor signaling 0.040514466 13.5 NaN JUND
dobutamine Sympathomimetic No MSN06 Down Granulocyte macrophage colony-stimulating factor receptor signaling 0.040168784 15 NaN JUND
dobutamine Sympathomimetic No MSN08 Down Granulocyte macrophage colony-stimulating factor receptor signaling 0.042587255 12.5 NaN JUND
dobutamine Sympathomimetic No MSN08 Up Growth differentiation factor receptor signaling 0.01439434 9 NaN GDF15;GDF6
dobutamine Sympathomimetic No MSN01 Up Hedgehog receptor signaling 0.04913699 10 NaN DHH;MYCN
dobutamine Sympathomimetic No MSN01 Down Hepatocyte growth factor receptor signaling 0.000621089 3 NaN HGF;MET
dobutamine Sympathomimetic No MSN05 Down Hepatocyte growth factor receptor signaling 0.000417079 2 NaN HGF;MET
dobutamine Sympathomimetic No MSN06 Down Hepatocyte growth factor receptor signaling 0.000409904 1 NaN HGF;MET
dobutamine Sympathomimetic No MSN08 Down Hepatocyte growth factor receptor signaling 0.000461439 2 NaN HGF;MET
dobutamine Sympathomimetic No MSN09 Down Hepatocyte growth factor receptor signaling 0.00042069 1 NaN HGF;MET
dobutamine Sympathomimetic No MSN05 Up Hippo signaling 0.023183885 6 NaN AMOTL1;FAT4;WWC1
dobutamine Sympathomimetic No MSN06 Up Histamine metabolism 0.046036922 16.5 NaN HNMT
dobutamine Sympathomimetic No MSN05 Down Inhibition of apoptosis 0.024046558 11 NaN IFI6;XAF1
dobutamine Sympathomimetic No MSN06 Up Interferon alpha receptor signaling 0.013789873 6 NaN IRF9;STAT1
dobutamine Sympathomimetic No MSN09 Down Intrinsic apoptosis pathway 0.032536263 13 NaN BCL2L1;BMF
dobutamine Sympathomimetic No MSN01 Up JAK-STAT signaling pathway 0.002070557 3 NaN SOCS2;STAT1;STAT4
dobutamine Sympathomimetic No MSN05 Up JAK-STAT signaling pathway 0.04259587 16.5 NaN SOCS2;STAT4
dobutamine Sympathomimetic No MSN06 Up JAK-STAT signaling pathway 0.003757771 3 NaN SOCS2;STAT1;STAT4
dobutamine Sympathomimetic No MSN08 Up JAK-STAT signaling pathway 0.04259587 17.5 NaN SOCS2;STAT4
dobutamine Sympathomimetic No MSN05 Up Lipogenesis 0.047070608 19.5 NaN FASN
dobutamine Sympathomimetic No MSN08 Up Lipogenesis 0.047070608 20.5 NaN FASN
dobutamine Sympathomimetic No MSN05 Up Methionine cycle 0.047070608 19.5 NaN BHMT
dobutamine Sympathomimetic No MSN06 Up Methionine cycle 0.046036922 16.5 NaN BHMT
dobutamine Sympathomimetic No MSN08 Up Methionine cycle 0.047070608 20.5 NaN BHMT
dobutamine Sympathomimetic No MSN09 Up Methionine cycle 0.045519869 11.5 NaN BHMT
dobutamine Sympathomimetic No MSN05 Down Microfibril scaffold organization 0.040514466 13.5 NaN FBN1
dobutamine Sympathomimetic No MSN06 Down Microfibril scaffold organization 0.040168784 15 NaN FBN1
dobutamine Sympathomimetic No MSN08 Down Microfibril scaffold organization 0.042587255 12.5 NaN FBN1
dobutamine Sympathomimetic No MSN09 Down Microfibril scaffold organization 0.040687284 15 NaN FBN1
dobutamine Sympathomimetic No MSN01 Down Mineralocorticoid receptor signaling 0.049308339 11 NaN GPER1
dobutamine Sympathomimetic No MSN09 Down Mineralocorticoid receptor signaling 0.040687284 15 NaN GPER1
dobutamine Sympathomimetic No MSN01 Down Z-disc organization 0.006773923 5 NaN DES;LDB3;TCAP
dobutamine Sympathomimetic No MSN09 Down Z-disc organization 0.041771182 17 NaN DES;MYPN
diclofenac Nsaid No MSN02 Down Z-disc organization 0.00389081 1 NaN CSRP3;DES;TCAP
diclofenac Nsaid No MSN06 Down Z-disc organization 0.003614093 1 NaN CSRP3;DES;TCAP
diclofenac Nsaid No MSN08 Down Z-disc organization 0.04507252 16 NaN DES;TCAP
diclofenac Nsaid No MSN09 Down Z-disc organization 0.035163828 12 NaN DES;TCAP
diclofenac Nsaid No MSN09 Down Mitotic spindle disassembly 0.018701482 7 NaN CDK1
diclofenac Nsaid No MSN05 Up Natriuretic peptide receptor signaling 0.007451277 9 NaN NPPB;NPR3
diclofenac Nsaid No MSN08 Up Natriuretic peptide receptor signaling 0.007730873 9 NaN NPPB;NPR3
diclofenac Nsaid No MSN06 Up Neuronal membrane repolarization during action potential and hyperpolarization 0.010261464 8 NaN KCNA1;KCNA4;KCNQ3
diclofenac Nsaid No MSN02 Down Osteopontin receptor signaling 0.020465773 6 NaN SPP1
diclofenac Nsaid No MSN05 Down Osteopontin receptor signaling 0.021612562 5 NaN SPP1
diclofenac Nsaid No MSN06 Down Osteopontin receptor signaling 0.019936486 8 NaN SPP1
diclofenac Nsaid No MSN08 Down Osteopontin receptor signaling 0.021436133 6 NaN SPP1
diclofenac Nsaid No MSN09 Up Perlecan synthesis 0.025935074 12.5 NaN HSPG2
diclofenac Nsaid No MSN01 Up Platelet-derived growth factor receptor signaling 0.001974848 4 NaN PDGFRB;RGS5;TNK2
diclofenac Nsaid No MSN02 Up Platelet-derived growth factor receptor signaling 0.002058855 4 NaN PDGFRB;RGS5;TNK2
diclofenac Nsaid No MSN05 Up Platelet-derived growth factor receptor signaling 0.001735926 4 NaN PDGFRB;RGS5;TNK2
diclofenac Nsaid No MSN06 Up Platelet-derived growth factor receptor signaling 0.002016575 4 NaN PDGFRB;RGS5;TNK2
diclofenac Nsaid No MSN08 Up Platelet-derived growth factor receptor signaling 8.59E-05 1 NaN PDGFB;PDGFRB;RGS5;TNK2
diclofenac Nsaid No MSN09 Up Platelet-derived growth factor receptor signaling 0.000126667 1 NaN PDGFB;PDGFRB;RGS5;TNK2
diclofenac Nsaid No MSN02 Down Platelet-derived growth factor receptor signaling 0.02030943 3.5 NaN FOSL1;PDGFRA
diclofenac Nsaid No MSN06 Down Platelet-derived growth factor receptor signaling 0.019331602 5.5 NaN FOSL1;PDGFRA
diclofenac Nsaid No MSN08 Down Platelet-derived growth factor receptor signaling 0.022155988 8.5 NaN PDGFD;PDGFRA
diclofenac Nsaid No MSN09 Down Platelet-derived growth factor receptor signaling 0.017132206 4.5 NaN FOSL1;PDGFRA
diclofenac Nsaid No MSN02 Up Progesterone receptor signaling 0.024435427 14.5 NaN PGR
diclofenac Nsaid No MSN09 Up Progesterone receptor signaling 0.025935074 12.5 NaN PGR
diclofenac Nsaid No MSN05 Up Prostaglandin PGF2 alpha receptor signaling 0.045519869 19 NaN PTGFR
diclofenac Nsaid No MSN06 Up Prostaglandin PGF2 alpha receptor signaling 0.047931585 17 NaN PTGFR
diclofenac Nsaid No MSN05 Up Retinol metabolism 0.034848653 14 NaN ALDH1A2;ALDH1A3
diclofenac Nsaid No MSN08 Up Retinol metabolism 0.036082859 14 NaN ALDH1A2;ALDH1A3
diclofenac Nsaid No MSN09 Up Retinol metabolism 0.043307043 17 NaN ALDH1A1;ALDH1A2
diclofenac Nsaid No MSN02 Down Retinol metabolism 0.028040621 10 NaN RDH10;TTR
diclofenac Nsaid No MSN05 Down Retinol metabolism 0.031017368 9 NaN ALDH1A1;TTR
diclofenac Nsaid No MSN06 Down Retinol metabolism 0.026709042 10.5 NaN RDH10;RPE65
diclofenac Nsaid No MSN08 Down Retinol metabolism 0.000126476 1 NaN ALDH1A1;RDH10;RPE65;TTR
diclofenac Nsaid No MSN01 Up Roundabout signaling 0.011202506 10.5 NaN ROBO1;ROBO2
diclofenac Nsaid No MSN02 Up Roundabout signaling 0.011520133 11 NaN ROBO1;ROBO2
diclofenac Nsaid No MSN05 Up Roundabout signaling 0.01027406 10 NaN ROBO1;ROBO2
diclofenac Nsaid No MSN06 Up Roundabout signaling 0.011360812 9.5 NaN ROBO1;ROBO2
diclofenac Nsaid No MSN08 Up Roundabout signaling 0.010656442 10 NaN ROBO1;ROBO2
diclofenac Nsaid No MSN05 Down Serotonin inactivation 0.042759886 12 NaN MAOA
diclofenac Nsaid No MSN06 Down Serotonin inactivation 0.039477231 13.5 NaN MAOA
diclofenac Nsaid No MSN08 Down Serotonin inactivation 0.042414608 14 NaN MAOA
diclofenac Nsaid No MSN02 Up Sulfonation 0.005666345 8 NaN SULT1A1;SULT1E1
diclofenac Nsaid No MSN08 Up Sulfonation 0.005234736 7.5 NaN SULT1A1;SULT1E1
diclofenac Nsaid No MSN01 Up Thrombospondin receptor signaling 0.003357826 5.5 NaN CD47;THBS2
diclofenac Nsaid No MSN02 Up Thrombospondin receptor signaling 0.003455479 5 NaN CD47;THBS2
diclofenac Nsaid No MSN05 Up Thrombospondin receptor signaling 0.003072996 5.5 NaN THBS1;THBS2
diclofenac Nsaid No MSN06 Up Thrombospondin receptor signaling 0.003406483 5 NaN CD47;THBS2
diclofenac Nsaid No MSN08 Up Thrombospondin receptor signaling 0.003190191 4.5 NaN THBS2;THBS4
diclofenac Nsaid No MSN09 Up Tropoelastin synthesis 0.025935074 12.5 NaN ELN
diclofenac Nsaid No MSN01 Down Vasoactive intestinal peptide receptor signaling 0.039995919 11 NaN VIPR2
diclofenac Nsaid No MSN02 Down WNT-Beta-catenin signaling pathway 0.041836543 15 NaN FRAT1;FRZB;PAX6;SFRP5
diclofenac Nsaid No MSN06 Down WNT-Beta-catenin signaling pathway 0.038589958 12 NaN FRAT1;FRZB;PAX6;SFRP5
diclofenac Nsaid No MSN09 Down WNT-Beta-catenin signaling pathway 0.031601666 11 NaN FRAT1;FRZB;PAX6;SFRP5
diclofenac Nsaid No MSN01 Up Aggrecan synthesis 0.024082569 15 NaN ACAN
diclofenac Nsaid No MSN02 Up Aggrecan synthesis 0.024435427 14.5 NaN ACAN
diclofenac Nsaid No MSN05 Up Aggrecan synthesis 0.023023994 12.5 NaN ACAN
diclofenac Nsaid No MSN06 Up Aggrecan synthesis 0.024258998 13 NaN ACAN
diclofenac Nsaid No MSN08 Up Aggrecan synthesis 0.023465067 13 NaN ACAN
diclofenac Nsaid No MSN09 Up Aggrecan synthesis 0.025935074 12.5 NaN ACAN
diclofenac Nsaid No MSN05 Up Albumin mediated blood protein transport 0.023023994 12.5 NaN ALB
diclofenac Nsaid No MSN01 Down Albumin mediated blood protein transport 0.020201129 7 NaN ALB
diclofenac Nsaid No MSN09 Down Albumin mediated blood protein transport 0.018701482 7 NaN ALB
diclofenac Nsaid No MSN01 Up Alternative complement pathway 0.005507519 9 NaN C1S;C3
diclofenac Nsaid No MSN02 Up Alternative complement pathway 0.005666345 8 NaN C1S;C3
diclofenac Nsaid No MSN05 Up Alternative complement pathway 0.005043927 7.5 NaN C1S;C3
diclofenac Nsaid No MSN06 Up Alternative complement pathway 0.005586664 7 NaN C1S;C3
diclofenac Nsaid No MSN09 Up Alternative complement pathway 0.006365168 5.5 NaN C1S;C3
diclofenac Nsaid No MSN01 Down Amyloid plaque organization 0.019817901 5 NaN APOE;HSPB6
diclofenac Nsaid No MSN02 Down Amyloid plaque organization 0.02030943 3.5 NaN APOE;HSPB6
diclofenac Nsaid No MSN05 Down Amyloid plaque organization 0.02249913 7 NaN APOE;HSPB6
diclofenac Nsaid No MSN06 Down Amyloid plaque organization 0.019331602 5.5 NaN APOE;HSPB6
diclofenac Nsaid No MSN08 Down Amyloid plaque organization 0.022155988 8.5 NaN APOE;HSPB6
diclofenac Nsaid No MSN09 Down Amyloid plaque organization 0.017132206 4.5 NaN APOE;HSPB6
diclofenac Nsaid No MSN01 Up Androgen receptor signaling 0.047587241 17.5 NaN AR
diclofenac Nsaid No MSN02 Up Androgen receptor signaling 0.048275867 17.5 NaN AR
diclofenac Nsaid No MSN05 Up Androgen receptor signaling 0.045519869 19 NaN AR
diclofenac Nsaid No MSN06 Up Androgen receptor signaling 0.047931585 17 NaN AR
diclofenac Nsaid No MSN01 Down Antigen presentation via MHC class I molecules 0.016431153 4 NaN HLA-B;HLA-C
diclofenac Nsaid No MSN02 Down Antigen presentation via MHC class I molecules 0.016841612 2 NaN HLA-B;HLA-C
diclofenac Nsaid No MSN05 Down Antigen presentation via MHC class I molecules 0.018671484 3 NaN HLA-B;HLA-C
diclofenac Nsaid No MSN06 Down Antigen presentation via MHC class I molecules 0.016025171 3.5 NaN HLA-B;HLA-C
diclofenac Nsaid No MSN08 Down Antigen presentation via MHC class I molecules 0.018384589 3.5 NaN HLA-B;HLA-C
diclofenac Nsaid No MSN09 Down Antigen presentation via MHC class I molecules 0.014190421 3 NaN HLA-B;HLA-C
diclofenac Nsaid No MSN09 Up Basement membrane assembly and organization 0.026291036 15.5 NaN COL4A1;HSPG2
diclofenac Nsaid No MSN01 Down Biglycan synthesis 0.020201129 7 NaN BGN
diclofenac Nsaid No MSN02 Down Biglycan synthesis 0.020465773 6 NaN BGN
diclofenac Nsaid No MSN05 Down Biglycan synthesis 0.021612562 5 NaN BGN
diclofenac Nsaid No MSN06 Down Biglycan synthesis 0.019936486 8 NaN BGN
diclofenac Nsaid No MSN08 Down Biglycan synthesis 0.021436133 6 NaN BGN
diclofenac Nsaid No MSN09 Down Biglycan synthesis 0.018701482 7 NaN BGN
diclofenac Nsaid No MSN01 Up Cardiomyocyte pacemaker current generation 0.014700929 12 NaN CACNA1G;KCNK2
diclofenac Nsaid No MSN02 Up Cardiomyocyte pacemaker current generation 0.015114208 13 NaN CACNA1G;KCNK2
diclofenac Nsaid No MSN06 Up Cardiomyocyte pacemaker current generation 0.014906928 11 NaN CACNA1G;KCNK2
diclofenac Nsaid No MSN08 Up Cardiomyocyte pacemaker current generation 0.000655562 3 NaN CACNA1D;CACNA1G;KCNK2
diclofenac Nsaid No MSN09 Up Cardiomyocyte pacemaker current generation 0.01692739 9 NaN CACNA1G;KCNK2
diclofenac Nsaid No MSN01 Up Cardiomyocyte repolarization during action potential and hyperpolarization 0.004129607 7.5 NaN KCNA1;KCNA4;KCNIP2
diclofenac Nsaid No MSN02 Up Cardiomyocyte repolarization during action potential and hyperpolarization 0.004301872 6 NaN KCNA1;KCNA4;KCNIP2
diclofenac Nsaid No MSN05 Up Cardiomyocyte repolarization during action potential and hyperpolarization 0.040050325 15.5 NaN KCNA1;KCNIP2
diclofenac Nsaid No MSN06 Up Cardiomyocyte repolarization during action potential and hyperpolarization 0.004215197 6 NaN KCNA1;KCNA4;KCNIP2
diclofenac Nsaid No MSN08 Up Cardiomyocyte repolarization during action potential and hyperpolarization 0.041456914 15 NaN KCNA1;KCNIP2
diclofenac Nsaid No MSN09 Up Cardiomyocyte repolarization during action potential and hyperpolarization 0.005083083 4 NaN KCNA1;KCNA4;KCNIP2
diclofenac Nsaid No MSN02 Up CCN intercellular signaling protein family receptor signaling 0.005666345 8 NaN CTGF;CYR61
diclofenac Nsaid No MSN05 Up CCN intercellular signaling protein family receptor signaling 0.005043927 7.5 NaN CTGF;WISP1
diclofenac Nsaid No MSN08 Up CCN intercellular signaling protein family receptor signaling 0.005234736 7.5 NaN CTGF;CYR61
diclofenac Nsaid No MSN09 Up CCN intercellular signaling protein family receptor signaling 0.006365168 5.5 NaN CTGF;CYR61
diclofenac Nsaid No MSN02 Down CD44-Mediated leukocyte rolling 0.040514466 13 NaN SPN
diclofenac Nsaid No MSN09 Down CD44-Mediated leukocyte rolling 0.037054838 13.5 NaN SPN
diclofenac Nsaid No MSN01 Down Cellular cholesterol uptake and efflux 0.02737145 9 NaN ABCA1;ABCG1
diclofenac Nsaid No MSN08 Down Cellular cholesterol uptake and efflux 0.03055135 11 NaN ABCA1;ABCG1
diclofenac Nsaid No MSN05 Down Cellular iron uptake and export 0.031017368 9 NaN CP;TFRC
diclofenac Nsaid No MSN08 Down Cellular iron uptake and export 0.03055135 11 NaN CD163;TFRC
diclofenac Nsaid No MSN06 Down Cholesterol-sensitive control of SREBP activation 0.0056301 2 NaN INSIG1;SREBF1
diclofenac Nsaid No MSN08 Down Cholesterol-sensitive control of SREBP activation 0.006484773 2 NaN INSIG1;SREBF1
diclofenac Nsaid No MSN01 Up Classical complement pathway 0.011202506 10.5 NaN C1R;C1S
diclofenac Nsaid No MSN02 Up Classical complement pathway 0.011520133 11 NaN C1R;C1S
diclofenac Nsaid No MSN06 Up Classical complement pathway 0.011360812 9.5 NaN C1R;C1S
diclofenac Nsaid No MSN09 Up Classical complement pathway 0.012914996 8 NaN C1R;C1S
diclofenac Nsaid No MSN01 Down Collagen fiber crosslinking 0.003903051 3 NaN LOX;LOXL1
diclofenac Nsaid No MSN01 Up Collagen fibril organization by fibril-associated bridges 4.75E-06 2 NaN COL12A1;COL14A1;COL19A1;COL9A3
diclofenac Nsaid No MSN02 Up Collagen fibril organization by fibril-associated bridges 5.04E-06 1 NaN COL12A1;COL14A1;COL19A1;COL9A3
diclofenac Nsaid No MSN05 Up Collagen fibril organization by fibril-associated bridges 3.97E-06 1 NaN COL12A1;COL14A1;COL19A1;COL9A3
diclofenac Nsaid No MSN06 Up Collagen fibril organization by fibril-associated bridges 4.89E-06 1 NaN COL12A1;COL14A1;COL19A1;COL9A3
diclofenac Nsaid No MSN08 Up Collagen fibril organization by fibril-associated bridges 0.000242463 2 NaN COL12A1;COL14A1;COL9A3
diclofenac Nsaid No MSN09 Up Collagen fibril organization by fibril-associated bridges 0.009384811 7 NaN COL12A1;COL14A1
diclofenac Nsaid No MSN01 Down Decorin synthesis 0.020201129 7 NaN DCN
diclofenac Nsaid No MSN02 Down Decorin synthesis 0.020465773 6 NaN DCN
diclofenac Nsaid No MSN05 Down Decorin synthesis 0.021612562 5 NaN DCN
diclofenac Nsaid No MSN06 Down Decorin synthesis 0.019936486 8 NaN DCN
diclofenac Nsaid No MSN08 Down Decorin synthesis 0.021436133 6 NaN DCN
diclofenac Nsaid No MSN02 Up Desaturation of fatty acids 0.011520133 11 NaN FADS2;SCD
diclofenac Nsaid No MSN01 Down Elastin cross-linking and assembly 0.001202742 2 NaN LOX;LOXL1
diclofenac Nsaid No MSN09 Up ER unfolded protein response pathway 0.000877812 2 NaN ATF4;HERPUD1;PPP1R15A
diclofenac Nsaid No MSN01 Down Eukaryotic kinetochore dynamics 0.040875895 13 NaN BUB1;CENPF;NDC80
diclofenac Nsaid No MSN09 Up Extracellular matrix breakdown by cathepsins 0.026291036 15.5 NaN CTSD;CTSF
diclofenac Nsaid No MSN06 Down Extracellular matrix breakdown by cathepsins 0.016025171 3.5 NaN CTSF;CTSH
diclofenac Nsaid No MSN09 Down Extracellular matrix breakdown by heparanases and sulfatases 0.002037514 2 NaN SULF1;SULF2
diclofenac Nsaid No MSN01 Up Extracellular matrix breakdown by matrix metalloproteases 0.018603478 13.5 NaN MMP1;MMP2
diclofenac Nsaid No MSN01 Up Fibrillar collagen core structure organization 1.78E-06 1 NaN COL11A1;COL1A1;COL2A1;COL5A2;COL5A3
diclofenac Nsaid No MSN02 Up Fibrillar collagen core structure organization 0.00152477 2 NaN COL11A1;COL2A1;COL5A3
diclofenac Nsaid No MSN05 Up Fibrillar collagen core structure organization 5.17E-05 2 NaN COL1A1;COL2A1;COL5A2;COL5A3
diclofenac Nsaid No MSN06 Up Fibrillar collagen core structure organization 0.023204138 12 NaN COL2A1;COL5A3
diclofenac Nsaid No MSN08 Up Fibrillar collagen core structure organization 0.021799773 12 NaN COL2A1;COL5A3
diclofenac Nsaid No MSN09 Up Fibrillar collagen core structure organization 0.001809764 3 NaN COL11A1;COL2A1;COL5A3
diclofenac Nsaid No MSN08 Down Fibrillar collagen core structure organization 0.018384589 3.5 NaN COL1A1;COL1A2
diclofenac Nsaid No MSN06 Up Fibrillin synthesis 0.001730983 2.5 NaN FBN1;FBN3
diclofenac Nsaid No MSN06 Up Fibroblast growth factor receptor signaling 0.032966818 14 NaN FGF10;FGF18
diclofenac Nsaid No MSN02 Down Fibroblast growth factor receptor signaling 0.024046558 8 NaN ANOS1;FGF7
diclofenac Nsaid No MSN09 Down Fibroblast growth factor receptor signaling 0.020308164 9 NaN ANOS1;FGF7
diclofenac Nsaid No MSN01 Up Fibulin receptor signaling 0.047587241 17.5 NaN FBLN1
diclofenac Nsaid No MSN02 Up Fibulin receptor signaling 0.048275867 17.5 NaN FBLN1
diclofenac Nsaid No MSN05 Up Fibulin receptor signaling 0.045519869 19 NaN FBLN1
diclofenac Nsaid No MSN06 Up Fibulin receptor signaling 0.047931585 17 NaN FBLN1
diclofenac Nsaid No MSN01 Down Glutamate and glutamine metabolism 0.000100501 1 NaN SLC1A3;SLC1A5;SLC38A2;SLC7A5
diclofenac Nsaid No MSN02 Down Glutamate and glutamine metabolism 0.028040621 10 NaN SLC1A5;SLC7A5
diclofenac Nsaid No MSN05 Down Glutamate and glutamine metabolism 0.00242926 1 NaN SLC1A3;SLC1A5;SLC7A5
diclofenac Nsaid No MSN06 Down Glutamate and glutamine metabolism 0.026709042 10.5 NaN SLC1A5;SLC7A5
diclofenac Nsaid No MSN09 Down Glutamate and glutamine metabolism 0.001605797 1 NaN SLC1A5;SLC38A2;SLC7A5
diclofenac Nsaid No MSN09 Up Glycolysis and Gluconeogenesis 0.020831213 10 NaN HK2;LDHA;PGK1
diclofenac Nsaid No MSN05 Down Granulocyte macrophage colony-stimulating factor receptor signaling 0.042759886 12 NaN JUND
diclofenac Nsaid No MSN01 Up Granulocyte-colony stimulating factor receptor signaling 0.018603478 13.5 NaN SOCS3;STAT3
diclofenac Nsaid No MSN05 Up Granulocyte-colony stimulating factor receptor signaling 0.017085597 11 NaN SOCS3;STAT3
diclofenac Nsaid No MSN08 Up Granulocyte-colony stimulating factor receptor signaling 0.017711138 11 NaN SOCS3;STAT3
diclofenac Nsaid No MSN01 Up Hepatocyte growth factor receptor signaling 0.047587241 17.5 NaN HGF
diclofenac Nsaid No MSN02 Up Hepatocyte growth factor receptor signaling 0.048275867 17.5 NaN HGF
diclofenac Nsaid No MSN05 Up Hepatocyte growth factor receptor signaling 0.045519869 19 NaN HGF
diclofenac Nsaid No MSN06 Up Hepatocyte growth factor receptor signaling 0.047931585 17 NaN HGF
diclofenac Nsaid No MSN08 Up Hepatocyte growth factor receptor signaling 0.046381546 16.5 NaN HGF
diclofenac Nsaid No MSN01 Up Inhibition of amyloid aggregation, amyloid degradation and uptake 0.001706055 3 NaN MME;PLAT
diclofenac Nsaid No MSN02 Up Inhibition of amyloid aggregation, amyloid degradation and uptake 0.001756088 3 NaN A2M;MME
diclofenac Nsaid No MSN05 Up Inhibition of amyloid aggregation, amyloid degradation and uptake 0.001560223 3 NaN A2M;MME
diclofenac Nsaid No MSN06 Up Inhibition of amyloid aggregation, amyloid degradation and uptake 0.001730983 2.5 NaN MME;PLAT
diclofenac Nsaid No MSN01 Up JAK-STAT signaling pathway 0.004129607 7.5 NaN SOCS2;SOCS3;STAT3
diclofenac Nsaid No MSN05 Up JAK-STAT signaling pathway 0.040050325 15.5 NaN SOCS3;STAT3
diclofenac Nsaid No MSN08 Up JAK-STAT signaling pathway 0.00383853 6 NaN SOCS2;SOCS3;STAT3
diclofenac Nsaid No MSN01 Up Leptin receptor signaling 0.003357826 5.5 NaN SOCS3;STAT3
diclofenac Nsaid No MSN05 Up Leptin receptor signaling 0.003072996 5.5 NaN SOCS3;STAT3
diclofenac Nsaid No MSN08 Up Leptin receptor signaling 0.003190191 4.5 NaN SOCS3;STAT3
diclofenac Nsaid No MSN01 Down Lipogenesis 0.039995919 11 NaN FASN
diclofenac Nsaid No MSN02 Down Lipogenesis 0.040514466 13 NaN FASN
diclofenac Nsaid No MSN05 Down Lipogenesis 0.042759886 12 NaN FASN
diclofenac Nsaid No MSN08 Down Lipogenesis 0.042414608 14 NaN FASN
diclofenac Nsaid No MSN05 Down Macrophage migration inhibitory factor signaling 0.004456057 2 NaN CXCR4;JUND
diclofenac Nsaid No MSN01 Down Methionine cycle 0.039995919 11 NaN BHMT
diclofenac Nsaid No MSN02 Down Methionine cycle 0.040514466 13 NaN BHMT
diclofenac Nsaid No MSN06 Down Methionine cycle 0.039477231 13.5 NaN BHMT
diclofenac Nsaid No MSN08 Down Methionine cycle 0.042414608 14 NaN BHMT
diclofenac Nsaid No MSN09 Down Methionine cycle 0.037054838 13.5 NaN BHMT
diclofenac Nsaid No MSN01 Up Microfibril scaffold organization 0.047587241 17.5 NaN FBN1
diclofenac Nsaid No MSN02 Up Microfibril scaffold organization 0.048275867 17.5 NaN FBN1
diclofenac Nsaid No MSN05 Up Microfibril scaffold organization 0.045519869 19 NaN FBN1
diclofenac Nsaid No MSN06 Up Microfibril scaffold organization 0.047931585 17 NaN FBN1
diclofenac Nsaid No MSN08 Up Microfibril scaffold organization 0.046381546 16.5 NaN FBN1
diclofenac Nsaid No MSN02 Down Mitotic spindle assembly 0.028040621 10 NaN NUSAP1;TPX2
diclofenac Nsaid No MSN05 Down Mitotic spindle assembly 0.031017368 9 NaN KIFC1;TPX2
diclofenac Nsaid No MSN08 Down Mitotic spindle assembly 0.03055135 11 NaN NUSAP1;TPX2
diclofenac Nsaid No MSN09 Down Mitotic spindle assembly 0.023708594 10 NaN NUSAP1;TPX2
delavirdine Antiviral No MSN06 Up Extracellular matrix breakdown and membrane shedding by adamalysins 0.009034585 5 NaN ADAM33;ADAMTS2;ADAMTS5
delavirdine Antiviral No MSN06 Down Extracellular matrix breakdown and membrane shedding by adamalysins 0.024408174 13.5 NaN ADAMTS14;ADAMTS4;ADAMTS7
delavirdine Antiviral No MSN09 Down Extracellular matrix breakdown and membrane shedding by adamalysins 0.027026538 9.5 NaN ADAM12;ADAMTS14;ADAMTS7
delavirdine Antiviral No MSN06 Down Extracellular matrix breakdown by cathepsins 0.027130428 17 NaN CTSD;CTSV
delavirdine Antiviral No MSN02 Up Extracellular matrix breakdown by matrix metalloproteases 0.015984742 14.5 NaN MMP1;MMP2
delavirdine Antiviral No MSN02 Down Extracellular matrix breakdown by matrix metalloproteases 0.01622657 10 NaN MMP7;MMP9
delavirdine Antiviral No MSN05 Down Extracellular matrix breakdown by matrix metalloproteases 0.000976912 1 NaN BSG;MMP7;MMP9
delavirdine Antiviral No MSN06 Down Extracellular matrix breakdown by matrix metalloproteases 0.022084252 12 NaN MMP12;MMP2
delavirdine Antiviral No MSN06 Up Fibrillar collagen core structure organization 0.013434638 7 NaN COL1A1;COL1A2
delavirdine Antiviral No MSN09 Up Fibrillar collagen core structure organization 0.000525812 2.5 NaN COL1A1;COL1A2;COL2A1
delavirdine Antiviral No MSN01 Down Fibrillar collagen core structure organization 9.13E-05 1 NaN COL1A1;COL1A2;COL2A1;COL3A1
delavirdine Antiviral No MSN06 Down Fibrillar collagen core structure organization 0.001899548 1 NaN COL11A1;COL2A1;COL5A2
delavirdine Antiviral No MSN09 Down Fibrillar collagen core structure organization 0.029190037 13 NaN COL11A1;COL5A2
delavirdine Antiviral No MSN09 Up Fibrillin synthesis 0.04996016 21 NaN FBN1
delavirdine Antiviral No MSN09 Up Fibronectin synthesis and extracellular assembly 0.0027595 6 NaN FN1;ITGB3
delavirdine Antiviral No MSN06 Down Filopodium organization 0.024408174 13.5 NaN ENAH;GPM6A;TNK2
delavirdine Antiviral No MSN09 Down Filopodium organization 0.027026538 9.5 NaN ENAH;GPM6A;TNK2
delavirdine Antiviral No MSN01 Down GABA metabolism 0.009884567 4 NaN ABAT;SLC6A1
delavirdine Antiviral No MSN02 Down GABA metabolism 0.007067944 8 NaN ABAT;SLC6A1
delavirdine Antiviral No MSN05 Down GABA metabolism 0.007787369 6 NaN ABAT;SLC6A1
delavirdine Antiviral No MSN02 Down Glutamate and glutamine metabolism 0.033150099 16 NaN SLC1A5;SLC7A5
delavirdine Antiviral No MSN05 Down Glutamate and glutamine metabolism 0.036331775 19 NaN SLC1A5;SLC7A5
delavirdine Antiviral No MSN08 Down Glutamate and glutamine metabolism 0.041452288 11 NaN SLC38A2;SLC7A5
delavirdine Antiviral No MSN02 Down Glycogen synthesis and glycogenolysis 0.048814568 23 NaN AGL;PYGM
delavirdine Antiviral No MSN02 Down Glycolysis and Gluconeogenesis 8.74E-06 1 NaN ENO1;HK2;LDHA;PCK2;PFKFB3;PFKFB4
delavirdine Antiviral No MSN05 Down Glycolysis and Gluconeogenesis 0.001871577 2 NaN HK2;LDHA;PFKFB3;PFKFB4
delavirdine Antiviral No MSN09 Down Glycolysis and Gluconeogenesis 0.003257229 3 NaN HK2;PCK2;PFKFB3;PFKFB4
delavirdine Antiviral No MSN02 Up Granulocyte-colony stimulating factor receptor signaling 0.015984742 14.5 NaN SOCS3;STAT3
delavirdine Antiviral No MSN06 Up Granulocyte-colony stimulating factor receptor signaling 0.010876887 6 NaN CSF3R;SOCS3
delavirdine Antiviral No MSN08 Up Granulocyte-colony stimulating factor receptor signaling 0.013881385 12 NaN SOCS3;STAT3
delavirdine Antiviral No MSN05 Down Granulocyte-colony stimulating factor receptor signaling 0.017837434 12 NaN CSF3R;INPP5D
delavirdine Antiviral No MSN08 Up Growth differentiation factor receptor signaling 0.010944482 10.5 NaN GDF2;GDF6
delavirdine Antiviral No MSN02 Down Growth differentiation factor receptor signaling 0.012808436 9 NaN GDF15;GDF2
delavirdine Antiviral No MSN05 Down Growth differentiation factor receptor signaling 0.014090651 10 NaN GDF15;GDF2
delavirdine Antiviral No MSN09 Up Heme degradation to bilirubin 0.04996016 21 NaN HMOX1
delavirdine Antiviral No MSN02 Up Hepatocyte growth factor receptor signaling 0.043967869 22.5 NaN MET
delavirdine Antiviral No MSN02 Down Hepatocyte growth factor receptor signaling 0.044312867 20.5 NaN HGF
delavirdine Antiviral No MSN05 Down Hepatocyte growth factor receptor signaling 0.046553835 24 NaN HGF
delavirdine Antiviral No MSN08 Down Hippo signaling 0.02715843 10 NaN AMOTL1;CRB2;WWC1
delavirdine Antiviral No MSN09 Down Hippo signaling 0.033358365 14 NaN AMOTL1;CRB2;WWC1
delavirdine Antiviral No MSN01 Up Inhibin receptor signaling 0.000346395 2 NaN INHBA;INHBE;TGFBR3
delavirdine Antiviral No MSN02 Up Inhibin receptor signaling 0.012616077 13 NaN INHBE;TGFBR3
delavirdine Antiviral No MSN05 Up Inhibin receptor signaling 0.010765432 11.5 NaN INHBE;TGFBR3
delavirdine Antiviral No MSN08 Up Inhibin receptor signaling 0.010944482 10.5 NaN INHBE;TGFBR3
delavirdine Antiviral No MSN09 Up Inhibition of amyloid aggregation, amyloid degradation and uptake 0.04996016 21 NaN A2M
delavirdine Antiviral No MSN01 Down Inhibition of amyloid aggregation, amyloid degradation and uptake 0.002084881 3 NaN MME;PLAT
delavirdine Antiviral No MSN06 Down Inhibition of amyloid aggregation, amyloid degradation and uptake 0.002043965 2 NaN MME;PLAT
delavirdine Antiviral No MSN08 Down Inhibition of amyloid aggregation, amyloid degradation and uptake 0.001884281 1 NaN MME;PLAT
delavirdine Antiviral No MSN02 Up Inhibition of apoptosis 0.02804976 19 NaN BIRC5;IFI6
delavirdine Antiviral No MSN05 Up Inhibition of apoptosis 0.024046558 17 NaN BIRC5;IFI6
delavirdine Antiviral No MSN09 Down Inhibition of apoptosis 0.04129959 17 NaN IFI6;XAF1
delavirdine Antiviral No MSN05 Down Inositol metabolism and transport 0.046553835 24 NaN INPP5D
delavirdine Antiviral No MSN09 Down Inositol metabolism and transport 0.00075031 2 NaN INPP5D;SLC5A3
delavirdine Antiviral No MSN01 Up JAK-STAT signaling pathway 0.027804205 15 NaN SOCS2;SOCS3
delavirdine Antiviral No MSN02 Up JAK-STAT signaling pathway 0.037567125 21 NaN SOCS3;STAT3
delavirdine Antiviral No MSN08 Up JAK-STAT signaling pathway 0.032793723 18 NaN SOCS3;STAT3
delavirdine Antiviral No MSN02 Down JAK-STAT signaling pathway 0.038113484 17 NaN SOCS2;STAT4
delavirdine Antiviral No MSN02 Up Leptin receptor signaling 0.002867401 5 NaN SOCS3;STAT3
delavirdine Antiviral No MSN08 Up Leptin receptor signaling 0.002476949 2.5 NaN SOCS3;STAT3
delavirdine Antiviral No MSN09 Up Lipogenesis 0.033588983 16.5 NaN FASN
delavirdine Antiviral No MSN01 Up Macrophage migration inhibitory factor signaling 0.003416552 5 NaN ACKR3;CXCR4
delavirdine Antiviral No MSN02 Up Macrophage migration inhibitory factor signaling 0.004708979 7.5 NaN ACKR3;CXCR4
delavirdine Antiviral No MSN05 Up Macrophage migration inhibitory factor signaling 0.004004069 3.5 NaN ACKR3;CXCR4
delavirdine Antiviral No MSN08 Up Macrophage migration inhibitory factor signaling 0.004072101 5 NaN ACKR3;CXCR4
delavirdine Antiviral No MSN09 Up Macrophage migration inhibitory factor signaling 0.0027595 6 NaN ACKR3;CXCR4
delavirdine Antiviral No MSN08 Up Metaphase to anaphase checkpoint 0.032473286 17 NaN CCNB2;CDC20;PTTG1
delavirdine Antiviral No MSN01 Up Microfibril scaffold organization 0.037401081 17 NaN FBN1
delavirdine Antiviral No MSN02 Up Microfibril scaffold organization 0.000492258 2 NaN FBN1;MFAP2
delavirdine Antiviral No MSN05 Up Microfibril scaffold organization 0.000417079 1 NaN FBN1;MFAP2
delavirdine Antiviral No MSN06 Up Microfibril scaffold organization 0.036015735 13 NaN FBN1
delavirdine Antiviral No MSN08 Up Microfibril scaffold organization 0.040860087 20 NaN FBN1
delavirdine Antiviral No MSN09 Up Microfibril scaffold organization 0.033588983 16.5 NaN FBN1
delavirdine Antiviral No MSN06 Down Muscarinic receptor signaling 0.009695754 7 NaN CHRM4;RGS5
delavirdine Antiviral No MSN01 Up Natriuretic peptide receptor signaling 0.005061213 7.5 NaN NPPA;NPPB
delavirdine Antiviral No MSN02 Up Natriuretic peptide receptor signaling 0.006960163 11 NaN NPPB;NPR3
delavirdine Antiviral No MSN05 Up Natriuretic peptide receptor signaling 0.005925252 6.5 NaN NPPB;NPR3
delavirdine Antiviral No MSN06 Down Natriuretic peptide receptor signaling 0.009695754 7 NaN NPPA;NPPB
delavirdine Antiviral No MSN09 Down Natriuretic peptide receptor signaling 0.010461076 5 NaN NPPA;NPPB
delavirdine Antiviral No MSN06 Up Necroptosis induction 0.018172195 9 NaN TNFRSF1A
delavirdine Antiviral No MSN09 Down Neuregulin receptor signaling 0.0350401 15.5 NaN ERBB3;NRG1
delavirdine Antiviral No MSN05 Down Notch receptor signaling 0.01094832 8.5 NaN DLK1;JAG1;LFNG
delavirdine Antiviral No MSN09 Down Notch receptor signaling 0.000166205 1 NaN DLK1;JAG1;JAG2;LFNG;MIB2
delavirdine Antiviral No MSN06 Up Osteonectin receptor signaling 0.001924922 2.5 NaN SMOC2;SPARC
delavirdine Antiviral No MSN08 Up Osteonectin receptor signaling 0.002476949 2.5 NaN SPARC;SPOCK1
delavirdine Antiviral No MSN09 Up Osteonectin receptor signaling 0.001674362 4 NaN SMOC2;SPARC
delavirdine Antiviral No MSN01 Up Osteopontin receptor signaling 0.018877911 11.5 NaN SPP1
delavirdine Antiviral No MSN05 Up Osteopontin receptor signaling 0.020465773 15.5 NaN SPP1
delavirdine Antiviral No MSN08 Up Osteopontin receptor signaling 0.020642202 14.5 NaN SPP1
delavirdine Antiviral No MSN09 Up Osteopontin receptor signaling 0.016937191 13 NaN SPP1
delavirdine Antiviral No MSN02 Down Osteopontin receptor signaling 0.022406493 12.5 NaN SPP1
delavirdine Antiviral No MSN06 Down Osteopontin receptor signaling 0.026376147 15.5 NaN SPP1
delavirdine Antiviral No MSN01 Down Platelet-derived growth factor receptor signaling 0.033195907 11.5 NaN PDGFRA;PDGFRB
delavirdine Antiviral No MSN06 Down Platelet-derived growth factor receptor signaling 0.002561173 3 NaN PDGFRA;RGS5;TNK2
delavirdine Antiviral No MSN09 Down Platelet-derived growth factor receptor signaling 0.0350401 15.5 NaN PDGFRA;TNK2
delavirdine Antiviral No MSN05 Down Potassium transmembrane transport 0.018142498 13 NaN ATP1A3;KCNE4;KCNK2
delavirdine Antiviral No MSN02 Up Progesterone receptor signaling 0.022230064 17.5 NaN PGR
delavirdine Antiviral No MSN02 Down Prostacycline receptor signaling 0.044312867 20.5 NaN PTGIR
delavirdine Antiviral No MSN06 Down Proteasomal regulatory particle organization 0.013338981 10 NaN PSMC4;PSMD14
delavirdine Antiviral No MSN02 Up Protein polyubiquitination 0.004906048 10 NaN ISG15;UBC;UCHL1
delavirdine Antiviral No MSN05 Up Protein polyubiquitination 0.041446435 22 NaN UBC;UCHL1
delavirdine Antiviral No MSN08 Up Protein polyubiquitination 0.042096917 22 NaN UBC;UCHL1
delavirdine Antiviral No MSN02 Down Removal of caspase inhibition 0.044312867 20.5 NaN XAF1
delavirdine Antiviral No MSN05 Down Removal of caspase inhibition 0.046553835 24 NaN XAF1
delavirdine Antiviral No MSN08 Down Removal of caspase inhibition 0.049996342 12.5 NaN XAF1
delavirdine Antiviral No MSN01 Up Retinol metabolism 0.024127969 13.5 NaN ALDH1A1;STRA6
delavirdine Antiviral No MSN02 Up Retinol metabolism 0.002632093 4 NaN ALDH1A1;ALDH1A3;STRA6
delavirdine Antiviral No MSN05 Up Retinol metabolism 0.028040621 18.5 NaN ALDH1A1;STRA6
delavirdine Antiviral No MSN01 Down Retinol metabolism 0.045465381 13 NaN DHRS3;RLBP1
delavirdine Antiviral No MSN02 Down Retinol metabolism 0.002691927 2 NaN ALDH1A2;DHRS3;RLBP1
delavirdine Antiviral No MSN05 Down Retinol metabolism 0.0031016 3 NaN ALDH1A2;DHRS3;RLBP1
delavirdine Antiviral No MSN08 Down Retinol metabolism 0.00380409 3 NaN ALDH1A3;DHRS3;RLBP1
delavirdine Antiviral No MSN09 Down Retinol metabolism 0.047941794 18 NaN DHRS3;RLBP1
delavirdine Antiviral No MSN02 Down Semaphorin signaling 0.006731385 7 NaN CRMP1;DPYSL2;DPYSL4;SEMA6B
delavirdine Antiviral No MSN05 Down Semaphorin signaling 0.045211705 21 NaN CRMP1;DPYSL4;SEMA6B
delavirdine Antiviral No MSN09 Down Semaphorin signaling 0.013476514 6 NaN CRMP1;DPYSL4;PLXNC1;SEMA6B
delavirdine Antiviral No MSN01 Up Serine and glycine metabolism 0.017439282 10 NaN PHGDH;SHMT2
delavirdine Antiviral No MSN05 Up Serine and glycine metabolism 0.02030943 14 NaN PHGDH;SHMT2
delavirdine Antiviral No MSN08 Up Serine and glycine metabolism 0.020640007 13 NaN PHGDH;SHMT2
delavirdine Antiviral No MSN09 Up Serine and glycine metabolism 0.01419473 10.5 NaN PHGDH;SHMT2
delavirdine Antiviral No MSN01 Down Serine and glycine metabolism 0.033195907 11.5 NaN PSAT1;SLC1A5
delavirdine Antiviral No MSN02 Down Serine and glycine metabolism 0.02407108 15 NaN PSAT1;SLC1A5
delavirdine Antiviral No MSN05 Down Serine and glycine metabolism 0.026420838 18 NaN PSAT1;SLC1A5
delavirdine Antiviral No MSN01 Up Serotonin inactivation 0.000354742 3 NaN MAOA;MAOB
delavirdine Antiviral No MSN05 Up Serotonin inactivation 0.040514466 20.5 NaN MAOA
delavirdine Antiviral No MSN08 Up Serotonin inactivation 0.040860087 20 NaN MAOA
delavirdine Antiviral No MSN02 Down Serotonin inactivation 0.044312867 20.5 NaN MAOA
delavirdine Antiviral No MSN08 Up Sister chromatid segregation 0.006025215 7.5 NaN ESPL1;PTTG1
delavirdine Antiviral No MSN02 Down Syndecan ectodomain shedding 0.002912493 3.5 NaN MMP7;MMP9
delavirdine Antiviral No MSN05 Down Syndecan ectodomain shedding 0.003213885 4 NaN MMP7;MMP9
delavirdine Antiviral No MSN05 Down Thin myofilament organization 0.010733686 7 NaN ACTA1;TNNI3
delavirdine Antiviral No MSN06 Up Thrombospondin receptor signaling 0.001924922 2.5 NaN THBS2;THBS4
delavirdine Antiviral No MSN02 Down Thrombospondin receptor signaling 0.002912493 3.5 NaN THBS1;THBS2
delavirdine Antiviral No MSN08 Down Thrombospondin receptor signaling 0.003705518 2 NaN THBS1;THBS2
delavirdine Antiviral No MSN01 Down Tropoelastin synthesis 0.02664079 8.5 NaN ELN
delavirdine Antiviral No MSN02 Down Tropoelastin synthesis 0.022406493 12.5 NaN ELN
delavirdine Antiviral No MSN05 Down Tropoelastin synthesis 0.023553282 15.5 NaN ELN
delavirdine Antiviral No MSN08 Down Tropoelastin synthesis 0.025317572 8 NaN ELN
delavirdine Antiviral No MSN09 Down Tropoelastin synthesis 0.027434721 11 NaN ELN
delavirdine Antiviral No MSN01 Down Vascular endothelial growth factor receptor signaling 0.013596343 5.5 NaN FLT1;KDR
delavirdine Antiviral No MSN08 Down Vascular endothelial growth factor receptor signaling 0.012331868 5 NaN FLT1;KDR
delavirdine Antiviral No MSN05 Down Vasoactive intestinal peptide receptor signaling 0.046553835 24 NaN VIPR1
delavirdine Antiviral No MSN05 Down Versican receptor signaling 0.046553835 24 NaN VCAN
delavirdine Antiviral No MSN08 Down Versican receptor signaling 0.049996342 12.5 NaN VCAN
delavirdine Antiviral No MSN05 Down Versican synthesis 0.023553282 15.5 NaN VCAN
delavirdine Antiviral No MSN08 Down Versican synthesis 0.025317572 8 NaN VCAN
delavirdine Antiviral No MSN01 Up WNT-Beta-catenin signaling pathway 0.000193151 1 NaN DKK1;DKK2;FRZB;FZD8;LEF1;SFRP2;WNT2
delavirdine Antiviral No MSN05 Up WNT-Beta-catenin signaling pathway 0.041836543 23 NaN FRZB;FZD8;SFRP2;WNT2
delavirdine Antiviral No MSN06 Up WNT-Beta-catenin signaling pathway 0.028856634 11 NaN DKK2;FZD8;LEF1;WNT9A
delavirdine Antiviral No MSN08 Up WNT-Beta-catenin signaling pathway 0.042952383 23 NaN FRZB;FZD7;FZD8;SFRP2
delavirdine Antiviral No MSN06 Down WNT-Beta-catenin signaling pathway 0.006657852 5 NaN DACT1;FRZB;PAX6;SFRP2;WNT3A;WNT5A
delavirdine Antiviral No MSN01 Up Z-disc organization 0.035773535 16 NaN MYPN;TCAP
delavirdine Antiviral No MSN02 Up Z-disc organization 0.048125749 24 NaN CSRP3;PDLIM3
delavirdine Antiviral No MSN06 Up Z-disc organization 0.033360102 12 NaN DES;TCAP
delavirdine Antiviral No MSN09 Up Z-disc organization 0.02930283 15 NaN DYSF;PDLIM3
delavirdine Antiviral No MSN06 Down Actin filament bundling and crosslinking 0.030172379 18 NaN FSCN2;TAGLN;USH1C
delavirdine Antiviral No MSN05 Down Actin polymerization 0.016697884 11 NaN ABRA;ACTA1;ENAH;VAV3
delavirdine Antiviral No MSN09 Down Actin polymerization 0.027447118 12 NaN ABRA;ACTA1;ENAH;INF2
delavirdine Antiviral No MSN09 Down Adherens junction organization 0.025363758 8 NaN ALCAM;CDH1;L1CAM;TIAM1
delavirdine Antiviral No MSN06 Up Aggrecan synthesis 0.018172195 9 NaN ACAN
delavirdine Antiviral No MSN09 Up Aggrecan synthesis 0.016937191 13 NaN ACAN
delavirdine Antiviral No MSN06 Up Albumin mediated blood protein transport 0.018172195 9 NaN ALB
delavirdine Antiviral No MSN09 Up Albumin mediated blood protein transport 0.016937191 13 NaN ALB
delavirdine Antiviral No MSN01 Down Albumin mediated blood protein transport 0.02664079 8.5 NaN ALB
delavirdine Antiviral No MSN02 Down Albumin mediated blood protein transport 0.022406493 12.5 NaN ALB
delavirdine Antiviral No MSN05 Down Albumin mediated blood protein transport 0.023553282 15.5 NaN ALB
delavirdine Antiviral No MSN08 Down Albumin mediated blood protein transport 0.025317572 8 NaN ALB
delavirdine Antiviral No MSN01 Up Alternative complement pathway 0.003416552 5 NaN C1S;CFH
delavirdine Antiviral No MSN02 Up Alternative complement pathway 0.004708979 7.5 NaN C1S;CFH
delavirdine Antiviral No MSN05 Up Alternative complement pathway 0.004004069 3.5 NaN C1S;CFH
delavirdine Antiviral No MSN06 Up Alternative complement pathway 0.003169819 4 NaN C3;CFH
delavirdine Antiviral No MSN08 Up Alternative complement pathway 0.004072101 5 NaN C1S;CFH
delavirdine Antiviral No MSN09 Up Alternative complement pathway 0.0027595 6 NaN C1S;CFH
delavirdine Antiviral No MSN09 Up Amyloid plaque organization 0.01419473 10.5 NaN HSPB6;VSNL1
delavirdine Antiviral No MSN02 Up Aspartate and arginine metabolism 0.019690847 16 NaN ARG2;DDAH1
delavirdine Antiviral No MSN05