predicTOX
Arrhythmia Hypertrophy Models
Arrhythmia Models
We provide an ODE computational model of how changes in gene expression can affect cardiomyocyte firing patterns. The MATLAB code is available for users to download. There is a ReadMe file for the model. The model enables simulations that test hypotheses regarding drug action and changes in gene expression can modulate cardiac action potential and firing patterns under varying conditions to predict drug action and adverse events. Details of model have been published in Shim et al.
Shim JV, Xiong Y, Dhanan P, Dariolli R, Azeloglu EU, Hu B, Jayaraman G, Schaniel C, Birtwistle MR, Iyengar R, Dubois NC, Sobie EA Predicting individual-specific cardiotoxicity responses induced by tyrosine kinase inhibitors. Front Pharmacol. 2023 Apr 10;14:1158222. doi: 10.3389/fphar.2023.1158222. eCollection 2023. PMID: 37101545
Hypertrophy Models
We provide an ODE computational model of how changes in gene expression can affect cardiomyocyte hypertrophy. The MATLAB code is available for users to download. There is a ReadMe file for the model. The model enables simulations that test hypotheses regarding drug action and changes in gene expression can modulate hypertrophy and predict adverse events. This model is based on a model originally published by Ryall et al.
Ryall KA, Holland DO, Delaney KA, Kraeutler MJ, Parker AJ, Saucerman JJ. (2012) Network reconstruction and systems analysis of cardiac myocyte hypertrophy signaling. J Biol Chem. 2012 Dec 7;287(50):42259-68. doi: 10.1074/jbc.M112.382937. Epub 2012 Oct 22. PMID: 23091058
