predicTOX

Summary Signatures

NaN = Not a Number/Not Determined

Summary Signatures: Induced pathways associated with cardiotoxicity

Cardiotoxic Pathway (Subcellular process) Up/Down Pathway F1 score AUC rank
Water transmembrane transport Down 9
Vascular endothelial growth factor receptor signaling Up 12
Transamination pathways Up 25
Thyroid hormone receptor signaling Up 10
Thin myofilament organization Down 21
Serine and glycine metabolism Up 19
Restriction point Up 3
Potassium transmembrane transport Up 7
Polyol pathway Down 4
Platelet-derived growth factor receptor signaling Down 14
Myofibril formation Down 6
Lysosomal glycoprotein degradation Up 2
Leptin receptor signaling Up 5
Hippo signaling Down 13
HIF-1 receptor signaling pathway Down 20
Granulocyte-colony stimulating factor receptor signaling Up 16
Gap junction organization Down 24
Desaturation of fatty acids Up 11
Citric acid cycle Up 1
Cholesterol-sensitive control of SREBP activation Up 15
Cholesterol synthesis Up 22
Chloride transmembrane transport Down 17
Cellular cholesterol uptake and efflux Down 23
Biglycan synthesis Down 18
Adrenergic receptor signaling Down 8

Summary Signatures: Genes of induced pathways associated with cardiotoxicity

Cardiotoxic Pathway (Subcellular process) Up/Down Gene Pathway F1 score AUC rank
Adrenergic receptor signaling Down ZDHHC7 8
Hippo signaling Down YAP1 13
Myofibril formation Down XIRP1 6
Hippo signaling Down WWTR1 13
Hippo signaling Down WWC1 13
Cellular cholesterol uptake and efflux Down VLDLR 23
HIF-1 receptor signaling pathway Down VHL 20
Thyroid hormone receptor signaling Up TRIP6 10
Lysosomal glycoprotein degradation Up TPP1 2
Thin myofilament organization Down TPM4 21
Thin myofilament organization Down TPM2 21
Thin myofilament organization Down TPM1 21
Thin myofilament organization Down TNNI3 21
Myofibril formation Down TMOD4 6
Myofibril formation Down TMOD1 6
Thyroid hormone receptor signaling Up THRB 10
Thyroid hormone receptor signaling Up THRA 10
Hippo signaling Down TEAD4 13
Hippo signaling Down TEAD2 13
Hippo signaling Down TEAD1 13
Leptin receptor signaling Up STAT3 5
Serine and glycine metabolism Up SRR 19
Cholesterol-sensitive control of SREBP activation Up SREBF2 15
Cholesterol-sensitive control of SREBP activation Up SREBF1 15
Cholesterol synthesis Up SQLE 22
Polyol pathway Down SORD 4
Leptin receptor signaling Up SOCS3 5
Myofibril formation Down SMYD1 6
Serine and glycine metabolism Up SLC1A5 19
Serine and glycine metabolism Up SLC1A4 19
Serine and glycine metabolism Up SHMT2 19
Cholesterol synthesis Up SEC14L2 22
Serine and glycine metabolism Up SDS 19
Citric acid cycle Up SDHD 1
Citric acid cycle Up SDHC 1
Citric acid cycle Up SDHB 1
Citric acid cycle Up SDHA 1
Desaturation of fatty acids Up SCD5 11
Desaturation of fatty acids Up SCD 11
Cellular cholesterol uptake and efflux Down SCARB2 23
Cellular cholesterol uptake and efflux Down SCARB1 23
Cellular cholesterol uptake and efflux Down SCARA3 23
Cholesterol-sensitive control of SREBP activation Up SCAP 15
Cholesterol synthesis Up SC5D 22
Hippo signaling Down SAV1 13
Cellular cholesterol uptake and efflux Down SAA1 23
Adrenergic receptor signaling Down RGS4 8
Adrenergic receptor signaling Down RGS16 8
Adrenergic receptor signaling Down RGS14 8
Restriction point Up RB1 3
Hippo signaling Down RASSF1 13
Adrenergic receptor signaling Down RASD1 8
Adrenergic receptor signaling Down RAPGEF4 8
Adrenergic receptor signaling Down RAPGEF3 8
Hippo signaling Down PTPN14 13
Serine and glycine metabolism Up PSPH 19
Serine and glycine metabolism Up PSAT1 19
Gap junction organization Down PRKCG 24
Adrenergic receptor signaling Down PPP1R9B 8
Cellular cholesterol uptake and efflux Down PON1 23
Cholesterol synthesis Up PMVK 22
Serine and glycine metabolism Up PICK1 19
Serine and glycine metabolism Up PHGDH 19
Restriction point Up PFKFB3 3
Myofibril formation Down PDLIM5 6
Citric acid cycle Up PDHB 1
Citric acid cycle Up PDHA2 1
Citric acid cycle Up PDHA1 1
Adrenergic receptor signaling Down PDE4D 8
Hippo signaling Down PAX3 13
Gap junction organization Down PANX3 24
Gap junction organization Down PANX2 24
Gap junction organization Down PANX1 24
Citric acid cycle Up OGDH 1
Cholesterol synthesis Up NSDHL 22
Hippo signaling Down NF2 13
Lysosomal glycoprotein degradation Up NEU3 2
Lysosomal glycoprotein degradation Up NEU1 2
Thin myofilament organization Down NEBL 21
Thyroid hormone receptor signaling Up NCOR2 10
Myofibril formation Down MYOZ1 6
Myofibril formation Down MYOT 6
Myofibril formation Down MYOG 6
Cellular cholesterol uptake and efflux Down MYLIP 23
Cholesterol synthesis Up MVK 22
Cholesterol synthesis Up MVD 22
Cellular cholesterol uptake and efflux Down MSR1 23
Cholesterol synthesis Up MSMO1 22
Hippo signaling Down MOB1B 13
Hippo signaling Down MOB1A 13
Lysosomal glycoprotein degradation Up MFSD8 2
Cholesterol-sensitive control of SREBP activation Up MBTPS2 15
HIF-1 receptor signaling pathway Down MAPK3 20
Cholesterol synthesis Up LSS 22
Thin myofilament organization Down LMOD3 21
Hippo signaling Down LIMD1 13
Leptin receptor signaling Up LEPR 5
Leptin receptor signaling Up LEP 5
Hippo signaling Down LATS2 13
Hippo signaling Down LATS1 13
Myofibril formation Down KLHL41 6
Leptin receptor signaling Up KHDRBS1 5
Cholesterol-sensitive control of SREBP activation Up INSIG2 15
Cholesterol-sensitive control of SREBP activation Up INSIG1 15
Lysosomal glycoprotein degradation Up IFI30 2
Citric acid cycle Up IDH2 1
Cholesterol synthesis Up HMGCS1 22
Cholesterol synthesis Up HMGCR 22
HIF-1 receptor signaling pathway Down HIF1AN 20
HIF-1 receptor signaling pathway Down HIF1A 20
Adrenergic receptor signaling Down GRK5 8
Transamination pathways Up GPT 25
Adrenergic receptor signaling Down GPR3 8
Transamination pathways Up GOT2 25
Transamination pathways Up GOT1 25
Adrenergic receptor signaling Down GNB3 8
Serine and glycine metabolism Up GLDC 19
Gap junction organization Down GJD2 24
Gap junction organization Down GJC3 24
Gap junction organization Down GJC2 24
Gap junction organization Down GJC1 24
Gap junction organization Down GJB6 24
Gap junction organization Down GJB5 24
Gap junction organization Down GJB4 24
Gap junction organization Down GJB3 24
Gap junction organization Down GJB2 24
Gap junction organization Down GJB1 24
Gap junction organization Down GJA8 24
Gap junction organization Down GJA5 24
Gap junction organization Down GJA4 24
Gap junction organization Down GJA3 24
Gap junction organization Down GJA1 24
Citric acid cycle Up FH 1
Cholesterol synthesis Up FDPS 22
Cholesterol synthesis Up FDFT1 22
Hippo signaling Down FAT4 13
Desaturation of fatty acids Up FADS3 11
Desaturation of fatty acids Up FADS2 11
Desaturation of fatty acids Up FADS1 11
Adrenergic receptor signaling Down EZR 8
HIF-1 receptor signaling pathway Down EGLN3 20
HIF-1 receptor signaling pathway Down EGLN1 20
Cholesterol synthesis Up EBP 22
Restriction point Up E2F1 3
Hippo signaling Down DYRK1A 13
Adrenergic receptor signaling Down DLG1 8
Citric acid cycle Up DLD 1
Citric acid cycle Up DLAT 1
Cholesterol synthesis Up DHCR7 22
Cholesterol synthesis Up DHCR24 22
Myofibril formation Down DES 6
Serine and glycine metabolism Up DAO 19
Cholesterol synthesis Up CYP51A1 22
Cholesterol synthesis Up CYP46A1 22
Cholesterol synthesis Up CYP27A1 22
Desaturation of fatty acids Up CYB5R4 11
HIF-1 receptor signaling pathway Down CUL2 20
Lysosomal glycoprotein degradation Up CTSA 2
Citric acid cycle Up CS 1
Hippo signaling Down CRB3 13
Hippo signaling Down CRB2 13
HIF-1 receptor signaling pathway Down COMMD1 20
HIF-1 receptor signaling pathway Down CITED2 20
Restriction point Up CDKN2A 3
Restriction point Up CDKN1B 3
Restriction point Up CDKN1A 3
Restriction point Up CDK6 3
Restriction point Up CCND3 3
Restriction point Up CCND2 3
Restriction point Up CCND1 3
Transamination pathways Up CCBL2 25
Transamination pathways Up CCBL1 25
Biglycan synthesis Down BGN 18
Transamination pathways Up BCAT2 25
Transamination pathways Up BCAT1 25
Hippo signaling Down AXL 13
Adrenergic receptor signaling Down ARRB2 8
Adrenergic receptor signaling Down ARRB1 8
Cellular cholesterol uptake and efflux Down ARL4C 23
Hippo signaling Down ANKHD1 13
Serine and glycine metabolism Up AMT 19
Hippo signaling Down AMOTL2 13
Hippo signaling Down AMOTL1 13
Hippo signaling Down AMOT 13
Polyol pathway Down AKR1B10 4
Polyol pathway Down AKR1B1 4
Polyol pathway Down AKR1A1 4
Adrenergic receptor signaling Down AKAP5 8
Adrenergic receptor signaling Down AKAP12 8
Hippo signaling Down AJUBA 13
Transamination pathways Up AGXT 25
Lysosomal glycoprotein degradation Up AGA 2
Adrenergic receptor signaling Down ADRBK2 8
Adrenergic receptor signaling Down ADRBK1 8
Adrenergic receptor signaling Down ADRB3 8
Adrenergic receptor signaling Down ADRB2 8
Adrenergic receptor signaling Down ADRB1 8
Adrenergic receptor signaling Down ADRA2A 8
Adrenergic receptor signaling Down ADRA1D 8
Adrenergic receptor signaling Down ADRA1B 8
Adrenergic receptor signaling Down ADCY6 8
Adrenergic receptor signaling Down ADCY2 8
Thin myofilament organization Down ACTA1 21
Desaturation of fatty acids Up ACOX1 11
Citric acid cycle Up ACO2 1
Cellular cholesterol uptake and efflux Down ABCG4 23
Cellular cholesterol uptake and efflux Down ABCG1 23
Cellular cholesterol uptake and efflux Down ABCA7 23
Cellular cholesterol uptake and efflux Down ABCA5 23
Cellular cholesterol uptake and efflux Down ABCA12 23
Cellular cholesterol uptake and efflux Down ABCA1 23
Transamination pathways Up AADAT 25
Cholesterol synthesis Up 6-Mar 22
Chloride TM transport Down 17
GCSF receptor signaling Up 16
PDGF receptor signaling Down 14
Potassium TM transport Up 7
VEGF receptor signaling Up 12
Water TM transport Down 9